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Aliases for RUFY4 Gene

Aliases for RUFY4 Gene

  • RUN And FYVE Domain Containing 4 2 3
  • RUN And FYVE Domain-Containing Protein 4 3
  • ZFYVE31 3

External Ids for RUFY4 Gene

Previous GeneCards Identifiers for RUFY4 Gene

  • GC02P218607
  • GC02P218899
  • GC02P210753

Summaries for RUFY4 Gene

GeneCards Summary for RUFY4 Gene

RUFY4 (RUN And FYVE Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is FYCO1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RUFY4 Gene

Genomics for RUFY4 Gene

Regulatory Elements for RUFY4 Gene

Genomic Location for RUFY4 Gene

Start:
218,034,934 bp from pter
End:
218,090,581 bp from pter
Size:
55,648 bases
Orientation:
Plus strand

Genomic View for RUFY4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RUFY4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RUFY4 Gene

Proteins for RUFY4 Gene

  • Protein details for RUFY4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNE9-RUFY4_HUMAN
    Recommended name:
    RUN and FYVE domain-containing protein 4
    Protein Accession:
    Q6ZNE9
    Secondary Accessions:
    • Q6ZR96

    Protein attributes for RUFY4 Gene

    Size:
    571 amino acids
    Molecular mass:
    64350 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI13713.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC87417.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for RUFY4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RUFY4 Gene

Proteomics data for RUFY4 Gene at MOPED

Post-translational modifications for RUFY4 Gene

No Post-translational modifications

Other Protein References for RUFY4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RUFY4 Gene

Domains for RUFY4 Gene

Gene Families for RUFY4 Gene

HGNC:
  • ZFYVE :Zinc fingers, FYVE domain containing

Protein Domains for RUFY4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RUFY4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZNE9

UniProtKB/Swiss-Prot:

RUFY4_HUMAN :
  • Q6ZNE9
Domain:
  • Contains 1 RUN domain.
Similarity:
  • Contains 1 FYVE-type zinc finger.
genes like me logo Genes that share domains with RUFY4: view

Function for RUFY4 Gene

Gene Ontology (GO) - Molecular Function for RUFY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RUFY4: view
genes like me logo Genes that share phenotypes with RUFY4: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RUFY4 Gene

Localization for RUFY4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RUFY4 Gene COMPARTMENTS Subcellular localization image for RUFY4 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RUFY4 Gene

Pathways for RUFY4 Gene

SuperPathways for RUFY4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RUFY4 Gene

None

No data available for Pathways by source for RUFY4 Gene

Transcripts for RUFY4 Gene

mRNA/cDNA for RUFY4 Gene

(11) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RUFY4 Gene

RUN and FYVE domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RUFY4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - -
SP2: -
SP3: - -
SP4: -
SP5: - - -
SP6:
SP7: - - -
SP8: - -

Relevant External Links for RUFY4 Gene

GeneLoc Exon Structure for
RUFY4
ECgene alternative splicing isoforms for
RUFY4

Expression for RUFY4 Gene

mRNA expression in normal human tissues for RUFY4 Gene

mRNA differential expression in normal tissues according to GTEx for RUFY4 Gene

This gene is overexpressed in Spleen (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RUFY4 Gene

SOURCE GeneReport for Unigene cluster for RUFY4 Gene Hs.570069

genes like me logo Genes that share expressions with RUFY4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RUFY4 Gene

Orthologs for RUFY4 Gene

This gene was present in the common ancestor of animals.

Orthologs for RUFY4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RUFY4 35
  • 97.57 (n)
  • 95.8 (a)
RUFY4 36
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGC157327 36
  • 62 (a)
OneToOne
RUFY4 35
  • 81.52 (n)
  • 72.46 (a)
dog
(Canis familiaris)
Mammalia RUFY4 35
  • 79.58 (n)
  • 69.19 (a)
RUFY4 36
  • 54 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rufy4 35
  • 74.32 (n)
  • 62.99 (a)
Rufy4 16
Rufy4 36
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RUFY4 36
  • 37 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rufy4 35
  • 74.85 (n)
  • 62.99 (a)
chicken
(Gallus gallus)
Aves RUFY4 35
  • 65.92 (n)
  • 56.74 (a)
RUFY4 36
  • 26 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RUFY4 36
  • 15 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4030 36
  • 6 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rabn-5 36
  • 11 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 14 (a)
OneToMany
Species with no ortholog for RUFY4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RUFY4 Gene

ENSEMBL:
Gene Tree for RUFY4 (if available)
TreeFam:
Gene Tree for RUFY4 (if available)

Paralogs for RUFY4 Gene

Paralogs for RUFY4 Gene

genes like me logo Genes that share paralogs with RUFY4: view

Variants for RUFY4 Gene

Sequence variations from dbSNP and Humsavar for RUFY4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs730232 -- 218,034,950(+) GCAGG(G/T)GCTGA nc-transcript-variant
rs730233 -- 218,034,910(+) TCCCT(C/G)TGCCC upstream-variant-2KB
rs735212 -- 218,041,697(+) TTGAG(A/G)TAAGT intron-variant
rs744271 -- 218,035,058(+) CATCC(C/T)CCATC nc-transcript-variant
rs934042 -- 218,035,495(+) CATGC(C/T)CCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RUFY4 Gene

Variant ID Type Subtype PubMed ID
nsv834541 CNV Loss 17160897
nsv3163 CNV Insertion 18451855
esv2721477 CNV Deletion 23290073
nsv512786 CNV Insertion 21212237
esv2494137 CNV Insertion 19546169

Relevant External Links for RUFY4 Gene

HapMap Linkage Disequilibrium report
RUFY4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RUFY4 Gene

Disorders for RUFY4 Gene

No disorders were found for RUFY4 Gene.

No data available for UniProtKB/Swiss-Prot for RUFY4 Gene

Publications for RUFY4 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for RUFY4 Gene

Sources for RUFY4 Gene

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