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Aliases for RUNDC1 Gene

Aliases for RUNDC1 Gene

  • RUN Domain Containing 1 2 3 5

External Ids for RUNDC1 Gene

Previous GeneCards Identifiers for RUNDC1 Gene

  • GC17P041506
  • GC17P038386
  • GC17P041132
  • GC17P036898
  • GC17P042981
  • GC17P043060

Summaries for RUNDC1 Gene

GeneCards Summary for RUNDC1 Gene

RUNDC1 (RUN Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for RUNDC1 Gene

  • May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RUNDC1 Gene

Genomics for RUNDC1 Gene

Regulatory Elements for RUNDC1 Gene

Promoters for RUNDC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RUNDC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RUNDC1 Gene

Chromosome:
17
Start:
42,980,510 bp from pter
End:
42,993,696 bp from pter
Size:
13,187 bases
Orientation:
Plus strand

Genomic View for RUNDC1 Gene

Genes around RUNDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RUNDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RUNDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RUNDC1 Gene

Proteins for RUNDC1 Gene

  • Protein details for RUNDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C34-RUND1_HUMAN
    Recommended name:
    RUN domain-containing protein 1
    Protein Accession:
    Q96C34
    Secondary Accessions:
    • Q6Y2K8
    • Q8IXT9
    • Q8N3W1

    Protein attributes for RUNDC1 Gene

    Size:
    613 amino acids
    Molecular mass:
    67643 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH14873.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAO86728.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RUNDC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RUNDC1 Gene

Proteomics data for RUNDC1 Gene at MOPED

Post-translational modifications for RUNDC1 Gene

  • Ubiquitination at Lys 383
  • Modification sites at PhosphoSitePlus

Other Protein References for RUNDC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RUNDC1 Gene

Domains & Families for RUNDC1 Gene

Protein Domains for RUNDC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RUNDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96C34

UniProtKB/Swiss-Prot:

RUND1_HUMAN :
  • Contains 1 RUN domain.
Domain:
  • Contains 1 RUN domain.
genes like me logo Genes that share domains with RUNDC1: view

No data available for Gene Families for RUNDC1 Gene

Function for RUNDC1 Gene

Molecular function for RUNDC1 Gene

UniProtKB/Swiss-Prot Function:
May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.

Gene Ontology (GO) - Molecular Function for RUNDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017137 Rab GTPase binding IBA --
genes like me logo Genes that share ontologies with RUNDC1: view
genes like me logo Genes that share phenotypes with RUNDC1: view

Animal Models for RUNDC1 Gene

MGI Knock Outs for RUNDC1:

Animal Model Products

miRNA for RUNDC1 Gene

miRTarBase miRNAs that target RUNDC1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RUNDC1 Gene

Localization for RUNDC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RUNDC1 Gene COMPARTMENTS Subcellular localization image for RUNDC1 gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RUNDC1 Gene

Pathways & Interactions for RUNDC1 Gene

SuperPathways for RUNDC1 Gene

No Data Available

Interacting Proteins for RUNDC1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354622%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000354622 for RUNDC1 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for RUNDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090630 activation of GTPase activity IBA --
genes like me logo Genes that share ontologies with RUNDC1: view

No data available for Pathways by source and SIGNOR curated interactions for RUNDC1 Gene

Drugs & Compounds for RUNDC1 Gene

No Compound Related Data Available

Transcripts for RUNDC1 Gene

Unigene Clusters for RUNDC1 Gene

RUN domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RUNDC1 Gene

No ASD Table

Relevant External Links for RUNDC1 Gene

GeneLoc Exon Structure for
RUNDC1
ECgene alternative splicing isoforms for
RUNDC1

Expression for RUNDC1 Gene

mRNA expression in normal human tissues for RUNDC1 Gene

Protein differential expression in normal tissues from HIPED for RUNDC1 Gene

This gene is overexpressed in Monocytes (56.8) and Islet of Langerhans (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for RUNDC1 Gene



SOURCE GeneReport for Unigene cluster for RUNDC1 Gene Hs.632255

genes like me logo Genes that share expression patterns with RUNDC1: view

Protein tissue co-expression partners for RUNDC1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RUNDC1 Gene

Orthologs for RUNDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RUNDC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RUNDC1 35
  • 89.42 (n)
  • 93.02 (a)
RUNDC1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RUNDC1 35
  • 90.76 (n)
  • 94.62 (a)
RUNDC1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rundc1 35
  • 87.35 (n)
  • 90.35 (a)
Rundc1 16
Rundc1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RUNDC1 35
  • 99.73 (n)
  • 99.84 (a)
RUNDC1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rundc1 35
  • 86.86 (n)
  • 91.18 (a)
oppossum
(Monodelphis domestica)
Mammalia RUNDC1 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves RUNDC1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RUNDC1 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rundc1 35
  • 68.95 (n)
  • 68.47 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2440 35
zebrafish
(Danio rerio)
Actinopterygii LOC100537899 35
  • 67.28 (n)
  • 68.39 (a)
RUNDC1 36
  • 63 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12801 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004080 35
  • 47.9 (n)
  • 42.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3703 35
  • 48.97 (n)
  • 40.96 (a)
CG3703 36
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T19D7.4 36
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2174 36
  • 29 (a)
OneToOne
Species with no ortholog for RUNDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RUNDC1 Gene

ENSEMBL:
Gene Tree for RUNDC1 (if available)
TreeFam:
Gene Tree for RUNDC1 (if available)

Paralogs for RUNDC1 Gene

Pseudogenes.org Pseudogenes for RUNDC1 Gene

genes like me logo Genes that share paralogs with RUNDC1: view

No data available for Paralogs for RUNDC1 Gene

Variants for RUNDC1 Gene

Sequence variations from dbSNP and Humsavar for RUNDC1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_031760 -
VAR_031761 -
rs17857183 - 42,991,063(+) TAGCC(A/T)TGAGG reference, missense
rs3744241 - 42,991,570(+) TCATC(A/G)AGCCT reference, missense
rs189786 -- 42,992,475(-) tctcc(A/G/T)gcctc downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RUNDC1 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER Inversion 15654335
nsv483009 CNV Gain 15286789
nsv908258 CNV Loss 21882294
nsv457742 CNV Loss 19166990
esv2672913 CNV Deletion 23128226

Variation tolerance for RUNDC1 Gene

Residual Variation Intolerance Score: 81.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.58; 56.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RUNDC1 Gene

HapMap Linkage Disequilibrium report
RUNDC1
Human Gene Mutation Database (HGMD)
RUNDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RUNDC1 Gene

Disorders for RUNDC1 Gene

Relevant External Links for RUNDC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RUNDC1

No disorders were found for RUNDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RUNDC1 Gene

Publications for RUNDC1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for RUNDC1 Gene

Sources for RUNDC1 Gene

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