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Aliases for RTP4 Gene

Aliases for RTP4 Gene

  • Receptor (Chemosensory) Transporter Protein 4 2 3
  • 28 KDa Interferon-Responsive Protein 3 4
  • Receptor Transporter Protein 4 2 3
  • Z3CXXC4 3 4
  • IFRG28 3 4
  • 28kD Interferon Responsive Protein 3
  • 3CxxC-Type Zinc Finger Protein 4 4
  • Receptor Transporting Protein 4 3
  • Receptor-Transporting Protein 4 3
  • Zinc Finger, 3CxxC-Type 4 3
  • 3CxxC-Type 4 2
  • Zinc Finger 2

External Ids for RTP4 Gene

Previous GeneCards Identifiers for RTP4 Gene

  • GC03P188569
  • GC03P187086
  • GC03P184491

Summaries for RTP4 Gene

GeneCards Summary for RTP4 Gene

RTP4 (Receptor (Chemosensory) Transporter Protein 4) is a Protein Coding gene. An important paralog of this gene is RTP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTP4 Gene

Genomics for RTP4 Gene

Regulatory Elements for RTP4 Gene

Genomic Location for RTP4 Gene

187,368,332 bp from pter
187,372,076 bp from pter
3,745 bases
Plus strand

Genomic View for RTP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RTP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTP4 Gene

Proteins for RTP4 Gene

  • Protein details for RTP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor-transporting protein 4
    Protein Accession:
    Secondary Accessions:
    • Q9H4F3

    Protein attributes for RTP4 Gene

    246 amino acids
    Molecular mass:
    27863 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RTP4 Gene

Proteomics data for RTP4 Gene at MOPED

Post-translational modifications for RTP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RTP4 Gene

Domains for RTP4 Gene

Protein Domains for RTP4 Gene


Suggested Antigen Peptide Sequences for RTP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM7 family.
  • Belongs to the TMEM7 family.
genes like me logo Genes that share domains with RTP4: view

Function for RTP4 Gene

Molecular function for RTP4 Gene

UniProtKB/Swiss-Prot Induction:
By interferons

Gene Ontology (GO) - Molecular Function for RTP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16720576
genes like me logo Genes that share ontologies with RTP4: view

Phenotypes for RTP4 Gene

genes like me logo Genes that share phenotypes with RTP4: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RTP4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RTP4 Gene

Localization for RTP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTP4 Gene

Membrane; Single-pass type III membrane protein.

Subcellular locations from

Jensen Localization Image for RTP4 Gene COMPARTMENTS Subcellular localization image for RTP4 gene
Compartment Confidence
cytosol 3
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RTP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16720576
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RTP4: view

Pathways for RTP4 Gene

SuperPathways for RTP4 Gene

No Data Available

Interacting Proteins for RTP4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000259030 for RTP4 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for RTP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 16720576
GO:0006612 protein targeting to membrane IDA 16720576
genes like me logo Genes that share ontologies with RTP4: view

No data available for Pathways by source for RTP4 Gene

Transcripts for RTP4 Gene

mRNA/cDNA for RTP4 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(44) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RTP4 Gene

Receptor (chemosensory) transporter protein 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RTP4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTP4 Gene

No ASD Table

Relevant External Links for RTP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RTP4 Gene

mRNA expression in normal human tissues for RTP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RTP4 Gene

This gene is overexpressed in CD8 Tcells (38.3) and Heart (30.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RTP4 Gene

SOURCE GeneReport for Unigene cluster for RTP4 Gene Hs.43388

genes like me logo Genes that share expressions with RTP4: view

Expression partners for RTP4 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RTP4 Gene

Orthologs for RTP4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RTP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC532442 35
  • 76.56 (n)
  • 63.64 (a)
RTP4 36
  • 21 (a)
(Canis familiaris)
Mammalia RTP4 35
  • 71.11 (n)
  • 60.89 (a)
RTP4 36
  • 29 (a)
(Mus musculus)
Mammalia Rtp4 35
  • 59.18 (n)
  • 45.34 (a)
Rtp4 16
Rtp4 36
  • 38 (a)
(Pan troglodytes)
Mammalia RTP4 35
  • 99.19 (n)
  • 99.18 (a)
RTP4 36
  • 87 (a)
(Rattus norvegicus)
Mammalia Rtp4 35
  • 65.05 (n)
  • 52.97 (a)
Species with no ortholog for RTP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RTP4 Gene

Gene Tree for RTP4 (if available)
Gene Tree for RTP4 (if available)

Paralogs for RTP4 Gene

Paralogs for RTP4 Gene

(1) SIMAP similar genes for RTP4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RTP4: view

Variants for RTP4 Gene

Sequence variations from dbSNP and Humsavar for RTP4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs372538292 -- 187,370,091(+) AACCC(C/T)TGAAT intron-variant
rs372326120 -- 187,371,271(+) AGTGG(A/G)TATGA synonymous-codon, reference
rs371874359 -- 187,366,793(+) GCTCC(C/T)CTACG upstream-variant-2KB
rs371303895 -- 187,371,393(+) CCACT(G/T)TCTCT utr-variant-3-prime
rs370948271 -- 187,370,944(+) ATGCC(C/T)GAGTT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for RTP4 Gene

Variant ID Type Subtype PubMed ID
nsv878074 CNV Gain 21882294
nsv878075 CNV Gain 21882294

Relevant External Links for RTP4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTP4 Gene

Disorders for RTP4 Gene

Relevant External Links for RTP4

Genetic Association Database (GAD)

No disorders were found for RTP4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RTP4 Gene

Publications for RTP4 Gene

  1. RTP family members induce functional expression of mammalian odorant receptors. (PMID: 15550249) Saito H. … Matsunami H. (Cell 2004) 2 3 4
  2. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PMID: 16271481) Clark A.J. … Huebner A. (Trends Endocrinol. Metab. 2005) 2 3
  3. Members of RTP and REEP gene families influence functional bitter taste receptor expression. (PMID: 16720576) Behrens M. … Meyerhof W. (J. Biol. Chem. 2006) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Receptor transporter protein 4 (RTP4) in endometrium, ovary, and peripheral blood leukocytes of pregnant and cyclic ewes. (PMID: 18495679) Gifford C.A. … Ott T.L. (Biol. Reprod. 2008) 23

Products for RTP4 Gene

Sources for RTP4 Gene

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