RWDD2B Gene
protein-coding GIFtS: 46
GCID: GC21M030376
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RWD domain containing 2B(Previous name: chromosome 21 open reading frame 6 )
(Previous symbol: C21orf6)
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Aliases
for RWDD2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RWD Domain Containing 2B1 2 | | C21orf61 2 3 | | GL0111 | | Chromosome 21 Open Reading Frame 61 | | RWD Domain-Containing Protein 2B2 |
Export aliases for RWDD2B gene to outside databasesPrevious GC identifers: GC21M029300 GC21M015782 |
Summaries
for RWDD2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for RWDD2B
|
Genomic Views
for RWDD2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000021.8 NC_018932.1 NT_011512.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RWDD2B gene promoter:
c-Fos AP-1 MEF-2 GATA-1 Evi-1 MEF-2A FOXO4 Chx10 c-Jun aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RWDD2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RWDD2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 21q22.11 Ensembl cytogenetic band: 21q21.3 HGNC cytogenetic band: 21q22.11RWDD2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 21 GeneLoc Exon Structure GeneLoc location for GC21M030376: view genomic region
(about GC identifiers)
Start:
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30,376,705 bp from pter |
End:
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30,391,699 bp from pter |
Size:
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14,995 bases |
Orientation:
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minus strand |
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Proteins
for RWDD2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RWD2B_HUMAN, P57060 (See
protein sequence)Recommended Name: RWD domain-containing protein 2B Size: 319 amino acids; 36332 Da
1 PDB 3D structure from  and Proteopedia  for RWDD2B:2DAX (3D)
Explore the universe of human proteins at neXtProt for RWDD2B: NX_P57060
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P57060
RWDD2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_058636.1
ENSEMBL proteins: ENSP00000418693
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
RWDD2B for ontologies About GeneDecksing
RWDD2B Antibody Products:
Assay Products for RWDD2B: |
Protein
Domains /
Families
for RWDD2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RWDD2B for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P57060ProtoNet protein and cluster: P57060 2 Blocks protein families: IPB006575 RWD IPB010541 Protein of unknown function DUF1115
UniProtKB/Swiss-Prot: RWD2B_HUMAN, P57060Similarity: Contains 1 RWD domain |
Function
for RWDD2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD2B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RWDD2B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
RWDD2B for ontologies About GeneDecksing
|
Pathways & Interactions
for RWDD2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RWDD2B
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/6 Interacting proteins for RWDD2B (P570602, 3 ENSP000004186934) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
RWDD2B for ontologies About GeneDecksing
|
Drugs & Compounds
for RWDD2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RWDD2B
Search CenterWatch for drugs/clinical trials and news about RWDD2B / RWD2B
|
Transcripts
for RWDD2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RWDD2B gene: NM_016940.2 Unigene Cluster for RWDD2B: RWD domain containing 2B Hs.744239 [show with all ESTs]Unigene Representative Sequence: AK0000567 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000493196(uc002yms.3) ENST00000486719 ENST00000286777 ENST00000472184
ENST00000466746 ENST00000481411 ENST00000471269
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD2B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RWDD2B (NM_016940) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RWDD2B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RWDD2B |
Additional cDNA sequence: AF212232.1 AK000056.1 AK223357.1 AL355726.1 AL355727.1 BC012546.1 BC017912.1 Y19009.1 11 DOTS entries: DT.315143 DT.100778347 DT.121132637 DT.87016362 DT.121132621 DT.121132620 DT.95094986 DT.92426102 DT.99980746 DT.101982806 DT.100723769 24/143 AceView cDNA sequences (see all 143): CR607703 BE017992 BM127951 BC017912 CR610226 BI771230 CF264970 BP378473 CR592518 AW264762 AA316030 BG679157 BG574271 AA435676 AF212232 BE301503 CB178393 BP354098 CB132391 BU689778 BM806250 AA680073 AA534637 CA425694
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for RWDD2B (see all 13) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b | · | 8c |
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| SP1: | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | - | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RWDD2B
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Expression
for RWDD2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RWDD2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTGAAAGCA
About this image
See RWDD2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RWDD2B
SOURCE GeneReport for Unigene cluster: Hs.744239
UniProtKB/Swiss-Prot: RWD2B_HUMAN, P57060Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for RWDD2B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RWDD2B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RWDD2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RWDD2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RWDD2B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RWDD2B |
Orthologs
for RWDD2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RWDD2B gene from 3/15 species (see all 15) About this table
ENSEMBL Gene Tree for RWDD2B (if available)
TreeFam Gene Tree for RWDD2B (if available) |
Paralogs
for RWDD2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RWDD2B gene
- RWDD2A2
1 SIMAP similar gene for RWDD2B using alignment to 1 protein entry: RWD2B_HUMAN:RWDD2A
RWDD2B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for RWDD2B
PGOHUM00000246141
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Genomic Variants
for RWDD2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 21 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RWDD2B (30376705 - 30391699 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RWDD2B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RWDD2B |
|
Disorders
/ Diseases
for RWDD2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RWDD2B for disorders About GeneDecksing
1  disease for RWDD2B: About MalaCardsmalaria
Export disorders for RWDD2B gene to outside databases
|
Publications
for RWDD2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RWDD2B gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with RWDD2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of a novel gene, C21orf6, mapping to a critical region of chromosome 21q22.1 involved in the monosomy 21 phenotype and of its murine ortholog, orf5. (PubMed id 10729227)1, 2, 3 Orti R.... Delabar J.-M. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Functional analysis and identification of cis-regulat ory elements of human chromosome 21 gene promoters. (PubMed id 20494980)1 Warnatz H.J....Yaspo M.L. (2010)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
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External Searches for RWDD2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RWDD2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RWDD2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RWDD2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RWDD2B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RWDD2B gene:
Search GeneIP for patents involving RWDD2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RWDD2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RWDD2B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RWDD2B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RWDD2B | | | OriGene Protein Over-expression Lysate for RWDD2B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RWDD2B | | OriGene 3'-UTR Clone for RWDD2B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD2B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD2B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RWDD2B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RWDD2B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RWDD2B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RWDD2B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RWDD2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RWDD2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RWDD2B |
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 | | | RWDD2B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RWDD2B |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RWDD2B |
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