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Aliases for RWDD1 Gene

Aliases for RWDD1 Gene

  • RWD Domain Containing 1 2 3 5
  • DRG Family-Regulatory Protein 2 3 4
  • CGI-24 3
  • PTD013 3
  • DFRP2 4

External Ids for RWDD1 Gene

Previous GeneCards Identifiers for RWDD1 Gene

  • GC06P116892
  • GC06P116938
  • GC06P116999
  • GC06P114472

Summaries for RWDD1 Gene

GeneCards Summary for RWDD1 Gene

RWDD1 (RWD Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for RWDD1 Gene

  • Protects DRG2 from proteolytic degradation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RWDD1 Gene

Genomics for RWDD1 Gene

Regulatory Elements for RWDD1 Gene

Promoters for RWDD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RWDD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RWDD1 Gene

Chromosome:
6
Start:
116,571,367 bp from pter
End:
116,597,675 bp from pter
Size:
26,309 bases
Orientation:
Plus strand

Genomic View for RWDD1 Gene

Genes around RWDD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RWDD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RWDD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RWDD1 Gene

Proteins for RWDD1 Gene

  • Protein details for RWDD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H446-RWDD1_HUMAN
    Recommended name:
    RWD domain-containing protein 1
    Protein Accession:
    Q9H446
    Secondary Accessions:
    • A8K3W2
    • A8MT24
    • Q9Y313
    • Q9Y6B3

    Protein attributes for RWDD1 Gene

    Size:
    243 amino acids
    Molecular mass:
    27940 Da
    Quaternary structure:
    • Interacts with DRG2. Interacts with androgen receptor (By similarity).

    Three dimensional structures from OCA and Proteopedia for RWDD1 Gene

    Alternative splice isoforms for RWDD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RWDD1 Gene

Proteomics data for RWDD1 Gene at MOPED

Post-translational modifications for RWDD1 Gene

  • Ubiquitination at Lys 157
  • Modification sites at PhosphoSitePlus

Other Protein References for RWDD1 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for RWDD1

No data available for DME Specific Peptides for RWDD1 Gene

Domains & Families for RWDD1 Gene

Protein Domains for RWDD1 Gene

Suggested Antigen Peptide Sequences for RWDD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H446

UniProtKB/Swiss-Prot:

RWDD1_HUMAN :
  • Contains 1 RWD domain.
  • Belongs to the RWDD1/GIR2 family.
Domain:
  • Contains 1 RWD domain.
Family:
  • Belongs to the RWDD1/GIR2 family.
genes like me logo Genes that share domains with RWDD1: view

No data available for Gene Families for RWDD1 Gene

Function for RWDD1 Gene

Molecular function for RWDD1 Gene

UniProtKB/Swiss-Prot Function:
Protects DRG2 from proteolytic degradation.
genes like me logo Genes that share phenotypes with RWDD1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RWDD1 Gene

Localization for RWDD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RWDD1 Gene COMPARTMENTS Subcellular localization image for RWDD1 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RWDD1 Gene

Pathways & Interactions for RWDD1 Gene

SuperPathways for RWDD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RWDD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RWDD1 Gene

Drugs & Compounds for RWDD1 Gene

No Compound Related Data Available

Transcripts for RWDD1 Gene

Unigene Clusters for RWDD1 Gene

RWD domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RWDD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1:
SP2:
SP3: - -

Relevant External Links for RWDD1 Gene

GeneLoc Exon Structure for
RWDD1
ECgene alternative splicing isoforms for
RWDD1

Expression for RWDD1 Gene

mRNA expression in normal human tissues for RWDD1 Gene

Protein differential expression in normal tissues from HIPED for RWDD1 Gene

This gene is overexpressed in Skin (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RWDD1 Gene



SOURCE GeneReport for Unigene cluster for RWDD1 Gene Hs.532164

genes like me logo Genes that share expression patterns with RWDD1: view

Protein tissue co-expression partners for RWDD1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RWDD1 Gene

Orthologs for RWDD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RWDD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RWDD1 35
  • 95.34 (n)
  • 96.71 (a)
RWDD1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RWDD1 35
  • 94.1 (n)
  • 98.77 (a)
RWDD1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rwdd1 35
  • 89.03 (n)
  • 96.3 (a)
Rwdd1 16
Rwdd1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RWDD1 35
  • 99.86 (n)
  • 100 (a)
RWDD1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rwdd1 35
  • 90.12 (n)
  • 97.12 (a)
oppossum
(Monodelphis domestica)
Mammalia RWDD1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RWDD1 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves RWDD1 35
  • 83.33 (n)
  • 88.33 (a)
RWDD1 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RWDD1 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rwdd1 35
  • 72.94 (n)
  • 79.5 (a)
Str.14743 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8141 35
zebrafish
(Danio rerio)
Actinopterygii rwdd1 35
  • 73 (n)
  • 77.65 (a)
rwdd1 36
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003063 35
  • 49.45 (n)
  • 42.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5515 35
  • 49.53 (n)
  • 44.81 (a)
CG5515 36
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_T26E3.4 35
  • 48.86 (n)
  • 36.76 (a)
T26E3.4 36
  • 31 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GIR2 36
  • 26 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G51730 35
  • 48.41 (n)
  • 39.2 (a)
rice
(Oryza sativa)
Liliopsida Os01g0558300 35
  • 53.72 (n)
  • 40.43 (a)
Species with no ortholog for RWDD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RWDD1 Gene

ENSEMBL:
Gene Tree for RWDD1 (if available)
TreeFam:
Gene Tree for RWDD1 (if available)

Paralogs for RWDD1 Gene

Pseudogenes.org Pseudogenes for RWDD1 Gene

genes like me logo Genes that share paralogs with RWDD1: view

No data available for Paralogs for RWDD1 Gene

Variants for RWDD1 Gene

Sequence variations from dbSNP and Humsavar for RWDD1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1033723 -- 116,575,565(+) ATTTT(A/T)GTTAC intron-variant
rs1033724 -- 116,575,748(+) aggga(C/T)acatc intron-variant
rs1321533 -- 116,580,022(+) ATAAA(A/C)GGTAA intron-variant
rs1321534 -- 116,580,477(+) AATCT(A/G)CTATG intron-variant
rs1983721 -- 116,584,324(+) GGGCT(A/G)TAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RWDD1 Gene

Variant ID Type Subtype PubMed ID
nsv523972 CNV Gain 19592680
nsv830783 CNV Gain 17160897
esv268808 CNV Insertion 20981092
esv272181 CNV Insertion 20981092

Variation tolerance for RWDD1 Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RWDD1 Gene

HapMap Linkage Disequilibrium report
RWDD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RWDD1 Gene

Disorders for RWDD1 Gene

Relevant External Links for RWDD1

Genetic Association Database (GAD)
RWDD1
Human Genome Epidemiology (HuGE) Navigator
RWDD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RWDD1

No disorders were found for RWDD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RWDD1 Gene

Publications for RWDD1 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for RWDD1 Gene

Sources for RWDD1 Gene

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