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RXFP1 Gene

protein-coding   GIFtS: 60
GCID: GC04P159236

Relaxin/Insulin-Like Family Peptide Receptor 1

(Previous name: leucine-rich repeat-containing G protein-coupled receptor...)
(Previous symbol: LGR7)
  See RXFP1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Relaxin/Insulin-Like Family Peptide Receptor 11 2     Relaxin Receptor 12
LGR71 2 3 5     Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 73
Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 71 2     Relaxin Family Peptide Receptor 13
RXFPR12     

External Ids:    HGNC: 197181   Entrez Gene: 593502   Ensembl: ENSG000001715097   OMIM: 6066545   UniProtKB: Q9HBX93   

Export aliases for RXFP1 gene to outside databases

Previous GC identifers: GC04P159655 GC04P159435 GC04P155192


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RXFP1 Gene:
This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane
receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a
receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided
by RefSeq, Dec 2011)

GeneCards Summary for RXFP1 Gene:
RXFP1 (relaxin/insulin-like family peptide receptor 1) is a protein-coding gene. Diseases associated with RXFP1 include placenta accreta, and endometriosis. GO annotations related to this gene include G-protein coupled receptor activity and hormone binding. An important paralog of this gene is LHCGR.

UniProtKB/Swiss-Prot: RXFP1_HUMAN, Q9HBX9
Function: Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of
adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that
inhibits the activity of a phosphodiesterase that degrades cAMP

Gene Wiki entry for RXFP1 (Relaxin/insulin-like family peptide receptor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RXFP1 gene promoter:
         TBP   STAT5B   LHX3b/Lhx3b   Tal-1beta   E47   MEF-2A   MZF-1   LHX3a/Lhx3a   STAT3   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRXFP1 promoter sequence
   Search Chromatin IP Primers for RXFP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RXFP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q32.1   Ensembl cytogenetic band:  4q32.1   HGNC cytogenetic band: 4q31.3

RXFP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RXFP1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P159236:  view genomic region     (about GC identifiers)

Start:
159,236,463 bp from pter      End:
159,574,524 bp from pter
Size:
338,062 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RXFP1_HUMAN, Q9HBX9 (See protein sequence)
Recommended Name: Relaxin receptor 1  
Size: 757 amino acids; 86975 Da
2 PDB 3D structures from and Proteopedia for RXFP1:
2JM4 (3D)        2M7P (3D)    
Secondary accessions: B4DTV2 Q2M215 Q3KU24 Q3KU25 Q3KU26
Alternative splicing: 4 isoforms:  Q9HBX9-1   Q9HBX9-2   Q9HBX9-3   Q9HBX9-4   

Explore the universe of human proteins at neXtProt for RXFP1: NX_Q9HBX9

Explore proteomics data for RXFP1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn36, Asn127, Asn264, Asn272, Asn325, Asn368

  • See RXFP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001240656.1  NP_001240657.1  NP_001240658.1  NP_001240659.1  NP_001240661.1  NP_001240662.1  NP_067647.2  

    ENSEMBL proteins: 
     ENSP00000423306   ENSP00000303248   ENSP00000432036   ENSP00000434475   ENSP00000345889  
     ENSP00000420712   ENSP00000405841   ENSP00000414885  
    Reactome Protein details: Q9HBX9

    RXFP1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for RXFP1
    OriGene Custom MassSpec
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    Novus Biologicals RXFP1 Proteins
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    Cloud-Clone Corp. Proteins for RXFP1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RXFP: GPCR / Class A : Relaxin family peptide receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: RXFP1 receptor
    Relaxin family peptide receptors

    Selected InterPro protein domains (see all 8):
     IPR002172 LDrepeatLR_classA_rpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000372 LRR-contain_N
     IPR023415 LDLR_class-A_CS
     IPR001611 Leu-rich_rpt

    Graphical View of Domain Structure for InterPro Entry Q9HBX9

    ProtoNet protein and cluster: Q9HBX9

    3 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB002172 Low density lipoprotein-receptor
    IPB008112 Relaxin receptor family signature


    UniProtKB/Swiss-Prot: RXFP1_HUMAN, Q9HBX9
    Similarity: Belongs to the G-protein coupled receptor 1 family
    Similarity: Contains 1 LDL-receptor class A domain
    Similarity: Contains 9 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRNT domain


    Find genes that share domains with RXFP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RXFP1_HUMAN, Q9HBX9
    Function: Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of
    adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that
    inhibits the activity of a phosphodiesterase that degrades cAMP

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IDA11809971
    GO:0005515protein binding IPI--
    GO:0042562hormone binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with RXFP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RXFP1:
     Increased homologous recombina 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rxfp1):
     endocrine/exocrine gland  hematopoietic system  integument  reproductive system  respiratory system 
     skeleton 

    Find genes that share phenotypes with RXFP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RXFP1: Rxfp1tm1Lex Rxfp1tm1Aia

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RXFP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RXFP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RXFP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RXFP1

    miRNA
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    miRTarBase miRNAs that target RXFP1:
    hsa-mir-124-3p (MIRT023171), hsa-mir-1 (MIRT024094)

    Block miRNA regulation of human, mouse, rat RXFP1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RXFP1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RXFP1

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RXFP1 (NM_021634)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RXFP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RXFP1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for RXFP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RXFP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RXFP1_HUMAN, Q9HBX9: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytoskeleton1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with RXFP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RXFP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Neuroactive ligand-receptor interaction0.36
    GPCR ligand binding0.71
    Relaxin receptors0.00
    Peptide ligand-binding receptors0.60
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    4GPCRs, Other
    GPCRs, Other
    5G alpha (s) signalling events
    G alpha (s) signalling events


    Find genes that share SuperPaths with RXFP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RXFP1
        Relaxin Pathway
    Activation of PKC through GPCR

    2 BioSystems Pathways for RXFP1
        Myometrial Relaxation and Contraction Pathways
    GPCRs, Other

    2 Reactome Pathways for RXFP1
        Relaxin receptors
    G alpha (s) signalling events


    1 Kegg Pathway  (Kegg details for RXFP1):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Array including RXFP1: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RXFP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RXFP1 (Q9HBX91, 2, 3 ENSP000003032484) via UniProtKB, MINT, STRING, and/or I2D (see all 76)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKAP5P245881, 2, 3, ENSP000003156154EBI-8088969,EBI-703640 MINT-8042760 MINT-8042779 MINT-8041863 MINT-8041836 I2D: score=1 STRING: ENSP00000315615
    PDE4DQ084992, ENSP000003848064MINT-8042744 MINT-8041863 MINT-8041836 MINT-8042714 STRING: ENSP00000384806
    ARRB2P321212, ENSP000002692604MINT-8042744 MINT-8041863 MINT-8041836 MINT-8042714 STRING: ENSP00000269260
    PRKACAP176122, ENSP000003095914MINT-8042744 MINT-8041863 MINT-8041836 MINT-8042714 STRING: ENSP00000309591
    RLN1P048083, ENSP000002238624I2D: score=1 STRING: ENSP00000223862
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway IEA--
    GO:0007567parturition IEA--
    GO:0030154cell differentiation IEA--
    GO:0030198extracellular matrix organization IEA--

    Find genes that share ontologies with RXFP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RXFP1

    1 HMDB Compound for RXFP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    10 IUPHAR Ligands for RXFP1 (RXFP1 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    H2 relaxin
    AgonistFull agonist9.4 - 10.215649866 12506116
    [33P]H2 relaxin
    AgonistFull agonist9.3 - 9.715649866 12506116
    relaxin
    AgonistFull agonist9.415649866
    relaxin
    AgonistFull agonist9.115649866
    europium-labelled H2 relaxin
    AgonistFull agonist919343240
    H1 relaxin
    AgonistFull agonist8.816411781
    H3 relaxin
    AgonistFull agonist7.5 - 815649866 12506116
    relaxin
    AgonistFull agonist7.315649866
    B-R13/17K H2 relaxin
    AntagonistAntagonist6.720043231
    LGR7-truncate
    AntagonistAntagonist6.716963451

    3 Novoseek inferred chemical compound relationships for RXFP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 23.3 1 15956719 (1)
    tyrosine 0 1 15160837 (1)
    estrogen 0 3 19416165 (2), 19416214 (1)



    Find genes that share compounds with RXFP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RXFP1 gene (7 alternative transcripts): 
    NM_001253727.1  NM_001253728.1  NM_001253729.1  NM_001253730.1  NM_001253732.1  NM_001253733.1  NM_021634.3  

    Unigene Cluster for RXFP1:

    Relaxin/insulin-like family peptide receptor 1
    Hs.591686  [show with all ESTs]
    Unigene Representative Sequence: NR_045579
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000460056 ENST00000472969 ENST00000307765(uc010iqk.3 uc011cja.2 uc010iqo.3 uc011cjb.2 uc011cjc.2 uc011cjd.2 uc010iql.3 uc003ipz.3 uc011cje.2 uc010iqm.3 uc011cjf.2 uc010iqn.3)
    ENST00000342048 ENST00000471616(uc010iqj.2) ENST00000343542 ENST00000470033
    ENST00000484785 ENST00000423548 ENST00000448688
    miRNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat RXFP1

    Additional mRNA sequence: 

    AB208943.1 AF190500.1 AK122647.1 AK294694.1 AK295040.1 AK300379.1 AK307889.1 AK312470.1 
    AY899848.1 AY899849.1 AY899850.1 BC112142.1 BC113617.1 BC143556.1 BC143557.1 BC143558.1 
    BC143559.1 BX647975.1 BX647980.1 BX647985.1 NR_045579.1 NR_045580.1 NR_045581.1 NR_045582.1 
    NR_045583.1 NR_045584.1 

    7 DOTS entries:

    DT.97837447  DT.121224972  DT.121224977  DT.97810276  DT.70104005  DT.121224971  DT.92415592 

    Selected AceView cDNA sequences (see all 30):

    AA495745 BX647980 AF190500 AI089319 AI375172 CB216867 CN843659 NM_021634 
    BX089223 CA443652 BM955900 AL709185 BX642361 AL708455 BX647985 AA626188 
    BX647975 AI805323 AL709239 BQ228832 AL708752 AI682875 AA495807 AK122647 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RXFP1 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c
    SP1:                    -                                         -                                                           -                                 
    SP2:                    -                             -           -                                                           -                                 
    SP3:        -     -     -                             -           -                                                           -                                 
    SP4:                    -                             -                                                                                                         
    SP5:                    -           -                 -           -                                                           -                                 


    ECgene alternative splicing isoforms for RXFP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RXFP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAAAAATA
    RXFP1 Expression
    About this image


    RXFP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
    RXFP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RXFP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591686

    UniProtKB/Swiss-Prot: RXFP1_HUMAN, Q9HBX9
    Tissue specificity: Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and
    heart. Not detected in spleen

        Pathway & Disease-focused RT2 Profiler PCR Array including RXFP1: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RXFP1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rxfp11 , 5 relaxin/insulin-like family peptide receptor 11, 5 85.73(n)1
    85.07(a)1
      3 (34.94 cM)5
    3814891  NM_212452.11  NP_997617.11 
     796416115 
    chicken
    (Gallus gallus)
    Aves RXFP11 relaxin/insulin-like family peptide receptor 1 76.1(n)
    77.38(a)
      422415  XM_420385.3  XP_420385.2 
    lizard
    (Anolis carolinensis)
    Reptilia RXFP16
    relaxin/insulin-like family peptide receptor 1
    71(a)
    1 ↔ 1
    5(128385437-128432631)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.181852 Transcribed sequence with weak similarity to protein more 74.13(n)    AL955885.2 
    zebrafish
    (Danio rerio)
    Actinopterygii rxfp11 relaxin/insulin-like family peptide receptor 1 64.52(n)
    64.57(a)
      100498669  NM_001190934.1  NP_001177863.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG344111 CG34411 44.11(n)
    33.99(a)
      5740505  NM_001103496.2  NP_001096966.2 


    ENSEMBL Gene Tree for RXFP1 (if available)
    TreeFam Gene Tree for RXFP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RXFP1 gene
    LHCGR2  LGR52  FSHR2  LGR62  RXFP22  TSHR2  LGR42  
    4 SIMAP similar genes for RXFP1 using alignment to 4 protein entries:     RXFP1_HUMAN (see all proteins):
    LGR7    RXFP2    LRIG3    LRRC4

    Find genes that share paralogs with RXFP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RXFP1 (see all 2460)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs339592601,2
    C,F--155198545(+) AAAAT-/AAAAATATATATAT/AAAATATATATA/
    T
    /TATATAT/TATATATAT/TATATATATA
    TATAT
    27 -- int1 cds12NA 4
    rs285879881,2
    C--155213048(+) ATGGCC/TATATA 13 -- int12Minor allele frequency- T:0.00WA NA 4
    rs100192511,2
    C,F--155232592(+) cttttG/Tttttt 13 -- int1 trp31Minor allele frequency- T:0.50WA 2
    rs715874611,2
    C--155241144(+) CCAATAA/-AGTCT 13 -- int11Minor allele frequency- -:0.50NA 2
    rs1819073541,2
    --159233477(+) AATGAC/GAAAAC 13 -- us2k10--------
    rs105449061,2
    C--159233533(+) GTAAA-/AATAATAA 20 -- us2k1 cds10--------
    rs358672431,2
    C--159233555(+) TAATA-/ATACCTAA 13 -- us2k11Minor allele frequency- ATA:0.00NA 2
    rs14554541,2
    C,F,A,H--159233588(+) TTGCTG/ACAATG 13 -- us2k127Minor allele frequency- A:0.30NS EA NA WA CSA 2766
    rs1466850461,2
    --159233732(+) TACAAC/TGTAAA 13 -- us2k10--------
    rs1402998481,2
    --159233781(+) TAGAAA/GCAGTA 13 -- us2k10--------

    HapMap Linkage Disequilibrium report for RXFP1 (159236463 - 159486463 bp, first 250kb of RXFP1)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RXFP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2669435CNV Deletion23128226
    esv2728610CNV Deletion23290073
    nsv830124CNV Gain17160897
    nsv880895CNV Gain21882294

    3 Site Specific Mutation Identification with PCR Assays for RXFP1:
    Cosmic IdAA Change
    131327p.S609C
    141879p.S269F
    131328p.S609N
    SeqTarget long-range PCR primers for resequencing RXFP1
    DNA2.0 Custom Variant and Variant Library Synthesis for RXFP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606654    OMIM disorders: --

    2 diseases for RXFP1:    
    About MalaCards
    placenta accreta    endometriosis


    Find genes that share disorders with RXFP1           About GenesLikeMe

    2 Novoseek inferred disease relationships for RXFP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 0 1 15956727 (1)
    tumors 0 1 15956727 (1)

    Genetic Association Database (GAD): RXFP1
    Human Genome Epidemiology (HuGE) Navigator: RXFP1 (3 documents)

    Export disorders for RXFP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RXFP1 gene, integrated from 10 sources (see all 116):
    (articles sorted by number of sources associating them with RXFP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2. (PubMed id 12506116)1, 2, 9 Sudo S.... Hsueh A.J.W. (J. Biol. Chem. 2003)
    2. Identification of the N-linked glycosylation sites of the human relaxin receptor and effect of glycosylation on receptor function. (PubMed id 18533687)1, 2, 9 Yan Y....Bathgate R.A. (Biochemistry 2008)
    3. Receptors for relaxin family peptides. (PubMed id 15956688)1, 3, 9 Bathgate R.A....Summers R.J. (Ann. N. Y. Acad. Sci. 2005)
    4. The NMR solution structure of the relaxin (RXFP1) receptor lipoprotein receptor class A module and identification of key residues in the N-terminal region of the module that mediate receptor activation. (PubMed id 17148455)1, 2, 9 Hopkins E.J.... Gooley P.R. (J. Biol. Chem. 2007)
    5. International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides. (PubMed id 16507880)1, 3 Bathgate R.A....Summers R.J. (Pharmacol. Rev. 2006)
    6. Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity. (PubMed id 16051677)1, 2 Muda M.... Bathgate R.A.D. (Mol. Hum. Reprod. 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Relaxin signalling links tyrosine phosphorylation to phosphodiesterase and adenylyl cyclase activity. (PubMed id 11517286)1, 2 Bartsch O.... Ivell R. (Mol. Hum. Reprod. 2001)
    9. The three subfamilies of leucine-rich repeat-containing G protein- coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7. (PubMed id 10935549)1, 2 Hsu S.Y.... Hsueh A.J.W. (Mol. Endocrinol. 2000)
    10. Characterization of relaxin receptor (RXFP1) desensitization and internalization in primary human decidual cells and RXFP1-transfected HEK293 cells. (PubMed id 19116340)1, 9 Kern A. and Bryant-Greenwood G.D. (Endocrinology 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 59350 HGNC: 19718 AceView: LGR7 Ensembl:ENSG00000171509 euGenes: HUgn59350
    ECgene: RXFP1 Kegg: 59350 H-InvDB: RXFP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RXFP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RXFP1 gene:
    Search GeneIP for patents involving RXFP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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