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RUSC1 Gene

protein-coding   GIFtS: 52
GCID: GC01P155290

RUN And SH3 Domain Containing 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RUN And SH3 Domain Containing 11 2
New Molecule Containing SH3 At The Carboxy-Terminus2 3
NESCA2 3
RUN And SH3 Domain-Containing Protein 12
Nesca3

External Ids:    HGNC: 171531   Entrez Gene: 236232   Ensembl: ENSG000001607537   UniProtKB: Q9BVN23   

Export aliases for RUSC1 gene to outside databases

Previous GC identifers: GC01P151031 GC01P152068 GC01P152507 GC01P152511 GC01P152103 GC01P153557 GC01P126652


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RUSC1 Gene:
RUSC1 (RUN and SH3 domain containing 1) is a protein-coding gene. GO annotations related to this gene include SH3/SH2 adaptor activity and actin binding. An important paralog of this gene is RUSC2.

UniProtKB/Swiss-Prot: RUSC1_HUMAN, Q9BVN2
Function: Putative signaling adapter which may play a role in neuronal differentiation. May be involved in
regulation of NGF-dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking,
specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are
regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be
involved in regulation of the NF-kappa-B pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RUSC1 gene promoter:
         IRF-7A   SEF-1 (1)   GATA-1   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRUSC1 promoter sequence
   Search Chromatin IP Primers for RUSC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RUSC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q21-q22

RUSC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RUSC1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P155290:  view genomic region     (about GC identifiers)

Start:
155,290,640 bp from pter      End:
155,300,909 bp from pter
Size:
10,270 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RUSC1_HUMAN, Q9BVN2 (See protein sequence)
Recommended Name: RUN and SH3 domain-containing protein 1  
Size: 902 amino acids; 96444 Da
Subunit: Interacts with IKBKG and TRAF6. Interacts with F-actin, acetylated actin, TUBB3, STX1A, KIF5B and KLC1
(By similarity)
Sequence caution: Sequence=CAI12719.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for RUSC1:
4GIW (3D)    
Secondary accessions: Q5T9U9 Q5T9V1 Q5T9V2 Q9UPY4 Q9Y4T5
Alternative splicing: 2 isoforms:  Q9BVN2-1   Q9BVN2-2   

Explore the universe of human proteins at neXtProt for RUSC1: NX_Q9BVN2

Explore proteomics data for RUSC1 at MOPED

Post-translational modifications: 

  • Phosphorylated on serine residues following nuclear translocation1
  • Polyubiquitinated; polyubiquitination involves TRAF61
  • Ubiquitination2 at Lys803
  • Modification sites at PhosphoSitePlus

  • See RUSC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001098673.1  NP_001098674.1  NP_001098675.1  NP_001265156.1  NP_001265157.1  NP_001265158.1  NP_001265159.1  NP_055143.2  

    ENSEMBL proteins: 
     ENSP00000357338   ENSP00000357336   ENSP00000357331   ENSP00000357333   ENSP00000292254  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001452 SH3_domain
     IPR004012 Run

    Graphical View of Domain Structure for InterPro Entry Q9BVN2

    ProtoNet protein and cluster: Q9BVN2

    1 Blocks protein domain: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: RUSC1_HUMAN, Q9BVN2
    Domain: The RUN domain is necessary for NGF induced nuclear redistribution
    Similarity: Contains 1 RUN domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with RUSC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RUSC1_HUMAN, Q9BVN2
    Function: Putative signaling adapter which may play a role in neuronal differentiation. May be involved in
    regulation of NGF-dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking,
    specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are
    regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be
    involved in regulation of the NF-kappa-B pathway

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding ISS--
    GO:0005070SH3/SH2 adaptor activity TAS10760598
    GO:0005515protein binding IPI19365808
         
    Find genes that share ontologies with RUSC1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RUSC1

    miRNA
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    hsa-mir-7-5p (MIRT025953), hsa-mir-425-5p (MIRT039308), hsa-mir-193b-3p (MIRT016602)

    Block miRNA regulation of human, mouse, rat RUSC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RUSC1 (see all 11):
    hsa-miR-140-3p hsa-miR-600 hsa-miR-125a-3p hsa-miR-3065-3p hsa-miR-2278 hsa-miR-455-3p hsa-miR-4314 hsa-miR-4298
    SwitchGear 3'UTR luciferase reporter plasmidRUSC1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RUSC1_HUMAN, Q9BVN2: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton (By similarity). Cytoplasmic vesicle (By
    similarity). Early endosome (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic
    density (By similarity). Golgi apparatus (By similarity). Note=Translocated to the nuclear envelope upon
    stimulation with NGF. Associated with membranes and microtubules (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol4
    endosome4
    golgi apparatus4
    plasma membrane3
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005769early endosome ISS--
    GO:0005794Golgi apparatus ISS--
    GO:0005874microtubule IEA--

    Find genes that share ontologies with RUSC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RUSC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Trk receptor signaling mediated by the MAPK pathway
    Trk receptor signaling mediated by the MAPK pathway


    1 BioSystems Pathway for RUSC1
        Trk receptor signaling mediated by the MAPK pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RUSC1
    Interactions:

        Search GeneGlobe Interaction Network for RUSC1

    5 Interacting proteins for RUSC1 (Q9BVN21, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKGQ9Y6K91, 3EBI-6257338,EBI-81279 I2D: score=2 
    TRAF6Q9Y4K31, 3EBI-6257338,EBI-359276 I2D: score=2 
    DVL2O146413I2D: score=1 
    NTRK1P046293I2D: score=1 
    UBCP0CG483I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA19365808
    GO:0009967positive regulation of signal transduction TAS10760598

    Find genes that share ontologies with RUSC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RUSC1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RUSC1 gene (8 alternative transcripts): 
    NM_001105203.1  NM_001105204.1  NM_001105205.1  NM_001278227.1  NM_001278228.1  NM_001278229.1  NM_001278230.1  NM_014328.4  

    Unigene Cluster for RUSC1:

    RUN and SH3 domain containing 1
    Hs.226499  [show with all ESTs]
    Unigene Representative Sequence: NM_001105203
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368354(uc001fkk.2) ENST00000368352(uc001fkj.2) ENST00000467820
    ENST00000484664 ENST00000497930 ENST00000368347(uc001fkl.2 uc001fkp.2 uc010pgb.1 uc009wqp.1)
    ENST00000489860 ENST00000462780 ENST00000368349 ENST00000492536 ENST00000490373
    ENST00000479924 ENST00000468764 ENST00000471876(uc001fko.2) ENST00000292254(uc009wqo.1 uc001fkn.2 uc001fkr.2)
    ENST00000473331 ENST00000485924
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    hsa-miR-140-3p hsa-miR-600 hsa-miR-125a-3p hsa-miR-3065-3p hsa-miR-2278 hsa-miR-455-3p hsa-miR-4314 hsa-miR-4298
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      QuantiTect SYBR Green Assays in human, mouse, rat RUSC1
      QuantiFast Probe-based Assays in human, mouse, rat RUSC1

    Additional mRNA sequence: 

    AB026894.2 AK055451.1 AK074485.1 AK074982.1 AK125378.1 AK298730.1 AK307736.1 AK314559.1 
    AL080083.1 BC001045.2 BC004293.1 BC025680.1 BC028055.1 BC052277.1 BC131492.1 BX640612.1 
    CR749671.1 

    Selected DOTS entries (see all 34):

    DT.97849204  DT.95114937  DT.100881316  DT.100775646  DT.454177  DT.100765334  DT.100881314  DT.100881322 
    DT.121365214  DT.91916772  DT.121365180  DT.100881328  DT.100775644  DT.91763994  DT.100742144  DT.100689180 
    DT.100881319  DT.121365044  DT.100733135  DT.100833647  DT.100835809  DT.121365166  DT.99998848  DT.100666619 

    Selected AceView cDNA sequences (see all 178):

    BX387416 BI770166 BM547311 AA405803 AA666060 CA397403 CA495388 BX380825 
    CA449132 CR603309 CA455157 CD625556 CR604047 CR618456 BC052277 CB242736 
    AK093777 CR749671 AW183138 BM695809 BX402179 AW516552 AW137077 BC004293 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RUSC1 (see all 22)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e ^ 13a ·
    SP1:              -     -     -     -     -     -     -     -     -     -                 -                                                                     
    SP2:                                                              -     -                 -                                                                     
    SP3:                                                                    -                 -                                                                     
    SP4:                                                                          -           -                                   -     -     -     -     -         
    SP5:                                                                          -           -                                                                     

    ExUns: 13b ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for RUSC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RUSC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTACTAGG
    RUSC1 Expression
    About this image


    RUSC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    RUSC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RUSC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.226499

    UniProtKB/Swiss-Prot: RUSC1_HUMAN, Q9BVN2
    Tissue specificity: Predominantly expressed in brain

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUSC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RUSC1 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rusc11 , 5 RUN and SH3 domain containing 11, 5 84.09(n)1
    85.21(a)1
      3 (39.01 cM)5
    722961  NM_028188.21  NP_082464.21 
     890839815 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.35372 Xenopus laevis transcribed sequence with weak similarity more 75.29(n)    BX842920.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rusc16
    RUN and SH3 domain containing 1
    12(a)
    1 ↔ 1
    16(15791468-15824231) ENSDARG00000078125


    ENSEMBL Gene Tree for RUSC1 (if available)
    TreeFam Gene Tree for RUSC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RUSC1 gene
    RUSC22  
    1 SIMAP similar gene for RUSC1 using alignment to 2 protein entries:     RUSC1_HUMAN (see all proteins):
    DKFZp761A1822

    Find genes that share paralogs with RUSC1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RUSC1 (see all 225)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1999128371,2
    C--155301098(+) GTTAG-/TTAG  
            
    ACTAA
    2 -- int10--------
    rs3726514981,2
    C--161792646(+) GCAGTC/GCACCC 1 -- us2k10--------
    rs2015397011,2
    C--161792685(+) CTGTGC/TCCTGC 1 -- us2k10--------
    rs412649411,2
    C--161792690(+) CCCTGC/TCGGTG 1 -- us2k10--------
    rs2003696331,2
    --161792698(+) GTGCTG/TCCAGG 1 -- us2k10--------
    rs1488953701,2
    C--161792817(+) TTAGCC/GCCGAT 1 -- us2k10--------
    rs741184451,2
    C,F--161792988(+) GAGCTG/TCTTCT 1 -- us2k12Minor allele frequency- T:0.50WA CSA 4
    rs1995627621,2
    --161793246(+) GTTGGA/GAAAAC 2 -- us2k10--------
    rs2017421311,2
    --161793421(+) CACGTC/GCTTCC 2 -- us2k10--------
    rs1923100771,2
    --161793471(+) CCCTTA/GTCCCG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for RUSC1 (155290640 - 155300909 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RUSC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3n68CNV Loss17160897
    nsv872457CNV Loss21882294
    nsv831636CNV Loss17160897
    esv33869CNV Loss17666407
    dgv132e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RUSC1
    DNA2.0 Custom Variant and Variant Library Synthesis for RUSC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RUSC1 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with RUSC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel human gene (NESCA) which encodes a putative adapter protein containing SH3. (PubMed id 10760598)1, 2, 3 Matsuda S.... Hamaguchi M. (Biochim. Biophys. Acta 2000)
    2. Nesca, a novel adapter, translocates to the nuclear envelope and regulates neurotrophin-induced neurite outgrowth. (PubMed id 15024033)1, 2, 9 MacDonald J.I.S.... Meakin S.O. (J. Cell Biol. 2004)
    3. NESCA: a new NEMO/IKKgamma and TRAF6 interacting protein. (PubMed id 19365808)1, 2 Napolitano G....Ursini M.V. (J. Cell. Physiol. 2009)
    4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Nesca, a novel neuronal adapter protein, links the molecular motor kinesin with the pre-synaptic membrane protein, syntaxin-1, in hippocampal neurons. (PubMed id 22404429)1 MacDonald J.I....Meakin S.O. (J. Neurochem. 2012)
    8. Crystal structure and functional implication of the RUN domain of human NESCA. (PubMed id 22821014)1 Sun Q....Jiang T. (amp 2012)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23623 HGNC: 17153 AceView: RUSC1 Ensembl:ENSG00000160753 euGenes: HUgn23623
    ECgene: RUSC1 H-InvDB: RUSC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RUSC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RUSC1 gene:
    Search GeneIP for patents involving RUSC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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