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Aliases for RUFY3 Gene

Aliases for RUFY3 Gene

  • RUN And FYVE Domain Containing 3 2 3
  • RIPX 3 4 6
  • Single Axon-Regulated Protein 3 4
  • Single Axon-Related 1 2 3
  • SINGAR1 3 6
  • Rap2 Interacting Protein X 3
  • Rap2-Interacting Protein X 4
  • Protein RUFY3 3
  • KIAA0871 4
  • ZFYVE30 3
  • Singar 4

External Ids for RUFY3 Gene

Previous GeneCards Identifiers for RUFY3 Gene

  • GC04P071953
  • GC04P071806
  • GC04P071570
  • GC04P067374
  • GC04P071571
  • GC04P071573

Summaries for RUFY3 Gene

GeneCards Summary for RUFY3 Gene

RUFY3 (RUN And FYVE Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is RUFY2.

UniProtKB/Swiss-Prot for RUFY3 Gene

  • Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RUFY3 Gene

Genomics for RUFY3 Gene

Regulatory Elements for RUFY3 Gene

Genomic Location for RUFY3 Gene

70,704,204 bp from pter
70,808,619 bp from pter
104,416 bases
Plus strand

Genomic View for RUFY3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RUFY3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RUFY3 Gene

Proteins for RUFY3 Gene

  • Protein details for RUFY3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein RUFY3
    Protein Accession:
    Secondary Accessions:
    • B3KM25
    • B4DYW7
    • D9N163
    • O94948
    • Q9UI00

    Protein attributes for RUFY3 Gene

    469 amino acids
    Molecular mass:
    52965 Da
    Quaternary structure:
    • Interacts with PIK3CA and PIK3R1.
    • Sequence=BAA74894.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RUFY3 Gene


neXtProt entry for RUFY3 Gene

Proteomics data for RUFY3 Gene at MOPED

Post-translational modifications for RUFY3 Gene

No data available for DME Specific Peptides for RUFY3 Gene

Domains for RUFY3 Gene

Gene Families for RUFY3 Gene

  • ZFYVE :Zinc fingers, FYVE domain containing

Protein Domains for RUFY3 Gene


Suggested Antigen Peptide Sequences for RUFY3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q7L099
  • Contains 1 RUN domain.
genes like me logo Genes that share domains with RUFY3: view

Function for RUFY3 Gene

Molecular function for RUFY3 Gene

UniProtKB/Swiss-Prot Function: Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity).

Gene Ontology (GO) - Molecular Function for RUFY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RUFY3: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RUFY3 Gene

Localization for RUFY3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RUFY3 Gene

Cell projection. Note=Enriched in F-actin enriched filopodia and lamellipodia of growth cones of axons and minor processes of hippocampal neurons in culture. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for RUFY3 Gene COMPARTMENTS Subcellular localization image for RUFY3 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RUFY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030175 filopodium ISS --
GO:0030426 growth cone ISS --
genes like me logo Genes that share ontologies with RUFY3: view

Pathways for RUFY3 Gene

SuperPathways for RUFY3 Gene

No Data Available

Interacting Proteins for RUFY3 Gene

Gene Ontology (GO) - Biological Process for RUFY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050771 negative regulation of axonogenesis ISS --
genes like me logo Genes that share ontologies with RUFY3: view

No data available for Pathways by source for RUFY3 Gene

Transcripts for RUFY3 Gene

Unigene Clusters for RUFY3 Gene

RUN and FYVE domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RUFY3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b
SP1: - - - - - - -
SP2: - - - - -
SP4: - - -
SP5: - -
SP6: - -
SP7: -
SP8: - - -

Relevant External Links for RUFY3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RUFY3 Gene

mRNA expression in normal human tissues for RUFY3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RUFY3 Gene

SOURCE GeneReport for Unigene cluster for RUFY3 Gene Hs.740904

genes like me logo Genes that share expressions with RUFY3: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RUFY3 Gene

Orthologs for RUFY3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RUFY3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RUFY3 35
  • 99.78 (n)
  • 99.84 (a)
RUFY3 36
  • 100 (a)
(Bos Taurus)
Mammalia RUFY3 36
  • 77 (a)
(Canis familiaris)
Mammalia RUFY3 35
  • 93.76 (n)
  • 95.65 (a)
RUFY3 36
  • 95 (a)
(Mus musculus)
Mammalia Rufy3 35
  • 90.64 (n)
  • 98.65 (a)
Rufy3 16
Rufy3 36
  • 95 (a)
(Monodelphis domestica)
Mammalia RUFY3 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia RUFY3 36
  • 90 (a)
(Rattus norvegicus)
Mammalia Rufy3 35
  • 91.31 (n)
  • 99.1 (a)
(Gallus gallus)
Aves RUFY3 35
  • 81.45 (n)
  • 86.89 (a)
RUFY3 36
  • 85 (a)
(Anolis carolinensis)
Reptilia RUFY3 36
  • 82 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8516 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rufy3 35
  • 79.93 (n)
  • 91.24 (a)
Str.9922 35
(Danio rerio)
Actinopterygii rufy3 35
  • 76.58 (n)
  • 83.78 (a)
rufy3 36
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31064 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
Species with no ortholog for RUFY3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RUFY3 Gene

Gene Tree for RUFY3 (if available)
Gene Tree for RUFY3 (if available)

Paralogs for RUFY3 Gene

Paralogs for RUFY3 Gene

Selected SIMAP similar genes for RUFY3 Gene using alignment to 7 proteins: Pseudogenes for RUFY3 Gene

genes like me logo Genes that share paralogs with RUFY3: view

Variants for RUFY3 Gene

Sequence variations from dbSNP and Humsavar for RUFY3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs6934 -- 70,793,404(-) AATAG(A/G)TTTGG intron-variant, utr-variant-3-prime
rs11799 -- 70,793,086(-) TTCTA(A/C)ATATC intron-variant, utr-variant-3-prime
rs714223 -- 70,808,997(-) TGGCC(A/G)GGTTG intron-variant, downstream-variant-500B
rs714224 -- 70,809,047(-) ATTTA(G/T)TTAGT intron-variant, downstream-variant-500B
rs872948 -- 70,705,586(-) GAGGC(C/T)GGCGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RUFY3 Gene

Variant ID Type Subtype PubMed ID
nsv829965 CNV Gain 17160897
nsv4380 CNV Insertion 18451855
nsv819488 CNV Loss 19587683
nsv829966 CNV Loss 17160897

Relevant External Links for RUFY3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RUFY3 Gene

Disorders for RUFY3 Gene

Relevant External Links for RUFY3

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with RUFY3: view

No data available for UniProtKB/Swiss-Prot for RUFY3 Gene

Publications for RUFY3 Gene

  1. Singar1, a novel RUN domain-containing protein, suppresses formation of surplus axons for neuronal polarity. (PMID: 17439943) Mori T. … Inagaki N. (J. Biol. Chem. 2007) 2 3
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for RUFY3 Gene

Sources for RUFY3 Gene

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