Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RUVBL1 Gene

protein-coding   GIFtS: 67
GCID: GC03M127783

RuvB-Like AAA ATPase 1

(Previous names: RuvB (E coli homolog)-like 1, RuvB-like 1 (E. coli), RuvB-like...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RuvB-Like AAA ATPase 11 2     TIP60-Associated Protein 54-Alpha2 3
INO80 Complex Subunit H1 2 3     pontin1
NMP2382 3 5     RuvB-Like 1 (E. Coli)1
TIP492 3 5     RuvB-Like AAA ATPase1
RuvB (E Coli Homolog)-Like 11 2     ECP542
Nuclear Matrix Protein 2382 3     PONTIN2
Pontin 522 3     Pontin522
49 KDa TATA Box-Binding Protein-Interacting Protein2 3     RVB12
49 KDa TBP-Interacting Protein2 3     TIH12
54 KDa Erythrocyte Cytosolic Protein2 3     RuvB-Like 12
ECP-542 3     TATA Binding Protein Interacting Protein 49 KDa2
INO80H2 3     EC 3.6.4.123
TAP54-alpha2 3     TIP49a3
TIP49A2 3     EC 3.6.18
NMP 2382 3     

External Ids:    HGNC: 104741   Entrez Gene: 86072   Ensembl: ENSG000001757927   OMIM: 6034495   UniProtKB: Q9Y2653   

Export aliases for RUVBL1 gene to outside databases

Previous GC identifers: GC03U990096 GC03M127983 GC03M129065 GC03M129120 GC03M129282 GC03M125180


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RUVBL1 Gene: 
RUVBL1 (RuvB-like AAA ATPase 1) is a protein-coding gene. Diseases associated with RUVBL1 include eaf, and polymyositis, and among its related super-pathways are Wnt Signaling Pathway and Packaging Of Telomere Ends. GO annotations related to this gene include DNA helicase activity and ATPase activity.

UniProtKB/Swiss-Prot: RUVB1_HUMAN, Q9Y265
Function: Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity;
hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure
contribute to the ATPase activity
Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation
of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter
nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which
positively regulate transcription. This complex may be required for the activation of transcriptional programs
associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest
and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to
be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct
role in DNA repair when recruited to sites of DNA damage
Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional
regulation, DNA replication and probably DNA repair
Function: Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation
by the LEF1/TCF1-CTNNB1 complex. Essential for cell proliferation
Function: May be able to bind plasminogen at cell surface and enhance plasminogen activation

Gene Wiki entry for RUVBL1 (RuvB-like 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RUVBL1 gene promoter:
         COUP-TF1   TBP   COUP-TF   TFIID   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRUVBL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RUVBL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RUVBL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3q21

RUVBL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RUVBL1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M127783:  view genomic region     (about GC identifiers)

Start:
127,783,621 bp from pter      End:
127,872,757 bp from pter
Size:
89,137 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RUVB1_HUMAN, Q9Y265 (See protein sequence)
Recommended Name: RuvB-like 1  
Size: 456 amino acids; 50228 Da
Subunit: Forms homohexameric rings. Can form a dodecamer with RUVBL2 made of two stacked hexameric rings; however,
even though RUVBL1 and RUVBL2 are present in equimolar ratio, the oligomeric status of each hexamer is not known.
Oligomerization may regulate binding to nucleic acids and conversely, binding to nucleic acids may affect the
dodecameric assembly. Interacts with the transcriptional activation domain of MYC. Component of the RNA
polymerase II holoenzyme complex. May also act to bridge the LEF1/TCF1-CTNNB1 complex and TBP. Component of the
NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400,
TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15,
MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus
E1A protein. RUVBL1 interacts with EP400. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400,
SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41.
Component of the BAF53 complex, at least composed of ACTL6A/BAF53A, RUVBL1/TIP49, SMARCA2/BRM, and TRRAP/PAF400.
Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5
and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1,
MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and
TEX10. Associates with alpha and gamma tubulins, particularly during metaphase and early anaphase. Interacts with
NPAT. Component of the chromatin-remodeling INO80 complex; specifically part of a complex module associated with
the helicase ATP-binding and the helicase C-terminal domain of INO80. Interacts with IGHMBP2. Interacts with
OFD1. Interacts with HINT1
Subcellular location: Nucleus matrix. Nucleus, nucleoplasm. Cytoplasm. Membrane. Cytoplasm, cytoskeleton,
microtubule organizing center, centrosome. Note=Mainly localized in the nucleus, associated with nuclear matrix
or in the nuclear cytosol, although it is also present in the cytoplasm and associated with the cell membranes.
In prophase and prometaphase it is located at the centrosome and the branching microtubule spindles. After
mitotic nuclear membrane disintigration it accumulates at the centrosome and sites of tubulin polymerization. As
cells pass through metaphase and into telophase it is located close to the centrosome at the early phase of
tubulin polymerization. In anaphase it accumulates at the zone of tubule interdigitation. In telophase it is
found at polar tubule overlap, and it reappears at the site of chromosomal decondensation in the daughter cells
Miscellaneous: High level of autoantibodies against RUVBL1 are detected in sera of patients with autoimmune
diseases such as polymyositis/dermatomyosistis and autoimmune hepatitis
2 PDB 3D structures from and Proteopedia for RUVBL1:
2C9O (3D)        2XSZ (3D)    
Secondary accessions: B2R5S0 P82276 Q1KMR0 Q53HK5 Q53HL7 Q53Y27 Q9BSX9
Alternative splicing: 2 isoforms:  Q9Y265-1   Q9Y265-2   

Explore the universe of human proteins at neXtProt for RUVBL1: NX_Q9Y265

Explore proteomics data for RUVBL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y265

  • 4/27 DME Specific Peptides for RUVBL1 (Q9Y265) (see all 27)
     LMENFRR  MLDIECF  EMKQIIK  ATEFDLE 

    RUVBL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RUVBL1 Protein Expression
    REFSEQ proteins: NP_003698.1  
    ENSEMBL proteins: 
     ENSP00000463669   ENSP00000417370   ENSP00000420738   ENSP00000318297   ENSP00000417254  
     ENSP00000393755  
    Reactome Protein details: Q9Y265
    Human Recombinant Protein Products for RUVBL1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RUVBL1
    OriGene Protein Over-expression Lysate for RUVBL1
    OriGene MassSpec for RUVBL1 
    OriGene Custom Protein Services for RUVBL1
    GenScript Custom Purified and Recombinant Proteins Services for RUVBL1
    Novus Biologicals RUVBL1 Proteins
    Novus Biologicals RUVBL1 Lysate
    Sino Biological Recombinant Protein for RUVBL1
    Sino Biological Cell Lysate for RUVBL1 
    ProSpec Recombinant Protein for RUVBL1
    Cloud-Clone Corp. Proteins for RUVBL1 

    Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--

    RUVBL1 for ontologies           About GeneDecksing



    RUVBL1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RUVBL1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for RUVBL1 
    OriGene Antibodies for RUVBL1
    OriGene Custom Antibody Services for RUVBL1
    GenScript Custom Superior Antibodies Services for RUVBL1
    Novus Biologicals RUVBL1 Antibodies
    Abcam antibodies for RUVBL1
    Cloud-Clone Corp. Antibodies for RUVBL1 
    ThermoFisher Antibody for RUVBL1
    LSBio Antibodies in human, mouse, rat for RUVBL1 

    Assay Products for RUVBL1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RUVBL1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RUVBL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RUVBL1 
    Cloud-Clone Corp. CLIAs for RUVBL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    INO80: INO80 complex subunits
    AATP: ATPases / AAA-type

    5 InterPro protein domains:
     IPR012340 NA-bd_OB-fold
     IPR027238 RuvB-like
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase
     IPR010339 TIP49_C

    Graphical View of Domain Structure for InterPro Entry Q9Y265

    ProtoNet protein and cluster: Q9Y265

    1 Blocks protein domain: IPB010339 TIP49

    UniProtKB/Swiss-Prot: RUVB1_HUMAN, Q9Y265
    Domain: Binding to MYC is dependent on a Myc domain essential for oncogenic activity
    Similarity: Belongs to the RuvB family


    RUVBL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RUVB1_HUMAN, Q9Y265
    Function: Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity;
    hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure
    contribute to the ATPase activity
    Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation
    of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter
    nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which
    positively regulate transcription. This complex may be required for the activation of transcriptional programs
    associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest
    and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to
    be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct
    role in DNA repair when recruited to sites of DNA damage
    Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional
    regulation, DNA replication and probably DNA repair
    Function: Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation
    by the LEF1/TCF1-CTNNB1 complex. Essential for cell proliferation
    Function: May be able to bind plasminogen at cell surface and enhance plasminogen activation
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Genatlas biochemistry entry for RUVBL1:
    E coli RUVB homolog-like 1,component of a large nuclear protein complex,possibly the RNA polymerase II
    holozyme,interacting with RUVBL2 and stomatin,localized to tohe nucleus and cytoplasm suggesting an additional
    function as chaperone components.

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.121

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003678DNA helicase activity IDA9843967
    GO:0005515protein binding IPI10966108
    GO:0005524ATP binding IEA--
    GO:0009378four-way junction helicase activity ----
         
    RUVBL1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for RUVBL1:
     Decreased viability  Decreased viability of wild-ty  Increased cell death in HCC-19  Wnt reporter downregulated 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ruvbl1):
     homeostasis/metabolism 

    RUVBL1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RUVBL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RUVBL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RUVBL1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RUVBL1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RUVBL1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate RUVBL1:
    hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidRUVBL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RUVBL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RUVBL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RUVBL1
    Sirion Biotech Customized adenovirus for overexpression of RUVBL1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RUVBL1 (see all 7)
    OriGene ORF clones in mouse, rat for RUVBL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RUVBL1 (NM_003707)
    Sino Biological Human cDNA Clone for RUVBL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RUVBL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUVBL1
    Sirion Biotech Customized lentivirus for stable overexpression of RUVBL1 
                         Customized lentivirus expression plasmids for stable overexpression of RUVBL1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RUVBL1
    Search LifeMap BioReagents cell lines for RUVBL1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUVBL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RUVBL1 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    2Packaging Of Telomere Ends
    Nucleosome assembly0.46
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.46
    3Cell Cycle
    Cell Cycle0.84
    4Meiotic Synapsis
    Chromosome Maintenance0.56
    5Validated targets of C-MYC transcriptional activation
    Validated targets of C-MYC transcriptional activation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for RUVBL1
        Chromatin Regulation / Acetylation

    4 BioSystems Pathways for RUVBL1
        Gastric cancer network 1
    Wnt Signaling Pathway NetPath
    C-MYC pathway
    Validated targets of C-MYC transcriptional activation


    4        Reactome Pathways for RUVBL1
        Nucleosome assembly
    Cell Cycle
    Deposition of New CENPA-containing Nucleosomes at the Centromere
    Chromosome Maintenance


    1         Kegg Pathway  (Kegg details for RUVBL1):
        Wnt signaling pathway


    RUVBL1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RUVBL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1202 Interacting proteins for RUVBL1 (Q9Y2651, 2, 3 ENSP000003182974) via UniProtKB, MINT, STRING, and/or I2D (see all 1202)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=3 
    HIST1H4BP628053I2D: score=3 
    HIST1H4CP628053I2D: score=3 
    HIST1H4DP628053I2D: score=3 
    HIST1H4EP628053I2D: score=3 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination IEA--
    GO:0006334nucleosome assembly TAS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9813143

    RUVBL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RUVBL1 (RUVB1)

    Search CenterWatch for drugs/clinical trials and news about RUVBL1 / RUVB1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RUVBL1 gene: 
    NM_003707.2  

    Unigene Cluster for RUVBL1:

    RuvB-like 1 (E. coli)
    Hs.272822  [show with all ESTs]
    Unigene Representative Sequence: BX647488
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000585057 ENST00000472125 ENST00000464873(uc003ekf.3) ENST00000322623(uc003ekh.3 uc010hss.3)
    ENST00000582176 ENST00000478892 ENST00000480616 ENST00000478243 ENST00000417360

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RUVBL1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate RUVBL1:
    hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidRUVBL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RUVBL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RUVBL1
    Clone
    Products:
         
    OriGene clones in human, mouse for RUVBL1 (see all 7)
    OriGene ORF clones in mouse, rat for RUVBL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RUVBL1 (NM_003707)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RUVBL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUVBL1
    Sirion Biotech Customized lentivirus for stable overexpression of RUVBL1 
                         Customized lentivirus expression plasmids for stable overexpression of RUVBL1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RUVBL1
    OriGene qSTAR qPCR primer pairs in human, mouse for RUVBL1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RUVBL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RUVBL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RUVBL1

    Additional mRNA sequence: 

    AB012122.1 AB451224.1 AB451347.1 AF070735.1 AF099084.1 AJ010058.1 AK092163.1 AK222563.1 
    AK222575.1 AK312290.1 BC002993.1 BC012886.1 BT007057.1 BX647488.1 DQ469310.1 Y18418.1 

    22 DOTS entries:

    DT.120891496  DT.100726604  DT.118699  DT.120891067  DT.91774522  DT.100882746  DT.100882772  DT.95225252 
    DT.100882736  DT.91995405  DT.120891303  DT.405564  DT.95225294  DT.100882743  DT.120891046  DT.120891048 
    DT.91774549  DT.95225263  DT.95225337  DT.102838773  DT.120891234  DT.91639332 

    24/507 AceView cDNA sequences (see all 507):

    AA312340 BM676368 AA765267 BQ685917 BE281390 BP353326 BM824068 BQ890070 
    CA429506 BM909141 AA299939 BM793869 BM457207 BF794804 BU168927 BQ925477 
    BQ436580 CA441144 BF220143 BE385957 BM552192 BM916530 AL553383 BP376188 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RUVBL1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
    SP1:                                                              -           -               
    SP2:                                      -     -                 -           -               
    SP3:                                                                          -               
    SP4:                    -                                                                     
    SP5:                                                                                          


    ECgene alternative splicing isoforms for RUVBL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RUVBL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTGAGATG
    RUVBL1 Expression
    About this image


    See RUVBL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RUVBL1

    SOURCE GeneReport for Unigene cluster: Hs.272822

    UniProtKB/Swiss-Prot: RUVB1_HUMAN, Q9Y265
    Tissue specificity: Ubiquitously expressed with high expression in heart, skeletal muscle and testis

        SABiosciences Expression via Pathway-Focused PCR Array including RUVBL1: 
              WNT Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RUVBL1
    OriGene qSTAR qPCR primer pairs in human, mouse for RUVBL1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RUVBL1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RUVBL1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RUVBL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUVBL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RUVBL1 gene from 10/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ruvbl11 , 5 RuvB-like protein 11, 5 89.4(n)1
    99.78(a)1
      6 (39.51 cM)5
    565051  NM_019685.21  NP_062659.11 
     884654095 
    chicken
    (Gallus gallus)
    Aves RUVBL11 RuvB-like 1 (E. coli) 83.19(n)
    96.27(a)
      416022  NM_001006138.1  NP_001006138.1 
    lizard
    (Anolis carolinensis)
    Reptilia RUVBL16
    Uncharacterized protein
    97(a)
    1 ↔ 1
    2(165682959-165705360)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.79522 Xenopus laevis pontin mRNA, complete cds 81.55(n)    AF218072.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ruvbl12 RuvB-like 1 (E. coli) 77.13(n)   317679  AY092764.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pont1 , 3 DNA helicase3
    pontin1
    79(a)3
    70.11(n)1
    79.56(a)1
      86A33
    534391  NM_144351.31  NP_652608.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C27H6.23
    ruvb-11
    Yeast hypothetical 50.5 KD protein like3
    Protein RUVB-11
    60(a)3
    60.05(n)1
    63.36(a)1
      V(9981625-9983285)3
    1793881  NM_073166.31  NP_505567.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RVB1(YDR190C)4
    RVB11
    Essential protein involved in transcription regulation; more4
    Rvb1p1
    62.21(n)1
    70.74(a)1
      4(841995-840604)4
    8517711, 4  NP_010476.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RIN11 RuvB-like protein 1 67.4(n)
    73.13(a)
      832293  NM_122138.2  NP_197625.1 
    rice
    (Oryza sativa)
    Liliopsida Os.380332 Oryza sativa (japonica cultivar-group) cDNA clone0 more 76.05(n)    AK105439.1 


    ENSEMBL Gene Tree for RUVBL1 (if available)
    TreeFam Gene Tree for RUVBL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RUVBL1 gene
    1 SIMAP similar gene for RUVBL1 using alignment to 6 protein entries:     RUVB1_HUMAN (see all proteins):
    RUVBL2

    RUVBL1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RUVBL1
    PGOHUM00000250253


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/852 SNPs in RUVBL1 are shown (see all 852)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1465027601,2
    --127799342(+) TGAGTC/GATGTT 1 -- int10--------
    rs1486937271,2
    --127799556(+) TGTCAC/TAGCCA 1 -- int10--------
    rs15545341,2
    C,F,A,H--127799669(-) ttattA/Ctactg 1 -- int134Minor allele frequency- C:0.11NS EA NA WA CSA 2922
    rs681185841,2
    C--127799836(+) AACTT-/AGAG  
            
    AGAGA
    1 -- ut310--------
    rs40581571,2
    C--127799851(+) AGAGA-/GAGA  
            
    ATCAA
    2 -- ut31 cds11Minor allele frequency- GAGA:0.00NA 2
    rs729740821,2
    C--127799920(+) GCAACC/TACAGG 1 -- ut311Minor allele frequency- T:0.50WA 2
    rs67796791,2
    C,H--127799935(+) GTTACG/AATAAC 1 -- ut314Minor allele frequency- A:0.00NS EA 408
    rs1421623971,2
    C--127799975(+) GACAGC/TGCTGC 1 -- ut310--------
    rs10572201,2
    C,F,A,H--127799983(-) CGTGGT/GCTGCA 1 -- ut31 ese324Minor allele frequency- G:0.20MN NS EA NA WA CSA 2652
    rs2019919741,2
    C--127800058(+) ACACCG/TGGGGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RUVBL1 (127783621 - 127872757 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RUVBL1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3992CNV Insertion18451855
    nsv3991CNV Insertion18451855
    nsv508951CNV Insertion20534489


    Human Gene Mutation Database (HGMD): RUVBL1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RUVBL1
    DNA2.0 Custom Variant and Variant Library Synthesis for RUVBL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603449    OMIM disorders: --

    12 diseases for RUVBL1:    About MalaCards
    eaf    polymyositis    autoimmune hepatitis    endocarditis
    ovarian cancer    cervicitis    colon cancer    hypoxia
    prostate cancer    prostatitis    hepatitis    breast cancer


    RUVBL1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for RUVBL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune diseases 15.5 1 9588198 (1)

    Genetic Association Database (GAD): RUVBL1
    Human Genome Epidemiology (HuGE) Navigator: RUVBL1 (2 documents)

    Export disorders for RUVBL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RUVBL1 gene, integrated from 9 sources (see all 140):
    (articles sorted by number of sources associating them with RUVBL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An eukaryotic RuvB-like protein (RUVBL1) essential for growth. (PubMed id 9774387)1, 2, 3, 9 Qiu X.-B.... Dutta A. (1998)
    2. TIP49, homologous to the bacterial DNA helicase RuvB, acts as an autoantigen in human. (PubMed id 9588198)1, 2, 3, 9 Makino Y.... Tamura T.-A. (1998)
    3. TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a. (PubMed id 10428817)1, 2, 9 Kanemaki M.... Tamura T.-A. (1999)
    4. TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling. (PubMed id 14695187)1, 2, 9 Feng Y.... Fearon E.R. (2003)
    5. Isolation, molecular characterization, and tissue-specific expression of ECP-51 and ECP-54 (TIP49), two homologous, interacting erythroid cytosolic proteins. (PubMed id 10524211)1, 2, 9 Salzer U.... Prohaska R. (1999)
    6. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PubMed id 16230350)1, 2, 9 Jin J.... Conaway J.W. (2005)
    7. An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc. (PubMed id 10882073)1, 2, 9 Wood M.A.... Cole M.D. (2000)
    8. Functional characterization of the OFD1 protein reveals a nuclear localization and physical interaction with subunits of a chromatin remodeling complex. (PubMed id 17761535)1, 2, 9 Giorgio G....Franco B. (2007)
    9. BAF53 forms distinct nuclear complexes and functions as a critical c- Myc-interacting nuclear cofactor for oncogenic transformation. (PubMed id 11839798)1, 2, 9 Park J.... Cole M.D. (2002)
    10. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PubMed id 21303910)1, 2 Chen L.... Conaway R.C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8607 HGNC: 10474 AceView: RUVBL1 Ensembl:ENSG00000175792 euGenes: HUgn8607
    ECgene: RUVBL1 Kegg: 8607 H-InvDB: RUVBL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RUVBL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RUVBL1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RUVBL1 gene:
    Search GeneIP for patents involving RUVBL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of RUVBL1
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RUVBL1   OriGene RNAi products in human, mouse, rat for RUVBL1  
     OriGene qPCR primer pairs and template standards for RUVBL1   OriGene Protein Over-expression Lysate for RUVBL1  
     OriGene MassSpec something-or-other for RUVBL1   OriGene clones in human, mouse for RUVBL1  
     OriGene qSTAR qPCR primer pairs in human, mouse for RUVBL1   OriGene Purified Protein for RUVBL1  
     OriGene ORF clones in mouse, rat for RUVBL1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RUVBL1   OriGene Custom Protein Services for RUVBL1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RUVBL1
     QIAGEN SeqTarget long-range PCR primers for resequencing RUVBL1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RUVBL1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RUVBL1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RUVBL1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RUVBL1
     GenScript Custom Purified and Recombinant Proteins Services for RUVBL1 GenScript cDNA clones with any tag delivered in your preferred vector for RUVBL1
     GenScript Custom Assay Services for RUVBL1 GenScript Custom Superior Antibodies Services for RUVBL1
     GenScript Custom overexpressing Cell Line Services for RUVBL1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for RUVBL1 

     Regulatory tfbs in RUVBL1 promoter
     Search Chromatin IP Primers for RUVBL1
     RT2 qPCR Primer Assay in human, mouse, rat RUVBL1
     GNC Network for RUVBL1
     SABiosciences PCR Arrays including human, mouse, rat RUVBL1
     Search Tocris compounds for RUVBL1 (RUVB1)
     Proteins and Antibodies for RUVBL1
     Cell Lysates for RUVBL1
     cDNA Clones for RUVBL1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RUVBL1 antibodies
     RUVBL1 proteins
     RUVBL1 lysates
     Antibodies for RUVBL1
     See all of Abcam's Antibodies, Kits and Proteins for RUVBL1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for RUVBL1




     Proteins for RUVBL1
     Antibodies for RUVBL1
     ELISAs for RUVBL1
     CLIAs for RUVBL1
     Search LifeMap BioReagents cell lines for RUVBL1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUVBL1
     SwitchGear 3'UTR luciferase reporter plasmids for RUVBL1
     SwitchGear Promoter luciferase reporter plasmids for RUVBL1
     ThermoFisher Antibody for RUVBL1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUVBL1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RUVBL1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RUVBL1
    Customized:
     lentivirus for stable overexpression of RUVBL1
     lentivirus expression plasmids for stable overexpression of RUVBL1
     adenovirus for overexpression of RUVBL1
     LSBio Antibodies in human, mouse, rat for RUVBL1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RUVBL1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4