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Aliases for RTP2 Gene

Aliases for RTP2 Gene

  • Receptor (Chemosensory) Transporter Protein 2 2 3 5
  • 3CxxC-Type Zinc Finger Protein 2 3 4
  • Receptor Transporting Protein 2 2 3
  • Receptor Transporter Protein 2 2 3
  • Z3CXXC2 3 4
  • Zinc Finger, 3CxxC-Type 2 3
  • 3CxxC-Type 2 2
  • Zinc Finger 2

External Ids for RTP2 Gene

Previous GeneCards Identifiers for RTP2 Gene

  • GC03M188899
  • GC03M187416
  • GC03M184820

Summaries for RTP2 Gene

GeneCards Summary for RTP2 Gene

RTP2 (Receptor (Chemosensory) Transporter Protein 2) is a Protein Coding gene. GO annotations related to this gene include olfactory receptor binding. An important paralog of this gene is RTP1.

UniProtKB/Swiss-Prot for RTP2 Gene

  • Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTP2 Gene

Genomics for RTP2 Gene

Regulatory Elements for RTP2 Gene

Enhancers for RTP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RTP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RTP2 Gene

187,698,259 bp from pter
187,716,720 bp from pter
18,462 bases
Minus strand

Genomic View for RTP2 Gene

Genes around RTP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTP2 Gene

Proteins for RTP2 Gene

  • Protein details for RTP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor-transporting protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6NVH4

    Protein attributes for RTP2 Gene

    225 amino acids
    Molecular mass:
    26068 Da
    Quaternary structure:
    • Interacts with olfactory receptors.

neXtProt entry for RTP2 Gene

Proteomics data for RTP2 Gene at MOPED

Post-translational modifications for RTP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RTP2 Gene

Domains & Families for RTP2 Gene

Protein Domains for RTP2 Gene


Suggested Antigen Peptide Sequences for RTP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM7 family.
  • Belongs to the TMEM7 family.
genes like me logo Genes that share domains with RTP2: view

Function for RTP2 Gene

Molecular function for RTP2 Gene

UniProtKB/Swiss-Prot Function:
Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.

Gene Ontology (GO) - Molecular Function for RTP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031849 olfactory receptor binding IMP 15550249
genes like me logo Genes that share ontologies with RTP2: view

Phenotypes for RTP2 Gene

MGI mutant phenotypes for RTP2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with RTP2: view

Animal Models for RTP2 Gene

MGI Knock Outs for RTP2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RTP2 Gene

Localization for RTP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTP2 Gene

Cell membrane; Single-pass type III membrane protein. Note=Effective cell surface expression depends upon interaction with olfactory receptors. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for RTP2 Gene COMPARTMENTS Subcellular localization image for RTP2 gene
Compartment Confidence
plasma membrane 4
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RTP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
genes like me logo Genes that share ontologies with RTP2: view

Pathways & Interactions for RTP2 Gene

SuperPathways for RTP2 Gene

No Data Available

Interacting Proteins for RTP2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000350976 Q5QGT7-RTP2_HUMAN for RTP2 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for RTP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IBA --
genes like me logo Genes that share ontologies with RTP2: view

No data available for Pathways by source and SIGNOR curated interactions for RTP2 Gene

Drugs & Compounds for RTP2 Gene

No Compound Related Data Available

Transcripts for RTP2 Gene

mRNA/cDNA for RTP2 Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RTP2 Gene

Receptor (chemosensory) transporter protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RTP2 Gene

No ASD Table

Relevant External Links for RTP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RTP2 Gene

mRNA expression in normal human tissues for RTP2 Gene

mRNA differential expression in normal tissues according to GTEx for RTP2 Gene

This gene is overexpressed in Muscle - Skeletal (x27.8) and Testis (x23.2).

SOURCE GeneReport for Unigene cluster for RTP2 Gene Hs.567872

mRNA Expression by UniProt/SwissProt for RTP2 Gene

Tissue specificity: Expressed in circumvallate papillae and testis.
genes like me logo Genes that share expression patterns with RTP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for RTP2 Gene

Orthologs for RTP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RTP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RTP2 35
  • 91.78 (n)
  • 91.48 (a)
RTP2 36
  • 91 (a)
(Canis familiaris)
Mammalia RTP2 35
  • 89.33 (n)
  • 87.56 (a)
BCL6 36
  • 87 (a)
(Mus musculus)
Mammalia Rtp2 35
  • 88.22 (n)
  • 86.51 (a)
Rtp2 16
Rtp2 36
  • 83 (a)
(Pan troglodytes)
Mammalia RTP2 35
  • 98.22 (n)
  • 97.33 (a)
RTP2 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Rtp2 35
  • 87.44 (n)
  • 85.12 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
(Gallus gallus)
Aves LOC101751236 35
  • 53.9 (n)
  • 40.91 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
-- 36
  • 35 (a)
Species with no ortholog for RTP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RTP2 Gene

Gene Tree for RTP2 (if available)
Gene Tree for RTP2 (if available)

Paralogs for RTP2 Gene

Paralogs for RTP2 Gene

(2) SIMAP similar genes for RTP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RTP2: view

Variants for RTP2 Gene

Sequence variations from dbSNP and Humsavar for RTP2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs11707167 - 187,698,931(+) CCCGC(C/T)GGGCG reference, missense
rs1851682 -- 187,698,301(-) ATAAT(G/T)GGGGG utr-variant-3-prime
rs1105911 -- 187,699,607(+) AACTA(C/G)CAAGT intron-variant
rs1880095 -- 187,699,866(-) CCCAC(A/C)ACACT intron-variant
rs1880096 -- 187,699,784(-) AATAT(A/G)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RTP2 Gene

Variant ID Type Subtype PubMed ID
nsv878077 CNV Gain 21882294

Variation tolerance for RTP2 Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.64; 93.14% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RTP2 Gene

Disorders for RTP2 Gene

Relevant External Links for RTP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RTP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RTP2 Gene

Publications for RTP2 Gene

  1. Members of RTP and REEP gene families influence functional bitter taste receptor expression. (PMID: 16720576) Behrens M. … Meyerhof W. (J. Biol. Chem. 2006) 2 3 4 67
  2. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PMID: 16271481) Clark A.J. … Huebner A. (Trends Endocrinol. Metab. 2005) 2 3
  3. RTP family members induce functional expression of mammalian odorant receptors. (PMID: 15550249) Saito H. … Matsunami H. (Cell 2004) 2 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. (PMID: 23284291) Hancock D.B. … London S.J. (PLoS Genet. 2012) 3

Products for RTP2 Gene

Sources for RTP2 Gene