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Aliases for RUNDC3B Gene

Aliases for RUNDC3B Gene

  • RUN Domain Containing 3B 2 3 5
  • Rap2-Interacting Protein 9 3 4
  • Rap2-Binding Protein 9 3 4
  • RPIP-9 3 4
  • RPIB9 3 4
  • RPIP9 3 4
  • RUN Domain-Containing Protein 3B 3
  • Rap2 Binding Protein 9 3

External Ids for RUNDC3B Gene

Previous GeneCards Identifiers for RUNDC3B Gene

  • GC07P087096
  • GC07P087256
  • GC07P081867

Summaries for RUNDC3B Gene

GeneCards Summary for RUNDC3B Gene

RUNDC3B (RUN Domain Containing 3B) is a Protein Coding gene. An important paralog of this gene is RUNDC3A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RUNDC3B Gene

Genomics for RUNDC3B Gene

Regulatory Elements for RUNDC3B Gene

Enhancers for RUNDC3B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F087598 1.3 Ensembl ENCODE 12 -27.7 -27650 3.2 HDGF PKNOX1 MLX ZFP64 ARID4B YBX1 FEZF1 DMAP1 ZNF48 ZNF2 RUNDC3B SLC25A40 GC07P087616 GC07P087522
GH07F087574 1.2 FANTOM5 ENCODE 11.1 -52.8 -52779 0.2 ATF1 INSM2 KLF17 ZEB1 CBX5 ZNF366 SCRT2 FOS CREM ZNF362 RUNDC3B GC07P087616 GC07P087522
GH07F087873 1.1 ENCODE 10.7 +249.3 249341 6.4 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF143 ZNF207 TMEM243 RUNDC3B SLC25A40 ABCB4 ADAM22
GH07F087589 1 ENCODE 11.3 -36.2 -36233 2.9 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 ZNF143 RUNDC3B ABCB1 GC07P087616 GC07P087522
GH07F087564 0.7 ENCODE 11.5 -63.0 -63011 1.1 SOX13 GATAD2A CTCF ZNF146 SAP130 FOXA3 ZNF644 RAD21 ATF3 POLR2A RUNDC3B GC07P087522 GC07P087616
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RUNDC3B on UCSC Golden Path with GeneCards custom track

Promoters for RUNDC3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001893809 953 2199 PKNOX1 ARID4B SIN3A FEZF1 GLIS2 ZNF143 ZNF263 SP3 SP5 NFYC

Genomic Location for RUNDC3B Gene

Chromosome:
7
Start:
87,627,548 bp from pter
End:
87,832,298 bp from pter
Size:
204,751 bases
Orientation:
Plus strand

Genomic View for RUNDC3B Gene

Genes around RUNDC3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RUNDC3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RUNDC3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RUNDC3B Gene

Proteins for RUNDC3B Gene

  • Protein details for RUNDC3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NL0-RUN3B_HUMAN
    Recommended name:
    RUN domain-containing protein 3B
    Protein Accession:
    Q96NL0
    Secondary Accessions:
    • B4DFD0
    • E9PBR4
    • Q8IWW5
    • Q8NB55
    • Q8TBG7

    Protein attributes for RUNDC3B Gene

    Size:
    473 amino acids
    Molecular mass:
    52813 Da
    Quaternary structure:
    • Interacts with RAP2A.
    SequenceCaution:
    • Sequence=AAH22520.1; Type=Frameshift; Positions=444; Evidence={ECO:0000305};

    Alternative splice isoforms for RUNDC3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RUNDC3B Gene

Post-translational modifications for RUNDC3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RUNDC3B Gene

Domains & Families for RUNDC3B Gene

Protein Domains for RUNDC3B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RUNDC3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96NL0

UniProtKB/Swiss-Prot:

RUN3B_HUMAN :
  • Contains 1 RUN domain.
  • Belongs to the RUNDC3 family.
Domain:
  • Contains 1 RUN domain.
Family:
  • Belongs to the RUNDC3 family.
genes like me logo Genes that share domains with RUNDC3B: view

No data available for Gene Families for RUNDC3B Gene

Function for RUNDC3B Gene

genes like me logo Genes that share phenotypes with RUNDC3B: view

Animal Model Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RUNDC3B Gene

Localization for RUNDC3B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RUNDC3B gene
Compartment Confidence
mitochondrion 2
nucleus 1
endoplasmic reticulum 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RUNDC3B Gene

Pathways & Interactions for RUNDC3B Gene

SuperPathways for RUNDC3B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RUNDC3B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RUNDC3B Gene

Transcripts for RUNDC3B Gene

Unigene Clusters for RUNDC3B Gene

RUN domain containing 3B:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RUNDC3B Gene

No ASD Table

Relevant External Links for RUNDC3B Gene

GeneLoc Exon Structure for
RUNDC3B
ECgene alternative splicing isoforms for
RUNDC3B

Expression for RUNDC3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RUNDC3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RUNDC3B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.4).

Protein differential expression in normal tissues from HIPED for RUNDC3B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (53.9) and Heart (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RUNDC3B Gene



Protein tissue co-expression partners for RUNDC3B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RUNDC3B Gene:

RUNDC3B

SOURCE GeneReport for Unigene cluster for RUNDC3B Gene:

Hs.411488

mRNA Expression by UniProt/SwissProt for RUNDC3B Gene:

Q96NL0-RUN3B_HUMAN
Tissue specificity: Isoform 2 is expressed at high levels in brain, thymus, ovary, testis, leukocyte, liver, small intestine and prostate. Isoform 1 is expressed in the brain, testis and adrenal gland. It is activated in tumorigenic breast cancer cell lines and in the primary tumor of breast cancer patients. Activation also correlates with metastatic lymph node invasion and can be detected in metastatic epithelial cells from the lymph nodes and in the bone marrow of patients.
genes like me logo Genes that share expression patterns with RUNDC3B: view

Primer Products

Orthologs for RUNDC3B Gene

This gene was present in the common ancestor of animals.

Orthologs for RUNDC3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RUNDC3B 34 35
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia RUNDC3B 34 35
  • 94.68 (n)
cow
(Bos Taurus)
Mammalia RUNDC3B 34 35
  • 92.74 (n)
mouse
(Mus musculus)
Mammalia Rundc3b 34 16 35
  • 88.83 (n)
rat
(Rattus norvegicus)
Mammalia Rundc3b 34
  • 88.22 (n)
oppossum
(Monodelphis domestica)
Mammalia RUNDC3B 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RUNDC3B 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves RUNDC3B 34 35
  • 83.11 (n)
lizard
(Anolis carolinensis)
Reptilia RUNDC3B 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76082 34
zebrafish
(Danio rerio)
Actinopterygii rundc3b 35
  • 76 (a)
OneToOne
Dr.28461 34
fruit fly
(Drosophila melanogaster)
Insecta CG31064 35
  • 10 (a)
OneToMany
Species where no ortholog for RUNDC3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RUNDC3B Gene

ENSEMBL:
Gene Tree for RUNDC3B (if available)
TreeFam:
Gene Tree for RUNDC3B (if available)

Paralogs for RUNDC3B Gene

Paralogs for RUNDC3B Gene

(1) SIMAP similar genes for RUNDC3B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RUNDC3B: view

Variants for RUNDC3B Gene

Sequence variations from dbSNP and Humsavar for RUNDC3B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1015415 -- 87,700,785(-) acatt(A/T)tgtac intron-variant
rs10224594 -- 87,644,123(+) CAAAG(C/T)GTTGG intron-variant
rs10225368 -- 87,765,890(+) agtag(A/G)gtgtt intron-variant
rs10226830 -- 87,753,620(+) ttacc(A/G)ttatg intron-variant
rs10226849 -- 87,783,764(+) agctt(A/G)gtttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RUNDC3B Gene

Variant ID Type Subtype PubMed ID
dgv11489n54 CNV loss 21841781
esv2666273 CNV deletion 23128226
esv2734776 CNV deletion 23290073
esv28195 CNV loss 19812545
esv3542043 CNV deletion 23714750
esv3571956 CNV loss 25503493
esv3614037 CNV loss 21293372
esv7655 CNV loss 19470904
nsv464622 CNV gain 19166990
nsv607728 CNV loss 21841781
nsv607725 CNV gain 21841781
nsv528078 CNV loss 19592680
nsv477542 CNV novel sequence insertion 20440878

Variation tolerance for RUNDC3B Gene

Residual Variation Intolerance Score: 19.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RUNDC3B Gene

Human Gene Mutation Database (HGMD)
RUNDC3B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RUNDC3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RUNDC3B Gene

Disorders for RUNDC3B Gene

Relevant External Links for RUNDC3B

Genetic Association Database (GAD)
RUNDC3B
Human Genome Epidemiology (HuGE) Navigator
RUNDC3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RUNDC3B

No disorders were found for RUNDC3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RUNDC3B Gene

Publications for RUNDC3B Gene

  1. Cloning, expression, and genomic structure of a novel human Rap2 interacting gene (RPIP9). (PMID: 12645870) Wang S. … Mao Y.-M. (Biochem. Genet. 2003) 2 3 4 22 64
  2. Expression of RPIP9 (Rap2 interacting protein 9) is activated in breast carcinoma and correlates with a poor prognosis. (PMID: 15986426) Raguz S. … Yague E. (Int. J. Cancer 2005) 3 4 22 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64

Products for RUNDC3B Gene

Sources for RUNDC3B Gene

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