Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RUFY1 Gene

protein-coding   GIFtS: 52
GCID: GC05P178977

RUN and FYVE domain containing 1

 Explore 1 disease affiliated with
RUFY1 via our new
 Human Malady Compendium 
Biological research products
for RUFY1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
RUN And FYVE Domain Containing 11 2     Zinc Finger FYVE Domain-Containing Protein 122 3
RABIP41 2 3     FYVE-Finger Protein EIP12 3
ZFYVE121 2 3     FLJ222511
La-Binding Protein 12 3     RUN And FYVE Domain-Containing Protein 12
Rab4-Interacting Protein2 3     

External Ids:    HGNC: 197601   Entrez Gene: 802302   Ensembl: ENSG000001767837   OMIM: 6103275   UniProtKB: Q96T513   

Export aliases for RUFY1 gene to outside databases

Previous GC identifers: GC00U990921 GC05P179802 GC05P179045 GC05P179090 GC05P178910 GC05P173702


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RUFY1:
This gene encodes a protein that contains a RUN domain and a FYVE-type zinc finger domain. The encoded protein binds to
phosphatidylinositol-3-phosphate (PI3P) and plays a role in early endosomal trafficking, tethering and fusion through
interactions with small GTPases including Rab4, Rab5 and Rab14. Alternatively spliced transcript variants encoding
multiple isoforms have been observed for this gene. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: RUFY1_HUMAN, Q96T51
Function: Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal
trafficking

Gene Wiki entry for RUFY1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RUFY1 gene promoter:
         ISGF-3   LHX3b/Lhx3b   LHX3a/Lhx3a   MyoD   AP-4   Pax-4a   Cdc5   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RUFY1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RUFY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

RUFY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RUFY1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P178977:  view genomic region     (about GC identifiers)

Start:
178,977,559 bp from pter      End:
179,037,027 bp from pter
Size:
59,469 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RUFY1_HUMAN, Q96T51 (See protein sequence)
Recommended Name: RUN and FYVE domain-containing protein 1  
Size: 708 amino acids; 79818 Da
Subunit: Interacts with BMX. May interact with SSB. Interacts with RAB4 and RAB5 that have been activated by
GTP-binding
Subcellular location: Cytoplasm. Early endosome membrane; Peripheral membrane protein
Sequence caution: Sequence=AAK50771.1; Type=Frameshift; Positions=47, 88; Sequence=BAB15276.1; Type=Erroneous
initiation;
2 PDB 3D structures from and Proteopedia for RUFY1:
2YQM (3D)        2YW8 (3D)    
Secondary accessions: Q59FF3 Q71S93 Q9H6I3
Alternative splicing: 3 isoforms:  Q96T51-1   Q96T51-2   Q96T51-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RUFY1: NX_Q96T51

Post-translational modifications:

  • Phosphorylation on Tyr-389 and/or Tyr-400 is required for interaction with BMX and endosomal targeting1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96T51

  • RUFY1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001035541.1  NP_001035542.1  NP_079434.3  

    ENSEMBL proteins: 
     ENSP00000325594   ENSP00000377094   ENSP00000425533   ENSP00000390025   ENSP00000377087  
     ENSP00000426701   ENSP00000426117   ENSP00000366200  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: RUFY1
    OriGene Protein Over-expression Lysate (see all 2): RUFY1
    OriGene Custom Protein Services for RUFY1 
    GenScript Custom Purified and Recombinant Proteins Services for RUFY1
    Novus Biologicals RUFY1 Proteins
    Novus Biologicals RUFY1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RUFY1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0031901early endosome membrane IEA--


    RUFY1 for ontologies           About GeneDecksing



    RUFY1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RUFY1 
    GenScript Custom Superior Antibodies Services for RUFY1
    Novus Biologicals RUFY1 Antibodies
    Search for Antibodies for RUFY1 at Abcam  
    Uscn Antibodies for RUFY1
    Search ThermoFisher Antibodies for RUFY1

    Assay Products for RUFY1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RUFY1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RUFY1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RUFY1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001841 Znf_RING
     IPR000306 Znf_FYVE
     IPR017455 Znf_FYVE-rel
     IPR013083 Znf_RING/FYVE/PHD
     IPR004012 Run

    Graphical View of Domain Structure for InterPro Entry Q96T51

    ProtoNet protein and cluster: Q96T51

    2 Blocks protein families:
    IPB000306 Zn-finger
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: RUFY1_HUMAN, Q96T51
    Domain: The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of
    early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially
    increased in acidic conditions
    Similarity: Contains 1 FYVE-type zinc finger
    Similarity: Contains 1 RUN domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: RUFY1_HUMAN, Q96T51
    Function: Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal
    trafficking

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 3): RUFY1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RUFY1
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate RUFY1:
    hsa-miR-485-5p hsa-miR-124 hsa-miR-548p hsa-miR-506 hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidRUFY1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RUFY1 (see all 7)
    OriGene shRNA RFP: RUFY1
    OriGene siRNA: RUFY1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RUFY1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RUFY1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RUFY1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RUFY1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): RUFY1 (NM_025158)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RUFY1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUFY1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RUFY1
    Search LifeMap BioReagents cell lines for RUFY1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUFY1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
    GO:0008289lipid binding IEA--
    GO:0008565protein transporter activity IEA--


    RUFY1 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Endocytosis
    Endocytosis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for RUFY1):
        Endocytosis


    RUFY1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RUFY1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for RUFY1 (Q96T511, 2, 3 ENSP000003770944) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HCKP086312, 3, ENSP000003650124MINT-7302799 I2D: score=1 STRING: ENSP00000365012
    EPHA3P293202, 3, ENSP000003374514MINT-8032251 MINT-8035980 I2D: score=2 STRING: ENSP00000337451
    RAB4AP203383, ENSP000003556514I2D: score=2 STRING: ENSP00000355651
    BMXP518133, ENSP000003087744I2D: score=3 STRING: ENSP00000308774
    PIAS2O759281, ENSP000003816484EBI-3941207,EBI-348555 STRING: ENSP00000381648
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0015031protein transport ----
    GO:0030100regulation of endocytosis IEA--


    RUFY1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RUFY1

    1 HMDB Compound for RUFY1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about RUFY1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RUFY1 gene (3 alternative transcripts): 
    NM_001040451.2  NM_001040452.2  NM_025158.4  

    Unigene Cluster for RUFY1:

    RUN and FYVE domain containing 1
    Hs.306769  [show with all ESTs]
    Unigene Representative Sequence: NM_001040451
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319449(uc003mka.1 uc003mkd.1) ENST00000393448 ENST00000502984
    ENST00000507569 ENST00000437570(uc003mkc.1) ENST00000393438(uc003mkb.1)
    ENST00000503514 ENST00000508609 ENST00000514238 ENST00000502434 ENST00000509797
    ENST00000502531 ENST00000503583 ENST00000508797 ENST00000377001

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 3): RUFY1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RUFY1
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate RUFY1:
    hsa-miR-485-5p hsa-miR-124 hsa-miR-548p hsa-miR-506 hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidRUFY1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RUFY1 (see all 7)
    OriGene shRNA RFP: RUFY1
    OriGene siRNA: RUFY1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RUFY1
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RUFY1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RUFY1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): RUFY1 (NM_025158)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RUFY1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUFY1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RUFY1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RUFY1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RUFY1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RUFY1

    Additional cDNA sequence: 

    AF312367.1 AF361055.2 AK025904.1 AK075021.1 AK093848.1 AK291926.1 BC016564.1 BC032571.1 

    13 DOTS entries:

    DT.99974200  DT.97770263  DT.100842241  DT.215543  DT.100025583  DT.97806798  DT.95163292  DT.120836253 
    DT.97843447  DT.101984049  DT.120836265  DT.40235337  DT.97762492 

    24/205 AceView cDNA sequences (see all 205):

    BF971204 AA813873 AI524194 BF969026 CF132098 AI652188 AA643270 CA848609 
    BQ777219 BX505539 BI870715 BI918275 BM908387 AW021971 AW957168 AL537236 
    AA369890 AW271726 AW575715 BE042875 BQ787920 BE742350 BI913227 AA768162 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RUFY1 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^
    SP1:                                                  -                                   -     -                                               -           -   
    SP2:              -     -     -     -                 -                                   -     -                                               -           -   
    SP3:                                                  -                                   -     -                                               -           -   
    SP4:              -     -     -     -                 -                                         -                                               -               
    SP5:                                                                                                                                            -           -   

    ExUns: 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b
    SP1:        -     -     -                     
    SP2:        -     -     -                     
    SP3:        -     -     -                     
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for RUFY1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RUFY1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCTTGTGAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See RUFY1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RUFY1

    SOURCE GeneReport for Unigene cluster: Hs.306769

    UniProtKB/Swiss-Prot: RUFY1_HUMAN, Q96T51
    Tissue specificity: Broadly expressed, with highest levels in lung, testis, kidney and brain

        SABiosciences Custom PCR Arrays for RUFY1
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RUFY1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RUFY1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RUFY1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RUFY1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUFY1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RUFY1 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rufy11 , 5 RUN and FYVE domain containing 11, 5 87.72(n)1
    92.77(a)1
      11 (30.57 cM)5
    2167241  NM_172557.21  NP_766145.11 
     503892865 
    chicken
    (Gallus gallus)
    Aves RUFY11 RUN and FYVE domain containing 1 76.16(n)
    80.53(a)
      426519  XM_003642064.1  XP_003642112.1 
    lizard
    (Anolis carolinensis)
    Reptilia RUFY16
    --
    80(a)
    1 ↔ 1
    2(140431243-140455882)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.168052 Transcribed sequence with weak similarity to protein more 77.05(n)    142018949 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003300771 RUN and FYVE domain-containing protein 1-like 64.42(n)
    64.37(a)
      100330077  XM_002667315.2  XP_002667361.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG310646
    --
    24(a)
    1 → many
    3R(23055227-23064803)


    ENSEMBL Gene Tree for RUFY1 (if available)
    TreeFam Gene Tree for RUFY1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RUFY1 gene
    RUFY22  RUNDC3A2  RUNDC3B2  RUFY32  
    18/27 SIMAP similar genes for RUFY1 using alignment to 5 protein entries:     RUFY1_HUMAN (see all proteins) (see all similar genes):
    TMEM14B    TMEM44    C4orf22    PLA2G6    RUFY3    APOD
    NF2    AURA2    HECW1    LINC00596    ZNF212    ZNF564
    RUFY2    HMGA2    FAM175A    SPATS2L    LYRM4    SHANK2

    RUFY1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1225 NCBI SNPs in RUFY1 are shown (see all 1225    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2013722021,2
    --178975600(+) GAGGC-/GGGGGG 1 -- us2k10--------
    rs131835211,2
    C,A,--178975606(+) GGGGGA/GATCAC 1 -- us2k15Minor allele frequency- G:0.37NA WA EA 362
    rs1379368411,2
    C,--178975829(+) CTCAA-/AAAC  
            
    AAACA
    1 -- us2k10--------
    rs577007321,2
    C--178975831(+) AACAA-/ACAA  
            
    GACCA
    1 -- us2k11Minor allele frequency- ACAA:0.00NA 2
    rs68961121,2
    C,--178975899(+) GAGGCT/CGAGGC 1 -- us2k12Minor allele frequency- C:0.25NA 4
    rs1923280981,2
    --178975918(+) CACGAA/GGTCAG 1 -- us2k10--------
    rs1846606251,2
    --178975949(+) TAACAC/GGGTGA 1 -- us2k10--------
    rs709977011,2
    C--178975978(+) AAAAAA/-TTAGC 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1901627251,2
    --178976016(+) GGGCAC/TCTGTA 1 -- us2k10--------
    rs47008351,2
    C,F,A,--178976313(+) CCAAGG/ACAGGT 1 -- us2k110Minor allele frequency- A:0.45NA WA CSA EA 371

    HapMap Linkage Disequilibrium report for RUFY1 (178977559 - 179037027 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for RUFY1
         1 CNV: 3590
         2 Inversions: 0596 37259

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RUFY1
    DNA2.0 Custom Variant and Variant Library Synthesis for RUFY1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RUFY1 for disorders           About GeneDecksing

    OMIM gene information: 610327    OMIM disorders: --

    1 disease for RUFY1:    About MalaCards
    malaria


    Export disorders for RUFY1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RUFY1 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with RUFY1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction between tyrosine kinase Etk and a RUN-domain and FYVE- domain containing protein RUFY1. A possible role of Etk in regulation of vesicle trafficking. (PubMed id 11877430)1, 2, 3 Yang J.... Qiu Y. (2002)
    2. Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes. (PubMed id 14617813)1, 2 Fouraux M.A.... Pruijn G.J.M. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (2012)
    8. Genome-wide association analysis of eating disorder-re lated symptoms, behaviors, and personality traits. (PubMed id 22911880)1 Boraska V....Zeggini E. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80230 HGNC: 19760 AceView: RUFY1 Ensembl:ENSG00000176783 euGenes: HUgn80230
    ECgene: RUFY1 Kegg: 80230 H-InvDB: RUFY1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RUFY1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RUFY1 gene:
    Search GeneIP for patents involving RUFY1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for RUFY1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RUFY1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RUFY1  
     OriGene Protein Over-expression Lysate for RUFY1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for RUFY1   OriGene 3'-UTR Clone for RUFY1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RUFY1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RUFY1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for RUFY1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RUFY1   OriGene Custom Protein Services for RUFY1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RUFY1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RUFY1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RUFY1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RUFY1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RUFY1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RUFY1
     GenScript Custom Purified and Recombinant Proteins Services for RUFY1 GenScript cDNA clones with any tag delivered in your preferred vector for RUFY1
     GenScript Custom Assay Services for RUFY1 GenScript Custom Superior Antibodies Services for RUFY1
     GenScript Custom overexpressing Cell Line Services for RUFY1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RUFY1 promoter
     Search Chromatin IP Primers for RUFY1
     RT2 qPCR Primer Assay in human, mouse, rat RUFY1
     GNC Network for RUFY1
     SABiosciences Custom PCR Arrays for RUFY1
     Search Tocris compounds for RUFY1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RUFY1 antibodies
     RUFY1 proteins
     RUFY1 lysates
     Search for Antibodies for RUFY1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for RUFY1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     RUFY1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for RUFY1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUFY1
     SwitchGear 3'UTR luciferase reporter plasmids for RUFY1
     Browse SwitchGear Promoter luciferase reporter plasmids for RUFY1
     Search ThermoFisher Antibodies for RUFY1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RUFY1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RUFY1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4