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Aliases for RUSC2 Gene

Aliases for RUSC2 Gene

  • RUN And SH3 Domain Containing 2 2 3 5
  • RUN And SH3 Domain-Containing Protein 2 3 4
  • Interacting Protein Of Rab1 3 4
  • KIAA0375 4
  • Iporin 3

External Ids for RUSC2 Gene

Previous GeneCards Identifiers for RUSC2 Gene

  • GC09P035536
  • GC09P035482
  • GC09P035483
  • GC09P035444

Summaries for RUSC2 Gene

Entrez Gene Summary for RUSC2 Gene

  • This gene encodes a RUN and SH3 domain containing protein that interacts with Rab1b and Rab1-binding protein GM130. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2012]

GeneCards Summary for RUSC2 Gene

RUSC2 (RUN And SH3 Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include Rab GTPase binding. An important paralog of this gene is RUSC1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RUSC2 Gene

Genomics for RUSC2 Gene

Regulatory Elements for RUSC2 Gene

Enhancers for RUSC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F035552 1 Ensembl ENCODE 12.3 +63.8 63766 2.7 ARID4B KLF17 SIN3A FEZF1 RAD21 RFX5 RCOR1 MIXL1 ZNF654 CEBPB RUSC2 STOML2 ENSG00000234181 PIGO OR13J1 ENSG00000227388 PIR61372 FAM166B
GH09F035533 1.1 Ensembl ENCODE 11.9 +43.7 43663 1.0 CEBPB RUSC2 FAM166B PIR61372 RPL36AP33
GH09F035531 0.2 Ensembl 11.9 +41.8 41815 0.6 SPI1 RUSC2 PIR61372 RPL36AP33
GH09F035537 0.7 ENCODE 11.7 +48.7 48693 2.9 JUND SMARCA4 POLR2A BHLHE40 CTBP2 REST FAM166B RUSC2 OR13J1 PIR61372 RPL36AP33
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RUSC2 on UCSC Golden Path with GeneCards custom track

Promoters for RUSC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001908559 762 2801 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 SP3 ZHX2 MXD4

Genomic Location for RUSC2 Gene

35,489,838 bp from pter
35,561,898 bp from pter
72,061 bases
Plus strand

Genomic View for RUSC2 Gene

Genes around RUSC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RUSC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RUSC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RUSC2 Gene

Proteins for RUSC2 Gene

  • Protein details for RUSC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A2RU62
    • A7E2A9
    • O15080
    • Q5W134
    • Q641Q6
    • Q6P1W7

    Protein attributes for RUSC2 Gene

    1516 amino acids
    Molecular mass:
    161225 Da
    Quaternary structure:
    • Interacts with active RAB1A and RAB1B, and with GOLGA2.
    • Sequence=BAA20830.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for RUSC2 Gene

Post-translational modifications for RUSC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RUSC2 Gene

No data available for DME Specific Peptides for RUSC2 Gene

Domains & Families for RUSC2 Gene

Protein Domains for RUSC2 Gene

Suggested Antigen Peptide Sequences for RUSC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The RUN domain is required for the interaction with RAB1A and RAB1B.
  • The RUN domain is required for the interaction with RAB1A and RAB1B.
  • Contains 1 RUN domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with RUSC2: view

No data available for Gene Families for RUSC2 Gene

Function for RUSC2 Gene

Gene Ontology (GO) - Molecular Function for RUSC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15796781
GO:0017137 Rab GTPase binding IPI 15796781
genes like me logo Genes that share ontologies with RUSC2: view
genes like me logo Genes that share phenotypes with RUSC2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RUSC2 Gene

Localization for RUSC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RUSC2 Gene

Cytoplasm, cytosol. Note=Cytosolic punctate distribution. Also observed in the perinuclear region.

Subcellular locations from

Jensen Localization Image for RUSC2 Gene COMPARTMENTS Subcellular localization image for RUSC2 gene
Compartment Confidence
extracellular 5
cytosol 4
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RUSC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
GO:0031410 cytoplasmic vesicle IDA 15796781
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with RUSC2: view

Pathways & Interactions for RUSC2 Gene

SuperPathways for RUSC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RUSC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with RUSC2: view

No data available for Pathways by source and SIGNOR curated interactions for RUSC2 Gene

Transcripts for RUSC2 Gene

Unigene Clusters for RUSC2 Gene

RUN and SH3 domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RUSC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
SP2: -
SP7: - - - - - - - - - - -

Relevant External Links for RUSC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RUSC2 Gene

mRNA expression in normal human tissues for RUSC2 Gene

Protein differential expression in normal tissues from HIPED for RUSC2 Gene

This gene is overexpressed in Bone (20.5), Heart (17.2), Colon muscle (10.2), and Rectum (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RUSC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RUSC2 Gene:


SOURCE GeneReport for Unigene cluster for RUSC2 Gene:


mRNA Expression by UniProt/SwissProt for RUSC2 Gene:

Tissue specificity: Widely expressed, with highest levels in brain and testis.
genes like me logo Genes that share expression patterns with RUSC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for RUSC2 Gene

Orthologs for RUSC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RUSC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RUSC2 34 35
  • 99.36 (n)
(Canis familiaris)
Mammalia RUSC2 34 35
  • 90.73 (n)
(Bos Taurus)
Mammalia RUSC2 34 35
  • 89.4 (n)
(Rattus norvegicus)
Mammalia Rusc2 34
  • 85.83 (n)
(Mus musculus)
Mammalia Rusc2 34 16 35
  • 85.32 (n)
(Monodelphis domestica)
Mammalia RUSC2 35
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia RUSC2 35
  • 62 (a)
(Gallus gallus)
Aves RUSC2 34
  • 65 (n)
-- 35
  • 58 (a)
-- 35
  • 25 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 64 (a)
-- 35
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rusc2 34
  • 59.97 (n)
(Danio rerio)
Actinopterygii rusc2 34 35
  • 55.43 (n)
Species where no ortholog for RUSC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RUSC2 Gene

Gene Tree for RUSC2 (if available)
Gene Tree for RUSC2 (if available)

Paralogs for RUSC2 Gene

Paralogs for RUSC2 Gene

genes like me logo Genes that share paralogs with RUSC2: view

Variants for RUSC2 Gene

Sequence variations from dbSNP and Humsavar for RUSC2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10283553 -- 35,486,435(+) GTAAC(A/G)TGGCA upstream-variant-2KB
rs10283924 -- 35,486,356(+) gctca(C/T)gtctg upstream-variant-2KB
rs10453174 -- 35,495,359(+) aagat(A/G)agggt intron-variant
rs1046415 -- 35,561,630(+) TGGCC(C/T)GTCTG intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1046419 -- 35,561,633(+) CCCGT(C/T)TGGGC intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RUSC2 Gene

Variant ID Type Subtype PubMed ID
esv1015523 CNV insertion 17803354
esv1590335 CNV insertion 17803354
esv3325098 CNV duplication 20981092
esv3620378 CNV gain 21293372
esv3620379 CNV gain 21293372
nsv1030303 CNV gain 25217958
nsv1125318 OTHER inversion 24896259
nsv512987 CNV insertion 21212237
nsv527028 CNV loss 19592680
nsv528256 CNV loss 19592680
nsv614163 CNV loss 21841781
nsv831545 CNV loss 17160897
nsv951701 CNV deletion 24416366
nsv968610 CNV duplication 23825009

Variation tolerance for RUSC2 Gene

Residual Variation Intolerance Score: 1.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RUSC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RUSC2 Gene

Disorders for RUSC2 Gene

Relevant External Links for RUSC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RUSC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RUSC2 Gene

Publications for RUSC2 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. Identification and characterization of Iporin as a novel interaction partner for rab1. (PMID: 15796781) Bayer M. … Barnekow A. (BMC Cell Biol. 2005) 3 4 64
  4. Characterization of RUSC1 and RUSC2 genes in silico. (PMID: 15375525) Katoh M. … Katoh M. (Oncol. Rep. 2004) 3 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for RUSC2 Gene

Sources for RUSC2 Gene

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