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Aliases for RWDD2A Gene

Aliases for RWDD2A Gene

  • RWD Domain Containing 2A 2 3
  • RWD Domain Containing 2 2 3
  • RWDD2 3 4
  • DJ747H23.2 3

External Ids for RWDD2A Gene

Previous HGNC Symbols for RWDD2A Gene

  • RWDD2

Previous GeneCards Identifiers for RWDD2A Gene

  • GC06P083959
  • GC06P081131
  • GC06P083903

Summaries for RWDD2A Gene

GeneCards Summary for RWDD2A Gene

RWDD2A (RWD Domain Containing 2A) is a Protein Coding gene. An important paralog of this gene is RWDD2B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RWDD2A Gene

Genomics for RWDD2A Gene

Regulatory Elements for RWDD2A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RWDD2A Gene

83,193,313 bp from pter
83,198,932 bp from pter
5,620 bases
Plus strand

Genomic View for RWDD2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for RWDD2A Gene

Proteins for RWDD2A Gene

  • Protein details for RWDD2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RWD domain-containing protein 2A
    Protein Accession:
    Secondary Accessions:
    • B4DIQ3
    • E1P548
    • Q2M3R3
    • Q96FH1

    Protein attributes for RWDD2A Gene

    292 amino acids
    Molecular mass:
    33893 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RWDD2A Gene

    Alternative splice isoforms for RWDD2A Gene


neXtProt entry for RWDD2A Gene

Proteomics data for RWDD2A Gene at MOPED

Post-translational modifications for RWDD2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RWDD2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RWDD2A Gene

Domains & Families for RWDD2A Gene

Protein Domains for RWDD2A Gene

Suggested Antigen Peptide Sequences for RWDD2A Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RWD domain.
  • Contains 1 RWD domain.
genes like me logo Genes that share domains with RWDD2A: view

No data available for Gene Families for RWDD2A Gene

Function for RWDD2A Gene

Gene Ontology (GO) - Molecular Function for RWDD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with RWDD2A: view
genes like me logo Genes that share phenotypes with RWDD2A: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RWDD2A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RWDD2A Gene

Localization for RWDD2A Gene

Subcellular locations from

Jensen Localization Image for RWDD2A Gene COMPARTMENTS Subcellular localization image for RWDD2A gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RWDD2A Gene

Pathways & Interactions for RWDD2A Gene

SuperPathways for RWDD2A Gene

No Data Available

Interacting Proteins for RWDD2A Gene

Gene Ontology (GO) - Biological Process for RWDD2A Gene


No data available for Pathways by source and SIGNOR curated interactions for RWDD2A Gene

Drugs & Compounds for RWDD2A Gene

No Compound Related Data Available

Transcripts for RWDD2A Gene

Unigene Clusters for RWDD2A Gene

RWD domain containing 2A:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RWDD2A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RWDD2A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP2: - -
SP3: -

Relevant External Links for RWDD2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RWDD2A Gene

mRNA expression in normal human tissues for RWDD2A Gene

Protein differential expression in normal tissues from HIPED for RWDD2A Gene

This gene is overexpressed in Retina (44.7), Frontal cortex (15.6), and Spinal cord (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for RWDD2A Gene

SOURCE GeneReport for Unigene cluster for RWDD2A Gene Hs.709686

genes like me logo Genes that share expression patterns with RWDD2A: view

Protein tissue co-expression partners for RWDD2A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RWDD2A Gene

Orthologs for RWDD2A Gene

This gene was present in the common ancestor of animals.

Orthologs for RWDD2A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RWDD2A 35
  • 89.84 (n)
  • 95.55 (a)
  • 96 (a)
(Canis familiaris)
Mammalia RWDD2A 35
  • 92.92 (n)
  • 97.95 (a)
  • 98 (a)
(Mus musculus)
Mammalia Rwdd2a 35
  • 86.99 (n)
  • 93.15 (a)
Rwdd2a 16
Rwdd2a 36
  • 93 (a)
(Pan troglodytes)
Mammalia RWDD2A 35
  • 99.89 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Rwdd2a 35
  • 87.33 (n)
  • 93.15 (a)
(Monodelphis domestica)
Mammalia RWDD2A 36
  • 67 (a)
(Gallus gallus)
Aves RWDD2A 35
  • 67.82 (n)
  • 60 (a)
  • 60 (a)
(Anolis carolinensis)
Reptilia RWDD2A 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rwdd2a 35
  • 65.16 (n)
  • 63.07 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011898 35
  • 45.65 (n)
  • 32.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30338 35
  • 45.56 (n)
  • 33.2 (a)
CG30338 36
  • 28 (a)
Species with no ortholog for RWDD2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RWDD2A Gene

Gene Tree for RWDD2A (if available)
Gene Tree for RWDD2A (if available)

Paralogs for RWDD2A Gene

Paralogs for RWDD2A Gene

(1) SIMAP similar genes for RWDD2A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RWDD2A: view

Variants for RWDD2A Gene

Sequence variations from dbSNP and Humsavar for RWDD2A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2295091 -- 83,196,472(-) ACCTA(C/G)AGATA utr-variant-3-prime
rs6902437 -- 83,199,019(+) AGGCC(A/G)GATGA downstream-variant-500B
rs9449587 -- 83,197,968(+) TCCTA(C/G)CCTTG utr-variant-3-prime
rs12190337 -- 83,198,513(+) GTTTG(C/T)ACAGC utr-variant-3-prime
rs16882103 -- 83,198,850(+) CTTAA(A/G)TGGTT utr-variant-3-prime

Variation tolerance for RWDD2A Gene

Residual Variation Intolerance Score: 32.71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RWDD2A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RWDD2A Gene

Disorders for RWDD2A Gene

Relevant External Links for RWDD2A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RWDD2A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RWDD2A Gene

Publications for RWDD2A Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 67
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for RWDD2A Gene

Sources for RWDD2A Gene

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