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RUNX3 Gene

protein-coding GIFtS: 65

GC01M025098

runt-related transcription factor 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CBFA3)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AML2 ^¹, ², ³, ⁵
CBF-alpha-3 ^³
CBFA3 ^², ³, ⁵
FLJ34510 ^²
MGC16070 ^²
OTTHUMP00000003370 ^²
OTTHUMP00000003371 ^²
PEBP2A3 ^¹, ³, ⁵
PEBP2aC ^²

Descriptions
Acute myeloid leukemia 2 protein ^³
Core-binding factor subunit alpha-3 ^³
Oncogene AML-2 ^³
PEA2 alpha C ^²
PEA2-alpha C ^³
PEBP2 alpha C ^²
PEBP2-alpha C ^³
Polyomavirus enhancer-binding protein 2 alpha C subunit ^², ³
SL3-3 enhancer factor 1 alpha C subunit ^³
SL3/AKV core-binding factor alpha C subunit ^³
acute myeloid leukemia gene 2 ^²
core-binding factor, runt domain, alpha subunit 3 ^²
runt-related transcription factor 3 ^²
transcription factor AML2 ^²

External Ids
HGNC: 10473¹
Entrez Gene: 864²
UniProtKB: Q13761³
Ensembl: ENSG00000020633⁷

Search outside databases for aliases for RUNX3 gene

Previous GC identifers: GC01M024749 GC01M024294 GC01M024205 GC01M024577 GC01M024971

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for RUNX3:

This gene encodes a member of the runt domain-containing family of transcription factors. A

heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence

5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or

suppress transcription. It also interacts with other transcription factors. It functions as a

tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer.

Multiple transcript variants encoding different isoforms have been found for this gene. [provided

by RefSeq]

UniProtKB/Swiss-Prot: RUNX3_HUMAN, Q13761

Function: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters,

including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and

GM-CSF promoters

Gene Wiki entry for RUNX3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RUNX3 gene

Entrez Gene cytogenetic band: 1p36 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p36

RUNX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M025098: (about GC identifiers)

Start:	25,098,589 bp from pter
End:	25,164,088 bp from pter
Size:	65,500 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004610.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RUNX3_HUMAN, Q13761 (See protein sequence)

Recommended Name: Runt-related transcription factor 3

Size: 415 amino acids; 44356 Da

Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and

through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with TLE1 and

SUV39H1

Subcellular location: Nucleus

Secondary accessions: Q12969 Q13760

Alternative splicing: 2 isoforms: Q13761-1 Q13761-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001026850.1 NP_004341.1

ENSEMBL proteins:

ENSP00000382800 ENSP00000308051 ENSP00000343477

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (RUNX3)
	Human Recombinant Proteins from Abnova (RUNX3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	--
GO:0005737	cytoplasm	IDA	18029348
GO:0005794	Golgi apparatus	IDA	18029348

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Antibodies for RUNX3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for RUNX3 (RUNX3/CBFA3)
	Antibodies from Abcam (RUNX3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RUNX3)
	Novus Biologicals Antibodies for RUNX3

Assays for RUNX3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q13761

ProtoNet protein and cluster: Q13761

2 Blocks protein families:

IPB000040 Acute myeloid leukemia 1 protein signature

IPB013711 Runx inhibition

UniProtKB/Swiss-Prot: RUNX3_HUMAN, Q13761

Domain: A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional

activation of target genes

Similarity: Contains 1 Runt domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RUNX3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RUNX3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_004350

Applied Biosystems Silencer® siRNAs for RUNX3

Sigma-Aldrich siRNA for RUNX3

Sigma-Aldrich shRNA Panels and shRNA for RUNX3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for RUNX3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001031680
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001031680
untagged cDNA clones in CMV expression vector (see all 3): BC013362

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001031680

UniProtKB/Swiss-Prot: RUNX3_HUMAN, Q13761

Function: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters,

including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and

GM-CSF promoters

Genatlas biochemistry entry for RUNX3:

Drosophila Runt pair rule-related transcription factor 3,expressed in various lymphoid and myeloid

cells,involved in hematopoiesis and osteogenesis

14 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Runx3):

adipose tissue	behavior/neurological	digestive/alimentary	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal	muscle
nervous system	respiratory system	skeleton	skin/coat/nails

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	7607690
GO:0005515	protein binding	IPI	9751710
GO:0005524	ATP binding	NAS	7835892

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for RUNX3 (Your Favorite Gene powered by Ingenuity)

TGF-&beta

GeneDecks RUNX3 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for RUNX3

5/57 Interacting proteins for RUNX3 (Q13761¹ ENSP00000343477³) via UniProtKB, MINT, and/or STRING (see all 57 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TLE1	Q04724¹, ENSP00000347102³	EBI-925990, EBI-711424 STRING (score=.858)
CTNNB1	P35222¹, ENSP00000344456³	EBI-925990, EBI-491549 STRING (score=.792)
TCF7	P36402¹	EBI-925990, EBI-2119465
TCF7L2	Q9NQB0¹	EBI-925990, EBI-924724
Lef1 Lef1 (xeno)	P27782¹	EBI-925990, EBI-984464

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	NAS	7622058
GO:0006366	transcription from RNA polymerase II promoter	TAS	7607690
GO:0006917	induction of apoptosis	ISS	--
GO:0008283	cell proliferation	NAS	--
GO:0045786	negative regulation of cell cycle	ISS	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RUNX3
1 Novoseek chemical compound relationship for RUNX3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
oligonucleotide	0.00	1	16367903 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RUNX3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RUNX3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_004350

Sigma-Aldrich siRNA for RUNX3

Sigma-Aldrich shRNA Panels and shRNA for RUNX3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001031680 NM_004350

REFSEQ mRNAs for RUNX3 gene (2 alternative transcripts):

NM_001031680.2 NM_004350.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001031680 NM_004350

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001031680
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001031680
                                 untagged cDNA clones in CMV expression vector (see all 3): BC013362

Additional cDNA sequence:

AF022726.2 AJ001432.1 AK091829.1 AK300056.1 AK301044.1 AK310945.1 BC013362.2 CR591302.1

EF491807.1 EF491822.1 X79550.2 Z35278.1

10 DOTS entries:

DT.316245 DT.121417079 DT.95272569 DT.91761550 DT.121417078 DT.99935616 DT.121417056 DT.86852679

DT.91641553 DT.101962196

24/168 AceView cDNA sequences (see all 168 ):

C02403 BM917053 BQ054373 AA912790 AW276069 W94743 AI248006 CR591302

AA312733 BF478062 AI075058 BI908613 BM705361 AI131365 AL120686 BQ431324

AI492090 BQ054372 AA302999 AA809959 BG230606 AI092506 AF022726 BM915557

highest scoring ESTs for RUNX3:

BC013362 Z35278 AA250942 AA290877 AA302999 AA352709 AA355209 AA481586 AA911670 AF022726

Unigene Cluster for RUNX3:

Runt-related transcription factor 3

Hs.170019 [show with all ESTs]

Unigene Representative Sequence: NM_001031680

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000399916 ENST00000308873 ENST00000338888

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RUNX3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RUNX3

¹ / ² / ³

7 probe-sets matching RUNX3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
106_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	Z35278	0.80	1.00	0.91	1
234928_x_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
204197_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004350	0.60	1.00	0.82	1
204198_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA541630	0.40	1.00	0.76	1
234928_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204197_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204198_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks RUNX3 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGAGGTGTG

SOURCE GeneReport for Unigene cluster: Hs.170019
Expression variation in blood from EXPOLDB for RUNX3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RUNX3 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RUNX3¹	--	runt-related transcription factor 3	89.14(n) 92.13(a)	487366 XM_544492.2 XP_544492.2
chimpanzee (Pan troglodytes)	RUNX3¹	--	runt-related transcription factor 3	95.2(n) 96.4(a)	456633 XM_530106.2 XP_530106.2
cow (Bos taurus)	RUNX3¹	--	runt-related transcription factor 3	91.58(n) 94.36(a)	617389 XM_869638.2 XP_874731.2
rat (Rattus norvegicus)	Runx3¹	--	runt-related transcription factor 3	88.67(n) 92.8(a)	156726 NM_130425.1 NP_569109.1
mouse (Mus musculus)	Runx3^{1, 5}	4 (65.70 cM)⁵	runt related transcription factor 3^{1, 5}	89.18(n)¹ 93.13(a)¹	12399¹ NM_019732.2¹ NP_062706.2¹ AF085246⁵ AF155880⁵ (see all 16)

About this table Species with no ortholog for RUNX3

ENSEMBL Gene Tree for RUNX3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for RUNX3 gene

RUNX1² RUNX2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/294 NCBI SNPs in RUNX3 are shown (see all 294 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 152)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs13157^1,2	A,C,F,H,O	25100264(-)	`ATGTCC/TCTGTC`	2	--	ut3¹ ese³		6		EA MN EU WA	2086
	rs4265380^1,2	A,C,F,H	25165943(+)	`GGCTCT/CGTTAT`	1	--	ng3¹ tfbs³		11		EU EA WA NA	968
	rs7514332^1,2	A,C,F,H	25098262(+)	`CTCCCG/CAAATG`	2	--	ng5¹		8		EU EA WA	836
	rs6672420^1,2	A,C,F,H	25163597(+)	`CGCGGT/ATGAAG`	1	N/I	mis¹ ese³		11		EU EA WA NA	976
--	rs16830118^1,2	F,H	25099339(+)	`GGAGGG/TAATGG`	2	--	ut3¹		7		NA EU EA WA	560
	rs7528699^1,2	F,H	25165442(+)	`TGGGGC/TTAGAA`	1	--	ng3¹		4		EU EA WA	414
--	rs7528484^1,2	A,C	25165255(+)	`GGTGAC/TGCCAG`	1	--	ng3¹		0	--	--	--	--
	rs4649037^1,2	A,C	25130888(+)	`TCACAG/TCACGC`	2	--	int¹ ng3¹		0	--	--	--	--
--	rs11249203^1,2	A,C	25131172(+)	`CCGCTC/GTTTCA`	2	--	ng3¹ int¹		0	--	--	--	--
--	rs7414934^1,2	A	25165803(+)	`TGGGGA/CAAGTC`	1	--	ng3¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for RUNX3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600210

10/28 Novoseek disease relationships for RUNX3 gene (see all 28 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
microsatellite instability	78.85	4	15386381 (1), 19117505 (1), 15273736 (1)
gastric cancer	74.72	137	17085650 (7), 15386419 (6), 19290488 (6), 16140942 (6) (see all 42)
colorectal cancer	63.00	45	16080503 (5), 19223906 (3), 17270239 (3), 15273736 (3) (see all 17)
gastric carcinoma	58.05	26	15051926 (6), 17956589 (3), 14968123 (3), 15379759 (2) (see all 9)
tumors	56.97	139	19336521 (5), 15386381 (4), 18410404 (4), 18288406 (4) (see all 66)
cleidocranial dysplasia	49.57	1	15138260 (1)
cancer	48.79	54	17914577 (3), 18639281 (3), 18430739 (3), 14968123 (3) (see all 29)
leukemogenesis	46.94	2	12370805 (1), 12682904 (1)
colon cancer	40.97	23	15386381 (7), 18949360 (6), 18772112 (1), 14968123 (1) (see all 5)
gastric tumor	40.15	3	18772112 (1), 16738314 (1), 15930301 (1)

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Human Genome Epidemiology Navigator: RUNX3 (6 documents)

(Possibly Related Articles in Doctor's Guide)
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ASCO-GI: Bortezomib Fails to Show Single-Agent Activity in Patients With Advanced Gastric Cancer

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/207 PubMed articles for RUNX3 gene (see all 207 ):

AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization. (PubMed id 7835892)^{2, 3, 4} Levanon D....Groner Y. (1994)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription. (PubMed id 16652147)^{3, 4} Reed-Inderbitzin E.... Hiebert S.W. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. (PubMed id 9751710)^{3, 4} Levanon D.... Groner Y. (1998)
Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog, CBFA3, to chromosome 1p35- pter. (PubMed id 7607690)^{3, 4} Wijmenga C....Collins F.S. (1995)
Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain. (PubMed id 7622058)^{3, 4} Bae S.-C.... Ito Y. (1995)
Expression of RUNX3 gene, methylation status and clinicopathological significance in breast cancer and breast cancer cell lines. (PubMed id 18580070)^{1, 3} Jiang Y....Geng J. (2008)
RUNX3 protein is overexpressed in human epithelial ovarian cancer. (PubMed id 18937968)^{1, 3} Nevadunsky N.S....Mok S.C. (2009)
Frequent silencing of RUNX3 in esophageal squamous cell carcinomas is associated with radioresistance and poor prognosis. (PubMed id 17384682)^{1, 3} Sakakura C....Ito Y. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 864	HGNC: 10473	AceView: RUNX3	Ensembl:ENSG00000020633	euGenes: HUgn864
ECgene: RUNX3	H-InvDB: RUNX3

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for RUNX3	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for RUNX3
(Available from WIS Yeda, Salk, Tufts)

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Licensable Technologies for RUNX3 gene:

Weizmann Institute:

Treating T-cell related inflammatory conditions by targeting Runx3

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for RUNX3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RUNX3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RUNX3		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RUNX3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (RUNX3)
	Antibodies (RUNX3)
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Antibodies for RUNX3

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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RUNX3 Gene at Home site.
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RUNX3 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for RUNX3

Summaries
for RUNX3

Genomic Location
for RUNX3

Proteins
for RUNX3

Protein Domains/
Families
for RUNX3

Gene Function
for RUNX3

Pathways & Interactions
for RUNX3

Drugs & Compounds
for RUNX3

Transcripts
for RUNX3

Expression
for RUNX3

Orthologs
for RUNX3

Paralogs
for RUNX3

SNPs/Variants
for RUNX3

Disorders & Mutations
for RUNX3

Medical News
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Publications
for RUNX3

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RUNX3 (Gene Symbol)
AML2
CBF-alpha-3
CBFA3
FLJ34510
MGC16070
OTTHUMP00000003370
OTTHUMP00000003371
PEBP2A3
PEBP2aC
Acute myeloid leukemia 2 protein
Core-binding factor subunit alpha-3
Oncogene AML-2
PEA2 alpha C
PEA2-alpha C
PEBP2 alpha C
PEBP2-alpha C
Polyomavirus enhancer-binding protein 2 alpha C subunit
SL3-3 enhancer factor 1 alpha C subunit
SL3/AKV core-binding factor alpha C subunit
acute myeloid leukemia gene 2
core-binding factor, runt domain, alpha subunit 3
runt-related transcription factor 3
transcription factor AML2

RUNX3 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor RUNX3

Summariesfor RUNX3

Genomic Locationfor RUNX3

Proteinsfor RUNX3

Protein Domains/Familiesfor RUNX3

Gene Functionfor RUNX3

Pathways & Interactionsfor RUNX3

Drugs & Compoundsfor RUNX3

Transcriptsfor RUNX3

Expression for RUNX3

Orthologsfor RUNX3

Paralogsfor RUNX3

SNPs/Variantsfor RUNX3

Disorders & Mutationsfor RUNX3

Medical Newsfor RUNX3

Publicationsfor RUNX3

Search for RUNX3

Genome Databases showing RUNX3

Other Databases showing RUNX3

Specialized Databases showing RUNX3

Licensable Technologiesfor RUNX3

Servicesfor RUNX3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RUNX3

Summaries
for RUNX3

Genomic Location
for RUNX3

Proteins
for RUNX3

Protein Domains/
Families
for RUNX3

Gene Function
for RUNX3

Pathways & Interactions
for RUNX3

Drugs & Compounds
for RUNX3

Transcripts
for RUNX3

Expression
for RUNX3

Orthologs
for RUNX3

Paralogs
for RUNX3

SNPs/Variants
for RUNX3

Disorders & Mutations
for RUNX3

Medical News
for RUNX3

Publications
for RUNX3

Licensable Technologies
for RUNX3

Services
for RUNX3