Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RUNDC3B Gene

Aliases for RUNDC3B Gene

  • RUN Domain Containing 3B 2 3 5
  • Rap2-Interacting Protein 9 3 4
  • Rap2-Binding Protein 9 3 4
  • RPIP-9 3 4
  • RPIB9 3 4
  • RPIP9 3 4
  • Rap2 Binding Protein 9 3

External Ids for RUNDC3B Gene

Previous GeneCards Identifiers for RUNDC3B Gene

  • GC07P087096
  • GC07P087256
  • GC07P081867

Summaries for RUNDC3B Gene

GeneCards Summary for RUNDC3B Gene

RUNDC3B (RUN Domain Containing 3B) is a Protein Coding gene. An important paralog of this gene is RUFY2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RUNDC3B Gene

Genomics for RUNDC3B Gene

Regulatory Elements for RUNDC3B Gene

Enhancers for RUNDC3B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RUNDC3B on UCSC Golden Path with GeneCards custom track

Promoters for RUNDC3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RUNDC3B on UCSC Golden Path with GeneCards custom track

Genomic Location for RUNDC3B Gene

87,627,548 bp from pter
87,832,298 bp from pter
204,751 bases
Plus strand

Genomic View for RUNDC3B Gene

Genes around RUNDC3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RUNDC3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RUNDC3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RUNDC3B Gene

Proteins for RUNDC3B Gene

  • Protein details for RUNDC3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RUN domain-containing protein 3B
    Protein Accession:
    Secondary Accessions:
    • B4DFD0
    • E9PBR4
    • Q8IWW5
    • Q8NB55
    • Q8TBG7

    Protein attributes for RUNDC3B Gene

    473 amino acids
    Molecular mass:
    52813 Da
    Quaternary structure:
    • Interacts with RAP2A.
    • Sequence=AAH22520.1; Type=Frameshift; Positions=444; Evidence={ECO:0000305};

    Alternative splice isoforms for RUNDC3B Gene


neXtProt entry for RUNDC3B Gene

Proteomics data for RUNDC3B Gene at MOPED

Post-translational modifications for RUNDC3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RUNDC3B Gene

No data available for DME Specific Peptides for RUNDC3B Gene

Domains & Families for RUNDC3B Gene

Protein Domains for RUNDC3B Gene


Suggested Antigen Peptide Sequences for RUNDC3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RUN domain.
  • Belongs to the RUNDC3 family.
  • Contains 1 RUN domain.
  • Belongs to the RUNDC3 family.
genes like me logo Genes that share domains with RUNDC3B: view

No data available for Gene Families for RUNDC3B Gene

Function for RUNDC3B Gene

genes like me logo Genes that share phenotypes with RUNDC3B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RUNDC3B Gene

Localization for RUNDC3B Gene

Subcellular locations from

Jensen Localization Image for RUNDC3B Gene COMPARTMENTS Subcellular localization image for RUNDC3B gene
Compartment Confidence
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RUNDC3B Gene

Pathways & Interactions for RUNDC3B Gene

SuperPathways for RUNDC3B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RUNDC3B Gene


No data available for Pathways by source and SIGNOR curated interactions for RUNDC3B Gene

Drugs & Compounds for RUNDC3B Gene

No Compound Related Data Available

Transcripts for RUNDC3B Gene

Unigene Clusters for RUNDC3B Gene

RUN domain containing 3B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RUNDC3B Gene

No ASD Table

Relevant External Links for RUNDC3B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RUNDC3B Gene

mRNA expression in normal human tissues for RUNDC3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RUNDC3B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.4).

Protein differential expression in normal tissues from HIPED for RUNDC3B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (53.9) and Heart (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RUNDC3B Gene

SOURCE GeneReport for Unigene cluster for RUNDC3B Gene Hs.411488

mRNA Expression by UniProt/SwissProt for RUNDC3B Gene

Tissue specificity: Isoform 2 is expressed at high levels in brain, thymus, ovary, testis, leukocyte, liver, small intestine and prostate. Isoform 1 is expressed in the brain, testis and adrenal gland. It is activated in tumorigenic breast cancer cell lines and in the primary tumor of breast cancer patients. Activation also correlates with metastatic lymph node invasion and can be detected in metastatic epithelial cells from the lymph nodes and in the bone marrow of patients.
genes like me logo Genes that share expression patterns with RUNDC3B: view

Protein tissue co-expression partners for RUNDC3B Gene

- Elite partner

Primer Products

Orthologs for RUNDC3B Gene

This gene was present in the common ancestor of animals.

Orthologs for RUNDC3B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RUNDC3B 35
  • 92.74 (n)
  • 95.05 (a)
  • 95 (a)
(Canis familiaris)
Mammalia RUNDC3B 35
  • 94.68 (n)
  • 98.38 (a)
  • 98 (a)
(Mus musculus)
Mammalia Rundc3b 35
  • 88.83 (n)
  • 94.76 (a)
Rundc3b 16
Rundc3b 36
  • 95 (a)
(Pan troglodytes)
Mammalia RUNDC3B 35
  • 99.79 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Rundc3b 35
  • 88.22 (n)
  • 94.76 (a)
(Monodelphis domestica)
Mammalia RUNDC3B 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia RUNDC3B 36
  • 84 (a)
(Gallus gallus)
Aves RUNDC3B 35
  • 83.11 (n)
  • 91.5 (a)
  • 91 (a)
(Anolis carolinensis)
Reptilia RUNDC3B 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76082 35
(Danio rerio)
Actinopterygii Dr.28461 35
rundc3b 36
  • 76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31064 36
  • 10 (a)
Species with no ortholog for RUNDC3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RUNDC3B Gene

Gene Tree for RUNDC3B (if available)
Gene Tree for RUNDC3B (if available)

Paralogs for RUNDC3B Gene

Paralogs for RUNDC3B Gene

(1) SIMAP similar genes for RUNDC3B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RUNDC3B: view

Variants for RUNDC3B Gene

Sequence variations from dbSNP and Humsavar for RUNDC3B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_043473 -
rs17852063 - 87,741,516(+) GGGAG(A/G)GGGGC reference, missense
rs17856673 - 87,829,927(+) ATCTC(C/T)AACGT reference, missense
rs961151 -- 87,779,030(+) cacat(A/G)cattt intron-variant
rs976602 -- 87,723,632(-) AATTC(A/G)GTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RUNDC3B Gene

Variant ID Type Subtype PubMed ID
nsv888677 CNV Gain 21882294
nsv464622 CNV Gain 19166990
nsv888692 CNV Loss 21882294
esv2734776 CNV Deletion 23290073
esv7655 CNV Loss 19470904
esv2666273 CNV Deletion 23128226
esv28195 CNV Loss 19812545
dgv7384n71 CNV Loss 21882294
nsv888695 CNV Loss 21882294
nsv528078 CNV Loss 19592680

Variation tolerance for RUNDC3B Gene

Residual Variation Intolerance Score: 19.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RUNDC3B Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RUNDC3B Gene

Disorders for RUNDC3B Gene

Relevant External Links for RUNDC3B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RUNDC3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RUNDC3B Gene

Publications for RUNDC3B Gene

  1. Cloning, expression, and genomic structure of a novel human Rap2 interacting gene (RPIP9). (PMID: 12645870) Wang S. … Mao Y.-M. (Biochem. Genet. 2003) 2 3 4 23 67
  2. Expression of RPIP9 (Rap2 interacting protein 9) is activated in breast carcinoma and correlates with a poor prognosis. (PMID: 15986426) Raguz S. … Yague E. (Int. J. Cancer 2005) 3 23
  3. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 3
  4. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 3
  5. Dual regulation of P-glycoprotein expression by trichostatin A in cancer cell lines. (PMID: 22846052) Balaguer T.M. … Saceda M. (BMC Mol. Biol. 2012) 3

Products for RUNDC3B Gene

Sources for RUNDC3B Gene