Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RXFP4 Gene

Aliases for RXFP4 Gene

  • Relaxin/Insulin Like Family Peptide Receptor 4 2 3
  • Relaxin Family Peptide Receptor 4 2 3 4
  • Relaxin/Insulin-Like Family Peptide Receptor 4 3 5
  • Insulin-Like Peptide INSL5 Receptor 3 4
  • G-Protein Coupled Receptor GPCR142 3 4
  • G Protein-Coupled Receptor 100 2 3
  • G-Protein Coupled Receptor 100 3 4
  • Relaxin 3 Receptor 2 2 3
  • RLN3 Receptor 2 3 4
  • GPR100 3 4
  • RLN3R2 3 4
  • GPCR142 3
  • RXFPR4 3

External Ids for RXFP4 Gene

Previous HGNC Symbols for RXFP4 Gene

  • GPR100
  • RLN3R2

Previous GeneCards Identifiers for RXFP4 Gene

  • GC01P154178
  • GC01P127272

Summaries for RXFP4 Gene

Entrez Gene Summary for RXFP4 Gene

  • GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RXFP4 Gene

RXFP4 (Relaxin/Insulin Like Family Peptide Receptor 4) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and angiotensin type II receptor activity. An important paralog of this gene is ACKR3.

UniProtKB/Swiss-Prot for RXFP4 Gene

  • High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation.

Gene Wiki entry for RXFP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RXFP4 Gene

Genomics for RXFP4 Gene

Regulatory Elements for RXFP4 Gene

Enhancers for RXFP4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RXFP4 on UCSC Golden Path with GeneCards custom track

Promoters for RXFP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RXFP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for RXFP4 Gene

155,941,689 bp from pter
155,942,949 bp from pter
1,261 bases
Plus strand

Genomic View for RXFP4 Gene

Genes around RXFP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RXFP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RXFP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RXFP4 Gene

Proteins for RXFP4 Gene

  • Protein details for RXFP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Relaxin-3 receptor 2
    Protein Accession:
    Secondary Accessions:
    • B0M0L4
    • Q3MJB1
    • Q8NGZ8

    Protein attributes for RXFP4 Gene

    374 amino acids
    Molecular mass:
    41141 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05844.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for RXFP4 Gene

Proteomics data for RXFP4 Gene at MOPED

Post-translational modifications for RXFP4 Gene

  • Glycosylation at Asn 5 and Asn 17
  • Modification sites at PhosphoSitePlus

Other Protein References for RXFP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RXFP4 Gene

Domains & Families for RXFP4 Gene

Gene Families for RXFP4 Gene

Protein Domains for RXFP4 Gene

Suggested Antigen Peptide Sequences for RXFP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with RXFP4: view

Function for RXFP4 Gene

Molecular function for RXFP4 Gene

UniProtKB/Swiss-Prot Function:
High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation.
genes like me logo Genes that share phenotypes with RXFP4: view

Animal Models for RXFP4 Gene

MGI Knock Outs for RXFP4:

Animal Model Products

  • Taconic Biosciences Mouse Models for RXFP4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RXFP4 Gene

Localization for RXFP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RXFP4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for RXFP4 Gene COMPARTMENTS Subcellular localization image for RXFP4 gene
Compartment Confidence
plasma membrane 5
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for RXFP4 Gene

Pathways & Interactions for RXFP4 Gene

genes like me logo Genes that share pathways with RXFP4: view

Gene Ontology (GO) - Biological Process for RXFP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA --
GO:0007218 neuropeptide signaling pathway IBA --
genes like me logo Genes that share ontologies with RXFP4: view

No data available for SIGNOR curated interactions for RXFP4 Gene

Drugs & Compounds for RXFP4 Gene

(10) Drugs for RXFP4 Gene - From: DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
[<sup>125</sup>I]H3-B/INSL5 A chimera Pharma Agonist 0
[<sup>125</sup>I]INSL5 (human) Pharma Full agonist, Agonist 0
europium-labelled INSL5 Pharma 0
H3 relaxin Pharma Full agonist, Agonist 0

(3) Additional Compounds for RXFP4 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]H3 relaxin
Full agonist, Agonist
R3(BDelta23-27)R/I5 chimeric peptide
genes like me logo Genes that share compounds with RXFP4: view

Transcripts for RXFP4 Gene

mRNA/cDNA for RXFP4 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RXFP4 Gene

Relaxin/insulin-like family peptide receptor 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RXFP4 Gene

No ASD Table

Relevant External Links for RXFP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RXFP4 Gene

mRNA expression in normal human tissues for RXFP4 Gene

mRNA differential expression in normal tissues according to GTEx for RXFP4 Gene

This gene is overexpressed in Colon - Transverse (x21.9) and Small Intestine - Terminal Ileum (x6.0).

Protein differential expression in normal tissues from HIPED for RXFP4 Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RXFP4 Gene

SOURCE GeneReport for Unigene cluster for RXFP4 Gene Hs.449914

mRNA Expression by UniProt/SwissProt for RXFP4 Gene

Tissue specificity: Expressed in a broader range of tissues including brain, kidney, testis, thymus, placenta, prostate, salivary gland, thyroid and colon.
genes like me logo Genes that share expression patterns with RXFP4: view

Protein tissue co-expression partners for RXFP4 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RXFP4 Gene

Orthologs for RXFP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RXFP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RXFP4 35
  • 86.86 (n)
  • 85.79 (a)
RXFP4 36
  • 77 (a)
(Mus musculus)
Mammalia Rxfp4 35
  • 80.18 (n)
  • 76.76 (a)
Rxfp4 16
Rxfp4 36
  • 69 (a)
(Pan troglodytes)
Mammalia RXFP4 35
  • 99.64 (n)
  • 99.2 (a)
RXFP4 36
  • 99 (a)
(Monodelphis domestica)
Mammalia RXFP4 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486614 35
  • 56.08 (n)
  • 47.8 (a)
(Danio rerio)
Actinopterygii RXFP4 36
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8 36
  • 15 (a)
Species with no ortholog for RXFP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RXFP4 Gene

Gene Tree for RXFP4 (if available)
Gene Tree for RXFP4 (if available)

Paralogs for RXFP4 Gene

Paralogs for RXFP4 Gene

(5) SIMAP similar genes for RXFP4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RXFP4: view

Variants for RXFP4 Gene

Sequence variations from dbSNP and Humsavar for RXFP4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2152051 - 155,942,695(-) GCCTC(A/G)ACCGC reference, missense
rs1018730 -- 155,941,039(-) GAGAA(C/T)ACATG upstream-variant-2KB
rs6659649 -- 155,939,778(+) aaaaa(A/T)ttttt upstream-variant-2KB
rs6678443 -- 155,942,654(+) CGGGA(A/G)CCCCG reference, synonymous-codon
rs11300675 -- 155,939,778(+) AAAAA(-/T)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RXFP4 Gene

Variant ID Type Subtype PubMed ID
esv33869 CNV Loss 17666407
nsv509513 CNV Insertion 20534489

Variation tolerance for RXFP4 Gene

Residual Variation Intolerance Score: 73.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RXFP4 Gene

Disorders for RXFP4 Gene

Relevant External Links for RXFP4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RXFP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RXFP4 Gene

Publications for RXFP4 Gene

  1. INSL5 is a high affinity specific agonist for GPCR142 (GPR100). (PMID: 15525639) Liu C. … Lovenberg T.W. (J. Biol. Chem. 2005) 3 4 23 67
  2. Receptors for relaxin family peptides. (PMID: 15956688) Bathgate R.A. … Summers R.J. (Ann. N. Y. Acad. Sci. 2005) 2 3 23
  3. Identification of the domains in RXFP4 (GPCR142) responsible for the high affinity binding and agonistic activity of INSL5 at RXFP4 compared to RXFP3 (GPCR135). (PMID: 18582868) Zhu J. … Liu C. (Eur. J. Pharmacol. 2008) 3 23
  4. International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides. (PMID: 16507880) Bathgate R.A. … Summers R.J. (Pharmacol. Rev. 2006) 2 3
  5. Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7. (PMID: 15465925) Liu C. … Lovenberg T.W. (Mol. Pharmacol. 2005) 3 23

Products for RXFP4 Gene

Sources for RXFP4 Gene