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Aliases for RWDD1 Gene

Aliases for RWDD1 Gene

  • RWD Domain Containing 1 2 3
  • DRG Family-Regulatory Protein 2 3 4
  • RWD Domain-Containing Protein 1 3
  • CGI-24 3
  • PTD013 3
  • DFRP2 4

External Ids for RWDD1 Gene

Summaries for RWDD1 Gene

GeneCards Summary for RWDD1 Gene

RWDD1 (RWD Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for RWDD1 Gene

  • Protects DRG2 from proteolytic degradation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RWDD1 Gene

Genomics for RWDD1 Gene

Genomic Location for RWDD1 Gene

Start:
116,571,367 bp from pter
End:
116,597,675 bp from pter
Size:
26,309 bases
Orientation:
Plus strand

Genomic View for RWDD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RWDD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RWDD1 Gene

Regulatory Elements for RWDD1 Gene

Proteins for RWDD1 Gene

  • Protein details for RWDD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H446-RWDD1_HUMAN
    Recommended name:
    RWD domain-containing protein 1
    Protein Accession:
    Q9H446
    Secondary Accessions:
    • A8K3W2
    • A8MT24
    • Q9Y313
    • Q9Y6B3

    Protein attributes for RWDD1 Gene

    Size:
    243 amino acids
    Molecular mass:
    27940 Da
    Quaternary structure:
    • Interacts with DRG2. Interacts with androgen receptor (By similarity).

    Three dimensional structures from OCA and Proteopedia for RWDD1 Gene

    Alternative splice isoforms for RWDD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RWDD1 Gene

Proteomics data for RWDD1 Gene at MOPED

Post-translational modifications for RWDD1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys157

Other Protein References for RWDD1 Gene

No data available for DME Specific Peptides for RWDD1 Gene

Domains for RWDD1 Gene

Protein Domains for RWDD1 Gene

UniProtKB/Swiss-Prot:

RWDD1_HUMAN
Domain:
  • Contains 1 RWD domain.:
    • Q9H446
Family:
  • Belongs to the RWDD1/GIR2 family.:
    • Q9H446
genes like me logo Genes that share domains with RWDD1: view

No data available for Gene Families for RWDD1 Gene

Function for RWDD1 Gene

Molecular function for RWDD1 Gene

UniProtKB/Swiss-Prot Function: Protects DRG2 from proteolytic degradation.

Gene Ontology (GO) - Molecular Function for RWDD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with RWDD1: view

Phenotypes for RWDD1 Gene

GenomeRNAi human phenotypes for RWDD1:
genes like me logo Genes that share phenotypes with RWDD1: view

miRNA for RWDD1 Gene

miRTarBase miRNAs that target RWDD1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RWDD1 Gene

Localization for RWDD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RWDD1 Gene COMPARTMENTS Subcellular localization image for RWDD1 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for RWDD1 Gene

Pathways for RWDD1 Gene

SuperPathways for RWDD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RWDD1 Gene

None

No data available for Pathways by source for RWDD1 Gene

Transcripts for RWDD1 Gene

Unigene Clusters for RWDD1 Gene

RWD domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RWDD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1:
SP2:
SP3: - -

Relevant External Links for RWDD1 Gene

GeneLoc Exon Structure for
RWDD1
ECgene alternative splicing isoforms for
RWDD1

Expression for RWDD1 Gene

mRNA expression in normal human tissues for RWDD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RWDD1 Gene

SOURCE GeneReport for Unigene cluster for RWDD1 Gene Hs.532164

genes like me logo Genes that share expressions with RWDD1: view

Orthologs for RWDD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RWDD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RWDD1 36
  • 99.86 (n)
  • 100 (a)
RWDD1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RWDD1 36
  • 95.34 (n)
  • 96.71 (a)
RWDD1 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RWDD1 36
  • 94.1 (n)
  • 98.77 (a)
RWDD1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rwdd1 36
  • 89.03 (n)
  • 96.3 (a)
Rwdd1 16
Rwdd1 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RWDD1 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RWDD1 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rwdd1 36
  • 90.12 (n)
  • 97.12 (a)
chicken
(Gallus gallus)
Aves RWDD1 36
  • 83.33 (n)
  • 88.33 (a)
RWDD1 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RWDD1 37
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8141 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rwdd1 36
  • 72.94 (n)
  • 79.5 (a)
Str.14743 36
zebrafish
(Danio rerio)
Actinopterygii rwdd1 36
  • 73 (n)
  • 77.65 (a)
rwdd1 37
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003063 36
  • 49.45 (n)
  • 42.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5515 36
  • 49.53 (n)
  • 44.81 (a)
CG5515 37
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_T26E3.4 36
  • 48.86 (n)
  • 36.76 (a)
T26E3.4 37
  • 31 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GIR2 37
  • 26 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G51730 36
  • 48.41 (n)
  • 39.2 (a)
rice
(Oryza sativa)
Liliopsida Os01g0558300 36
  • 53.72 (n)
  • 40.43 (a)
Species with no ortholog for RWDD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RWDD1 Gene

ENSEMBL:
Gene Tree for RWDD1 (if available)
TreeFam:
Gene Tree for RWDD1 (if available)

Paralogs for RWDD1 Gene

Pseudogenes.org Pseudogenes for RWDD1 Gene

genes like me logo Genes that share paralogs with RWDD1: view

No data available for Paralogs for RWDD1 Gene

Variants for RWDD1 Gene

Sequence variations from dbSNP and Humsavar for RWDD1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1033723 -- 116,575,565(+) ATTTT(A/T)GTTAC intron-variant
rs1033724 -- 116,575,748(+) aggga(C/T)acatc intron-variant
rs1321533 -- 116,580,022(+) ATAAA(A/C)GGTAA intron-variant
rs1321534 -- 116,580,477(+) AATCT(A/G)CTATG intron-variant
rs1964137 -- 116,593,788(+) aaaat(A/G)caaaa downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RWDD1 Gene

Variant ID Type Subtype PubMed ID
nsv523972 CNV Gain 19592680
nsv830783 CNV Gain 17160897
esv268808 CNV Insertion 20981092
esv272181 CNV Insertion 20981092

Relevant External Links for RWDD1 Gene

HapMap Linkage Disequilibrium report
RWDD1

Disorders for RWDD1 Gene

Relevant External Links for RWDD1

Genetic Association Database (GAD)
RWDD1
Human Genome Epidemiology (HuGE) Navigator
RWDD1
genes like me logo Genes that share disorders with RWDD1: view

No data available for UniProtKB/Swiss-Prot for RWDD1 Gene

Publications for RWDD1 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira A.R. … Marazita M.L. (Genet. Med. 2008) 3 49
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for RWDD1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RWDD1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RWDD1
    • Block miRNA regulation of RWDD1 using miScript Target Protectors

    Sources for RWDD1 Gene

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