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RWDD1 Gene

protein-coding   GIFtS: 50
GCID: GC06P116892

RWD Domain Containing 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RWD Domain Containing 11 2
DRG Family-Regulatory Protein 22 3
PTD0132
RWD Domain-Containing Protein 12
DFRP23

External Ids:    HGNC: 209931   Entrez Gene: 513892   Ensembl: ENSG000001118327   UniProtKB: Q9H4463   

Export aliases for RWDD1 gene to outside databases

Previous GC identifers: GC06P116938 GC06P116999 GC06P114472


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RWDD1 Gene:
RWDD1 (RWD domain containing 1) is a protein-coding gene. Diseases associated with RWDD1 include cleft lip, and malaria.

UniProtKB/Swiss-Prot: RWDD1_HUMAN, Q9H446
Function: Protects DRG2 from proteolytic degradation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the RWDD1 gene promoter:
         Nkx3-1   Brachyury   FOXD1   Nkx3-1 v1   Nkx2-5   C/EBPalpha   Nkx3-1 v2   AREB6   MZF-1   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRWDD1 promoter sequence
   Search Chromatin IP Primers for RWDD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RWDD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q13-q22.33   Ensembl cytogenetic band:  6q22.1   HGNC cytogenetic band: 6q13-q22.33

RWDD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RWDD1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P116892:  view genomic region     (about GC identifiers)

Start:
116,892,530 bp from pter      End:
116,918,838 bp from pter
Size:
26,309 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RWDD1_HUMAN, Q9H446 (See protein sequence)
Recommended Name: RWD domain-containing protein 1  
Size: 243 amino acids; 27940 Da
Subunit: Interacts with DRG2. Interacts with androgen receptor (By similarity)
1 PDB 3D structure from and Proteopedia for RWDD1:
2EBM (3D)    
Secondary accessions: A8K3W2 A8MT24 Q9Y313 Q9Y6B3
Alternative splicing: 2 isoforms:  Q9H446-1   Q9H446-2   

Explore the universe of human proteins at neXtProt for RWDD1: NX_Q9H446

Explore proteomics data for RWDD1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys157
  • Modification sites at PhosphoSitePlus

  • See RWDD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001007465.1  NP_057036.2  NP_057188.2  

    ENSEMBL proteins: 
     ENSP00000420357   ENSP00000429070   ENSP00000428778   ENSP00000429942   ENSP00000428704  
     ENSP00000376311  

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    Novus Biologicals RWDD1 Lysates
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    Cloud-Clone Corp. Proteins for RWDD1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR006575 RWD-domain

    Graphical View of Domain Structure for InterPro Entry Q9H446

    ProtoNet protein and cluster: Q9H446

    2 Blocks protein domains:
    IPB000608 Ubiquitin-conjugating enzymes
    IPB006575 RWD


    UniProtKB/Swiss-Prot: RWDD1_HUMAN, Q9H446
    Similarity: Belongs to the RWDD1/GIR2 family
    Similarity: Contains 1 RWD domain


    RWDD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RWDD1_HUMAN, Q9H446
    Function: Protects DRG2 from proteolytic degradation (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    RWDD1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RWDD1:
     Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RWDD1
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    miRNA
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    miRTarBase miRNAs that target RWDD1:
    hsa-mir-7-5p (MIRT047771)

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    Search for qRT-PCR Assays for microRNAs that regulate RWDD1
    SwitchGear 3'UTR luciferase reporter plasmidRWDD1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RWDD1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): RWDD1 (NM_015952)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RWDD1
    Interactions:

        Search GeneGlobe Interaction Network for RWDD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for RWDD1 (Q9H4461, 2, 3 ENSP000004203574) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DRG1Q9Y2951, 2, 3, ENSP000003297154EBI-748952,EBI-719554 MINT-67401 I2D: score=6 STRING: ENSP00000329715
    DRG2P550392, 3, ENSP000002257294MINT-67842 I2D: score=5 STRING: ENSP00000225729
    NUDT18Q6ZVK82, 3, ENSP000003078524MINT-67544 I2D: score=5 STRING: ENSP00000307852
    RAC3P607633I2D: score=1 
    GCN1L1ENSP000003006484STRING: ENSP00000300648
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RWDD1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RWDD1 gene (3 alternative transcripts): 
    NM_001007464.2  NM_015952.3  NM_016104.3  

    Unigene Cluster for RWDD1:

    RWD domain containing 1
    Hs.532164  [show with all ESTs]
    Unigene Representative Sequence: AK301089
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466444(uc003pxd.3) ENST00000368590 ENST00000487832 ENST00000517800
    ENST00000518117 ENST00000468204 ENST00000392526(uc003pxb.3 uc003pxc.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RWDD1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RWDD1
    SwitchGear 3'UTR luciferase reporter plasmidRWDD1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RWDD1
    Predesigned siRNA for gene silencing in human, mouse, rat RWDD1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RWDD1 (NM_015952)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RWDD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RWDD1
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RWDD1
      QuantiTect SYBR Green Assays in human, mouse, rat RWDD1
      QuantiFast Probe-based Assays in human, mouse, rat RWDD1

    Additional mRNA sequence: 

    AF092134.1 AF132958.1 AK290727.1 AK301089.1 AY927558.1 BC008693.1 BC012534.1 BC015802.1 

    9 DOTS entries:

    DT.86854671  DT.215262  DT.101983054  DT.95358329  DT.215260  DT.91776425  DT.95082296  DT.95191775 
    DT.75156789 

    Selected AceView cDNA sequences (see all 141):

    BQ019003 AI990780 AA429976 AI540467 CK299234 BM905886 BF445815 AI351214 
    BE779684 AA351489 CF128570 AI281255 AI080045 AI090297 AI696402 AA936210 
    AI963143 AA687141 BU153971 W70016 AI589074 AA180030 AL043237 BP341655 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RWDD1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:                                                                        
    SP2:                                                                        
    SP3:              -     -                                                   


    ECgene alternative splicing isoforms for RWDD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RWDD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACTCCAGT
    RWDD1 Expression
    About this image


    RWDD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    RWDD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RWDD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532164
        Custom PCR Arrays for RWDD1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RWDD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RWDD1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rwdd11 , 5 RWD domain containing 11, 5 89.03(n)1
    96.3(a)1
      10 (18.85 cM)5
    665211  NM_025614.31  NP_079890.11 
     339965555 
    chicken
    (Gallus gallus)
    Aves RWDD11 RWD domain containing 1 83.33(n)
    88.33(a)
      421741  NM_001031075.2  NP_001026246.2 
    lizard
    (Anolis carolinensis)
    Reptilia RWDD16
    RWD domain containing 1
    88(a)
    1 ↔ 1
    1(186178759-186193133)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.81412 Xenopus laevis transcribed sequence with moderate similarity more 80.19(n)    CD302941.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK360785.12   -- 76.16(n)    CK360785.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG55151 CG5515 49.53(n)
    44.81(a)
      42875  NM_001275972.1  NP_001262901.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_T26E3.41 CELE_T26E3.4 48.86(n)
    36.76(a)
      173136  NM_060806.8  NP_493207.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GIR26
    Highly-acidic cytoplasmic RWD domain-containing pr...
    26(a)
    1 ↔ 1
    IV(765706-766503) YDR152W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G517301 AT1G51730 48.41(n)
    39.2(a)
      841598  NM_104051.4  NP_175584.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g05583001 Os01g0558300 53.72(n)
    40.43(a)
      4324673  NM_001049869.1  NP_001043334.1 


    ENSEMBL Gene Tree for RWDD1 (if available)
    TreeFam Gene Tree for RWDD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RWDD1 gene

    RWDD1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for RWDD1
    PGOHUM00000239868 PGOHUM00000246859 PGOHUM00000247192


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RWDD1 (see all 444)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1494724441,2
    --116890641(+) TATGGC/TCAAAA 3 -- us2k10--------
    rs1459696151,2
    C--116890748(+) GTATCA/GAAGTA 3 -- us2k10--------
    rs1148992641,2
    C,F--116890836(+) ATTTTG/TTTAAT 3 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1385465831,2
    --116890837(+) TTTTGC/TTAATG 3 -- us2k10--------
    rs1155393111,2
    F--116890949(+) ATCTCA/CTTTCT 3 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1415112681,2
    --116890988(+) AGGAGA/CAAAAA 3 -- us2k10--------
    rs1836840861,2
    --116891039(+) AAAGAC/TGTAAT 3 -- us2k10--------
    rs1462807791,2
    --116891098(+) CAACAC/GAACTT 3 -- us2k10--------
    rs1484738391,2
    --116891127(+) AGCCAA/GAAATC 3 -- us2k10--------
    rs748450411,2
    F--116891161(+) TTAATG/CCACTA 3 -- us2k11Minor allele frequency- C:0.03NA 120

    HapMap Linkage Disequilibrium report for RWDD1 (116892530 - 116918838 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RWDD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv268808CNV Insertion20981092
    esv272181CNV Insertion20981092
    nsv523972CNV Gain19592680
    nsv830783CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for RWDD1:    
    About MalaCards
    cleft lip    malaria


    RWDD1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RWDD1
    Human Genome Epidemiology (HuGE) Navigator: RWDD1 (1 document)

    Export disorders for RWDD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RWDD1 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with RWDD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    2. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (Genet. Med. 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51389 HGNC: 20993 AceView: RWDD1 Ensembl:ENSG00000111832 euGenes: HUgn51389
    ECgene: RWDD1 H-InvDB: RWDD1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RWDD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RWDD1 gene:
    Search GeneIP for patents involving RWDD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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