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RXFP4 Gene

protein-coding   GIFtS: 50
GCID: GC01P155911

Relaxin/Insulin-Like Family Peptide Receptor 4

(Previous names: G protein-coupled receptor 100, relaxin 3 receptor 2, relaxin...)
(Previous symbols: GPR100, RLN3R2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Relaxin/Insulin-Like Family Peptide Receptor 41 2     G-Protein Coupled Receptor 1002 3
Relaxin Family Peptide Receptor 41 2 3     G-Protein Coupled Receptor GPCR1422 3
GPR1001 2 3     RLN3 Receptor 22 3
RLN3R21 2 3     GPCR1422
G Protein-Coupled Receptor 1001 2     RXFPR42
Relaxin 3 Receptor 21 2     Relaxin-3 Receptor 22
Insulin-Like Peptide INSL5 Receptor2 3     

External Ids:    HGNC: 146661   Entrez Gene: 3394032   Ensembl: ENSG000001730807   OMIM: 6090435   UniProtKB: Q8TDU93   

Export aliases for RXFP4 gene to outside databases

Previous GC identifers: GC01P154178 GC01P127272


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RXFP4 Gene:
GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 (PubMed
14623098)).(supplied by OMIM, Mar 2008)

GeneCards Summary for RXFP4 Gene:
RXFP4 (relaxin/insulin-like family peptide receptor 4) is a protein-coding gene. Diseases associated with RXFP4 include cryptorchidism, and thyroiditis. GO annotations related to this gene include angiotensin type II receptor activity. An important paralog of this gene is RXFP3.

UniProtKB/Swiss-Prot: RL3R2_HUMAN, Q8TDU9
Function: High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and
kallidin. Binding of the ligand inhibit cAMP accumulation

Gene Wiki entry for RXFP4 (Relaxin/insulin-like family peptide receptor 4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RXFP4 gene promoter:
         NF-1/L   NF-1   AML1a   POU3F1   AP-4   C/EBPalpha   CREB   deltaCREB   c-Myb   ATF6   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for RXFP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RXFP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

RXFP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RXFP4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P155911:  view genomic region     (about GC identifiers)

Start:
155,911,480 bp from pter      End:
155,912,625 bp from pter
Size:
1,146 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RL3R2_HUMAN, Q8TDU9 (See protein sequence)
Recommended Name: Relaxin-3 receptor 2  
Size: 374 amino acids; 41141 Da
Sequence caution: Sequence=BAC05844.1; Type=Erroneous gene model prediction;
Secondary accessions: B0M0L4 Q3MJB1 Q8NGZ8

Explore the universe of human proteins at neXtProt for RXFP4: NX_Q8TDU9

Explore proteomics data for RXFP4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5, Asn17

  • See RXFP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_871001.1  
    ENSEMBL proteins: 
     ENSP00000357301  
    Reactome Protein details: Q8TDU9

    RXFP4 Human Recombinant Protein Products:

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    RXFP4 Antibody Products:

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    RXFP4 Assay Products:

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    Cloud-Clone Corp. CLIAs for RXFP4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RXFP: GPCR / Class A : Relaxin family peptide receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: RXFP4 receptor
    Relaxin family peptide receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn
     IPR000248 ATII_rcpt

    Graphical View of Domain Structure for InterPro Entry Q8TDU9

    ProtoNet protein and cluster: Q8TDU9

    UniProtKB/Swiss-Prot: RL3R2_HUMAN, Q8TDU9
    Similarity: Belongs to the G-protein coupled receptor 1 family


    RXFP4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RL3R2_HUMAN, Q8TDU9
    Function: High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and
    kallidin. Binding of the ligand inhibit cAMP accumulation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004945angiotensin type II receptor activity IEA--
         
    RXFP4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RXFP4:
     High actin ratio cells  Increased circadian period len 

         1 MGI phenotypic allele for Rxfp4 (no phenotypes)

    RXFP4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rxfp4tm1Lex for RXFP4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RXFP4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RXFP4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RXFP4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RXFP4

    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RXFP4

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RXFP4

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RXFP4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RL3R2_HUMAN, Q8TDU9: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    RXFP4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RXFP4 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    Relaxin receptors0.00
    Peptide ligand-binding receptors0.60
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for RXFP4
        Relaxin receptors
    G alpha (i) signalling events



    RXFP4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including RXFP4: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RXFP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RXFP4 (Q8TDU93 ENSP000003573014) via UniProtKB, MINT, STRING, and/or I2D (see all 145)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KNG1P010423, ENSP000002650234I2D: score=1 STRING: ENSP00000265023
    RLN3Q8WXF33I2D: score=2 
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY5ENSP000004193614STRING: ENSP00000419361
    ADCY9ENSP000002940164STRING: ENSP00000294016
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    RXFP4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RXFP4 (RL3R2)

    2 HMDB Compounds for RXFP4    About this table
    CompoundSynonyms CAS #PubMed Ids
    BradykininCallidin I (see all 5)58-82-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    7 IUPHAR Ligands for RXFP4 (RXFP4 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    [125I]H3 relaxin
    AgonistFull agonist8.7 - 9.714522967
    H3 relaxin
    AgonistFull agonist914522967
    [125I]H3-B/INSL5 A chimera
    AgonistAgonist8.915465925
    INSL5
    AgonistFull agonist8.815525639
    R3(BDelta23-27)R/I5 chimeric peptide
    AntagonistAntagonist8.6417606621
    [125I]INSL5 (human)
    AgonistFull agonist8.615525639
    europium-labelled INSL5
    NoneNone8.321384867

    2 Novoseek inferred chemical compound relationships for RXFP4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 23.4 2 14522967 (1), 17293890 (1)
    calcium 0 3 14522967 (1), 14530218 (1)



    RXFP4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RXFP4 gene: 
    NM_181885.2  

    Unigene Cluster for RXFP4:

    Relaxin/insulin-like family peptide receptor 4
    Hs.449914  [show with all ESTs]
    Unigene Representative Sequence: BC101509
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000368318(uc010pgs.2)
    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat RXFP4
      QuantiFast Probe-based Assays in human, mouse, rat RXFP4

    Additional mRNA sequence: 

    AY170824.1 AY288415.1 AY394502.1 BC101507.1 BC101509.1 EU432129.1 

    1 DOTS entry:

    DT.100693885 

    5 AceView cDNA sequences:

    AY170824 AY394502 NM_181885 AY288415 BU101743 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RXFP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RXFP4 Expression
    About this image

    RXFP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RXFP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.449914

    UniProtKB/Swiss-Prot: RL3R2_HUMAN, Q8TDU9
    Tissue specificity: Expressed in a broader range of tissues including brain, kidney, testis, thymus, placenta,
    prostate, salivary gland, thyroid and colon

        Pathway & Disease-focused RT2 Profiler PCR Array including RXFP4: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RXFP4 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rxfp41 , 5 relaxin family peptide receptor 41, 5 80.18(n)1
    76.76(a)1
      3 (38.92 cM)5
    2420931  NM_181817.11  NP_861538.11 
     886518985 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004866141 relaxin-3 receptor 2-like 56.08(n)
    47.8(a)
      100486614  XM_002945056.2  XP_002945102.2 
    zebrafish
    (Danio rerio)
    Actinopterygii RXFP46
    relaxin/insulin-like family peptide receptor 4
    43(a)
    1 → many
    7(35214671-35215725) ENSDARG00000069028


    ENSEMBL Gene Tree for RXFP4 (if available)
    TreeFam Gene Tree for RXFP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RXFP4 gene
    RXFP32  BDKRB12  AGTR22  GPR252  AGTR12  APLNR2  BDKRB22  ACKR32  
    GPR152  GPR1822  
    5 SIMAP similar genes for RXFP4 using alignment to 1 protein entry:     RL3R2_HUMAN:
    RXFP3    AGTR1    NPBWR1    NPBWR2    AGTR2

    RXFP4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RXFP4 (see all 112)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1995369361,2
    --155909560(+) AAAAG-/AAAAAA 1 -- us2k10--------
    rs66596491,2
    C--155909569(+) aaaaaA/Tttttt 1 -- us2k1 trp30--------
    rs113006751,2
    C,F--155909569(+) AAAAAT/-TTTTT 1 -- us2k13Minor allele frequency- -:0.50NA CSA 6
    rs1873633821,2
    --155909843(+) TACAGA/GCATGA 1 -- us2k10--------
    rs1494007711,2
    --155909904(+) ATTCTA/GGGTGG 1 -- us2k10--------
    rs610272341,2
    C,F--155910069(+) CAACAT/CGTTGG 1 -- us2k12Minor allele frequency- C:0.04WA 120
    rs1162179581,2
    F--155910411(+) GATGAG/TGTGTG 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1917825641,2
    C--155910473(+) AGTAGA/GGGGAC 1 -- us2k10--------
    rs1474986331,2
    C--155910479(+) GGGACC/TGCTGA 1 -- us2k10--------
    rs1115850291,2
    C,F--155910523(+) AAAGGC/TGGCGA 1 -- us2k12Minor allele frequency- T:0.04CSA WA 119

    HapMap Linkage Disequilibrium report for RXFP4 (155911480 - 155912625 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RXFP4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509513CNV Insertion20534489
    esv33869CNV Loss17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RXFP4
    DNA2.0 Custom Variant and Variant Library Synthesis for RXFP4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609043    OMIM disorders: --

    3 diseases for RXFP4:    
    About MalaCards
    cryptorchidism    thyroiditis    prostatitis


    RXFP4 for disorders           About GeneDecksing


    Export disorders for RXFP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RXFP4 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with RXFP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. INSL5 is a high affinity specific agonist for GPCR142 (GPR100). (PubMed id 15525639)1, 2, 9 Liu C.... Lovenberg T.W. (J. Biol. Chem. 2005)
    2. Identification of relaxin-3/INSL7 as a ligand for GPCR142. (PubMed id 14522967)1, 2, 9 Liu C....Lovenberg T.W. (J. Biol. Chem. 2003)
    3. Identification and characterisation of GPR100 as a novel human G- protein-coupled bradykinin receptor. (PubMed id 14530218)1, 2, 9 Boels K. and Schaller H.C. (Br. J. Pharmacol. 2003)
    4. Receptors for relaxin family peptides. (PubMed id 15956688)1, 3, 9 Bathgate R.A....Summers R.J. (Ann. N. Y. Acad. Sci. 2005)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides. (PubMed id 16507880)1, 3 Bathgate R.A....Summers R.J. (Pharmacol. Rev. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PubMed id 14623098)1, 2 Fredriksson R....Schioeth H.B. (FEBS Lett. 2003)
    9. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (FEBS Lett. 2002)
    10. Identification of the domains in RXFP4 (GPCR142) responsible for the high affinity binding and agonistic activity of INSL5 at RXFP4 compared to RXFP3 (GPCR135). (PubMed id 18582868)1, 9 Zhu J....Liu C. (Eur. J. Pharmacol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 339403 HGNC: 14666 AceView: GPR100 Ensembl:ENSG00000173080 euGenes: HUgn339403
    ECgene: RXFP4 H-InvDB: RXFP4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RXFP4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RXFP4 gene:
    Search GeneIP for patents involving RXFP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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