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Aliases for RUNDC3A Gene

Aliases for RUNDC3A Gene

  • RUN Domain Containing 3A 2 3 5
  • Rap2-Interacting Protein 8 3 4
  • RAP2IP 3 4
  • RPIP-8 3 4
  • RPIP8 3 4
  • RUN Domain-Containing Protein 3A 3
  • RaP2 Interacting Protein 8 3

External Ids for RUNDC3A Gene

Previous GeneCards Identifiers for RUNDC3A Gene

  • GC17P039743
  • GC17P042385
  • GC17P038149

Summaries for RUNDC3A Gene

GeneCards Summary for RUNDC3A Gene

RUNDC3A (RUN Domain Containing 3A) is a Protein Coding gene. GO annotations related to this gene include GTPase regulator activity and guanylate cyclase activator activity. An important paralog of this gene is RUNDC3B.

UniProtKB/Swiss-Prot for RUNDC3A Gene

  • May act as an effector of RAP2A in neuronal cells.

Gene Wiki entry for RUNDC3A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RUNDC3A Gene

Genomics for RUNDC3A Gene

Regulatory Elements for RUNDC3A Gene

Enhancers for RUNDC3A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G044344 1.8 FANTOM5 ENCODE dbSUPER 11.4 +39.2 39240 5.5 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF416 ZNF263 DHX8 SLC25A39 MEOX1 EFTUD2 RUNDC3A-AS1 ASB16-AS1 UBTF RUNDC3A ENSG00000221496 RNU6-453P
GH17G044268 1.1 FANTOM5 ENCODE 1.7 -38.0 -38015 2.8 SIN3A ZNF384 FOSL1 GATA3 GLIS2 ZNF766 ZNF316 GATA2 POLR2A FOS SLC4A1 GRN SLC25A39 UBTF RUNDC3A LOC105371790
GH17G044281 1.1 FANTOM5 dbSUPER 1.6 -26.1 -26134 0.3 HDGF PKNOX1 ESRRA TAL1 TCF12 GATA2 NCOR1 RNF2 MTA2 DPF2 SLC4A1 SLC25A39 UBTF RUNDC3A LOC105371790 RN7SL507P GC17M044291
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RUNDC3A on UCSC Golden Path with GeneCards custom track

Promoters for RUNDC3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000094746 682 801 HDGF ATF1 ZFP64 ARID4B SIN3A ZNF48 ZBTB7B SLC30A9 ZNF766 GLIS2

Genomic Location for RUNDC3A Gene

44,307,918 bp from pter
44,318,671 bp from pter
10,754 bases
Plus strand

Genomic View for RUNDC3A Gene

Genes around RUNDC3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RUNDC3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RUNDC3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RUNDC3A Gene

Proteins for RUNDC3A Gene

  • Protein details for RUNDC3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RUN domain-containing protein 3A
    Protein Accession:
    Secondary Accessions:
    • B2R974
    • O15483
    • O60651
    • Q7Z3S2
    • Q9UF50

    Protein attributes for RUNDC3A Gene

    446 amino acids
    Molecular mass:
    49747 Da
    Quaternary structure:
    • Interacts with the GTP-bound form of RAP2A.
    • Sequence=BAD93039.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RUNDC3A Gene


neXtProt entry for RUNDC3A Gene

Post-translational modifications for RUNDC3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RUNDC3A Gene

Domains & Families for RUNDC3A Gene

Protein Domains for RUNDC3A Gene


Suggested Antigen Peptide Sequences for RUNDC3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RUNDC3 family.
  • Belongs to the RUNDC3 family.
genes like me logo Genes that share domains with RUNDC3A: view

No data available for Gene Families for RUNDC3A Gene

Function for RUNDC3A Gene

Molecular function for RUNDC3A Gene

UniProtKB/Swiss-Prot Function:
May act as an effector of RAP2A in neuronal cells.

Gene Ontology (GO) - Molecular Function for RUNDC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0030250 guanylate cyclase activator activity IEA --
GO:0030695 GTPase regulator activity TAS 9523700
GO:0051428 peptide hormone receptor binding IEA --
genes like me logo Genes that share ontologies with RUNDC3A: view
genes like me logo Genes that share phenotypes with RUNDC3A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RUNDC3A Gene

Localization for RUNDC3A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RUNDC3A gene
Compartment Confidence
cytosol 3
plasma membrane 2
mitochondrion 2
cytoskeleton 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RUNDC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with RUNDC3A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RUNDC3A Gene

Pathways & Interactions for RUNDC3A Gene

SuperPathways for RUNDC3A Gene

No Data Available

Gene Ontology (GO) - Biological Process for RUNDC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS 9523700
GO:0030828 positive regulation of cGMP biosynthetic process IEA --
GO:0031284 positive regulation of guanylate cyclase activity IEA --
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with RUNDC3A: view

No data available for Pathways by source and SIGNOR curated interactions for RUNDC3A Gene

Drugs & Compounds for RUNDC3A Gene

(1) Drugs for RUNDC3A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RUNDC3A: view

Transcripts for RUNDC3A Gene

Unigene Clusters for RUNDC3A Gene

RUN domain containing 3A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RUNDC3A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: -
SP2: -
SP3: -
SP4: -
SP6: - -
SP7: -

Relevant External Links for RUNDC3A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RUNDC3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RUNDC3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RUNDC3A Gene

This gene is overexpressed in Brain - Cortex (x6.1), Brain - Frontal Cortex (BA9) (x5.2), Brain - Anterior cingulate cortex (BA24) (x5.2), Brain - Hippocampus (x4.5), and Brain - Amygdala (x4.4).

Protein differential expression in normal tissues from HIPED for RUNDC3A Gene

This gene is overexpressed in Frontal cortex (32.3), Fetal Brain (17.7), and Retina (15.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RUNDC3A Gene

Protein tissue co-expression partners for RUNDC3A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RUNDC3A Gene:


SOURCE GeneReport for Unigene cluster for RUNDC3A Gene:


Evidence on tissue expression from TISSUES for RUNDC3A Gene

  • Nervous system(4.9)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with RUNDC3A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RUNDC3A Gene

Orthologs for RUNDC3A Gene

This gene was present in the common ancestor of animals.

Orthologs for RUNDC3A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RUNDC3A 34 35
  • 97.41 (n)
(Canis familiaris)
Mammalia RUNDC3A 34 35
  • 94.77 (n)
(Bos Taurus)
Mammalia RUNDC3A 34 35
  • 93.65 (n)
(Mus musculus)
Mammalia Rundc3a 34 16 35
  • 90.96 (n)
(Rattus norvegicus)
Mammalia Rundc3a 34
  • 90.81 (n)
(Monodelphis domestica)
Mammalia RUNDC3A 35
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia RUNDC3A 35
  • 73 (a)
(Gallus gallus)
Aves RUNDC3A 35
  • 83 (a)
(Anolis carolinensis)
Reptilia RUNDC3A 35
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rundc3a 34
  • 74.02 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15517 34
(Danio rerio)
Actinopterygii RUNDC3A (2 of 2) 35
  • 72 (a)
rundc3ab 34 35
  • 69.24 (n)
zgc55922 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6033 34
fruit fly
(Drosophila melanogaster)
Insecta CG31064 35
  • 11 (a)
Species where no ortholog for RUNDC3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RUNDC3A Gene

Gene Tree for RUNDC3A (if available)
Gene Tree for RUNDC3A (if available)

Paralogs for RUNDC3A Gene

Paralogs for RUNDC3A Gene

(2) SIMAP similar genes for RUNDC3A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RUNDC3A: view

Variants for RUNDC3A Gene

Sequence variations from dbSNP and Humsavar for RUNDC3A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000305802 -- 44,311,959(+) CTGGG(C/T)AGCTG intron-variant
rs1000564459 -- 44,316,969(+) AAGCG(C/G)CTGCC intron-variant
rs1000737370 -- 44,317,394(+) ACTCT(A/C/G)GGGGA intron-variant
rs1000755048 -- 44,310,583(+) CTGCC(G/T)CATCA intron-variant
rs1000808975 -- 44,310,620(+) CAGAA(A/C)AGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RUNDC3A Gene

Variant ID Type Subtype PubMed ID
nsv1127576 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv2061 CNV insertion 18451855
nsv510713 CNV deletion 20534489

Variation tolerance for RUNDC3A Gene

Gene Damage Index Score: 1.60; 30.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RUNDC3A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RUNDC3A Gene

Disorders for RUNDC3A Gene

Relevant External Links for RUNDC3A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RUNDC3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RUNDC3A Gene

Publications for RUNDC3A Gene

  1. Identification of a specific effector of the small GTP-binding protein Rap2. (PMID: 9523700) Janoueix-Lerosey I. … de Gunzburg J. (Eur. J. Biochem. 1998) 2 3 4 22 64
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3 64
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for RUNDC3A Gene

Sources for RUNDC3A Gene

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