RUFY2 Gene
protein-coding GIFtS: 48
GCID: GC10M070100
|
|
RUN and FYVE domain containing 2
| |
Aliases
for RUFY2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RUN And FYVE Domain Containing 21 2 | | FLJ100631 | | RABIP4R1 2 3 | | Antigen MU-RMS-40.172 | | ZFYVE131 2 | | RUN And FYVE Domain-Containing 22 | | KIAA15371 3 | | RUN And FYVE Domain-Containing Protein 22 | | Rab4-Interacting Protein Related2 3 | | Run- And FYVE-Domain Containing Protein2 |
Export aliases for RUFY2 gene to outside databasesPrevious GC identifers: GC10M069186 GC10M069993 GC10M069445 GC10M069770 GC10M064103 |
Summaries
for RUFY2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RUFY2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RUFY2 gene promoter:
CHOP-10 SRY Elk-1 NCX/Ncx C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for RUFY2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RUFY2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q21.3 Ensembl cytogenetic band: 10q21.3 HGNC cytogenetic band: 10q22.2RUFY2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M070100: view genomic region
(about GC identifiers)
Start:
|
70,100,864 bp from pter |
End:
|
70,167,051 bp from pter |
Size:
|
66,188 bases |
Orientation:
|
minus strand |
|
Proteins
for RUFY2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RUFY2_HUMAN, Q8WXA3 (See
protein sequence)Recommended Name: RUN and FYVE domain-containing protein 2 Size: 655 amino acids; 75055 Da
Subunit: Interacts with BMX
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=CAI17232.1; Type=Erroneous gene model prediction;
Secondary accessions: B3KXB2 Q5TC48 Q8IW33 Q96P51 Q9P1Z1Alternative splicing: 4 isoforms: Q8WXA3-1 Q8WXA3-2 Q8WXA3-3 Q8WXA3-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RUFY2: NX_Q8WXA3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WXA3
RUFY2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001035882.1 NP_060457.4
ENSEMBL proteins: ENSP00000433197 ENSP00000265865 ENSP00000341727 ENSP00000373420 ENSP00000382151 ENSP00000404986
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
RUFY2 for ontologies About GeneDecksing
RUFY2 Antibody Products:
Assay Products for RUFY2: |
Protein
Domains /
Families
for RUFY2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RUFY2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WXA3ProtoNet protein and cluster: Q8WXA3 1 Blocks protein family: IPB000306 Zn-finger
UniProtKB/Swiss-Prot: RUFY2_HUMAN, Q8WXA3Similarity: Contains 1 FYVE-type zinc fingerSimilarity: Contains 1 RUN domain |
Function
for RUFY2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RUFY2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RUFY2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): RUFY2 (NM_001042417) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RUFY2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUFY2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUFY2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0046872 | metal ion binding |
IEA | -- |
RUFY2 for ontologies About GeneDecksing
|
Pathways & Interactions
for RUFY2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RUFY2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/11 Interacting proteins for RUFY2 (Q8WXA32, 3 ENSP000003734204) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
|
Drugs & Compounds
for RUFY2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RUFY2
Search CenterWatch for drugs/clinical trials and news about RUFY2
|
Transcripts
for RUFY2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RUFY2 gene (2 alternative transcripts): NM_001042417.1 NM_017987.4 Unigene Cluster for RUFY2: RUN and FYVE domain containing 2 Hs.653144 [show with all ESTs]Unigene Representative Sequence: NM_01798712 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000466493(uc001jnz.1) ENST00000463210 ENST00000484083 ENST00000466187
ENST00000265865 ENST00000473398 ENST00000491118 ENST00000472394 ENST00000342616(uc001joe.1)
ENST00000388768(uc001joa.3 uc001job.3) ENST00000399200(uc001joc.3 uc010qiw.2 uc001jod.1 uc009xpv.1)
ENST00000454950
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RUFY2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RUFY2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RUFY2 (NM_001042417) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RUFY2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUFY2 |
Additional cDNA sequence: AB040970.1 AF411980.1 AF461266.1 AK055646.1 AK091629.1 AK294211.1 AY528716.1 BC020659.2 BC041092.1 BC062660.1 14 DOTS entries: DT.95263919 DT.100678426 DT.409243 DT.92419375 DT.95155659 DT.99942629 DT.97838276 DT.92008348 DT.95230056 DT.40113994 DT.40198251 DT.75109463 DT.75180673 DT.92424344 24/87 AceView cDNA sequences (see all 87): BQ723438 BC062660 BC041092 AF461266 AB040970 AF411980 AW337129 AI221958 AA251609 CA422079 CB995997 NM_017987 BQ776460 BG707400 AU117462 AK055646 AK127019 BG681628 BQ776772 AL713231 BC020659 BP353964 BM998747 CA396240
GeneLoc Exon Structure
|
Expression
for RUFY2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RUFY2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCCAGGGA
About this image
See RUFY2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RUFY2
SOURCE GeneReport for Unigene cluster: Hs.653144
UniProtKB/Swiss-Prot: RUFY2_HUMAN, Q8WXA3Tissue specificity: Expressed in brain, lung and testis
SABiosciences Custom PCR Arrays for RUFY2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RUFY2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RUFY2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RUFY2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RUFY2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUFY2 |
Orthologs
for RUFY2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RUFY2 gene from 4/21 species (see all 21) About this table
ENSEMBL Gene Tree for RUFY2 (if available)
TreeFam Gene Tree for RUFY2 (if available) |
Paralogs
for RUFY2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RUFY2 gene
- RUNDC3A2 RUNDC3B2 RUFY32 RUFY12
3 SIMAP similar genes for RUFY2 using alignment to 6 protein entries: RUFY2_HUMAN (see all proteins):RUFY3 RUFY1 RUNDC3A
RUFY2 for paralogs About GeneDecksing
|
Genomic Variants
for RUFY2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RUFY2 (70100864 - 70167051 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RUFY2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RUFY2 |
|
Disorders
/ Diseases
for RUFY2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RUFY2 for disorders About GeneDecksing
OMIM gene information: 610328
OMIM disorders: --
2  diseases for RUFY2: About MalaCardsalzheimer's disease malaria
Human Genome Epidemiology (HuGE) Navigator: RUFY2 (1 document)
Export disorders for RUFY2 gene to outside databases
|
Publications
for RUFY2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RUFY2 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with RUFY2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Interaction between tyrosine kinase Etk and a RUN-domain and FYVE- domain containing protein RUFY1. A possible role of Etk in regulation of vesicle trafficking. (PubMed id 11877430)1, 2, 3 Yang J.... Qiu Y. (2002)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
|
External Searches for RUFY2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RUFY2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RUFY2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing RUFY2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RUFY2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RUFY2 gene:
Search GeneIP for patents involving RUFY2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RUFY2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RUFY2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RUFY2 | | | OriGene Protein Over-expression Lysate for RUFY2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for RUFY2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RUFY2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RUFY2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RUFY2 | | OriGene Custom Protein Services for RUFY2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RUFY2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RUFY2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RUFY2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RUFY2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RUFY2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RUFY2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for RUFY2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | RUFY2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUFY2 |
|  |  |  | | | | ThermoFisher Antibodies for RUFY2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUFY2 |
|
|
|
|
