RTP2 Gene
protein-coding GIFtS: 39
GCID: GC03M187416
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receptor (chemosensory) transporter protein 2(Previous name: receptor transporter protein 2 )
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Aliases
for RTP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Receptor (Chemosensory) Transporter Protein 21 2 | | Receptor Transporter Protein 21 2 | | MGC786651 | | Receptor Transporting Protein 22 | | Receptor-Transporting Protein 22 |
Export aliases for RTP2 gene to outside databasesPrevious GC identifers: GC03M188899 GC03M184820 |
Summaries
for RTP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RTP2_HUMAN, Q5QGT7Function: Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs (Bysimilarity)
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Genomic Views
for RTP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RTP2 gene promoter:
Nkx3-1 RFX1 Nkx3-1 v1 Nkx2-5 Nkx3-1 v2 HOXA5 FOXJ2 (long isoform) Nkx3-1 v3 FOXJ2 MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RTP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RTP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q27.3 Ensembl cytogenetic band: 3q27.3 HGNC cytogenetic band: 3q27.3RTP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M187416: view genomic region
(about GC identifiers)
Start:
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187,416,047 bp from pter |
End:
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187,420,345 bp from pter |
Size:
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4,299 bases |
Orientation:
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minus strand |
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Proteins
for RTP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RTP2_HUMAN, Q5QGT7 (See
protein sequence)Recommended Name: Receptor-transporting protein 2 Size: 225 amino acids; 26068 Da
Subunit: Interacts with olfactory receptors (By similarity)
Subcellular location: Cell membrane; Single-pass type III membrane protein (By similarity). Note=Effective cell surfaceexpression depends upon interaction with olfactory receptors (By similarity)
Secondary accessions: Q6NVH4Explore the universe of human proteins at neXtProt for RTP2: NX_Q5QGT7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5QGT7
RTP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001004312.2
ENSEMBL proteins: ENSP00000350976
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RTP2 for ontologies About GeneDecksing
RTP2 Antibody Products:
Assay Products for RTP2: |
Protein
Domains /
Families
for RTP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RTP2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5QGT7ProtoNet protein and cluster: Q5QGT7 UniProtKB/Swiss-Prot: RTP2_HUMAN, Q5QGT7Similarity: Belongs to the TMEM7 family |
Function
for RTP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RTP2_HUMAN, Q5QGT7Function: Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs (Bysimilarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RTP2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RTP2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for RTP2 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RTP2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTP2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTP2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
RTP2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Rtp2tm1Hmat for RTP2
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Rtp2):
RTP2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RTP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RTP2
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0051205 | protein insertion into membrane |
IDA | 15550249 |
RTP2 for ontologies About GeneDecksing
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Drugs & Compounds
for RTP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RTP2
Search CenterWatch for drugs/clinical trials and news about RTP2
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Transcripts
for RTP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RTP2 gene: NM_001004312.2 Unigene Cluster for RTP2: Receptor (chemosensory) transporter protein 2 Hs.567872 [show with all ESTs]Unigene Representative Sequence: BC0680811 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000358241(uc003fro.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RTP2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RTP2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for RTP2 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RTP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTP2 |
Additional cDNA sequence: AY562236.1 BC068081.1 1 DOTS entry: DT.100017374 7 AceView cDNA sequences: BQ672145 BQ668644 BQ674004 BC068081 BQ673426 NM_001004312 BQ671345
GeneLoc Exon Structure
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Expression
for RTP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RTP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCTTGAGAG
About this image
See RTP2 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.567872
SABiosciences Custom PCR Arrays for RTP2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RTP2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RTP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RTP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTP2 |
Orthologs
for RTP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RTP2 gene from 2/8 species (see all 8) About this table
ENSEMBL Gene Tree for RTP2 (if available)
TreeFam Gene Tree for RTP2 (if available) |
Paralogs
for RTP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RTP2 gene
- RTP42 RTP12 CXXC112 RTP32
2 SIMAP similar genes for RTP2 using alignment to 1 protein entry: RTP2_HUMAN:RTP1 RTP3
RTP2 for paralogs About GeneDecksing
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Genomic Variants
for RTP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for RTP2 (187416047 - 187420345 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RTP2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RTP2 |
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Disorders
/ Diseases
for RTP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RTP2 for disorders About GeneDecksing
OMIM gene information: 609138
OMIM disorders: --
2  diseases for RTP2: About MalaCardsparathyroid carcinoma carcinoma
1 disease from the University of Copenhagen DISEASES database for RTP2:Parathyroid carcinoma Export disorders for RTP2 gene to outside databases
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Publications
for RTP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RTP2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RTP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- RTP family members induce functional expression of mammalian odorant receptors. (PubMed id 15550249)1, 2, 3 Saito H....Matsunami H. (2004)
- Members of RTP and REEP gene families influence functional bitter taste receptor expression. (PubMed id 16720576)1, 3 Behrens M....Meyerhof W. (2006)
- Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PubMed id 16271481)1, 3 Clark A.J....Huebner A. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for RTP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing RTP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing RTP2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RTP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RTP2 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for RTP2 gene:
Search GeneIP for patents involving RTP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RTP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RTP2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RTP2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RTP2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RTP2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RTP2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RTP2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RTP2 | | OriGene Custom Protein Services for RTP2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RTP2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RTP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RTP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RTP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RTP2 |
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 |  |  |  | |
| | | | Search Tocris compounds for RTP2 |
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 | | | RTP2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTP2 |
|  |  |  | | | | ThermoFisher Antibodies for RTP2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTP2 |
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