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RTP2 Gene

protein-coding   GIFtS: 41
GCID: GC03M187416

Receptor (Chemosensory) Transporter Protein 2

(Previous name: receptor transporter protein 2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Receptor (Chemosensory) Transporter Protein 21 2     Zinc Finger1
Receptor Transporter Protein 21 2     Z3CXXC22
Receptor Transporting Protein 21 2     Receptor-Transporting Protein 22
3CxxC-Type 21     Zinc Finger, 3CxxC-Type 22

External Ids:    HGNC: 324861   Entrez Gene: 3448922   Ensembl: ENSG000001984717   OMIM: 6091385   UniProtKB: Q5QGT73   

Export aliases for RTP2 gene to outside databases

Previous GC identifers: GC03M188899 GC03M184820


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RTP2 Gene:
RTP2 (receptor (chemosensory) transporter protein 2) is a protein-coding gene. GO annotations related to this gene include olfactory receptor binding. An important paralog of this gene is RTP4.

UniProtKB/Swiss-Prot: RTP2_HUMAN, Q5QGT7
Function: Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the RTP2 gene promoter:
         Nkx3-1   RFX1   Nkx3-1 v1   Nkx2-5   Nkx3-1 v2   HOXA5   FOXJ2 (long isoform)   Nkx3-1 v3   FOXJ2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRTP2 promoter sequence
   Search Chromatin IP Primers for RTP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RTP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27.3   Ensembl cytogenetic band:  3q27.3   HGNC cytogenetic band: 3q27.3

RTP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTP2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M187416:  view genomic region     (about GC identifiers)

Start:
187,416,047 bp from pter      End:
187,420,345 bp from pter
Size:
4,299 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RTP2_HUMAN, Q5QGT7 (See protein sequence)
Recommended Name: Receptor-transporting protein 2  
Size: 225 amino acids; 26068 Da
Subunit: Interacts with olfactory receptors (By similarity)
Secondary accessions: Q6NVH4

Explore the universe of human proteins at neXtProt for RTP2: NX_Q5QGT7

Explore proteomics data for RTP2 at MOPED


See RTP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001004312.2  
ENSEMBL proteins: 
 ENSP00000350976  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
RTP: Receptor transporter proteins

3 InterPro protein domains:
 IPR026096 R-trans_p/CXXC11
 IPR027377 Znf-3CxxC
 IPR026692 RTP1/RTP2

Graphical View of Domain Structure for InterPro Entry Q5QGT7

ProtoNet protein and cluster: Q5QGT7

UniProtKB/Swiss-Prot: RTP2_HUMAN, Q5QGT7
Similarity: Belongs to the TMEM7 family


Find genes that share domains with RTP2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: RTP2_HUMAN, Q5QGT7
Function: Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs
(By similarity)

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0031849olfactory receptor binding IMP15550249
     
Find genes that share ontologies with RTP2           About GenesLikeMe


Phenotypes:
     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rtp2):
 reproductive system 

Find genes that share phenotypes with RTP2           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Rtp2tm1Hmat for RTP2

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
RTP2_HUMAN, Q5QGT7: Cell membrane; Single-pass type III membrane protein (By similarity). Note=Effective cell
surface expression depends upon interaction with olfactory receptors (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5
cytosol3
extracellular1
mitochondrion1
nucleus1
peroxisome1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0009986cell surface IDA15550249
GO:0016021integral component of membrane IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RTP2
Interactions:

    Search GeneGlobe Interaction Network for RTP2

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0051205protein insertion into membrane IDA15550249

Find genes that share ontologies with RTP2           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for RTP2 gene: 
NM_001004312.2  

Unigene Cluster for RTP2:

Receptor (chemosensory) transporter protein 2
Hs.567872  [show with all ESTs]
Unigene Representative Sequence: BC068081
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000358241(uc003fro.1)
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Additional mRNA sequence: 

AY562236.1 BC068081.1 

1 DOTS entry:

DT.100017374 

7 AceView cDNA sequences:

BQ674004 BQ672145 BQ668644 NM_001004312 BQ671345 BC068081 BQ673426 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RTP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGCTTGAGAG
RTP2 Expression
About this image

RTP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RTP2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.567872
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for RTP2 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rtp21 , 5 receptor transporter protein 21, 5 88.22(n)1
86.51(a)1
  16 (15.12 cM)5
2240551  NM_001008230.31  NP_001008231.11 
 239255485 
chicken
(Gallus gallus)
Aves LOC1017512361 uncharacterized LOC101751236 53.9(n)
40.91(a)
  101751236  XM_004943336.1  XP_004943393.1 
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
35(a)
35(a)
many ↔ many
many ↔ many
GL343730.1(246662-248526)
GL343730.1(226946-229950)


ENSEMBL Gene Tree for RTP2 (if available)
TreeFam Gene Tree for RTP2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RTP2 gene
RTP42  RTP12  RTP52  RTP32  
2 SIMAP similar genes for RTP2 using alignment to 1 protein entry:     RTP2_HUMAN:
RTP1    RTP3

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RTP2 (see all 98)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs772447821,2
F--187415547(+) AATGAC/TGTTCT 1 -- ds50010--------
rs1167394741,2
C,F--187415629(+) GACTGA/GGGAAC 1 -- ds50011Minor allele frequency- G:0.03WA 118
rs1117128841,2
C,F--187415644(+) TTGTTA/GATGTT 1 -- ds50012Minor allele frequency- G:0.06WA NA 238
rs67706001,2
C,F,A,H--187415734(+) TTCCAG/ACCAAG 1 -- ds500115Minor allele frequency- A:0.22EA NS NA WA CSA 774
rs1928723341,2
--187415766(+) AAAAAA/CTAAGT 1 -- ds50010--------
rs622777971,2
C,F--187416015(+) GGTCCC/TTCCTG 1 -- ds50012Minor allele frequency- T:0.50NA CSA 4
rs50081951,2
C,F,H--187416026(+) TTGACC/TTAGTA 1 -- ds500116Minor allele frequency- T:0.49EA NS NA 1758
rs611980811,2
--187416041(+) CACCAA/GTCCTG 1 -- ds50010--------
rs1403935761,2
--187416070(+) ATTACA/GCCCTT 1 -- ut310--------
rs1849681351,2
--187416087(+) TTCCCC/TCAATT 1 -- ut310--------

HapMap Linkage Disequilibrium report for RTP2 (187416047 - 187420345 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for RTP2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv878077CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609138    OMIM disorders: --

1 disease from the University of Copenhagen DISEASES database for RTP2:
Parathyroid carcinoma

Find genes that share disorders with RTP2           About GenesLikeMe


Export disorders for RTP2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RTP2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with RTP2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. RTP family members induce functional expression of mammalian odorant receptors. (PubMed id 15550249)1, 2, 3 Saito H.... Matsunami H. (Cell 2004)
  2. Members of RTP and REEP gene families influence functional bitter taste receptor expression. (PubMed id 16720576)1, 3 Behrens M....Meyerhof W. (J. Biol. Chem. 2006)
  3. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PubMed id 16271481)1, 3 Clark A.J....Huebner A. (Trends Endocrinol. Metab. 2005)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. (PubMed id 23284291)1 Hancock D.B....London S.J. (PLoS Genet. 2012)
  6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 344892 HGNC: 32486 AceView: MGC78665 Ensembl:ENSG00000198471 euGenes: HUgn344892
ECgene: RTP2 H-InvDB: RTP2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RTP2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RTP2 gene:
Search GeneIP for patents involving RTP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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