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RWDD2A Gene

protein-coding   GIFtS: 39
GCID: GC06P083903

RWD Domain Containing 2A

(Previous name: RWD domain containing 2)
(Previous symbol: RWDD2)
  Search for RWDD2A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RWD Domain Containing 2A1 2
RWDD21 2 3
RWD Domain Containing 21 2
dJ747H23.22
RWD Domain-Containing Protein 2A2

External Ids:    HGNC: 213851   Entrez Gene: 1126112   Ensembl: ENSG000000133927   UniProtKB: Q9UIY33   

Export aliases for RWDD2A gene to outside databases

Previous GC identifers: GC06P083959 GC06P081131


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RWDD2A Gene:
RWDD2A (RWD domain containing 2A) is a protein-coding gene. An important paralog of this gene is RWDD2B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the RWDD2A gene promoter:
         AML1a   MyoD   Pax-2   Pax-2a   POU3F2   YY1   RORalpha1   Sox9   Msx-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RWDD2A promoter sequence
   Search Chromatin IP Primers for RWDD2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RWDD2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14.2   Ensembl cytogenetic band:  6q14.2   HGNC cytogenetic band: 6q15

RWDD2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RWDD2A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P083903:  view genomic region     (about GC identifiers)

Start:
83,903,032 bp from pter      End:
83,908,651 bp from pter
Size:
5,620 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RWD2A_HUMAN, Q9UIY3 (See protein sequence)
Recommended Name: RWD domain-containing protein 2A  
Size: 292 amino acids; 33893 Da
1 PDB 3D structure from and Proteopedia for RWDD2A:
2DAW (3D)    
Secondary accessions: E1P548 Q2M3R3 Q96FH1

Explore the universe of human proteins at neXtProt for RWDD2A: NX_Q9UIY3

Explore proteomics data for RWDD2A at MOPED


See RWDD2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_219479.2  
ENSEMBL proteins: 
 ENSP00000358739   ENSP00000442731  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR016135 UBQ-conjugating_enzyme/RWD
 IPR010541 DUF1115
 IPR006575 RWD-domain
 IPR017359 UCP038021_RWD

Graphical View of Domain Structure for InterPro Entry Q9UIY3

ProtoNet protein and cluster: Q9UIY3

2 Blocks protein domains:
IPB006575 RWD
IPB010541 Protein of unknown function DUF1115


UniProtKB/Swiss-Prot: RWD2A_HUMAN, Q9UIY3
Similarity: Contains 1 RWD domain


Find genes that share domains with RWDD2A           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
Find genes that share ontologies with RWDD2A           About GenesLikeMe


Animal Models:
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SwitchGear 3'UTR luciferase reporter plasmidRWDD2A 3' UTR sequence
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol4
nucleus4
cytoskeleton2
peroxisome1
plasma membrane1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RWDD2A
Interactions:

    Search GeneGlobe Interaction Network for RWDD2A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for RWDD2A (RWD2A)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for RWDD2A gene: 
NM_033411.3  

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000369724(uc003pjx.4 uc011dza.2) ENST00000539997
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SwitchGear 3'UTR luciferase reporter plasmidRWDD2A 3' UTR sequence
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Selected AceView cDNA sequences (see all 84):

AA830733 BQ082336 AI191402 AA677441 BM661789 NM_033411 AW662865 AI955001 
CB215752 BC034826 CD108545 BP370311 AI954970 AA121033 AW197622 BM795449 
BF001563 AW274871 BC010930 AI186780 AA424652 CD655420 BM545340 H49489 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for RWDD2A    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1:                                                
SP2:                    -     -                     
SP3:                    -                           


ECgene alternative splicing isoforms for RWDD2A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RWDD2A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTTTCAGAT
RWDD2A Expression
About this image

RWDD2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RWDD2A Protein Expression
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for RWDD2A gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rwdd2a1 , 5 RWD domain containing 2A1, 5 86.99(n)1
93.15(a)1
  9 (46.58 cM)5
695191  NM_001145969.11  NP_001139441.11 
 865720535 
chicken
(Gallus gallus)
Aves RWDD2A1 RWD domain containing 2A 67.82(n)
60(a)
  421840  XM_419861.4  XP_419861.1 
lizard
(Anolis carolinensis)
Reptilia RWDD2A6
RWD domain containing 2A
65(a)
1 ↔ 1
1(197739427-197742431)
tropical clawed frog
(Xenopus tropicalis)
Amphibia rwdd2a1 RWD domain containing 2A 65.16(n)
63.07(a)
  100127626  NM_001112978.1  NP_001106449.1 
fruit fly
(Drosophila melanogaster)
Insecta CG303381 CG30338 45.56(n)
33.2(a)
  246548  NM_165685.3  NP_724811.1 


ENSEMBL Gene Tree for RWDD2A (if available)
TreeFam Gene Tree for RWDD2A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RWDD2A gene
RWDD2B2  
1 SIMAP similar gene for RWDD2A using alignment to 2 protein entries:     RWD2A_HUMAN (see all proteins):
RWDD2B

Find genes that share paralogs with RWDD2A           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RWDD2A (see all 18)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1480732581,2
C--83905720(+) AGAGCA/GCTGTG 2 H R mis10--------
rs786402611,2
C--83905790(+) GAAAGA/C/TGTGGA 3 R S mis1 syn10--------
rs2010342751,2
--83905821(+) ACCTGC/TGCCTT 2 R C mis10--------
rs1828647831,2
C--83905997(+) AAAGCG/AATTAA 1 -- ut311Minor allele frequency- A:0.00EU 1303
rs22950911,2
C,F,H--83906191(-) ACCTAG/CAGATA 1 -- ut31 ese34Minor allele frequency- C:0.01NS EA 416
rs1398418151,2
--83906537(+) AAGTAG/TCTGGG 1 -- int10--------
rs412715751,2
C,F--83906555(+) GCGTGC/TGCCAC 1 -- int12Minor allele frequency- T:0.25NA WA 4
rs1125798541,2
C,F--83906564(+) ACCACG/ACCCAG 1 -- int11Minor allele frequency- A:0.50WA 2
rs1390771231,2
--83906594(+) TAGAGA/GCAGGG 1 -- int10--------
rs1875866681,2
--83906640(+) AACCTC/TGTGAT 1 -- int10--------

HapMap Linkage Disequilibrium report for RWDD2A (83903032 - 83908651 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for RWDD2A: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing RWDD2A
DNA2.0 Custom Variant and Variant Library Synthesis for RWDD2A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RWDD2A gene integrated from 10 sources:
(articles sorted by number of sources associating them with RWDD2A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  4. Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. (PubMed id 7829101)1 Robertson N.G....Morton C.C. (Genomics 1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 112611 HGNC: 21385 AceView: RWDD2 Ensembl:ENSG00000013392 euGenes: HUgn112611
ECgene: RWDD2A H-InvDB: RWDD2A

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RWDD2A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RWDD2A gene:
Search GeneIP for patents involving RWDD2A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RWDD2A
 SwitchGear 3'UTR luciferase reporter plasmids for RWDD2A
 SwitchGear Promoter luciferase reporter plasmids for RWDD2A
 ThermoFisher Antibody for RWDD2A
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RWDD2A
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RWDD2A
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RWDD2A
 LSBio Antibodies in human, mouse, rat for RWDD2A
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 Search Addgene for plasmids for RWDD2A
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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