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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RXFP3 Gene

protein-coding   GIFtS: 54
GCID: GC05P033974

Relaxin/Insulin-Like Family Peptide Receptor 3

(Previous names: relaxin 3 receptor 1, relaxin family peptide receptor 3)
(Previous symbol: RLN3R1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Relaxin/Insulin-Like Family Peptide Receptor 31 2     G-Protein Coupled Receptor GPCR1352 3
RLN3R11 2 3 5     RLN3 Receptor 12 3
Relaxin Family Peptide Receptor 31 2 3     GPCR1352 5
SALPR2 3 5     RXFPR32
Relaxin 3 Receptor 11 2     G-Protein Coupled Receptor SALPR2
G Protein-Coupled Receptor SALPR2 3     Relaxin-3 Receptor 12
Somatostatin- And Angiotensin-Like Peptide Receptor2 3     Somatostatin And Angiotensin-Like Peptide Receptor2

External Ids:    HGNC: 248831   Entrez Gene: 512892   Ensembl: ENSG000001826317   OMIM: 6094455   UniProtKB: Q9NSD73   

Export aliases for RXFP3 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RXFP3 Gene: 
RXFP3 (relaxin/insulin-like family peptide receptor 3) is a protein-coding gene. Diseases associated with RXFP3 include schizotypal personality disorder, and personality disorder, and among its related super-pathways are GPCR ligand binding and Signaling by GPCR. GO annotations related to this gene include N-formyl peptide receptor activity and G-protein coupled receptor activity. An important paralog of this gene is BDKRB1.

UniProtKB/Swiss-Prot: RL3R1_HUMAN, Q9NSD7
Function: Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation

Gene Wiki entry for RXFP3 (Relaxin/insulin-like family peptide receptor 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RXFP3 gene promoter:
         AML1a   RREB-1   NRSF form 1   AP-4   STAT5A   NRSF form 2   Pax-3   c-Myb   ZIC2/Zic2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRXFP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for RXFP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RXFP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.1-p14   Ensembl cytogenetic band:  5p13.2   HGNC cytogenetic band: 5p15.1-p14

RXFP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RXFP3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P033974:  view genomic region     (about GC identifiers)

Start:
33,936,491 bp from pter      End:
33,939,023 bp from pter
Size:
2,533 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RL3R1_HUMAN, Q9NSD7 (See protein sequence)
Recommended Name: Relaxin-3 receptor 1  
Size: 469 amino acids; 51124 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q14DA5

Explore the universe of human proteins at neXtProt for RXFP3: NX_Q9NSD7

Explore proteomics data for RXFP3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NSD7

  • RXFP3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RXFP3 Protein Expression
    REFSEQ proteins: NP_057652.1  
    ENSEMBL proteins: 
     ENSP00000328708  
    Reactome Protein details: Q9NSD7
    Human Recombinant Protein Products for RXFP3: 
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    Novus Biologicals RXFP3 Proteins
    Novus Biologicals RXFP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RXFP3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS10806363
    GO:0016021integral to membrane ----

    RXFP3 for ontologies           About GeneDecksing



    RXFP3 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for RXFP3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RXFP: GPCR / Class A : Relaxin family peptide receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: RXFP3 receptor 
    Relaxin family peptide receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000826 Formyl_pep_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9NSD7

    ProtoNet protein and cluster: Q9NSD7

    UniProtKB/Swiss-Prot: RL3R1_HUMAN, Q9NSD7
    Similarity: Belongs to the G-protein coupled receptor 1 family


    RXFP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RL3R1_HUMAN, Q9NSD7
    Function: Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS10806363
    GO:0004982N-formyl peptide receptor activity IEA--
    GO:0008528G-protein coupled peptide receptor activity ----
         
    RXFP3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RXFP3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RXFP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RXFP3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RXFP3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RXFP3
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate RXFP3:
    hsa-miR-1224-3p hsa-miR-1260b hsa-miR-1260
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RXFP3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RXFP3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3Relaxin receptors
    Relaxin receptors
    4GPCRs, Other
    GPCRs, Other

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RXFP3
        GPCRs, Other


    5/8        Reactome Pathways for RXFP3 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events



    RXFP3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RXFP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/144 Interacting proteins for RXFP3 (ENSP000003287084) via UniProtKB, MINT, STRING, and/or I2D (see all 144)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY2ENSP000003429524STRING: ENSP00000342952
    DRD4ENSP000001761834STRING: ENSP00000176183
    GALENSP000002656434STRING: ENSP00000265643
    GPR55ENSP000003758934STRING: ENSP00000375893
    KNG1ENSP000002650234STRING: ENSP00000265023
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS10806363
    GO:0051482elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA--

    RXFP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RXFP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RXFP3 (RL3R1)

    1 HMDB Compound for RXFP3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    8 IUPHAR Ligands for RXFP3 (RXFP3 receptor)    About this table 
    LigandTypeActionAffinityPubmed IDs
    H3 relaxin
    AgonistFull agonist9.4 - 9.615367576 14522968
    [125I]H3 relaxin
    AgonistFull agonist9.514522968
    [125I]H3-B/INSL5 A chimera
    AgonistAgonist9.315465925
    H3 relaxin/INSL5 chimera
    AgonistFull agonist9.315465925
    R3(BΔ23-27)R/I5 chimeric peptide
    AntagonistAntagonist9.217606621
    R3-B1-22R
    AntagonistAntagonist7.421384867
    H3 relaxin (B chain)
    AgonistFull agonist6.914522968
    INSL5
    AntagonistAntagonist6.315525639

    1 Novoseek inferred chemical compound relationship for RXFP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 15.3 3 14522967 (1), 17293890 (1)

    Search CenterWatch for drugs/clinical trials and news about RXFP3 / RL3R1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RXFP3 gene: 
    NM_016568.3  

    Unigene Cluster for RXFP3:

    Relaxin/insulin-like family peptide receptor 3
    Hs.170146  [show with all ESTs]
    Unigene Representative Sequence: NM_016568
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000330120(uc003jic.2)
    miRNA
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    hsa-miR-1224-3p hsa-miR-1260b hsa-miR-1260
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RXFP3
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    Sirion Biotech Customized lentivirus for stable overexpression of RXFP3 
                         Customized lentivirus expression plasmids for stable overexpression of RXFP3 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RXFP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RXFP3

    Additional mRNA sequence: 

    AY394501.1 BC095526.1 BC113438.1 BC113440.1 D88437.1 

    1 DOTS entry:

    DT.40294969 

    6 AceView cDNA sequences:

    AY394501 D88437 CN839244 CN835032 CN835129 NM_016568 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RXFP3 expression in normal human tissues (normalized intensities)      RXFP3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCCCCTTCA
    RXFP3 Expression
    About this image


    RXFP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node

    See RXFP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RXFP3

    SOURCE GeneReport for Unigene cluster: Hs.170146

    UniProtKB/Swiss-Prot: RL3R1_HUMAN, Q9NSD7
    Tissue specificity: Expressed predominantly in brain regions. Highest expression in substantia nigra and
    pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, quite low level
    in cerebellum. In peripheral tissues, relatively high levels in adrenal glands, low levels in pancreas, salivary
    gland, placenta, mammary gland and testis

        SABiosciences Expression via Pathway-Focused PCR Array including RXFP3: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RXFP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RXFP3 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rxfp31 , 5 relaxin family peptide receptor 31, 5 84.86(n)1
    86.35(a)1
      15 (5.42 cM)5
    2393361  NM_178717.31  NP_848832.11 
     110337175 
    chicken
    (Gallus gallus)
    Aves RXFP31 relaxin/insulin-like family peptide receptor 3 72.39(n)
    71.64(a)
      431664  XM_429217.3  XP_429217.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rxfp31 relaxin/insulin-like family peptide receptor 3 67.04(n)
    72.07(a)
      794924  NM_001128788.2  NP_001122260.1 


    ENSEMBL Gene Tree for RXFP3 (if available)
    TreeFam Gene Tree for RXFP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RXFP3 gene
    BDKRB12  AGTR22  GPR252  AGTR12  APLNR2  BDKRB22  ACKR32  GPR152  
    RXFP42  GPR1822  
    5 SIMAP similar genes for RXFP3 using alignment to 2 protein entries:     RL3R1_HUMAN (see all proteins):
    CMKLR1    GPR18    RXFP4    AGTR1    SSTR2

    RXFP3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RXFP3
    PGOHUM00000247195


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/155 SNPs in RXFP3 are shown (see all 155)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs779026171,2
    C,F--33934549(+) ATCAGG/ACCCCT 1 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1831967351,2
    --33934565(+) TTTTTC/TATAAA 1 -- us2k10--------
    rs572466941,2
    C--33934693(+) AAATTT/GAACAG 1 -- us2k14Minor allele frequency- G:0.08WA NA EA 360
    rs1459996211,2
    --33934706(+) GAGAGC/TTTTCA 1 -- us2k10--------
    rs100457591,2
    C,F,H--33934758(+) AATATT/CAGAAA 1 -- us2k17Minor allele frequency- C:0.13NS EA WA CSA 517
    rs175028771,2
    F,H--33934826(+) AAAAAT/AAAAGT 1 -- us2k1 tfbs37Minor allele frequency- A:0.01NA NS EA 510
    rs1496455631,2
    C--33934826(+) AAAAA-/TAAAGT 1 -- us2k10--------
    rs1482839491,2
    --33934859(+) GCTACA/TAAAAC 1 -- us2k10--------
    rs354171,2
    C,F,H--33934957(+) GAGATG/ATTTGT 1 -- us2k19Minor allele frequency- A:0.17NS EA WA NA CSA 662
    rs1867675341,2
    --33934979(+) TTTTTA/GCTAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RXFP3 (33936491 - 33939023 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RXFP3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv462114CNV Loss19166990
    nsv462115CNV Loss19166990
    nsv830255CNV Loss17160897
    nsv522715CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609445    OMIM disorders: --

    5 diseases for RXFP3:    About MalaCards
    schizotypal personality disorder    personality disorder    endometrial carcinoma    schizophrenia
    neuronitis


    RXFP3 for disorders           About GeneDecksing


    Export disorders for RXFP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RXFP3 gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with RXFP3)
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    1. The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors. (PubMed id 10806363)1, 2, 9 Matsumoto M.... Furuichi K. (2000)
    2. Receptors for relaxin family peptides. (PubMed id 15956688)1, 3, 9 Bathgate R.A....Summers R.J. (2005)
    3. International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides. (PubMed id 16507880)1, 3 Bathgate R.A....Summers R.J. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein coupled receptor GPCR135. (PubMed id 14522968)1, 2 Liu C.... Lovenberg T.W. (2003)
    6. Identification of the domains in RXFP4 (GPCR142) responsible for the high affinity binding and agonistic activity of INSL5 at RXFP4 compared to RXFP3 (GPCR135). (PubMed id 18582868)1, 9 Zhu J....Liu C. (2008)
    7. H2 relaxin is a biased ligand relative to H3 relaxin at the relaxin family peptide receptor 3 (RXFP3). (PubMed id 20159943)1, 9 van der Westhuizen E.T....Summers R.J. (2010)
    8. Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7. (PubMed id 15465925)1, 9 Liu C....Lovenberg T.W. (2005)
    9. Responses of GPCR135 to human gene 3 (H3) relaxin in CHO-K1 cells determined by microphysiometry. (PubMed id 15956730)1, 9 Van der Westhuizen E.T....Summers R.J. (2005)
    10. Minimization of human relaxin-3 leading to high-affini ty analogues with increased selectivity for relaxin-family peptide 3 receptor (R XFP3) over RXFP1. (PubMed id 22257012)1 Shabanpoor F....Wade J.D. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51289 HGNC: 24883 AceView: SALPR Ensembl:ENSG00000182631 euGenes: HUgn51289
    ECgene: RXFP3 H-InvDB: RXFP3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RXFP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RXFP3 gene:
    Search GeneIP for patents involving RXFP3

    GeneCards and IP:
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