RWDD1 Gene
protein-coding GIFtS: 46
GCID: GC06P116938
|
|
RWD domain containing 1
| |
Aliases
for RWDD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RWD Domain Containing 11 2 | | PTD0131 2 | | DRG Family-Regulatory Protein 22 3 | | RWD Domain-Containing Protein 12 | | DFRP23 |
Export aliases for RWDD1 gene to outside databasesPrevious GC identifers: GC06P116892 GC06P116999 GC06P114472 |
Summaries
for RWDD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RWDD1_HUMAN, Q9H446Function: Protects DRG2 from proteolytic degradation (By similarity)
|
Genomic Views
for RWDD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RWDD1 gene promoter:
Nkx3-1 Brachyury FOXD1 Nkx3-1 v1 Nkx2-5 C/EBPalpha Nkx3-1 v2 AREB6 MZF-1 Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for RWDD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RWDD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q13-q22.33 Ensembl cytogenetic band: 6q22.1 HGNC cytogenetic band: 6q13-q22.33RWDD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P116938: view genomic region
(about GC identifiers)
Start:
|
116,892,530 bp from pter |
End:
|
116,918,838 bp from pter |
Size:
|
26,309 bases |
Orientation:
|
plus strand |
|
Proteins
for RWDD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RWDD1_HUMAN, Q9H446 (See
protein sequence)Recommended Name: RWD domain-containing protein 1 Size: 243 amino acids; 27940 Da
Subunit: Interacts with DRG2. Interacts with androgen receptor (By similarity)
1 PDB 3D structure from  and Proteopedia  for RWDD1:2EBM (3D)
Secondary accessions: A8K3W2 A8MT24 Q9Y313 Q9Y6B3Alternative splicing: 2 isoforms: Q9H446-1 Q9H446-2 Explore the universe of human proteins at neXtProt for RWDD1: NX_Q9H446
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H446
RWDD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001007465.1 NP_057036.2 NP_057188.2
ENSEMBL proteins: ENSP00000420357 ENSP00000429070 ENSP00000428778 ENSP00000429942 ENSP00000428704 ENSP00000376311
Human Recombinant Protein Products:
RWDD1 Antibody Products:
Assay Products for RWDD1: |
Protein
Domains /
Families
for RWDD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RWDD1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H446ProtoNet protein and cluster: Q9H446 2 Blocks protein families: IPB000608 Ubiquitin-conjugating enzymes IPB006575 RWD
UniProtKB/Swiss-Prot: RWDD1_HUMAN, Q9H446Similarity: Belongs to the RWDD1/GIR2 familySimilarity: Contains 1 RWD domain |
Function
for RWDD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RWDD1_HUMAN, Q9H446Function: Protects DRG2 from proteolytic degradation (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): RWDD1 (NM_015952) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RWDD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RWDD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RWDD1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
RWDD1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RWDD1:
|
Pathways & Interactions
for RWDD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RWDD1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/10 Interacting proteins for RWDD1 (Q9H4461, 2, 3 ENSP000004203574) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
|
Drugs & Compounds
for RWDD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RWDD1
Search CenterWatch for drugs/clinical trials and news about RWDD1
|
Transcripts
for RWDD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RWDD1 gene (3 alternative transcripts): NM_001007464.1 NM_015952.2 NM_016104.2 Unigene Cluster for RWDD1: RWD domain containing 1 Hs.532164 [show with all ESTs]Unigene Representative Sequence: AK3010897 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000466444(uc003pxd.3) ENST00000368590 ENST00000487832 ENST00000517800
ENST00000518117 ENST00000468204 ENST00000392526(uc003pxb.3 uc003pxc.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): RWDD1 (NM_015952) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RWDD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RWDD1 |
Additional cDNA sequence: AF092134.1 AF132958.1 AK290727.1 AK301089.1 AY927558.1 BC008693.1 BC012534.1 BC015802.1 9 DOTS entries: DT.86854671 DT.215262 DT.101983054 DT.95358329 DT.215260 DT.91776425 DT.95082296 DT.95191775 DT.75156789 24/141 AceView cDNA sequences (see all 141): CK299234 AI963143 BM761228 BM905886 AI090297 AI990780 AW134621 AA829929 AI589074 AL043237 BQ019003 BM714565 AI696402 AA687141 AI080045 AI417770 AA429976 AA487499 BF445815 BC008693 CF128570 BP341655 AI129713 W70016
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for RWDD1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RWDD1
|
Expression
for RWDD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RWDD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTACTCCAGT
About this image
See RWDD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RWDD1
SOURCE GeneReport for Unigene cluster: Hs.532164
SABiosciences Custom PCR Arrays for RWDD1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RWDD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RWDD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RWDD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RWDD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RWDD1 |
Orthologs
for RWDD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RWDD1 gene from 10/33 species (see all 33) About this table
ENSEMBL Gene Tree for RWDD1 (if available)
TreeFam Gene Tree for RWDD1 (if available) |
Paralogs
for RWDD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RWDD1 gene
RWDD1 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for RWDD1
PGOHUM00000239868 PGOHUM00000246859 PGOHUM00000247192
|
Genomic Variants
for RWDD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RWDD1 (116892530 - 116918838 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RWDD1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RWDD1 |
|
Disorders
/ Diseases
for RWDD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RWDD1 for disorders About GeneDecksing
3  diseases for RWDD1: About MalaCardscleft lip/palate cleft lip malaria
Human Genome Epidemiology (HuGE) Navigator: RWDD1 (1 document)
Export disorders for RWDD1 gene to outside databases
|
Publications
for RWDD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RWDD1 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with RWDD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1 Vieira A.R....Marazita M.L. (2008)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
|
External Searches for RWDD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RWDD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RWDD1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RWDD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RWDD1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RWDD1 gene:
Search GeneIP for patents involving RWDD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RWDD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RWDD1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RWDD1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RWDD1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RWDD1 | | OriGene 3'-UTR Clone for RWDD1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RWDD1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RWDD1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RWDD1 | | OriGene Custom Protein Services for RWDD1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RWDD1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RWDD1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RWDD1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RWDD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RWDD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RWDD1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for RWDD1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | RWDD1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RWDD1 |
|  |  |  | | | | Search ThermoFisher Antibodies for RWDD1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RWDD1 |
|
|
|
|
