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Aliases for RWDD1 Gene

Aliases for RWDD1 Gene

  • RWD Domain Containing 1 2 3 5
  • DRG Family-Regulatory Protein 2 3 4
  • RWD Domain-Containing Protein 1 3
  • CGI-24 3
  • PTD013 3
  • DFRP2 4

External Ids for RWDD1 Gene

Previous GeneCards Identifiers for RWDD1 Gene

  • GC06P116892
  • GC06P116938
  • GC06P116999
  • GC06P114472

Summaries for RWDD1 Gene

GeneCards Summary for RWDD1 Gene

RWDD1 (RWD Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for RWDD1 Gene

  • Protects DRG2 from proteolytic degradation.

Additional gene information for RWDD1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RWDD1 Gene

Genomics for RWDD1 Gene

Regulatory Elements for RWDD1 Gene

Enhancers for RWDD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H116570 1.2 ENCODE 29.1 +0.5 473 3 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 RWDD1 ENSG00000240050 RSPH4A CBX3P9 ENSG00000237021
GH06H116461 1.3 FANTOM5 Ensembl ENCODE 7.7 -107.7 -107713 4.5 MXI1 BACH1 MAX BMI1 E2F1 CTBP1 ZNF316 POLR2A SCRT2 RUNX3 CALHM6 DSE ENSG00000234117 TRAPPC3L RWDD1 TSPYL1 ZUFSP ENSG00000244158
GH06H116679 1.4 FANTOM5 ENCODE 6.1 +110.2 110219 3.2 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 DSE TPI1P3 ENSG00000240050 RWDD1 ENSG00000237021 CALHM6 KPNA5 ZUFSP TSPYL1 TSPYL4
GH06H116665 1.3 FANTOM5 ENCODE 6.3 +96.1 96135 3.8 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZUFSP CALHM5 KPNA5 RWDD1 DSE GC06P116597
GH06H116409 1.6 FANTOM5 Ensembl ENCODE dbSUPER 5.1 -160.3 -160303 3.1 ZSCAN4 BATF ATF7 ETV6 RUNX3 CREM IKZF2 ELF1 ZNF217 PRDM6 CALHM6 DSE CBX3P9 KRT18P22 ENSG00000244158 CALHM4 ENSG00000234117 RWDD1 PIR34878 PIR33476
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RWDD1 on UCSC Golden Path with GeneCards custom track

Promoters for RWDD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000201695 233 2401 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B

Genomic Locations for RWDD1 Gene

Genomic Locations for RWDD1 Gene
chr6:116,571,367-116,597,675
(GRCh38/hg38)
Size:
26,309 bases
Orientation:
Plus strand
chr6:116,892,530-116,918,838
(GRCh37/hg19)

Genomic View for RWDD1 Gene

Genes around RWDD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RWDD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RWDD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RWDD1 Gene

Proteins for RWDD1 Gene

  • Protein details for RWDD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H446-RWDD1_HUMAN
    Recommended name:
    RWD domain-containing protein 1
    Protein Accession:
    Q9H446
    Secondary Accessions:
    • A8K3W2
    • A8MT24
    • Q9Y313
    • Q9Y6B3

    Protein attributes for RWDD1 Gene

    Size:
    243 amino acids
    Molecular mass:
    27940 Da
    Quaternary structure:
    • Interacts with DRG2. Interacts with androgen receptor (By similarity).

    Three dimensional structures from OCA and Proteopedia for RWDD1 Gene

    Alternative splice isoforms for RWDD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RWDD1 Gene

Post-translational modifications for RWDD1 Gene

  • Ubiquitination at Lys157
  • Modification sites at PhosphoSitePlus

Other Protein References for RWDD1 Gene

No data available for DME Specific Peptides for RWDD1 Gene

Domains & Families for RWDD1 Gene

Gene Families for RWDD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RWDD1 Gene

Suggested Antigen Peptide Sequences for RWDD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H446

UniProtKB/Swiss-Prot:

RWDD1_HUMAN :
  • Belongs to the RWDD1/GIR2 family.
Family:
  • Belongs to the RWDD1/GIR2 family.
genes like me logo Genes that share domains with RWDD1: view

Function for RWDD1 Gene

Molecular function for RWDD1 Gene

UniProtKB/Swiss-Prot Function:
Protects DRG2 from proteolytic degradation.

Gene Ontology (GO) - Molecular Function for RWDD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with RWDD1: view
genes like me logo Genes that share phenotypes with RWDD1: view

Animal Models for RWDD1 Gene

MGI Knock Outs for RWDD1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RWDD1 Gene

Localization for RWDD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RWDD1 gene
Compartment Confidence
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for RWDD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005844 polysome IBA --
genes like me logo Genes that share ontologies with RWDD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RWDD1 Gene

Pathways & Interactions for RWDD1 Gene

SuperPathways for RWDD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RWDD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002181 cytoplasmic translation IBA --
GO:0007569 cell aging IEA --
GO:0030521 androgen receptor signaling pathway IEA --
GO:0034599 cellular response to oxidative stress IEA --
GO:0071394 cellular response to testosterone stimulus IEA --
genes like me logo Genes that share ontologies with RWDD1: view

No data available for Pathways by source and SIGNOR curated interactions for RWDD1 Gene

Drugs & Compounds for RWDD1 Gene

No Compound Related Data Available

Transcripts for RWDD1 Gene

Unigene Clusters for RWDD1 Gene

RWD domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RWDD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1:
SP2:
SP3: - -

Relevant External Links for RWDD1 Gene

GeneLoc Exon Structure for
RWDD1
ECgene alternative splicing isoforms for
RWDD1

Expression for RWDD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RWDD1 Gene

Protein differential expression in normal tissues from HIPED for RWDD1 Gene

This gene is overexpressed in Skin (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RWDD1 Gene



Protein tissue co-expression partners for RWDD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RWDD1 Gene:

RWDD1

SOURCE GeneReport for Unigene cluster for RWDD1 Gene:

Hs.532164

Evidence on tissue expression from TISSUES for RWDD1 Gene

  • Liver(4.3)
  • Heart(2)
genes like me logo Genes that share expression patterns with RWDD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RWDD1 Gene

Orthologs for RWDD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RWDD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RWDD1 34 33
  • 99.86 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RWDD1 33 34
  • 95.34 (n)
dog
(Canis familiaris)
Mammalia RWDD1 34 33
  • 94.1 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RWDD1 34
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rwdd1 33
  • 90.12 (n)
mouse
(Mus musculus)
Mammalia Rwdd1 34 16 33
  • 89.03 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RWDD1 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves RWDD1 34 33
  • 83.33 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RWDD1 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rwdd1 33
  • 72.94 (n)
Str.14743 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8141 33
zebrafish
(Danio rerio)
Actinopterygii rwdd1 34 33
  • 73 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5515 33 34
  • 49.53 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003063 33
  • 49.45 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_T26E3.4 33
  • 48.86 (n)
T26E3.4 34
  • 31 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GIR2 34
  • 26 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G51730 33
  • 48.41 (n)
rice
(Oryza sativa)
Liliopsida Os01g0558300 33
  • 53.72 (n)
Species where no ortholog for RWDD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RWDD1 Gene

ENSEMBL:
Gene Tree for RWDD1 (if available)
TreeFam:
Gene Tree for RWDD1 (if available)

Paralogs for RWDD1 Gene

Pseudogenes.org Pseudogenes for RWDD1 Gene

genes like me logo Genes that share paralogs with RWDD1: view

No data available for Paralogs for RWDD1 Gene

Variants for RWDD1 Gene

Sequence variations from dbSNP and Humsavar for RWDD1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000231788 -- 116,584,729(+) TAGCT(A/G)TCCAG reference, missense, utr-variant-5-prime
rs1000243613 -- 116,572,456(+) TGAGA(C/T)TGAGA intron-variant
rs1000858764 -- 116,586,310(+) TTAAT(A/T)GTCTA intron-variant
rs1000910632 -- 116,578,438(+) AAGTG(A/G)TGCTC intron-variant
rs1001177463 -- 116,578,305(+) TTCTT(C/T)CTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RWDD1 Gene

Variant ID Type Subtype PubMed ID
nsv830783 CNV gain 17160897
nsv523972 CNV gain 19592680
esv3571369 CNV loss 25503493

Variation tolerance for RWDD1 Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RWDD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RWDD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RWDD1 Gene

Disorders for RWDD1 Gene

Relevant External Links for RWDD1

Genetic Association Database (GAD)
RWDD1
Human Genome Epidemiology (HuGE) Navigator
RWDD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RWDD1

No disorders were found for RWDD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RWDD1 Gene

Publications for RWDD1 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 60
  2. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira AR … Marazita ML (Genetics in medicine : official journal of the American College of Medical Genetics 2008) 3 45 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for RWDD1 Gene

Sources for RWDD1 Gene

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