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RXRA Gene

protein-coding GIFtS: 72

GC09P136358

retinoid X receptor, alpha
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ00280 ^²
FLJ00318 ^²
FLJ16020 ^²
FLJ16733 ^²
MGC102720 ^²
NR2B1 ^¹, ², ³
OTTHUMP00000022510 ^²

Descriptions
Nuclear receptor subfamily 2 group B member 1 ^³
Retinoid X receptor alpha ^³
retinoid X receptor, alpha ^²

External Ids
HGNC: 10477¹
Entrez Gene: 6256²
UniProtKB: P19793³
Ensembl: ENSG00000186350⁷

Search outside databases for aliases for RXRA gene

Previous GC identifers: GC09P128442 GC09P129062 GC09P130816 GC09P132732 GC09P132661 GC09P134519

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for RXRA:

Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate

the biological effects of retinoids by their involvement in retinoic acid-mediated gene

activation. These receptors exert their action by binding, as homodimers or heterodimers, to

specific sequences in the promoters of target genes and regulating their transcription. The

protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily

of transcriptional regulators. [provided by RefSeq]

UniProtKB/Swiss-Prot: RXRA_HUMAN, P19793

Function: Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis

retinoic acid (9C-RA). ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2)

enhancer (By similarity)

Gene Wiki entry for RXRA (Retinoid_X_receptor_alpha)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RXRA gene

Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.2 HGNC cytogenetic band: 9q34

RXRA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P136358: (about GC identifiers)

Start:	136,358,137 bp from pter
End:	136,472,252 bp from pter
Size:	114,116 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000009.10 NT_019501.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RXRA_HUMAN, P19793 (See protein sequence)

Recommended Name: Retinoic acid receptor RXR-alpha

Size: 462 amino acids; 50811 Da

Subunit: Homodimer or forms a heterodimer with peroxisome proliferator activated receptor gamma

called adipocyte-specific transcription factor ARF6. Interacts with NCOA3 and NCOA6 coactivators,

leading to a strong increase of transcription of target genes. Interacts with FAM120B (By

similarity). Interacts with SFPQ. Interacts with HCV core protein. Interacts with PELP1. Interacts

with SENP6. Interacts with DNTTIP2. Interacts with RNF8

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1BY4 (3D)

1DSZ (3D)

1FBY (3D)

1FM6 (3D)

1FM9 (3D)

1G1U (3D)

1G5Y (3D)

1K74 (3D)

1LBD (3D)

1MV9 (3D)

1MVC (3D)

1MZN (3D)

1R0N (3D)

1RDT (3D)

1RXR (3D)

1XLS (3D)

1XV9 (3D)

1XVP (3D)

1YNW (3D)

2ACL (3D)

2NLL (3D)

2P1T (3D)

2P1U (3D)

2P1V (3D)

3DZU (3D)

3DZY (3D)

3E00 (3D)

3E94 (3D)

3FAL (3D)

3FC6 (3D)

Secondary accessions: Q2V504

Post-translational modifications:

Sumoylated on Lys-108; which negatively regulates transcriptional activity. Desumoylated

specifically by SENP6¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002948.1

ENSEMBL proteins:

ENSP00000348749

Human Recombinant Proteins

	Invitrogen human recombinant proteins for RXRA
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Retinoid X Receptor alpha)
	Human Recombinant Proteins from Abnova (RXRA)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	7990953

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Antibodies for RXRA:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of RXRA
	Sigma-Aldrich Antibodies for RXRA
	R&D Systems Antibodies for RXRA (RXR alpha/NR2B1)
	Antibodies from Abcam (Retinoid X Receptor alpha), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RXRA)
	Novus Biologicals Antibodies for RXRA

Assays for RXRA:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P19793

ProtoNet protein and cluster: P19793

2 Blocks protein families:

IPB000003 Retinoic acid receptor signature

IPB001723 Steroid hormone receptor signature

UniProtKB/Swiss-Prot: RXRA_HUMAN, P19793

Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a

C-terminal steroid-binding domain

Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamily

Similarity: Contains 1 nuclear receptor DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RXRA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RXRA)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002957

Applied Biosystems Silencer® siRNAs for RXRA

Sigma-Aldrich siRNA and siRNA Panels for RXRA

Sigma-Aldrich shRNA Panels and shRNA for RXRA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for RXRA
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002957
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002957
untagged cDNA clone in CMV expression vector: NM_002957

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002957

UniProtKB/Swiss-Prot: RXRA_HUMAN, P19793

Function: Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis

retinoic acid (9C-RA). ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2)

enhancer (By similarity)

Genatlas biochemistry entry for RXRA:

retinoic acid X receptor binding and activated by 9-cis-retinoic acid,only (9-cis-RA),alpha

subunit,regulating cardiac morphogenesis,obligate member of heterodimeric nuclear

receptors,steroid/thyroid/retinoic receptor superfamily

15/26 MGI mutant phenotypes (inferred from 11 alleles) (MGI details for Rxra) (see all 26 ):

	behavior/neurological	craniofacial	digestive/alimentary	embryogenesis
endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism
immune system	lethality-postnatal	lethality-prenatal/perinatal	limbs/digits/tail	liver/biliary system

5/10 Gene Ontology (GO) molecular function terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IDA	12037571
GO:0003706	ligand-regulated transcription factor activity	IDA	7990953
GO:0003707	steroid hormone receptor activity	IEA	--
GO:0003713	transcription coactivator activity	TAS	1651173
GO:0004886	retinoid-X receptor activity	TAS	1310260

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/16 Sigma-Aldrich "Your Favorite Gene" Pathways for RXRA (Your Favorite Gene powered by Ingenuity) (see all 16 )

RAR Activation
PPAR Signaling
VDR/RXR Activation
PXR/RXR Activation
Aryl Hydrocarbon Receptor Signaling

GeneDecks RXRA for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for RXRA

5/103 Interacting proteins for RXRA (ENSP00000348749³ P19793^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 103 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NCOA1	Q15788²	STRING (score=.999) MINT-5224970
PNRC2	Q9NPJ4²	STRING (score=.723) MINT-14590
RARA	P10276²	STRING (score=.999) MINT-24895
EDF1	O60869¹	EBI-78598, EBI-781301
PRMT2	P55345¹	EBI-78598, EBI-78458

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5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006766	vitamin metabolic process	TAS	1651173
GO:0008203	cholesterol metabolic process	TAS	18544046
GO:0032526	response to retinoic acid	IMP	17538076

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for RXRA

Sigma-Aldrich Small Molecules for RXRA:

Activator Antagonist Ligand

Compounds for RXRA available from Tocris Bioscience

Compound	Action	CAS number
Liarozole hydrochloride	Blocks retinoic acid metabolism	[145858-50-0]
Fenretinide	Synthetic retinoid. Potent anti-cancer agent	[65646-68-6]
Retinoic acid	Endogenous retinoic acid receptor agonist. Also modulates PPARdelta	[302-79-4]

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10/15 Novoseek chemical compound relationships for RXRA gene (see all 15 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
androstane	72.13	4	16099843 (1), 15610735 (1), 17276571 (1), 12573484 (1)
etya	62.10	1	10231366 (1)
steroid	47.35	7	9111344 (1), 10551830 (1), 7567979 (1), 17224343 (1) (see all 7)
fatty acid	28.60	2	16513421 (1), 16731579 (1)
acyl-coa	27.98	3	1324435 (1), 17355985 (1)
triiodothyronine	26.49	1	9529340 (1)
thymidine	25.89	2	8559662 (1), 15322177 (1)
sterol	10.41	1	18177744 (1)
calcium	3.82	1	10692108 (1)
estradiol	3.03	1	7624356 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RXRA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RXRA)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002957

Sigma-Aldrich siRNA and siRNA Panels for RXRA

Sigma-Aldrich shRNA Panels and shRNA for RXRA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002957

REFSEQ mRNAs for RXRA gene:

NM_002957.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002957

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002957
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002957
                                 untagged cDNA clone in CMV expression vector: NM_002957

Additional cDNA sequence:

AB307705.1 AF052092.1 AK131081.1 AK131513.1 BC007925.1 BC009882.2 BC031356.1 BC063827.1

BC096246.2 BC110998.1 CR593545.1 U66306.1 X52773.1

9 DOTS entries:

DT.116413 DT.102827176 DT.91709154 DT.100785446 DT.100785440 DT.75120807 DT.95338039 DT.121164592

DT.121164622

24/320 AceView cDNA sequences (see all 320 ):

CA393592 CB160847 W86756 CF136885 AW137188 BQ948043 CB160375 BM562776

AI435301 AI493733 AI056830 BM930927 BU626526 AI061249 BM674588 BM994884

AA682398 CA393601 AI312941 F31386 BU686739 BF872897 BM975617 BU738433

highest scoring ESTs for RXRA:

U66306 X52773 AA004312 AA156826 AA203686 AA236526 AA351572 AA464615 AA492475 AA514484

Unigene Cluster for RXRA:

Retinoid X receptor, alpha

Hs.590886 [show with all ESTs]

Unigene Representative Sequence: AK131081

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for RXRA

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7	^	8a	·	8b
SP1:													-
SP2:							-		-		-		-		-		-
SP3:

About this scheme

ECgene alternative splicing isoforms for RXRA

1 Ensembl transcript including schematic representation:

ENST00000356384

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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RXRA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RXRA

¹ / ² / ³

6 probe-sets matching RXRA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32800_at²^{, 3}	U95-A	1	1.00	1.00	0.91	1.31	U66306	1.00	1.00	1.00	1
405_at²^{, 3}	U95-A	2	1.00	0.88	0.98	0.70	X52773	1.00	1.00	1.00	1
202449_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002957	0.60	1.00	0.82	1
202426_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BE675800	0.80	1.00	0.91	1
202449_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202426_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks RXRA for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TATGTGCTGT

SOURCE GeneReport for Unigene cluster: Hs.590886
Expression variation in blood from EXPOLDB for RXRA
UniProtKB/Swiss-Prot: RXRA_HUMAN, P19793
Tissue specificity: Highly expressed in liver, also found in lung, kidney and heart

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RXRA gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RXRA¹	--	retinoid X receptor, alpha	92.07(n) 98.72(a)	491278 XM_548399.2 XP_548399.2
chimpanzee (Pan troglodytes)	RXRA¹	--	retinoid X receptor, alpha	99.41(n) 99.56(a)	464834 XM_520345.2 XP_520345.2
cow (Bos taurus)	RXRA¹	--	retinoid X receptor, alpha	92.57(n) 97.79(a)	507554 XM_881943.2 XP_887036.2
rat (Rattus norvegicus)	Rxra¹	--	retinoid X receptor alpha	89.39(n) 98.48(a)	25271 NM_012805.1 NP_036937.1
mouse (Mus musculus)	Rxra^{1, 5}	2 (17.00 cM)⁵	retinoid X receptor alpha^{1, 5}	88.96(n)¹ 98.48(a)¹	20181¹ NM_011305.3¹ NP_035435.1¹ AI647710⁵ AK020634⁵ (see all 17)

About this table Species with no ortholog for RXRA

ENSEMBL Gene Tree for RXRA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for RXRA gene

RXRG² RXRB²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/923 NCBI SNPs in RXRA are shown (see all 923 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 469)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1045570^1,2	A,C,F,H,O	136472132(+)	`TGGCCG/TCAGGT`	1	--	ut3¹ ese³		15	MN EA NA EU WA NS	2482
	rs9615^1,2	A,C,F,H	136471346(+)	`TCGTGG/CAGCTG`	1	--	ut3¹		13	MN NA EU EA WA NS	918
	rs3132291^1,2	A,C,F	136472739(-)	`GGCTCT/CGGGCA`	1	--	ng3¹		8	NA NS	316
	rs1805342^1,2	C,F,H	136468521(+)	`ACTAGC/TGTGAG`	1	--	ut3¹		10	NA EU EA WA NS	700
	rs1805345^1,2	C,F,H	136460871(+)	`GAACAG/TCGCCC`	1	S/I	mis¹ ese³		8	NA MN CSAM EA	660
	rs1805346^1,2	C,F,H	136468654(+)	`TTTCCG/ATTGCT`	1	--	ut3¹ ese³		5	NA EU EA WA	514
--	rs4842194^1,2	A,C,F	136470381(+)	`GCCTTT/CTGCAG`	1	--	ut3¹ ese³		6	MN NS	372
	rs4240711^1,2	A,C,F	136469127(+)	`CTGAGA/GCTTGT`	1	--	ut3¹ ese³		5	NS	190
--	rs9930^1,2	C,F	136470931(-)	`GGAAGT/GGGGGG`	1	--	ut3¹		6	MN NS	360
--	rs10119893^1,2	C,F	136470625(+)	`GTCCCG/AGGCAC`	1	--	ut3¹ ese³		5	NS	188

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HapMap Linkage Disequilibrium images for RXRA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 180245

10/15 Novoseek disease relationships for RXRA gene (see all 15 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma embryonal	35.00	2	9892176 (1), 7624356 (1)
hepatocellular carcinoma	24.56	8	11826406 (1), 11606411 (1), 19068086 (1), 18451248 (1)
choriocarcinoma	23.18	1	19133314 (1)
cancer	21.99	3	15140235 (1), 17909831 (1), 16621885 (1)
colon cancer	6.64	2	14670614 (1), 18202021 (1)
necrosis	2.55	1	17224343 (1)
osteosarcoma	1.94	1	7705332 (1)
breast cancer	1.06	5	15082790 (2), 12365798 (1), 15171703 (1)
carcinoma	0.00	2	15285879 (2)
tumors	0.00	7	17909831 (1), 17224343 (1), 11779708 (1), 15126328 (1) (see all 7)

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Genetic Association Database: RXRA
Human Genome Epidemiology Navigator: RXRA (11 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/397 PubMed articles for RXRA gene (see all 397 ):

Nuclear receptor that identifies a novel retinoic acid response pathway. (PubMed id 2159111)^{2, 3, 4} Mangelsdorf D.J.... Evans R.M. (1990)
9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway. (PubMed id 16574651)^{1, 3, 4} Singh R.R.... Kumar R. (2006)
Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1. (PubMed id 16912044)^{3, 4} Choi S.J.... Chung C.H. (2006)
Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases. (PubMed id 15635645)^{3, 6} Feng J....Sommer S.S. (2005)
The RING finger protein, RNF8, interacts with retinoid X receptor alpha and enhances its transcription-stimulating activity. (PubMed id 14981089)^{3, 4} Takano Y....Okano Y. (2004)
ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor. (PubMed id 15047147)^{3, 4} Bu H.... Zhu Y.J. (2004)
PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors. (PubMed id 11259580)^{3, 4} Mathur M.... Samuels H.H. (2001)
A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. (PubMed id 10567404)^{3, 4} Lee S.-K.... Lee J.W. (1999)
High-resolution solution structure of the retinoid X receptor DNA- binding domain. (PubMed id 9698548)^{3, 4} Holmbeck S.M....Wright P.E. (1998)
Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. (PubMed id 9267036)^{3, 4} Chen H.... Evans R.M. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6256	HGNC: 10477	AceView: RXRA	Ensembl:ENSG00000186350	euGenes: HUgn6256
ECgene: RXRA	H-InvDB: RXRA

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for RXRA	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/rxra/
Wikipedia	http://en.wikipedia.org/wiki/Retinoid_X_receptor

Licensable Technologies for RXRA
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for RXRA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RXRA-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RXRA		Antibodies for RXRA
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RXRA		Small molecules for RXRA
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (RXRA)
	Antibodies (RXRA)
	Chimera RNAi (RXRA)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Retinoid X Receptor alpha)
	Antibodies (Retinoid X Receptor alpha)

Search OriGene for RXRA

Tocris compounds for RXRA

	Drugs for RXRA
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for RXRA

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
RXRA Gene at Home site.
Version 2.41.1
server5.xennexinc.com

RXRA Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for RXRA

Summaries
for RXRA

Genomic Location
for RXRA

Proteins
for RXRA

Protein Domains/
Families
for RXRA

Gene Function
for RXRA

Pathways & Interactions
for RXRA

Drugs & Compounds
for RXRA

Transcripts
for RXRA

Expression
for RXRA

Orthologs
for RXRA

Paralogs
for RXRA

SNPs/Variants
for RXRA

Disorders & Mutations
for RXRA

Medical News
for RXRA

Publications
for RXRA

Search for RXRA

Genome Databases showing RXRA

Other Databases showing RXRA

Specialized Databases showing RXRA

Licensable Technologies
for RXRA

Services
for RXRA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RXRA Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor RXRA

Summariesfor RXRA

Genomic Locationfor RXRA

Proteinsfor RXRA

Protein Domains/Familiesfor RXRA

Gene Functionfor RXRA

Pathways & Interactionsfor RXRA

Drugs & Compoundsfor RXRA

Transcriptsfor RXRA

Expression for RXRA

Orthologsfor RXRA

Paralogsfor RXRA

SNPs/Variantsfor RXRA

Disorders & Mutationsfor RXRA

Medical Newsfor RXRA

Publicationsfor RXRA

Search for RXRA

Genome Databases showing RXRA

Other Databases showing RXRA

Specialized Databases showing RXRA

Licensable Technologiesfor RXRA

Servicesfor RXRA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RXRA

Summaries
for RXRA

Genomic Location
for RXRA

Proteins
for RXRA

Protein Domains/
Families
for RXRA

Gene Function
for RXRA

Pathways & Interactions
for RXRA

Drugs & Compounds
for RXRA

Transcripts
for RXRA

Expression
for RXRA

Orthologs
for RXRA

Paralogs
for RXRA

SNPs/Variants
for RXRA

Disorders & Mutations
for RXRA

Medical News
for RXRA

Publications
for RXRA

Licensable Technologies
for RXRA

Services
for RXRA