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Aliases for RXFP1 Gene

Aliases for RXFP1 Gene

  • Relaxin/Insulin-Like Family Peptide Receptor 1 2 3
  • LGR7 3 4 6
  • Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 7 2 3
  • Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 7 4
  • Relaxin Family Peptide Receptor 1 4
  • Relaxin Receptor 1 3
  • RXFPR1 3

External Ids for RXFP1 Gene

Previous Symbols for RXFP1 Gene

  • LGR7

Summaries for RXFP1 Gene

Entrez Gene Summary for RXFP1 Gene

  • This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for RXFP1 Gene

RXFP1 (Relaxin/Insulin-Like Family Peptide Receptor 1) is a Protein Coding gene. Diseases associated with RXFP1 include endometriosis and placenta accreta. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include G-protein coupled receptor activity and hormone binding. An important paralog of this gene is LGR6.

UniProtKB/Swiss-Prot for RXFP1 Gene

  • Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP

Gene Wiki entry for RXFP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RXFP1 Gene

Genomics for RXFP1 Gene

Genomic Location for RXFP1 Gene

Start:
158,315,311 bp from pter
End:
158,653,372 bp from pter
Size:
338,062 bases
Orientation:
Plus strand

Genomic View for RXFP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RXFP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RXFP1 Gene

Regulatory Elements for RXFP1 Gene

Proteins for RXFP1 Gene

  • Protein details for RXFP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBX9-RXFP1_HUMAN
    Recommended name:
    Relaxin receptor 1
    Protein Accession:
    Q9HBX9
    Secondary Accessions:
    • B4DHD1
    • B4DTV2
    • Q2M215
    • Q3KU24
    • Q3KU25
    • Q3KU26

    Protein attributes for RXFP1 Gene

    Size:
    757 amino acids
    Molecular mass:
    86975 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RXFP1 Gene

    Alternative splice isoforms for RXFP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RXFP1 Gene

Proteomics data for RXFP1 Gene at MOPED

Post-translational modifications for RXFP1 Gene

  • Glycosylation at Asn36, Asn127, Asn264, Asn272, Asn325, and Asn368

No data available for DME Specific Peptides for RXFP1 Gene

Domains for RXFP1 Gene

Gene Families for RXFP1 Gene

HGNC:
  • RXFP :GPCR / Class A : Relaxin family peptide receptors
IUPHAR :

UniProtKB/Swiss-Prot:

RXFP1_HUMAN
Domain:
  • Contains 1 LDL-receptor class A domain.:
    • Q9HBX9
  • Contains 1 LRRNT domain.:
    • Q9HBX9
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q9HBX9
Similarity:
  • Contains 9 LRR (leucine-rich) repeats.:
    • Q9HBX9
genes like me logo Genes that share domains with RXFP1: view

Function for RXFP1 Gene

Molecular function for RXFP1 Gene

UniProtKB/Swiss-Prot Function: Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP

Gene Ontology (GO) - Molecular Function for RXFP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IDA 11809971
GO:0005515 protein binding IPI 20664520
GO:0042562 hormone binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RXFP1: view
genes like me logo Genes that share phenotypes with RXFP1: view

Animal Models for RXFP1 Gene

MGI Knock Outs for RXFP1:

miRNA for RXFP1 Gene

miRTarBase miRNAs that target RXFP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RXFP1 Gene

Localization for RXFP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RXFP1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RXFP1 Gene COMPARTMENTS Subcellular localization image for RXFP1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RXFP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RXFP1: view

Pathways for RXFP1 Gene

genes like me logo Genes that share pathways with RXFP1: view

Pathways by source for RXFP1 Gene

Gene Ontology (GO) - Biological Process for RXFP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway --
GO:0007567 parturition --
GO:0030154 cell differentiation --
GO:0030198 extracellular matrix organization --
genes like me logo Genes that share ontologies with RXFP1: view

Compounds for RXFP1 Gene

(1) HMDB Compounds for RXFP1 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4

(10) IUPHAR Ligand for RXFP1 Gene

Ligand Type Action Affinity Pubmed IDs
[33P]H2 relaxin Agonist Full agonist 9.2
europium-labelled H2 relaxin Agonist Full agonist 9
H1 relaxin Agonist Full agonist 8.8
H2 relaxin Agonist Full agonist 8.3
relaxin Agonist Full agonist 7.9
relaxin Agonist Full agonist 7.9
relaxin Agonist Full agonist 7.9
H3 relaxin Agonist Full agonist 7
B-R13/17K H2 relaxin Antagonist Antagonist 6.7
LGR7-truncate Antagonist Antagonist

(3) Novoseek inferred chemical compound relationships for RXFP1 Gene

Compound -log(P) Hits PubMed IDs
adenylate 23.3 1
tyrosine 0 1
estrogen 0 3
genes like me logo Genes that share compounds with RXFP1: view

Transcripts for RXFP1 Gene

Unigene Clusters for RXFP1 Gene

Relaxin/insulin-like family peptide receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RXFP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5: - - - - -
SP6: - - - - - -
SP7:

Relevant External Links for RXFP1 Gene

GeneLoc Exon Structure for
RXFP1
ECgene alternative splicing isoforms for
RXFP1

Expression for RXFP1 Gene

mRNA expression in normal human tissues for RXFP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RXFP1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (10.5), Brain - Anterior cingulate cortex (BA24) (9.4), and Brain - Cortex (8.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RXFP1 Gene

SOURCE GeneReport for Unigene cluster for RXFP1 Gene Hs.591686

mRNA Expression by UniProt/SwissProt for RXFP1 Gene

Q9HBX9-RXFP1_HUMAN
Tissue specificity: Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen.
genes like me logo Genes that share expressions with RXFP1: view

Orthologs for RXFP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RXFP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RXFP1 36
  • 99.74 (n)
  • 99.62 (a)
RXFP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RXFP1 36
  • 88.99 (n)
  • 88.24 (a)
RXFP1 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RXFP1 36
  • 92.16 (n)
  • 92.31 (a)
RXFP1 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rxfp1 36
  • 85.73 (n)
  • 85.07 (a)
Rxfp1 16
Rxfp1 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RXFP1 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 69 (a)
OneToMany
-- 37
  • 86 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rxfp1 36
  • 85.25 (n)
  • 86.13 (a)
chicken
(Gallus gallus)
Aves RXFP1 36
  • 76.1 (n)
  • 77.38 (a)
RXFP1 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RXFP1 37
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rxfp1 36
  • 71.5 (n)
  • 73.46 (a)
Str.18185 36
zebrafish
(Danio rerio)
Actinopterygii rxfp1 36
  • 64.52 (n)
  • 64.57 (a)
rxfp1 37
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta GPRGPH 36
  • 43.19 (n)
  • 34.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34411 36
  • 44.11 (n)
  • 33.99 (a)
CG34411 37
  • 28 (a)
ManyToMany
Lgr3 37
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 16 (a)
ManyToMany
-- 37
  • 16 (a)
ManyToMany
-- 37
  • 19 (a)
ManyToMany
-- 37
  • 21 (a)
ManyToMany
-- 37
  • 23 (a)
ManyToMany
-- 37
  • 20 (a)
ManyToMany
-- 37
  • 23 (a)
ManyToMany
-- 37
  • 24 (a)
ManyToMany
-- 37
  • 15 (a)
ManyToMany
-- 37
  • 16 (a)
ManyToMany
-- 37
  • 21 (a)
ManyToMany
-- 37
  • 19 (a)
ManyToMany
-- 37
  • 21 (a)
ManyToMany
-- 37
  • 18 (a)
ManyToMany
-- 37
  • 16 (a)
ManyToMany
-- 37
  • 26 (a)
ManyToMany
-- 37
  • 13 (a)
ManyToMany
-- 37
  • 19 (a)
ManyToMany
-- 37
  • 15 (a)
ManyToMany
-- 37
  • 18 (a)
ManyToMany
-- 37
  • 17 (a)
ManyToMany
-- 37
  • 17 (a)
ManyToMany
-- 37
  • 17 (a)
ManyToMany
-- 37
  • 20 (a)
ManyToMany
-- 37
  • 20 (a)
ManyToMany
-- 37
  • 20 (a)
ManyToMany
-- 37
  • 20 (a)
ManyToMany
-- 37
  • 21 (a)
ManyToMany
-- 37
  • 17 (a)
ManyToMany
Species with no ortholog for RXFP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RXFP1 Gene

ENSEMBL:
Gene Tree for RXFP1 (if available)
TreeFam:
Gene Tree for RXFP1 (if available)

Paralogs for RXFP1 Gene

Paralogs for RXFP1 Gene

Selected SIMAP similar genes for RXFP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RXFP1: view

Variants for RXFP1 Gene

Sequence variations from dbSNP and Humsavar for RXFP1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs745279 -- 158,559,722(-) ATGAA(A/G)AATTT intron-variant
rs885180 -- 158,537,448(+) GGTGG(A/C)AGACT intron-variant
rs936092 -- 158,560,309(-) GGTCC(A/C)TGTTG intron-variant
rs936093 -- 158,559,878(-) TGTTT(C/T)TCTGA intron-variant
rs936094 -- 158,523,162(+) TAAAT(C/T)GCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RXFP1 Gene

Variant ID Type Subtype PubMed ID
nsv880895 CNV Gain 21882294
nsv830124 CNV Gain 17160897
esv2669435 CNV Deletion 23128226
esv2728610 CNV Deletion 23290073

Relevant External Links for RXFP1 Gene

HapMap Linkage Disequilibrium report
RXFP1

Disorders for RXFP1 Gene

(2) Novoseek inferred disease relationships for RXFP1 Gene

Disease -log(P) Hits PubMed IDs
necrosis 0 1
tumors 0 1

Relevant External Links for RXFP1

Genetic Association Database (GAD)
RXFP1
Human Genome Epidemiology (HuGE) Navigator
RXFP1
genes like me logo Genes that share disorders with RXFP1: view

No data available for UniProtKB/Swiss-Prot for RXFP1 Gene

Publications for RXFP1 Gene

  1. H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2. (PMID: 12506116) Sudo S. … Hsueh A.J.W. (J. Biol. Chem. 2003) 3 4 23
  2. Receptors for relaxin family peptides. (PMID: 15956688) Bathgate R.A. … Summers R.J. (Ann. N. Y. Acad. Sci. 2005) 2 3 23
  3. The NMR solution structure of the relaxin (RXFP1) receptor lipoprotein receptor class A module and identification of key residues in the N-terminal region of the module that mediate receptor activation. (PMID: 17148455) Hopkins E.J. … Gooley P.R. (J. Biol. Chem. 2007) 3 4 23
  4. Identification of the N-linked glycosylation sites of the human relaxin receptor and effect of glycosylation on receptor function. (PMID: 18533687) Yan Y. … Bathgate R.A. (Biochemistry 2008) 3 4 23
  5. The human LGR7 low-density lipoprotein class A module requires calcium for structure. (PMID: 15956684) Hopkins E.J. … Gooley P.R. (Ann. N. Y. Acad. Sci. 2005) 3 23

Products for RXFP1 Gene

Sources for RXFP1 Gene

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