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Aliases for RWDD3 Gene

Aliases for RWDD3 Gene

  • RWD Domain Containing 3 2 3 5
  • RWD Domain-Containing Sumoylation Enhancer 3 4
  • RSUME 3 4
  • RWD-Containing Sumoylation Enhancer 3
  • RWD Domain-Containing Protein 3 3

External Ids for RWDD3 Gene

Previous GeneCards Identifiers for RWDD3 Gene

  • GC01P095090
  • GC01P095411
  • GC01P095699
  • GC01P093821

Summaries for RWDD3 Gene

GeneCards Summary for RWDD3 Gene

RWDD3 (RWD Domain Containing 3) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and SUMOylation.

UniProtKB/Swiss-Prot for RWDD3 Gene

  • Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Isoform 1 and isoform 2 negatively regulate the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Isoform 2 promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no effect on ubiquitination.

Gene Wiki entry for RWDD3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RWDD3 Gene

Genomics for RWDD3 Gene

Regulatory Elements for RWDD3 Gene

Enhancers for RWDD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F095071 0.2 ENCODE 19.7 -161.5 -161484 2.3 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 RWDD3 ENSG00000231992 LOC101928118 LOC729970 LOC102723661 ALG14 GC01M095065
GH01F095082 1.1 VISTA Ensembl ENCODE 19.5 -148.6 -148551 5.2 ATF1 PKNOX1 ARNT ARID4B ZNF121 GATA2 ZNF143 FOS NCOA1 REST RWDD3 ENSG00000231992 LOC101928098 LOC101928118 ALG14 LOC729970 GC01M095084 TMEM56
GH01F095139 0.5 FANTOM5 15.1 -94.8 -94793 0.2 SMARCA4 REST RWDD3 TMEM56-RWDD3 TMEM56 ENSG00000206679 GC01M095126 LOC101928118
GH01F094862 1.2 FANTOM5 Ensembl ENCODE 14.2 -369.2 -369188 5.8 SAP130 JUN ZNF384 RAD21 TEAD3 RBAK RCOR1 FOS TCF7L2 CHD2 RWDD3 CNN3 LOC729970 LOC101928098 SLC44A3 LOC101928118 LINC01057 GC01P094917
GH01F095197 0.9 Ensembl ENCODE 10.6 -36.0 -36041 1.2 OSR2 JUND SCRT2 FEZF1 ZNF600 ZIC2 ENSG00000231992 TMEM56 LOC101928118 RWDD3 ENSG00000206679 GC01M095126
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RWDD3 on UCSC Golden Path with GeneCards custom track

Promoters for RWDD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000078658 -155 2401 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143

Genomic Location for RWDD3 Gene

Chromosome:
1
Start:
95,234,155 bp from pter
End:
95,247,225 bp from pter
Size:
13,071 bases
Orientation:
Plus strand

Genomic View for RWDD3 Gene

Genes around RWDD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RWDD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RWDD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RWDD3 Gene

Proteins for RWDD3 Gene

  • Protein details for RWDD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3V2-RWDD3_HUMAN
    Recommended name:
    RWD domain-containing protein 3
    Protein Accession:
    Q9Y3V2
    Secondary Accessions:
    • A6NP44
    • A8K9F0
    • C9J9L7
    • C9JI45
    • Q08AJ7
    • Q6FID3
    • Q9BX35

    Protein attributes for RWDD3 Gene

    Size:
    267 amino acids
    Molecular mass:
    30543 Da
    Quaternary structure:
    • Isoform 1 and isoform 2 interact with UBE2I/UBC9 (PubMed:17956732, PubMed:23469069, PubMed:25918163). Isoform 1 shows a greater interaction with NFKBIA and HIF1A as compared to isoform 2 (PubMed:17956732, PubMed:23469069). Isoform 2 interacts with NCOA2 and NR3C1 (PubMed:23508108).

    Three dimensional structures from OCA and Proteopedia for RWDD3 Gene

    Alternative splice isoforms for RWDD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RWDD3 Gene

Post-translational modifications for RWDD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RWDD3 Gene

No data available for DME Specific Peptides for RWDD3 Gene

Domains & Families for RWDD3 Gene

Protein Domains for RWDD3 Gene

Suggested Antigen Peptide Sequences for RWDD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y3V2

UniProtKB/Swiss-Prot:

RWDD3_HUMAN :
  • The RWD domain is required for the sumoylation enhancement activity.
Domain:
  • The RWD domain is required for the sumoylation enhancement activity.
  • Contains 1 RWD domain.
genes like me logo Genes that share domains with RWDD3: view

No data available for Gene Families for RWDD3 Gene

Function for RWDD3 Gene

Molecular function for RWDD3 Gene

UniProtKB/Swiss-Prot Function:
Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Isoform 1 and isoform 2 negatively regulate the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Isoform 2 promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no effect on ubiquitination.
UniProtKB/Swiss-Prot Induction:
Induced by hypoxia and heat shock.

Gene Ontology (GO) - Molecular Function for RWDD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17956732
genes like me logo Genes that share ontologies with RWDD3: view
genes like me logo Genes that share phenotypes with RWDD3: view

Animal Models for RWDD3 Gene

MGI Knock Outs for RWDD3:

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RWDD3 Gene

Localization for RWDD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RWDD3 Gene

Nucleus. Cytoplasm. Note=Colocalizes with UBC9/UBE2I in nuclear spots. {ECO:0000269 PubMed:17956732}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RWDD3 Gene COMPARTMENTS Subcellular localization image for RWDD3 gene
Compartment Confidence
nucleus 4
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RWDD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RWDD3: view

Pathways & Interactions for RWDD3 Gene

genes like me logo Genes that share pathways with RWDD3: view

SIGNOR curated interactions for RWDD3 Gene

Activates:

Gene Ontology (GO) - Biological Process for RWDD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 23469069
GO:0033235 positive regulation of protein sumoylation IDA 23469069
GO:1902073 positive regulation of hypoxia-inducible factor-1alpha signaling pathway IDA 23469069
genes like me logo Genes that share ontologies with RWDD3: view

Transcripts for RWDD3 Gene

Unigene Clusters for RWDD3 Gene

RWD domain containing 3:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RWDD3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1:
SP2: - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6: - - - - - -
SP7: - - - - -
SP8:
SP9: - -
SP10: - -

Relevant External Links for RWDD3 Gene

GeneLoc Exon Structure for
RWDD3
ECgene alternative splicing isoforms for
RWDD3

Expression for RWDD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RWDD3 Gene

Protein differential expression in normal tissues from HIPED for RWDD3 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RWDD3 Gene



Protein tissue co-expression partners for RWDD3 Gene

NURSA nuclear receptor signaling pathways regulating expression of RWDD3 Gene:

RWDD3

SOURCE GeneReport for Unigene cluster for RWDD3 Gene:

Hs.709591

mRNA Expression by UniProt/SwissProt for RWDD3 Gene:

Q9Y3V2-RWDD3_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are expressed in glioma tumors (at protein level). Expressed in a wide number of tissues with highest expression in cerebellum, pituitary, heart, kidney, liver, stomach, pancreas, prostate and spleen. Low levels in thalamus, spinal cord, esophagus, thymus, lung and peripheral blood leukocytes. A higher level expression seen in pituitary tumors as compared to the pituitary gland.
genes like me logo Genes that share expression patterns with RWDD3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RWDD3 Gene

Orthologs for RWDD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RWDD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RWDD3 34 35
  • 99.25 (n)
dog
(Canis familiaris)
Mammalia RWDD3 34 35
  • 91.18 (n)
cow
(Bos Taurus)
Mammalia RWDD3 34 35
  • 88.14 (n)
rat
(Rattus norvegicus)
Mammalia Rwdd3 34
  • 84.39 (n)
mouse
(Mus musculus)
Mammalia Rwdd3 34 16 35
  • 84.14 (n)
oppossum
(Monodelphis domestica)
Mammalia RWDD3 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RWDD3 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves RWDD3 34 35
  • 76.19 (n)
lizard
(Anolis carolinensis)
Reptilia RWDD3 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rwdd3 34
  • 65.53 (n)
Str.17439 34
zebrafish
(Danio rerio)
Actinopterygii rwdd3 34
  • 54.69 (n)
-- 34
Species where no ortholog for RWDD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RWDD3 Gene

ENSEMBL:
Gene Tree for RWDD3 (if available)
TreeFam:
Gene Tree for RWDD3 (if available)

Paralogs for RWDD3 Gene

No data available for Paralogs for RWDD3 Gene

Variants for RWDD3 Gene

Sequence variations from dbSNP and Humsavar for RWDD3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1062076 -- 95,244,773(+) GTTTT(A/G)TAACA intron-variant, utr-variant-3-prime
rs1062155 -- 95,245,667(+) AGGAA(C/T)CTCTT intron-variant
rs1062156 -- 95,245,670(+) AACCT(C/T)TTGTT intron-variant
rs1062157 -- 95,245,673(+) CTCTT(G/T)TTTTA intron-variant
rs10874908 -- 95,238,595(+) TGTAT(C/G)TTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RWDD3 Gene

Variant ID Type Subtype PubMed ID
nsv823620 CNV gain 20364138
nsv830636 CNV loss 17160897

Variation tolerance for RWDD3 Gene

Residual Variation Intolerance Score: 41.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RWDD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RWDD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RWDD3 Gene

Disorders for RWDD3 Gene

Relevant External Links for RWDD3

Genetic Association Database (GAD)
RWDD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RWDD3

No disorders were found for RWDD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RWDD3 Gene

Publications for RWDD3 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  2. In silico structural and functional characterization of the RSUME splice variants. (PMID: 23469069) Gerez J. … Arzt E. (PLoS ONE 2013) 3 4 64
  3. RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity. (PMID: 23508108) Druker J. … Arzt E. (Mol. Cell. Biol. 2013) 3 4 64
  4. RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells. (PMID: 22009797) Shan B. … Renner U. (Endocr. Relat. Cancer 2012) 3 4 64
  5. RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. (PMID: 17956732) Carbia-Nagashima A. … Arzt E. (Cell 2007) 3 4 64

Products for RWDD3 Gene

Sources for RWDD3 Gene

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