Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RUNX1T1 Gene

protein-coding   GIFtS: 59
GCID: GC08M092971

Runt-Related Transcription Factor 1; Translocated To, 1...

(Previous names: core-binding factor, runt domain, alpha subunit 2; translocated...)
(Previous symbols: AML1T1, CBFA2T1)
  See RUNX1T1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Runt-Related Transcription Factor 1; Translocated To, 1 (Cyclin
D-Related)1 2
     CBFA2T1 Isoform R1t1-7a492
AML1T11 2 3 5     CBFA2T1 Isoform R1t1-7a502
CBFA2T11 2 3 5     CBFA2T1 Isoform R1t1-7a522
ETO2 3 5     CBFA2T1 Isoform R1t1-7d532
Core-Binding Factor, Runt Domain, Alpha Subunit 2; Translocated To, 1;
Cyclin D-Related1 2
     CBFA2T1 Isoform R1t1-7d542
Eight Twenty One Protein2 3     CBFA2T1 Isoform R1t1-7d552
Zinc Finger MYND Domain-Containing Protein 22 3     CBFA2T1 Isoform R1t1-7d562
CDR2 3     CBFA2T1 Isoform R1t1-8a572
MTG82 3     CBFA2T1 Isoform R1t1-8a582
ZMYND22 3     CBFA2T1 Isoform R1t1-8a592
Acute Myelogenous Leukemia 1 Translocation 1, Cyclin-D Related2     CBFA2T1 Isoform R1t1-8a602
CBFA2T1 Isoform R1t1-11a622     Myeloid Translocation Gene On 8q222
CBFA2T1 Isoform R1t1-11a632     Protein CBFA2T12
CBFA2T1 Isoform R1t1-11a642     Cyclin-D-Related Protein3
CBFA2T1 Isoform R1t1-11a652     Protein ETO3
CBFA2T1 Isoform R1t1-7a472     Protein MTG83
CBFA2T1 Isoform R1t1-7a482     

External Ids:    HGNC: 15351   Entrez Gene: 8622   Ensembl: ENSG000000791027   OMIM: 1334355   UniProtKB: Q064553   

Export aliases for RUNX1T1 gene to outside databases

Previous GC identifers: GC08M093041 GC08M088178


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RUNX1T1 Gene:
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription
factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22)
translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation
produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the
3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone
deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Nov 2010)

GeneCards Summary for RUNX1T1 Gene:
RUNX1T1 (runt-related transcription factor 1; translocated to, 1 (cyclin D-related)) is a protein-coding gene. Diseases associated with RUNX1T1 include acute myeloid leukemia with t(8;21)(q22;q22) translocation, and refractory anemia. GO annotations related to this gene include identical protein binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is DEAF1.

UniProtKB/Swiss-Prot: MTG8_HUMAN, Q06455
Function: Transcription regulator that excerts its function by binding to histone deacetylases and transcription
factors. Can repress transactivation mediated by TCF12

Gene Wiki entry for RUNX1T1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RUNX1T1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRUNX1T1 promoter sequence
   Search Chromatin IP Primers for RUNX1T1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RUNX1T1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22   Ensembl cytogenetic band:  8q21.3   HGNC cytogenetic band: 8q22

RUNX1T1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RUNX1T1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M092971:  view genomic region     (about GC identifiers)

Start:
92,967,195 bp from pter      End:
93,115,514 bp from pter
Size:
148,320 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MTG8_HUMAN, Q06455 (See protein sequence)
Recommended Name: Protein CBFA2T1  
Size: 604 amino acids; 67566 Da
Subunit: Homotetramer. Heterotetramer with CBFA2T2 and CBFA2T3. Interacts with TCF12, SIN3A, HDAC1, HDAC2, HDAC3,
NCOR1 and NCOR2. Interacts with ATN1 (via its N-terminus); the interaction enhances the transcriptional
repression
Sequence caution: Sequence=AAH05850.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA03247.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Selected PDB 3D structures from and Proteopedia for RUNX1T1 (see all 9):
1WQ6 (3D)        2DJ8 (3D)        2H7B (3D)        2KNH (3D)        2KYG (3D)        2OD1 (3D)    
Secondary accessions: B7Z4P4 E7EPN4 O14784 Q06456 Q14873 Q16239 Q16346 Q16347 Q6IBL1 Q6NXH1
Q7Z4J5 Q92479 Q9BRZ0
Alternative splicing: 4 isoforms:  Q06455-1   Q06455-2   Q06455-3   Q06455-4   

Explore the universe of human proteins at neXtProt for RUNX1T1: NX_Q06455

Explore proteomics data for RUNX1T1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RUNX1T1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (15 alternative transcripts): 
    NP_001185554.1  NP_001185555.1  NP_001185556.1  NP_001185557.1  NP_001185558.1  NP_001185559.1  NP_001185560.1  NP_001185561.1  
    NP_001185562.1  NP_001185563.1  NP_001185608.1  NP_004340.1  NP_783552.1  NP_783553.1  NP_783554.1  

    ENSEMBL proteins: 
     ENSP00000428543   ENSP00000379520   ENSP00000353504   ENSP00000390137   ENSP00000428742  
     ENSP00000430728   ENSP00000430778   ENSP00000429085   ENSP00000430863   ENSP00000429728  
     ENSP00000431094   ENSP00000427763   ENSP00000430204   ENSP00000429940   ENSP00000429532  
     ENSP00000429506   ENSP00000430637   ENSP00000428100   ENSP00000429137   ENSP00000430070  
     ENSP00000429118   ENSP00000430084   ENSP00000428475   ENSP00000429653   ENSP00000429062  
     ENSP00000429666   ENSP00000429587   ENSP00000429034   ENSP00000429375   ENSP00000429864  
     ENSP00000428297   ENSP00000430080   ENSP00000430334   ENSP00000429857   ENSP00000428408  
     ENSP00000428133   ENSP00000402257   ENSP00000265814  

    RUNX1T1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for RUNX1T1
    OriGene Protein Over-expression Lysate for RUNX1T1
    OriGene MassSpec for RUNX1T1
    OriGene Custom Protein Services for RUNX1T1
    GenScript Custom Purified and Recombinant Proteins Services for RUNX1T1
    Novus Biologicals RUNX1T1 Proteins
    Novus Biologicals RUNX1T1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RUNX1T1

     
    Search eBioscience for Proteins for RUNX1T1 

     
    antibodies-online proteins for RUNX1T1 (4 products) 

     
    antibodies-online peptides for RUNX1T1

    RUNX1T1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for RUNX1T1 
    OriGene Antibodies for RUNX1T1
    OriGene Custom Antibody Services for RUNX1T1
    Novus Biologicals RUNX1T1 Antibodies
    Abcam antibodies for RUNX1T1
    Cloud-Clone Corp. Antibodies for RUNX1T1
    Search ThermoFisher Antibodies for RUNX1T1
    antibodies-online antibodies for RUNX1T1 (35 products) 

    RUNX1T1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RUNX1T1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RUNX1T1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RUNX1T1
    Cloud-Clone Corp. CLIAs for RUNX1T1
    Search eBioscience for ELISAs for RUNX1T1 
    antibodies-online kits for RUNX1T1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ZMYND: Zinc fingers, MYND-type

    5 InterPro protein domains:
     IPR002893 Znf_MYND
     IPR014896 NHR2
     IPR013290 MTG8
     IPR013289 ETO
     IPR003894 TAFH_NHR1

    Graphical View of Domain Structure for InterPro Entry Q06455

    ProtoNet protein and cluster: Q06455

    2 Blocks protein domains:
    IPB002893 Zn-finger
    IPB003894 TAF-like region


    UniProtKB/Swiss-Prot: MTG8_HUMAN, Q06455
    Domain: The TAFH domain mediates interaction with transcription regulators
    Similarity: Belongs to the CBFA2T family
    Similarity: Contains 1 MYND-type zinc finger
    Similarity: Contains 1 TAFH (NHR1) domain


    Find genes that share domains with RUNX1T1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTG8_HUMAN, Q06455
    Function: Transcription regulator that excerts its function by binding to histone deacetylases and transcription
    factors. Can repress transactivation mediated by TCF12

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI10973986
    GO:0042802identical protein binding IPI16616331
    GO:0042803protein homodimerization activity IEA--
         
    Find genes that share ontologies with RUNX1T1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RUNX1T1:
     Increased G2M DNA content 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Runx1t1):
     behavior/neurological  cardiovascular system  digestive/alimentary  growth/size/body  integument 
     mortality/aging  normal  reproductive system 

    Find genes that share phenotypes with RUNX1T1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RUNX1T1

    miRNA
    Products:
        
    miRTarBase miRNAs that target RUNX1T1:
    hsa-mir-16-5p (MIRT031791), hsa-mir-103a-3p (MIRT027124), hsa-mir-106b-5p (MIRT020443), hsa-let-7e-5p (MIRT051459)

    Block miRNA regulation of human, mouse, rat RUNX1T1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RUNX1T1 (see all 285):
    hsa-miR-579 hsa-miR-193a-3p hsa-miR-146a hsa-miR-605 hsa-miR-502-3p hsa-miR-3916 hsa-miR-3162-5p hsa-miR-1273d
    SwitchGear 3'UTR luciferase reporter plasmidRUNX1T1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RUNX1T1
    Predesigned siRNA for gene silencing in human, mouse, rat RUNX1T1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RUNX1T1

    Clone
    Products:
         
    OriGene clones in human, mouse for RUNX1T1 (see all 34)
    OriGene ORF clones in mouse, rat for RUNX1T1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 15): RUNX1T1 (NM_004349)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RUNX1T1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUNX1T1
    Addgene plasmids for RUNX1T1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RUNX1T1
    Browse ESI BIO Cell Lines and PureStem Progenitors for RUNX1T1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUNX1T1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MTG8_HUMAN, Q06455: Nucleus. Note=Colocalizes with ATN1 in discrete nuclear dots
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion3
    extracellular2
    cytosol1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0016363nuclear matrix IDA10973986

    Find genes that share ontologies with RUNX1T1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RUNX1T1 About    
    See pathways by source

    SuperPathContained pathways About
    1Endometrial cancer
    Acute myeloid leukemia0.40
    2Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    3Pathways in cancer
    Pathways in cancer
    4Lymphocyte Signaling
    Lymphocyte Signaling


    Find genes that share SuperPaths with RUNX1T1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for RUNX1T1
        Lymphocyte Signaling


    3 Kegg Pathways  (Kegg details for RUNX1T1):
        Pathways in cancer
    Transcriptional misregulation in cancer
    Acute myeloid leukemia

        Pathway & Disease-focused RT2 Profiler PCR Array including RUNX1T1: 
              Adipogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RUNX1T1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RUNX1T1 (Q064551, 2, 3 ENSP000002658144) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATN1P542592, 3, ENSP000003490764MINT-2857407 I2D: score=4 STRING: ENSP00000349076
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2857388 I2D: score=3 STRING: ENSP00000357292
    TCF12Q990813, ENSP000003310574I2D: score=6 STRING: ENSP00000331057
    ABI3Q9P2A43, ENSP000002259414I2D: score=4 STRING: ENSP00000225941
    HDAC3O153793, ENSP000003029674I2D: score=4 STRING: ENSP00000302967
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy TAS9618262
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0045444fat cell differentiation IEA--
    GO:0051101regulation of DNA binding IEA--

    Find genes that share ontologies with RUNX1T1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RUNX1T1 (MTG8)

    5 Novoseek inferred chemical compound relationships for RUNX1T1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 32.2 9 15109542 (2), 8334990 (1), 15377655 (1), 7812194 (1) (see all 6)
    proline 3.33 2 7812194 (1)
    oligonucleotide 0 1 8499624 (1)
    threonine 0 3 10076566 (2), 8781439 (1)
    serine 0 3 10076566 (2), 8781439 (1)



    Find genes that share compounds with RUNX1T1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RUNX1T1 gene (15 alternative transcripts): 
    NM_001198625.1  NM_001198626.1  NM_001198627.1  NM_001198628.1  NM_001198629.1  NM_001198630.1  NM_001198631.1  NM_001198632.1  
    NM_001198633.1  NM_001198634.1  NM_001198679.1  NM_004349.3  NM_175634.2  NM_175635.2  NM_175636.2  

    Unigene Cluster for RUNX1T1:

    Runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
    Hs.368431  [show with all ESTs]
    Unigene Representative Sequence: NM_001198625
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 47):
    ENST00000523629(uc010man.2 uc003yfb.2 uc003yfc.2 uc010mam.3 uc003yfe.2 uc003yfd.3 uc022axo.1 uc010mao.3 uc011lgi.2 uc022axp.1 uc022axq.1 uc022axr.1 uc022axs.1 uc022axt.1 uc022axu.1 uc022axv.1)
    ENST00000396218 ENST00000360348 ENST00000422361(uc003yfg.2) ENST00000520724
    ENST00000521078 ENST00000518844 ENST00000521751 ENST00000520978 ENST00000518361
    ENST00000520047 ENST00000521553(uc003yff.1) ENST00000522316 ENST00000518992
    ENST00000521054 ENST00000523290 ENST00000519847 ENST00000517792
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RUNX1T1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RUNX1T1 (see all 285):
    hsa-miR-579 hsa-miR-193a-3p hsa-miR-146a hsa-miR-605 hsa-miR-502-3p hsa-miR-3916 hsa-miR-3162-5p hsa-miR-1273d
    SwitchGear 3'UTR luciferase reporter plasmidRUNX1T1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RUNX1T1
    Predesigned siRNA for gene silencing in human, mouse, rat RUNX1T1
    Clone
    Products:
         
    OriGene clones in human, mouse for RUNX1T1 (see all 34)
    OriGene ORF clones in mouse, rat for RUNX1T1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 15): RUNX1T1 (NM_004349)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RUNX1T1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUNX1T1
    Addgene plasmids for RUNX1T1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RUNX1T1
    OriGene qSTAR qPCR primer pairs in human, mouse for RUNX1T1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RUNX1T1
      QuantiTect SYBR Green Assays in human, mouse, rat RUNX1T1
      QuantiFast Probe-based Assays in human, mouse, rat RUNX1T1

    Additional mRNA sequence: 

    AF018283.1 AF131817.1 AK297616.1 AK312592.1 AL049240.1 BC005850.1 BC067078.1 BT009871.1 
    CR456792.1 D14289.1 D14821.1 D43638.1 S82690.1 X79990.1 Z35296.1 

    Selected DOTS entries (see all 27):

    DT.95267502  DT.121484056  DT.95267501  DT.95267503  DT.92474135  DT.92474122  DT.65285691  DT.121484123 
    DT.121484036  DT.121484082  DT.121484113  DT.300587  DT.92474131  DT.121484027  DT.121484088  DT.215536 
    DT.100023769  DT.121484092  DT.121484105  DT.95207072  DT.121484035  DT.121484103  DT.121484135  DT.406088 

    Selected AceView cDNA sequences (see all 83):

    NM_175636 NM_175635 H46979 NM_004349 AL599454 AI264845 BT009871 AI804854 
    N75054 CA844294 AA904353 BQ632275 BC067078 AU117637 AK057707 CA844355 
    H94855 CR619328 H80492 AA992855 F02579 AL536357 CA848975 X79990 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RUNX1T1 (see all 26)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10a · 10b ·
    SP1:                                                                          -     -     -     -     -     -     -     -                                       
    SP2:                                                        -     -     -     -     -     -     -     -     -     -     -                                       
    SP3:                                                                                                        -     -     -                                       
    SP4:                                                                                                                                                            
    SP5:                                -     -     -           -                 -     -     -     -     -     -     -     -                                       

    ExUns: 10c · 10d · 10e · 10f · 10g ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
    SP1:                                      -                 -                                             
    SP2:                                      -                 -                                             
    SP3:                                      -                 -                                             
    SP4:                                      -                 -                                             
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for RUNX1T1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RUNX1T1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTTGTCAG
    RUNX1T1 Expression
    About this image


    RUNX1T1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Pancreas (Endocrine System)    fully expand to see all 4 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Cells Ureteric Bud
    RUNX1T1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RUNX1T1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368431

    UniProtKB/Swiss-Prot: MTG8_HUMAN, Q06455
    Tissue specificity: Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary

        Pathway & Disease-focused RT2 Profiler PCR Array including RUNX1T1: 
              Adipogenesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RUNX1T1
    OriGene qSTAR qPCR primer pairs in human, mouse for RUNX1T1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RUNX1T1
    QuantiTect SYBR Green Assays in human, mouse, rat RUNX1T1
    QuantiFast Probe-based Assays in human, mouse, rat RUNX1T1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUNX1T1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for RUNX1T1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Runx1t11 , 5 runt-related transcription factor 1; translocated to, more1, 5 91.9(n)1
    99.13(a)1
      4 (5.88 cM)5
    123951  NM_001111027.21  NP_001104497.11 
     137434365 
    chicken
    (Gallus gallus)
    Aves RUNX1T11 runt-related transcription factor 1; translocated to, more 89.29(n)
    96.87(a)
      395503  NM_204744.1  NP_990075.1 
    lizard
    (Anolis carolinensis)
    Reptilia RUNX1T16
    runt-related transcription factor 1; translocated ...
    94(a)
    1 ↔ 1
    4(17706169-17848839)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia runx1t11 runt-related transcription factor 1; translocated to, more 85.24(n)
    96.37(a)
      100491944  XM_002934415.2  XP_002934461.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj53h112 Transcribed sequence with strong similarity to protein more 78.35(n)    57077045 
    fruit fly
    (Drosophila melanogaster)
    Insecta nvy6
    nervy
    25(a)
    1 → many
    2R(20163258-20178607)


    ENSEMBL Gene Tree for RUNX1T1 (if available)
    TreeFam Gene Tree for RUNX1T1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RUNX1T1 gene
    DEAF12  CBFA2T32  CBFA2T22  
    4 SIMAP similar genes for RUNX1T1 using alignment to 26 protein entries:     MTG8_HUMAN (see all proteins):
    MTG8    CBFA2T2    RUNX1/CBFA2T2 fusion    CBFA2T3

    Find genes that share paralogs with RUNX1T1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RUNX1T1 (see all 2605)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363224
    A colorectal cancer sample4--see VAR_0363222 R W mis40--------
    VAR_0363234
    A colorectal cancer sample4--see VAR_0363232 A V mis40--------
    VAR_0363214
    A colorectal cancer sample4--see VAR_0363212 R W mis40--------
    rs38325641,2
    C--88176753(-) AAAAAA/-TCCCT 15 -- ut313Minor allele frequency- -:0.17NA 6
    rs354866851,2
    C--88210437(+) AAAAAT/-ATCAA 15 -- int13Minor allele frequency- -:0.17NA CSA 6
    rs680058401,2
    C--88210438(+) AAAAA-/TTCAAA 15 -- int10--------
    rs1119661171,2
    C,F--88246496(+) AAAAAG/CAAAAA 14 -- int11Minor allele frequency- C:0.50NA 2
    rs350946381,2
    C--88280232(+) TTGAT-/GAGAGAG 14 -- int10--------
    rs340447701,2
    C--92970968(+) AAAAA-/A/AA  
            
    AAAAA
    30 -- ut311NA 2
    rs588357521,2
    C--92971104(+) AAGAG-/AGTGAAA 15 -- ut310--------

    HapMap Linkage Disequilibrium report for RUNX1T1 (92967195 - 93115514 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RUNX1T1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv891193CNV Loss21882294

    Human Gene Mutation Database (HGMD): RUNX1T1
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing RUNX1T1:
    Prostate Cancer
    SeqTarget long-range PCR primers for resequencing RUNX1T1
    DNA2.0 Custom Variant and Variant Library Synthesis for RUNX1T1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 133435    OMIM disorders: --

    UniProtKB/Swiss-Prot: MTG8_HUMAN, Q06455
  • Note=A chromosomal aberration involving RUNX1T1 is a cause of acute myeloid leukemia (AML-M2).
    Translocation t(8;21)(q22;q22) with RUNX1/AML1
  • Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from
    the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with
    progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon
    and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The disease
    may be caused by mutations affecting the gene represented in this entry

  • 6 diseases for RUNX1T1:    
    About MalaCards
    acute myeloid leukemia with t(8;21)(q22;q22) translocation    refractory anemia    lipoprotein glomerulopathy    myeloid leukemia
    acute myeloid leukemia    leukemia

    1 disease from the University of Copenhagen DISEASES database for RUNX1T1:
    Leukemia

    Find genes that share disorders with RUNX1T1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for RUNX1T1 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemogenesis 78.5 2 10076566 (1), 8781439 (1)
    minimal residual disease 64 1 7553157 (1)
    leukemia 62.5 11 15723339 (2), 15231665 (1), 16893685 (1), 17572682 (1) (see all 8)
    chromosomal aberrations 55.7 2 15231665 (1), 8427996 (1)
    myeloid leukemia 54.6 2 17572682 (1), 10675041 (1)
    aml childhood 52.2 2 12557226 (1)
    hematologic malignancies 47.3 1 14551142 (1)
    promyelocytic leukemia 41.9 2 10688654 (1), 10951564 (1)
    acute leukemia 36.2 1 14551142 (1)
    leukemia promyelocytic acute 23.5 1 14551142 (1)

    Genetic Association Database (GAD): RUNX1T1

    Export disorders for RUNX1T1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RUNX1T1 gene, integrated from 10 sources (see all 204):
    (articles sorted by number of sources associating them with RUNX1T1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two transcripts of AML1/ETO-fused gene in t(8;21) leukemic cells and expression of wild-type ETO gene in hematopoietic cells. (PubMed id 7541640)1, 2, 9 Era T.... Takatsuki K. (Genes Chromosomes Cancer 1995)
    2. A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription. (PubMed id 17572682)1, 2, 9 Wei Y.... Werner M.H. (Nat. Struct. Mol. Biol. 2007)
    3. Structure and expression of the human MTG8/ETO gene. (PubMed id 9661669)1, 2, 9 Wolford J.K. and Prochazka M. (Gene 1998)
    4. CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family. (PubMed id 9790752)1, 3, 9 Calabi F. and Cilli V. (Genomics 1998)
    5. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. (PubMed id 8334990)1, 2, 9 Miyoshi H.... Ohki M. (EMBO J. 1993)
    6. Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells. (PubMed id 1423235)1, 2, 9 Nisson P.E.... Sacchi N. (Cancer Genet. Cytogenet. 1992)
    7. The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity. (PubMed id 16616331)1, 2 Liu Y....Bushweller J.H. (Cancer Cell 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t(16; 21)-positive myeloid malignancies. (PubMed id 12242670)1, 2 Hoogeveen A.T.... Sacchi N. (Oncogene 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 862 HGNC: 1535 AceView: CBFA2T1 Ensembl:ENSG00000079102 euGenes: HUgn862
    ECgene: RUNX1T1 Kegg: 862 H-InvDB: RUNX1T1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RUNX1T1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RUNX1T1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RUNX1T1 gene:
    Search GeneIP for patents involving RUNX1T1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RUNX1T1   OriGene RNAi products in human, mouse, rat for RUNX1T1  
     OriGene qPCR primer pairs and template standards for RUNX1T1   OriGene Protein Over-expression Lysate for RUNX1T1  
     OriGene MassSpec for RUNX1T1   OriGene clones in human, mouse for RUNX1T1  
     OriGene qSTAR qPCR primer pairs in human, mouse for RUNX1T1   OriGene Purified Protein for RUNX1T1  
     OriGene ORF clones in mouse, rat for RUNX1T1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RUNX1T1   OriGene Custom Protein Services for RUNX1T1  

     
     
     Block miRNA regulation of human, mouse, rat RUNX1T1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RUNX1T1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RUNX1T1 Predesigned siRNA for gene silencing in human, mouse, rat RUNX1T1
     QuantiFast Probe-based Assays in human, mouse, rat RUNX1T1 QuantiTect SYBR Green Assays in human, mouse, rat RUNX1T1
     PCR Arrays including human, mouse, rat RUNX1T1 Search Chromatin IP Primers for RUNX1T1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RUNX1T1  GeneGlobe Interaction Network for RUNX1T1
     Regulatory tfbs in RUNX1T1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RUNX1T1 GenScript cDNA clones with any tag delivered in your preferred vector for RUNX1T1
     GenScript Custom Assay Services for RUNX1T1 GenScript Custom overexpressing Cell Line Services for RUNX1T1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for RUNX1T1 

     Search Tocris compounds for RUNX1T1 (MTG8)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RUNX1T1 antibodies
     RUNX1T1 proteins
     RUNX1T1 lysates
     Antibodies for RUNX1T1
     See all of Abcam's Antibodies, Kits and Proteins for RUNX1T1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RUNX1T1
     Antibodies for RUNX1T1
     ELISAs for RUNX1T1
     CLIAs for RUNX1T1



     Browse ESI BIO Cell Lines and PureStem Progenitors for RUNX1T1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUNX1T1
     SwitchGear 3'UTR luciferase reporter plasmids for RUNX1T1
     SwitchGear Promoter luciferase reporter plasmids for RUNX1T1
     Search ThermoFisher Antibodies for RUNX1T1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUNX1T1
     Browse compounds at ApexBio
     Addgene plasmids for RUNX1T1
      Search eBioscience for proteins for RUNX1T1
      Search eBioscience for elisas for RUNX1T1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for RUNX1T1
     antibodies-online antibodies for RUNX1T1 (35 products)
     antibodies-online kits for RUNX1T1 (4 products)
     antibodies-online peptides for RUNX1T1
     antibodies-online proteins for RUNX1T1 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RUNX1T1 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4