RUNDC3B Gene
protein-coding GIFtS: 45
GCID: GC07P087256
|
|
RUN domain containing 3B
| |
Aliases
for RUNDC3B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RUN Domain Containing 3B1 2 | | Rap2-Binding Protein 92 3 | | RPIB91 2 3 | | Rap2-Interacting Protein 92 3 | | RPIP91 2 3 | | Rap2 Binding Protein 92 | | RPIP-92 3 | | RUN Domain-Containing Protein 3B2 |
Export aliases for RUNDC3B gene to outside databasesPrevious GC identifers: GC07P087096 GC07P081867 |
Summaries
for RUNDC3B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RUNDC3B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RUNDC3B gene promoter:
Sp1 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 E47 Egr-4 AREB6 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for RUNDC3B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RUNDC3B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q21.12 Ensembl cytogenetic band: 7q21.12 HGNC cytogenetic band: 7q21.12RUNDC3B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P087256: view genomic region
(about GC identifiers)
Start:
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87,256,864 bp from pter |
End:
|
87,461,613 bp from pter |
Size:
|
204,750 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 86,589,043-86,792,931 |
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Proteins
for RUNDC3B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RUN3B_HUMAN, Q96NL0 (See
protein sequence)Recommended Name: RUN domain-containing protein 3B Size: 473 amino acids; 52813 Da
Subunit: Interacts with RAP2A (By similarity)
Sequence caution: Sequence=AAH22520.1; Type=Frameshift; Positions=444;
Secondary accessions: B4DFD0 E9PBR4 Q8IWW5 Q8NB55 Q8TBG7Alternative splicing: 5 isoforms: Q96NL0-1 Q96NL0-2 Q96NL0-3 Q96NL0-4 Q96NL0-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RUNDC3B: NX_Q96NL0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96NL0
RUNDC3B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001127877.1 NP_001127878.1 NP_612147.1
ENSEMBL proteins: ENSP00000337732 ENSP00000420394 ENSP00000378149
Human Recombinant Protein Products:
RUNDC3B Antibody Products:
Assay Products for RUNDC3B: |
Protein
Domains /
Families
for RUNDC3B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RUNDC3B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96NL0ProtoNet protein and cluster: Q96NL0 UniProtKB/Swiss-Prot: RUN3B_HUMAN, Q96NL0Similarity: Belongs to the RUNDC3 familySimilarity: Contains 1 RUN domain |
Function
for RUNDC3B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RUNDC3B (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RUNDC3B (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): RUNDC3B (NM_001134406) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RUNDC3B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUNDC3B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUNDC3B |
|
Pathways & Interactions
for RUNDC3B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RUNDC3B
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
4 Interacting proteins for RUNDC3B (Q96NL02, 3 ENSP000003377324) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for RUNDC3B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RUNDC3B
Search CenterWatch for drugs/clinical trials and news about RUNDC3B / RUN3B
|
Transcripts
for RUNDC3B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RUNDC3B gene (3 alternative transcripts): NM_001134405.1 NM_001134406.1 NM_138290.2 Unigene Cluster for RUNDC3B: RUN domain containing 3B Hs.411488 [show with all ESTs]Unigene Representative Sequence: NM_1382909 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000466676 ENST00000497788 ENST00000338056(uc011khd.1 uc003ujb.3 uc011khe.2 uc003ujc.3 uc003ujd.3)
ENST00000476114 ENST00000493037 ENST00000394654 ENST00000489461 ENST00000312373
ENST00000496000
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RUNDC3B (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RUNDC3B (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): RUNDC3B (NM_001134406) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RUNDC3B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUNDC3B |
Additional cDNA sequence: AK055233.1 AK091536.1 AK293607.1 AK294039.1 AY033596.1 BC022520.1 4 DOTS entries: DT.91677869 DT.70100577 DT.40225540 DT.121112976 24/30 AceView cDNA sequences (see all 30): BM711085 AA576095 BM683546 BM681954 NM_138290 AK055233 AA566137 BC022520 BP349533 BX442224 AK091536 AX747043 BM718501 BX452186 BM543416 AY033596 AI377469 BP350020 BM729011 AI627179 D81985 H96468 AA566134 BF185433
GeneLoc Exon Structure
|
Expression
for RUNDC3B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RUNDC3B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RUNDC3B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RUNDC3B
SOURCE GeneReport for Unigene cluster: Hs.411488
UniProtKB/Swiss-Prot: RUN3B_HUMAN, Q96NL0Tissue specificity: Isoform 2 is expressed at high levels in brain, thymus, ovary, testis, leukocyte, liver, smallintestine and prostate. Isoform 1 is expressed in the brain, testis and adrenal gland. It is activated in tumorigenicbreast cancer cell lines and in the primary tumor of breast cancer patients. Activation also correlates withmetastatic lymph node invasion and can be detected in metastatic epithelial cells from the lymph nodes and in the bonemarrow of patients
SABiosciences Custom PCR Arrays for RUNDC3B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RUNDC3B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RUNDC3B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RUNDC3B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RUNDC3B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUNDC3B |
Orthologs
for RUNDC3B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RUNDC3B gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RUNDC3B1 |
RUN domain containing 3B |
82.11(n)
89.14(a) |
|
420535 NM_001030972.1 NP_001026143.1 |
lizard
(Anolis carolinensis) |
Reptilia |
RUNDC3B6 |
-- |
88(a) |
1 ↔ 1 |
6(19370711-19392126) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
MGC760822 |
hypothetical protein MGC76082 |
82.38(n) |
|
BC062503.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.284612 |
Danio rerio cDNA clone IMAGE5600149 |
76.4(n) |
|
BC058324.1 |
ENSEMBL Gene Tree for RUNDC3B (if available)
TreeFam Gene Tree for RUNDC3B (if available) |
Paralogs
for RUNDC3B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RUNDC3B gene
- RUFY22 RUNDC3A2 RUFY32 RUFY12
1 SIMAP similar gene for RUNDC3B using alignment to 1 protein entry: RUN3B_HUMAN:RUNDC3A
RUNDC3B for paralogs About GeneDecksing
|
Genomic Variants
for RUNDC3B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RUNDC3B (87256864 - 87461613 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for RUNDC3B
6 CNVs: 64878 82071 94660 94662 62688 94661 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RUNDC3B |
|
Disorders
/ Diseases
for RUNDC3B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RUNDC3B for disorders About GeneDecksing
5  diseases for RUNDC3B: About MalaCardsbreast carcinoma breast cancer carcinoma malaria
prostatitis
Human Genome Epidemiology (HuGE) Navigator: RUNDC3B (3 documents)
Export disorders for RUNDC3B gene to outside databases
|
Publications
for RUNDC3B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RUNDC3B gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with RUNDC3B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning, expression, and genomic structure of a novel human Rap2 interacting gene (RPIP9). (PubMed id 12645870)1, 2, 3, 9 Wang S.... Mao Y.-M. (2003)
- Expression of RPIP9 (Rap2 interacting protein 9) is activated in breast carcinoma and correlates with a poor prognosis. (PubMed id 15986426)1, 2, 9 Raguz S....Yague E. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- Dual regulation of P-glycoprotein expression by tricho statin A in cancer cell lines. (PubMed id 22846052)1 Balaguer T.M....Saceda M. (2012)
- Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared wit h bipolar disorder. (PubMed id 22688191)1 Bergen S.E....Sullivan P.F. (2012)
- Genome-wide association study identifies five new schi zophrenia loci. (PubMed id 21926974)1 (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
|
External Searches for RUNDC3B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RUNDC3B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RUNDC3B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RUNDC3B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RUNDC3B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RUNDC3B gene:
Search GeneIP for patents involving RUNDC3B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RUNDC3B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RUNDC3B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RUNDC3B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RUNDC3B | | | OriGene Protein Over-expression Lysate for RUNDC3B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RUNDC3B | | OriGene 3'-UTR Clone for RUNDC3B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RUNDC3B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RUNDC3B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RUNDC3B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RUNDC3B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RUNDC3B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RUNDC3B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RUNDC3B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RUNDC3B |
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| | | | Search Tocris compounds for RUNDC3B |
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 | | | RUNDC3B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUNDC3B |
|  |  |  | | | | ThermoFisher Antibodies for RUNDC3B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUNDC3B |
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