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Aliases for RUSC2 Gene

Aliases for RUSC2 Gene

  • RUN And SH3 Domain Containing 2 2 3 5
  • RUN And SH3 Domain-Containing Protein 2 3 4
  • Interacting Protein Of Rab1 3 4
  • KIAA0375 4
  • Iporin 3

External Ids for RUSC2 Gene

Previous GeneCards Identifiers for RUSC2 Gene

  • GC09P035536
  • GC09P035482
  • GC09P035483
  • GC09P035444

Summaries for RUSC2 Gene

Entrez Gene Summary for RUSC2 Gene

  • This gene encodes a RUN and SH3 domain containing protein that interacts with Rab1b and Rab1-binding protein GM130. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2012]

GeneCards Summary for RUSC2 Gene

RUSC2 (RUN And SH3 Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include Rab GTPase binding. An important paralog of this gene is RUSC1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RUSC2 Gene

Genomics for RUSC2 Gene

Regulatory Elements for RUSC2 Gene

Enhancers for RUSC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RUSC2 on UCSC Golden Path with GeneCards custom track

Promoters for RUSC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RUSC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RUSC2 Gene

35,489,838 bp from pter
35,561,898 bp from pter
72,061 bases
Plus strand

Genomic View for RUSC2 Gene

Genes around RUSC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RUSC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RUSC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RUSC2 Gene

Proteins for RUSC2 Gene

  • Protein details for RUSC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A2RU62
    • A7E2A9
    • O15080
    • Q5W134
    • Q641Q6
    • Q6P1W7

    Protein attributes for RUSC2 Gene

    1516 amino acids
    Molecular mass:
    161225 Da
    Quaternary structure:
    • Interacts with active RAB1A and RAB1B, and with GOLGA2.
    • Sequence=BAA20830.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for RUSC2 Gene

Proteomics data for RUSC2 Gene at MOPED

Post-translational modifications for RUSC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RUSC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for RUSC2
  • Santa Cruz Biotechnology (SCBT) Antibodies for RUSC2

No data available for DME Specific Peptides for RUSC2 Gene

Domains & Families for RUSC2 Gene

Protein Domains for RUSC2 Gene

Suggested Antigen Peptide Sequences for RUSC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The RUN domain is required for the interaction with RAB1A and RAB1B.
  • The RUN domain is required for the interaction with RAB1A and RAB1B.
  • Contains 1 RUN domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with RUSC2: view

No data available for Gene Families for RUSC2 Gene

Function for RUSC2 Gene

genes like me logo Genes that share phenotypes with RUSC2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RUSC2 Gene

Localization for RUSC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RUSC2 Gene

Cytoplasm, cytosol. Note=Cytosolic punctate distribution. Also observed in the perinuclear region.

Subcellular locations from

Jensen Localization Image for RUSC2 Gene COMPARTMENTS Subcellular localization image for RUSC2 gene
Compartment Confidence
extracellular 5
cytosol 4
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for RUSC2 Gene

Pathways & Interactions for RUSC2 Gene

SuperPathways for RUSC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RUSC2 Gene


No data available for Pathways by source and SIGNOR curated interactions for RUSC2 Gene

Drugs & Compounds for RUSC2 Gene

No Compound Related Data Available

Transcripts for RUSC2 Gene

Unigene Clusters for RUSC2 Gene

RUN and SH3 domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RUSC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
SP2: -
SP7: - - - - - - - - - - -

Relevant External Links for RUSC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RUSC2 Gene

mRNA expression in normal human tissues for RUSC2 Gene

Protein differential expression in normal tissues from HIPED for RUSC2 Gene

This gene is overexpressed in Bone (20.5), Heart (17.2), Colon muscle (10.2), and Rectum (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RUSC2 Gene

SOURCE GeneReport for Unigene cluster for RUSC2 Gene Hs.493796

mRNA Expression by UniProt/SwissProt for RUSC2 Gene

Tissue specificity: Widely expressed, with highest levels in brain and testis.
genes like me logo Genes that share expression patterns with RUSC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for RUSC2 Gene

Orthologs for RUSC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RUSC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RUSC2 35
  • 89.4 (n)
  • 90.66 (a)
RUSC2 36
  • 90 (a)
(Canis familiaris)
Mammalia RUSC2 35
  • 90.73 (n)
  • 91.67 (a)
RUSC2 36
  • 92 (a)
(Mus musculus)
Mammalia Rusc2 35
  • 85.32 (n)
  • 86.41 (a)
Rusc2 16
Rusc2 36
  • 87 (a)
(Pan troglodytes)
Mammalia RUSC2 35
  • 99.36 (n)
  • 99.25 (a)
RUSC2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rusc2 35
  • 85.83 (n)
  • 87.1 (a)
(Monodelphis domestica)
Mammalia RUSC2 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia RUSC2 36
  • 62 (a)
(Gallus gallus)
Aves RUSC2 35
  • 65 (n)
  • 63.51 (a)
-- 36
  • 25 (a)
-- 36
  • 58 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
-- 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rusc2 35
  • 59.97 (n)
  • 57.05 (a)
(Danio rerio)
Actinopterygii rusc2 35
  • 55.43 (n)
  • 53.8 (a)
rusc2 36
  • 40 (a)
Species with no ortholog for RUSC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RUSC2 Gene

Gene Tree for RUSC2 (if available)
Gene Tree for RUSC2 (if available)

Paralogs for RUSC2 Gene

Paralogs for RUSC2 Gene

genes like me logo Genes that share paralogs with RUSC2: view

Variants for RUSC2 Gene

Sequence variations from dbSNP and Humsavar for RUSC2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1535422 - 35,546,738(+) ACTCT(A/G)CTCCA intron-variant, nc-transcript-variant, reference, missense
rs3750427 - 35,548,482(-) TCCCT(A/G)GGAGA intron-variant, reference, missense
rs717383 -- 35,505,343(-) AAACC(A/C)TGTGC intron-variant
rs717384 -- 35,505,350(-) TTAGA(C/G)AAAAC intron-variant
rs870978 -- 35,556,253(-) CCAGG(C/G)CAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RUSC2 Gene

Variant ID Type Subtype PubMed ID
nsv831545 CNV Loss 17160897
dgv8167n71 CNV Gain 21882294
nsv512987 CNV Insertion 21212237
esv1015523 CNV Insertion 17803354
esv1590335 CNV Insertion 17803354
nsv527028 CNV Loss 19592680
nsv528256 CNV Loss 19592680

Variation tolerance for RUSC2 Gene

Residual Variation Intolerance Score: 1.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RUSC2 Gene

Disorders for RUSC2 Gene

Relevant External Links for RUSC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RUSC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RUSC2 Gene

Publications for RUSC2 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4 67
  2. Characterization of RUSC1 and RUSC2 genes in silico. (PMID: 15375525) Katoh M. … Katoh M. (Oncol. Rep. 2004) 3 23
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  5. Copy number alterations and neoplasia-specific mutations in MELK, PDCD1LG2, TLN1, and PAX5 at 9p in different neoplasias. (PMID: 24664538) Sarhadi V.K. … Knuutila S. (Genes Chromosomes Cancer 2014) 3

Products for RUSC2 Gene

Sources for RUSC2 Gene