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Aliases for RXFP3 Gene

Aliases for RXFP3 Gene

  • Relaxin/Insulin-Like Family Peptide Receptor 3 2 3
  • Relaxin Family Peptide Receptor 3 2 3 4
  • RLN3R1 3 4 6
  • SALPR 3 4 6
  • Somatostatin- And Angiotensin-Like Peptide Receptor 3 4
  • G-Protein Coupled Receptor GPCR135 3 4
  • G Protein-Coupled Receptor SALPR 3 4
  • Relaxin 3 Receptor 1 2 3
  • RLN3 Receptor 1 3 4
  • GPCR135 3 6
  • Somatostatin And Angiotensin-Like Peptide Receptor 3
  • G-Protein Coupled Receptor SALPR 3
  • Relaxin-3 Receptor 1 3
  • RXFPR3 3

External Ids for RXFP3 Gene

Previous Symbols for RXFP3 Gene

  • RLN3R1

Summaries for RXFP3 Gene

GeneCards Summary for RXFP3 Gene

RXFP3 (Relaxin/Insulin-Like Family Peptide Receptor 3) is a Protein Coding gene. Diseases associated with RXFP3 include schizotypal personality disorder. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and N-formyl peptide receptor activity. An important paralog of this gene is ACKR3.

UniProtKB/Swiss-Prot for RXFP3 Gene

  • Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.

Gene Wiki entry for RXFP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RXFP3 Gene

Genomics for RXFP3 Gene

Genomic Location for RXFP3 Gene

Start:
33,936,386 bp from pter
End:
33,938,918 bp from pter
Size:
2,533 bases
Orientation:
Plus strand

Genomic View for RXFP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RXFP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RXFP3 Gene

Regulatory Elements for RXFP3 Gene

Proteins for RXFP3 Gene

  • Protein details for RXFP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSD7-RL3R1_HUMAN
    Recommended name:
    Relaxin-3 receptor 1
    Protein Accession:
    Q9NSD7
    Secondary Accessions:
    • Q14DA5

    Protein attributes for RXFP3 Gene

    Size:
    469 amino acids
    Molecular mass:
    51124 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RXFP3 Gene

Proteomics data for RXFP3 Gene at MOPED

Post-translational modifications for RXFP3 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn36 and Asn40

Other Protein References for RXFP3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RXFP3 Gene

Domains for RXFP3 Gene

Gene Families for RXFP3 Gene

HGNC:
  • RXFP :GPCR / Class A : Relaxin family peptide receptors
IUPHAR :

Protein Domains for RXFP3 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

RL3R1_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q9NSD7
genes like me logo Genes that share domains with RXFP3: view

Function for RXFP3 Gene

Molecular function for RXFP3 Gene

UniProtKB/Swiss-Prot Function: Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.

Gene Ontology (GO) - Molecular Function for RXFP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 10806363
GO:0008528 G-protein coupled peptide receptor activity IEA --
genes like me logo Genes that share ontologies with RXFP3: view

miRNA for RXFP3 Gene

miRTarBase miRNAs that target RXFP3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RXFP3 Gene

Localization for RXFP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RXFP3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RXFP3 Gene COMPARTMENTS Subcellular localization image for RXFP3 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for RXFP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10806363
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with RXFP3: view

Pathways for RXFP3 Gene

genes like me logo Genes that share pathways with RXFP3: view

Pathways by source for RXFP3 Gene

Interacting Proteins for RXFP3 Gene

Gene Ontology (GO) - Biological Process for RXFP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 10806363
GO:0032467 positive regulation of cytokinesis IMP 22888021
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA --
genes like me logo Genes that share ontologies with RXFP3: view

Compounds for RXFP3 Gene

(1) HMDB Compounds for RXFP3 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4

(8) IUPHAR Ligand for RXFP3 Gene

Ligand Type Action Affinity Pubmed IDs
[125I]H3 relaxin Agonist Full agonist 9.7
H3 relaxin/INSL5 chimera Agonist Full agonist 9.3
[125I]H3-B/INSL5 A chimera Agonist Agonist 8.9
INSL5 Agonist Full agonist 8.8
R3(BDelta23-27)R/I5 chimeric peptide Antagonist Antagonist 8.64
R3-B1-22R Antagonist Antagonist 7.4
H3 relaxin Agonist Full agonist 7
H3 relaxin (B chain) Agonist Full agonist 6.9

(1) Novoseek inferred chemical compound relationships for RXFP3 Gene

Compound -log(P) Hits PubMed IDs
adenylate 15.3 2
genes like me logo Genes that share compounds with RXFP3: view

Transcripts for RXFP3 Gene

mRNA/cDNA for RXFP3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RXFP3 Gene

Relaxin/insulin-like family peptide receptor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RXFP3 Gene

No ASD Table

Relevant External Links for RXFP3 Gene

GeneLoc Exon Structure for
RXFP3
ECgene alternative splicing isoforms for
RXFP3

Expression for RXFP3 Gene

mRNA expression in normal human tissues for RXFP3 Gene

mRNA differential expression in normal tissues according to GTEx for RXFP3 Gene

This gene is overexpressed in Adrenal Gland (19.3), Brain - Hypothalamus (7.0), and Pituitary (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RXFP3 Gene

SOURCE GeneReport for Unigene cluster for RXFP3 Gene Hs.170146

mRNA Expression by UniProt/SwissProt for RXFP3 Gene

Q9NSD7-RL3R1_HUMAN
Tissue specificity: Expressed predominantly in brain regions. Highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, quite low level in cerebellum. In peripheral tissues, relatively high levels in adrenal glands, low levels in pancreas, salivary gland, placenta, mammary gland and testis
genes like me logo Genes that share expressions with RXFP3: view

Orthologs for RXFP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RXFP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RXFP3 36
  • 99.22 (n)
  • 98.51 (a)
RXFP3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RXFP3 36
  • 89.81 (n)
  • 89.74 (a)
RXFP3 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RXFP3 36
  • 86.46 (n)
  • 82.31 (a)
RXFP3 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rxfp3 36
  • 84.86 (n)
  • 86.35 (a)
Rxfp3 16
Rxfp3 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RXFP3 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RXFP3 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rxfp3 36
  • 84.72 (n)
  • 85.93 (a)
chicken
(Gallus gallus)
Aves RXFP3 36
  • 74.64 (n)
  • 74.73 (a)
RXFP3 37
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rxfp3 36
  • 68.92 (n)
  • 74.23 (a)
zebrafish
(Danio rerio)
Actinopterygii rxfp3 36
  • 66.85 (n)
  • 71.03 (a)
rxfp3 37
  • 65 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8 37
  • 20 (a)
OneToMany
Species with no ortholog for RXFP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RXFP3 Gene

ENSEMBL:
Gene Tree for RXFP3 (if available)
TreeFam:
Gene Tree for RXFP3 (if available)

Paralogs for RXFP3 Gene

Paralogs for RXFP3 Gene

Selected SIMAP similar genes for RXFP3 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RXFP3 Gene

genes like me logo Genes that share paralogs with RXFP3: view

Variants for RXFP3 Gene

Sequence variations from dbSNP and Humsavar for RXFP3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs35416 -- 33,935,376(+) TTCCA(C/T)TGGTC upstream-variant-2KB
rs35417 -- 33,934,852(+) GAGAT(A/G)TTTGT upstream-variant-2KB
rs42868 -- 33,935,971(+) TGCAG(C/G)TGTAA upstream-variant-2KB
rs171631 -- 33,938,870(+) TAACA(A/C)CTGTC utr-variant-3-prime
rs3832336 -- 33,938,234(-) CCCCC(-/C)AGCCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RXFP3 Gene

Variant ID Type Subtype PubMed ID
nsv522715 CNV Gain 19592680
nsv462114 CNV Loss 19166990
nsv830255 CNV Loss 17160897
nsv462115 CNV Loss 19166990

Relevant External Links for RXFP3 Gene

HapMap Linkage Disequilibrium report
RXFP3

Disorders for RXFP3 Gene

genes like me logo Genes that share disorders with RXFP3: view

No data available for UniProtKB/Swiss-Prot for RXFP3 Gene

Publications for RXFP3 Gene

  1. The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors. (PMID: 10806363) Matsumoto M. … Furuichi K. (Gene 2000) 3 4 23
  2. Receptors for relaxin family peptides. (PMID: 15956688) Bathgate R.A. … Summers R.J. (Ann. N. Y. Acad. Sci. 2005) 2 3 23
  3. Responses of GPCR135 to human gene 3 (H3) relaxin in CHO-K1 cells determined by microphysiometry. (PMID: 15956730) Van der Westhuizen E.T. … Summers R.J. (Ann. N. Y. Acad. Sci. 2005) 3 23
  4. Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7. (PMID: 15465925) Liu C. … Lovenberg T.W. (Mol. Pharmacol. 2005) 3 23
  5. Identification of the domains in RXFP4 (GPCR142) responsible for the high affinity binding and agonistic activity of INSL5 at RXFP4 compared to RXFP3 (GPCR135). (PMID: 18582868) Zhu J. … Liu C. (Eur. J. Pharmacol. 2008) 3 23

Products for RXFP3 Gene

Sources for RXFP3 Gene

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