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Aliases for RXFP3 Gene

Aliases for RXFP3 Gene

  • Relaxin/Insulin-Like Family Peptide Receptor 3 2 3
  • Relaxin Family Peptide Receptor 3 2 3 4
  • RLN3R1 3 4 6
  • SALPR 3 4 6
  • Somatostatin- And Angiotensin-Like Peptide Receptor 3 4
  • G-Protein Coupled Receptor GPCR135 3 4
  • G Protein-Coupled Receptor SALPR 3 4
  • Relaxin 3 Receptor 1 2 3
  • RLN3 Receptor 1 3 4
  • GPCR135 3 6
  • Somatostatin And Angiotensin-Like Peptide Receptor 3
  • G-Protein Coupled Receptor SALPR 3
  • Relaxin-3 Receptor 1 3
  • RXFPR3 3

External Ids for RXFP3 Gene

Previous HGNC Symbols for RXFP3 Gene

  • RLN3R1

Summaries for RXFP3 Gene

GeneCards Summary for RXFP3 Gene

RXFP3 (Relaxin/Insulin-Like Family Peptide Receptor 3) is a Protein Coding gene. Diseases associated with RXFP3 include schizotypal personality disorder. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and N-formyl peptide receptor activity. An important paralog of this gene is ACKR3.

UniProtKB/Swiss-Prot for RXFP3 Gene

  • Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.

Gene Wiki entry for RXFP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RXFP3 Gene

Genomics for RXFP3 Gene

Regulatory Elements for RXFP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RXFP3 Gene

33,936,386 bp from pter
33,938,918 bp from pter
2,533 bases
Plus strand

Genomic View for RXFP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RXFP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RXFP3 Gene

Proteins for RXFP3 Gene

  • Protein details for RXFP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Relaxin-3 receptor 1
    Protein Accession:
    Secondary Accessions:
    • Q14DA5

    Protein attributes for RXFP3 Gene

    469 amino acids
    Molecular mass:
    51124 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RXFP3 Gene

Proteomics data for RXFP3 Gene at MOPED

Post-translational modifications for RXFP3 Gene

  • Glycosylation at Asn36 and Asn40
  • Modification sites at PhosphoSitePlus

Other Protein References for RXFP3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RXFP3 Gene

Domains for RXFP3 Gene

Gene Families for RXFP3 Gene

  • RXFP :GPCR / Class A : Relaxin family peptide receptors

Protein Domains for RXFP3 Gene


Suggested Antigen Peptide Sequences for RXFP3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9NSD7
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with RXFP3: view

Function for RXFP3 Gene

Molecular function for RXFP3 Gene

UniProtKB/Swiss-Prot Function:
Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.

Gene Ontology (GO) - Molecular Function for RXFP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 10806363
GO:0008528 G-protein coupled peptide receptor activity IEA --
genes like me logo Genes that share ontologies with RXFP3: view

Animal Model Products

miRNA for RXFP3 Gene

miRTarBase miRNAs that target RXFP3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RXFP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RXFP3 Gene

Localization for RXFP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RXFP3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for RXFP3 Gene COMPARTMENTS Subcellular localization image for RXFP3 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for RXFP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10806363
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with RXFP3: view

Pathways for RXFP3 Gene

genes like me logo Genes that share pathways with RXFP3: view

Pathways by source for RXFP3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for RXFP3 Gene

Gene Ontology (GO) - Biological Process for RXFP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 10806363
GO:0032467 positive regulation of cytokinesis IMP 22888021
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA --
genes like me logo Genes that share ontologies with RXFP3: view

Compounds for RXFP3 Gene

(1) HMDB Compounds for RXFP3 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP

(8) IUPHAR Ligand for RXFP3 Gene

Ligand Type Action Affinity Pubmed IDs
[125I]H3 relaxin Agonist Full agonist 9.7
H3 relaxin/INSL5 chimera Agonist Full agonist 9.3
[125I]H3-B/INSL5 A chimera Agonist Agonist 8.9
INSL5 Agonist Full agonist 8.8
R3(BDelta23-27)R/I5 chimeric peptide Antagonist Antagonist 8.64
R3-B1-22R Antagonist Antagonist 7.4
H3 relaxin Agonist Full agonist 7
H3 relaxin (B chain) Agonist Full agonist 6.9

(1) Novoseek inferred chemical compound relationships for RXFP3 Gene

Compound -log(P) Hits PubMed IDs
adenylate 15.3 2
genes like me logo Genes that share compounds with RXFP3: view

Transcripts for RXFP3 Gene

mRNA/cDNA for RXFP3 Gene

(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RXFP3 Gene

Relaxin/insulin-like family peptide receptor 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RXFP3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RXFP3 Gene

No ASD Table

Relevant External Links for RXFP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RXFP3 Gene

mRNA expression in normal human tissues for RXFP3 Gene

mRNA differential expression in normal tissues according to GTEx for RXFP3 Gene

This gene is overexpressed in Adrenal Gland (19.3), Brain - Hypothalamus (7.0), and Pituitary (4.4).

Protein differential expression in normal tissues for RXFP3 Gene

This gene is overexpressed in Pancreas (60.5) and Heart (8.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RXFP3 Gene

SOURCE GeneReport for Unigene cluster for RXFP3 Gene Hs.170146

mRNA Expression by UniProt/SwissProt for RXFP3 Gene

Tissue specificity: Expressed predominantly in brain regions. Highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, quite low level in cerebellum. In peripheral tissues, relatively high levels in adrenal glands, low levels in pancreas, salivary gland, placenta, mammary gland and testis
genes like me logo Genes that share expressions with RXFP3: view

Expression partners for RXFP3 Gene

In Situ Assay Products

Orthologs for RXFP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RXFP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RXFP3 35
  • 89.81 (n)
  • 89.74 (a)
RXFP3 36
  • 89 (a)
(Canis familiaris)
Mammalia RXFP3 35
  • 86.46 (n)
  • 82.31 (a)
RXFP3 36
  • 85 (a)
(Mus musculus)
Mammalia Rxfp3 35
  • 84.86 (n)
  • 86.35 (a)
Rxfp3 16
Rxfp3 36
  • 86 (a)
(Pan troglodytes)
Mammalia RXFP3 35
  • 99.22 (n)
  • 98.51 (a)
RXFP3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rxfp3 35
  • 84.72 (n)
  • 85.93 (a)
(Monodelphis domestica)
Mammalia RXFP3 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia RXFP3 36
  • 70 (a)
(Gallus gallus)
Aves RXFP3 35
  • 74.64 (n)
  • 74.73 (a)
RXFP3 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rxfp3 35
  • 68.92 (n)
  • 74.23 (a)
(Danio rerio)
Actinopterygii rxfp3 35
  • 66.85 (n)
  • 71.03 (a)
rxfp3 36
  • 65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8 36
  • 20 (a)
Species with no ortholog for RXFP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RXFP3 Gene

Gene Tree for RXFP3 (if available)
Gene Tree for RXFP3 (if available)

Paralogs for RXFP3 Gene

Paralogs for RXFP3 Gene

Selected SIMAP similar genes for RXFP3 Gene using alignment to 2 proteins: Pseudogenes for RXFP3 Gene

genes like me logo Genes that share paralogs with RXFP3: view

Variants for RXFP3 Gene

Sequence variations from dbSNP and Humsavar for RXFP3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs35416 -- 33,935,376(+) TTCCA(C/T)TGGTC upstream-variant-2KB
rs35417 -- 33,934,852(+) GAGAT(A/G)TTTGT upstream-variant-2KB
rs42868 -- 33,935,971(+) TGCAG(C/G)TGTAA upstream-variant-2KB
rs171631 -- 33,938,870(+) TAACA(A/C)CTGTC utr-variant-3-prime
rs3832336 -- 33,938,234(-) CCCCC(-/C)AGCCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RXFP3 Gene

Variant ID Type Subtype PubMed ID
nsv522715 CNV Gain 19592680
nsv462114 CNV Loss 19166990
nsv830255 CNV Loss 17160897
nsv462115 CNV Loss 19166990

Relevant External Links for RXFP3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RXFP3 Gene

Disorders for RXFP3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for RXFP3 Gene in MalaCards »

(1) Diseases for RXFP3 Gene including...

genes like me logo Genes that share disorders with RXFP3: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RXFP3 Gene

Publications for RXFP3 Gene

  1. The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors. (PMID: 10806363) Matsumoto M. … Furuichi K. (Gene 2000) 3 4 23
  2. Receptors for relaxin family peptides. (PMID: 15956688) Bathgate R.A. … Summers R.J. (Ann. N. Y. Acad. Sci. 2005) 2 3 23
  3. Responses of GPCR135 to human gene 3 (H3) relaxin in CHO-K1 cells determined by microphysiometry. (PMID: 15956730) Van der Westhuizen E.T. … Summers R.J. (Ann. N. Y. Acad. Sci. 2005) 3 23
  4. Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7. (PMID: 15465925) Liu C. … Lovenberg T.W. (Mol. Pharmacol. 2005) 3 23
  5. Identification of the domains in RXFP4 (GPCR142) responsible for the high affinity binding and agonistic activity of INSL5 at RXFP4 compared to RXFP3 (GPCR135). (PMID: 18582868) Zhu J. … Liu C. (Eur. J. Pharmacol. 2008) 3 23

Products for RXFP3 Gene

Sources for RXFP3 Gene

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