RXRA Gene
protein-coding GIFtS : 70 GCID: GC09 P137208
retinoid X receptor, alpha
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Aliasesfor RXRA gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Retinoid X Receptor, Alpha 1 2 NR2B11 2 3 Nuclear Receptor Subfamily 2 Group B Member 12 3 Retinoic Acid Receptor RXR-Alpha2 Retinoid X Nuclear Receptor Alpha2 Retinoid X Receptor Alpha3
Export aliases for RXRA gene to outside databases Previous GC identifers: GC09P128442 GC09P129062 GC09P130816 GC09P132732 GC09P132661 GC09P134519 GC09P136358 GC09P106757
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Summariesfor RXRA gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for RXRA : Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: RXRA_HUMAN, P19793 Function : Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements inresponse to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes summary
for RXRA : Retinoid X receptors (RXR) are members of the NR2B family of nuclear receptors and are common bindingpartners to many other nuclear receptors, including PPARs, liver X receptors (LXRs) and vitamin D receptors(VDR). RXR heterodimers act as ligand-dependent transcriptional regulators and increase the DNA-bindingefficiency of its partner. Despite numerous studies, the physiological role of RXRs have yet to been fullyelucidated and, as they can also exist as homodimers, there is the possibility that an independent RXRsignaling pathway exists. There are three RXR subtypes; RXRalpha, RXRbeta and RXRgamma, each with two majorisoforms (1 and 2). RXRalpha is expressed in the liver, kidney, epidermis and intestine, RXRbeta is widelydistributed and RXRgamma is restricted to muscle, pituitary gland and certain parts of the brain. Gene Wiki entry for RXRA (Retinoid X receptor alpha)
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Genomic Viewsfor RXRA gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000009.11 NC_018920.1 NT_019501.13 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RXRA gene promoter:c-Fos AhR AP-1 p300 c-Jun Other transcription factors Search SABiosciences Chromatin IP Primers for RXRA Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.2 HGNC cytogenetic band: 9q34 RXRA Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 9 GeneLoc Exon Structure
GeneLoc location for GC09P137208: view genomic region
(about GC identifiers )
Start: 137,208,944 bp from pter End:
137,332,431 bp from pter
Size: 123,488 bases Orientation:
plus strand
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Proteinsfor RXRA gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RXRA_HUMAN, P19793 See
protein sequence )Recommended Name: Size : 462 amino acids; 50811 DaSubunit : Homodimer. Heterodimer with RARA; required for ligand-dependent retinoic acid receptor transcriptionalactivity. Heterodimer with PPARA (via the leucine-like zipper in the LBD); the interaction is required for PPARA transcriptional activity. Also heterodimerizes with PPARG. Interacts with NCOA3 and NCOA6 coactivators. Interacts with FAM120B (By similarity). Interacts with PELP1, SENP6, SFPQ, DNTTIP2 and RNF8. Interacts (via the DNA binding domain) with HCV core protein; the interaction enhances the transcriptional activities of the RXRA/RARA and the RXRA/PPARA heterodimers. Interacts with PRMT2. Interacts with ASXL1 and NCOA1 (By similarity)
Subcellular location : Nucleus6/44 PDB 3D structures from (see all 44 ):1BY4 (3D) 1DSZ (3D) 1FBY (3D) 1FM6 (3D) 1FM9 (3D) 1G1U (3D) Secondary accessions : Q2NL52 Q2V504Explore the universe of human proteins at neXtProt for RXRA: NX_P19793 Post-translational modifications:
Phosphorylated on serine and threonine residues mainly in the N-terminal modulating domain. Constiutively phosphorylated on Ser-21 in the presence or absence of ligand. Under stress conditions, hyperphosphorylated by activated JNK on Ser-56, Ser-70, Thr-82 and Ser-260 (By similarity). Phosphorylated on Ser-27, in vitro, by PKA. This phosphorylation is required for repression of cAMP-mediated transcriptional activity of RARA1
Sumoylation negatively regulates transcriptional activity. Desumoylated specifically by SENP61 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P19793 RXRA Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_002948.1 ENSEMBL proteins: ENSP00000419692 ENSP00000442123 Reactome Protein details: P19793 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing RXRA Antibody Products: Assay Products for RXRA:
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Protein
Domains /for RXRA gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/7 InterPro domains/families (see all 7 ):
Graphical View of Domain Structure for InterPro Entry P19793 ProtoNet protein and cluster: P19793
2 Blocks protein families : IPB000003 IPB001723 UniProtKB/Swiss-Prot: RXRA_HUMAN, P19793 Domain : Composed of three domains: a modulating N-terminal domain (AF1 domain), a DNA-binding domain and a C-terminalligand-binding domain (AF2 domain) Similarity : Belongs to the nuclear hormone receptor family. NR2 subfamilySimilarity : Contains 1 nuclear receptor DNA-binding domain
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Functionfor RXRA gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: RXRA_HUMAN, P19793 Function : Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements inresponse to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes
Genatlas biochemistry entry for RXRA retinoic acid X receptor binding and activated by 9-cis-retinoic acid,only (9-cis-RA),alpha subunit,regulating cardiac morphogenesis,obligate member of heterodimeric nuclear receptors,steroid/thyroid/retinoic receptor superfamily Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RXRA (NM_002957 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RXRA Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RXRA
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RXRA
Gene Ontology (GO): 5/19 molecular function terms (GO ID links to tree view) (see all 19 ): About this table
About GeneDecksing Animal Models: Rxra tm1.1Pcn Rxra tm1Ipc Rxra tm4.1Ipc Rxra tm1.1Krc Rxra tm3Ipc Rxra tm1Rev Rxra tm2Ipc 15/26 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Rxra) (see all 26 ):About GeneDecksing
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Pathways & Interactionsfor RXRA gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/30 super-pathways (see all 30 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Transcription_Sin3 and NuRD in transcription regulation 2 Transcription_Role of VDR in regulation of genes involved in osteoporosis 3 Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) 4 Nuclear Receptor transcription pathway 5 Generic Transcription Pathway
Pathway sources See GeneCards unified pathways Show all pathways 5 4 5 5/10 (see all 10 ) 5/9 (see all 9 )5/8 (Kegg details for RXRA) (see all 8 ):About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RXRA STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/268 Interacting proteins for RXRA (P19793 1 , 2 , 3 ENSP00000419692 4 via UniProtKB, MINT, STRING , and/or I2D (see all 268 )Interactant Interaction Details GeneCard External ID(s) NCOA1 Q15788 2 , 3 ENSP00000320940 4 MINT-7986700 MINT-7986678 MINT-7986848 MINT-7986760 MINT-5224970 MINT-7986720 MINT-7986865 MINT-7986787 MINT-7986736 MINT-7986639 MINT-7986822 I2D:
score=5 STRING: ENSP00000320940 RARA P10276 1 , 2 , 3 ENSP00000254066 4 EBI-78598,EBI-413374 MINT-24895 I2D:
score=7 STRING: ENSP00000254066 NR1H3 Q13133 2 , 3 MINT-7986720 MINT-7986700 MINT-7986678 MINT-7986736 MINT-7986787 MINT-7986760 MINT-7986639 I2D:
score=5 PNRC2 Q9NPJ4 2 , 3 ENSP00000334840 4 MINT-14590 I2D:
score=1 STRING: ENSP00000334840 SMAD2 Q15796 2 , 3 ENSP00000262160 4 MINT-61590 I2D:
score=3 STRING: ENSP00000262160
About this table Gene Ontology (GO): 5/41 biological process terms (GO ID links to tree view) (see all 41 ): About this table
About GeneDecksing
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Drugs & Compoundsfor RXRA gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Compounds for RXRA available from Tocris Bioscience About this table 2 HMDB Compounds for RXRA About this table 10/11 DrugBank Compounds for RXRA (see all 11 )About this table 10/34 Novoseek chemical compound relationships for RXRA gene (see all 34 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
retinoic acid
86.7
136
10346893 (3), 8264664 (2), 8584029 (2), 12006543 (2) (see all 83 )
acyclic retinoid
83.9
3
19520494 (1), 11779708 (1)
retinoid
83.1
18
12365798 (2), 15082790 (2), 9823320 (1), 11779708 (1) (see all 13 )
androstane
72.3
5
16099843 (1), 15610735 (1), 17276571 (1), 19480556 (1) (see all 5 )
vitamin d
67.6
39
10692108 (4), 17707062 (3), 20049159 (3), 8552086 (2) (see all 24 )
bexarotene
65.6
2
12006543 (2)
etya
61.2
1
10231366 (1)
clofibric acid
55.8
2
1324435 (1)
calcitriol
50.1
3
10585721 (1), 19255064 (1), 17707062 (1)
steroid
47.2
7
9111344 (1), 10551830 (1), 7567979 (1), 17224343 (1) (see all 7 )
RXRA
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Transcriptsfor RXRA gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RXRA gene: NM_002957.4 Unigene Cluster for RXRA:
Retinoid X receptor, alpha Hs.590886 [show with all ESTs ] Unigene Representative Sequence: AK131081 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000484822 (uc004cfa.1 ) ENST00000481739 (uc004cfd.1 ) ENST00000356384 (uc004cfb.2 uc004cfc.1 )ENST00000540193 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RXRA (NM_002957 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RXRA Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RXRA
Additional cDNA sequence: AB307705.1 AF052092.1 AK131081.1 AK131513.1 BC007925.1 BC009882.2 BC031356.1 BC063827.1 BC096246.2 BC110998.1 HQ692843.1 U66306.1 X52773.1
9 DOTS entries : DT.116413 DT.102827176
DT.100785446 DT.91709154 DT.100785440 DT.121164622 DT.75120807 DT.95338039 DT.121164592 24/320 AceView cDNA sequences (see all 320 ):
AA642263 AI435301 CB160847 AW137188 W86756 CF136885 F31386 CA393592 CD518702 BM562776 CB160375 AI056830 BQ948043 AI934852 BU192986 CA430473 BU738433 CA393601 AA682398 AI312941 BU626526 BM563384 BM701589 BM674588 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for RXRA About this scheme ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b SP1 : - SP2 : - - - - - - SP3 :
ECgene alternative splicing isoforms for RXRA
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Expression for RXRA gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RXRA expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TATGTGCTGT
About this image RXRA expression in embryonic tissues and stem cells About this table See RXRA Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RXRA SOURCE GeneReport for Unigene cluster: Hs.590886 UniProtKB/Swiss-Prot: RXRA_HUMAN, P19793 Tissue specificity : Highly expressed in liver, also found in lung, kidney and heartSABiosciences Expression via Pathway-Focused PCR Arrays including RXRA (see all 6 ): Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RXRA
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Orthologsfor RXRA gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for RXRA gene from 5/22 species (see all 22 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves RXRA1
retinoid X receptor, alpha
86.08(n) 96.32(a)
417143 XM_003642291.1 XP_003642339.1
lizard Reptilia RXRA6
--
92(a)
1 ↔ 1
LGg(296946-338860)
African clawed frog Amphibia rxra-A2
retinoid X receptor, alpha
83.66(n)
L11446.1
zebrafish Actinopterygii rxrg2
retinoid x receptor, gamma
79.65(n)
30389 NM_131153.1
fruit fly Insecta usp3
metamorphosis ecdysteroid hormone receptor
47(a)
2C7 --
ENSEMBL Gene Tree for RXRA (if available)TreeFam Gene Tree for RXRA (if available)
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Paralogsfor RXRA gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for RXRA gene ESRRA 2 RXRG 2 PGR 2 ESR2 2 ESRRB 2 HNF4G 2 NR2F6 2 NR2E1 2 ESRRG 2 NR3C2 2 NR2F1 2 NR3C1 2 NR2F2 2 AR 2 ESR1 2 NR2C1 2 HNF4A 2 NR2C2 2 RXRB 2 18/47 SIMAP similar genes for RXRA using alignment to 3 protein entries: RXRA_HUMAN (see all proteins )
(see all similar genes ):NR2B1 FLJ00318 NR2B3 RXRG RXRB NR2B2 DKFZp779O0162 NR3C2 RORA HNF4G VDR HNF4alpha NR2A2 NR2A3 PPARG ESR1 PPARA NR2F2 About GeneDecksing
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Genomic Variantsfor RXRA gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 9 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for RXRA (137208944 - 137332431 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 9 variations for RXRA 8 CNVs 30337 52739 4659 52740 30338 4660 52741 70818 1 Indel 100801
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor RXRA gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 180245
OMIM disorders : --20/68 (see all 68 ): About MalaCards x-linked adrenal hypoplasia congenita recessive dystrophic epidermolysis bullosa epidermolysis bullosa retinol binding protein adrenal hypoplasia adenomatous polyposis coli thyroiditis familial combined hyperlipidemia biliary tract cancer esophageal squamous cell carcinoma acute promyelocytic leukemia squamous cell carcinoma differentiating neuroblastoma pancreatic ductal adenocarcinoma coronary heart disease hyperlipidemia cutaneous t cell lymphoma renal cell carcinoma choriocarcinoma rubella 1 disease from the University of Copenhagen DISEASES database for RXRA :Type VI Ehlers-Danlos syndrome 10/17 Novoseek disease relationships for RXRA gene (see all 17 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma embryonal
33.2
2
9892176 (1), 7624356 (1)
choriocarcinoma
29.8
1
19133314 (1)
hepatocellular carcinoma
27.1
9
11826406 (1), 19520494 (1), 11606411 (1), 19068086 (1) (see all 5 )
cancer
23.2
4
15140235 (1), 17909831 (1), 20428830 (1), 16621885 (1)
colon cancer
3.54
2
14670614 (1), 18202021 (1)
necrosis
2.36
1
17224343 (1)
breast carcinoma
0
1
15082790 (1)
inflammation
0
1
19700678 (1), 20463294 (1)
breast cancer
0
5
15082790 (2), 12365798 (1), 15171703 (1)
gastric cancer
0
2
9342842 (1), 12970875 (1)
Genetic Association Database (GAD): RXRA Human Genome Epidemiology (HuGE) Navigator: RXRA (37 documents) Export disorders for RXRA gene to outside databases
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Publicationsfor RXRA gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RXRA gene, integrated from 9 sources (see all 577 ):(articles sorted by number of sources associating them with RXRA) Utopia : connect your pdf to the dynamic
Nuclear receptor that identifies a novel retinoic acid response pathway. (PubMed id 2159111) 1 , 2 , 3(1990) 9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway. (PubMed id 16574651) 1 , 2 , 9(2006) Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1. (PubMed id 16912044) 1 , 2 (2006) Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases. (PubMed id 15635645) 1 , 4(2005) ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor. (PubMed id 15047147) 1 , 2 (2004) The RING finger protein, RNF8, interacts with retinoid X receptor alpha and enhances its transcription-stimulating activity. (PubMed id 14981089) 1 , 2 (2004) Interaction of hepatitis C virus core protein with re tinoid X receptor alpha modulates its transcriptional activity. (PubMed id 11915042) 1 , 2 (2002) Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha. (PubMed id 12039952) 1 , 2 (2002) PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors. (PubMed id 11259580) 1 , 2 (2001) Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1. (PubMed id 10698945) 1 , 2 (2000)
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External Searches for RXRA gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RXRA gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing RXRA gene
(According to HUGE )
About This Section --
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Specialized Databases showing RXRA gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for RXRA Pharmacogenomics, SNPs, Pathways ATLAS Chromosomes in Cancer entry for RXRAGenetics and Cytogenetics in Oncology and Haematology NIEHS-SNPs http://egp.gs.washington.edu/data/rxra/ Wikipedia http://en.wikipedia.org/wiki/Retinoid_X_receptor
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About This Section Patent Information for RXRA gene: RXRA GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RXRA gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for RXRA OriGene shRNA RFP for RXRA OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for RXRA OriGene 3'-UTR Clone for RXRA OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for RXRA OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for RXRA OriGene Custom Protein Services for RXRA OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RXRA QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for RXRA
Tocris compounds for RXRA
Recombinant Protein for RXRA
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RXRA
ThermoFisher Antibodies for RXRA
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RXRA
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summary
for 
and Proteopedia 
for RXRA (
Kegg Pathways 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Microarrays
In-situ hybridization
