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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RUFY3 Gene

protein-coding   GIFtS: 50
GCID: GC04P071571

RUN And FYVE Domain Containing 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RUN And FYVE Domain Containing 31 2     Protein RUFY32
Single Axon-Related 11 2     Rap2 Interacting Protein X2
Rap2-Interacting Protein X2 3     singar2
Single Axon-Regulated Protein2 3     KIAA08713
RIPX2     RIPx3
SINGAR12     Singar3

External Ids:    HGNC: 302851   Entrez Gene: 229022   Ensembl: ENSG000000181897   OMIM: 6111945   UniProtKB: Q7L0993   

Export aliases for RUFY3 gene to outside databases

Previous GC identifers: GC04P071953 GC04P071806 GC04P071570 GC04P067374


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RUFY3 Gene: 
RUFY3 (RUN and FYVE domain containing 3) is a protein-coding gene. Diseases associated with RUFY3 include malignant fibroxanthoma, and prader-willi syndrome. An important paralog of this gene is RUNDC3A.

UniProtKB/Swiss-Prot: RUFY3_HUMAN, Q7L099
Function: Implicated in the formation of a single axon by developing neurons. May inhibit the formation of
additional axons by inhibition of PI3K in minor neuronal processes (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_022778.16  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RUFY3 gene promoter:
         FOXI1   HFH-3   HEN1   POU2F1   POU2F1a   STAT3   HNF-3beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRUFY3 promoter sequence
   Search SABiosciences Chromatin IP Primers for RUFY3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RUFY3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

RUFY3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RUFY3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P071571:  view genomic region     (about GC identifiers)

Start:
71,569,921 bp from pter      End:
71,674,336 bp from pter
Size:
104,416 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RUFY3_HUMAN, Q7L099 (See protein sequence)
Recommended Name: Protein RUFY3  
Size: 469 amino acids; 52965 Da
Subunit: Interacts with PIK3CA and PIK3R1 (By similarity)
Subcellular location: Cell projection (By similarity). Note=Enriched in F-actin enriched filopodia and
lamellipodia of growth cones of axons and minor processes of hippocampal neurons in culture (By similarity)
Sequence caution: Sequence=BAA74894.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KM25 B4DYW7 D9N163 O94948 Q9UI00
Alternative splicing: 4 isoforms:  Q7L099-1   Q7L099-2   Q7L099-3   Q7L099-4   (Ref.2 (BAG63879) sequence is in conflict in positions: 304:L->S, 431:R->G)

Explore the universe of human proteins at neXtProt for RUFY3: NX_Q7L099

Explore proteomics data for RUFY3 at MOPED 

Post-translational modifications:

  • UniProtKB: Isoform 1 is partially phosphorylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7L099

  • RUFY3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RUFY3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001032519.1  NP_001124181.1  NP_055776.1  

    ENSEMBL proteins: 
     ENSP00000426165   ENSP00000426734   ENSP00000399771   ENSP00000370394   ENSP00000226328  
     ENSP00000425574   ENSP00000425400   ENSP00000421120   ENSP00000420980   ENSP00000443652  

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    Cloud-Clone Corp. Proteins for RUFY3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030175filopodium ISS--
    GO:0030426growth cone ISS--

    RUFY3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZFYVE: Zinc fingers, FYVE domain containing

    1 InterPro protein domain:
     IPR004012 Run

    Graphical View of Domain Structure for InterPro Entry Q7L099

    ProtoNet protein and cluster: Q7L099

    UniProtKB/Swiss-Prot: RUFY3_HUMAN, Q7L099
    Similarity: Contains 1 RUN domain


    RUFY3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RUFY3_HUMAN, Q7L099
    Function: Implicated in the formation of a single axon by developing neurons. May inhibit the formation of
    additional axons by inhibition of PI3K in minor neuronal processes (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0046872metal ion binding ----
         
    RUFY3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RUFY3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RUFY3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RUFY3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RUFY3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RUFY3
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate RUFY3 (see all 38):
    hsa-let-7d hsa-miR-513a-5p hsa-miR-139-5p hsa-miR-128 hsa-miR-29b-1* hsa-miR-502-3p hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidRUFY3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RUFY3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/12 Interacting proteins for RUFY3 (Q7L0992, 3 ENSP000003703944) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UNC119Q134322, 3MINT-64753 I2D: score=5 
    FOXK1ENSP000003287204STRING: ENSP00000328720
    MAP4ENSP000003533754STRING: ENSP00000353375
    KIF5BENSP000003070784STRING: ENSP00000307078
    LMNAENSP000003572834STRING: ENSP00000357283
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0050771negative regulation of axonogenesis ISS--

    RUFY3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RUFY3

    Search CenterWatch for drugs/clinical trials and news about RUFY3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RUFY3 gene (3 alternative transcripts): 
    NM_001037442.2  NM_001130709.1  NM_014961.3  

    Unigene Cluster for RUFY3:

    RUN and FYVE domain containing 3
    Hs.740904  [show with all ESTs]
    Unigene Representative Sequence: NM_001037442
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514898 ENST00000503876 ENST00000417478(uc003hfp.4) ENST00000381006(uc003hfr.3 uc011cay.2)
    ENST00000226328(uc003hfq.3 uc011cax.2) ENST00000513597 ENST00000502653
    ENST00000504805 ENST00000512103 ENST00000507333 ENST00000503025 ENST00000512331
    ENST00000515479 ENST00000515442 ENST00000513593 ENST00000536664
    miRNA
    Products:
         
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    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate RUFY3 (see all 38):
    hsa-let-7d hsa-miR-513a-5p hsa-miR-139-5p hsa-miR-128 hsa-miR-29b-1* hsa-miR-502-3p hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidRUFY3 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUFY3
    Sirion Biotech Customized lentivirus for stable overexpression of RUFY3 
                         Customized lentivirus expression plasmids for stable overexpression of RUFY3 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RUFY3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RUFY3

    Additional mRNA sequence: 

    AB020678.1 AF112221.1 AK000911.1 AK021769.1 AK022074.1 AK294421.1 AK296501.1 AK302637.1 
    BC051716.1 BC053837.1 BC071988.1 BC098433.1 

    24/27 DOTS entries (see all 27):

    DT.100650958  DT.450798  DT.100793738  DT.40233954  DT.121231561  DT.95093666  DT.121231637  DT.40190998 
    DT.40283898  DT.91878373  DT.99971240  DT.121231581  DT.40284258  DT.92425876  DT.100699793  DT.100793739 
    DT.121231569  DT.121231588  DT.121231639  DT.92425872  DT.95093614  DT.95201665  DT.97845413  DT.100018239 

    24/353 AceView cDNA sequences (see all 353):

    BM675008 AI131059 BU625960 BU608384 BM717515 AA257146 AA514623 BM920380 
    AI917398 AA290805 AB020678 AA435606 T33158 BF433146 AA031445 AI241455 
    AI041549 AW206541 AI342000 BE220359 BM719426 BQ288034 BM509255 AA343389 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RUFY3 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b
    SP1:              -     -     -           -                                                                                   -     -     -                     
    SP2:              -     -     -           -                                                                                   -                                 
    SP3:                                                                                                                                                            
    SP4:              -     -                 -                                                                                                                     
    SP5:                          -           -                                                                                                                     


    ECgene alternative splicing isoforms for RUFY3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RUFY3 expression in normal human tissues (normalized intensities)      RUFY3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RUFY3 Expression
    About this image


    RUFY3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Thalamus
             Fetal Neuronal Stem Cells (NSC)   
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Neuron (Nervous System)
             Human Neurons   
     
     Lower Urinary Tract (Urinary System)
             visceral organ/urogenital sinus/nerves of urogenital sinus   

    See RUFY3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RUFY3

    SOURCE GeneReport for Unigene cluster: Hs.740904
        SABiosciences Custom PCR Arrays for RUFY3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUFY3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RUFY3 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rufy31 , 5 RUN and FYVE domain containing 31, 5 90.64(n)1
    98.65(a)1
      5 (43.77 cM)5
    528221  NM_027530.21  NP_081806.11 
     885835745 
    chicken
    (Gallus gallus)
    Aves RUFY31 RUN and FYVE domain containing 3 81.5(n)
    86.89(a)
      422645  XM_420599.3  XP_420599.2 
    lizard
    (Anolis carolinensis)
    Reptilia RUFY36
    RUN and FYVE domain containing 3
    82(a)
    1 ↔ 1
    5(147115601-147159561)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.85162 Xenopus laevis transcribed sequence with moderate similarity more 78.69(n)    BQ736314.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rufy31 RUN and FYVE domain containing 3 76.58(n)
    83.78(a)
      541522  NM_001014335.1  NP_001014357.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG310646
    --
    26(a)
    1 → many
    3R(23055227-23064803)


    ENSEMBL Gene Tree for RUFY3 (if available)
    TreeFam Gene Tree for RUFY3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RUFY3 gene
    RUNDC3A2  RUFY22  RUNDC3B2  RUFY12  
    2 SIMAP similar genes for RUFY3 using alignment to 7 protein entries:     RUFY3_HUMAN (see all proteins):
    RUFY2    RUFY1

    RUFY3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RUFY3
    PGOHUM00000235345


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2014 SNPs in RUFY3 are shown (see all 2014)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1468661001,2
    --71568725(+) TAATAA/GTAATT 1 -- us2k10--------
    rs1888432101,2
    --71568779(+) GTGCAA/GGGAAA 1 -- us2k10--------
    rs1407185891,2
    C--71568968(+) TCCTGC/GCTCAG 1 -- us2k10--------
    rs1504955061,2
    --71569006(+) CTCGCA/CACCAC 1 -- us2k10--------
    rs1451817471,2
    --71569012(+) ACCACA/GCCCAG 1 -- us2k10--------
    rs1432754331,2
    --71569248(+) ACATAA/GTCATT 1 -- us2k10--------
    rs285571191,2
    C,F--71569379(+) TTTCCT/CTTTTG 1 -- us2k14Minor allele frequency- C:0.30WA CSA 123
    rs1391584761,2
    --71569420(+) GTAGTA/GTTGTA 1 -- us2k10--------
    rs1435881221,2
    --71569602(+) TTAATA/TATGAG 1 -- us2k10--------
    rs1459664091,2
    C--71569631(+) CAGCAC/TTAAAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RUFY3 (71569921 - 71674336 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RUFY3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv4380CNV Insertion18451855
    nsv819488CNV Loss19587683
    nsv829966CNV Loss17160897
    nsv829965CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611194    OMIM disorders: --

    4 diseases for RUFY3:    About MalaCards
    malignant fibroxanthoma    prader-willi syndrome    gastric cancer    neuronitis


    RUFY3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RUFY3

    Export disorders for RUFY3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RUFY3 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with RUFY3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Singar1, a novel RUN domain-containing protein, suppresses formation of surplus axons for neuronal polarity. (PubMed id 17439943)1, 3 Mori T....Inagaki N. (2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T....Ohara O. (1998)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. Rab5(Q79L) interacts with the carboxyl terminus of RU FY3. (PubMed id 20376209)1 Yoshida H....Matsuda S. (2010)
    8. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PubMed id 17903297)4 Seshadri S....Wolf P.A. (2007)
    9. Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes. (PubMed id 17903304)4 Larson M.G....Levy D. (2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22902 HGNC: 30285 AceView: RIPX Ensembl:ENSG00000018189 euGenes: HUgn22902
    ECgene: RUFY3 H-InvDB: RUFY3

    (According to HUGE)
    About This Section
    HUGE: KIAA0871

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RUFY3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RUFY3 gene:
    Search GeneIP for patents involving RUFY3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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