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RUFY1 Gene

protein-coding   GIFtS: 55
GCID: GC05P178977

RUN And FYVE Domain Containing 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RUN And FYVE Domain Containing 11 2     RABIP42 3
La-Binding Protein 12 3     ZFYVE122 3
Rab4-Interacting Protein2 3     FYVE-Finger Protein EIP12 3
Zinc Finger FYVE Domain-Containing Protein 122 3     RUN And FYVE Domain-Containing Protein 12

External Ids:    HGNC: 197601   Entrez Gene: 802302   Ensembl: ENSG000001767837   OMIM: 6103275   UniProtKB: Q96T513   

Export aliases for RUFY1 gene to outside databases

Previous GC identifers: GC00U990921 GC05P179802 GC05P179045 GC05P179090 GC05P178910 GC05P173702


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RUFY1 Gene:
This gene encodes a protein that contains a RUN domain and a FYVE-type zinc finger domain. The encoded protein
binds to phosphatidylinositol-3-phosphate (PI3P) and plays a role in early endosomal trafficking, tethering and
fusion through interactions with small GTPases including Rab4, Rab5 and Rab14. Alternatively spliced transcript
variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for RUFY1 Gene:
RUFY1 (RUN and FYVE domain containing 1) is a protein-coding gene. GO annotations related to this gene include protein transporter activity and lipid binding. An important paralog of this gene is RUNDC3A.

UniProtKB/Swiss-Prot: RUFY1_HUMAN, Q96T51
Function: Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early
endosomal trafficking

Gene Wiki entry for RUFY1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RUFY1 gene promoter:
         ISGF-3   LHX3b/Lhx3b   LHX3a/Lhx3a   MyoD   AP-4   Pax-4a   Cdc5   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for RUFY1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RUFY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

RUFY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RUFY1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P178977:  view genomic region     (about GC identifiers)

Start:
178,977,559 bp from pter      End:
179,037,027 bp from pter
Size:
59,469 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RUFY1_HUMAN, Q96T51 (See protein sequence)
Recommended Name: RUN and FYVE domain-containing protein 1  
Size: 708 amino acids; 79818 Da
Subunit: Interacts with BMX. May interact with SSB. Interacts with RAB4 and RAB5 that have been activated by
GTP-binding
Sequence caution: Sequence=AAK50771.1; Type=Frameshift; Positions=47, 88; Sequence=BAB15276.1; Type=Erroneous
initiation;
2 PDB 3D structures from and Proteopedia for RUFY1:
2YQM (3D)        2YW8 (3D)    
Secondary accessions: Q59FF3 Q71S93 Q9H6I3
Alternative splicing: 3 isoforms:  Q96T51-1   Q96T51-2   Q96T51-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RUFY1: NX_Q96T51

Explore proteomics data for RUFY1 at MOPED

Post-translational modifications: 

  • Phosphorylation on Tyr-389 and/or Tyr-400 is required for interaction with BMX and endosomal targeting1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RUFY1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001035541.1  NP_001035542.1  NP_079434.3  

    ENSEMBL proteins: 
     ENSP00000325594   ENSP00000377094   ENSP00000425533   ENSP00000390025   ENSP00000377087  
     ENSP00000426701   ENSP00000426117   ENSP00000366200  

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    Cloud-Clone Corp. Proteins for RUFY1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFYVE: Zinc fingers, FYVE domain containing

    Selected InterPro protein domains (see all 6):
     IPR001841 Znf_RING
     IPR000306 Znf_FYVE
     IPR017455 Znf_FYVE-rel
     IPR013083 Znf_RING/FYVE/PHD
     IPR004012 Run

    Graphical View of Domain Structure for InterPro Entry Q96T51

    ProtoNet protein and cluster: Q96T51

    2 Blocks protein domains:
    IPB000306 Zn-finger
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: RUFY1_HUMAN, Q96T51
    Domain: The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes
    of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is
    substantially increased in acidic conditions
    Similarity: Contains 1 FYVE-type zinc finger
    Similarity: Contains 1 RUN domain


    Find genes that share domains with RUFY1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RUFY1_HUMAN, Q96T51
    Function: Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early
    endosomal trafficking

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
    GO:0008289lipid binding IEA--
    GO:0008565protein transporter activity IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with RUFY1           About GenesLikeMe


    Animal Models:
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    hsa-miR-485-5p hsa-miR-124 hsa-miR-548p hsa-miR-506 hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidRUFY1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RUFY1_HUMAN, Q96T51: Cytoplasm. Early endosome membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol3
    nucleus2
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0031901early endosome membrane IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with RUFY1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RUFY1 About    
    See pathways by source

    SuperPathContained pathways About
    1Endocytosis
    Endocytosis


    Find genes that share SuperPaths with RUFY1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for RUFY1):
        Endocytosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RUFY1
    Interactions:

        GeneGlobe Interaction Network for RUFY1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for RUFY1 (Q96T511, 2, 3 ENSP000003770944) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HCKP086312, 3, ENSP000003650124MINT-7302799 I2D: score=1 STRING: ENSP00000365012
    EPHA3P293202, 3, ENSP000003374514MINT-8032251 MINT-8035980 I2D: score=2 STRING: ENSP00000337451
    RAB4AP203383, ENSP000003556514I2D: score=2 STRING: ENSP00000355651
    BMXP518133, ENSP000003087744I2D: score=3 STRING: ENSP00000308774
    PIAS2O759281, ENSP000003816484EBI-3941207,EBI-348555 STRING: ENSP00000381648
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    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0015031protein transport ----
    GO:0030100regulation of endocytosis IEA--

    Find genes that share ontologies with RUFY1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RUFY1

    1 HMDB Compound for RUFY1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RUFY1 gene (3 alternative transcripts): 
    NM_001040451.2  NM_001040452.2  NM_025158.4  

    Unigene Cluster for RUFY1:

    RUN and FYVE domain containing 1
    Hs.306769  [show with all ESTs]
    Unigene Representative Sequence: NM_001040451
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319449(uc003mka.1 uc003mkd.1) ENST00000393448 ENST00000502984
    ENST00000507569 ENST00000437570(uc003mkc.1) ENST00000393438(uc003mkb.1)
    ENST00000503514 ENST00000508609 ENST00000514238 ENST00000502434 ENST00000509797
    ENST00000502531 ENST00000503583 ENST00000508797 ENST00000377001
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate RUFY1:
    hsa-miR-485-5p hsa-miR-124 hsa-miR-548p hsa-miR-506 hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidRUFY1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): RUFY1 (NM_025158)
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    Primer
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    Additional mRNA sequence: 

    AF312367.1 AF361055.2 AK025904.1 AK075021.1 AK093848.1 AK291926.1 BC016564.1 BC032571.1 

    13 DOTS entries:

    DT.99974200  DT.97770263  DT.215543  DT.100842241  DT.100025583  DT.97806798  DT.95163292  DT.120836253 
    DT.97843447  DT.101984049  DT.120836265  DT.40235337  DT.97762492 

    Selected AceView cDNA sequences (see all 205):

    BM740867 BC032571 BU526633 BM908387 AA749083 BF971204 BI918275 CD672583 
    AL537236 BP340293 AW021971 AW957168 AW271726 AA369890 AW575715 BE042875 
    BE742350 BQ787920 BI913227 AA768162 AI623209 CA848320 AI524194 AA813873 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RUFY1 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^
    SP1:                                                  -                                   -     -                                               -           -   
    SP2:              -     -     -     -                 -                                   -     -                                               -           -   
    SP3:                                                  -                                   -     -                                               -           -   
    SP4:              -     -     -     -                 -                                         -                                               -               
    SP5:                                                                                                                                            -           -   

    ExUns: 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b
    SP1:        -     -     -                     
    SP2:        -     -     -                     
    SP3:        -     -     -                     
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for RUFY1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RUFY1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTTGTGAC
    RUFY1 Expression
    About this image

    RUFY1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RUFY1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.306769

    UniProtKB/Swiss-Prot: RUFY1_HUMAN, Q96T51
    Tissue specificity: Broadly expressed, with highest levels in lung, testis, kidney and brain

        Custom PCR Arrays for RUFY1
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RUFY1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RUFY1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rufy11 , 5 RUN and FYVE domain containing 11, 5 87.48(n)1
    92.63(a)1
      11 (30.57 cM)5
    2167241  NM_172557.21  NP_766145.11 
     503892865 
    chicken
    (Gallus gallus)
    Aves RUFY11 RUN and FYVE domain containing 1 76.06(n)
    80.27(a)
      426519  NM_001257269.1  NP_001244198.1 
    lizard
    (Anolis carolinensis)
    Reptilia RUFY16
    RUN and FYVE domain containing 1
    84(a)
    1 ↔ 1
    2(140430441-140455809)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.168052 Transcribed sequence with weak similarity to protein more 77.05(n)    142018949 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003300771 RUN and FYVE domain-containing protein 1-like 64.56(n)
    64.46(a)
      100330077  XM_002667315.3  XP_002667361.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG310646
    --
    27(a)
    1 → many
    3R(23055227-23064803)


    ENSEMBL Gene Tree for RUFY1 (if available)
    TreeFam Gene Tree for RUFY1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RUFY1 gene
    RUNDC3A2  RUFY22  RUFY32  RUNDC3B2  
    Selected SIMAP similar genes for RUFY1 using alignment to 5 protein entries:     RUFY1_HUMAN (see all proteins) (see all similar genes):
    TMEM14B    TMEM44    C4orf22    PLA2G6    RUFY3    APOD
    NF2    AURA2    HECW1    LINC00596    ZNF212    ZNF564
    RUFY2    HMGA2    CTSS    FAM175A    SPATS2L    LYRM4

    Find genes that share paralogs with RUFY1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RUFY1 (see all 1533)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359854
    A breast cancer sample4--see VAR_0359852 C F mis40--------
    rs709977011,2
    C--178975978(+) AAAAAA/-TTAGC 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs339665691,2
    C--178976711(+) GGAGC-/TAGGAG 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1420476011,2
    C--178977141(+) AGATT-/AAAAAA 1 -- us2k10--------
    rs560957601,2
    C--178977155(+) AAAAA-/A/AA  
            
    TTCCT
    1 -- us2k11NA 2
    rs37339191,2
    C--178978002(-) CCCGCG/CAACAG 1 -- int11Minor allele frequency- C:0.50WA 2
    rs1161996711,2
    C,F--178978012(+) GCGGGC/TGGCGC 1 -- int12Minor allele frequency- T:0.24NA EA 240
    rs746023631,2
    C--178978099(+) CCGCA-/CCCGCG 1 -- int10--------
    rs755176951,2
    C--178978838(+) GAATC-/AAATTG 1 -- int10--------
    rs105562441,2
    C--178982623(+) CCAAC-/T/TTT 
            
    TTttt
    2 -- int1 cds11NA 2

    HapMap Linkage Disequilibrium report for RUFY1 (178977559 - 179037027 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RUFY1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5159CNV Insertion18451855
    nsv883270CNV Loss21882294
    dgv6399n71CNV Gain21882294
    dgv1880e1CNV Complex17122850
    nsv281OTHER Inversion15895083
    nsv7375OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RUFY1
    DNA2.0 Custom Variant and Variant Library Synthesis for RUFY1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610327    OMIM disorders: --


    Find genes that share disorders with RUFY1           About GenesLikeMe

    Genetic Association Database (GAD): RUFY1

    Export disorders for RUFY1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RUFY1 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with RUFY1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction between tyrosine kinase Etk and a RUN-domain and FYVE- domain containing protein RUFY1. A possible role of Etk in regulation of vesicle trafficking. (PubMed id 11877430)1, 2, 3 Yang J.... Qiu Y. (J. Biol. Chem. 2002)
    2. Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes. (PubMed id 14617813)1, 2 Fouraux M.A.... Pruijn G.J.M. (Mol. Biol. Cell 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (PLoS ONE 2012)
    8. Genome-wide association analysis of eating disorder-related symptoms, behaviors, and personality traits. (PubMed id 22911880)1 Boraska V....Zeggini E. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2012)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80230 HGNC: 19760 AceView: RUFY1 Ensembl:ENSG00000176783 euGenes: HUgn80230
    ECgene: RUFY1 Kegg: 80230 H-InvDB: RUFY1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RUFY1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RUFY1 gene:
    Search GeneIP for patents involving RUFY1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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