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Aliases for RXFP3 Gene

Aliases for RXFP3 Gene

  • Relaxin/Insulin Like Family Peptide Receptor 3 2 3
  • Relaxin Family Peptide Receptor 3 2 3 4
  • Somatostatin- And Angiotensin-Like Peptide Receptor 3 4
  • Relaxin/Insulin-Like Family Peptide Receptor 3 3 5
  • G-Protein Coupled Receptor GPCR135 3 4
  • G Protein-Coupled Receptor SALPR 3 4
  • Relaxin 3 Receptor 1 2 3
  • RLN3 Receptor 1 3 4
  • RLN3R1 3 4
  • SALPR 3 4
  • Somatostatin And Angiotensin-Like Peptide Receptor 3
  • G-Protein Coupled Receptor SALPR 3
  • GPCR135 3
  • RXFPR3 3

External Ids for RXFP3 Gene

Previous HGNC Symbols for RXFP3 Gene

  • RLN3R1

Summaries for RXFP3 Gene

GeneCards Summary for RXFP3 Gene

RXFP3 (Relaxin/Insulin Like Family Peptide Receptor 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled peptide receptor activity. An important paralog of this gene is ACKR3.

UniProtKB/Swiss-Prot for RXFP3 Gene

  • Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.

Gene Wiki entry for RXFP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RXFP3 Gene

Genomics for RXFP3 Gene

Regulatory Elements for RXFP3 Gene

Promoters for RXFP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RXFP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RXFP3 Gene

Chromosome:
5
Start:
33,936,386 bp from pter
End:
33,938,918 bp from pter
Size:
2,533 bases
Orientation:
Plus strand

Genomic View for RXFP3 Gene

Genes around RXFP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RXFP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RXFP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RXFP3 Gene

Proteins for RXFP3 Gene

  • Protein details for RXFP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSD7-RL3R1_HUMAN
    Recommended name:
    Relaxin-3 receptor 1
    Protein Accession:
    Q9NSD7
    Secondary Accessions:
    • Q14DA5

    Protein attributes for RXFP3 Gene

    Size:
    469 amino acids
    Molecular mass:
    51124 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RXFP3 Gene

Proteomics data for RXFP3 Gene at MOPED

Post-translational modifications for RXFP3 Gene

  • Glycosylation at Asn 36 and Asn 40
  • Modification sites at PhosphoSitePlus

Other Protein References for RXFP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RXFP3 Gene

Domains & Families for RXFP3 Gene

Gene Families for RXFP3 Gene

Protein Domains for RXFP3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RXFP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NSD7

UniProtKB/Swiss-Prot:

RL3R1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with RXFP3: view

Function for RXFP3 Gene

Molecular function for RXFP3 Gene

UniProtKB/Swiss-Prot Function:
Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.

Gene Ontology (GO) - Molecular Function for RXFP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 10806363
genes like me logo Genes that share ontologies with RXFP3: view
genes like me logo Genes that share phenotypes with RXFP3: view

Animal Models for RXFP3 Gene

MGI Knock Outs for RXFP3:

Animal Model Products

  • Taconic Biosciences Mouse Models for RXFP3

miRNA for RXFP3 Gene

miRTarBase miRNAs that target RXFP3

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RXFP3 Gene

Localization for RXFP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RXFP3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RXFP3 Gene COMPARTMENTS Subcellular localization image for RXFP3 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for RXFP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with RXFP3: view

Pathways & Interactions for RXFP3 Gene

genes like me logo Genes that share pathways with RXFP3: view

Pathways by source for RXFP3 Gene

Interacting Proteins for RXFP3 Gene

Gene Ontology (GO) - Biological Process for RXFP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA --
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA --
genes like me logo Genes that share ontologies with RXFP3: view

No data available for SIGNOR curated interactions for RXFP3 Gene

Drugs & Compounds for RXFP3 Gene

(10) Drugs for RXFP3 Gene - From: DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
[<sup>125</sup>I]H3-B/INSL5 A chimera Pharma Agonist 0
H3 relaxin Pharma Full agonist, Agonist 0
H3 relaxin (B chain) Pharma Full agonist, Agonist 0
H3 relaxin/INSL5 chimera Pharma Full agonist, Agonist 0

(3) Additional Compounds for RXFP3 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]H3 relaxin
Full agonist, Agonist
R3(BDelta23-27)R/I5 chimeric peptide
Antagonist
genes like me logo Genes that share compounds with RXFP3: view

Transcripts for RXFP3 Gene

mRNA/cDNA for RXFP3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RXFP3 Gene

Relaxin/insulin-like family peptide receptor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RXFP3 Gene

No ASD Table

Relevant External Links for RXFP3 Gene

GeneLoc Exon Structure for
RXFP3
ECgene alternative splicing isoforms for
RXFP3

Expression for RXFP3 Gene

mRNA expression in normal human tissues for RXFP3 Gene

mRNA differential expression in normal tissues according to GTEx for RXFP3 Gene

This gene is overexpressed in Adrenal Gland (x19.3), Brain - Hypothalamus (x7.0), and Pituitary (x4.4).

Protein differential expression in normal tissues from HIPED for RXFP3 Gene

This gene is overexpressed in Pancreas (60.5) and Heart (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RXFP3 Gene



SOURCE GeneReport for Unigene cluster for RXFP3 Gene Hs.170146

mRNA Expression by UniProt/SwissProt for RXFP3 Gene

Q9NSD7-RL3R1_HUMAN
Tissue specificity: Expressed predominantly in brain regions. Highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, quite low level in cerebellum. In peripheral tissues, relatively high levels in adrenal glands, low levels in pancreas, salivary gland, placenta, mammary gland and testis.
genes like me logo Genes that share expression patterns with RXFP3: view

Protein tissue co-expression partners for RXFP3 Gene

Primer Products

In Situ Assay Products

Orthologs for RXFP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RXFP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RXFP3 35
  • 99.22 (n)
  • 98.51 (a)
RXFP3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RXFP3 36
  • 89 (a)
OneToOne
RXFP3 35
  • 89.81 (n)
  • 89.74 (a)
dog
(Canis familiaris)
Mammalia RXFP3 35
  • 86.46 (n)
  • 82.31 (a)
RXFP3 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rxfp3 36
  • 86 (a)
OneToOne
Rxfp3 35
  • 84.86 (n)
  • 86.35 (a)
Rxfp3 16
oppossum
(Monodelphis domestica)
Mammalia RXFP3 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RXFP3 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rxfp3 35
  • 84.72 (n)
  • 85.93 (a)
chicken
(Gallus gallus)
Aves RXFP3 35
  • 74.64 (n)
  • 74.73 (a)
RXFP3 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rxfp3 35
  • 68.92 (n)
  • 74.23 (a)
zebrafish
(Danio rerio)
Actinopterygii rxfp3 36
  • 65 (a)
OneToOne
rxfp3 35
  • 66.85 (n)
  • 71.03 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8 36
  • 20 (a)
OneToMany
Species with no ortholog for RXFP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RXFP3 Gene

ENSEMBL:
Gene Tree for RXFP3 (if available)
TreeFam:
Gene Tree for RXFP3 (if available)

Paralogs for RXFP3 Gene

Paralogs for RXFP3 Gene

(5) SIMAP similar genes for RXFP3 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RXFP3 Gene

genes like me logo Genes that share paralogs with RXFP3: view

Variants for RXFP3 Gene

Sequence variations from dbSNP and Humsavar for RXFP3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs42868 -- 33,935,971(+) TGCAG(C/G)TGTAA upstream-variant-2KB
rs6861957 -- 33,936,275(+) ACTCT(A/G)CGATC upstream-variant-2KB
rs7702361 -- 33,935,838(+) AGAAC(A/C)ATTCC upstream-variant-2KB
rs7702600 -- 33,935,778(+) GAAAA(C/G)AGGCC upstream-variant-2KB
rs7717270 -- 33,934,989(+) ctttt(C/T)ttttc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RXFP3 Gene

Variant ID Type Subtype PubMed ID
nsv522715 CNV Gain 19592680
nsv462114 CNV Loss 19166990
nsv830255 CNV Loss 17160897
nsv462115 CNV Loss 19166990

Variation tolerance for RXFP3 Gene

Residual Variation Intolerance Score: 43.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RXFP3 Gene

HapMap Linkage Disequilibrium report
RXFP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RXFP3 Gene

Disorders for RXFP3 Gene

Relevant External Links for RXFP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RXFP3

No disorders were found for RXFP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RXFP3 Gene

Publications for RXFP3 Gene

  1. The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors. (PMID: 10806363) Matsumoto M. … Furuichi K. (Gene 2000) 3 4 23 67
  2. Receptors for relaxin family peptides. (PMID: 15956688) Bathgate R.A. … Summers R.J. (Ann. N. Y. Acad. Sci. 2005) 2 3 23
  3. H2 relaxin is a biased ligand relative to H3 relaxin at the relaxin family peptide receptor 3 (RXFP3). (PMID: 20159943) van der Westhuizen E.T. … Summers R.J. (Mol. Pharmacol. 2010) 3 23
  4. Identification of the domains in RXFP4 (GPCR142) responsible for the high affinity binding and agonistic activity of INSL5 at RXFP4 compared to RXFP3 (GPCR135). (PMID: 18582868) Zhu J. … Liu C. (Eur. J. Pharmacol. 2008) 3 23
  5. International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides. (PMID: 16507880) Bathgate R.A. … Summers R.J. (Pharmacol. Rev. 2006) 2 3

Products for RXFP3 Gene

Sources for RXFP3 Gene

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