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Aliases for RTP4 Gene

Aliases for RTP4 Gene

  • Receptor (Chemosensory) Transporter Protein 4 2 3 5
  • 28 KDa Interferon-Responsive Protein 3 4
  • 3CxxC-Type Zinc Finger Protein 4 3 4
  • Receptor Transporter Protein 4 2 3
  • Z3CXXC4 3 4
  • IFRG28 3 4
  • 28kD Interferon Responsive Protein 3
  • Receptor Transporting Protein 4 3
  • Zinc Finger, 3CxxC-Type 4 3
  • 3CxxC-Type 4 2
  • Zinc Finger 2

External Ids for RTP4 Gene

Previous GeneCards Identifiers for RTP4 Gene

  • GC03P188569
  • GC03P187086
  • GC03P184491

Summaries for RTP4 Gene

GeneCards Summary for RTP4 Gene

RTP4 (Receptor (Chemosensory) Transporter Protein 4) is a Protein Coding gene. An important paralog of this gene is RTP1.

UniProtKB/Swiss-Prot for RTP4 Gene

  • Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTP4 Gene

Genomics for RTP4 Gene

Regulatory Elements for RTP4 Gene

Enhancers for RTP4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RTP4 on UCSC Golden Path with GeneCards custom track

Promoters for RTP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RTP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for RTP4 Gene

Chromosome:
3
Start:
187,368,332 bp from pter
End:
187,372,076 bp from pter
Size:
3,745 bases
Orientation:
Plus strand

Genomic View for RTP4 Gene

Genes around RTP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTP4 Gene

Proteins for RTP4 Gene

  • Protein details for RTP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DX8-RTP4_HUMAN
    Recommended name:
    Receptor-transporting protein 4
    Protein Accession:
    Q96DX8
    Secondary Accessions:
    • Q9H4F3

    Protein attributes for RTP4 Gene

    Size:
    246 amino acids
    Molecular mass:
    27863 Da
    Quaternary structure:
    • Interacts with TASR16 (PubMed:16720576). Interacts with OPRD1 and OPRM1; the interaction promotes cell surface localization of the OPDR1-OPRM1 heterodimer (By similarity).

neXtProt entry for RTP4 Gene

Proteomics data for RTP4 Gene at MOPED

Post-translational modifications for RTP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RTP4 Gene

Domains & Families for RTP4 Gene

Protein Domains for RTP4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RTP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96DX8

UniProtKB/Swiss-Prot:

RTP4_HUMAN :
  • Belongs to the TMEM7 family.
Family:
  • Belongs to the TMEM7 family.
genes like me logo Genes that share domains with RTP4: view

Function for RTP4 Gene

Molecular function for RTP4 Gene

UniProtKB/Swiss-Prot Function:
Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity).
UniProtKB/Swiss-Prot Induction:
By interferons.

Gene Ontology (GO) - Molecular Function for RTP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031849 olfactory receptor binding IBA --
genes like me logo Genes that share ontologies with RTP4: view
genes like me logo Genes that share phenotypes with RTP4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RTP4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RTP4 Gene

Localization for RTP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTP4 Gene

Membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RTP4 Gene COMPARTMENTS Subcellular localization image for RTP4 gene
Compartment Confidence
cytosol 3
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for RTP4 Gene

Pathways & Interactions for RTP4 Gene

SuperPathways for RTP4 Gene

No Data Available

Interacting Proteins for RTP4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000259030%0d%0a9606.ENSP00000394624%0d%0a
Selected Interacting proteins: ENSP00000259030 for RTP4 Gene via STRING

Symbol External ID(s) Details
OPRM1

Gene Ontology (GO) - Biological Process for RTP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 16720576
genes like me logo Genes that share ontologies with RTP4: view

No data available for Pathways by source and SIGNOR curated interactions for RTP4 Gene

Drugs & Compounds for RTP4 Gene

No Compound Related Data Available

Transcripts for RTP4 Gene

mRNA/cDNA for RTP4 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(44) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RTP4 Gene

Receptor (chemosensory) transporter protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RTP4 Gene

No ASD Table

Relevant External Links for RTP4 Gene

GeneLoc Exon Structure for
RTP4
ECgene alternative splicing isoforms for
RTP4

Expression for RTP4 Gene

mRNA expression in normal human tissues for RTP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RTP4 Gene

This gene is overexpressed in CD8 Tcells (38.3) and Heart (30.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RTP4 Gene



SOURCE GeneReport for Unigene cluster for RTP4 Gene Hs.43388

mRNA Expression by UniProt/SwissProt for RTP4 Gene

Q96DX8-RTP4_HUMAN
Tissue specificity: Expressed in circumvallate papillae and testis.
genes like me logo Genes that share expression patterns with RTP4: view

Protein tissue co-expression partners for RTP4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RTP4 Gene

Orthologs for RTP4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RTP4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC532442 35
  • 76.56 (n)
  • 63.64 (a)
RTP4 36
  • 21 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RTP4 35
  • 71.11 (n)
  • 60.89 (a)
RTP4 36
  • 29 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rtp4 35
  • 59.18 (n)
  • 45.34 (a)
Rtp4 16
Rtp4 36
  • 38 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RTP4 35
  • 99.19 (n)
  • 99.18 (a)
RTP4 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rtp4 35
  • 65.05 (n)
  • 52.97 (a)
Species with no ortholog for RTP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RTP4 Gene

ENSEMBL:
Gene Tree for RTP4 (if available)
TreeFam:
Gene Tree for RTP4 (if available)

Paralogs for RTP4 Gene

Paralogs for RTP4 Gene

(1) SIMAP similar genes for RTP4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RTP4: view

Variants for RTP4 Gene

Sequence variations from dbSNP and Humsavar for RTP4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1047584 - 187,370,868(+) CTGGA(C/T)ATCCC reference, missense
rs35224605 - 187,371,135(-) TGCAG(C/T)TTTTT reference, missense
rs9028 -- 187,371,509(+) CTAGC(C/T)ATCCT utr-variant-3-prime
rs1914805 -- 187,367,525(-) ggggc(A/G)ggatc upstream-variant-2KB
rs1003995 -- 187,371,243(+) GTCAG(A/C)TGAGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RTP4 Gene

Variant ID Type Subtype PubMed ID
nsv878074 CNV Gain 21882294
nsv878075 CNV Gain 21882294

Variation tolerance for RTP4 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.88; 89.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RTP4 Gene

HapMap Linkage Disequilibrium report
RTP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTP4 Gene

Disorders for RTP4 Gene

Relevant External Links for RTP4

Genetic Association Database (GAD)
RTP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RTP4

No disorders were found for RTP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RTP4 Gene

Publications for RTP4 Gene

  1. Members of RTP and REEP gene families influence functional bitter taste receptor expression. (PMID: 16720576) Behrens M. … Meyerhof W. (J. Biol. Chem. 2006) 2 3 4 67
  2. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PMID: 16271481) Clark A.J. … Huebner A. (Trends Endocrinol. Metab. 2005) 2 3
  3. RTP family members induce functional expression of mammalian odorant receptors. (PMID: 15550249) Saito H. … Matsunami H. (Cell 2004) 2 3
  4. Receptor transporter protein 4 (RTP4) in endometrium, ovary, and peripheral blood leukocytes of pregnant and cyclic ewes. (PMID: 18495679) Gifford C.A. … Ott T.L. (Biol. Reprod. 2008) 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for RTP4 Gene

Sources for RTP4 Gene

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