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RUFY3 Gene

protein-coding   GIFtS: 47
GCID: GC04P071573

RUN And FYVE Domain Containing 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RUN And FYVE Domain Containing 31 2     Protein RUFY32
Single Axon-Related 11 2     Rap2 Interacting Protein X2
Rap2-Interacting Protein X2 3     singar2
Single Axon-Regulated Protein2 3     KIAA08713
RIPX2 5     RIPx3
SINGAR12 5     Singar3

External Ids:    HGNC: 302851   Entrez Gene: 229022   Ensembl: ENSG000000181897   OMIM: 6111945   UniProtKB: Q7L0993   

Export aliases for RUFY3 gene to outside databases

Previous GC identifers: GC04P071953 GC04P071806 GC04P071570 GC04P067374 GC04P071571


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RUFY3 Gene:
RUFY3 (RUN and FYVE domain containing 3) is a protein-coding gene. Diseases associated with RUFY3 include malignant fibroxanthoma, and prader-willi syndrome. An important paralog of this gene is RUNDC3A.

UniProtKB/Swiss-Prot: RUFY3_HUMAN, Q7L099
Function: Implicated in the formation of a single axon by developing neurons. May inhibit the formation of
additional axons by inhibition of PI3K in minor neuronal processes (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the RUFY3 gene promoter:
         FOXI1   HFH-3   HEN1   POU2F1   POU2F1a   STAT3   HNF-3beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRUFY3 promoter sequence
   Search Chromatin IP Primers for RUFY3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RUFY3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

RUFY3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RUFY3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P071573:  view genomic region     (about GC identifiers)

Start:
71,569,921 bp from pter      End:
71,674,336 bp from pter
Size:
104,416 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RUFY3_HUMAN, Q7L099 (See protein sequence)
Recommended Name: Protein RUFY3  
Size: 469 amino acids; 52965 Da
Subunit: Interacts with PIK3CA and PIK3R1 (By similarity)
Sequence caution: Sequence=BAA74894.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KM25 B4DYW7 D9N163 O94948 Q9UI00
Alternative splicing: 4 isoforms:  Q7L099-1   Q7L099-2   Q7L099-3   Q7L099-4   (Ref.2 (BAG63879) sequence is in conflict in positions: 304:L->S, 431:R->G)

Explore the universe of human proteins at neXtProt for RUFY3: NX_Q7L099

Explore proteomics data for RUFY3 at MOPED

Post-translational modifications: 

  • Isoform 1 is partially phosphorylated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RUFY3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001032519.1  NP_001124181.1  NP_055776.1  

    ENSEMBL proteins: 
     ENSP00000426165   ENSP00000426734   ENSP00000399771   ENSP00000370394   ENSP00000226328  
     ENSP00000425574   ENSP00000425400   ENSP00000421120   ENSP00000420980   ENSP00000443652  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFYVE: Zinc fingers, FYVE domain containing

    1 InterPro protein domain:
     IPR004012 Run

    Graphical View of Domain Structure for InterPro Entry Q7L099

    ProtoNet protein and cluster: Q7L099

    UniProtKB/Swiss-Prot: RUFY3_HUMAN, Q7L099
    Similarity: Contains 1 RUN domain


    RUFY3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RUFY3_HUMAN, Q7L099
    Function: Implicated in the formation of a single axon by developing neurons. May inhibit the formation of
    additional axons by inhibition of PI3K in minor neuronal processes (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0046872metal ion binding ----
         
    RUFY3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RUFY3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RUFY3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RUFY3

    miRNA
    Products:
        
    miRTarBase miRNAs that target RUFY3:
    hsa-mir-21-5p (MIRT030979), hsa-mir-124-3p (MIRT022964), hsa-mir-505-3p (MIRT041031), hsa-mir-192-5p (MIRT026779), hsa-mir-215-5p (MIRT024652)

    Block miRNA regulation of human, mouse, rat RUFY3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RUFY3 (see all 38):
    hsa-let-7d hsa-miR-513a-5p hsa-miR-139-5p hsa-miR-128 hsa-miR-29b-1* hsa-miR-502-3p hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidRUFY3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RUFY3

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    GenScript: all cDNA clones in your preferred vector (see all 3): RUFY3 (NM_001130709)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RUFY3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUFY3

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    Browse ESI BIO Cell Lines and PureStem Progenitors for RUFY3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUFY3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RUFY3_HUMAN, Q7L099: Cell projection (By similarity). Note=Enriched in F-actin enriched filopodia and
    lamellipodia of growth cones of axons and minor processes of hippocampal neurons in culture (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030175filopodium ISS--
    GO:0030426growth cone ISS--

    RUFY3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RUFY3
    Interactions:

        Search GeneGlobe Interaction Network for RUFY3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for RUFY3 (Q7L0992, 3 ENSP000003703944) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UNC119Q134322, 3MINT-64753 I2D: score=5 
    FOXK1ENSP000003287204STRING: ENSP00000328720
    MAP4ENSP000003533754STRING: ENSP00000353375
    KIF5BENSP000003070784STRING: ENSP00000307078
    LMNAENSP000003572834STRING: ENSP00000357283
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0050771negative regulation of axonogenesis ISS--

    RUFY3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RUFY3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RUFY3 gene (3 alternative transcripts): 
    NM_001037442.2  NM_001130709.1  NM_014961.3  

    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514898 ENST00000503876 ENST00000417478(uc003hfp.4) ENST00000381006(uc003hfr.3 uc011cay.2)
    ENST00000226328(uc003hfq.3 uc011cax.2) ENST00000513597 ENST00000502653
    ENST00000504805 ENST00000512103 ENST00000507333 ENST00000503025 ENST00000512331
    ENST00000515479 ENST00000515442 ENST00000513593 ENST00000536664
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RUFY3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RUFY3 (see all 38):
    hsa-let-7d hsa-miR-513a-5p hsa-miR-139-5p hsa-miR-128 hsa-miR-29b-1* hsa-miR-502-3p hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidRUFY3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RUFY3
    Predesigned siRNA for gene silencing in human, mouse, rat RUFY3
    Clone
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    OriGene clones in human, mouse for RUFY3 (see all 17)
    OriGene ORF clones in mouse, rat for RUFY3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RUFY3 (NM_001130709)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RUFY3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUFY3
    Primer
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    OriGene qPCR primer pairs and template standards for RUFY3
    OriGene qSTAR qPCR primer pairs in human, mouse for RUFY3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RUFY3
      QuantiTect SYBR Green Assays in human, mouse, rat RUFY3
      QuantiFast Probe-based Assays in human, mouse, rat RUFY3

    Selected AceView cDNA sequences (see all 353):

    N80059 BQ716425 BM509255 BQ268881 AA514623 BQ288034 BM565498 AA379994 
    AI088726 BM920380 CD107089 AI814929 AA989122 BQ061064 AA912270 AI092799 
    CD676941 CA397203 BU622102 AI131059 AW956545 AA290805 BM678618 AA343388 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RUFY3 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b
    SP1:              -     -     -           -                                                                                   -     -     -                     
    SP2:              -     -     -           -                                                                                   -                                 
    SP3:                                                                                                                                                            
    SP4:              -     -                 -                                                                                                                     
    SP5:                          -           -                                                                                                                     


    ECgene alternative splicing isoforms for RUFY3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RUFY3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RUFY3 Expression
    About this image


    RUFY3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord
    RUFY3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RUFY3 Protein Expression
        Custom PCR Arrays for RUFY3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUFY3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RUFY3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rufy31 , 5 RUN and FYVE domain containing 31, 5 90.64(n)1
    98.65(a)1
      5 (43.77 cM)5
    528221  NM_027530.21  NP_081806.11 
     885835745 
    chicken
    (Gallus gallus)
    Aves RUFY31 RUN and FYVE domain containing 3 81.45(n)
    86.89(a)
      422645  XM_004941177.1  XP_004941234.1 
    lizard
    (Anolis carolinensis)
    Reptilia RUFY36
    RUN and FYVE domain containing 3
    82(a)
    1 ↔ 1
    5(147115601-147159561)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.85162 Xenopus laevis transcribed sequence with moderate similarity more 78.69(n)    BQ736314.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rufy31 RUN and FYVE domain containing 3 76.58(n)
    83.78(a)
      541522  NM_001014335.2  NP_001014357.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG310646
    --
    27(a)
    1 → many
    3R(23055227-23064803)


    ENSEMBL Gene Tree for RUFY3 (if available)
    TreeFam Gene Tree for RUFY3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RUFY3 gene
    RUNDC3A2  RUFY22  RUNDC3B2  RUFY12  
    2 SIMAP similar genes for RUFY3 using alignment to 7 protein entries:     RUFY3_HUMAN (see all proteins):
    RUFY2    RUFY1

    RUFY3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RUFY3
    PGOHUM00000235345


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RUFY3 (see all 2014)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1468661001,2
    --71568725(+) TAATAA/GTAATT 1 -- us2k10--------
    rs1888432101,2
    --71568779(+) GTGCAA/GGGAAA 1 -- us2k10--------
    rs1407185891,2
    C--71568968(+) TCCTGC/GCTCAG 1 -- us2k10--------
    rs1504955061,2
    --71569006(+) CTCGCA/CACCAC 1 -- us2k10--------
    rs1451817471,2
    --71569012(+) ACCACA/GCCCAG 1 -- us2k10--------
    rs1432754331,2
    --71569248(+) ACATAA/GTCATT 1 -- us2k10--------
    rs285571191,2
    C,F--71569379(+) TTTCCT/CTTTTG 1 -- us2k14Minor allele frequency- C:0.30WA CSA 123
    rs1391584761,2
    --71569420(+) GTAGTA/GTTGTA 1 -- us2k10--------
    rs1435881221,2
    --71569602(+) TTAATA/TATGAG 1 -- us2k10--------
    rs1459664091,2
    C--71569631(+) CAGCAC/TTAAAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RUFY3 (71569921 - 71674336 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RUFY3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4380CNV Insertion18451855
    nsv819488CNV Loss19587683
    nsv829966CNV Loss17160897
    nsv829965CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RUFY3
    DNA2.0 Custom Variant and Variant Library Synthesis for RUFY3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611194    OMIM disorders: --

    7 diseases for RUFY3:    
    About MalaCards
    malignant fibroxanthoma    prader-willi syndrome    sinusitis    parkinson's disease
    neuronitis    cerebritis    malaria


    RUFY3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RUFY3

    Export disorders for RUFY3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RUFY3 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with RUFY3)
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    1. Singar1, a novel RUN domain-containing protein, suppresses formation of surplus axons for neuronal polarity. (PubMed id 17439943)1, 3 Mori T....Inagaki N. (J. Biol. Chem. 2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    5. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Rab5(Q79L) interacts with the carboxyl terminus of RUFY3. (PubMed id 20376209)1 Yoshida H....Matsuda S. (Int. J. Biol. Sci. 2010)
    9. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PubMed id 17903297)4 Seshadri S....Wolf P.A. (BMC Med. Genet. 2007)
    10. Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes. (PubMed id 17903304)4 Larson M.G....Levy D. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22902 HGNC: 30285 AceView: RIPX Ensembl:ENSG00000018189 euGenes: HUgn22902
    ECgene: RUFY3 H-InvDB: RUFY3

    (According to HUGE)
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    HUGE: KIAA0871

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RUFY3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RUFY3 gene:
    Search GeneIP for patents involving RUFY3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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