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RUSC2 Gene

protein-coding   GIFtS: 53
GCID: GC09P035490

RUN And SH3 Domain Containing 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RUN And SH3 Domain Containing 21 2     Iporin2
Interacting Protein Of Rab12 3     iporin2
RUN And SH3 Domain-Containing Protein 22 3     IPORIN5
KIAA03753 5     

External Ids:    HGNC: 236251   Entrez Gene: 98532   Ensembl: ENSG000001988537   OMIM: 6110535   UniProtKB: Q8N2Y83   

Export aliases for RUSC2 gene to outside databases

Previous GC identifers: GC09P035536 GC09P035482 GC09P035483 GC09P035444


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RUSC2 Gene:
This gene encodes a RUN and SH3 domain containing protein that interacts with Rab1b and Rab1-binding protein
GM130. Alternatively spliced transcript variants have been observed for this gene. (provided by RefSeq, Jun 2012)

GeneCards Summary for RUSC2 Gene:
RUSC2 (RUN and SH3 domain containing 2) is a protein-coding gene. Diseases associated with RUSC2 include hiv-1. An important paralog of this gene is RUSC1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RUSC2 gene promoter:
         LHX3b/Lhx3b   p53   Pax-6   LHX3a/Lhx3a   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRUSC2 promoter sequence
   Search Chromatin IP Primers for RUSC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RUSC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13.2

RUSC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RUSC2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P035490:  view genomic region     (about GC identifiers)

Start:
35,490,007 bp from pter      End:
35,561,895 bp from pter
Size:
71,889 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RUSC2_HUMAN, Q8N2Y8 (See protein sequence)
Recommended Name: Iporin  
Size: 1516 amino acids; 161225 Da
Subunit: Interacts with active RAB1A and RAB1B, and with GOLGA2
Sequence caution: Sequence=BAA20830.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A2RU62 A7E2A9 O15080 Q5W134 Q641Q6 Q6P1W7

Explore the universe of human proteins at neXtProt for RUSC2: NX_Q8N2Y8

Explore proteomics data for RUSC2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RUSC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129471.1  NP_055621.1  

    ENSEMBL proteins: 
     ENSP00000355177   ENSP00000393922  

    RUSC2 Human Recombinant Protein Products:

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    RUSC2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for RUSC2
    Cloud-Clone Corp. CLIAs for RUSC2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011511 SH3_2
     IPR001452 SH3_domain
     IPR004012 Run

    Graphical View of Domain Structure for InterPro Entry Q8N2Y8

    ProtoNet protein and cluster: Q8N2Y8

    2 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: RUSC2_HUMAN, Q8N2Y8
    Domain: The RUN domain is required for the interaction with RAB1A and RAB1B
    Similarity: Contains 1 RUN domain
    Similarity: Contains 1 SH3 domain


    RUSC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    RUSC2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for RUSC2:
     Decreased Tat-dependent transc  Decreased p24 protein expressi  Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RUSC2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RUSC2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RUSC2

    miRNA
    Products:
        
    miRTarBase miRNAs that target RUSC2:
    hsa-mir-324-5p (MIRT043200)

    Block miRNA regulation of human, mouse, rat RUSC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RUSC2 (see all 26):
    hsa-miR-485-5p hsa-miR-125a-5p hsa-miR-1226 hsa-miR-429 hsa-miR-323b-3p hsa-miR-650 hsa-miR-4298 hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidRUSC2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RUSC2
    Predesigned siRNA for gene silencing in human, mouse, rat RUSC2

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for RUSC2
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    GenScript: all cDNA clones in your preferred vector (see all 2): RUSC2 (NM_014806)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RUSC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUSC2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for RUSC2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUSC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RUSC2_HUMAN, Q8N2Y8: Cytoplasm, cytosol. Note=Cytosolic punctate distribution. Also observed in the perinuclear
    region
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    extracellular1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    RUSC2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RUSC2
    Interactions:

        GeneGlobe Interaction Network for RUSC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for RUSC2 (Q8N2Y82, 3 ENSP000003551774) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB1BQ9H0U42, 3, ENSP000003102264MINT-61270 MINT-61269 MINT-61266 I2D: score=3 STRING: ENSP00000310226
    GOLGA2Q083792, 3, ENSP000004160974MINT-61271 I2D: score=4 STRING: ENSP00000416097
    RAB1AP628202, 3, ENSP000003872864MINT-61267 I2D: score=1 STRING: ENSP00000387286
    SRPRP082402, 3, ENSP000003280234MINT-64905 I2D: score=4 STRING: ENSP00000328023
    MAGEC1O607323, ENSP000002858794I2D: score=2 STRING: ENSP00000285879
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RUSC2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RUSC2 gene (2 alternative transcripts): 
    NM_001135999.1  NM_014806.2  

    Unigene Cluster for RUSC2:

    RUN and SH3 domain containing 2
    Hs.493796  [show with all ESTs]
    Unigene Representative Sequence: NM_001135999
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361226(uc003zww.3 uc010mkq.3) ENST00000468041 ENST00000455600(uc003zwx.4)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RUSC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RUSC2 (see all 26):
    hsa-miR-485-5p hsa-miR-125a-5p hsa-miR-1226 hsa-miR-429 hsa-miR-323b-3p hsa-miR-650 hsa-miR-4298 hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidRUSC2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RUSC2
    Predesigned siRNA for gene silencing in human, mouse, rat RUSC2
    Clone
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    OriGene clones in human, mouse for RUSC2 (see all 12)
    OriGene ORF clones in mouse, rat for RUSC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RUSC2 (NM_014806)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RUSC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUSC2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RUSC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RUSC2
      QuantiTect SYBR Green Assays in human, mouse, rat RUSC2
      QuantiFast Probe-based Assays in human, mouse, rat RUSC2

    Additional mRNA sequence: 

    AB002373.2 AK299805.1 BC029647.1 BC064843.1 BC082245.1 BC132766.1 BC132770.1 BC146654.1 
    BC150211.1 BC150262.1 NR_052015.1 

    8 DOTS entries:

    DT.442057  DT.100780724  DT.121186007  DT.75168051  DT.91758618  DT.95150192  DT.99944836  DT.100718207 

    Selected AceView cDNA sequences (see all 136):

    BM714654 F01436 BQ940637 BI868320 BM980479 BQ956292 BU509159 AL042446 
    BX503719 BQ938092 BU608610 C01894 AI241021 AI903139 BQ009921 BQ695037 
    T06139 AI201265 CA946274 BU739284 BQ716760 AW294498 AL138215 BF955749 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RUSC2 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
    SP1:                                                                                                                        
    SP2:                                      -                                                                                 
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for RUSC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RUSC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGAAGACA
    RUSC2 Expression
    About this image

    RUSC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RUSC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.493796

    UniProtKB/Swiss-Prot: RUSC2_HUMAN, Q8N2Y8
    Tissue specificity: Widely expressed, with highest levels in brain and testis

        Custom PCR Arrays for RUSC2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUSC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RUSC2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rusc21 , 5 RUN and SH3 domain containing 21, 5 85.32(n)1
    86.41(a)1
      4 (23.03 cM)5
    1002131  NM_001037709.21  NP_001032798.11 
     433819795 
    chicken
    (Gallus gallus)
    Aves RUSC21 RUN and SH3 domain containing 2 65(n)
    63.51(a)
      431657  XM_003642968.2  XP_003643016.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    64(a)
    55(a)
    many → 1
    many → 1
    AAWZ02037390(2142-14311)
    GL343585.1(95842-97611)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rusc21 RUN and SH3 domain containing 2 59.97(n)
    57.05(a)
      100490674  XM_002940191.2  XP_002940237.2 
    zebrafish
    (Danio rerio)
    Actinopterygii rusc21 RUN and SH3 domain containing 2 55.43(n)
    53.8(a)
      556081  XM_005165190.1  XP_005165247.1 


    ENSEMBL Gene Tree for RUSC2 (if available)
    TreeFam Gene Tree for RUSC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RUSC2 gene
    RUSC12  

    RUSC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RUSC2 (see all 1360)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1379586791,2
    Cuntested135525973(+) AACATC/TGCTGT 3 I syn11Minor allele frequency- T:0.00NA 4552
    rs625432511,2
    C--35456028(+) ACCCAA/GGCGGG 2 -- us2k12Minor allele frequency- G:0.13NA EA 122
    rs1852290361,2
    --35456178(+) GGTGCC/TCCCAG 2 -- us2k10--------
    rs1121175211,2
    F--35456194(+) CATACG/CTCACC 2 -- us2k12Minor allele frequency- C:0.50CSA 4
    rs1485970041,2
    --35456466(+) CAAAAG/TAAGGA 2 -- us2k10--------
    rs1429809241,2
    --35456471(+) GAAGGA/CAAGCA 2 -- us2k10--------
    rs1461085421,2
    C--35456509(+) CCACAA/GTGTGG 2 -- us2k10--------
    rs1401365071,2
    --35456575(+) TACCCC/GCTAGA 2 -- us2k10--------
    rs600821181,2
    C,F--35456619(+) ATGAAT/GTCGTA 2 -- us2k14Minor allele frequency- G:0.20NS CSA WA NA 307
    rs1900622391,2
    --35456934(+) TTAGGA/TTCCCT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for RUSC2 (35490007 - 35561895 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for RUSC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv512987CNV Insertion21212237
    esv1015523CNV Insertion17803354
    esv1590335CNV Insertion17803354
    nsv528256CNV Loss19592680
    nsv831545CNV Loss17160897
    nsv527028CNV Loss19592680
    dgv8167n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RUSC2
    DNA2.0 Custom Variant and Variant Library Synthesis for RUSC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611053    OMIM disorders: --

    1 disease for RUSC2:    
    About MalaCards
    hiv-1


    RUSC2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RUSC2
    Human Genome Epidemiology (HuGE) Navigator: RUSC2 (1 document)

    Export disorders for RUSC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RUSC2 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with RUSC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1997)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Identification and characterization of Iporin as a novel interaction partner for rab1. (PubMed id 15796781)1, 2 Bayer M.... Barnekow A. (BMC Cell Biol. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Characterization of RUSC1 and RUSC2 genes in silico. (PubMed id 15375525)1, 9 Katoh M. and Katoh M. (Oncol. Rep. 2004)
    6. Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome. (PubMed id 22745667)1 Asbach B....Wagner R. (PLoS ONE 2012)
    7. Genome-wide investigation of the Rab binding activity of RUN domains: development of a novel tool that specifically traps GTP-Rab35. (PubMed id 21737958)1 Fukuda M....Ohbayashi N. (Cell Struct. Funct. 2011)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9853 HGNC: 23625 AceView: RUSC2 Ensembl:ENSG00000198853 euGenes: HUgn9853
    ECgene: RUSC2 H-InvDB: RUSC2

    (According to HUGE)
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    HUGE: KIAA0375

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RUSC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RUSC2 gene:
    Search GeneIP for patents involving RUSC2

    GeneCards and IP:
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