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RUNX3 Gene

protein-coding   GIFtS: 68
GCID: GC01M025226

Runt-Related Transcription Factor 3


(Previous symbol: CBFA3)
  See RUNX3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Runt-Related Transcription Factor 31 2     SL3-3 Enhancer Factor 1 Alpha C Subunit2 3
CBFA31 2 3 5     SL3/AKV Core-Binding Factor Alpha C Subunit2 3
AML22 3 5     PEBP2A33 5
Acute Myeloid Leukemia 2 Protein2 3     PEBP2aC2
Core-Binding Factor Subunit Alpha-32 3     Acute Myeloid Leukemia Gene 22
Oncogene AML-22 3     Core-Binding Factor, Runt Domain, Alpha Subunit 32
Polyomavirus Enhancer-Binding Protein 2 Alpha C Subunit2 3     PEA2 Alpha C2
CBF-alpha-32 3     PEBP2 Alpha C2
PEA2-Alpha C2 3     Transcription Factor AML22
PEBP2-Alpha C2 3     

External Ids:    HGNC: 104731   Entrez Gene: 8642   Ensembl: ENSG000000206337   OMIM: 6002105   UniProtKB: Q137613   
ORGUL members:         

Export aliases for RUNX3 gene to outside databases

Previous GC identifers: GC01M024749 GC01M024294 GC01M024205 GC01M024577 GC01M024971 GC01M025098 GC01M023479


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RUNX3 Gene:
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this
protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number
of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other
transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or
transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for RUNX3 Gene:
RUNX3 (runt-related transcription factor 3) is a protein-coding gene. Diseases associated with RUNX3 include esophagus squamous cell carcinoma, and testicular yolk sac tumor. GO annotations related to this gene include RNA polymerase II regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is RUNX1.

UniProtKB/Swiss-Prot: RUNX3_HUMAN, Q13761
Function: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine
leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters

Gene Wiki entry for RUNX3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RUNX3 gene promoter:
         STAT1   STAT2   p300   STAT1beta   STAT3   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRUNX3 promoter sequence
   Search Chromatin IP Primers for RUNX3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RUNX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36

RUNX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RUNX3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M025226:  view genomic region     (about GC identifiers)

Start:
25,226,002 bp from pter      End:
25,291,612 bp from pter
Size:
65,611 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for RUNX3

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RUNX3_HUMAN, Q13761 (See protein sequence)
Recommended Name: Runt-related transcription factor 3  
Size: 415 amino acids; 44356 Da
Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt
domain. DNA-binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1. The tyrosine
phosphorylated form (via runt domain) interacts with SRC (via protein kinase domain). Interacts with FYN and LCK
Secondary accessions: B1AJV5 Q12969 Q13760
Alternative splicing: 2 isoforms:  Q13761-1   Q13761-2   

Explore the universe of human proteins at neXtProt for RUNX3: NX_Q13761

Explore proteomics data for RUNX3 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues by SRC. Phosphorylated by LCK and FYN1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RUNX3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001026850.1  NP_004341.1  

    ENSEMBL proteins: 
     ENSP00000308051   ENSP00000343477   ENSP00000382800   ENSP00000444872  

    RUNX3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RUNX3
    OriGene Protein Over-expression Lysate for RUNX3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RUNX3
    GenScript Custom Purified and Recombinant Proteins Services for RUNX3
    Novus Biologicals RUNX3 Proteins
    Novus Biologicals RUNX3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for RUNX3
    Cloud-Clone Corp. Proteins for RUNX3

     
    Search eBioscience for Proteins for RUNX3 

    RUNX3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RUNX3
    R&D Systems Antibodies for RUNX3 (RUNX3/CBFA3)
    Cell Signaling Technology (CST) Antibodies for RUNX3  (AML2)
    OriGene Antibodies for RUNX3
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    Novus Biologicals RUNX3 Antibodies
    Abcam antibodies for RUNX3
    Cloud-Clone Corp. Antibodies for RUNX3
    ThermoFisher Antibody for RUNX3
    LSBio Antibodies in human, mouse, rat for RUNX3

    RUNX3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RUNX3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RUNX3
    Cloud-Clone Corp. CLIAs for RUNX3
    Search eBioscience for ELISAs for RUNX3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR012346 p53/RUNT-type_TF_DNA-bd
     IPR000040 AML1_Runt
     IPR008967 p53-like_TF_DNA-bd
     IPR016554 TF_Runt-rel_RUNX
     IPR013711 RunxI_C_dom

    Graphical View of Domain Structure for InterPro Entry Q13761

    ProtoNet protein and cluster: Q13761

    2 Blocks protein domains:
    IPB000040 Acute myeloid leukemia 1 protein signature
    IPB013711 Runx inhibition


    UniProtKB/Swiss-Prot: RUNX3_HUMAN, Q13761
    Domain: A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of
    target genes
    Similarity: Contains 1 Runt domain


    Find genes that share domains with RUNX3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RUNX3_HUMAN, Q13761
    Function: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine
    leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters

         Genatlas biochemistry entry for RUNX3:
    Drosophila Runt pair rule-related transcription factor 3,expressed in various lymphoid and myeloid cells,involved
    in hematopoiesis and osteogenesis

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding ISS--
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity ISS--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity TAS7607690
    GO:0005515protein binding IPI18772112
         
    Find genes that share ontologies with RUNX3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RUNX3:
     Increased gamma-H2AX phosphory 

         Selected MGI mutant phenotypes (inferred from 7 alleles(MGI details for Runx3) (see all 16):
     adipose tissue  behavior/neurological  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  integument 
     mortality/aging  muscle  nervous system  no phenotypic analysis  respiratory system 

    Find genes that share phenotypes with RUNX3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Runx3tm2Yg for RUNX3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RUNX3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RUNX3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RUNX3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RUNX3

    miRNA
    Products:
        
    miRTarBase miRNAs that target RUNX3:
    hsa-mir-93-5p (MIRT028012), hsa-mir-130b-3p (MIRT003316), hsa-mir-148b-3p (MIRT019365), hsa-mir-130a-3p (MIRT007055), hsa-mir-301a-3p (MIRT007295), hsa-mir-532-5p (MIRT000038)

    Block miRNA regulation of human, mouse, rat RUNX3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RUNX3 (see all 67):
    hsa-miR-520e hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-637 hsa-miR-130b hsa-miR-520b hsa-miR-20a
    SwitchGear 3'UTR luciferase reporter plasmidRUNX3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RUNX3
    Predesigned siRNA for gene silencing in human, mouse, rat RUNX3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RUNX3

    Clone
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    OriGene clones in human, mouse for RUNX3 (see all 13)
    OriGene ORF clones in mouse, rat for RUNX3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RUNX3 (NM_004350)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RUNX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUNX3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for RUNX3
    Browse ESI BIO Cell Lines and PureStem Progenitors for RUNX3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUNX3

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-14279 VA4-13985) for RUNX3 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RUNX3_HUMAN, Q13761: Nucleus. Cytoplasm. Note=The tyrosine phosphorylated form localizes to the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin ISS--
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with RUNX3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RUNX3 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1TGF Beta Signaling Pathway
    TGF Beta Signaling Pathway
    2TGF-beta/Smad Signaling
    TGF-beta/Smad Signaling
    3TGF-beta Signaling Pathways
    TGF-beta Signaling Pathways
    4SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways
    5Notch Signaling Pathways
    Notch Signaling Pathways


    Find genes that share SuperPaths with RUNX3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for RUNX3
        Notch Signaling Pathways
    TGF-beta Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for RUNX3
        TGF-beta/Smad Signaling

    3 BioSystems Pathways for RUNX3
        TGF Beta Signaling Pathway
    SIDS Susceptibility Pathways
    Endochondral Ossification


        Pathway & Disease-focused RT2 Profiler PCR Arrays including RUNX3: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Leukemia in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              Liver Cancer in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RUNX3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RUNX3 (Q137611, 2, 3 ENSP000003434774) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC4P565241, 3, ENSP000002646064EBI-925990,EBI-308629 I2D: score=2 STRING: ENSP00000264606
    TCF7L2Q9NQB01, 3, ENSP000003584044EBI-925990,EBI-924724 I2D: score=1 STRING: ENSP00000358404
    CTNNB1P352221, 3, ENSP000003444564EBI-925990,EBI-491549 I2D: score=1 STRING: ENSP00000344456
    EP300Q094721, 3, ENSP000002632534EBI-925990,EBI-447295 I2D: score=3 STRING: ENSP00000263253
    HDAC5Q9UQL61, 3, ENSP000002259834EBI-925990,EBI-715576 I2D: score=2 STRING: ENSP00000225983
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0002062chondrocyte differentiation IEA--
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated NAS7622058
    GO:0006366transcription from RNA polymerase II promoter TAS7607690

    Find genes that share ontologies with RUNX3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RUNX3

    5 Novoseek inferred chemical compound relationships for RUNX3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 76.1 14 15386381 (1), 16328045 (1), 18848767 (1), 17384682 (1) (see all 11)
    oligonucleotide 0 1 16367903 (1)
    serine 0 1 10419474 (1)
    retinoic acid 0 10 10419474 (5), 17270239 (1)
    vegf 0 5 17085650 (5)



    Find genes that share compounds with RUNX3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RUNX3 gene (2 alternative transcripts): 
    NM_001031680.2  NM_004350.2  

    Unigene Cluster for RUNX3:

    Runt-related transcription factor 3
    Hs.170019  [show with all ESTs]
    Unigene Representative Sequence: NM_001031680
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308873(uc001bjq.3 uc010oen.2) ENST00000338888(uc009vrl.1)
    ENST00000496967 ENST00000479341 ENST00000399916(uc009vrj.3 uc001bjr.3 uc009vrk.3)
    ENST00000540420
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RUNX3 (see all 67):
    hsa-miR-520e hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-637 hsa-miR-130b hsa-miR-520b hsa-miR-20a
    SwitchGear 3'UTR luciferase reporter plasmidRUNX3 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): RUNX3 (NM_004350)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUNX3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RUNX3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RUNX3
      QuantiTect SYBR Green Assays in human, mouse, rat RUNX3
      QuantiFast Probe-based Assays in human, mouse, rat RUNX3
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-14279 VA4-13985) for RUNX3 

    Additional mRNA sequence: 

    AF022726.2 AJ001432.1 AK091829.1 AK300056.1 AK301044.1 AK310945.1 BC013362.2 EF491807.1 
    EF491822.1 X79550.2 Z35278.1 

    10 DOTS entries:

    DT.316245  DT.121417079  DT.95272569  DT.91761550  DT.121417078  DT.99935616  DT.91641553  DT.101962196 
    DT.121417056  DT.86852679 

    Selected AceView cDNA sequences (see all 168):

    AI248006 AW951046 BM917053 W94743 BM915557 AF022726 BF478062 AI524028 
    BQ431324 AI636867 C02403 BG230606 BQ708535 AA912790 AI685772 AA312733 
    AI633590 BE677415 AL120686 AI492090 CR591302 AI092506 AI079556 CA432310 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    RUNX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAGGTGTG
    RUNX3 Expression
    About this image


    RUNX3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 24 entries
             Prehypertrophic Chondrocytes Vertebrae
             Rib
             HyStem+BMP4-induced E15 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 19 entries
             Hypertrophic Chondrocytes Temporomandibular Joint
             HyStem+BMP4-induced E15 cells
     
     Melanocytes (Integumentary System)    fully expand to see all 4 entries
             Human EpiDermal Melanocytes-dark (HEM-dark)   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; non-germinal center cells   
     
     Epidermis (Integumentary System)    fully expand to see all 3 entries
             Human EpiDermal Melanocytes-dark (HEM-dark)   
    RUNX3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RUNX3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.170019
        Pathway & Disease-focused RT2 Profiler PCR Arrays including RUNX3: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Leukemia in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              Liver Cancer in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for RUNX3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RUNX3
    QuantiTect SYBR Green Assays in human, mouse, rat RUNX3
    QuantiFast Probe-based Assays in human, mouse, rat RUNX3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUNX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for RUNX3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Runx31 , 5 runt related transcription factor 31, 5 89.18(n)1
    93.13(a)1
      4 (67.19 cM)5
    123991  NM_019732.21  NP_062706.21 
     1351206525 
    chicken
    (Gallus gallus)
    Aves RUNX31 runt-related transcription factor 3 80.56(n)
    87.47(a)
      769687  XM_001232977.3  XP_001232978.3 
    lizard
    (Anolis carolinensis)
    Reptilia RUNX36
    runt-related transcription factor 3
    64(a)
    1 ↔ 1
    GL343464.1(6005-52673)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia runx31 runt-related transcription factor 3 72.55(n)
    81.07(a)
      100485729  XM_002936597.2  XP_002936643.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AB043788.12   -- 76.94(n)   58127  AB043788.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG13793 transcription factor 73(a)
    (best of 4)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea rnt-16
    Protein RNT-1 (rnt-1) mRNA, complete cds
    28(a)
    1 → many
    I(5776154-5788609) WBGene00004393


    ENSEMBL Gene Tree for RUNX3 (if available)
    TreeFam Gene Tree for RUNX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RUNX3 gene
    RUNX12  RUNX22  
    6 SIMAP similar genes for RUNX3 using alignment to 2 protein entries:     RUNX3_HUMAN (see all proteins):
    AML2    RUNX1/C20orf112 fusion    RUNX1    RUNX2    RUNX1/CBFA2T2 fusion    C20orf112/RUNX1 fusion

    Find genes that share paralogs with RUNX3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RUNX3 (see all 1240)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs75143321,2
    C,F,A,H--25225675(+) CTCCCG/CAAATG 2 -- ds500115Minor allele frequency- C:0.22NS EA WA NA CSA 1202
    rs1158542881,2
    C,F--25225680(+) GAAATG/CTGAAT 2 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1909602441,2
    --25225777(+) GAAGAC/TCTATT 2 -- ds50010--------
    rs1821096711,2
    --25225856(+) TCTGCA/GGCCAT 2 -- ds50010--------
    rs1876009261,2
    C--25225929(+) GGCAAA/CAGCAG 2 -- ds50010--------
    rs1449151861,2
    C--25225933(+) ACAGC-/AGGAGGTC 2 -- ds50010--------
    rs1459018541,2
    C--25225953(+) TCTCCC/TCCACC 2 -- ds50010--------
    rs1928335311,2
    --25225990(+) GAAACC/TGGGCA 2 -- ds50010--------
    rs1383565451,2
    --25226078(+) CAGAAA/GACAGT 2 -- ut310--------
    rs1488368861,2
    --25226106(+) TGTGCA/GTTAAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for RUNX3 (25226002 - 25291612 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RUNX3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv871803CNV Loss21882294
    nsv508581CNV Loss20534489
    nsv870740CNV Gain21882294

    Human Gene Mutation Database (HGMD): RUNX3
    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing RUNX3:
    Oncogenes & Tumor Suppressor Genes 384HC
    Pancreatic Cancer
    SeqTarget long-range PCR primers for resequencing RUNX3
    DNA2.0 Custom Variant and Variant Library Synthesis for RUNX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600210    OMIM disorders: --

    7 diseases for RUNX3:    
    About MalaCards
    esophagus squamous cell carcinoma    testicular yolk sac tumor    myeloid leukemia    cleidocranial dysplasia
    adenoid cystic carcinoma    acute myeloid leukemia    leukemia

    3 diseases from the University of Copenhagen DISEASES database for RUNX3:
    Cleidocranial dysplasia     Colorectal cancer     Carcinoma

    Find genes that share disorders with RUNX3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for RUNX3 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    microsatellite instability 81.1 6 15386381 (1), 19470733 (1), 19789368 (1), 19117505 (1) (see all 5)
    gastric cancer 75.4 163 17085650 (7), 15386419 (6), 16140942 (6), 19290488 (6) (see all 49)
    colorectal cancer 66.8 51 16080503 (5), 19223906 (3), 15273736 (3), 17270239 (3) (see all 20)
    tumors 59.8 174 19336521 (6), 20348954 (5), 15386381 (4), 18410404 (4) (see all 83)
    gastric tumor 58.5 7 18772112 (1), 20490322 (1), 20353948 (1), 20492341 (1) (see all 7)
    gastric carcinoma 56.9 31 15051926 (6), 20485621 (4), 17956589 (3), 14968123 (3) (see all 10)
    colon cancer 54.8 24 15386381 (7), 18949360 (6), 18772112 (1), 14968123 (1) (see all 6)
    cancer 54.7 71 17914577 (3), 18639281 (3), 14968123 (3), 18430739 (3) (see all 39)
    leukemogenesis 48.6 2 12370805 (1), 12682904 (1)
    cleidocranial dysplasia 46.4 1 15138260 (1)

    Genetic Association Database (GAD): RUNX3
    Human Genome Epidemiology (HuGE) Navigator: RUNX3 (17 documents)

    Export disorders for RUNX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RUNX3 gene, integrated from 10 sources (see all 356):
    (articles sorted by number of sources associating them with RUNX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. AML1, AML2, and AML3, the human members of the runt domain gene- family: cDNA structure, expression, and chromosomal localization. (PubMed id 7835892)1, 2, 3 Levanon D.... Groner Y. (Genomics 1994)
    2. Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm. (PubMed id 20100835)1, 2, 9 Goh Y.M.... Bae S.C. (J. Biol. Chem. 2010)
    3. Genetic variants in the Runt-related transcription factor 3 gene contribute to gastric cancer risk in a Chinese population. (PubMed id 19552756)1, 4, 9 Wu D....Zhang Z. (Cancer Sci. 2009)
    4. Chromatin immunoprecipitation and association study revealed a possible role of Runt-related transcription factor 3 in the ulcerative colitis of Chinese population. (PubMed id 20392673)1, 4, 9 Guo C....Ding J. (Clin. Immunol. 2010)
    5. Genetic variants in RUNX3 and risk of bladder cancer: a haplotype-based analysis. (PubMed id 18684727)1, 4, 9 Zhang Z....Zhang Z. (Carcinogenesis 2008)
    6. [The relationship between RUNX3 gene mutation and keloid]. (PubMed id 18717361)1, 4, 9 Zhang G....Yu Q. (Zhonghua Zheng Xing Wai Ke Za Zhi 2008)
    7. Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. (PubMed id 21743469)1, 4 Evans D.M.... . (Nat. Genet. 2011)
    8. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    9. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    10. Significant association of RUNX3 T/A polymorphism at intron 3 (rs760805) with the risk of gastric atrophy in Helicobacter pylori seropositive Japanese. (PubMed id 19728008)1, 4 Hishida A....Hamajima N. (J. Gastroenterol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 864 HGNC: 10473 AceView: RUNX3 Ensembl:ENSG00000020633 euGenes: HUgn864
    ECgene: RUNX3 H-InvDB: RUNX3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RUNX3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RUNX3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RUNX3 gene:
    Search GeneIP for patents involving RUNX3

    Licensable Technologies for RUNX3 gene:
    Weizmann Institute:Treating T-cell related inflammatory conditions by targeting Runx3
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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