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RUFY2 Gene

protein-coding   GIFtS: 52
GCID: GC10M070100

RUN And FYVE Domain Containing 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RUN And FYVE Domain Containing 21 2     Antigen MU-RMS-40.172
Rab4-Interacting Protein Related2 3     RUN And FYVE Domain-Containing 22
RABIP4R2 3     RUN And FYVE Domain-Containing Protein 22
KIAA15373 5     Run- And FYVE-Domain Containing Protein2
ZFYVE132     

External Ids:    HGNC: 197611   Entrez Gene: 556802   Ensembl: ENSG000002041307   OMIM: 6103285   UniProtKB: Q8WXA33   

Export aliases for RUFY2 gene to outside databases

Previous GC identifers: GC10M069186 GC10M069993 GC10M069445 GC10M069770 GC10M064103


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RUFY2 Gene:
RUFY2 (RUN and FYVE domain containing 2) is a protein-coding gene. Diseases associated with RUFY2 include alzheimer's disease. An important paralog of this gene is RUNDC3A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RUFY2 gene promoter:
         CHOP-10   SRY   Elk-1   NCX/Ncx   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRUFY2 promoter sequence
   Search Chromatin IP Primers for RUFY2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RUFY2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.3   Ensembl cytogenetic band:  10q21.3   HGNC cytogenetic band: 10q22.2

RUFY2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RUFY2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M070100:  view genomic region     (about GC identifiers)

Start:
70,100,864 bp from pter      End:
70,167,051 bp from pter
Size:
66,188 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RUFY2_HUMAN, Q8WXA3 (See protein sequence)
Recommended Name: RUN and FYVE domain-containing protein 2  
Size: 655 amino acids; 75055 Da
Subunit: Interacts with BMX
Sequence caution: Sequence=CAI17232.1; Type=Erroneous gene model prediction;
Secondary accessions: B3KXB2 Q5TC48 Q8IW33 Q96P51 Q9P1Z1
Alternative splicing: 4 isoforms:  Q8WXA3-1   Q8WXA3-2   Q8WXA3-3   Q8WXA3-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RUFY2: NX_Q8WXA3

Explore proteomics data for RUFY2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RUFY2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001035882.1  NP_001265154.1  NP_060457.4  

    ENSEMBL proteins: 
     ENSP00000433197   ENSP00000474574   ENSP00000473462   ENSP00000265865   ENSP00000341727  
     ENSP00000373420   ENSP00000382151   ENSP00000404986  

    RUFY2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for RUFY2

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    Abcam antibodies for RUFY2
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    ThermoFisher Antibodies for RUFY2
    Search LSBio for Antibodies for RUFY2

    RUFY2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for RUFY2
    Cloud-Clone Corp. CLIAs for RUFY2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFYVE: Zinc fingers, FYVE domain containing

    5 InterPro protein domains:
     IPR000306 Znf_FYVE
     IPR017455 Znf_FYVE-rel
     IPR013083 Znf_RING/FYVE/PHD
     IPR004012 Run
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q8WXA3

    ProtoNet protein and cluster: Q8WXA3

    1 Blocks protein domain: IPB000306 Zn-finger

    UniProtKB/Swiss-Prot: RUFY2_HUMAN, Q8WXA3
    Similarity: Contains 1 FYVE-type zinc finger
    Similarity: Contains 1 RUN domain


    RUFY2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    RUFY2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RUFY2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RUFY2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RUFY2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RUFY2

    miRNA
    Products:
        
    miRTarBase miRNAs that target RUFY2:
    hsa-mir-335-5p (MIRT017147), hsa-mir-425-5p (MIRT039337), hsa-mir-20a-5p (MIRT050604), hsa-mir-196a-5p (MIRT048254)

    Block miRNA regulation of human, mouse, rat RUFY2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RUFY2 (see all 40):
    hsa-let-7d hsa-miR-106a hsa-miR-578 hsa-miR-218 hsa-miR-519a hsa-let-7g hsa-let-7a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidRUFY2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RUFY2
    Predesigned siRNA for gene silencing in human, mouse, rat RUFY2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): RUFY2 (NM_001042417)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUFY2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for RUFY2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUFY2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RUFY2_HUMAN, Q8WXA3: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    mitochondrion2
    endosome1
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    RUFY2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RUFY2
    Interactions:

        Search GeneGlobe Interaction Network for RUFY2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for RUFY2 (Q8WXA32, 3 ENSP000003734204) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DUSP23Q9BVJ72, 3MINT-8254732 I2D: score=2 
    SF3B3Q153932, 3, ENSP000003057904MINT-8270308 I2D: score=2 STRING: ENSP00000305790
    BMXP518133, ENSP000003087744I2D: score=2 STRING: ENSP00000308774
    EPHA3P293203, ENSP000003374514I2D: score=1 STRING: ENSP00000337451
    CHIAENSP000003418284STRING: ENSP00000341828
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RUFY2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RUFY2 gene (3 alternative transcripts): 
    NM_001042417.1  NM_001278225.1  NM_017987.4  

    Unigene Cluster for RUFY2:

    RUN and FYVE domain containing 2
    Hs.653144  [show with all ESTs]
    Unigene Representative Sequence: NM_017987
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466493(uc001jnz.1) ENST00000484083 ENST00000463210 ENST00000466187
    ENST00000602465 ENST00000265865 ENST00000473398 ENST00000491118 ENST00000472394
    ENST00000342616(uc001joe.1) ENST00000388768(uc001joa.3 uc001job.3)
    ENST00000399200(uc001joc.3 uc010qiw.2 uc001jod.1 uc009xpv.1)
    ENST00000454950
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RUFY2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RUFY2 (see all 40):
    hsa-let-7d hsa-miR-106a hsa-miR-578 hsa-miR-218 hsa-miR-519a hsa-let-7g hsa-let-7a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidRUFY2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RUFY2
    Predesigned siRNA for gene silencing in human, mouse, rat RUFY2
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    GenScript: all cDNA clones in your preferred vector (see all 2): RUFY2 (NM_001042417)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RUFY2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUFY2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RUFY2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RUFY2
      QuantiTect SYBR Green Assays in human, mouse, rat RUFY2
      QuantiFast Probe-based Assays in human, mouse, rat RUFY2

    Additional mRNA sequence: 

    AB040970.1 AF411980.1 AF461266.1 AK055646.1 AK091629.1 AK294211.1 AY528716.1 BC020659.2 
    BC041092.1 BC062660.1 

    14 DOTS entries:

    DT.95263919  DT.100678426  DT.92419375  DT.409243  DT.95155659  DT.99942629  DT.97838276  DT.92008348 
    DT.95230056  DT.40113994  DT.40198251  DT.75109463  DT.75180673  DT.92424344 

    Selected AceView cDNA sequences (see all 87):

    NM_017987 CA422079 AB040970 AW337129 AF411980 BQ723438 AA251609 CB995997 
    BC062660 BQ776460 AI221958 AF461266 BC041092 BX101911 AK127019 BI546055 
    T80342 AK055646 BX486877 AK091629 CA396240 BG681628 BQ006812 BG164444 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RUFY2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCCAGGGA
    RUFY2 Expression
    About this image


    RUFY2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
    RUFY2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RUFY2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.653144

    UniProtKB/Swiss-Prot: RUFY2_HUMAN, Q8WXA3
    Tissue specificity: Expressed in brain, lung and testis

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUFY2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RUFY2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rufy21 , 5 RUN and FYVE domain-containing 21, 5 86.96(n)1
    94.88(a)1
      10 (32.51 cM)5
    704321  NM_027425.31  NP_081701.21 
     629802235 
    chicken
    (Gallus gallus)
    Aves RUFY21 RUN and FYVE domain containing 2 81.68(n)
    89.6(a)
      423687  XM_421568.4  XP_421568.2 
    lizard
    (Anolis carolinensis)
    Reptilia RUFY26
    RUN and FYVE domain containing 2
    81(a)
    1 ↔ 1
    GL343215.1(1526247-1551938)
    zebrafish
    (Danio rerio)
    Actinopterygii rufy21 RUN and FYVE domain containing 2 71.31(n)
    78.94(a)
      569096  NM_001244919.1  NP_001231848.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG310641 CG31064 51.27(n)
    46.19(a)
      43277  NM_170324.2  NP_733203.1 


    ENSEMBL Gene Tree for RUFY2 (if available)
    TreeFam Gene Tree for RUFY2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RUFY2 gene
    RUNDC3A2  RUFY32  RUNDC3B2  RUFY12  
    3 SIMAP similar genes for RUFY2 using alignment to 7 protein entries:     RUFY2_HUMAN (see all proteins):
    RUFY3    RUFY1    RUNDC3A

    RUFY2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RUFY2 (see all 1324)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs172974391,2
    C,F,H--70103461(+) ATCACG/AAAATA 1 -- ut3121Minor allele frequency- A:0.10NA NS EA WA 2482
    rs1848425451,2
    --70103477(+) TGTTAA/GAAGTC 1 -- ut310--------
    rs1904177441,2
    C--70103497(+) AAAAAC/TCCAAA 1 -- ut310--------
    rs1484363431,2
    C--70103501(+) TCCAA-/AGTT  
            
    AGTTA
    1 -- ut310--------
    rs1482160391,2
    --70103508(+) GTTAGA/TATAGT 1 -- ut310--------
    rs1397899201,2
    C--70103564(+) CTGCC-/TTAAAA 1 -- ut310--------
    rs11627551,2
    C,F,A,H--70103566(-) TTTTTA/TAGGCA 1 -- ut315Minor allele frequency- T:0.17NA WA 12
    rs348117011,2
    F--70103590(+) AAAAAG/AGCAAG 1 -- ut311Minor allele frequency- A:0.50NA 4
    rs11627541,2
    C,F,H--70103597(-) TGACTT/GACTTG 1 -- ut3116Minor allele frequency- G:0.01MN NS EA NA WA CSA 957
    rs1412182571,2
    C--70103616(+) ACATGA/GGTTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RUFY2 (70100864 - 70167051 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RUFY2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670140CNV Deletion23128226
    nsv6988CNV Insertion18451855
    nsv895691CNV Loss21882294
    nsv895690CNV Loss21882294
    nsv895692CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RUFY2
    DNA2.0 Custom Variant and Variant Library Synthesis for RUFY2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610328    OMIM disorders: --

    1 disease for RUFY2:    
    About MalaCards
    alzheimer's disease


    RUFY2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RUFY2
    Human Genome Epidemiology (HuGE) Navigator: RUFY2 (1 document)

    Export disorders for RUFY2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RUFY2 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with RUFY2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction between tyrosine kinase Etk and a RUN-domain and FYVE- domain containing protein RUFY1. A possible role of Etk in regulation of vesicle trafficking. (PubMed id 11877430)1, 2, 3 Yang J.... Qiu Y. (J. Biol. Chem. 2002)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    5. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    6. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55680 HGNC: 19761 AceView: RUFY2 Ensembl:ENSG00000204130 euGenes: HUgn55680
    ECgene: RUFY2 H-InvDB: RUFY2

    (According to HUGE)
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    HUGE: KIAA1537

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RUFY2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RUFY2 gene:
    Search GeneIP for patents involving RUFY2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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