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Aliases for RUFY2 Gene

Aliases for RUFY2 Gene

  • RUN And FYVE Domain Containing 2 2 3
  • Rab4-Interacting Protein Related 3 4
  • KIAA1537 4 6
  • RABIP4R 3 4
  • RUN And FYVE Domain-Containing Protein 2 3
  • Run- And FYVE-Domain Containing Protein 3
  • RUN And FYVE Domain-Containing 2 3
  • Antigen MU-RMS-40.17 3
  • ZFYVE13 3

External Ids for RUFY2 Gene

Summaries for RUFY2 Gene

GeneCards Summary for RUFY2 Gene

RUFY2 (RUN And FYVE Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is RUNDC3B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RUFY2 Gene

Genomics for RUFY2 Gene

Genomic Location for RUFY2 Gene

Start:
68,341,107 bp from pter
End:
68,407,294 bp from pter
Size:
66,188 bases
Orientation:
Minus strand

Genomic View for RUFY2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RUFY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RUFY2 Gene

Regulatory Elements for RUFY2 Gene

Proteins for RUFY2 Gene

  • Protein details for RUFY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXA3-RUFY2_HUMAN
    Recommended name:
    RUN and FYVE domain-containing protein 2
    Protein Accession:
    Q8WXA3
    Secondary Accessions:
    • B3KXB2
    • B4DFR0
    • Q5TC48
    • Q8IW33
    • Q96P51
    • Q9P1Z1

    Protein attributes for RUFY2 Gene

    Size:
    655 amino acids
    Molecular mass:
    75055 Da
    Quaternary structure:
    • Interacts with BMX.
    SequenceCaution:
    • Sequence=CAI17232.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for RUFY2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RUFY2 Gene

Proteomics data for RUFY2 Gene at MOPED

Post-translational modifications for RUFY2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RUFY2 Gene

Domains for RUFY2 Gene

Gene Families for RUFY2 Gene

HGNC:
  • ZFYVE :Zinc fingers, FYVE domain containing

Protein Domains for RUFY2 Gene

UniProtKB/Swiss-Prot:

RUFY2_HUMAN
Domain:
  • Contains 1 RUN domain.:
    • Q8WXA3
Similarity:
  • Contains 1 FYVE-type zinc finger.:
    • Q8WXA3
genes like me logo Genes that share domains with RUFY2: view

Function for RUFY2 Gene

Gene Ontology (GO) - Molecular Function for RUFY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RUFY2: view

miRNA for RUFY2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RUFY2 Gene

Localization for RUFY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RUFY2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RUFY2 Gene COMPARTMENTS Subcellular localization image for RUFY2 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 2
endosome 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RUFY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with RUFY2: view

Pathways for RUFY2 Gene

SuperPathways for RUFY2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RUFY2 Gene

None

No data available for Pathways by source for RUFY2 Gene

Transcripts for RUFY2 Gene

Unigene Clusters for RUFY2 Gene

RUN and FYVE domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RUFY2 Gene

No ASD Table

Relevant External Links for RUFY2 Gene

GeneLoc Exon Structure for
RUFY2
ECgene alternative splicing isoforms for
RUFY2

Expression for RUFY2 Gene

mRNA expression in normal human tissues for RUFY2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RUFY2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RUFY2 Gene

SOURCE GeneReport for Unigene cluster for RUFY2 Gene Hs.653144

mRNA Expression by UniProt/SwissProt for RUFY2 Gene

Q8WXA3-RUFY2_HUMAN
Tissue specificity: Expressed in brain, lung and testis.
genes like me logo Genes that share expressions with RUFY2: view

Orthologs for RUFY2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RUFY2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RUFY2 36
  • 99.74 (n)
  • 100 (a)
RUFY2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RUFY2 36
  • 94.22 (n)
  • 96.86 (a)
RUFY2 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RUFY2 36
  • 93.74 (n)
  • 97.09 (a)
RUFY2 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rufy2 36
  • 86.96 (n)
  • 94.88 (a)
Rufy2 16
Rufy2 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RUFY2 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 99 (a)
OneToMany
-- 37
  • 91 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rufy2 36
  • 88.5 (n)
  • 95.87 (a)
chicken
(Gallus gallus)
Aves RUFY2 36
  • 81.68 (n)
  • 89.6 (a)
RUFY2 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RUFY2 37
  • 81 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9356 36
zebrafish
(Danio rerio)
Actinopterygii rufy2 36
  • 71.31 (n)
  • 78.94 (a)
rufy2 37
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003431 36
  • 52.76 (n)
  • 50.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31064 36
  • 51.27 (n)
  • 46.19 (a)
CG31064 37
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 44 (a)
OneToMany
Species with no ortholog for RUFY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RUFY2 Gene

ENSEMBL:
Gene Tree for RUFY2 (if available)
TreeFam:
Gene Tree for RUFY2 (if available)

Paralogs for RUFY2 Gene

Paralogs for RUFY2 Gene

Selected SIMAP similar genes for RUFY2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RUFY2: view

Variants for RUFY2 Gene

Sequence variations from dbSNP and Humsavar for RUFY2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs956124 -- 68,385,743(-) ACCTA(A/T)ATTTA intron-variant
rs1133227 -- 68,362,233(-) ctccc(A/C)ccttg intron-variant
rs1162753 -- 68,345,803(+) GAGCA(A/G)TGCAT reference, synonymous-codon, nc-transcript-variant, downstream-variant-500B
rs1162754 -- 68,343,840(-) TGACT(G/T)ACTTG utr-variant-3-prime, intron-variant
rs1162755 -- 68,343,809(-) TTTTT(A/T)AGGCA utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RUFY2 Gene

Variant ID Type Subtype PubMed ID
nsv895690 CNV Loss 21882294
nsv895691 CNV Loss 21882294
nsv895692 CNV Loss 21882294
nsv6988 CNV Insertion 18451855
esv2670140 CNV Deletion 23128226

Relevant External Links for RUFY2 Gene

HapMap Linkage Disequilibrium report
RUFY2

Disorders for RUFY2 Gene

Relevant External Links for RUFY2

Genetic Association Database (GAD)
RUFY2
Human Genome Epidemiology (HuGE) Navigator
RUFY2
genes like me logo Genes that share disorders with RUFY2: view

No data available for UniProtKB/Swiss-Prot for RUFY2 Gene

Publications for RUFY2 Gene

  1. Interaction between tyrosine kinase Etk and a RUN-domain and FYVE- domain containing protein RUFY1. A possible role of Etk in regulation of vesicle trafficking. (PMID: 11877430) Yang J. … Qiu Y. (J. Biol. Chem. 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49

Products for RUFY2 Gene

Sources for RUFY2 Gene

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