RUSC2 Gene
protein-coding GIFtS: 50
GCID: GC09P035490
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RUN and SH3 domain containing 2
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Aliases
for RUSC2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RUN And SH3 Domain Containing 21 2 | | Iporin2 | | KIAA03751 3 5 | | Iporin2 | | Interacting Protein Of Rab12 3 | | IPORIN5 | | RUN And SH3 Domain-Containing Protein 22 3 | | |
Export aliases for RUSC2 gene to outside databasesPrevious GC identifers: GC09P035536 GC09P035482 GC09P035483 GC09P035444 |
Summaries
for RUSC2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RUSC2:
This gene encodes a RUN and SH3 domain containing protein that interacts with Rab1b and Rab1-binding protein GM130.Alternatively spliced transcript variants have been observed for this gene. (provided by RefSeq, Jun 2012)
|
Genomic Views
for RUSC2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RUSC2 gene promoter:
LHX3b/Lhx3b p53 Pax-6 LHX3a/Lhx3a C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for RUSC2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RUSC2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p13.3 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p13.2RUSC2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P035490: view genomic region
(about GC identifiers)
Start:
|
35,490,007 bp from pter |
End:
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35,561,895 bp from pter |
Size:
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71,889 bases |
Orientation:
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plus strand |
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Proteins
for RUSC2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RUSC2_HUMAN, Q8N2Y8 (See
protein sequence)Recommended Name: Iporin Size: 1516 amino acids; 161225 Da
Subunit: Interacts with active RAB1A and RAB1B, and with GOLGA2
Subcellular location: Cytoplasm, cytosol. Note=Cytosolic punctate distribution. Also observed in the perinuclear region
Sequence caution: Sequence=BAA20830.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A2RU62 A7E2A9 O15080 Q5W134 Q641Q6 Q6P1W7Explore the universe of human proteins at neXtProt for RUSC2: NX_Q8N2Y8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N2Y8
RUSC2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001129471.1 NP_055621.1
ENSEMBL proteins: ENSP00000355177 ENSP00000393922
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
IEA | -- |
RUSC2 for ontologies About GeneDecksing
RUSC2 Antibody Products:
Assay Products for RUSC2: |
Protein
Domains /
Families
for RUSC2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RUSC2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N2Y8ProtoNet protein and cluster: Q8N2Y8 2 Blocks protein families: IPB001452 SH3 domain signature IPB011511 Variant SH3
UniProtKB/Swiss-Prot: RUSC2_HUMAN, Q8N2Y8Domain: The RUN domain is required for the interaction with RAB1A and RAB1BSimilarity: Contains 1 RUN domainSimilarity: Contains 1 SH3 domain |
Function
for RUSC2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RUSC2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RUSC2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for RUSC2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUSC2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUSC2 |
4 GenomeRNAi human phenotypes for RUSC2:
|
Pathways & Interactions
for RUSC2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RUSC2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/14 Interacting proteins for RUSC2 (Q8N2Y82, 3 ENSP000003551774) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
|
Drugs & Compounds
for RUSC2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RUSC2
Search CenterWatch for drugs/clinical trials and news about RUSC2
|
Transcripts
for RUSC2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RUSC2 gene (2 alternative transcripts): NM_001135999.1 NM_014806.2 Unigene Cluster for RUSC2: RUN and SH3 domain containing 2 Hs.493796 [show with all ESTs]Unigene Representative Sequence: NM_0011359993 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000361226(uc003zww.3 uc010mkq.3) ENST00000468041 ENST00000455600(uc003zwx.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RUSC2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RUSC2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RUSC2 (NM_014806) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RUSC2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUSC2 |
Additional cDNA sequence: AB002373.2 AK299805.1 BC029647.1 BC064843.1 BC082245.1 BC132766.1 BC132770.1 BC146654.1 BC150211.1 BC150262.1 NR_052015.1 8 DOTS entries: DT.442057 DT.100780724 DT.121186007 DT.75168051 DT.91758618 DT.95150192 DT.99944836 DT.100718207 24/136 AceView cDNA sequences (see all 136): BM684428 BQ956292 BQ940637 BU741896 BQ938092 BF955749 BI754449 BU180572 BQ695037 BC064843 BM727159 BM682333 BU739284 BU608610 BX452115 BU145657 AI201265 BQ670125 BI868320 BU732797 CD516558 BC082245 AI241021 BX503721
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RUSC2 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RUSC2
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Expression
for RUSC2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RUSC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTGAAGACA
About this image
See RUSC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RUSC2
SOURCE GeneReport for Unigene cluster: Hs.493796
UniProtKB/Swiss-Prot: RUSC2_HUMAN, Q8N2Y8Tissue specificity: Widely expressed, with highest levels in brain and testis
SABiosciences Custom PCR Arrays for RUSC2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RUSC2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RUSC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RUSC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RUSC2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUSC2 |
Orthologs
for RUSC2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RUSC2 gene from 5/11 species (see all 11) About this table
ENSEMBL Gene Tree for RUSC2 (if available)
TreeFam Gene Tree for RUSC2 (if available) |
Paralogs
for RUSC2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RUSC2 gene
- RUSC12
RUSC2 for paralogs About GeneDecksing
|
Genomic Variants
for RUSC2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RUSC2 (35490007 - 35561895 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RUSC2
1 CNV: 4618 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RUSC2 |
|
Disorders
/ Diseases
for RUSC2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 RUSC2 for disorders About MalaCards
RUSC2 for disorders About GeneDecksing
OMIM gene information: 611053
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: RUSC2 (1 document)
Export disorders for RUSC2 gene to outside databases
|
Publications
for RUSC2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RUSC2 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with RUSC2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Identification and characterization of Iporin as a novel interaction partner for rab1. (PubMed id 15796781)1, 2 Bayer M.... Barnekow A. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization of RUSC1 and RUSC2 genes in silico. (PubMed id 15375525)1, 9 Katoh M. and Katoh M. (2004)
- Comprehensive analysis of interactions between the Src -associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome. (PubMed id 22745667)1 Asbach B....Wagner R. (2012)
- Genome-wide investigation of the Rab binding activity of RUN domains: development of a novel tool that specifically traps GTP-Rab35. (PubMed id 21737958)1 Fukuda M....Ohbayashi N. (2011)
- Regulation of epidermal growth factor receptor traffi cking by lysine deacetylase HDAC6. (PubMed id 20029029)1 Deribe Y.L....Dikic I. (2009)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
|
External Searches for RUSC2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RUSC2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RUSC2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing RUSC2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RUSC2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RUSC2 gene:
Search GeneIP for patents involving RUSC2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RUSC2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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 | | | RUSC2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUSC2 |
|  |  |  | | | | Search ThermoFisher Antibodies for RUSC2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUSC2 |
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