Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RTP2 Gene

Aliases for RTP2 Gene

  • Receptor (Chemosensory) Transporter Protein 2 2 3
  • Receptor Transporting Protein 2 2 3
  • Receptor Transporter Protein 2 2 3
  • Z3CXXC2 3 4
  • 3CxxC-Type Zinc Finger Protein 2 4
  • Receptor-Transporting Protein 2 3
  • Zinc Finger, 3CxxC-Type 2 3
  • 3CxxC-Type 2 2
  • Zinc Finger 2

External Ids for RTP2 Gene

Previous GeneCards Identifiers for RTP2 Gene

  • GC03M188899
  • GC03M187416
  • GC03M184820

Summaries for RTP2 Gene

GeneCards Summary for RTP2 Gene

RTP2 (Receptor (Chemosensory) Transporter Protein 2) is a Protein Coding gene. GO annotations related to this gene include olfactory receptor binding. An important paralog of this gene is RTP1.

UniProtKB/Swiss-Prot for RTP2 Gene

  • Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTP2 Gene

Genomics for RTP2 Gene

Regulatory Elements for RTP2 Gene

Genomic Location for RTP2 Gene

Start:
187,698,259 bp from pter
End:
187,702,557 bp from pter
Size:
4,299 bases
Orientation:
Minus strand

Genomic View for RTP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RTP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTP2 Gene

Proteins for RTP2 Gene

  • Protein details for RTP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5QGT7-RTP2_HUMAN
    Recommended name:
    Receptor-transporting protein 2
    Protein Accession:
    Q5QGT7
    Secondary Accessions:
    • Q6NVH4

    Protein attributes for RTP2 Gene

    Size:
    225 amino acids
    Molecular mass:
    26068 Da
    Quaternary structure:
    • Interacts with olfactory receptors.

neXtProt entry for RTP2 Gene

Proteomics data for RTP2 Gene at MOPED

Post-translational modifications for RTP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RTP2 Gene

Domains for RTP2 Gene

Gene Families for RTP2 Gene

HGNC:
  • RTP :Receptor transporter proteins

Protein Domains for RTP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RTP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5QGT7

UniProtKB/Swiss-Prot:

RTP2_HUMAN :
  • Q5QGT7
Family:
  • Belongs to the TMEM7 family.
genes like me logo Genes that share domains with RTP2: view

Function for RTP2 Gene

Molecular function for RTP2 Gene

UniProtKB/Swiss-Prot Function: Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.

Gene Ontology (GO) - Molecular Function for RTP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0031849 olfactory receptor binding IMP 15550249
genes like me logo Genes that share ontologies with RTP2: view

Phenotypes for RTP2 Gene

MGI mutant phenotypes for RTP2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with RTP2: view

Animal Models for RTP2 Gene

MGI Knock Outs for RTP2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RTP2 Gene

Localization for RTP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTP2 Gene

Cell membrane; Single-pass type III membrane protein. Note=Effective cell surface expression depends upon interaction with olfactory receptors. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RTP2 Gene COMPARTMENTS Subcellular localization image for RTP2 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RTP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 15550249
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RTP2: view

Pathways for RTP2 Gene

SuperPathways for RTP2 Gene

No Data Available

Interacting Proteins for RTP2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000350976%0d%0a9606.ENSP00000404220%0d%0a
Selected Interacting proteins: ENSP00000350976 Q5QGT7-RTP2_HUMAN for RTP2 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for RTP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051205 protein insertion into membrane IDA 15550249
genes like me logo Genes that share ontologies with RTP2: view

No data available for Pathways by source for RTP2 Gene

Transcripts for RTP2 Gene

mRNA/cDNA for RTP2 Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RTP2 Gene

Receptor (chemosensory) transporter protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RTP2 Gene

No ASD Table

Relevant External Links for RTP2 Gene

GeneLoc Exon Structure for
RTP2
ECgene alternative splicing isoforms for
RTP2

Expression for RTP2 Gene

mRNA expression in normal human tissues for RTP2 Gene

mRNA differential expression in normal tissues according to GTEx for RTP2 Gene

This gene is overexpressed in Muscle - Skeletal (27.8) and Testis (23.2).

SOURCE GeneReport for Unigene cluster for RTP2 Gene Hs.567872

genes like me logo Genes that share expressions with RTP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for RTP2 Gene

Orthologs for RTP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RTP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RTP2 35
  • 98.22 (n)
  • 97.33 (a)
RTP2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RTP2 35
  • 91.78 (n)
  • 91.48 (a)
RTP2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BCL6 36
  • 87 (a)
OneToOne
RTP2 35
  • 89.33 (n)
  • 87.56 (a)
mouse
(Mus musculus)
Mammalia Rtp2 35
  • 88.22 (n)
  • 86.51 (a)
Rtp2 16
Rtp2 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rtp2 35
  • 87.44 (n)
  • 85.12 (a)
chicken
(Gallus gallus)
Aves LOC101751236 35
  • 53.9 (n)
  • 40.91 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
Species with no ortholog for RTP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RTP2 Gene

ENSEMBL:
Gene Tree for RTP2 (if available)
TreeFam:
Gene Tree for RTP2 (if available)

Paralogs for RTP2 Gene

Paralogs for RTP2 Gene

Selected SIMAP similar genes for RTP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RTP2: view

Variants for RTP2 Gene

Sequence variations from dbSNP and Humsavar for RTP2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1105911 -- 187,699,607(+) AACTA(C/G)CAAGT intron-variant
rs1523468 -- 187,698,465(-) ACATG(A/G)GCTTG utr-variant-3-prime
rs1851682 -- 187,698,301(-) ATAAT(G/T)GGGGG utr-variant-3-prime
rs1880095 -- 187,699,866(-) CCCAC(A/C)ACACT intron-variant
rs1880096 -- 187,699,784(-) AATAT(A/G)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RTP2 Gene

Variant ID Type Subtype PubMed ID
nsv878077 CNV Gain 21882294

Relevant External Links for RTP2 Gene

HapMap Linkage Disequilibrium report
RTP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTP2 Gene

Disorders for RTP2 Gene

(1) University of Copenhagen DISEASES for RTP2 Gene

genes like me logo Genes that share disorders with RTP2: view

No data available for UniProtKB/Swiss-Prot for RTP2 Gene

Publications for RTP2 Gene

  1. RTP family members induce functional expression of mammalian odorant receptors. (PMID: 15550249) Saito H. … Matsunami H. (Cell 2004) 2 3 4
  2. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PMID: 16271481) Clark A.J. … Huebner A. (Trends Endocrinol. Metab. 2005) 2 3
  3. Members of RTP and REEP gene families influence functional bitter taste receptor expression. (PMID: 16720576) Behrens M. … Meyerhof W. (J. Biol. Chem. 2006) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for RTP2 Gene

Sources for RTP2 Gene

Back to Top

Content