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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RTTN Gene

protein-coding GIFtS: 44
GCID: GC18M067730

rotatin

Explore 2 diseases affiliated with
RTTN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Rotatin¹
DKFZP434G145¹

External Ids:	HGNC: 18654¹	Entrez Gene: 25914²	Ensembl: ENSG00000176225⁷	OMIM: 610436⁵	UniProtKB: Q86VV8³

Export aliases for RTTN gene to outside databases

Previous GC identifers: GC18M067493 GC18M065820 GC18M065822 GC18M064389

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RTTN:

This gene encodes a large protein whose specific function is unknown. Absence of the orthologous protein in mouse

results in embryonic lethality with deficient axial rotation, abnormal differentiation of the neural tube, and

randomized looping of the heart tube during development. In human, mutations in this gene are associated with

polymicrogyria with seizures. In human fibroblasts this protein localizes at the ciliary basal bodies. Given the

intracellular localization of this protein and the phenotypic effects of mutations, this gene is suspected of playing

a role in the maintenance of normal ciliary structure which in turn effects the developmental process of left-right

organ specification, axial rotation, and perhaps notochord development. (provided by RefSeq, Jan 2013)

UniProtKB/Swiss-Prot: RTTN_HUMAN, Q86VV8

Function: Involved in the genetic cascade that governs left-right specification. Plays a role in the maintenance of a

normal ciliary structure. Required for correct asymmetric expression of NODAL, LEFTY and PITX2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_025028.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RTTN gene promoter:
AML1a NF-kappaB E47 C/EBPalpha AREB6 POU2F1 POU2F1a FOXO1a NF-kappaB1 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RTTN promoter sequence

Search SABiosciences Chromatin IP Primers for RTTN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RTTN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22.2 Ensembl cytogenetic band: 18q22.2 HGNC cytogenetic band: 18q22.1

RTTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTTN gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M067730: view genomic region (about GC identifiers)

Start:	67,671,029 bp from pter	End:	67,873,181 bp from pter
Size:	202,153 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RTTN_HUMAN, Q86VV8 (See protein sequence)

Recommended Name: Rotatin

Size: 2226 amino acids; 248630 Da

Subcellular location: Cytoplasm, cytoskeleton, cilium basal body. Note=Colocalizes with the basal bodies at the primary

cilium

Sequence caution: Sequence=BAC86583.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAC87292.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC87292.1;

Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=CAH18659.1; Type=Erroneous initiation;

Note=Translation N-terminally extended;

Secondary accessions: Q68CS9 Q6ZRL8 Q6ZTK3 Q86TG4 Q8N8N8 Q8TBQ4 Q96IN9 Q9UFJ4

Alternative splicing: 4 isoforms: Q86VV8-1 Q86VV8-2 Q86VV8-3 Q86VV8-4 (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for RTTN: NX_Q86VV8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86VV8

RTTN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_775901.3

ENSEMBL proteins:

ENSP00000255674 ENSP00000462675 ENSP00000462733 ENSP00000462926 ENSP00000399520

ENSP00000402352

Human Recombinant Protein Products:

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	Uscn Proteins for RTTN

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0036064	cilium basal body	IDA	--

RTTN for ontologies About GeneDecksing

RTTN Antibody Products:

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	Search ThermoFisher Antibodies for RTTN

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	Uscn ELISAs and CLIAs for RTTN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RTTN for domains About GeneDecksing

2 InterPro domains/families:

IPR011989 ARM-like

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q86VV8

ProtoNet protein and cluster: Q86VV8

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RTTN_HUMAN, Q86VV8

Function: Involved in the genetic cascade that governs left-right specification. Plays a role in the maintenance of a

normal ciliary structure. Required for correct asymmetric expression of NODAL, LEFTY and PITX2

miRNA Products:		OriGene 3'-UTR Clone: RTTN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RTTN
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RTTN
		SwitchGear 3'UTR luciferase reporter plasmid: RTTN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RTTN (see all 4) OriGene shRNA RFP: RTTN Browse OriGene siRNA
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Gene Editing
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		GenScript: all cDNA clones in your preferred vector: RTTN (NM_173630)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RTTN
		Search LifeMap BioReagents cell lines for RTTN

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTTN

1 GenomeRNAi human phenotype for RTTN:

Increased gamma-H2AX phosphory

Animal Models:
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Rttn):

cardiovascular system	embryogenesis	growth/size	homeostasis/metabolism	mortality/aging
nervous system

RTTN for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RTTN

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for RTTN (Q86VV8³ ENSP00000255674⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007368	determination of left/right symmetry	IEA	--

RTTN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RTTN
Search CenterWatch for drugs/clinical trials and news about RTTN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RTTN gene:

NM_173630.3

Unigene Cluster for RTTN:

Rotatin

Hs.654809 [show with all ESTs]

Unigene Representative Sequence: NM_173630

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000255674(uc002lkn.2 uc010dqp.2 uc002lko.2 uc002lkp.2 uc010xfb.1)

ENST00000578780 ENST00000583043 ENST00000581161 ENST00000580034 ENST00000579986

ENST00000579021 ENST00000583765 ENST00000581709 ENST00000584659 ENST00000581583(uc002lkq.1)

ENST00000437017 ENST00000454359

miRNA Products:		OriGene 3'-UTR Clone: RTTN Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RTTN
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RTTN
		SwitchGear 3'UTR luciferase reporter plasmid: RTTN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RTTN (see all 4) OriGene shRNA RFP: RTTN Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RTTN

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RTTN (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RTTN OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RTTN (NM_173630)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RTTN
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RTTN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RTTN Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RTTN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTTN

Additional cDNA sequence:

AK096404.1 AK126538.1 AK128137.1 AK129866.1 AL117635.1 BC007359.2 BC013774.1 BC026879.1

BC046222.2 BC046931.1 BC047602.1 BC143723.1 CR749799.1

11 DOTS entries:

DT.444094 DT.438604 DT.99997560 DT.100784064 DT.91942438 DT.415482 DT.100784063 DT.95189045

DT.121103742 DT.92002339 DT.99946562

24/80 AceView cDNA sequences (see all 80):

BU616804 T35272 AI470445 AI262864 AL117635 BC046931 AW269969 AA779492

CF527857 CK299447 BC047602 AI767701 AA381572 BI766357 D29317 AK129866

BM470706 NM_173630 CD515831 CA433110 BG283349 BC026879 BC013774 AA535713

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for RTTN About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^
SP1:																													-
SP2:
SP3:
SP4:
SP5:

ExUns:	25	^	26	^	27	^	28	^	29	^	30	^	31	^	32	^	33	^	34	^	35	^	36	^	37	^	38	^	39	^	40	^	41	^	42	^	43a	·	43b	^	44	^	45a	·	45b	^	46	^	47a	·	47b	^
SP1:																																											-				-
SP2:
SP3:																																											-
SP4:
SP5:																																															-

ExUns:	48	^	49	^	50a	·	50b	·	50c
SP1:
SP2:
SP3:
SP4:					-
SP5:

ECgene alternative splicing isoforms for RTTN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RTTN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See RTTN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RTTN

SOURCE GeneReport for Unigene cluster: Hs.654809

SABiosciences Custom PCR Arrays for RTTN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RTTN Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTTN

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTTN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RTTN gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rttn^{1 , 5}	rotatin^{1, 5}	83.9(n)¹ 82.41(a)¹		18 (58.93 cM)⁵ 246102¹ NM_175542.3¹ NP_780751.2¹ 88971790⁵
chicken (Gallus gallus)	Aves	RTTN¹	rotatin	69.33(n) 64.91(a)		421023 XM_001235278.2 XP_001235279.2
lizard (Anolis carolinensis)	Reptilia	RTTN⁶	--	64(a)	1 ↔ 1	4(46997164-47085562)
zebrafish (Danio rerio)	Actinopterygii	rttn¹	rotatin	55.11(n) 50.5(a)		100151439 XM_001920408.2 XP_001920443.2
fruit fly (Drosophila melanogaster)	Insecta	ana3⁶	anastral spindle 3	17(a)	1 ↔ 1	2R(8232591-8238583)

ENSEMBL Gene Tree for RTTN (if available)
TreeFam Gene Tree for RTTN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75500500^1,2	C,F,	--	67670618(+)	`TGTTTT/GGNNNN`	1	--	int¹		1		NA	120
rs116046546^1,2	C,F,	--	67670745(+)	`AGGAAA/G/TAAGAT`	1	--	int¹		1		WA	118
rs73970806^1,2	C,	--	67670760(+)	`TCACTA/GAAACT`	1	--	int¹		2		WA	120
rs73970807^1,2	C,	--	67670768(+)	`ACTTGC/GCTAAG`	1	--	int¹		2		WA	120
rs148797088^1,2		--	67670796(+)	`ATGTAC/GATTTA`	1	--	int¹		0	--	--	--	--
rs144931130^1,2		--	67670865(+)	`GTGGAC/TGCTCT`	1	--	int¹		0	--	--	--	--
rs147761277^1,2		--	67670975(+)	`TCTTAC/TTTCAA`	1	--	int¹		0	--	--	--	--
rs7998^1,2	C,F,O,A,H,	--	67671294(-)	`AAGACG/ATGCTA`	1	--	ut3¹ ese³		20		MN NA NS EA	2168
rs35558429^1,2	C,	--	67671432(+)	`TTCAAA/GTAATA`	2	Y	syn¹		2		NA WA	196
rs112768960^1,2	C,	--	67671532(+)	`ACTTAG/AGAGGC`	1	--	int¹		2		CSA WA	119

HapMap Linkage Disequilibrium report for RTTN (67671029 - 67873181 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RTTN
2 CNVs: 5061 7188
Human Gene Mutation Database (HGMD): RTTN

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RTTN

DNA2.0 Custom Variant and Variant Library Synthesis for RTTN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RTTN for disorders About GeneDecksing

OMIM gene information: 610436 OMIM disorders: --

UniProtKB/Swiss-Prot: RTTN_HUMAN, Q86VV8

Defects in RTTN are the cause of polymicrogyria with seizures (PMGYS) [MIM:614833]. A disease characterized by

many irregular small gyri in the brain surface and fusion of the molecular layer over multiple small gyri, which gives

a festooned appearance to the cortical surface, without abnormal neuronal migration. Polymicrogyria is a heterogeneous

disorder, considered

2 diseases for RTTN: About MalaCards

fanconi's anemia anemia

Export disorders for RTTN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RTTN gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with RTTN)

Utopia: connect your pdf to the dynamic
world of online information

RTTN mutations link primary cilia function to organization of the human cerebral cortex. (PubMed id 22939636)^{1, 2} Kheradmand Kia S....Mancini G.M. (2012)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Rotatin is a novel gene required for axial rotation and left-right specification in mouse embryos. (PubMed id 11900971)^{1, 3} Faisst A.M....Gruss P. (2002)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)¹ Vanderwerf S.M....Bagby G.C. (2009)
Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)² Choudhary C.... Mann M. (2009)
Ana3 is a conserved protein required for the structura l integrity of centrioles and basal bodies. (PubMed id 19948479)¹ Stevens N.R....Raff J.W. (2009)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)² Nusbaum C.... Lander E.S. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 25914	HGNC: 18654	AceView: RTTN	Ensembl:ENSG00000176225	euGenes: HUgn25914
ECgene: RTTN	H-InvDB: RTTN

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RTTN	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RTTN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RTTN gene:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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