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Aliases for RUSC2 Gene

Aliases for RUSC2 Gene

  • RUN And SH3 Domain Containing 2 2 3
  • RUN And SH3 Domain-Containing Protein 2 3 4
  • Interacting Protein Of Rab1 3 4
  • KIAA0375 4 6
  • Iporin 3 6

External Ids for RUSC2 Gene

Summaries for RUSC2 Gene

Entrez Gene Summary for RUSC2 Gene

  • This gene encodes a RUN and SH3 domain containing protein that interacts with Rab1b and Rab1-binding protein GM130. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2012]

GeneCards Summary for RUSC2 Gene

RUSC2 (RUN And SH3 Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is RUSC1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RUSC2 Gene

Genomics for RUSC2 Gene

Genomic Location for RUSC2 Gene

Start:
35,489,838 bp from pter
End:
35,561,898 bp from pter
Size:
72,061 bases
Orientation:
Plus strand

Genomic View for RUSC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RUSC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RUSC2 Gene

Regulatory Elements for RUSC2 Gene

Proteins for RUSC2 Gene

  • Protein details for RUSC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2Y8-RUSC2_HUMAN
    Recommended name:
    Iporin
    Protein Accession:
    Q8N2Y8
    Secondary Accessions:
    • A2RU62
    • A7E2A9
    • O15080
    • Q5W134
    • Q641Q6
    • Q6P1W7

    Protein attributes for RUSC2 Gene

    Size:
    1516 amino acids
    Molecular mass:
    161225 Da
    Quaternary structure:
    • Interacts with active RAB1A and RAB1B, and with GOLGA2.
    SequenceCaution:
    • Sequence=BAA20830.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for RUSC2 Gene

Proteomics data for RUSC2 Gene at MOPED

Post-translational modifications for RUSC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RUSC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RUSC2 Gene

Domains for RUSC2 Gene

Protein Domains for RUSC2 Gene

UniProtKB/Swiss-Prot:

RUSC2_HUMAN
Domain:
  • The RUN domain is required for the interaction with RAB1A and RAB1B:
    • Q8N2Y8
  • Contains 1 RUN domain.:
    • Q8N2Y8
  • Contains 1 SH3 domain.:
    • Q8N2Y8
genes like me logo Genes that share domains with RUSC2: view

No data available for Gene Families for RUSC2 Gene

Function for RUSC2 Gene

Gene Ontology (GO) - Molecular Function for RUSC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15796781
GO:0017137 Rab GTPase binding IPI 15796781
genes like me logo Genes that share ontologies with RUSC2: view
genes like me logo Genes that share phenotypes with RUSC2: view

miRNA for RUSC2 Gene

miRTarBase miRNAs that target RUSC2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RUSC2 Gene

Localization for RUSC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RUSC2 Gene

Cytoplasm, cytosol. Note=Cytosolic punctate distribution. Also observed in the perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RUSC2 Gene COMPARTMENTS Subcellular localization image for RUSC2 gene
Compartment Confidence
cytosol 5
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RUSC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0031410 cytoplasmic vesicle IDA 15796781
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with RUSC2: view

Pathways for RUSC2 Gene

SuperPathways for RUSC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RUSC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with RUSC2: view

No data available for Pathways by source for RUSC2 Gene

Transcripts for RUSC2 Gene

Unigene Clusters for RUSC2 Gene

RUN and SH3 domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RUSC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: - - - - - - - - - - -
SP8:

Relevant External Links for RUSC2 Gene

GeneLoc Exon Structure for
RUSC2
ECgene alternative splicing isoforms for
RUSC2

Expression for RUSC2 Gene

mRNA expression in normal human tissues for RUSC2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RUSC2 Gene

SOURCE GeneReport for Unigene cluster for RUSC2 Gene Hs.493796

mRNA Expression by UniProt/SwissProt for RUSC2 Gene

Q8N2Y8-RUSC2_HUMAN
Tissue specificity: Widely expressed, with highest levels in brain and testis.
genes like me logo Genes that share expressions with RUSC2: view

Orthologs for RUSC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RUSC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RUSC2 36
  • 99.36 (n)
  • 99.25 (a)
RUSC2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RUSC2 36
  • 89.4 (n)
  • 90.66 (a)
RUSC2 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RUSC2 36
  • 90.73 (n)
  • 91.67 (a)
RUSC2 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rusc2 36
  • 85.32 (n)
  • 86.41 (a)
Rusc2 16
Rusc2 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RUSC2 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RUSC2 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rusc2 36
  • 85.83 (n)
  • 87.1 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 25 (a)
OneToMany
-- 37
  • 58 (a)
OneToMany
RUSC2 36
  • 65 (n)
  • 63.51 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 64 (a)
OneToMany
-- 37
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rusc2 36
  • 59.97 (n)
  • 57.05 (a)
zebrafish
(Danio rerio)
Actinopterygii rusc2 36
  • 55.43 (n)
  • 53.8 (a)
rusc2 37
  • 40 (a)
ManyToMany
Species with no ortholog for RUSC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RUSC2 Gene

ENSEMBL:
Gene Tree for RUSC2 (if available)
TreeFam:
Gene Tree for RUSC2 (if available)

Paralogs for RUSC2 Gene

Paralogs for RUSC2 Gene

genes like me logo Genes that share paralogs with RUSC2: view

Variants for RUSC2 Gene

Sequence variations from dbSNP and Humsavar for RUSC2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs717383 -- 35,505,343(-) AAACC(A/C)TGTGC intron-variant
rs717384 -- 35,505,350(-) TTAGA(C/G)AAAAC intron-variant
rs870978 -- 35,556,253(-) CCAGG(C/G)CAGTT intron-variant
rs878072 -- 35,556,324(-) GGTAA(C/T)GGCTT synonymous-codon, reference, nc-transcript-variant
rs946483 -- 35,555,826(+) CTCCC(C/T)CAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RUSC2 Gene

Variant ID Type Subtype PubMed ID
nsv831545 CNV Loss 17160897
dgv8167n71 CNV Gain 21882294
nsv512987 CNV Insertion 21212237
esv1015523 CNV Insertion 17803354
esv1590335 CNV Insertion 17803354
nsv527028 CNV Loss 19592680
nsv528256 CNV Loss 19592680

Relevant External Links for RUSC2 Gene

HapMap Linkage Disequilibrium report
RUSC2

Disorders for RUSC2 Gene

Relevant External Links for RUSC2

Genetic Association Database (GAD)
RUSC2
Human Genome Epidemiology (HuGE) Navigator
RUSC2
genes like me logo Genes that share disorders with RUSC2: view

No data available for UniProtKB/Swiss-Prot for RUSC2 Gene

Publications for RUSC2 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Characterization of RUSC1 and RUSC2 genes in silico. (PMID: 15375525) Katoh M. … Katoh M. (Oncol. Rep. 2004) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Identification and characterization of Iporin as a novel interaction partner for rab1. (PMID: 15796781) Bayer M. … Barnekow A. (BMC Cell Biol. 2005) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for RUSC2 Gene

Sources for RUSC2 Gene

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