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Aliases for RXRA Gene

Aliases for RXRA Gene

  • Retinoid X Receptor Alpha 2 3 4 5
  • Nuclear Receptor Subfamily 2 Group B Member 1 2 3 4
  • NR2B1 3 4
  • Retinoid X Nuclear Receptor Alpha 3
  • Retinoic Acid Receptor RXR-Alpha 3
  • Retinoid X Receptor, Alpha 2

External Ids for RXRA Gene

Previous GeneCards Identifiers for RXRA Gene

  • GC09P128442
  • GC09P129062
  • GC09P130816
  • GC09P132732
  • GC09P132661
  • GC09P134519
  • GC09P136358
  • GC09P137208
  • GC09P106757

Summaries for RXRA Gene

Entrez Gene Summary for RXRA Gene

  • Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for RXRA Gene

RXRA (Retinoid X Receptor Alpha) is a Protein Coding gene. Among its related pathways are Transcription_Role of VDR in regulation of genes involved in osteoporosis and Glioma. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is RXRG.

UniProtKB/Swiss-Prot for RXRA Gene

  • Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5-AGGTCA-3 sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.

Tocris Summary for RXRA Gene

  • Retinoid X receptors (RXR) are members of the NR2B nuclear receptor family and are common binding partners to many other nuclear receptors, including PPARs, liver X receptors (LXRs) and vitamin D receptors (VDRs). There are three RXR subtypes; alpha, beta and gamma.

Gene Wiki entry for RXRA Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RXRA Gene

Genomics for RXRA Gene

Regulatory Elements for RXRA Gene

Enhancers for RXRA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G134353 1.9 FANTOM5 Ensembl ENCODE dbSUPER 21 +40.7 40700 7.7 PKNOX1 AGO1 ZFP64 SIN3A ARID4B ZBTB7B TCF12 GLIS2 GATA2 ZNF207 RXRA ENSG00000273249 MIR4669
GH09G134369 2.1 FANTOM5 Ensembl ENCODE dbSUPER 16.4 +61.6 61637 18.8 MLX AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 RXRA ENSG00000273249 WDR5 REXO4 MIR4669
GH09G134338 2 FANTOM5 Ensembl ENCODE dbSUPER 15 +24.7 24693 7.2 HDGF FOXA2 PKNOX1 CREB3L1 ARNT MLX AGO1 ARID4B SIN3A DMAP1 RXRA COL5A1-AS1 MIR4669
GH09G134323 1.8 FANTOM5 ENCODE dbSUPER 12.2 +10.3 10289 7.6 HDGF PKNOX1 FOXA2 MLX ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1 ENSG00000273249 RXRA MIR4669
GH09G134363 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +49.1 49141 5.4 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A YBX1 DMAP1 ZBTB7B YY1 LINC00094 RXRA WDR5 MIR4669
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RXRA on UCSC Golden Path with GeneCards custom track

Promoters for RXRA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000242736 37 2201 HDGF PKNOX1 FOXA2 MLX ARNT AGO1 ARID4B SIN3A DMAP1 ZBTB7B

Genomic Location for RXRA Gene

Chromosome:
9
Start:
134,317,098 bp from pter
End:
134,440,586 bp from pter
Size:
123,489 bases
Orientation:
Plus strand

Genomic View for RXRA Gene

Genes around RXRA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RXRA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RXRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RXRA Gene

Proteins for RXRA Gene

  • Protein details for RXRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19793-RXRA_HUMAN
    Recommended name:
    Retinoic acid receptor RXR-alpha
    Protein Accession:
    P19793
    Secondary Accessions:
    • B3KY83
    • Q2NL52
    • Q2V504

    Protein attributes for RXRA Gene

    Size:
    462 amino acids
    Molecular mass:
    50811 Da
    Quaternary structure:
    • Homodimer. Heterodimer with RARA; required for ligand-dependent retinoic acid receptor transcriptional activity. Heterodimer with PPARA (via the leucine-like zipper in the LBD); the interaction is required for PPARA transcriptional activity. Also heterodimerizes with PPARG. Interacts with NCOA3 and NCOA6 coactivators. Interacts with FAM120B (By similarity). Interacts with PELP1, SENP6, SFPQ, DNTTIP2 and RNF8. Interacts (via the DNA binding domain) with HCV core protein; the interaction enhances the transcriptional activities of the RXRA/RARA and the RXRA/PPARA heterodimers. Interacts with PRMT2. Interacts with ASXL1 (By similarity). Interacts with BHLHE40/DEC1, BHLHE41/DEC2, NCOR1 and NCOR2. Interacts in a ligand-dependent fashion with MED1 and NCOA1.

    Three dimensional structures from OCA and Proteopedia for RXRA Gene

    Alternative splice isoforms for RXRA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RXRA Gene

Post-translational modifications for RXRA Gene

  • Phosphorylated on serine and threonine residues mainly in the N-terminal modulating domain. Constiutively phosphorylated on Ser-21 in the presence or absence of ligand. Under stress conditions, hyperphosphorylated by activated JNK on Ser-56, Ser-70, Thr-82 and Ser-260 (By similarity). Phosphorylated on Ser-27, in vitro, by PKA. This phosphorylation is required for repression of cAMP-mediated transcriptional activity of RARA.
  • Sumoylation negatively regulates transcriptional activity. Desumoylated specifically by SENP6.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RXRA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for RXRA (RXR alpha/NR2B1)
  • Cell Signaling Technology (CST) Antibodies for RXRA (RXRA)

No data available for DME Specific Peptides for RXRA Gene

Domains & Families for RXRA Gene

Gene Families for RXRA Gene

Graphical View of Domain Structure for InterPro Entry

P19793

UniProtKB/Swiss-Prot:

RXRA_HUMAN :
  • Composed of three domains: a modulating N-terminal domain (AF1 domain), a DNA-binding domain and a C-terminal ligand-binding domain (AF2 domain).
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
Domain:
  • Composed of three domains: a modulating N-terminal domain (AF1 domain), a DNA-binding domain and a C-terminal ligand-binding domain (AF2 domain).
Family:
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
genes like me logo Genes that share domains with RXRA: view

Function for RXRA Gene

Molecular function for RXRA Gene

GENATLAS Biochemistry:
retinoic acid X receptor binding and activated by 9-cis-retinoic acid,only (9-cis-RA),alpha subunit,regulating cardiac morphogenesis,obligate member of heterodimeric nuclear receptors,steroid/thyroid/retinoic receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5-AGGTCA-3 sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.

Gene Ontology (GO) - Molecular Function for RXRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 7831303
GO:0001972 retinoic acid binding IDA 19043829
GO:0003677 DNA binding TAS,IDA 12037571
GO:0003690 double-stranded DNA binding IMP 19043829
GO:0003700 contributes_to transcription factor activity, sequence-specific DNA binding IDA 17426122
genes like me logo Genes that share ontologies with RXRA: view
genes like me logo Genes that share phenotypes with RXRA: view

Animal Models for RXRA Gene

MGI Knock Outs for RXRA:

Animal Model Products

  • Taconic Biosciences Mouse Models for RXRA

CRISPR Products

Targeted motifs for RXRA Gene
HOMER Transcription Factor Regulatory Elements motif RXRA
  • Consensus sequence: TAGGGCAAAGGTCA Submotif: DR1 Cell Type: 3T3L1 GEO ID: GSE13511

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RXRA

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for RXRA Gene

Localization for RXRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for RXRA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RXRA gene
Compartment Confidence
nucleus 5
peroxisome 3
golgi apparatus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RXRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 18511497
GO:0005634 nucleus IDA 7990953
GO:0005654 nucleoplasm TAS --
GO:0043234 protein complex IDA 19043829
GO:0043235 receptor complex IDA 17426122
genes like me logo Genes that share ontologies with RXRA: view

Pathways & Interactions for RXRA Gene

genes like me logo Genes that share pathways with RXRA: view

SIGNOR curated interactions for RXRA Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for RXRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 17426122
GO:0001701 in utero embryonic development IEA --
GO:0001890 placenta development IEA --
GO:0001893 maternal placenta development IEA --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with RXRA: view

Drugs & Compounds for RXRA Gene

(49) Drugs for RXRA Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bexarotene Approved, Investigational Pharma Agonist, agonist, Target Others, Potent and selective RXR agonist 43
Adapalene Approved Pharma binder, Target, other/unknown RAR尾 and RAR纬 agonist 77
Acitretin Approved Pharma Target, agonist Metabolite of etretinate 30
Alitretinoin Approved, Investigational Pharma agonist, Target 17
Etodolac Approved, Investigational, Vet_approved Pharma Target, other COX-2 inhibitor 22

(16) Additional Compounds for RXRA Gene - From: Novoseek, HMDB, and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
9-cis-retinoic acid
  • 15-Apo-beta-caroten-15-oate
  • 15-Apo-beta-caroten-15-oic acid
  • 9-cis-Retinoate
  • 9-cis-Retinoic acid
  • 9-cis-Tretinoin
Agonist
SR11237
Agonist
all-trans-retinoic acid
  • (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate
  • (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
  • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate
  • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
  • Acide retinoique (French)
Full agonist, Agonist 302-79-4

(5) Tocris Compounds for RXRA Gene

Compound Action Cas Number
Bexarotene Potent and selective RXR agonist 153559-49-0
CD 3254 Potent and selective RXRalpha agonist. 196961-43-0
HX 531 Potent RXR antagonist 188844-34-0
SR 11237 Pan RXR agonist 146670-40-8
UVI 3003 RXR antagonist 847239-17-2

(12) ApexBio Compounds for RXRA Gene

Compound Action Cas Number
Acitretin Metabolite of etretinate 55079-83-9
Adapalene RAR尾 and RAR纬 agonist 106685-40-9
Bexarotene 153559-49-0
CD 3254 RXRα agonist,potent and selective 196961-43-0
Fluorobexarotene 1190848-23-7
HX 531 188844-34-0
HX 630 188844-52-2
LG 100754 180713-37-5
LG 101506 331248-11-4
PA 452 457657-34-0
SR 11237 146670-40-8
UVI 3003 847239-17-2
genes like me logo Genes that share compounds with RXRA: view

Transcripts for RXRA Gene

Unigene Clusters for RXRA Gene

Retinoid X receptor, alpha:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RXRA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RXRA Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2: - - - - - -
SP3:

Relevant External Links for RXRA Gene

GeneLoc Exon Structure for
RXRA
ECgene alternative splicing isoforms for
RXRA

Expression for RXRA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RXRA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RXRA Gene

This gene is overexpressed in Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for RXRA Gene

This gene is overexpressed in Liver (41.9) and Fetal gut (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RXRA Gene



NURSA nuclear receptor signaling pathways regulating expression of RXRA Gene:

RXRA

SOURCE GeneReport for Unigene cluster for RXRA Gene:

Hs.590886

mRNA Expression by UniProt/SwissProt for RXRA Gene:

P19793-RXRA_HUMAN
Tissue specificity: Highly expressed in liver, also found in lung, kidney and heart.

Evidence on tissue expression from TISSUES for RXRA Gene

  • Liver(4.7)
  • Nervous system(4.7)
  • Kidney(4.5)
  • Muscle(2.7)
  • Thyroid gland(2.7)
  • Skin(2.5)
  • Blood(2.4)
  • Lung(2.3)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with RXRA: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RXRA Gene

Orthologs for RXRA Gene

This gene was present in the common ancestor of animals.

Orthologs for RXRA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RXRA 34 35
  • 99.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RXRA 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RXRALPHA 35
  • 92 (a)
OneToOne
RXRA 34
  • 91.89 (n)
oppossum
(Monodelphis domestica)
Mammalia RXRA 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RXRA 34 35
  • 91.96 (n)
rat
(Rattus norvegicus)
Mammalia Rxra 34
  • 89.39 (n)
mouse
(Mus musculus)
Mammalia Rxra 34 16 35
  • 88.96 (n)
chicken
(Gallus gallus)
Aves RXRA 34 35
  • 86.08 (n)
lizard
(Anolis carolinensis)
Reptilia RXRA 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rxra 34
  • 79.81 (n)
Str.60 34
African clawed frog
(Xenopus laevis)
Amphibia rxra-A 34
zebrafish
(Danio rerio)
Actinopterygii rxrab 35
  • 89 (a)
OneToMany
rxraa 34 35
  • 77.11 (n)
rxrg 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9980 34
fruit fly
(Drosophila melanogaster)
Insecta usp 36 34 35
  • 62.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002095 34
  • 61.68 (n)
worm
(Caenorhabditis elegans)
Secernentea nhr-14 36
  • 31 (a)
nhr-17 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10537 35
  • 54 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.304 34
Species where no ortholog for RXRA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RXRA Gene

ENSEMBL:
Gene Tree for RXRA (if available)
TreeFam:
Gene Tree for RXRA (if available)

Paralogs for RXRA Gene

Variants for RXRA Gene

Sequence variations from dbSNP and Humsavar for RXRA Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000061318 -- 134,404,998(+) GGAGT(C/T)CTGAG intron-variant, upstream-variant-2KB
rs1000065519 -- 134,440,794(+) CCTCT(C/T)AGCAG downstream-variant-500B
rs1000101731 -- 134,380,565(+) GGTGT(C/T)CAGGG intron-variant
rs1000103777 -- 134,439,308(+) GGCAC(C/T)TTCAG utr-variant-3-prime
rs1000109480 -- 134,415,532(+) CAGGT(A/G)TTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RXRA Gene

Variant ID Type Subtype PubMed ID
dgv12970n54 CNV loss 21841781
dgv12971n54 CNV loss 21841781
dgv12972n54 CNV gain+loss 21841781
dgv12973n54 CNV loss 21841781
dgv12974n54 CNV gain 21841781
dgv7722n100 CNV gain 25217958
dgv7723n100 CNV gain 25217958
esv1003062 CNV insertion 20482838
esv1103609 CNV insertion 17803354
esv2105964 CNV deletion 18987734
esv2561499 CNV insertion 19546169
esv2673192 CNV deletion 23128226
esv2739138 CNV deletion 23290073
esv2739209 CNV deletion 23290073
esv27796 CNV loss 19812545
esv3360601 CNV insertion 20981092
nsv1053733 CNV gain 25217958
nsv1075687 CNV deletion 25765185
nsv1111377 CNV tandem duplication 24896259
nsv1125319 OTHER inversion 24896259
nsv1126927 CNV deletion 24896259
nsv1133747 CNV deletion 24896259
nsv1142559 CNV tandem duplication 24896259
nsv428227 CNV gain 18775914
nsv466633 CNV loss 19166990
nsv466634 CNV loss 19166990
nsv466635 CNV loss 19166990
nsv466636 CNV loss 19166990
nsv469908 CNV loss 18288195
nsv472234 CNV novel sequence insertion 20440878
nsv473477 CNV novel sequence insertion 20440878
nsv473482 CNV novel sequence insertion 20440878
nsv473849 CNV novel sequence insertion 20440878
nsv473892 CNV novel sequence insertion 20440878
nsv473991 CNV novel sequence insertion 20440878
nsv474419 CNV novel sequence insertion 20440878
nsv475454 CNV novel sequence insertion 20440878
nsv477697 CNV novel sequence insertion 20440878
nsv479201 CNV novel sequence insertion 20440878
nsv479221 CNV novel sequence insertion 20440878
nsv479878 CNV novel sequence insertion 20440878
nsv511426 CNV gain 21212237
nsv512999 CNV insertion 21212237
nsv615804 CNV loss 21841781
nsv615805 CNV loss 21841781
nsv615823 CNV loss 21841781
nsv615824 CNV gain 21841781
nsv615825 CNV loss 21841781
nsv615826 CNV loss 21841781
nsv825150 CNV gain 20364138
nsv825151 CNV gain 20364138
nsv825152 CNV gain 20364138
nsv825153 CNV loss 20364138
nsv831750 CNV gain+loss 17160897
nsv831751 CNV loss 17160897
nsv831752 CNV loss 17160897
nsv951809 CNV deletion 24416366

Variation tolerance for RXRA Gene

Residual Variation Intolerance Score: 9.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RXRA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RXRA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RXRA Gene

Disorders for RXRA Gene

Relevant External Links for RXRA

Genetic Association Database (GAD)
RXRA
Human Genome Epidemiology (HuGE) Navigator
RXRA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RXRA

No disorders were found for RXRA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RXRA Gene

Publications for RXRA Gene

  1. Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. (PMID: 19255064) Ahn J. … Hayes R.B. (Carcinogenesis 2009) 3 22 46 64
  2. RXRA gene variations influence Alzheimer's disease risk and cholesterol metabolism. (PMID: 19374686) KAPlsch H. … Heun R. (J. Cell. Mol. Med. 2009) 3 22 46 64
  3. Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer risk. (PMID: 19753122) Karami S. … Moore L.E. (PLoS ONE 2009) 3 22 46 64
  4. 9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway. (PMID: 16574651) Singh R.R. … Kumar R. (J. Biol. Chem. 2006) 3 4 22 64
  5. Nuclear receptor that identifies a novel retinoic acid response pathway. (PMID: 2159111) Mangelsdorf D.J. … Evans R.M. (Nature 1990) 2 3 4 64

Products for RXRA Gene

Sources for RXRA Gene

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