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Aliases for RTP4 Gene

Aliases for RTP4 Gene

  • Receptor Transporter Protein 4 2 3 5
  • Receptor (Chemosensory) Transporter Protein 4 2 3
  • 28 KDa Interferon-Responsive Protein 3 4
  • 3CxxC-Type Zinc Finger Protein 4 3 4
  • Zinc Finger, 3CxxC-Type 4 2 3
  • Z3CXXC4 3 4
  • IFRG28 3 4
  • 28kD Interferon Responsive Protein 3
  • Receptor-Transporting Protein 4 3

External Ids for RTP4 Gene

Previous GeneCards Identifiers for RTP4 Gene

  • GC03P188569
  • GC03P187086
  • GC03P184491

Summaries for RTP4 Gene

GeneCards Summary for RTP4 Gene

RTP4 (Receptor Transporter Protein 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. An important paralog of this gene is RTP3.

UniProtKB/Swiss-Prot for RTP4 Gene

  • Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTP4 Gene

Genomics for RTP4 Gene

Regulatory Elements for RTP4 Gene

Enhancers for RTP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G187367 1.1 FANTOM5 ENCODE 24.9 +0.5 520 2.7 IRF2 CBX3 TAF1 ASH2L ZNF384 ZBTB40 RELA YY1 ZNF791 CBX5 RTP4 ENSG00000200418 SNORA4 SNORA81 TBCCD1 RPS20P14 BCL6 ENSG00000280270
GH03G187318 1.1 Ensembl ENCODE 11.3 -48.8 -48760 1.8 ZNF2 RAD21 RFX5 ZNF143 THAP11 SMARCA5 ZNF654 ZNF280D CEBPB REST SST MASP1 RTP4
GH03G187322 1 ENCODE 10.4 -44.8 -44775 1.5 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 SLC30A9 GATA2 ZNF143 FOS SST MASP1 RTP4
GH03G187209 1.1 Ensembl ENCODE 9.3 -157.8 -157803 1.3 HDAC1 TBL1XR1 TCF12 ZNF766 GATA2 ELK1 ZBTB11 NR2F2 NFIC SMARCA4 MASP1 RTP4 RTP1 LOC101929106 LOC105374260
GH03G187403 1.1 Ensembl ENCODE 7.2 +35.6 35585 1.7 GTF2F1 MXI1 JUN MAX BRCA1 ZNF507 RFX5 HIC1 ZNF366 SMC3 RTP4 ENSG00000239093 ENSG00000280270
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RTP4 on UCSC Golden Path with GeneCards custom track

Promoters for RTP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000163334 468 1201 IRF2 TAF1 ASH2L ZNF384 ZBTB40 RELA YY1 POLR2A EED STAT2

Genomic Location for RTP4 Gene

Chromosome:
3
Start:
187,368,332 bp from pter
End:
187,372,076 bp from pter
Size:
3,745 bases
Orientation:
Plus strand

Genomic View for RTP4 Gene

Genes around RTP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTP4 Gene

Proteins for RTP4 Gene

  • Protein details for RTP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DX8-RTP4_HUMAN
    Recommended name:
    Receptor-transporting protein 4
    Protein Accession:
    Q96DX8
    Secondary Accessions:
    • Q9H4F3

    Protein attributes for RTP4 Gene

    Size:
    246 amino acids
    Molecular mass:
    27863 Da
    Quaternary structure:
    • Interacts with TASR16 (PubMed:16720576). Interacts with OPRD1 and OPRM1; the interaction promotes cell surface localization of the OPDR1-OPRM1 heterodimer (By similarity).

neXtProt entry for RTP4 Gene

Post-translational modifications for RTP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RTP4 Gene

Domains & Families for RTP4 Gene

Protein Domains for RTP4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RTP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96DX8

UniProtKB/Swiss-Prot:

RTP4_HUMAN :
  • Belongs to the TMEM7 family.
Family:
  • Belongs to the TMEM7 family.
genes like me logo Genes that share domains with RTP4: view

Function for RTP4 Gene

Molecular function for RTP4 Gene

UniProtKB/Swiss-Prot Function:
Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity).
UniProtKB/Swiss-Prot Induction:
By interferons.

Gene Ontology (GO) - Molecular Function for RTP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16720576
GO:0031849 olfactory receptor binding IBA --
genes like me logo Genes that share ontologies with RTP4: view
genes like me logo Genes that share phenotypes with RTP4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RTP4

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RTP4 Gene

Localization for RTP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTP4 Gene

Membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTP4 gene
Compartment Confidence
cytosol 3
plasma membrane 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RTP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16720576
GO:0009986 cell surface IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RTP4: view

Pathways & Interactions for RTP4 Gene

genes like me logo Genes that share pathways with RTP4: view

Pathways by source for RTP4 Gene

Interacting Proteins for RTP4 Gene

Gene Ontology (GO) - Biological Process for RTP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 16720576
GO:0006612 protein targeting to membrane IDA 16720576
GO:0051205 protein insertion into membrane IBA --
genes like me logo Genes that share ontologies with RTP4: view

No data available for SIGNOR curated interactions for RTP4 Gene

Transcripts for RTP4 Gene

mRNA/cDNA for RTP4 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(44) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RTP4 Gene

Receptor (chemosensory) transporter protein 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTP4 Gene

No ASD Table

Relevant External Links for RTP4 Gene

GeneLoc Exon Structure for
RTP4
ECgene alternative splicing isoforms for
RTP4

Expression for RTP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RTP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RTP4 Gene

This gene is overexpressed in CD8 Tcells (38.3) and Heart (30.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RTP4 Gene



Protein tissue co-expression partners for RTP4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RTP4 Gene:

RTP4

SOURCE GeneReport for Unigene cluster for RTP4 Gene:

Hs.43388

mRNA Expression by UniProt/SwissProt for RTP4 Gene:

Q96DX8-RTP4_HUMAN
Tissue specificity: Expressed in circumvallate papillae and testis.

Evidence on tissue expression from TISSUES for RTP4 Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with RTP4: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTP4 Gene

Orthologs for RTP4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RTP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RTP4 34 35
  • 99.19 (n)
cow
(Bos Taurus)
Mammalia LOC532442 34
  • 76.56 (n)
RTP4 35
  • 21 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RTP4 34 35
  • 71.11 (n)
rat
(Rattus norvegicus)
Mammalia Rtp4 34
  • 65.05 (n)
mouse
(Mus musculus)
Mammalia Rtp4 34 16 35
  • 59.18 (n)
Species where no ortholog for RTP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RTP4 Gene

ENSEMBL:
Gene Tree for RTP4 (if available)
TreeFam:
Gene Tree for RTP4 (if available)

Paralogs for RTP4 Gene

Paralogs for RTP4 Gene

(1) SIMAP similar genes for RTP4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RTP4: view

Variants for RTP4 Gene

Sequence variations from dbSNP and Humsavar for RTP4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000412394 -- 187,368,028(+) CAGTG(A/G)CTGGC upstream-variant-2KB
rs1000685460 -- 187,367,921(+) CCTGC(A/C)TGCAG upstream-variant-2KB
rs1000688214 -- 187,369,094(+) GATAA(C/T)AGTAT intron-variant
rs1000741574 -- 187,369,522(+) TTCTC(C/T)GGTTC intron-variant
rs1001205774 -- 187,368,082(+) GGAGG(A/C)TCCGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RTP4 Gene

Variant ID Type Subtype PubMed ID
esv3569169 CNV loss 25503493
nsv1009271 CNV gain 25217958
nsv1014596 CNV gain 25217958

Variation tolerance for RTP4 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.88; 89.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RTP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RTP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTP4 Gene

Disorders for RTP4 Gene

Relevant External Links for RTP4

Genetic Association Database (GAD)
RTP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RTP4

No disorders were found for RTP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RTP4 Gene

Publications for RTP4 Gene

  1. Members of RTP and REEP gene families influence functional bitter taste receptor expression. (PMID: 16720576) Behrens M. … Meyerhof W. (J. Biol. Chem. 2006) 2 3 4 64
  2. RTP family members induce functional expression of mammalian odorant receptors. (PMID: 15550249) Saito H. … Matsunami H. (Cell 2004) 2 3 4 64
  3. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PMID: 16271481) Clark A.J. … Huebner A. (Trends Endocrinol. Metab. 2005) 2 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Receptor transporter protein 4 (RTP4) in endometrium, ovary, and peripheral blood leukocytes of pregnant and cyclic ewes. (PMID: 18495679) Gifford C.A. … Ott T.L. (Biol. Reprod. 2008) 22 64

Products for RTP4 Gene

Sources for RTP4 Gene

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