Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RUNX2 Gene

protein-coding GIFtS: 68
GCID: GC06P045295

runt-related transcription factor 2

(Previous symbols: CCD, CBFA1, CCD1)

Explore 66 diseases affiliated with
RUNX2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Runt-Related Transcription Factor 2¹ ²		OSF-2² ³
AML3¹ ² ³ ⁵		OSF2² ³
CBFA1¹ ² ³ ⁵		PEA2-Alpha A² ³
PEBP2A1¹ ² ⁵		PEBP2-Alpha A² ³
CCD¹ ²		SL3-3 Enhancer Factor 1 Alpha A Subunit² ³
CCD1¹ ²		SL3/AKV Core-Binding Factor Alpha A Subunit² ³
PEBP2aA1¹ ²		PEA2aA²
Acute Myeloid Leukemia 3 Protein² ³		PEBP2A2²
Oncogene AML-3² ³		PEBP2aA²
Osteoblast-Specific Transcription Factor 2² ³		Core-Binding Factor, Runt Domain, Alpha Subunit 1²
Polyomavirus Enhancer-Binding Protein 2 Alpha A Subunit² ³		PEBP2A³
CBF-Alpha-1¹		Core-Binding Factor Subunit Alpha-1³

External Ids:	HGNC: 10472¹	Entrez Gene: 860²	Ensembl: ENSG00000124813⁷	OMIM: 600211⁵	UniProtKB: Q13950³

Export aliases for RUNX2 gene to outside databases

Previous GC identifers: GC06P045392 GC06P045437 GC06P045498 GC06P045018

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RUNX2:

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt

DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as

a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA

both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been

associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different

protein isoforms result from the use of alternate promoters as well as alternate splicing. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: RUNX2_HUMAN, Q13950

Function: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the

maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site,

5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell

receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters.

In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of

the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation

Gene Wiki entry for RUNX2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RUNX2 gene promoter:
PPAR-gamma1 AP-1 MyoD PPAR-gamma2 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RUNX2 promoter sequence

Search SABiosciences Chromatin IP Primers for RUNX2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RUNX2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p21

RUNX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RUNX2 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P045295: view genomic region (about GC identifiers)

Start:	45,295,894 bp from pter	End:	45,632,086 bp from pter
Size:	336,193 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RUNX2_HUMAN, Q13950 (See protein sequence)

Recommended Name: Runt-related transcription factor 2

Size: 521 amino acids; 56648 Da

Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt

domain. DNA-binding is increased by heterodimerization. Interacts with XRCC6 (Ku70) and XRCC5 (Ku80). Interacts with

HIVEP3. Interacts with IFI204. Interaction with SATB2; the interaction results in enhanced DNA binding and

transactivation by these transcription factors. Binds to HIPK3. Interacts (isoform 3) with DDX5. Interacts with FOXO1

(via a C-terminal region); the interaction inhibits RUNX2 transcriptional activity towards BGLAP. This interaction is

prevented on insulin or IGF1 stimulation as FOXO1 is exported from the nucleus (By similarity). Interacts with CCNB1,

KAT6A and KAT6B

Subcellular location: Nucleus

Secondary accessions: O14614 O14615 O95181

Alternative splicing: 3 isoforms: Q13950-1 Q13950-2 Q13950-3 (Contains a phosphoserine at position 340)

Explore the universe of human proteins at neXtProt for RUNX2: NX_Q13950

Post-translational modifications:

Phosphorylated; probably by MAP kinases (MAPK). Phosphorylation by HIPK3 is required for the SPEN/MINT and FGF2

transactivation during osteoblastic differentiation (By similarity). Phosphorylation at Ser-451 by CDK1 promotes

endothelial cell proliferation required for tumor angiogenesis probably by facilitating cell cycle progression.

Isoform 3 is phosphorylated on Ser-340¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13950

RUNX2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001015051.3 NP_001019801.3 NP_004339.3

ENSEMBL proteins:

ENSP00000461357 ENSP00000420707 ENSP00000360493 ENSP00000360491 ENSP00000458178

ENSP00000460188 ENSP00000352514 ENSP00000319087 ENSP00000446290 ENSP00000360486

Reactome Protein details: Q13950
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): RUNX2 OriGene Custom Protein Services for RUNX2
	GenScript Custom Purified and Recombinant Proteins Services for RUNX2
	Novus Biologicals RUNX2 Proteins Novus Biologicals RUNX2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RUNX2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000790	nuclear chromatin	ISS	--
GO:0005634	nucleus	IDA	--
GO:0005667	transcription factor complex	IEA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IEA	--

RUNX2 for ontologies About GeneDecksing

RUNX2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of RUNX2
	R&D Systems Antibodies for RUNX2 (RUNX2/CBFA1)
	Cell Signaling Technology (CST) Antibodies for RUNX2 (AML3)
	OriGene Antibodies (see all 2): RUNX2 OriGene Custom Antibody Services for RUNX2
	GenScript Custom Superior Antibodies Services for RUNX2
	Novus Biologicals RUNX2 Antibodies
	Abcam antibodies for RUNX2
	Uscn Antibodies for RUNX2
	ThermoFisher Antibodies for RUNX2

Assay Products for RUNX2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Transcription Factor Binding & Immunoprecipitation Assays for RUNX2 (RUNX2/CBFA1)
	GenScript Custom Assay Services for RUNX2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RUNX2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RUNX2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR012346 p53/RUNT-type_TF_DNA-bd

IPR000040 AML1_Runt

IPR008967 p53-like_TF_DNA-bd

IPR016554 TF_Runt-rel_RUNX

IPR013711 RunxI

Graphical View of Domain Structure for InterPro Entry Q13950

ProtoNet protein and cluster: Q13950

2 Blocks protein families:

IPB000040 Acute myeloid leukemia 1 protein signature

IPB013711 Runx inhibition

UniProtKB/Swiss-Prot: RUNX2_HUMAN, Q13950

Domain: A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target

genes and contains the phosphorylation sites

Similarity: Contains 1 Runt domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RUNX2_HUMAN, Q13950

Function: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the

maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site,

5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell

receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters.

In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of

the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation

Genatlas biochemistry entry for RUNX2:

Drosophila Runt pair rule-related transcription factor,expressed in T lymphocyte-derived cell lines,osteoblast-specific

transcription factor,regulating osteoblast differentiation,binding to the osteocalcin promoter,regulated by BMP7 and

vitamin D3,and essential for membranous and encochondreal bone formation,also involved in hematopoietic stem cells

differentiation,

miRNA Products:		miRTarBase miRNAs that target RUNX2: hsa-mir-335 (MIRT005888), hsa-mir-135b (MIRT003597), hsa-mir-155 (MIRT004707)

		OriGene 3'-UTR Clone (see all 3): RUNX2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RUNX2
		8/63 QIAGEN miScript miRNA Assays for microRNAs that regulate RUNX2 (see all 63):
		hsa-miR-607 hsa-miR-302d hsa-miR-520e hsa-miR-485-3p hsa-miR-30d hsa-miR-519a hsa-miR-218 hsa-miR-4275

		SwitchGear 3'UTR luciferase reporter plasmid: RUNX2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RUNX2 (see all 4) OriGene shRNA RFP: RUNX2 OriGene siRNA: RUNX2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RUNX2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RUNX2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RUNX2 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RUNX2 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): RUNX2 (NM_001024630)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RUNX2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUNX2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RUNX2
		LifeMap BioReagents: cell lines associated with RUNX2: PureStem SK11, NCr-fac & Meso-prx Progenitor, PureStem SM30, NCr-fac & Meso-latp Progenitor

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUNX2

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003682	chromatin binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0005515	protein binding	IPI	16299379
GO:0005524	ATP binding	IEA	--

RUNX2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for RUNX2:

Downregulation of NF-kappaB pa

Animal Models:
Mouse knock-outs for RUNX2: Runx2^tm1Ldq Runx2^tm1.1Jals Runx2^tm1Kish
15/20 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Runx2) (see all 20):

cardiovascular system	cellular	craniofacial	digestive/alimentary	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	immune system	integument
limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system

RUNX2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Transcription_Role of VDR in regulation of genes involved in osteoporosis

Transcription_Role of VDR in regulation of genes involved in osteoporosis

1.00

Transcription Role of VDR in regulation of genes involved in osteoporosis

0.80

Development_Hedgehog and PTH signaling pathways in bone and cartilage development

Development_Hedgehog and PTH signaling pathways in bone and cartilage development

1.00

Development Hedgehog and PTH signaling pathways in bone and cartilage development

0.97

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

YAP1- and WWTR1 (TAZ)-stimulated gene expression

YAP1- and WWTR1 (TAZ)-stimulated gene expression

1.00

Interleukin-11 Signaling Pathway

Interleukin-11 Signaling Pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for RUNX2

	Development Hedgehog and PTH signaling pathways in bone and cartilage development
	Transcription Role of VDR in regulation of genes involved in osteoporosis

1 R&D Systems Pathway for RUNX2

TGF-beta Signaling Pathways

2 GeneGo (Thomson Reuters) Pathways for RUNX2

	Development Hedgehog and PTH signaling pathways in bone and cartilage development
	Transcription Role of VDR in regulation of genes involved in osteoporosis

5/11 BioSystems Pathways for RUNX2 (see all 11)

	BMP signalling and regulation
	TGF Beta Signaling Pathway
	Endochondral Ossification
	TGF-beta Receptor Signaling Pathway
	Androgen receptor signaling pathway

3 Reactome Pathways for RUNX2

	Generic Transcription Pathway
	Gene Expression
	YAP1- and WWTR1 (TAZ)-stimulated gene expression

RUNX2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RUNX2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/68 Interacting proteins for RUNX2 (Q13950^{1, 3} ENSP00000352514⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 68)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMAD6	O43541¹^,³, ENSP00000288840⁴	EBI-976402,EBI-976374 I2D: score=2 STRING: ENSP00000288840
HDAC4	P56524³, ENSP00000264606⁴	I2D: score=5 STRING: ENSP00000264606
HDAC3	O15379³, ENSP00000302967⁴	I2D: score=3 STRING: ENSP00000302967
HDAC6	Q9UBN7³, ENSP00000334061⁴	I2D: score=3 STRING: ENSP00000334061
JUN	P05412³, ENSP00000360266⁴	I2D: score=3 STRING: ENSP00000360266

About this table

Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	--	--
GO:0001503	ossification	TAS	12217689
GO:0001649	osteoblast differentiation	TAS	12217689
GO:0001958	endochondral ossification	IEA	--
GO:0002051	osteoblast fate commitment	IEA	--

RUNX2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RUNX2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RUNX2
10/46 Novoseek chemical compound relationships for RUNX2 gene (see all 46) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alizarin	80.6	2	15853967 (1), 18847334 (1)
dexamethasone	58.3	64	17950631 (8), 15368363 (4), 11135373 (3), 17707772 (3) (see all 19)
hydroxyapatite	54.3	3	17516856 (1), 20398935 (1), 20077014 (1)
polycaprolactone	48.6	1	20398935 (1)
tgf beta1	44.9	5	15107836 (3), 18554936 (1)
titanium	43.8	8	16634490 (2), 17049981 (1), 18688796 (1), 19733525 (1) (see all 5)
ascorbic acid	42.4	29	17274723 (3), 14648194 (2), 11771655 (1), 17956465 (1) (see all 7)
strontium ranelate	39.2	4	17300752 (2), 17579299 (1), 19563530 (1)
calcium	34.5	13	16637042 (1), 18160010 (1), 18366626 (1), 17702986 (1) (see all 13)
pd 98,059	33.4	8	19807253 (2), 10660618 (1), 19438323 (1), 20517899 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about RUNX2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RUNX2 gene (3 alternative transcripts):

NM_001015051.3 NM_001024630.3 NM_004348.3

Unigene Cluster for RUNX2:

Runt-related transcription factor 2

Hs.535845 [show with all ESTs]

Unigene Representative Sequence: NM_004348

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000483377 ENST00000483243(uc003oxs.1) ENST00000465038 ENST00000371438(uc011dvx.2 uc011dvy.2)

ENST00000371436 ENST00000576263 ENST00000473041 ENST00000478660 ENST00000359524

ENST00000352853 ENST00000541979 ENST00000371432(uc003oxt.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): RUNX2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RUNX2
		8/63 QIAGEN miScript miRNA Assays for microRNAs that regulate RUNX2 (see all 63):
		hsa-miR-607 hsa-miR-302d hsa-miR-520e hsa-miR-485-3p hsa-miR-30d hsa-miR-519a hsa-miR-218 hsa-miR-4275

		SwitchGear 3'UTR luciferase reporter plasmid: RUNX2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RUNX2 (see all 4) OriGene shRNA RFP: RUNX2 OriGene siRNA: RUNX2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RUNX2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RUNX2 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RUNX2 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): RUNX2 (NM_001024630)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RUNX2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUNX2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RUNX2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RUNX2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RUNX2
		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RUNX2

Additional cDNA sequence:

AF053952.1 AF087960.1 AL353944.1 BC108919.1 BC108920.1 L40992.1

7 DOTS entries:

DT.95361643 DT.40189380 DT.208720 DT.121388720 DT.99997401 DT.40125005 DT.40125006

11 AceView cDNA sequences:

BX108677 AF053952 AW469546 AW850703 AW592551 AI738968 AA970073 AI394663

AW296595 AA779817 AW023513

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RUNX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

RUNX2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/109 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 109)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Autopod Epiphyseal End

Chondrocytes

Selective marker (cell-identifying gene)

Bone, Cartilage

Bone

Autopod Growth Plate

Hypertrophic Chondrocytes

Bone, Cartilage

Bone

Autopod Growth Plate

Prehypertrophic Chondrocytes

Bone, Cartilage

Bone

Autopod Growth Plate

Terminal Chondrocytes

Bone, Cartilage

Bone

Autopod Perichondrium

Endochondral Preosteoblasts

Bone

Autopod Periosteum

Endochondral Osteoblasts

Bone

Autopod Periosteum

Immature Endochondral Osteoblasts

Bone

Caudal Endochondral Bones

Endochondral Osteoblasts

Bone

Caudal Endochondral Bones

Endochondral Preosteoblasts

Bone

Caudal Endochondral Bones

Hypertrophic Chondrocytes

Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/11 LifeMap Cells (see all 11)

Name

Category

Mesenchymal Precursor Cells (STRO-3 selected) (Adult Stem / Progenitor Cell)

Bone

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

Chondrocyte-like cells (Direct differentiati...)

Bone, Cartilage

Mesoderm-like cells (Direct differentiati...)

Mesoderm

Mesendoderm cells (Generation of skelet...)

Connective tissue progenitor cells (Generation of connec...)

See RUNX2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RUNX2

SOURCE GeneReport for Unigene cluster: Hs.535845

UniProtKB/Swiss-Prot: RUNX2_HUMAN, Q13950

Tissue specificity: Specifically expressed in osteoblasts

SABiosciences Expression via Pathway-Focused PCR Arrays including RUNX2 (see all 8):

Osteogenesis in human mouse rat

Stem Cell Transcription Factors in human mouse rat

Leukemia in human mouse rat

Notch Signaling Targets in human mouse rat

Hedgehog Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RUNX2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RUNX2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RUNX2
		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RUNX2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUNX2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RUNX2 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Runx2^{1 , 5}	runt related transcription factor 2^{1, 5}	93.92(n)¹ 98.85(a)¹		17 (21.33 cM)⁵ 12393¹ NM_001146038.1¹ NP_001139510.1¹ 44495987⁵
chicken (Gallus gallus)	Aves	RUNX2¹	runt-related transcription factor 2	88.06(n) 97.03(a)		373919 NM_204128.1 NP_989459.1
lizard (Anolis carolinensis)	Reptilia	RUNX2⁶	--	94(a)	1 ↔ 1	1(138869690-139054248)
zebrafish (Danio rerio)	Actinopterygii	runx2a¹	runt-related transcription factor 2a	76.86(n) 88.43(a)		405784 NM_212858.2 NP_998023.1
fruit fly (Drosophila melanogaster)	Insecta	lz³	antennal morphogenesis transcription factor	76(a) (best of 4)		1 8D12 --
worm (Caenorhabditis elegans)	Secernentea	rnt-1¹	Protein RNT-1	41.17(n) 37.54(a)		172243 NM_059278.4 NP_491679.1

ENSEMBL Gene Tree for RUNX2 (if available)
TreeFam Gene Tree for RUNX2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RUNX2 gene

RUNX1² RUNX3²

5 SIMAP similar genes for RUNX2 using alignment to 9 protein entries: RUNX2_HUMAN (see all proteins):

RUNX1/C20orf112 fusion C20orf112/RUNX1 fusion RUNX1 RUNX3 RUNX1/CBFA2T2 fusion

RUNX2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs104893994^1,2	C	pathogenic	69297776(+)	`ATATTC/GAAATT`	6	S *	stop-lost		0	--	--	--	--
rs104893988^1,2	C	pathogenic	69333257(+)	`CCGTGA/GTCCTA`	6	* W	stg¹		0	--	--	--	--
rs104893991^1,2	C	pathogenic	69407499(+)	`ACCTCA/GGGAAC`	6	Q R	mis¹		0	--	--	--	--
rs104893992^1,2	C	pathogenic	69407500(+)	`GACCTC/TGGGAA`	6	R W	mis¹		0	--	--	--	--
rs104893993^1,2	C	pathogenic	69407575(+)	`CCTTGA/GCCATA`	6	T A	mis¹		0	--	--	--	--
rs104893989^1,2	C	pathogenic	69413576(+)	`TGTTAG/TGAAAA`	6	R M	mis¹		0	--	--	--	--
rs104893995^1,2	C	pathogenic	69413594(+)	`GCTCCC/GGAATG`	6	P R	mis¹		0	--	--	--	--
rs12201555^1,2	C,F,H,	--	45017084(+)	`ACCAGT/AGTATT`	2	--	us2k¹		7		NS EA WA NA	744
rs73735372^1,2	C,	--	45017560(+)	`GGAGAC/TAGTTT`	2	--	us2k¹		1		WA	2
rs74579060^1,2	F,	--	45017688(+)	`CTTCCA/CTTAGA`	2	--	us2k¹		1		NA	120

HapMap Linkage Disequilibrium report for RUNX2 (45295894 - 45545894 bp, first 250kb of RUNX2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RUNX2
1 CNV: 99524
Human Gene Mutation Database (HGMD): RUNX2

SABiosciences Cancer Mutation PCR Assays

1 SABiosciences qBiomarker Copy Number PCR Array containing RUNX2:

Birth Defects

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RUNX2

DNA2.0 Custom Variant and Variant Library Synthesis for RUNX2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RUNX2 for disorders           About GeneDecksing

OMIM gene information: 600211
OMIM disorders: 119600
UniProtKB/Swiss-Prot: RUNX2_HUMAN, Q13950

Defects in RUNX2 are the cause of cleidocranial dysplasia (CLCD) [MIM:119600]; also known as cleidocranial

dysostosis (CCD). CLCD is an autosomal dominant skeletal disorder with high penetrance and variable expressivity. It

is due to defective endochondral and intramembranous bone formation. Typical features include hypoplasia/aplasia of

clavicles, patent fontanelles, wormian bones (additional cranial plates caused by abnormal ossification of the

calvaria), supernumerary teeth, short stature, and other skeletal changes. In some cases defects in RUNX2 are

exclusively associated with dental anomalies

20/66 diseases for RUNX2 (see all 66): About MalaCards

cleidocranial dysplasia acute myeloid leukemia dental anomalies, isolated myeloid leukemia

saethre-chotzen syndrome craniofacial anomalies williams-beuren syndrome ossifying fibroma

craniofacial abnormalities fibrous dysplasia leukemia tooth agenesis

hyperphosphatemia short stature acrocephalosyndactylia pfeiffer syndrome

secondary hyperparathyroidism arterial calcification osteopetrosis osteolysis

5 diseases from the University of Copenhagen DISEASES database for RUNX2:

Cleidocranial dysplasia Osteoporosis Craniosynostosis Osteoarthritis

Cancer

10/44 Novoseek disease relationships for RUNX2 gene (see all 44) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cleidocranial dysplasia	95	71	11321595 (2), 11459326 (2), 16270353 (2), 19515746 (2) (see all 52)
supernumerary teeth	74.4	2	17973689 (1), 10521292 (1)
calcification	70.9	50	18378684 (4), 17538568 (3), 11684076 (2), 16837922 (2) (see all 37)
osteosarcoma	64	42	19739101 (5), 19688969 (5), 19894220 (3), 20465837 (3) (see all 19)
skeletal dysplasia	63.2	4	15952089 (1), 9434946 (1), 18424451 (1), 20014132 (1)
osteoporosis	58.4	11	18755791 (1), 16901655 (1), 19877060 (1), 12638206 (1) (see all 10)
bone diseases	56.4	14	17725488 (1), 18829534 (1), 19915614 (1), 17165130 (1) (see all 12)
osteolytic	50.2	11	15231660 (3), 17165130 (2), 15665096 (2), 18829534 (1) (see all 5)
ossification heterotopic	48.7	5	19940863 (4), 19543517 (1)
skeletal disorder	47.5	5	17290219 (1), 12682904 (1), 19734454 (1), 9182764 (1)

GeneTests: RUNX2

Cleidocranial Dysplasia

Genetic Association Database (GAD): RUNX2
Human Genome Epidemiology (HuGE) Navigator: RUNX2 (23 documents)

Export disorders for RUNX2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RUNX2 gene, integrated from 9 sources (see all 848):
(articles sorted by number of sources associating them with RUNX2)

Utopia: connect your pdf to the dynamic
world of online information

Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. (PubMed id 16407259)^{1, 2, 9} Qiao M....Passaniti A. (2006)
Four novel RUNX2 mutations including a splice donor site result in the cleidocranial dysplasia phenotype. (PubMed id 16270353)^{1, 2, 9} Kim H.J....Choi J.Y. (2006)
MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2. (PubMed id 11965546)^{1, 2, 9} Pelletier N.... Yang X.-J. (2002)
Functional analysis of RUNX2 mutations in Japanese patients with cleidocranial dysplasia demonstrates novel genotype-phenotype correlations. (PubMed id 12196916)^{1, 2, 9} Yoshida T....Shigesada K. (2002)
Variation in femoral length is associated with polymorphisms in RUNX2 gene. (PubMed id 16198163)^{1, 4, 9} Ermakov S....Livshits G. (2006)
A novel RUNX2 mutation (T420I) in Chinese patients wi th cleidocranial dysplasia. (PubMed id 20082269)^{1, 2, 9} Wang G.X....Song F.L. (2010)
RUNX2 mutations in cleidocranial dysplasia patients. (PubMed id 19744171)^{1, 2, 9} Ryoo H.M....Kim J.W. (2010)
Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex. (PubMed id 12145306)^{1, 2, 9} Willis D.M.... Towler D.A. (2002)
Alleles of RUNX2/CBFA1 gene are associated with differences in bone mineral density and risk of fracture. (PubMed id 12162506)^{1, 4, 9} Vaughan T....Morrison N.A. (2002)
Mutations in the RUNX2 gene in patients with cleidocranial dysplasia. (PubMed id 11857736)^{1, 2, 9} Otto F....Mundlos S. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 860	HGNC: 10472	AceView: RUNX2.1	Ensembl:ENSG00000124813	euGenes: HUgn860
ECgene: RUNX2	H-InvDB: RUNX2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RUNX2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RUNX2	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/RUNX2

Intellectual Property for RUNX2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RUNX2 gene:
Search GeneIP for patents involving RUNX2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Small Molecules at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of RUNX2

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for RUNX2 (RUNX2/CBFA1)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays for RUNX2 (RUNX2/CBFA1)
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for RUNX2		OriGene shRNA RFP for RUNX2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RUNX2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RUNX2
	OriGene Protein Over-expression Lysate for RUNX2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for RUNX2		OriGene 3'-UTR Clone for RUNX2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RUNX2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RUNX2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for RUNX2		OriGene Custom Protein Services for RUNX2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RUNX2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RUNX2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RUNX2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RUNX2
	Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RUNX2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RUNX2

	GenScript Custom Purified and Recombinant Proteins Services for RUNX2		GenScript cDNA clones with any tag delivered in your preferred vector for RUNX2
	GenScript Custom Assay Services for RUNX2		GenScript Custom Superior Antibodies Services for RUNX2
	GenScript Custom overexpressing Cell Line Services for RUNX2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for RUNX2 (AML3)

	Regulatory tfbs in RUNX2 promoter
	Search Chromatin IP Primers for RUNX2
	RT² qPCR Primer Assay in human, mouse, rat RUNX2
	GNC Network for RUNX2
	SABiosciences PCR Arrays including human, mouse, rat RUNX2

Search Tocris compounds for RUNX2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	RUNX2 antibodies
	RUNX2 proteins
	RUNX2 lysates

	Antibodies for RUNX2
	See all of Abcam's Antibodies, Kits and Proteins for RUNX2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

RUNX2 Proteins, Antibodies, CLIAs, and ELISAs

Cell Lines associated with RUNX2: PureStem SK11, NCr-fac & Meso-prx Progenitor,
PureStem SM30, NCr-fac & Meso-latp Progenitor

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUNX2

	SwitchGear 3'UTR luciferase reporter plasmids for RUNX2
	SwitchGear Promoter luciferase reporter plasmids for RUNX2

ThermoFisher Antibodies for RUNX2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUNX2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RUNX2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

RUNX2 Gene

runt-related transcription factor 2

Aliases
for RUNX2 gene

Summaries
for RUNX2 gene

Genomic Views
for RUNX2 gene

Proteins
for RUNX2 gene

Protein Domains /
Families
for RUNX2 gene

Function
for RUNX2 gene

Pathways & Interactions
for RUNX2 gene

Drugs & Compounds
for RUNX2 gene

Transcripts
for RUNX2 gene

Expression
for RUNX2 gene

Orthologs
for RUNX2 gene

Paralogs
for RUNX2 gene

Genomic Variants
for RUNX2 gene

Disorders / Diseases
for RUNX2 gene

Publications
for RUNX2 gene

External Searches for RUNX2 gene

Genome Databases showing RUNX2 gene

Other Databases showing RUNX2 gene

Specialized Databases showing RUNX2 gene

Intellectual Property
for RUNX2 gene

Products
for RUNX2 gene

View Random Gene

RUNX2 (Gene Symbol)
Runt-Related Transcription Factor 2
AML3
CBFA1
PEBP2A1
CCD
CCD1
PEBP2aA1
Acute Myeloid Leukemia 3 Protein
Oncogene AML-3
Osteoblast-Specific Transcription Factor 2
Polyomavirus Enhancer-Binding Protein 2 Alpha A Subunit
CBF-Alpha-1
OSF-2
OSF2
PEA2-Alpha A
PEBP2-Alpha A
SL3-3 Enhancer Factor 1 Alpha A Subunit
SL3/AKV Core-Binding Factor Alpha A Subunit
PEA2aA
PEBP2A2
PEBP2aA
Core-Binding Factor, Runt Domain, Alpha Subunit 1
PEBP2A
Core-Binding Factor Subunit Alpha-1

Ossification Heterotopic
Osteopetrosis
Gastric Cancer
Chondrosarcoma
Retinoblastoma
craniofacial anomaly
Skeletal dysplasia
BONE TUMOR
dysplasia
Carcinoma
Aplasia
Osteoarthritis
Leukemia
Bone Diseases
Breast Cancer
Osteosarcoma
Osteoporosis
Calcification
Supernumerary teeth
Cancer
Lymphoma
HYPERPHOSPHATEMIA
Hypoplasia
Cleidocranial Dysplasia
Shock
Osteolysis
Inflammation
BRACHYDACTYLY
osteolytic
skeletal disorder
Hyperglycemia
Hypertrophy
Rheumatoid Arthritis
prostate cancer
Tumors
FIBROUS DYSPLASIA
Metastasis
Necrosis
genetic disorder
breast cancer metastatic
Growth retardation
Collagen fibril
Bone Diseases Metabolic
Renal Failure Chronic

Advanced Search

Export list of displayed genes

RUNX2 Gene

runt-related transcription factor 2

Aliasesfor RUNX2 gene

Summariesfor RUNX2 gene

Genomic Viewsfor RUNX2 gene

Proteinsfor RUNX2 gene

Protein Domains /Familiesfor RUNX2 gene

Functionfor RUNX2 gene

Pathways & Interactionsfor RUNX2 gene

Drugs & Compoundsfor RUNX2 gene

Transcriptsfor RUNX2 gene

Expression for RUNX2 gene

Orthologsfor RUNX2 gene

Paralogsfor RUNX2 gene

Genomic Variantsfor RUNX2 gene

Disorders / Diseasesfor RUNX2 gene

Publicationsfor RUNX2 gene

External Searches for RUNX2 gene

Genome Databases showing RUNX2 gene

Other Databases showing RUNX2 gene

Specialized Databases showing RUNX2 gene

Intellectual Propertyfor RUNX2 gene

Productsfor RUNX2 gene

View Random Gene

Aliases
for RUNX2 gene

Summaries
for RUNX2 gene

Genomic Views
for RUNX2 gene

Proteins
for RUNX2 gene

Protein Domains /
Families
for RUNX2 gene

Function
for RUNX2 gene

Pathways & Interactions
for RUNX2 gene

Drugs & Compounds
for RUNX2 gene

Transcripts
for RUNX2 gene

Expression
for RUNX2 gene

Orthologs
for RUNX2 gene

Paralogs
for RUNX2 gene

Genomic Variants
for RUNX2 gene

Disorders / Diseases
for RUNX2 gene

Publications
for RUNX2 gene

Intellectual Property
for RUNX2 gene

Products
for RUNX2 gene