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Aliases for RXFP4 Gene

Aliases for RXFP4 Gene

  • Relaxin/Insulin Like Family Peptide Receptor 4 2 3 5
  • Relaxin Family Peptide Receptor 4 2 3 4
  • Insulin-Like Peptide INSL5 Receptor 3 4
  • G-Protein Coupled Receptor GPCR142 3 4
  • G Protein-Coupled Receptor 100 2 3
  • RLN3 Receptor 2 3 4
  • GPR100 3 4
  • RLN3R2 3 4
  • G-Protein Coupled Receptor 100 4
  • Relaxin 3 Receptor 2 2
  • Relaxin-3 Receptor 2 3
  • GPCR142 3
  • RXFPR4 3

External Ids for RXFP4 Gene

Previous HGNC Symbols for RXFP4 Gene

  • GPR100
  • RLN3R2

Previous GeneCards Identifiers for RXFP4 Gene

  • GC01P154178
  • GC01P127272

Summaries for RXFP4 Gene

Entrez Gene Summary for RXFP4 Gene

  • GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RXFP4 Gene

RXFP4 (Relaxin/Insulin Like Family Peptide Receptor 4) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and angiotensin type II receptor activity. An important paralog of this gene is RXFP3.

UniProtKB/Swiss-Prot for RXFP4 Gene

  • High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation.

Gene Wiki entry for RXFP4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RXFP4 Gene

Genomics for RXFP4 Gene

Regulatory Elements for RXFP4 Gene

Enhancers for RXFP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G156099 2.5 VISTA FANTOM5 Ensembl ENCODE dbSUPER 10.5 +162.5 162477 8.4 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS LMNA MEX3A LAMTOR2 UBQLN4 BGLAP KIAA0907 RXFP4 FAM189B RIT1 YY1AP1
GH01G155965 1.8 FANTOM5 ENCODE dbSUPER 12.4 +33.7 33688 19.0 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 SLC30A9 ZNF416 ZNF143 ZNF263 RIT1 ARHGEF2 PAQR6 KIAA0907 ASH1L RXFP4 SCARNA4 LAMTOR2 UBQLN4 THBS3
GH01G156111 1.9 FANTOM5 ENCODE dbSUPER 10.4 +179.7 179701 19.4 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 KIAA0907 MSTO2P ENSG00000271267 RRNAD1 LMNA ASH1L BGLAP LOC246784 SYT11 MEX3A
GH01G156000 1.5 Ensembl ENCODE dbSUPER 12 +60.8 60790 3.6 HDGF FOXA2 CREB3L1 ARID4B SIN3A ZNF207 FOS ZNF263 JUNB SMARCB1 RIT1 RXFP4 KIAA0907 LAMTOR2 UBQLN4 SCARNA4 MEX3A LMNA SNORA80E GLMP
GH01G156281 1.8 FANTOM5 ENCODE dbSUPER 9.3 +341.6 341569 4.4 MLX CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 GLMP SMG5 SLC25A44 PAQR6 BGLAP ENSG00000252236 SEMA4A TSACC CCT3 KIAA0907
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RXFP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for RXFP4 Gene

Chromosome:
1
Start:
155,941,689 bp from pter
End:
155,942,949 bp from pter
Size:
1,261 bases
Orientation:
Plus strand

Genomic View for RXFP4 Gene

Genes around RXFP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RXFP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RXFP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RXFP4 Gene

Proteins for RXFP4 Gene

  • Protein details for RXFP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDU9-RL3R2_HUMAN
    Recommended name:
    Relaxin-3 receptor 2
    Protein Accession:
    Q8TDU9
    Secondary Accessions:
    • B0M0L4
    • Q3MJB1
    • Q8NGZ8

    Protein attributes for RXFP4 Gene

    Size:
    374 amino acids
    Molecular mass:
    41141 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05844.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for RXFP4 Gene

Post-translational modifications for RXFP4 Gene

  • Glycosylation at isoforms=5 and isoforms=17
  • Modification sites at PhosphoSitePlus

Other Protein References for RXFP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RXFP4 Gene

Domains & Families for RXFP4 Gene

Gene Families for RXFP4 Gene

Protein Domains for RXFP4 Gene

Suggested Antigen Peptide Sequences for RXFP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDU9

UniProtKB/Swiss-Prot:

RL3R2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with RXFP4: view

Function for RXFP4 Gene

Molecular function for RXFP4 Gene

UniProtKB/Swiss-Prot Function:
High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation.

Gene Ontology (GO) - Molecular Function for RXFP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004966 galanin receptor activity IBA --
GO:0005515 protein binding IPI 24802387
genes like me logo Genes that share ontologies with RXFP4: view
genes like me logo Genes that share phenotypes with RXFP4: view

Animal Models for RXFP4 Gene

MGI Knock Outs for RXFP4:

Animal Model Products

  • Taconic Biosciences Mouse Models for RXFP4

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RXFP4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RXFP4 Gene

Localization for RXFP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RXFP4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RXFP4 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for RXFP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RXFP4: view

Pathways & Interactions for RXFP4 Gene

genes like me logo Genes that share pathways with RXFP4: view

Gene Ontology (GO) - Biological Process for RXFP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA --
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with RXFP4: view

No data available for SIGNOR curated interactions for RXFP4 Gene

Drugs & Compounds for RXFP4 Gene

(10) Drugs for RXFP4 Gene - From: DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
[<sup>125</sup>I]H3-B/INSL5 A chimera Pharma Agonist 0
[<sup>125</sup>I]INSL5 (human) Pharma Full agonist, Agonist 0
europium-labelled INSL5 Pharma 0
H3 relaxin Pharma Full agonist, Agonist 0

(3) Additional Compounds for RXFP4 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]H3 relaxin
Full agonist, Agonist
R3(BDelta23-27)R/I5 chimeric peptide
Antagonist
genes like me logo Genes that share compounds with RXFP4: view

Transcripts for RXFP4 Gene

mRNA/cDNA for RXFP4 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RXFP4 Gene

Relaxin/insulin-like family peptide receptor 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RXFP4

Alternative Splicing Database (ASD) splice patterns (SP) for RXFP4 Gene

No ASD Table

Relevant External Links for RXFP4 Gene

GeneLoc Exon Structure for
RXFP4
ECgene alternative splicing isoforms for
RXFP4

Expression for RXFP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RXFP4 Gene

mRNA differential expression in normal tissues according to GTEx for RXFP4 Gene

This gene is overexpressed in Colon - Transverse (x21.9) and Small Intestine - Terminal Ileum (x6.0).

Protein differential expression in normal tissues from HIPED for RXFP4 Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RXFP4 Gene



Protein tissue co-expression partners for RXFP4 Gene

NURSA nuclear receptor signaling pathways regulating expression of RXFP4 Gene:

RXFP4

SOURCE GeneReport for Unigene cluster for RXFP4 Gene:

Hs.449914

mRNA Expression by UniProt/SwissProt for RXFP4 Gene:

Q8TDU9-RL3R2_HUMAN
Tissue specificity: Expressed in a broader range of tissues including brain, kidney, testis, thymus, placenta, prostate, salivary gland, thyroid and colon.

Evidence on tissue expression from TISSUES for RXFP4 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with RXFP4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for RXFP4 Gene

Orthologs for RXFP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RXFP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RXFP4 34 35
  • 99.64 (n)
cow
(Bos Taurus)
Mammalia RXFP4 34 35
  • 86.86 (n)
mouse
(Mus musculus)
Mammalia Rxfp4 34 16 35
  • 80.18 (n)
oppossum
(Monodelphis domestica)
Mammalia RXFP4 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486614 34
  • 56.08 (n)
zebrafish
(Danio rerio)
Actinopterygii RXFP4 35
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8 35
  • 15 (a)
OneToMany
Species where no ortholog for RXFP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RXFP4 Gene

ENSEMBL:
Gene Tree for RXFP4 (if available)
TreeFam:
Gene Tree for RXFP4 (if available)

Paralogs for RXFP4 Gene

Paralogs for RXFP4 Gene

(5) SIMAP similar genes for RXFP4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RXFP4: view

Variants for RXFP4 Gene

Sequence variations from dbSNP and Humsavar for RXFP4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000470577 -- 155,940,078(+) CAAGC(A/G)GTTAT upstream-variant-2KB
rs1001300618 -- 155,941,509(+) CACCA(A/G)TCTTG upstream-variant-2KB
rs1001755193 -- 155,941,447(+) ACAGG(C/T)GGGCG upstream-variant-2KB
rs1002102979 -- 155,940,894(+) CTCAA(G/T)GTCAC upstream-variant-2KB
rs1004078269 -- 155,943,130(+) AGTAT(A/G)GAACA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RXFP4 Gene

Variant ID Type Subtype PubMed ID
esv33869 CNV loss 17666407
nsv509513 CNV insertion 20534489

Variation tolerance for RXFP4 Gene

Residual Variation Intolerance Score: 73.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RXFP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RXFP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RXFP4 Gene

Disorders for RXFP4 Gene

Relevant External Links for RXFP4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RXFP4

No disorders were found for RXFP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RXFP4 Gene

Publications for RXFP4 Gene

  1. Receptors for relaxin family peptides. (PMID: 15956688) Bathgate R.A. … Summers R.J. (Ann. N. Y. Acad. Sci. 2005) 2 3 22 64
  2. INSL5 is a high affinity specific agonist for GPCR142 (GPR100). (PMID: 15525639) Liu C. … Lovenberg T.W. (J. Biol. Chem. 2005) 3 4 22 64
  3. Identification of relaxin-3/INSL7 as a ligand for GPCR142. (PMID: 14522967) Liu C. … Lovenberg T.W. (J. Biol. Chem. 2003) 3 4 22 64
  4. Identification and characterisation of GPR100 as a novel human G- protein-coupled bradykinin receptor. (PMID: 14530218) Boels K. … Schaller H.C. (Br. J. Pharmacol. 2003) 3 4 22 64
  5. Identification of the domains in RXFP4 (GPCR142) responsible for the high affinity binding and agonistic activity of INSL5 at RXFP4 compared to RXFP3 (GPCR135). (PMID: 18582868) Zhu J. … Liu C. (Eur. J. Pharmacol. 2008) 3 22 64

Products for RXFP4 Gene

  • Addgene plasmids for RXFP4

Sources for RXFP4 Gene

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