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Aliases for RUNDC1 Gene

Aliases for RUNDC1 Gene

  • RUN Domain Containing 1 2 3 5

External Ids for RUNDC1 Gene

Previous GeneCards Identifiers for RUNDC1 Gene

  • GC17P041506
  • GC17P038386
  • GC17P041132
  • GC17P036898
  • GC17P042981
  • GC17P043060
  • GC17P043142
  • GC17P043146

Summaries for RUNDC1 Gene

GeneCards Summary for RUNDC1 Gene

RUNDC1 (RUN Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for RUNDC1 Gene

  • May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RUNDC1 Gene

Genomics for RUNDC1 Gene

Regulatory Elements for RUNDC1 Gene

Enhancers for RUNDC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F042953 0.5 ENCODE 12.6 -26.6 -26625 1.2 SCRT1 NFIA ZBTB48 FOXA3 SCRT2 SMAD4 NBR2 RPL27 PTGES3L-AARSD1 RUNDC1 AOC3 AOC2 CNTD1 COA3 IFI35 GC17P043177
GH17F043010 0.9 FANTOM5 ENCODE 11.8 +30.7 30726 2.2 PKNOX1 ATF1 MLX ARID4B FEZF1 DMAP1 ZNF48 GATA2 FOS SP5 NBR2 PTGES3L-AARSD1 RUNDC1 AARSD1 MLX CNTD1 RPL29P31 NBR1 ETV4 TUBG1
GH17F043014 1.1 ENCODE 11.8 +34.8 34798 2.6 PAF1 ZNF76 KLF17 MAX ZIC2 NR2F2 MIER3 GLIS2 POLR2A WT1 NBR2 PTGES3L-AARSD1 RUNDC1 AARSD1 IFI35 VAT1
GH17F042823 0.2 ENCODE 11.1 -156.4 -156433 1.7 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ZNF143 CNTD1 COA3 AOC2 AOC3 VPS25 RAMP2-AS1 RAMP2 HMGN2P15 WNK4 AARSD1
GH17F042586 0.8 Ensembl ENCODE 10.3 -393.3 -393251 2.0 L3MBTL2 ZEB2 CEBPG MNT POLR2A SCRT2 IKZF1 NBN HMBOX1 ZNF584 TUBG2 TUBG1 FAM134C AARSD1 PTGES3L-AARSD1 RUNDC1 CNTD1 COA3 PIR42459 ENSG00000280183
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RUNDC1 on UCSC Golden Path with GeneCards custom track

Promoters for RUNDC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001346738 90 2001 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207

Genomic Location for RUNDC1 Gene

Chromosome:
17
Start:
42,980,510 bp from pter
End:
42,993,696 bp from pter
Size:
13,187 bases
Orientation:
Plus strand

Genomic View for RUNDC1 Gene

Genes around RUNDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RUNDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RUNDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RUNDC1 Gene

Proteins for RUNDC1 Gene

  • Protein details for RUNDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C34-RUND1_HUMAN
    Recommended name:
    RUN domain-containing protein 1
    Protein Accession:
    Q96C34
    Secondary Accessions:
    • Q6Y2K8
    • Q8IXT9
    • Q8N3W1

    Protein attributes for RUNDC1 Gene

    Size:
    613 amino acids
    Molecular mass:
    67643 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH14873.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAO86728.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RUNDC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RUNDC1 Gene

Post-translational modifications for RUNDC1 Gene

  • Ubiquitination at Lys 383
  • Modification sites at PhosphoSitePlus

Other Protein References for RUNDC1 Gene

No data available for DME Specific Peptides for RUNDC1 Gene

Domains & Families for RUNDC1 Gene

Protein Domains for RUNDC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RUNDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96C34

UniProtKB/Swiss-Prot:

RUND1_HUMAN :
  • Contains 1 RUN domain.
Domain:
  • Contains 1 RUN domain.
genes like me logo Genes that share domains with RUNDC1: view

No data available for Gene Families for RUNDC1 Gene

Function for RUNDC1 Gene

Molecular function for RUNDC1 Gene

UniProtKB/Swiss-Prot Function:
May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.

Gene Ontology (GO) - Molecular Function for RUNDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0017137 Rab GTPase binding IBA --
genes like me logo Genes that share ontologies with RUNDC1: view
genes like me logo Genes that share phenotypes with RUNDC1: view

Animal Models for RUNDC1 Gene

MGI Knock Outs for RUNDC1:

Animal Model Products

miRNA for RUNDC1 Gene

miRTarBase miRNAs that target RUNDC1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RUNDC1 Gene

Localization for RUNDC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RUNDC1 Gene COMPARTMENTS Subcellular localization image for RUNDC1 gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RUNDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0012505 endomembrane system IBA --
genes like me logo Genes that share ontologies with RUNDC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RUNDC1 Gene

Pathways & Interactions for RUNDC1 Gene

SuperPathways for RUNDC1 Gene

No Data Available

Interacting Proteins for RUNDC1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354622%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000354622 Q96C34-RUND1_HUMAN for RUNDC1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for RUNDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0031338 regulation of vesicle fusion IBA --
GO:0090630 activation of GTPase activity IBA --
genes like me logo Genes that share ontologies with RUNDC1: view

No data available for Pathways by source and SIGNOR curated interactions for RUNDC1 Gene

Transcripts for RUNDC1 Gene

Unigene Clusters for RUNDC1 Gene

RUN domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RUNDC1 Gene

No ASD Table

Relevant External Links for RUNDC1 Gene

GeneLoc Exon Structure for
RUNDC1
ECgene alternative splicing isoforms for
RUNDC1

Expression for RUNDC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RUNDC1 Gene

Protein differential expression in normal tissues from HIPED for RUNDC1 Gene

This gene is overexpressed in Monocytes (56.8) and Islet of Langerhans (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RUNDC1 Gene



Protein tissue co-expression partners for RUNDC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RUNDC1 Gene:

RUNDC1

SOURCE GeneReport for Unigene cluster for RUNDC1 Gene:

Hs.632255
genes like me logo Genes that share expression patterns with RUNDC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RUNDC1 Gene

Orthologs for RUNDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RUNDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RUNDC1 34 35
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia RUNDC1 34 35
  • 90.76 (n)
cow
(Bos Taurus)
Mammalia RUNDC1 34 35
  • 89.42 (n)
mouse
(Mus musculus)
Mammalia Rundc1 34 16 35
  • 87.35 (n)
rat
(Rattus norvegicus)
Mammalia Rundc1 34
  • 86.86 (n)
oppossum
(Monodelphis domestica)
Mammalia RUNDC1 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves RUNDC1 35
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RUNDC1 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rundc1 34
  • 68.95 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2440 34
zebrafish
(Danio rerio)
Actinopterygii LOC100537899 34
  • 67.28 (n)
RUNDC1 35
  • 63 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12801 34
fruit fly
(Drosophila melanogaster)
Insecta CG3703 34 35
  • 48.97 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004080 34
  • 47.9 (n)
worm
(Caenorhabditis elegans)
Secernentea T19D7.4 35
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2174 35
  • 29 (a)
OneToOne
Species where no ortholog for RUNDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RUNDC1 Gene

ENSEMBL:
Gene Tree for RUNDC1 (if available)
TreeFam:
Gene Tree for RUNDC1 (if available)

Paralogs for RUNDC1 Gene

Pseudogenes.org Pseudogenes for RUNDC1 Gene

genes like me logo Genes that share paralogs with RUNDC1: view

No data available for Paralogs for RUNDC1 Gene

Variants for RUNDC1 Gene

Sequence variations from dbSNP and Humsavar for RUNDC1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs864622034 Uncertain significance 42,990,326(+) AGTGG(C/G)AAGCC reference, missense
rs1043281 -- 42,993,420(+) CTGCA(C/T)TATTA utr-variant-3-prime
rs1043284 -- 42,993,510(+) GTTCA(C/T)CTTCC utr-variant-3-prime
rs1055771 -- 42,985,682(+) AAATG(C/T)AATAC intron-variant
rs1055772 -- 42,985,845(+) GAAAT(A/G)CAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RUNDC1 Gene

Variant ID Type Subtype PubMed ID
esv2672913 CNV deletion 23128226
esv33998 OTHER inversion 15654335
nsv1146669 OTHER inversion 26484159
nsv457742 CNV loss 19166990
nsv483009 CNV gain 15286789
nsv575052 CNV loss 21841781

Variation tolerance for RUNDC1 Gene

Residual Variation Intolerance Score: 81.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.58; 56.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RUNDC1 Gene

Human Gene Mutation Database (HGMD)
RUNDC1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RUNDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RUNDC1 Gene

Disorders for RUNDC1 Gene

Relevant External Links for RUNDC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RUNDC1

No disorders were found for RUNDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RUNDC1 Gene

Publications for RUNDC1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 64
  4. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for RUNDC1 Gene

Sources for RUNDC1 Gene

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