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Aliases for RWDD4 Gene

Aliases for RWDD4 Gene

  • RWD Domain Containing 4 2 3
  • Family With Sequence Similarity 28, Member A 2 3
  • RWD Domain Containing 4A 2 3
  • FAM28A 3 4
  • RWDD4A 3 4
  • RWD Domain-Containing Protein 4A 3
  • Protein FAM28A 4

External Ids for RWDD4 Gene

Previous HGNC Symbols for RWDD4 Gene

  • FAM28A
  • RWDD4A

Previous GeneCards Identifiers for RWDD4 Gene

  • GC04M184561

Summaries for RWDD4 Gene

GeneCards Summary for RWDD4 Gene

RWDD4 (RWD Domain Containing 4) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RWDD4 Gene

Genomics for RWDD4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RWDD4 Gene

183,639,635 bp from pter
183,659,225 bp from pter
19,591 bases
Minus strand

Genomic View for RWDD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RWDD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RWDD4 Gene

No data available for Regulatory Elements for RWDD4 Gene

Proteins for RWDD4 Gene

  • Protein details for RWDD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RWD domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • B2RDE9
    • B4DDP2
    • Q75LA9
    • Q8WVW2

    Protein attributes for RWDD4 Gene

    188 amino acids
    Molecular mass:
    21251 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ96848.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for RWDD4 Gene


neXtProt entry for RWDD4 Gene

Proteomics data for RWDD4 Gene at MOPED

Post-translational modifications for RWDD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RWDD4 Gene

Domains & Families for RWDD4 Gene

Protein Domains for RWDD4 Gene

Suggested Antigen Peptide Sequences for RWDD4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RWD domain.
  • Contains 1 RWD domain.
genes like me logo Genes that share domains with RWDD4: view

No data available for Gene Families for RWDD4 Gene

Function for RWDD4 Gene

Gene Ontology (GO) - Molecular Function for RWDD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with RWDD4: view
genes like me logo Genes that share phenotypes with RWDD4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RWDD4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RWDD4 Gene

Localization for RWDD4 Gene

Subcellular locations from

Jensen Localization Image for RWDD4 Gene COMPARTMENTS Subcellular localization image for RWDD4 gene
Compartment Confidence
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RWDD4 Gene

Pathways & Interactions for RWDD4 Gene

SuperPathways for RWDD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RWDD4 Gene


No data available for Pathways by source and SIGNOR curated interactions for RWDD4 Gene

Drugs & Compounds for RWDD4 Gene

No Compound Related Data Available

Transcripts for RWDD4 Gene

Unigene Clusters for RWDD4 Gene

RWD domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RWDD4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RWDD4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1: - - -
SP2: -
SP3: -

Relevant External Links for RWDD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RWDD4 Gene

mRNA expression in normal human tissues for RWDD4 Gene

Protein differential expression in normal tissues from HIPED for RWDD4 Gene

This gene is overexpressed in Platelet (23.2), Heart (15.9), and Skin (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RWDD4 Gene

SOURCE GeneReport for Unigene cluster for RWDD4 Gene Hs.133337

genes like me logo Genes that share expression patterns with RWDD4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RWDD4 Gene

Orthologs for RWDD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for RWDD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RWDD4 35
  • 89.54 (n)
  • 95.21 (a)
  • 95 (a)
(Canis familiaris)
Mammalia RWDD4 35
  • 90.78 (n)
  • 94.68 (a)
RWDD4 36
  • 95 (a)
(Mus musculus)
Mammalia Rwdd4a 35
  • 85.64 (n)
  • 90.96 (a)
Rwdd4a 16
Rwdd4a 36
  • 91 (a)
(Pan troglodytes)
Mammalia RWDD4 35
  • 99.29 (n)
  • 100 (a)
RWDD4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rwdd4 35
  • 87.23 (n)
  • 92.02 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 94 (a)
-- 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia RWDD4 36
  • 89 (a)
(Gallus gallus)
Aves RWDD4 35
  • 79.03 (n)
  • 84.83 (a)
RWDD4 36
  • 85 (a)
(Anolis carolinensis)
Reptilia RWDD4 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rwdd4 35
  • 70.39 (n)
  • 75 (a)
Str.10704 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1973 35
(Danio rerio)
Actinopterygii rwdd 35
  • 66.86 (n)
  • 66.48 (a)
rwdd 36
  • 65 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010019 35
  • 52.56 (n)
  • 46.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10343 35
  • 54.58 (n)
  • 50 (a)
CG10343 36
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.487 36
  • 47 (a)
Species with no ortholog for RWDD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RWDD4 Gene

Gene Tree for RWDD4 (if available)
Gene Tree for RWDD4 (if available)

Paralogs for RWDD4 Gene Pseudogenes for RWDD4 Gene

genes like me logo Genes that share paralogs with RWDD4: view

No data available for Paralogs for RWDD4 Gene

Variants for RWDD4 Gene

Sequence variations from dbSNP and Humsavar for RWDD4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_024928 -

Structural Variations from Database of Genomic Variants (DGV) for RWDD4 Gene

Variant ID Type Subtype PubMed ID
nsv830165 CNV Loss 17160897
nsv881675 CNV Gain 21882294
dgv5850n71 CNV Gain 21882294
esv2728874 CNV Deletion 23290073
esv2728875 CNV Deletion 23290073

Variation tolerance for RWDD4 Gene

Residual Variation Intolerance Score: 38.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.19; 75.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RWDD4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RWDD4 Gene

Disorders for RWDD4 Gene

Relevant External Links for RWDD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RWDD4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RWDD4 Gene

Publications for RWDD4 Gene

  1. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 67
  2. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 67
  3. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 67
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67
  5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 67

Products for RWDD4 Gene

Sources for RWDD4 Gene

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