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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RTP1 Gene

protein-coding   GIFtS: 44
GCID: GC03P186915

Receptor (Chemosensory) Transporter Protein 1

(Previous name: receptor transporter protein 1)
  Search for RTP1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Receptor (Chemosensory) Transporter Protein 11 2
Receptor Transporter Protein 11 2
Receptor Transporting Protein 11 2
Receptor-Transporting Protein 12

External Ids:    HGNC: 285801   Entrez Gene: 1321122   Ensembl: ENSG000001750777   OMIM: 6091375   UniProtKB: P590253   

Export aliases for RTP1 gene to outside databases

Previous GC identifers: GC03P188398 GC03P184319


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RTP1 Gene: 
RTP1 (receptor (chemosensory) transporter protein 1) is a protein-coding gene. GO annotations related to this gene include olfactory receptor binding. An important paralog of this gene is RTP4.

UniProtKB/Swiss-Prot: RTP1_HUMAN, P59025
Function: Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RTP1 gene promoter:
         NF-1   oct-B3   oct-B2   AML1a   C/EBPalpha   POU2F1   POU2F1b   POU2F1a   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRTP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RTP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RTP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27.3   Ensembl cytogenetic band:  3q27.3   HGNC cytogenetic band: 3q27.3

RTP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTP1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P186915:  view genomic region     (about GC identifiers)

Start:
186,915,274 bp from pter      End:
186,919,253 bp from pter
Size:
3,980 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RTP1_HUMAN, P59025 (See protein sequence)
Recommended Name: Receptor-transporting protein 1  
Size: 263 amino acids; 30913 Da
Subunit: Interacts with olfactory receptors (By similarity)
Subcellular location: Cell membrane; Single-pass type III membrane protein (By similarity). Note=Effective cell
surface expression depends upon interaction with olfactory receptors (By similarity)

Explore the universe of human proteins at neXtProt for RTP1: NX_P59025

Explore proteomics data for RTP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P59025

  • RTP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RTP1 Protein Expression
    REFSEQ proteins: NP_714919.2  
    ENSEMBL proteins: 
     ENSP00000311712  

    Human Recombinant Protein Products for RTP1: 
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    Cloud-Clone Corp. Proteins for RTP1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0009986cell surface IDA15550249
    GO:0016021integral to membrane IEA--

    RTP1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RTP: Receptor transporter proteins

    3 InterPro protein domains:
     IPR026096 R-trans_p/CXXC11
     IPR027377 zf-3CxxC
     IPR026692 RTP1/RTP2

    Graphical View of Domain Structure for InterPro Entry P59025

    ProtoNet protein and cluster: P59025

    UniProtKB/Swiss-Prot: RTP1_HUMAN, P59025
    Similarity: Belongs to the TMEM7 family


    RTP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RTP1_HUMAN, P59025
    Function: Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs
    (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031849olfactory receptor binding IMP15550249
         
    RTP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rtp1):
     nervous system  reproductive system 

    RTP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rtp1tm1.1Hmat for RTP1

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    SwitchGear 3'UTR luciferase reporter plasmidRTP1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RTP1

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051205protein insertion into membrane IDA15550249

    RTP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RTP1

    Search CenterWatch for drugs/clinical trials and news about RTP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RTP1 gene: 
    NM_153708.2  

    Unigene Cluster for RTP1:

    Receptor (chemosensory) transporter protein 1
    Hs.518480  [show with all ESTs]
    Unigene Representative Sequence: BC065202
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000312295(uc003frg.3)
    miRNA
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    hsa-miR-3164 hsa-miR-1184 hsa-miR-544b hsa-miR-4251 hsa-miR-580 hsa-miR-1301 hsa-miR-3148 hsa-miR-2113
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTP1

    Additional mRNA sequence: 

    AY562235.1 BC034744.1 BC065202.1 

    1 DOTS entry:

    DT.95175457 

    7 AceView cDNA sequences:

    AI149844 BI822402 BC034744 BC065202 NM_153708 BI458240 AA885171 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RTP1 expression in normal human tissues (normalized intensities)      RTP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCCTTAGG
    RTP1 Expression
    About this image


    RTP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)
     
     Oral Cavity (Gastrointestinal Tract)
             saliva   

    See RTP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RTP1

    SOURCE GeneReport for Unigene cluster: Hs.518480
        SABiosciences Custom PCR Arrays for RTP1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RTP1 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rtp11 , 5 receptor transporter protein 11, 5 87.83(n)1
    90.49(a)1
      16 (14.21 cM)5
    2397661  NM_001004151.21  NP_001004151.11 
     234291335 
    chicken
    (Gallus gallus)
    Aves --
    --
    35(a)
    possible ortholog
    9(14359333-14360513)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    34(a)
    34(a)
    many ↔ many
    many ↔ many
    GL343730.1(226946-229950)
    GL343730.1(246662-248526)


    ENSEMBL Gene Tree for RTP1 (if available)
    TreeFam Gene Tree for RTP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RTP1 gene
    RTP42  RTP22  CXXC112  RTP32  
    2 SIMAP similar genes for RTP1 using alignment to 1 protein entry:     RTP1_HUMAN:
    RTP2    RTP3

    RTP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/199 SNPs in RTP1 are shown (see all 199)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361224
    A breast cancer sample4--see VAR_0361222 R S mis40--------
    rs98159571,2
    C,F,H--186913297(+) AATTGC/TTACCT 1 -- us2k19Minor allele frequency- T:0.16EA NS NA 540
    rs350623471,2
    C--186913317(+) TATGGA/-AATTT 1 -- us2k12Minor allele frequency- -:0.25NA 4
    rs593090451,2
    --186913319(+) TGGAAT/ATTTTT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs45649731,2
    C,F,A--186913333(+) TTTTTG/TTAAAA 1 -- us2k13Minor allele frequency- T:0.50NA WA 6
    rs579064981,2
    C--186913333(+) TTTTTG/-TAAAA 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1855111951,2
    --186913370(+) GTAATC/TCCAGC 1 -- us2k10--------
    rs106028061,2
    C--186913619(+) TCTGT-/AACAACAA 1 -- us2k10--------
    rs594743651,2
    C--186913641(+) CAACAACA/-CCACA 2 -- us2k1 cds11Minor allele frequency- -:0.50NA 2
    rs1914010431,2
    C--186913651(+) ACAACA/CAGGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RTP1 (186915274 - 186919253 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RTP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv4158CNV Insertion18451855
    nsv508264CNV Loss20534489
    esv23875CNV Gain19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RTP1 for disorders           About MalaCards
    OMIM gene information: 609137    OMIM disorders: --


    RTP1 for disorders           About GeneDecksing


    Export disorders for RTP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RTP1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RTP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RTP family members induce functional expression of mammalian odorant receptors. (PubMed id 15550249)1, 2, 3 Saito H....Matsunami H. (2004)
    2. Members of RTP and REEP gene families influence functional bitter taste receptor expression. (PubMed id 16720576)1, 3 Behrens M....Meyerhof W. (2006)
    3. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PubMed id 16271481)1, 3 Clark A.J....Huebner A. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Synergism of accessory factors in functional expression of mammalian odorant receptors. (PubMed id 17387175)1, 9 Zhuang H. and Matsunami H. (2007)
    6. Receptor-transporting protein 1 short (RTP1S) mediates translocation and activation of odorant receptors by acting through multiple st eps. (PubMed id 22570474)1 Wu L....Zhuang H. (2012)
    7. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 132112 HGNC: 28580 AceView: MGC35450 Ensembl:ENSG00000175077 euGenes: HUgn132112
    ECgene: RTP1 H-InvDB: RTP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RTP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RTP1 gene:
    Search GeneIP for patents involving RTP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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