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Aliases for RUFY3 Gene

Aliases for RUFY3 Gene

  • RUN And FYVE Domain Containing 3 2 3 5
  • RUN And FYVE Domain-Containing Protein 3 3 4
  • Single Axon-Regulated Protein 3 4
  • Single Axon-Related 1 2 3
  • RIPX 3 4
  • Rap2 Interacting Protein X 3
  • Rap2-Interacting Protein X 4
  • KIAA0871 4
  • SINGAR1 3
  • ZFYVE30 3
  • Singar 4

External Ids for RUFY3 Gene

Previous GeneCards Identifiers for RUFY3 Gene

  • GC04P071953
  • GC04P071806
  • GC04P071570
  • GC04P067374
  • GC04P071571
  • GC04P071573

Summaries for RUFY3 Gene

GeneCards Summary for RUFY3 Gene

RUFY3 (RUN And FYVE Domain Containing 3) is a Protein Coding gene. Diseases associated with RUFY3 include gastric cancer. An important paralog of this gene is RUFY2.

UniProtKB/Swiss-Prot for RUFY3 Gene

  • Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (PubMed:25766321). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity). Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner (PubMed:25766321).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RUFY3 Gene

Genomics for RUFY3 Gene

Regulatory Elements for RUFY3 Gene

Promoters for RUFY3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RUFY3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RUFY3 Gene

Chromosome:
4
Start:
70,704,204 bp from pter
End:
70,808,622 bp from pter
Size:
104,419 bases
Orientation:
Plus strand

Genomic View for RUFY3 Gene

Genes around RUFY3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RUFY3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RUFY3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RUFY3 Gene

Proteins for RUFY3 Gene

  • Protein details for RUFY3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L099-RUFY3_HUMAN
    Recommended name:
    Protein RUFY3
    Protein Accession:
    Q7L099
    Secondary Accessions:
    • B3KM25
    • B4DYW7
    • D9N163
    • O94948
    • Q9UI00

    Protein attributes for RUFY3 Gene

    Size:
    469 amino acids
    Molecular mass:
    52965 Da
    Quaternary structure:
    • Interacts with PAK1 (PubMed:25766321). Interacts (via C-terminus) with Ras-related Rab-5 proteins (PubMed:20376209). Interacts (via C-terminus) with Ras-related Rap-2 proteins (PubMed:20376209). Interacts with PIK3CA and PIK3R1 (By similarity). Interacts (via N-terminus) with FSCN1; this interaction induces neuron axon development (By similarity). Interacts with DBN1 (By similarity).
    SequenceCaution:
    • Sequence=BAA74894.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RUFY3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RUFY3 Gene

Proteomics data for RUFY3 Gene at MOPED

Post-translational modifications for RUFY3 Gene

  • Phosphorylated by PAK1 (PubMed:25766321). Isoform 1 is partially phosphorylated (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for RUFY3 Gene

Domains & Families for RUFY3 Gene

Gene Families for RUFY3 Gene

Protein Domains for RUFY3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RUFY3 Gene

Graphical View of Domain Structure for InterPro Entry

Q7L099

UniProtKB/Swiss-Prot:

RUFY3_HUMAN :
  • Contains 1 RUN domain.
Domain:
  • Contains 1 RUN domain.
genes like me logo Genes that share domains with RUFY3: view

Function for RUFY3 Gene

Molecular function for RUFY3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (PubMed:25766321). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity). Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner (PubMed:25766321).
genes like me logo Genes that share phenotypes with RUFY3: view

Animal Models for RUFY3 Gene

MGI Knock Outs for RUFY3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RUFY3 Gene

Localization for RUFY3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RUFY3 Gene

Cytoplasm. Endomembrane system. Cell projection, invadopodium. Perikaryon. Cell projection. Cell projection, growth cone. Cell projection, filopodium. Cell projection, lamellipodium. Note=Colocalizes with PAK1, F-actin, myosins and integrins in invadopodia at the cell periphery (PubMed:25766321). Colocalized with Ras-related Rab-5 proteins in cytoplasmic vesicles (PubMed:20376209). Accumulates in axon growth cones in a F-actin-dependent manner (By similarity). Colocalized with FSCN1 and F-actin at filipodia and lamellipodia of axonal growth cones (By similarity). Colocalized with DBN1 and F-actin at transitional domain of the axonal growth cone (By similarity). {ECO:0000250 UniProtKB:Q5FVJ0, ECO:0000250 UniProtKB:Q9D394, ECO:0000269 PubMed:20376209, ECO:0000269 PubMed:25766321}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RUFY3 Gene COMPARTMENTS Subcellular localization image for RUFY3 gene
Compartment Confidence
cytosol 3
nucleus 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RUFY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 25766321
GO:0030027 lamellipodium ISS --
GO:0030054 cell junction IEA --
GO:0030425 dendrite ISS --
GO:0071437 invadopodium IDA 25766321
genes like me logo Genes that share ontologies with RUFY3: view

Pathways & Interactions for RUFY3 Gene

SuperPathways for RUFY3 Gene

No Data Available

Interacting Proteins for RUFY3 Gene

Gene Ontology (GO) - Biological Process for RUFY3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RUFY3 Gene

Drugs & Compounds for RUFY3 Gene

No Compound Related Data Available

Transcripts for RUFY3 Gene

Unigene Clusters for RUFY3 Gene

RUN and FYVE domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RUFY3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b
SP1: - - - - - - -
SP2: - - - - -
SP3:
SP4: - - -
SP5: - -
SP6: - -
SP7: -
SP8: - - -

Relevant External Links for RUFY3 Gene

GeneLoc Exon Structure for
RUFY3
ECgene alternative splicing isoforms for
RUFY3

Expression for RUFY3 Gene

mRNA expression in normal human tissues for RUFY3 Gene

Protein differential expression in normal tissues from HIPED for RUFY3 Gene

This gene is overexpressed in Frontal cortex (17.2), Fetal Brain (14.7), Spinal cord (11.6), and Brain (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RUFY3 Gene



SOURCE GeneReport for Unigene cluster for RUFY3 Gene Hs.740904

mRNA Expression by UniProt/SwissProt for RUFY3 Gene

Q7L099-RUFY3_HUMAN
Tissue specificity: Overexpressed in gastric cancer cells and tissues (at protein level) (PubMed:25766321).
genes like me logo Genes that share expression patterns with RUFY3: view

Protein tissue co-expression partners for RUFY3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RUFY3 Gene

Orthologs for RUFY3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RUFY3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia RUFY3 35
  • 93.76 (n)
  • 95.65 (a)
RUFY3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rufy3 35
  • 90.64 (n)
  • 98.65 (a)
Rufy3 16
Rufy3 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RUFY3 35
  • 99.78 (n)
  • 99.84 (a)
RUFY3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rufy3 35
  • 91.31 (n)
  • 99.1 (a)
cow
(Bos Taurus)
Mammalia RUFY3 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RUFY3 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RUFY3 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves RUFY3 35
  • 81.45 (n)
  • 86.89 (a)
RUFY3 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RUFY3 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rufy3 35
  • 79.93 (n)
  • 91.24 (a)
Str.9922 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8516 35
zebrafish
(Danio rerio)
Actinopterygii rufy3 35
  • 76.58 (n)
  • 83.78 (a)
rufy3 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31064 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for RUFY3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RUFY3 Gene

ENSEMBL:
Gene Tree for RUFY3 (if available)
TreeFam:
Gene Tree for RUFY3 (if available)

Paralogs for RUFY3 Gene

Paralogs for RUFY3 Gene

(2) SIMAP similar genes for RUFY3 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for RUFY3 Gene

genes like me logo Genes that share paralogs with RUFY3: view

Variants for RUFY3 Gene

Sequence variations from dbSNP and Humsavar for RUFY3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs6934 -- 70,793,404(-) AATAG(A/G)TTTGG intron-variant, utr-variant-3-prime
rs11799 -- 70,793,086(-) TTCTA(A/C)ATATC intron-variant, utr-variant-3-prime
rs714223 -- 70,808,997(-) TGGCC(A/G)GGTTG downstream-variant-500B
rs714224 -- 70,809,047(-) ATTTA(G/T)TTAGT downstream-variant-500B
rs872948 -- 70,705,586(-) GAGGC(C/T)GGCGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RUFY3 Gene

Variant ID Type Subtype PubMed ID
nsv829965 CNV Gain 17160897
nsv4380 CNV Insertion 18451855
nsv819488 CNV Loss 19587683
nsv829966 CNV Loss 17160897

Variation tolerance for RUFY3 Gene

Residual Variation Intolerance Score: 32.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RUFY3 Gene

HapMap Linkage Disequilibrium report
RUFY3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RUFY3 Gene

Disorders for RUFY3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RUFY3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
gastric cancer
  • stomach cancer
- elite association - COSMIC cancer census association via MalaCards
Search RUFY3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RUFY3

Genetic Association Database (GAD)
RUFY3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RUFY3
genes like me logo Genes that share disorders with RUFY3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RUFY3 Gene

Publications for RUFY3 Gene

  1. PAK1 regulates RUFY3-mediated gastric cancer cell migration and invasion. (PMID: 25766321) Wang G. … Li F. (Cell Death Dis. 2015) 3 4 67
  2. Singar1, a novel RUN domain-containing protein, suppresses formation of surplus axons for neuronal polarity. (PMID: 17439943) Mori T. … Inagaki N. (J. Biol. Chem. 2007) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 3

Products for RUFY3 Gene

Sources for RUFY3 Gene

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