Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RUNX3 Gene

protein-coding   GIFtS: 67
GCID: GC01M025226

runt-related transcription factor 3


(Previous symbol: CBFA3)
 Explore 61 diseases affiliated with
RUNX3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RUNX3    

Aliases
for RUNX3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Runt-Related Transcription Factor 31 2     PEBP2-Alpha C2 3
AML21 2 3 5     SL3-3 Enhancer Factor 1 Alpha C Subunit2 3
CBFA31 2 3 5     SL3/AKV Core-Binding Factor Alpha C Subunit2 3
PEBP2A31 3 5     PEBP2aC2
Acute Myeloid Leukemia 2 Protein2 3     Acute Myeloid Leukemia Gene 22
Core-Binding Factor Subunit Alpha-32 3     Core-Binding Factor, Runt Domain, Alpha Subunit 32
Oncogene AML-22 3     PEA2 Alpha C2
Polyomavirus Enhancer-Binding Protein 2 Alpha C Subunit2 3     PEBP2 Alpha C2
CBF-Alpha-31     Transcription Factor AML22
PEA2-Alpha C2 3     

External Ids:    HGNC: 104731   Entrez Gene: 8642   Ensembl: ENSG000000206337   OMIM: 6002105   UniProtKB: Q137613   
ORGUL members:         
NONCODE:n337779    

Export aliases for RUNX3 gene to outside databases

Previous GC identifers: GC01M024749 GC01M024294 GC01M024205 GC01M024577 GC01M024971 GC01M025098 GC01M023479


Summaries
for RUNX3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RUNX3:
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein
and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers
and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors.
It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer.
Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RUNX3_HUMAN, Q13761
Function: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia
virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters

Gene Wiki entry for RUNX3


Genomic Views
for RUNX3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RUNX3 gene promoter:
         STAT1   STAT2   p300   STAT1beta   STAT3   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RUNX3 promoter sequence
   Search SABiosciences Chromatin IP Primers for RUNX3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RUNX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36

RUNX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RUNX3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M025226:  view genomic region     (about GC identifiers)

Start:
 25,226,002 bp from pter      End:
 25,291,612 bp from pter
Size:
 65,611 bases      Orientation:
 minus strand

Proteins
for RUNX3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RUNX3_HUMAN, Q13761 (See protein sequence)
Recommended Name: Runt-related transcription factor 3  
Size: 415 amino acids; 44356 Da
Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt
domain. DNA-binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1. The tyrosine phosphorylated
form (via runt domain) interacts with SRC (via protein kinase domain). Interacts with FYN and LCK
Subcellular location: Nucleus. Cytoplasm. Note=The tyrosine phosphorylated form localizes to the cytoplasm
Secondary accessions: B1AJV5 Q12969 Q13760
Alternative splicing: 2 isoforms:  Q13761-1   Q13761-2   

Explore the universe of human proteins at neXtProt for RUNX3: NX_Q13761

Post-translational modifications:

  • Phosphorylated on tyrosine residues by SRC. Phosphorylated by LCK and FYN1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13761

    • RUNX3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001026850.1  NP_004341.1  

    ENSEMBL proteins: 
     ENSP00000308051   ENSP00000343477   ENSP00000382800   ENSP00000444872  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: RUNX3
    OriGene Custom Protein Services for RUNX3 
    GenScript Custom Purified and Recombinant Proteins Services for RUNX3
    Novus Biologicals RUNX3 Proteins
    Novus Biologicals RUNX3 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for RUNX3
    Uscn Proteins for RUNX3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin ISS--
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--


    RUNX3 for ontologies           About GeneDecksing



    RUNX3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RUNX3
    R&D Systems Antibodies for RUNX3 (RUNX3/CBFA3)
    Cell Signaling Technology (CST) Antibodies for RUNX3  (AML2)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RUNX3 
    GenScript Superior Antibodies for RUNX3
    Novus Biologicals RUNX3 Antibodies
    Search for Antibodies for RUNX3 at Abcam  
    Uscn Antibodies for RUNX3
    ThermoFisher Antibody for RUNX3

    Assay Products for RUNX3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RUNX3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RUNX3

    Protein Domains /
    Families
    for RUNX3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RUNX3 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR012346 p53/RUNT-type_TF_DNA-bd
     IPR000040 AML1_Runt
     IPR008967 p53-like_TF_DNA-bd
     IPR016554 TF_Runt-rel_RUNX
     IPR013711 RunxI

    Graphical View of Domain Structure for InterPro Entry Q13761

    ProtoNet protein and cluster: Q13761

    2 Blocks protein families:
    IPB000040 Acute myeloid leukemia 1 protein signature
    IPB013711 Runx inhibition


    UniProtKB/Swiss-Prot: RUNX3_HUMAN, Q13761
    Domain: A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target
    genes
    Similarity: Contains 1 Runt domain


    Function
    for RUNX3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RUNX3_HUMAN, Q13761
    Function: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia
    virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters

         Genatlas biochemistry entry for RUNX3:
    Drosophila Runt pair rule-related transcription factor 3,expressed in various lymphoid and myeloid cells,involved in
    hematopoiesis and osteogenesis

    miRNA
    Products:            		miRTarBase miRNAs that target RUNX3:
    hsa-mir-130b (MIRT003316), hsa-mir-532-5p (MIRT000038)

    OriGene 3'-UTR Clone (see all 2): RUNX3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RUNX3
    8/67 QIAGEN miScript miRNA Assays for microRNAs that regulate RUNX3 (see all 67):
    hsa-miR-520e hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-637 hsa-miR-130b hsa-miR-520b hsa-miR-20a
    SwitchGear 3'UTR luciferase reporter plasmid: RUNX3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RUNX3 (see all 7)
    OriGene shRNA RFP: RUNX3
    OriGene siRNA: RUNX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RUNX3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RUNX3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RUNX3 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RUNX3 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): RUNX3 (NM_004350)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RUNX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUNX3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RUNX3
    Search LifeMap BioReagents cell lines for RUNX3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUNX3

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding ISS--
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity ISS--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity TAS7607690
    GO:0005515protein binding IPI18772112


    RUNX3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RUNX3:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Runx3tm2Yg for RUNX3
         15/16 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Runx3) (see all 16):
     adipose tissue  behavior/neurological  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  integument 
     mortality/aging  muscle  nervous system  no phenotypic analysis  respiratory system 

    RUNX3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RUNX3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TGF-beta/Smad Signaling
    		TGF-beta/Smad Signaling1.00
    2SIDS Susceptibility Pathways
    		SIDS Susceptibility Pathways1.00
    3TGF Beta Signaling Pathway
    		TGF Beta Signaling Pathway1.00
    4TGF-beta Signaling Pathways
    		TGF-beta Signaling Pathways1.00
    5Endochondral Ossification
    		Endochondral Ossification1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 R&D Systems Pathway for RUNX3
        TGF-beta Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for RUNX3
        TGF-beta/Smad Signaling

    3 BioSystems Pathways for RUNX3 
        TGF Beta Signaling Pathway
    SIDS Susceptibility Pathways
    Endochondral Ossification



    RUNX3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RUNX3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for RUNX3 (Q137611, 2, 3 ENSP000003434774) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTNNB1P352221, 3, ENSP000003444564EBI-1046821,EBI-491549 I2D: score=1 STRING: ENSP00000344456
    TCF7L2Q9NQB01, 3, ENSP000003584044EBI-1046821,EBI-924724 I2D: score=1 STRING: ENSP00000358404
    TLE1Q047241, 3, ENSP000003656824EBI-1046821,EBI-711424 I2D: score=5 STRING: ENSP00000365682
    SMAD3P840223, ENSP000003329734I2D: score=3 STRING: ENSP00000332973
    HDAC4P565243, ENSP000002646064I2D: score=2 STRING: ENSP00000264606
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0006355regulation of transcription, DNA-dependent NAS7622058
    GO:0006366transcription from RNA polymerase II promoter TAS7607690
    GO:0006468protein phosphorylation IDA--
    GO:0006917induction of apoptosis ISS--


    RUNX3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RUNX3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RUNX3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RUNX3
    5 Novoseek chemical compound relationships for RUNX3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 76.1 14 15386381 (1), 16328045 (1), 18848767 (1), 17384682 (1) (see all 11)
    oligonucleotide 0 1 16367903 (1)
    serine 0 1 10419474 (1)
    retinoic acid 0 10 10419474 (5), 17270239 (1)
    vegf 0 5 17085650 (5)

    Search CenterWatch for drugs/clinical trials and news about RUNX3 

    Transcripts
    for RUNX3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RUNX3 gene (2 alternative transcripts): 
    NM_001031680.2  NM_004350.2  

    Unigene Cluster for RUNX3:

    Runt-related transcription factor 3
    Hs.170019  [show with all ESTs]
    Unigene Representative Sequence: NM_001031680
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308873(uc001bjq.3 uc010oen.2) ENST00000338888(uc009vrl.1)
    ENST00000496967 ENST00000479341 ENST00000399916(uc009vrj.3 uc001bjr.3 uc009vrk.3)
    ENST00000540420

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): RUNX3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RUNX3
    8/67 QIAGEN miScript miRNA Assays for microRNAs that regulate RUNX3 (see all 67):
    hsa-miR-520e hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-637 hsa-miR-130b hsa-miR-520b hsa-miR-20a
    SwitchGear 3'UTR luciferase reporter plasmid: RUNX3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RUNX3 (see all 7)
    OriGene shRNA RFP: RUNX3
    OriGene siRNA: RUNX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RUNX3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RUNX3 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RUNX3 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): RUNX3 (NM_004350)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RUNX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUNX3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RUNX3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RUNX3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RUNX3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RUNX3

    Additional cDNA sequence: 

    AF022726.2 AJ001432.1 AK091829.1 AK300056.1 AK301044.1 AK310945.1 BC013362.2 EF491807.1 
    EF491822.1 X79550.2 Z35278.1 

    10 DOTS entries:

    DT.316245  DT.121417079  DT.95272569  DT.121417078  DT.91761550  DT.99935616  DT.91641553  DT.101962196 
    DT.121417056  DT.86852679 

    24/168 AceView cDNA sequences (see all 168):

    BX107980 AI633590 AI685772 AW304478 CR591302 AI248006 AI524028 AA312733 
    W94743 BQ708535 CA432310 AW276069 BC013362 AF022726 AA912790 BQ054373 
    BF478062 AI075058 AI131365 BI908613 BM705361 BQ054372 AA302999 AI092506 

    GeneLoc Exon Structure


    Expression
    for RUNX3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RUNX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGAGGTGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RUNX3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/28 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 28) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneAutopod Epiphyseal EndChondrocytesBone, Cartilage
    BoneAutopod Growth PlatePrehypertrophic ChondrocytesBone, Cartilage
    BoneCaudal Endochondral BonesHypertrophic ChondrocytesBone, Cartilage
    BoneCaudal Endochondral BonesPrehypertrophic ChondrocytesBone, Cartilage
    BoneCervical VertebraeChondrocytesBone, Cartilage
    BoneCervical VertebraePrehypertrophic ChondrocytesBone, Cartilage
    BoneEndochondral Facial BonesHypertrophic ChondrocytesBone, Cartilage
    BoneEndochondral Facial BonesPrehypertrophic ChondrocytesBone, Cartilage
    BoneLumbar VertebraeChondrocytesBone, Cartilage
    BoneLumbar VertebraePrehypertrophic ChondrocytesBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 8 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    HyStem+BMP4-induced E15 cells (HyStem+BMP4 inductio...)Adipose, Bone, Cartilage

    See RUNX3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RUNX3

    SOURCE GeneReport for Unigene cluster: Hs.170019
        SABiosciences Expression via Pathway-Focused PCR Arrays including RUNX3: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Leukemia in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              Liver Cancer in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RUNX3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RUNX3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RUNX3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RUNX3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUNX3

    Orthologs
    for RUNX3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RUNX3 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RUNX31 runt-related transcription factor 3 80.81(n)
    88.38(a)    		   769687  XM_001232977.2  XP_001232978.2 
    lizard
    (Anolis carolinensis)    		 Reptilia RUNX36
    		 --
    		 68(a)
    		 1 ↔ 1
    		 GL343464.1(6005-52673)
    zebrafish
    (Danio rerio)    		 Actinopterygii AB043788.12   -- 76.94(n)   58127  AB043788.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG13793 transcription factor 73(a)
    (best of 4)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea rnt-16
    		 RuNT related family member (rnt-1)
    		 28(a)
    		 1 → many
    		 I(5776157-5788612)


    ENSEMBL Gene Tree for RUNX3 (if available)
    TreeFam Gene Tree for RUNX3 (if available) 

    Paralogs
    for RUNX3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RUNX3 gene
    RUNX12  RUNX22  
    6 SIMAP similar genes for RUNX3 using alignment to 2 protein entries:     RUNX3_HUMAN (see all proteins):
    AML2    RUNX1/C20orf112 fusion    RUNX1    RUNX2    RUNX1/CBFA2T2 fusion    C20orf112/RUNX1 fusion

    RUNX3 for paralogs           About GeneDecksing



    Genomic Variants
    for RUNX3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1021 NCBI SNPs in RUNX3 are shown (see all 1021)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs75143321,2
    		C,F,A,H,--25225675(+) CTCCCG/CAAATG 2 -- ds500115Minor allele frequency- C:0.22NS EA WA NA CSA 1202
    rs1158542881,2
    		--25225680(+) GAAATG/CTGAAT 2 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1909602441,2
    		--25225777(+) GAAGAC/TCTATT 2 -- ds50010--------
    rs1821096711,2
    		--25225856(+) TCTGCA/GGCCAT 2 -- ds50010--------
    rs1876009261,2
    		C,--25225929(+) GGCAAA/CAGCAG 2 -- ds50010--------
    rs1449151861,2
    		--25225933(+) ACAGC-/AGGAGGTC 2 -- ds50010--------
    rs1459018541,2
    		--25225953(+) TCTCCC/TCCACC 2 -- ds50010--------
    rs1928335311,2
    		--25225990(+) GAAACC/TGGGCA 2 -- ds50010--------
    rs1383565451,2
    		--25226078(+) CAGAAA/GACAGT 2 -- ut310--------
    rs1488368861,2
    		--25226106(+) TGTGCA/GTTAAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for RUNX3 (25226002 - 25291612 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for RUNX3
         2 Indels: 74413 84138
    Human Gene Mutation Database (HGMD): RUNX3

    SABiosciences Cancer Mutation PCR Assays
    2 SABiosciences qBiomarker Copy Number PCR Arrays containing RUNX3:
    Oncogenes & Tumor Suppressor Genes 384HC
    Pancreatic Cancer
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RUNX3
    DNA2.0 Custom Variant and Variant Library Synthesis for RUNX3

    Disorders / Diseases
    for RUNX3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RUNX3 for disorders           About GeneDecksing

    OMIM gene information: 600210    OMIM disorders: --

    20/61 diseases for RUNX3 (see all 61):    About MalaCards
    acute myeloid leukemia    myeloid leukemia    testicular yolk sac tumor    cleidocranial dysplasia
    leukemia    squamous cell carcinoma    irritable bowel syndrome    biliary tract cancer
    barrett's esophagus    adenoid cystic carcinoma    oral squamous cell carcinoma    esophageal squamous cell carcinoma
    inflammatory bowel disease    papillary thyroid carcinoma    basal cell carcinoma    intrahepatic cholangiocarcinoma
    epithelial ovarian cancer    ulcerative colitis    mucoepidermoid carcinoma    adenoiditis

    3 diseases from the University of Copenhagen DISEASES database for RUNX3:
    Cleidocranial dysplasia     Colorectal cancer     Carcinoma

    10/28 Novoseek disease relationships for RUNX3 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    microsatellite instability 81.1 6 15386381 (1), 19470733 (1), 19789368 (1), 19117505 (1) (see all 5)
    gastric cancer 75.4 163 17085650 (7), 15386419 (6), 16140942 (6), 19290488 (6) (see all 49)
    colorectal cancer 66.8 51 16080503 (5), 19223906 (3), 15273736 (3), 17270239 (3) (see all 20)
    tumors 59.8 174 19336521 (6), 20348954 (5), 15386381 (4), 18410404 (4) (see all 83)
    gastric tumor 58.5 7 18772112 (1), 20490322 (1), 20353948 (1), 20492341 (1) (see all 7)
    gastric carcinoma 56.9 31 15051926 (6), 20485621 (4), 17956589 (3), 14968123 (3) (see all 10)
    colon cancer 54.8 24 15386381 (7), 18949360 (6), 18772112 (1), 14968123 (1) (see all 6)
    cancer 54.7 71 17914577 (3), 18639281 (3), 14968123 (3), 18430739 (3) (see all 39)
    leukemogenesis 48.6 2 12370805 (1), 12682904 (1)
    cleidocranial dysplasia 46.4 1 15138260 (1)

    Human Genome Epidemiology (HuGE) Navigator: RUNX3 (17 documents)

    Export disorders for RUNX3 gene to outside databases

    Publications
    for RUNX3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RUNX3 gene, integrated from 9 sources (see all 330):
    (articles sorted by number of sources associating them with RUNX3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. AML1, AML2, and AML3, the human members of the runt domain gene- family: cDNA structure, expression, and chromosomal localization. (PubMed id 7835892)1, 2, 3 Levanon D.... Groner Y. (1994)
    2. Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm. (PubMed id 20100835)1, 2, 9 Goh Y.M....Bae S.C. (2010)
    3. RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription. (PubMed id 16652147)1, 2 Reed-Inderbitzin E.... Hiebert S.W. (2006)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. (PubMed id 9751710)1, 2 Levanon D.... Groner Y. (1998)
    7. Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog, CBFA3, to chromosome 1p35- pter. (PubMed id 7607690)1, 2 Wijmenga C....Collins F.S. (1995)
    8. Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain. (PubMed id 7622058)1, 2 Bae S.-C.... Ito Y. (1995)
    9. Expression of RUNX3 gene, methylation status and clinicopathological significance in breast cancer and breast cancer cell lines. (PubMed id 18580070)1, 9 Jiang Y....Geng J. (2008)
    10. Regulation of RUNX3 tumor suppressor gene expression in cutaneous melanoma. (PubMed id 19336521)1, 9 Kitago M....Hoon D.S. (2009)

    External Searches for RUNX3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RUNX3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 864 HGNC: 10473 AceView: RUNX3 Ensembl:ENSG00000020633 euGenes: HUgn864
    ECgene: RUNX3 H-InvDB: RUNX3

    Other Databases showing RUNX3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RUNX3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RUNX3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RUNX3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RUNX3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RUNX3 gene:
    Search GeneIP for patents involving RUNX3

    Licensable Technologies for RUNX3 gene:
    Weizmann Institute:Treating T-cell related inflammatory conditions by targeting Runx3
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for RUNX3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of RUNX3
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for RUNX3 (RUNX3/CBFA3)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for RUNX3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RUNX3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RUNX3  
     OriGene Protein Over-expression Lysate for RUNX3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for RUNX3   OriGene 3'-UTR Clone for RUNX3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RUNX3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RUNX3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RUNX3   OriGene Custom Protein Services for RUNX3  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RUNX3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RUNX3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RUNX3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RUNX3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RUNX3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RUNX3
     GenScript Custom Purified and Recombinant Proteins Services for RUNX3 GenScript cDNA clones with any tag delivered in your preferred vector for RUNX3
     GenScript Custom Assay Services for RUNX3 GenScript Superior Antibodies for RUNX3
     GenScript Custom overexpressing Cell Line Services for RUNX3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for RUNX3  (AML2)

     Regulatory tfbs in RUNX3 promoter
     Search Chromatin IP Primers for RUNX3
     RT2 qPCR Primer Assay in human, mouse, rat RUNX3
     GNC Network for RUNX3
     SABiosciences PCR Arrays including human, mouse, rat RUNX3
     Search Tocris compounds for RUNX3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RUNX3 antibodies
     RUNX3 proteins
     RUNX3 lysates
     Search for Antibodies for RUNX3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for RUNX3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for RUNX3




     RUNX3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for RUNX3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUNX3
     SwitchGear 3'UTR luciferase reporter plasmids for RUNX3
     SwitchGear Promoter luciferase reporter plasmids for RUNX3
     ThermoFisher Antibody for RUNX3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUNX3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      RUNX3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4