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Aliases for RUFY4 Gene

Aliases for RUFY4 Gene

  • RUN And FYVE Domain Containing 4 2 3 5
  • ZFYVE31 3

External Ids for RUFY4 Gene

Previous GeneCards Identifiers for RUFY4 Gene

  • GC02P218607
  • GC02P218899
  • GC02P210753

Summaries for RUFY4 Gene

GeneCards Summary for RUFY4 Gene

RUFY4 (RUN And FYVE Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is FYCO1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RUFY4 Gene

Genomics for RUFY4 Gene

Regulatory Elements for RUFY4 Gene

Promoters for RUFY4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RUFY4 on UCSC Golden Path with GeneCards custom track

Genomic Location for RUFY4 Gene

Chromosome:
2
Start:
218,034,934 bp from pter
End:
218,090,625 bp from pter
Size:
55,692 bases
Orientation:
Plus strand

Genomic View for RUFY4 Gene

Genes around RUFY4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RUFY4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RUFY4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RUFY4 Gene

Proteins for RUFY4 Gene

  • Protein details for RUFY4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNE9-RUFY4_HUMAN
    Recommended name:
    RUN and FYVE domain-containing protein 4
    Protein Accession:
    Q6ZNE9
    Secondary Accessions:
    • Q6ZR96

    Protein attributes for RUFY4 Gene

    Size:
    571 amino acids
    Molecular mass:
    64350 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI13713.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC87417.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for RUFY4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RUFY4 Gene

Proteomics data for RUFY4 Gene at MOPED

Post-translational modifications for RUFY4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RUFY4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RUFY4 Gene

Domains & Families for RUFY4 Gene

Gene Families for RUFY4 Gene

Protein Domains for RUFY4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RUFY4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZNE9

UniProtKB/Swiss-Prot:

RUFY4_HUMAN :
  • Contains 1 RUN domain.
  • Contains 1 FYVE-type zinc finger.
Domain:
  • Contains 1 RUN domain.
Similarity:
  • Contains 1 FYVE-type zinc finger.
genes like me logo Genes that share domains with RUFY4: view

Function for RUFY4 Gene

Gene Ontology (GO) - Molecular Function for RUFY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RUFY4: view
genes like me logo Genes that share phenotypes with RUFY4: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RUFY4 Gene

Localization for RUFY4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RUFY4 Gene COMPARTMENTS Subcellular localization image for RUFY4 gene
Compartment Confidence
nucleus 3
cytosol 2
endosome 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RUFY4 Gene

Pathways & Interactions for RUFY4 Gene

SuperPathways for RUFY4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RUFY4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RUFY4 Gene

Drugs & Compounds for RUFY4 Gene

No Compound Related Data Available

Transcripts for RUFY4 Gene

mRNA/cDNA for RUFY4 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RUFY4 Gene

RUN and FYVE domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RUFY4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - -
SP2: -
SP3: - -
SP4: -
SP5: - - -
SP6:
SP7: - - -
SP8: - -

Relevant External Links for RUFY4 Gene

GeneLoc Exon Structure for
RUFY4
ECgene alternative splicing isoforms for
RUFY4

Expression for RUFY4 Gene

mRNA expression in normal human tissues for RUFY4 Gene

mRNA differential expression in normal tissues according to GTEx for RUFY4 Gene

This gene is overexpressed in Spleen (x5.2).

Protein differential expression in normal tissues from HIPED for RUFY4 Gene

This gene is overexpressed in Plasma (42.1) and Breast (25.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RUFY4 Gene



SOURCE GeneReport for Unigene cluster for RUFY4 Gene Hs.570069

genes like me logo Genes that share expression patterns with RUFY4: view

Protein tissue co-expression partners for RUFY4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RUFY4 Gene

Orthologs for RUFY4 Gene

This gene was present in the common ancestor of animals.

Orthologs for RUFY4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RUFY4 35
  • 97.57 (n)
  • 95.8 (a)
RUFY4 36
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGC157327 36
  • 62 (a)
OneToOne
RUFY4 35
  • 81.52 (n)
  • 72.46 (a)
dog
(Canis familiaris)
Mammalia RUFY4 35
  • 79.58 (n)
  • 69.19 (a)
RUFY4 36
  • 54 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rufy4 16
Rufy4 35
  • 74.32 (n)
  • 62.99 (a)
Rufy4 36
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RUFY4 36
  • 37 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rufy4 35
  • 74.85 (n)
  • 62.99 (a)
chicken
(Gallus gallus)
Aves RUFY4 35
  • 65.92 (n)
  • 56.74 (a)
RUFY4 36
  • 26 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RUFY4 36
  • 15 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4030 36
  • 6 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rabn-5 36
  • 11 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 14 (a)
OneToMany
Species with no ortholog for RUFY4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RUFY4 Gene

ENSEMBL:
Gene Tree for RUFY4 (if available)
TreeFam:
Gene Tree for RUFY4 (if available)

Paralogs for RUFY4 Gene

Paralogs for RUFY4 Gene

genes like me logo Genes that share paralogs with RUFY4: view

Variants for RUFY4 Gene

Sequence variations from dbSNP and Humsavar for RUFY4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs934042 -- 218,035,495(+) CATGC(C/T)CCAGC intron-variant
rs934043 -- 218,035,572(+) GCCAC(A/C/G)CCACC intron-variant
rs934044 -- 218,042,439(-) TCTGT(A/T)TTTCT intron-variant
rs934045 -- 218,042,265(-) TCAGG(C/T)ACTAC intron-variant
rs1427670 -- 218,050,935(-) TATTC(C/T)ATTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RUFY4 Gene

Variant ID Type Subtype PubMed ID
nsv834541 CNV Loss 17160897
nsv3163 CNV Insertion 18451855
esv2721477 CNV Deletion 23290073
nsv512786 CNV Insertion 21212237
esv2494137 CNV Insertion 19546169

Variation tolerance for RUFY4 Gene

Gene Damage Index Score: 4.22; 62.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RUFY4 Gene

HapMap Linkage Disequilibrium report
RUFY4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RUFY4 Gene

Disorders for RUFY4 Gene

Relevant External Links for RUFY4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RUFY4

No disorders were found for RUFY4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RUFY4 Gene

Publications for RUFY4 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for RUFY4 Gene

Sources for RUFY4 Gene

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