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Aliases for RWDD3 Gene

Aliases for RWDD3 Gene

  • RWD Domain Containing 3 2 3 5
  • RWD Domain-Containing Sumoylation Enhancer 3 4
  • RSUME 3 4
  • RWD-Containing Sumoylation Enhancer 3

External Ids for RWDD3 Gene

Previous GeneCards Identifiers for RWDD3 Gene

  • GC01P095090
  • GC01P095411
  • GC01P095699
  • GC01P093821

Summaries for RWDD3 Gene

GeneCards Summary for RWDD3 Gene

RWDD3 (RWD Domain Containing 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for RWDD3 Gene

  • Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Isoform 1 and isoform 2 negatively regulate the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Isoform 2 promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no effect on ubiquitination.

Gene Wiki entry for RWDD3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RWDD3 Gene

Genomics for RWDD3 Gene

Regulatory Elements for RWDD3 Gene

Promoters for RWDD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RWDD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RWDD3 Gene

Chromosome:
1
Start:
95,234,155 bp from pter
End:
95,247,225 bp from pter
Size:
13,071 bases
Orientation:
Plus strand

Genomic View for RWDD3 Gene

Genes around RWDD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RWDD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RWDD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RWDD3 Gene

Proteins for RWDD3 Gene

  • Protein details for RWDD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3V2-RWDD3_HUMAN
    Recommended name:
    RWD domain-containing protein 3
    Protein Accession:
    Q9Y3V2
    Secondary Accessions:
    • A6NP44
    • A8K9F0
    • C9J9L7
    • C9JI45
    • Q08AJ7
    • Q6FID3
    • Q9BX35

    Protein attributes for RWDD3 Gene

    Size:
    267 amino acids
    Molecular mass:
    30543 Da
    Quaternary structure:
    • Isoform 1 and isoform 2 interact with UBE2I/UBC9 (PubMed:17956732, PubMed:23469069, PubMed:25918163). Isoform 1 shows a greater interaction with NFKBIA and HIF1A as compared to isoform 2 (PubMed:17956732, PubMed:23469069). Isoform 2 interacts with NCOA2 and NR3C1 (PubMed:23508108).

    Three dimensional structures from OCA and Proteopedia for RWDD3 Gene

    Alternative splice isoforms for RWDD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RWDD3 Gene

Proteomics data for RWDD3 Gene at MOPED

Post-translational modifications for RWDD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RWDD3 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for RWDD3

No data available for DME Specific Peptides for RWDD3 Gene

Domains & Families for RWDD3 Gene

Protein Domains for RWDD3 Gene

Suggested Antigen Peptide Sequences for RWDD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y3V2

UniProtKB/Swiss-Prot:

RWDD3_HUMAN :
  • The RWD domain is required for the sumoylation enhancement activity.
Domain:
  • The RWD domain is required for the sumoylation enhancement activity.
  • Contains 1 RWD domain.
genes like me logo Genes that share domains with RWDD3: view

No data available for Gene Families for RWDD3 Gene

Function for RWDD3 Gene

Molecular function for RWDD3 Gene

UniProtKB/Swiss-Prot Function:
Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Isoform 1 and isoform 2 negatively regulate the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Isoform 2 promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no effect on ubiquitination.
UniProtKB/Swiss-Prot Induction:
Induced by hypoxia and heat shock.
genes like me logo Genes that share phenotypes with RWDD3: view

Animal Models for RWDD3 Gene

MGI Knock Outs for RWDD3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RWDD3 Gene

Localization for RWDD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RWDD3 Gene

Nucleus. Cytoplasm. Note=Colocalizes with UBC9/UBE2I in nuclear spots. {ECO:0000269 PubMed:17956732}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RWDD3 Gene COMPARTMENTS Subcellular localization image for RWDD3 gene
Compartment Confidence
nucleus 4
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for RWDD3 Gene

Pathways & Interactions for RWDD3 Gene

SuperPathways for RWDD3 Gene

No Data Available

SIGNOR curated interactions for RWDD3 Gene

Activates:

Gene Ontology (GO) - Biological Process for RWDD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 23469069
genes like me logo Genes that share ontologies with RWDD3: view

No data available for Pathways by source for RWDD3 Gene

Drugs & Compounds for RWDD3 Gene

No Compound Related Data Available

Transcripts for RWDD3 Gene

Unigene Clusters for RWDD3 Gene

RWD domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RWDD3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1:
SP2: - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6: - - - - - -
SP7: - - - - -
SP8:
SP9: - -
SP10: - -

Relevant External Links for RWDD3 Gene

GeneLoc Exon Structure for
RWDD3
ECgene alternative splicing isoforms for
RWDD3

Expression for RWDD3 Gene

mRNA expression in normal human tissues for RWDD3 Gene

Protein differential expression in normal tissues from HIPED for RWDD3 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RWDD3 Gene



SOURCE GeneReport for Unigene cluster for RWDD3 Gene Hs.709591

mRNA Expression by UniProt/SwissProt for RWDD3 Gene

Q9Y3V2-RWDD3_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are expressed in glioma tumors (at protein level). Expressed in a wide number of tissues with highest expression in cerebellum, pituitary, heart, kidney, liver, stomach, pancreas, prostate and spleen. Low levels in thalamus, spinal cord, esophagus, thymus, lung and peripheral blood leukocytes. A higher level expression seen in pituitary tumors as compared to the pituitary gland.
genes like me logo Genes that share expression patterns with RWDD3: view

Protein tissue co-expression partners for RWDD3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RWDD3 Gene

Orthologs for RWDD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RWDD3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RWDD3 35
  • 88.14 (n)
  • 83.9 (a)
RWDD3 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RWDD3 35
  • 91.18 (n)
  • 88.02 (a)
RWDD3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rwdd3 35
  • 84.14 (n)
  • 78.65 (a)
Rwdd3 16
Rwdd3 36
  • 62 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RWDD3 35
  • 99.25 (n)
  • 98.5 (a)
RWDD3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rwdd3 35
  • 84.39 (n)
  • 80.15 (a)
oppossum
(Monodelphis domestica)
Mammalia RWDD3 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RWDD3 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves RWDD3 35
  • 76.19 (n)
  • 69.55 (a)
RWDD3 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RWDD3 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rwdd3 35
  • 65.53 (n)
  • 56.82 (a)
Str.17439 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
rwdd3 35
  • 54.69 (n)
  • 48.05 (a)
Species with no ortholog for RWDD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RWDD3 Gene

ENSEMBL:
Gene Tree for RWDD3 (if available)
TreeFam:
Gene Tree for RWDD3 (if available)

Paralogs for RWDD3 Gene

No data available for Paralogs for RWDD3 Gene

Variants for RWDD3 Gene

Sequence variations from dbSNP and Humsavar for RWDD3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_024346 -
VAR_034420 -
rs259357 -- 95,245,922(-) GTATT(A/C)TTTCT intron-variant
rs592097 -- 95,246,902(+) AATAG(A/C/G/T)AGTGT nc-transcript-variant, utr-variant-3-prime
rs1062155 -- 95,245,667(+) AGGAA(C/T)CTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RWDD3 Gene

Variant ID Type Subtype PubMed ID
nsv830636 CNV Loss 17160897
nsv483022 CNV Gain 15286789
nsv823620 CNV Gain 20364138

Variation tolerance for RWDD3 Gene

Residual Variation Intolerance Score: 41.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RWDD3 Gene

HapMap Linkage Disequilibrium report
RWDD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RWDD3 Gene

Disorders for RWDD3 Gene

Relevant External Links for RWDD3

Genetic Association Database (GAD)
RWDD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RWDD3

No disorders were found for RWDD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RWDD3 Gene

Publications for RWDD3 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. RSUME inhibits VHL and regulates its tumor suppressor function. (PMID: 25500545) Gerez J. … Arzt E. (Oncogene 2015) 3
  3. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu J.H. … Mozaffarian D. (Circ Cardiovasc Genet 2013) 3
  4. RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity. (PMID: 23508108) Druker J. … Arzt E. (Mol. Cell. Biol. 2013) 3
  5. In silico structural and functional characterization of the RSUME splice variants. (PMID: 23469069) Gerez J. … Arzt E. (PLoS ONE 2013) 3

Products for RWDD3 Gene

Sources for RWDD3 Gene

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