RWDD4 Gene
protein-coding GIFtS: 43
GCID: GC04M184561
|
|
RWD domain containing 4(Previous names: family with sequence similarity 28, member A, RWD domain...)
(Previous symbols: FAM28A, RWDD4A)
| |
Aliases
for RWDD4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RWD Domain Containing 41 2 | | MGC101981 | | FAM28A1 2 3 | | RWD Domain-Containing Protein 42 | | RWDD4A1 2 3 | | RWD Domain-Containing Protein 4A2 | | Family With Sequence Similarity 28, Member A1 2 | | Protein FAM28A3 | | RWD Domain Containing 4A1 2 | | |
Export aliases for RWDD4 gene to outside databases |
Summaries
for RWDD4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RWDD4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for RWDD4
Other transcription factors
Search SABiosciences Chromatin IP Primers for RWDD4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RWDD4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q35.1 Ensembl cytogenetic band: 4q35.1 HGNC cytogenetic band: 4q35.1RWDD4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M184561: view genomic region
(about GC identifiers)
Start:
|
184,560,788 bp from pter |
End:
|
184,580,378 bp from pter |
Size:
|
19,591 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 39,930,177-39,932,740 |
|
Proteins
for RWDD4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RWDD4_HUMAN, Q6NW29 (See
protein sequence)Recommended Name: RWD domain-containing protein 4 Size: 188 amino acids; 21251 Da
Sequence caution: Sequence=AAQ96848.1; Type=Erroneous gene model prediction;
Secondary accessions: B2RDE9 Q75LA9 Q8WVW2Explore the universe of human proteins at neXtProt for RWDD4: NX_Q6NW29
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6NW29
RWDD4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689895.2
ENSEMBL proteins: ENSP00000388920 ENSP00000426329 ENSP00000427164 ENSP00000423598 ENSP00000420945 ENSP00000422970 ENSP00000332177
Human Recombinant Protein Products for RWDD4:
RWDD4 Antibody Products:
Assay Products for RWDD4: |
Protein
Domains /
Families
for RWDD4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RWDD4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6NW29ProtoNet protein and cluster: Q6NW29 2 Blocks protein families: IPB000608 Ubiquitin-conjugating enzymes IPB006575 RWD
UniProtKB/Swiss-Prot: RWDD4_HUMAN, Q6NW29Similarity: Contains 1 RWD domain |
Function
for RWDD4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD4 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RWDD4 (NM_152682) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RWDD4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RWDD4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RWDD4 |
|
Pathways & Interactions
for RWDD4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RWDD4
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for RWDD4 (Q6NW292, 3 ENSP000003889204) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for RWDD4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RWDD4
Search CenterWatch for drugs/clinical trials and news about RWDD4
|
Transcripts
for RWDD4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RWDD4 gene: NM_152682.2 Unigene Cluster for RWDD4: RWD domain containing 4 Hs.133337 [show with all ESTs]Unigene Representative Sequence: NM_1526827 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000326397(uc021xvb.1) ENST00000510968 ENST00000510702 ENST00000512740
ENST00000514322(uc011ckl.1) ENST00000506467 ENST00000327570(uc003ivt.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD4 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RWDD4 (NM_152682) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RWDD4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RWDD4 |
Additional cDNA sequence: AK021702.1 AK293274.1 AK315515.1 BC017472.1 BC067752.1 BC107432.1 13 DOTS entries: DT.453562 DT.100777253 DT.101965830 DT.306793 DT.92434153 DT.121094033 DT.121256900 DT.121256905 DT.121256887 DT.40132190 DT.97820216 DT.434001 DT.92434152 24/148 AceView cDNA sequences (see all 148): AA456561 AI583529 BU634301 AA235962 CD723379 AI244242 CB068498 BM762156 BM745990 CD724234 AI963182 BM765728 AI539101 AI478798 AI424225 AI521757 AW965087 AA343918 AA832031 AA721024 AA806032 BQ009186 BU619414 CD724089
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for RWDD4 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 |
|---|
|
| SP1: | | | | | | | - | | | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RWDD4
|
Expression
for RWDD4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RWDD4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAATGAACT
About this image
See RWDD4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RWDD4
SOURCE GeneReport for Unigene cluster: Hs.133337
SABiosciences Custom PCR Arrays for RWDD4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RWDD4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RWDD4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RWDD4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RWDD4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RWDD4 |
Orthologs
for RWDD4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RWDD4 gene from 5/20 species (see all 20) About this table
ENSEMBL Gene Tree for RWDD4 (if available)
TreeFam Gene Tree for RWDD4 (if available) |
Paralogs
for RWDD4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RWDD4 gene
RWDD4 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for RWDD4
PGOHUM00000232667 PGOHUM00000233515
|
Genomic Variants
for RWDD4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RWDD4 (184560788 - 184580378 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RWDD4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RWDD4 |
|
Disorders
/ Diseases
for RWDD4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for RWDD4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RWDD4 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with RWDD4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
|
External Searches for RWDD4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RWDD4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RWDD4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RWDD4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RWDD4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RWDD4 gene:
Search GeneIP for patents involving RWDD4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RWDD4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RWDD4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RWDD4 | | | OriGene Protein Over-expression Lysate for RWDD4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RWDD4 | | OriGene 3'-UTR Clone for RWDD4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RWDD4 | | OriGene Custom Protein Services for RWDD4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RWDD4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RWDD4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RWDD4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RWDD4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RWDD4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RWDD4 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for RWDD4 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | RWDD4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RWDD4 |
|  |  |  |  | | | | ThermoFisher Antibodies for RWDD4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RWDD4 |
| |  | |
|
|
|
