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Aliases for RUNDC3A Gene

Aliases for RUNDC3A Gene

  • RUN Domain Containing 3A 2 3 5
  • Rap2-Interacting Protein 8 3 4
  • RAP2IP 3 4
  • RPIP-8 3 4
  • RPIP8 3 4
  • RaP2 Interacting Protein 8 3

External Ids for RUNDC3A Gene

Previous GeneCards Identifiers for RUNDC3A Gene

  • GC17P039743
  • GC17P042385
  • GC17P038149

Summaries for RUNDC3A Gene

GeneCards Summary for RUNDC3A Gene

RUNDC3A (RUN Domain Containing 3A) is a Protein Coding gene. GO annotations related to this gene include GTPase regulator activity and guanylate cyclase activator activity. An important paralog of this gene is RUFY2.

UniProtKB/Swiss-Prot for RUNDC3A Gene

  • May act as an effector of RAP2A in neuronal cells.

Gene Wiki entry for RUNDC3A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RUNDC3A Gene

Genomics for RUNDC3A Gene

Regulatory Elements for RUNDC3A Gene

Promoters for RUNDC3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RUNDC3A on UCSC Golden Path with GeneCards custom track

Genomic Location for RUNDC3A Gene

Chromosome:
17
Start:
44,307,918 bp from pter
End:
44,318,671 bp from pter
Size:
10,754 bases
Orientation:
Plus strand

Genomic View for RUNDC3A Gene

Genes around RUNDC3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RUNDC3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RUNDC3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RUNDC3A Gene

Proteins for RUNDC3A Gene

  • Protein details for RUNDC3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q59EK9-RUN3A_HUMAN
    Recommended name:
    RUN domain-containing protein 3A
    Protein Accession:
    Q59EK9
    Secondary Accessions:
    • B2R974
    • O15483
    • O60651
    • Q7Z3S2
    • Q9UF50

    Protein attributes for RUNDC3A Gene

    Size:
    446 amino acids
    Molecular mass:
    49747 Da
    Quaternary structure:
    • Interacts with the GTP-bound form of RAP2A.
    SequenceCaution:
    • Sequence=BAD93039.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RUNDC3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RUNDC3A Gene

Proteomics data for RUNDC3A Gene at MOPED

Post-translational modifications for RUNDC3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RUNDC3A Gene

No data available for DME Specific Peptides for RUNDC3A Gene

Domains & Families for RUNDC3A Gene

Protein Domains for RUNDC3A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RUNDC3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q59EK9

UniProtKB/Swiss-Prot:

RUN3A_HUMAN :
  • Contains 1 RUN domain.
  • Belongs to the RUNDC3 family.
Domain:
  • Contains 1 RUN domain.
Family:
  • Belongs to the RUNDC3 family.
genes like me logo Genes that share domains with RUNDC3A: view

No data available for Gene Families for RUNDC3A Gene

Function for RUNDC3A Gene

Molecular function for RUNDC3A Gene

UniProtKB/Swiss-Prot Function:
May act as an effector of RAP2A in neuronal cells.

Gene Ontology (GO) - Molecular Function for RUNDC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030695 GTPase regulator activity TAS 9523700
GO:0051428 peptide hormone receptor binding IEA --
genes like me logo Genes that share ontologies with RUNDC3A: view
genes like me logo Genes that share phenotypes with RUNDC3A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RUNDC3A Gene

Localization for RUNDC3A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RUNDC3A Gene COMPARTMENTS Subcellular localization image for RUNDC3A gene
Compartment Confidence
cytosol 3
mitochondrion 2
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RUNDC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with RUNDC3A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RUNDC3A Gene

Pathways & Interactions for RUNDC3A Gene

SuperPathways for RUNDC3A Gene

No Data Available

Gene Ontology (GO) - Biological Process for RUNDC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031284 positive regulation of guanylate cyclase activity IEA --
genes like me logo Genes that share ontologies with RUNDC3A: view

No data available for Pathways by source and SIGNOR curated interactions for RUNDC3A Gene

Drugs & Compounds for RUNDC3A Gene

(1) Drugs for RUNDC3A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RUNDC3A: view

Transcripts for RUNDC3A Gene

Unigene Clusters for RUNDC3A Gene

RUN domain containing 3A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RUNDC3A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6: - -
SP7: -

Relevant External Links for RUNDC3A Gene

GeneLoc Exon Structure for
RUNDC3A
ECgene alternative splicing isoforms for
RUNDC3A

Expression for RUNDC3A Gene

mRNA expression in normal human tissues for RUNDC3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RUNDC3A Gene

This gene is overexpressed in Brain - Cortex (x6.1), Brain - Frontal Cortex (BA9) (x5.2), Brain - Anterior cingulate cortex (BA24) (x5.2), Brain - Hippocampus (x4.5), and Brain - Amygdala (x4.4).

Protein differential expression in normal tissues from HIPED for RUNDC3A Gene

This gene is overexpressed in Frontal cortex (32.3), Fetal Brain (17.7), and Retina (15.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RUNDC3A Gene



SOURCE GeneReport for Unigene cluster for RUNDC3A Gene Hs.500197

genes like me logo Genes that share expression patterns with RUNDC3A: view

Protein tissue co-expression partners for RUNDC3A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RUNDC3A Gene

Orthologs for RUNDC3A Gene

This gene was present in the common ancestor of animals.

Orthologs for RUNDC3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RUNDC3A 35
  • 97.41 (n)
  • 97.33 (a)
RUNDC3A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RUNDC3A 35
  • 93.65 (n)
  • 97.28 (a)
RUNDC3A 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RUNDC3A 36
  • 98 (a)
OneToOne
RUNDC3A 35
  • 94.77 (n)
  • 97.76 (a)
mouse
(Mus musculus)
Mammalia Rundc3a 16
Rundc3a 36
  • 96 (a)
OneToOne
Rundc3a 35
  • 90.96 (n)
  • 96.41 (a)
oppossum
(Monodelphis domestica)
Mammalia RUNDC3A 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RUNDC3A 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rundc3a 35
  • 90.81 (n)
  • 96.64 (a)
chicken
(Gallus gallus)
Aves RUNDC3A 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RUNDC3A 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15517 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rundc3a 35
  • 74.02 (n)
  • 80 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6033 35
zebrafish
(Danio rerio)
Actinopterygii rundc3ab 35
  • 69.24 (n)
  • 73.13 (a)
zgc55922 35
RUNDC3A (2 of 2) 36
  • 72 (a)
OneToMany
rundc3ab 36
  • 73 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG31064 36
  • 11 (a)
OneToMany
Species with no ortholog for RUNDC3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RUNDC3A Gene

ENSEMBL:
Gene Tree for RUNDC3A (if available)
TreeFam:
Gene Tree for RUNDC3A (if available)

Paralogs for RUNDC3A Gene

Paralogs for RUNDC3A Gene

(2) SIMAP similar genes for RUNDC3A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RUNDC3A: view

Variants for RUNDC3A Gene

Sequence variations from dbSNP and Humsavar for RUNDC3A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1985344 -- 44,313,742(-) atcgc(A/G)ccatc intron-variant
rs1043644 -- 44,317,702(+) TAGCC(C/G)CATCA intron-variant, utr-variant-3-prime
rs3785818 -- 44,311,910(-) AGGTG(C/G)GGGGT intron-variant
rs9902629 -- 44,318,200(+) TGAGC(A/G)ACAGT downstream-variant-500B, reference, missense
rs11654436 -- 44,316,094(+) CTTAC(A/C)CTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RUNDC3A Gene

Variant ID Type Subtype PubMed ID
nsv908270 CNV Loss 21882294
nsv510713 CNV Loss 20534489
nsv908275 CNV Loss 21882294
dgv3175n71 CNV Loss 21882294
nsv908278 CNV Loss 21882294
nsv2061 CNV Insertion 18451855

Variation tolerance for RUNDC3A Gene

Gene Damage Index Score: 1.60; 30.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RUNDC3A Gene

HapMap Linkage Disequilibrium report
RUNDC3A
Human Gene Mutation Database (HGMD)
RUNDC3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RUNDC3A Gene

Disorders for RUNDC3A Gene

Relevant External Links for RUNDC3A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RUNDC3A

No disorders were found for RUNDC3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RUNDC3A Gene

Publications for RUNDC3A Gene

  1. Identification of a specific effector of the small GTP-binding protein Rap2. (PMID: 9523700) Janoueix-Lerosey I. … de Gunzburg J. (Eur. J. Biochem. 1998) 2 3 4 23 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for RUNDC3A Gene

Sources for RUNDC3A Gene

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