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Aliases for RWDD4 Gene

Aliases for RWDD4 Gene

  • RWD Domain Containing 4 2 3 5
  • Family With Sequence Similarity 28, Member A 2 3
  • RWD Domain Containing 4A 2 3
  • FAM28A 3 4
  • RWDD4A 3 4
  • RWD Domain-Containing Protein 4A 3
  • RWD Domain-Containing Protein 4 3
  • Protein FAM28A 4

External Ids for RWDD4 Gene

Previous HGNC Symbols for RWDD4 Gene

  • FAM28A
  • RWDD4A

Previous GeneCards Identifiers for RWDD4 Gene

  • GC04M184561

Summaries for RWDD4 Gene

GeneCards Summary for RWDD4 Gene

RWDD4 (RWD Domain Containing 4) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RWDD4 Gene

Genomics for RWDD4 Gene

Regulatory Elements for RWDD4 Gene

Enhancers for RWDD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F183634 0.5 Ensembl ENCODE 20 +22.8 22823 3.2 CTCF FOXA3 BHLHE40 RAD21 ZNF121 JUND ZFHX2 FOS ZNF600 EGR2 RWDD4 TRAPPC11 RNU6-1053P RNU6-479P LOC105377580
GH04F183638 0.8 ENCODE 20 +20.4 20411 1.3 ZNF121 ZBTB33 RWDD4 TRAPPC11 RNU6-1053P RNU6-479P LOC105377580
GH04F183625 0.6 ENCODE 16 +33.0 32997 0.8 TFAP4 HNF4G RWDD4 TRAPPC11 ING2 LOC389247 RNU6-1053P RNU6-479P LOC105377580
GH04F183617 1.1 Ensembl ENCODE 15.6 +40.0 39953 3.8 MLX ARID4B ZNF48 YY1 GATA2 SP5 JUNB MXD4 MIER2 PPARG RWDD4 RNU6-479P LOC105377580
GH04F183468 1.2 FANTOM5 Ensembl ENCODE 11.7 +189.5 189513 3.0 SOX13 ZNF211 SAP130 CEBPG ZNF316 NFE2 MAFK SOX5 GATAD2A TEAD1 CDKN2AIP RWDD4 TRAPPC11 ING2 VTI1BP2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RWDD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for RWDD4 Gene

183,639,635 bp from pter
183,659,225 bp from pter
19,591 bases
Minus strand

Genomic View for RWDD4 Gene

Genes around RWDD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RWDD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RWDD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RWDD4 Gene

Proteins for RWDD4 Gene

  • Protein details for RWDD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RWD domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • B2RDE9
    • B4DDP2
    • Q75LA9
    • Q8WVW2

    Protein attributes for RWDD4 Gene

    188 amino acids
    Molecular mass:
    21251 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ96848.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for RWDD4 Gene


neXtProt entry for RWDD4 Gene

Post-translational modifications for RWDD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RWDD4 Gene

Domains & Families for RWDD4 Gene

Protein Domains for RWDD4 Gene

Suggested Antigen Peptide Sequences for RWDD4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RWD domain.
  • Contains 1 RWD domain.
genes like me logo Genes that share domains with RWDD4: view

No data available for Gene Families for RWDD4 Gene

Function for RWDD4 Gene

genes like me logo Genes that share phenotypes with RWDD4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RWDD4 Gene

Localization for RWDD4 Gene

Subcellular locations from

Jensen Localization Image for RWDD4 Gene COMPARTMENTS Subcellular localization image for RWDD4 gene
Compartment Confidence
cytoskeleton 3
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RWDD4 Gene

Pathways & Interactions for RWDD4 Gene

SuperPathways for RWDD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RWDD4 Gene


No data available for Pathways by source and SIGNOR curated interactions for RWDD4 Gene

Transcripts for RWDD4 Gene

Unigene Clusters for RWDD4 Gene

RWD domain containing 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RWDD4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1: - - -
SP2: -
SP3: -

Relevant External Links for RWDD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RWDD4 Gene

mRNA expression in normal human tissues for RWDD4 Gene

Protein differential expression in normal tissues from HIPED for RWDD4 Gene

This gene is overexpressed in Platelet (23.2), Heart (15.9), and Skin (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RWDD4 Gene

NURSA nuclear receptor signaling pathways regulating expression of RWDD4 Gene:


SOURCE GeneReport for Unigene cluster for RWDD4 Gene:

genes like me logo Genes that share expression patterns with RWDD4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RWDD4 Gene

Orthologs for RWDD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for RWDD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RWDD4 34 35
  • 99.29 (n)
(Bos Taurus)
Mammalia RWDD4A 35
  • 95 (a)
RWDD4 34
  • 89.54 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 94 (a)
-- 35
  • 86 (a)
(Canis familiaris)
Mammalia RWDD4 34 35
  • 90.78 (n)
(Ornithorhynchus anatinus)
Mammalia RWDD4 35
  • 89 (a)
(Rattus norvegicus)
Mammalia Rwdd4 34
  • 87.23 (n)
(Mus musculus)
Mammalia Rwdd4a 34 16 35
  • 85.64 (n)
(Gallus gallus)
Aves RWDD4 34 35
  • 79.03 (n)
(Anolis carolinensis)
Reptilia RWDD4 35
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rwdd4 34
  • 70.39 (n)
Str.10704 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.1973 34
(Danio rerio)
Actinopterygii rwdd 34 35
  • 66.86 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10343 34 35
  • 54.58 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010019 34
  • 52.56 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.487 35
  • 47 (a)
Species where no ortholog for RWDD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RWDD4 Gene

Gene Tree for RWDD4 (if available)
Gene Tree for RWDD4 (if available)

Paralogs for RWDD4 Gene Pseudogenes for RWDD4 Gene

genes like me logo Genes that share paralogs with RWDD4: view

No data available for Paralogs for RWDD4 Gene

Variants for RWDD4 Gene

Sequence variations from dbSNP and Humsavar for RWDD4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10004167 -- 183,657,256(+) CAAAA(A/C)AAAAC intron-variant
rs10015804 -- 183,649,562(+) GCTTA(G/T)CGATG reference, missense
rs10026546 -- 183,657,068(+) AGAAA(C/T)AGTGT intron-variant
rs10026712 -- 183,657,281(+) CAAGC(C/T)GGATT intron-variant, upstream-variant-2KB
rs10033002 -- 183,652,226(+) CAATC(A/G)TATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RWDD4 Gene

Variant ID Type Subtype PubMed ID
esv2728874 CNV deletion 23290073
esv2728875 CNV deletion 23290073
esv3603444 CNV loss 21293372
esv3603445 CNV gain 21293372
nsv1025333 CNV gain 25217958
nsv1030766 CNV gain 25217958
nsv830165 CNV loss 17160897

Variation tolerance for RWDD4 Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.19; 75.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RWDD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RWDD4 Gene

Disorders for RWDD4 Gene

Relevant External Links for RWDD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RWDD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RWDD4 Gene

Publications for RWDD4 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64

Products for RWDD4 Gene

Sources for RWDD4 Gene

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