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Aliases for RWDD2B Gene

Aliases for RWDD2B Gene

  • RWD Domain Containing 2B 2 3
  • C21orf6 3 4
  • Chromosome 21 Open Reading Frame 6 2
  • RWD Domain-Containing Protein 2B 3
  • GL011 3

External Ids for RWDD2B Gene

Previous HGNC Symbols for RWDD2B Gene

  • C21orf6

Previous GeneCards Identifiers for RWDD2B Gene

  • GC21M029300
  • GC21M030376
  • GC21M015782

Summaries for RWDD2B Gene

GeneCards Summary for RWDD2B Gene

RWDD2B (RWD Domain Containing 2B) is a Protein Coding gene. An important paralog of this gene is RWDD2A.

Gene Wiki entry for RWDD2B Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RWDD2B Gene

Genomics for RWDD2B Gene

Regulatory Elements for RWDD2B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RWDD2B Gene

29,004,384 bp from pter
29,019,378 bp from pter
14,995 bases
Minus strand

Genomic View for RWDD2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RWDD2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RWDD2B Gene

Proteins for RWDD2B Gene

  • Protein details for RWDD2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RWD domain-containing protein 2B
    Protein Accession:
    Secondary Accessions:

    Protein attributes for RWDD2B Gene

    319 amino acids
    Molecular mass:
    36332 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RWDD2B Gene

neXtProt entry for RWDD2B Gene

Proteomics data for RWDD2B Gene at MOPED

Post-translational modifications for RWDD2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RWDD2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RWDD2B Gene

Domains for RWDD2B Gene

Protein Domains for RWDD2B Gene

Suggested Antigen Peptide Sequences for RWDD2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P57060
  • Contains 1 RWD domain.
genes like me logo Genes that share domains with RWDD2B: view

No data available for Gene Families for RWDD2B Gene

Function for RWDD2B Gene

Gene Ontology (GO) - Molecular Function for RWDD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with RWDD2B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RWDD2B Gene

Localization for RWDD2B Gene

Subcellular locations from

Jensen Localization Image for RWDD2B Gene COMPARTMENTS Subcellular localization image for RWDD2B gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for RWDD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with RWDD2B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RWDD2B Gene

Pathways for RWDD2B Gene

SuperPathways for RWDD2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RWDD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with RWDD2B: view

No data available for Pathways by source for RWDD2B Gene

Transcripts for RWDD2B Gene

Unigene Clusters for RWDD2B Gene

RWD domain containing 2B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RWDD2B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RWDD2B Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - - - - - -
SP6: - - - -
SP7: - - - - - -
SP8: - - - - - - -
SP9: - - -
SP10: - - - - -
SP11: - -
SP12: - - - - - - - - - - - - - -
SP13: - - - -

Relevant External Links for RWDD2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RWDD2B Gene

mRNA expression in normal human tissues for RWDD2B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RWDD2B Gene

SOURCE GeneReport for Unigene cluster for RWDD2B Gene Hs.713123

mRNA Expression by UniProt/SwissProt for RWDD2B Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with RWDD2B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RWDD2B Gene

Orthologs for RWDD2B Gene

This gene was present in the common ancestor of animals.

Orthologs for RWDD2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RWDD2B 35
  • 99.58 (n)
  • 99.06 (a)
  • 99 (a)
(Bos Taurus)
Mammalia RWDD2B 35
  • 87.82 (n)
  • 85.17 (a)
  • 80 (a)
(Canis familiaris)
Mammalia RWDD2B 35
  • 89.85 (n)
  • 89.62 (a)
  • 90 (a)
(Mus musculus)
Mammalia Rwdd2b 35
  • 84.83 (n)
  • 82.07 (a)
Rwdd2b 16
Rwdd2b 36
  • 82 (a)
(Monodelphis domestica)
Mammalia RWDD2B 36
  • 71 (a)
(Rattus norvegicus)
Mammalia Rwdd2b 35
  • 85.4 (n)
  • 85.86 (a)
(Gallus gallus)
Aves RWDD2B 35
  • 69.66 (n)
  • 64.48 (a)
  • 58 (a)
(Anolis carolinensis)
Reptilia RWDD2B 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rwdd2b 35
  • 60.44 (n)
  • 58.13 (a)
(Danio rerio)
Actinopterygii rwdd2b 35
  • 60.52 (n)
  • 53.55 (a)
rwdd2b 36
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30338 36
  • 27 (a)
Species with no ortholog for RWDD2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RWDD2B Gene

Gene Tree for RWDD2B (if available)
Gene Tree for RWDD2B (if available)

Paralogs for RWDD2B Gene

Paralogs for RWDD2B Gene

Selected SIMAP similar genes for RWDD2B Gene using alignment to 1 proteins: Pseudogenes for RWDD2B Gene

genes like me logo Genes that share paralogs with RWDD2B: view

Variants for RWDD2B Gene

Sequence variations from dbSNP and Humsavar for RWDD2B Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs11170 -- 29,005,769(+) CAAAA(C/T)TGGTT utr-variant-3-prime
rs878797 -- 29,018,988(-) GCGGC(C/T)GCGTG intron-variant
rs1047036 -- 29,008,582(-) GCAGG(C/T)GGAGG reference, missense
rs1047075 -- 29,005,871(-) ACGAC(A/G)GAAGG utr-variant-3-prime
rs1984012 -- 29,020,151(+) GCCCA(C/T)TAACC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RWDD2B Gene

Variant ID Type Subtype PubMed ID
nsv513570 CNV Insertion 21212237
esv1501473 CNV Insertion 17803354
esv1730794 CNV Insertion 17803354

Relevant External Links for RWDD2B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RWDD2B Gene

Disorders for RWDD2B Gene

No disorders were found for RWDD2B Gene.

No data available for UniProtKB/Swiss-Prot for RWDD2B Gene

Publications for RWDD2B Gene

  1. Characterization of a novel gene, C21orf6, mapping to a critical region of chromosome 21q22.1 involved in the monosomy 21 phenotype and of its murine ortholog, orf5. (PMID: 10729227) Orti R. … Delabar J.-M. (Genomics 2000) 2 3 4
  2. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for RWDD2B Gene

  • antibodies-online proteins for RWDD2B
  • antibodies-online antibodies for RWDD2B
  • antibodies-online kits for RWDD2B

Sources for RWDD2B Gene

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