RWDD2A Gene
protein-coding GIFtS: 41
GCID: GC06P083903
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RWD domain containing 2A(Previous name: RWD domain containing 2 )
(Previous symbol: RWDD2)
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Aliases
for RWDD2A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RWD Domain Containing 2A1 2 | | RWDD21 2 3 | | DJ747H23.21 | | RWD Domain Containing 21 2 | | MGC135231 | | RWD Domain-Containing Protein 2A2 |
Export aliases for RWDD2A gene to outside databasesPrevious GC identifers: GC06P083959 GC06P081131 |
Summaries
for RWDD2A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RWDD2A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007299.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RWDD2A gene promoter:
AML1a MyoD Pax-2 Pax-2a POU3F2 YY1 RORalpha1 Sox9 Msx-1 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for RWDD2A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RWDD2A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q14.2 Ensembl cytogenetic band: 6q14.2 HGNC cytogenetic band: 6q15RWDD2A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P083903: view genomic region
(about GC identifiers)
Start:
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83,903,032 bp from pter |
End:
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83,906,382 bp from pter |
Size:
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3,351 bases |
Orientation:
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plus strand |
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Proteins
for RWDD2A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RWD2A_HUMAN, Q9UIY3 (See
protein sequence)Recommended Name: RWD domain-containing protein 2A Size: 292 amino acids; 33893 Da
1 PDB 3D structure from  and Proteopedia  for RWDD2A:2DAW (3D)
Secondary accessions: E1P548 Q2M3R3 Q96FH1Explore the universe of human proteins at neXtProt for RWDD2A: NX_Q9UIY3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UIY3
RWDD2A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_219479.2
ENSEMBL proteins: ENSP00000358739 ENSP00000442731
Human Recombinant Protein Products:
RWDD2A Antibody Products:
Assay Products for RWDD2A: |
Protein
Domains /
Families
for RWDD2A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RWDD2A for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UIY3ProtoNet protein and cluster: Q9UIY3 2 Blocks protein families: IPB006575 RWD IPB010541 Protein of unknown function DUF1115
UniProtKB/Swiss-Prot: RWD2A_HUMAN, Q9UIY3Similarity: Contains 1 RWD domain |
Function
for RWDD2A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD2A (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD2A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RWDD2A (NM_033411) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RWDD2A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RWDD2A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RWDD2A |
|
Pathways & Interactions
for RWDD2A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RWDD2A
|
Drugs & Compounds
for RWDD2A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RWDD2A
Search CenterWatch for drugs/clinical trials and news about RWDD2A / RWD2A
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Transcripts
for RWDD2A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RWDD2A gene: NM_033411.3 Unigene Cluster for RWDD2A: RWD domain containing 2A Hs.709686 [show with all ESTs]Unigene Representative Sequence: AK2957242 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369724(uc003pjx.4 uc011dza.2) ENST00000539997
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD2A (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD2A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RWDD2A (NM_033411) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RWDD2A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RWDD2A |
Additional cDNA sequence: AK295724.1 AK302978.1 AK309249.1 AK313083.1 BC010930.2 BC104816.1 BC112003.1 7 DOTS entries: DT.411201 DT.95157171 DT.95318830 DT.95157173 DT.121328691 DT.408146 DT.95157172 24/84 AceView cDNA sequences (see all 84): AW197622 AA677441 NM_033411 BQ082336 BP370311 AI954970 AA830733 BC010930 BM795449 AW274871 AA121033 CB215752 BM661789 CD108545 AW662865 AI955001 BC034826 AI191402 BF001563 BG772595 AI150486 AI695704 AW135358 AA424652
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for RWDD2A About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c |
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| SP1: | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for RWDD2A
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Expression
for RWDD2A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RWDD2A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTTCAGAT
About this image
See RWDD2A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RWDD2A
SOURCE GeneReport for Unigene cluster: Hs.709686
SABiosciences Custom PCR Arrays for RWDD2A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RWDD2A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RWDD2A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RWDD2A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RWDD2A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RWDD2A |
Orthologs
for RWDD2A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for RWDD2A gene from 4/16 species (see all 16) About this table
ENSEMBL Gene Tree for RWDD2A (if available)
TreeFam Gene Tree for RWDD2A (if available) |
Paralogs
for RWDD2A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RWDD2A gene
- RWDD2B2
1 SIMAP similar gene for RWDD2A using alignment to 2 protein entries: RWD2A_HUMAN (see all proteins):RWDD2B
RWDD2A for paralogs About GeneDecksing
|
Genomic Variants
for RWDD2A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RWDD2A (83903032 - 83906382 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RWDD2A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RWDD2A |
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Disorders
/ Diseases
for RWDD2A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RWDD2A for disorders About GeneDecksing
1  disease for RWDD2A: About MalaCardsmalaria
Export disorders for RWDD2A gene to outside databases
|
Publications
for RWDD2A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RWDD2A gene integrated from 9 sources:
(articles sorted by number of sources associating them with RWDD2A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. (PubMed id 7829101)1 Robertson N.G....Morton C.C. (1994)
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External Searches for RWDD2A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing RWDD2A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing RWDD2A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RWDD2A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RWDD2A | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for RWDD2A gene:
Search GeneIP for patents involving RWDD2A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RWDD2A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RWDD2A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RWDD2A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RWDD2A | | | OriGene Protein Over-expression Lysate for RWDD2A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RWDD2A | | OriGene 3'-UTR Clone for RWDD2A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD2A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD2A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RWDD2A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for RWDD2A |
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 | | | RWDD2A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RWDD2A |
|  |  |  | | | | ThermoFisher Antibody for RWDD2A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RWDD2A |
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