RUNDC1 Gene
protein-coding GIFtS: 37
GCID: GC17P041132
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RUN domain containing 1
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Aliases
for RUNDC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RUN Domain Containing 11 2 | | DKFZp761H04211 | | RUN Domain-Containing Protein 12 |
Export aliases for RUNDC1 gene to outside databasesPrevious GC identifers: GC17P041506 GC17P038386 GC17P036898 |
Summaries
for RUNDC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RUND1_HUMAN, Q96C34Function: May play a role as p53/TP53 inhibitor and thus may have oncogenic activity
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Genomic Views
for RUNDC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RUNDC1 gene promoter:
AML1a Ik-3 AP-2gamma C/EBPalpha FOXC1 AP-2beta AP-2alpha Zic3 AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for RUNDC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RUNDC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.31 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.31RUNDC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P041132: view genomic region
(about GC identifiers)
Start:
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41,132,582 bp from pter |
End:
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41,145,707 bp from pter |
Size:
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13,126 bases |
Orientation:
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plus strand |
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Proteins
for RUNDC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RUND1_HUMAN, Q96C34 (See
protein sequence)Recommended Name: RUN domain-containing protein 1 Size: 613 amino acids; 67643 Da
Sequence caution: Sequence=AAH14873.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=AAO86728.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6Y2K8 Q8IXT9 Q8N3W1Alternative splicing: 2 isoforms: Q96C34-1 Q96C34-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RUNDC1: NX_Q96C34
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96C34
RUNDC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775102.2
ENSEMBL proteins: ENSP00000354622 ENSP00000467953
Human Recombinant Protein Products for RUNDC1:
RUNDC1 Antibody Products:
Assay Products for RUNDC1: |
Protein
Domains /
Families
for RUNDC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RUNDC1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96C34ProtoNet protein and cluster: Q96C34 UniProtKB/Swiss-Prot: RUND1_HUMAN, Q96C34Similarity: Contains 1 RUN domain |
Function
for RUNDC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: RUND1_HUMAN, Q96C34Function: May play a role as p53/TP53 inhibitor and thus may have oncogenic activityPhenotypes:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Rundc1):
RUNDC1 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RUNDC1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RUNDC1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RUNDC1 (NM_173079) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RUNDC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUNDC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUNDC1 |
|
Pathways & Interactions
for RUNDC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RUNDC1
|
Drugs & Compounds
for RUNDC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RUNDC1
Search CenterWatch for drugs/clinical trials and news about RUNDC1 / RUND1
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Transcripts
for RUNDC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RUNDC1 gene: NM_173079.2 Unigene Cluster for RUNDC1: RUN domain containing 1 Hs.632255 [show with all ESTs]Unigene Representative Sequence: BC0392473 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000590836 ENST00000361677(uc002ici.1) ENST00000589705
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RUNDC1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RUNDC1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RUNDC1 (NM_173079) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RUNDC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUNDC1 |
Additional cDNA sequence: AK055627.1 AK303115.1 AK310125.1 AL831813.1 AY189284.1 BC014873.1 BC039247.1 1 DOTS entry: DT.311916 24/127 AceView cDNA sequences (see all 127): AA319233 BQ674809 BG253475 BG289440 AA234973 BU857624 BQ672941 BF063975 AK055627 BM692758 BU733793 AI341751 AY189284 AA844197 CA445450 BM838012 CA445266 BE768666 AI309843 AA688134 CB216808 BE768515 CA431990 BE262809
GeneLoc Exon Structure
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Expression
for RUNDC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RUNDC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTACTTATTT
About this image
See RUNDC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RUNDC1
SOURCE GeneReport for Unigene cluster: Hs.632255
SABiosciences Custom PCR Arrays for RUNDC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RUNDC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RUNDC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RUNDC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RUNDC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUNDC1 |
Orthologs
for RUNDC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RUNDC1 gene from 7/20 species (see all 20) About this table
ENSEMBL Gene Tree for RUNDC1 (if available)
TreeFam Gene Tree for RUNDC1 (if available) |
Paralogs
for RUNDC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RUNDC1 gene
RUNDC1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for RUNDC1
PGOHUM00000235813
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Genomic Variants
for RUNDC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RUNDC1 (41132582 - 41145707 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RUNDC1
1 CNV: 0206 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RUNDC1 |
|
Disorders
/ Diseases
for RUNDC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for RUNDC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RUNDC1 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with RUNDC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (2006)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- A high-throughput loss-of-function screening identifies novel p53 regulators. (PubMed id 16929179)2 Llanos S.... Serrano M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for RUNDC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing RUNDC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RUNDC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RUNDC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RUNDC1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for RUNDC1 gene:
Search GeneIP for patents involving RUNDC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RUNDC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RUNDC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RUNDC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RUNDC1 | | | OriGene Protein Over-expression Lysate for RUNDC1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for RUNDC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RUNDC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RUNDC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RUNDC1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RUNDC1 | | OriGene Custom Protein Services for RUNDC1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RUNDC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RUNDC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RUNDC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RUNDC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RUNDC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RUNDC1 |
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| | | | Search Tocris compounds for RUNDC1 |
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 | | | RUNDC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUNDC1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for RUNDC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUNDC1 |
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