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Aliases for RTP1 Gene

Aliases for RTP1 Gene

  • Receptor Transporter Protein 1 2 3 5
  • 3CxxC-Type Zinc Finger Protein 1 3 4
  • Zinc Finger, 3CxxC-Type 1 2 3
  • Z3CXXC1 3 4
  • Receptor (Chemosensory) Transporter Protein 1 3
  • Receptor Transporting Protein 1 2
  • Receptor-Transporting Protein 1 3

External Ids for RTP1 Gene

Previous GeneCards Identifiers for RTP1 Gene

  • GC03P188398
  • GC03P186915
  • GC03P184319

Summaries for RTP1 Gene

GeneCards Summary for RTP1 Gene

RTP1 (Receptor Transporter Protein 1) is a Protein Coding gene. Diseases associated with RTP1 include Taeniasis and Cysticercosis. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include olfactory receptor binding. An important paralog of this gene is RTP2.

UniProtKB/Swiss-Prot for RTP1 Gene

  • Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.

Additional gene information for RTP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTP1 Gene

Genomics for RTP1 Gene

GeneHancer (GH) Regulatory Elements for RTP1 Gene

Promoters and enhancers for RTP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I187197 Promoter 0.7 EPDnew 550.8 0.0 -4 0.1 MXI1 RFX1 BMI1 RTP1 LOC101929106 RPL39L
GH03I187182 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 12 -14.2 -14183 1.5 ZNF449 EBF1 MITF ZNF664 ZFHX2 POLR2A SCRT2 PRDM10 MAFK TRIM28 RTP1 RPL39L
GH03I187184 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.2 -11.3 -11295 3.4 HDAC1 ZNF2 BRCA1 ZNF335 ZNF766 FOS ATF7 SMARCC1 PHF21A REST RTP1 RPL39L
GH03I187209 Enhancer 1 Ensembl ENCODE 7.9 +13.0 13043 1.3 HDAC1 MEIS2 TEAD4 TAL1 ZNF644 FOSL1 CCNT2 TCF12 CTBP1 ZNF766 MASP1 RTP4 RTP1 LOC101929106 LOC105374260
GH03I187175 Enhancer 0.3 ENCODE 17 -22.3 -22294 0.5 POLR2A RTP1 RPL39L RPL39P19
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RTP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RTP1 gene promoter:

Genomic Locations for RTP1 Gene

Genomic Locations for RTP1 Gene
chr3:187,197,486-187,201,465
(GRCh38/hg38)
Size:
3,980 bases
Orientation:
Plus strand
chr3:186,915,274-186,919,253
(GRCh37/hg19)

Genomic View for RTP1 Gene

Genes around RTP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTP1 Gene

Proteins for RTP1 Gene

  • Protein details for RTP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59025-RTP1_HUMAN
    Recommended name:
    Receptor-transporting protein 1
    Protein Accession:
    P59025

    Protein attributes for RTP1 Gene

    Size:
    263 amino acids
    Molecular mass:
    30913 Da
    Quaternary structure:
    • Interacts with olfactory receptors.

neXtProt entry for RTP1 Gene

Post-translational modifications for RTP1 Gene

No Post-translational modifications

Other Protein References for RTP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RTP1 Gene

Domains & Families for RTP1 Gene

Gene Families for RTP1 Gene

Protein Domains for RTP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RTP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59025

UniProtKB/Swiss-Prot:

RTP1_HUMAN :
  • Belongs to the TMEM7 family.
Family:
  • Belongs to the TMEM7 family.
genes like me logo Genes that share domains with RTP1: view

Function for RTP1 Gene

Molecular function for RTP1 Gene

UniProtKB/Swiss-Prot Function:
Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.

Phenotypes From GWAS Catalog for RTP1 Gene

Gene Ontology (GO) - Molecular Function for RTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031849 olfactory receptor binding IMP 15550249
genes like me logo Genes that share ontologies with RTP1: view
genes like me logo Genes that share phenotypes with RTP1: view

Animal Models for RTP1 Gene

MGI Knock Outs for RTP1:

miRNA for RTP1 Gene

miRTarBase miRNAs that target RTP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RTP1 Gene

Localization for RTP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTP1 Gene

Cell membrane; Single-pass type III membrane protein. Note=Effective cell surface expression depends upon interaction with olfactory receptors. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTP1 gene
Compartment Confidence
plasma membrane 3
mitochondrion 3
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for RTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 15550249
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RTP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RTP1 Gene

Pathways & Interactions for RTP1 Gene

genes like me logo Genes that share pathways with RTP1: view

Pathways by source for RTP1 Gene

Interacting Proteins for RTP1 Gene

Gene Ontology (GO) - Biological Process for RTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IBA --
GO:0006612 protein targeting to membrane IBA --
GO:0051205 protein insertion into membrane IDA 15550249
genes like me logo Genes that share ontologies with RTP1: view

No data available for SIGNOR curated interactions for RTP1 Gene

Drugs & Compounds for RTP1 Gene

No Compound Related Data Available

Transcripts for RTP1 Gene

mRNA/cDNA for RTP1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RTP1 Gene

Receptor (chemosensory) transporter protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RTP1 Gene

No ASD Table

Relevant External Links for RTP1 Gene

GeneLoc Exon Structure for
RTP1
ECgene alternative splicing isoforms for
RTP1

Expression for RTP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RTP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RTP1 Gene

This gene is overexpressed in Brain - Cortex (x10.7), Brain - Frontal Cortex (BA9) (x9.1), Brain - Anterior cingulate cortex (BA24) (x8.2), and Brain - Hypothalamus (x7.2).

NURSA nuclear receptor signaling pathways regulating expression of RTP1 Gene:

RTP1

SOURCE GeneReport for Unigene cluster for RTP1 Gene:

Hs.518480

mRNA Expression by UniProt/SwissProt for RTP1 Gene:

P59025-RTP1_HUMAN
Tissue specificity: Expressed in testis.

Evidence on tissue expression from TISSUES for RTP1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with RTP1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTP1 Gene

Orthologs for RTP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RTP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RTP1 33 34
  • 99.37 (n)
cow
(Bos Taurus)
Mammalia RTP1 33 34
  • 92.9 (n)
dog
(Canis familiaris)
Mammalia RTP1 33 34
  • 92.52 (n)
rat
(Rattus norvegicus)
Mammalia Rtp1 33
  • 88.72 (n)
mouse
(Mus musculus)
Mammalia Rtp1 33 16 34
  • 87.83 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 79 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 36 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
Species where no ortholog for RTP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RTP1 Gene

ENSEMBL:
Gene Tree for RTP1 (if available)
TreeFam:
Gene Tree for RTP1 (if available)

Paralogs for RTP1 Gene

Paralogs for RTP1 Gene

(2) SIMAP similar genes for RTP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RTP1: view

Variants for RTP1 Gene

Sequence variations from dbSNP and Humsavar for RTP1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
VAR_036122 A breast cancer sample p.Arg124Ser
rs1000231808 -- 187,199,293(+) G/C intron_variant
rs1000442792 -- 187,197,184(+) A/C upstream_transcript_variant
rs1000808215 -- 187,198,128(+) A/G intron_variant
rs1000877117 -- 187,196,961(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RTP1 Gene

Variant ID Type Subtype PubMed ID
esv23875 CNV gain 19812545
nsv1004008 CNV gain 25217958
nsv1014596 CNV gain 25217958
nsv4158 CNV insertion 18451855
nsv508264 CNV deletion 20534489
nsv592710 CNV loss 21841781

Variation tolerance for RTP1 Gene

Residual Variation Intolerance Score: 68.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.96; 87.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RTP1 Gene

Human Gene Mutation Database (HGMD)
RTP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RTP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTP1 Gene

Disorders for RTP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RTP1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
taeniasis
  • beef tapeworm infection
cysticercosis
  • taeniasis
- elite association - COSMIC cancer census association via MalaCards
Search RTP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RTP1

genes like me logo Genes that share disorders with RTP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RTP1 Gene

Publications for RTP1 Gene

  1. Members of RTP and REEP gene families influence functional bitter taste receptor expression. (PMID: 16720576) Behrens M … Meyerhof W (The Journal of biological chemistry 2006) 2 3 4 58
  2. RTP family members induce functional expression of mammalian odorant receptors. (PMID: 15550249) Saito H … Matsunami H (Cell 2004) 2 3 4 58
  3. Synergism of accessory factors in functional expression of mammalian odorant receptors. (PMID: 17387175) Zhuang H … Matsunami H (The Journal of biological chemistry 2007) 3 22 58
  4. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PMID: 16271481) Clark AJ … Huebner A (Trends in endocrinology and metabolism: TEM 2005) 2 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for RTP1 Gene

Sources for RTP1 Gene

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