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RXFP3 Gene

protein-coding   GIFtS: 55
GCID: GC05P033974

Relaxin/Insulin-Like Family Peptide Receptor 3

(Previous names: relaxin 3 receptor 1, relaxin family peptide receptor 3)
(Previous symbol: RLN3R1)
  See RXFP3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Relaxin/Insulin-Like Family Peptide Receptor 31 2     G-Protein Coupled Receptor GPCR1352 3
RLN3R11 2 3 5     RLN3 Receptor 12 3
Relaxin Family Peptide Receptor 31 2 3     GPCR1352 5
SALPR2 3 5     RXFPR32
Relaxin 3 Receptor 11 2     G-Protein Coupled Receptor SALPR2
G Protein-Coupled Receptor SALPR2 3     Relaxin-3 Receptor 12
Somatostatin- And Angiotensin-Like Peptide Receptor2 3     Somatostatin And Angiotensin-Like Peptide Receptor2

External Ids:    HGNC: 248831   Entrez Gene: 512892   Ensembl: ENSG000001826317   OMIM: 6094455   UniProtKB: Q9NSD73   

Export aliases for RXFP3 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RXFP3 Gene:
RXFP3 (relaxin/insulin-like family peptide receptor 3) is a protein-coding gene. Diseases associated with RXFP3 include schizotypal personality disorder. GO annotations related to this gene include N-formyl peptide receptor activity and G-protein coupled receptor activity. An important paralog of this gene is BDKRB1.

UniProtKB/Swiss-Prot: RL3R1_HUMAN, Q9NSD7
Function: Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation

Gene Wiki entry for RXFP3 (Relaxin/insulin-like family peptide receptor 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_006576.17  NT_187551.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the RXFP3 gene promoter:
         AML1a   RREB-1   NRSF form 1   AP-4   STAT5A   NRSF form 2   Pax-3   c-Myb   ZIC2/Zic2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRXFP3 promoter sequence
   Search Chromatin IP Primers for RXFP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RXFP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.1-p14   Ensembl cytogenetic band:  5p13.2   HGNC cytogenetic band: 5p15.1-p14

RXFP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RXFP3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P033974:  view genomic region     (about GC identifiers)

Start:
33,936,491 bp from pter      End:
33,939,023 bp from pter
Size:
2,533 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RL3R1_HUMAN, Q9NSD7 (See protein sequence)
Recommended Name: Relaxin-3 receptor 1  
Size: 469 amino acids; 51124 Da
Secondary accessions: Q14DA5

Explore the universe of human proteins at neXtProt for RXFP3: NX_Q9NSD7

Explore proteomics data for RXFP3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn36, Asn40
  • Modification sites at PhosphoSitePlus

  • See RXFP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057652.1  
    ENSEMBL proteins: 
     ENSP00000328708  
    Reactome Protein details: Q9NSD7

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    Cloud-Clone Corp. Proteins for RXFP3

     
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    antibodies-online proteins for RXFP3 (3 products) 

     
    antibodies-online peptides for RXFP3

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    antibodies-online antibodies for RXFP3 (49 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RXFP: GPCR / Class A : Relaxin family peptide receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: RXFP3 receptor
    Relaxin family peptide receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000826 Formyl_pep_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9NSD7

    ProtoNet protein and cluster: Q9NSD7

    UniProtKB/Swiss-Prot: RL3R1_HUMAN, Q9NSD7
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with RXFP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RL3R1_HUMAN, Q9NSD7
    Function: Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS10806363
    GO:0004982N-formyl peptide receptor activity IEA--
    GO:0008528G-protein coupled peptide receptor activity ----
         
    Find genes that share ontologies with RXFP3           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RXFP3

    miRNA
    Products:
        
    miRTarBase miRNAs that target RXFP3:
    hsa-mir-26b-5p (MIRT029856), hsa-mir-335-5p (MIRT018507)

    Block miRNA regulation of human, mouse, rat RXFP3 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate RXFP3:
    hsa-miR-1224-3p hsa-miR-1260b hsa-miR-1260
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RXFP3

    Gene Editing
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    Sino Biological Human cDNA Clone for RXFP3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RXFP3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RXFP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RL3R1_HUMAN, Q9NSD7: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS10806363
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with RXFP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RXFP3 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    Relaxin receptors0.00
    Peptide ligand-binding receptors0.60
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3GPCRs, Other
    GPCRs, Other


    Find genes that share SuperPaths with RXFP3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RXFP3
        GPCRs, Other


    2 Reactome Pathways for RXFP3
        Relaxin receptors
    G alpha (i) signalling events


        Pathway & Disease-focused RT2 Profiler PCR Array including RXFP3: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RXFP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RXFP3 (ENSP000003287084) via UniProtKB, MINT, STRING, and/or I2D (see all 144)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY2ENSP000003429524STRING: ENSP00000342952
    DRD4ENSP000001761834STRING: ENSP00000176183
    GALENSP000002656434STRING: ENSP00000265643
    GNAI2ENSP000003129994STRING: ENSP00000312999
    GPR55ENSP000003758934STRING: ENSP00000375893
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS10806363
    GO:0032467positive regulation of cytokinesis IMP--
    GO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA--

    Find genes that share ontologies with RXFP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RXFP3 (RL3R1)

    1 HMDB Compound for RXFP3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    8 IUPHAR Ligands for RXFP3 (RXFP3 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    H3 relaxin
    AgonistFull agonist9.4 - 9.615367576 14522968
    [125I]H3 relaxin
    AgonistFull agonist9.514522968
    [125I]H3-B/INSL5 A chimera
    AgonistAgonist9.315465925
    H3 relaxin/INSL5 chimera
    AgonistFull agonist9.315465925
    R3(BDelta23-27)R/I5 chimeric peptide
    AntagonistAntagonist9.217606621
    R3-B1-22R
    AntagonistAntagonist7.421384867
    H3 relaxin (B chain)
    AgonistFull agonist6.914522968
    INSL5
    AntagonistAntagonist6.315525639

    1 Novoseek inferred chemical compound relationship for RXFP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 15.3 3 14522967 (1), 17293890 (1)



    Find genes that share compounds with RXFP3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RXFP3 gene: 
    NM_016568.3  

    Unigene Cluster for RXFP3:

    Relaxin/insulin-like family peptide receptor 3
    Hs.170146  [show with all ESTs]
    Unigene Representative Sequence: NM_016568
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000330120(uc003jic.2)
    miRNA
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    hsa-miR-1224-3p hsa-miR-1260b hsa-miR-1260
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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      QuantiTect SYBR Green Assays in human, mouse, rat RXFP3
      QuantiFast Probe-based Assays in human, mouse, rat RXFP3

    Additional mRNA sequence: 

    AY394501.1 BC095526.1 BC113438.1 BC113440.1 D88437.1 

    1 DOTS entry:

    DT.40294969 

    6 AceView cDNA sequences:

    AY394501 CN839244 CN835032 CN835129 NM_016568 D88437 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RXFP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCCCCTTCA
    RXFP3 Expression
    About this image


    RXFP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             Septum   
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
    RXFP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RXFP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.170146

    UniProtKB/Swiss-Prot: RL3R1_HUMAN, Q9NSD7
    Tissue specificity: Expressed predominantly in brain regions. Highest expression in substantia nigra and
    pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, quite low level
    in cerebellum. In peripheral tissues, relatively high levels in adrenal glands, low levels in pancreas, salivary
    gland, placenta, mammary gland and testis

        Pathway & Disease-focused RT2 Profiler PCR Array including RXFP3: 
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RXFP3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rxfp31 , 5 relaxin family peptide receptor 31, 5 84.86(n)1
    86.35(a)1
      15 (5.42 cM)5
    2393361  NM_178717.31  NP_848832.11 
     110337175 
    chicken
    (Gallus gallus)
    Aves RXFP31 relaxin/insulin-like family peptide receptor 3 74.64(n)
    74.73(a)
      431664  XM_004937174.1  XP_004937231.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rxfp31 relaxin/insulin-like family peptide receptor 3 68.92(n)
    74.23(a)
      100489869  XM_002941579.2  XP_002941625.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rxfp31 relaxin/insulin-like family peptide receptor 3 66.85(n)
    71.03(a)
      794924  NM_001128788.2  NP_001122260.1 


    ENSEMBL Gene Tree for RXFP3 (if available)
    TreeFam Gene Tree for RXFP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RXFP3 gene
    BDKRB12  AGTR22  GPR252  AGTR12  APLNR2  BDKRB22  ACKR32  GPR152  
    RXFP42  GPR1822  
    5 SIMAP similar genes for RXFP3 using alignment to 2 protein entries:     RL3R1_HUMAN (see all proteins):
    CMKLR1    GPR18    RXFP4    AGTR1    SSTR2

    Find genes that share paralogs with RXFP3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RXFP3
    PGOHUM00000247195


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RXFP3 (see all 155)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs779026171,2
    C,F--33934549(+) ATCAGG/ACCCCT 1 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1831967351,2
    --33934565(+) TTTTTC/TATAAA 1 -- us2k10--------
    rs572466941,2
    C--33934693(+) AAATTT/GAACAG 1 -- us2k14Minor allele frequency- G:0.08WA NA EA 360
    rs1459996211,2
    --33934706(+) GAGAGC/TTTTCA 1 -- us2k10--------
    rs100457591,2
    C,F,H--33934758(+) AATATT/CAGAAA 1 -- us2k17Minor allele frequency- C:0.13NS EA WA CSA 517
    rs175028771,2
    F,H--33934826(+) AAAAAT/AAAAGT 1 -- us2k1 tfbs37Minor allele frequency- A:0.01NA NS EA 510
    rs1496455631,2
    C--33934826(+) AAAAA-/TAAAGT 1 -- us2k10--------
    rs1482839491,2
    --33934859(+) GCTACA/TAAAAC 1 -- us2k10--------
    rs354171,2
    C,F,H--33934957(+) GAGATG/ATTTGT 1 -- us2k19Minor allele frequency- A:0.17NS EA WA NA CSA 662
    rs1867675341,2
    --33934979(+) TTTTTA/GCTAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RXFP3 (33936491 - 33939023 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RXFP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv462114CNV Loss19166990
    nsv462115CNV Loss19166990
    nsv830255CNV Loss17160897
    nsv522715CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RXFP3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609445    OMIM disorders: --

    1 disease for RXFP3:    
    About MalaCards
    schizotypal personality disorder


    Find genes that share disorders with RXFP3           About GenesLikeMe


    Export disorders for RXFP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RXFP3 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with RXFP3)
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    1. The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors. (PubMed id 10806363)1, 2, 9 Matsumoto M.... Furuichi K. (Gene 2000)
    2. Receptors for relaxin family peptides. (PubMed id 15956688)1, 3, 9 Bathgate R.A....Summers R.J. (Ann. N. Y. Acad. Sci. 2005)
    3. International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides. (PubMed id 16507880)1, 3 Bathgate R.A....Summers R.J. (Pharmacol. Rev. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein coupled receptor GPCR135. (PubMed id 14522968)1, 2 Liu C.... Lovenberg T.W. (J. Biol. Chem. 2003)
    6. Identification of the domains in RXFP4 (GPCR142) responsible for the high affinity binding and agonistic activity of INSL5 at RXFP4 compared to RXFP3 (GPCR135). (PubMed id 18582868)1, 9 Zhu J....Liu C. (Eur. J. Pharmacol. 2008)
    7. H2 relaxin is a biased ligand relative to H3 relaxin at the relaxin family peptide receptor 3 (RXFP3). (PubMed id 20159943)1, 9 van der Westhuizen E.T....Summers R.J. (Mol. Pharmacol. 2010)
    8. Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7. (PubMed id 15465925)1, 9 Liu C....Lovenberg T.W. (Mol. Pharmacol. 2005)
    9. Responses of GPCR135 to human gene 3 (H3) relaxin in CHO-K1 cells determined by microphysiometry. (PubMed id 15956730)1, 9 Van der Westhuizen E.T....Summers R.J. (Ann. N. Y. Acad. Sci. 2005)
    10. Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1. (PubMed id 22257012)1 Shabanpoor F....Wade J.D. (J. Med. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51289 HGNC: 24883 AceView: SALPR Ensembl:ENSG00000182631 euGenes: HUgn51289
    ECgene: RXFP3 H-InvDB: RXFP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RXFP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RXFP3 gene:
    Search GeneIP for patents involving RXFP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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