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Aliases for RTP1 Gene

Aliases for RTP1 Gene

  • Receptor (Chemosensory) Transporter Protein 1 2 3
  • 3CxxC-Type Zinc Finger Protein 1 3 4
  • Receptor Transporting Protein 1 2 3
  • Receptor Transporter Protein 1 2 3
  • Z3CXXC1 3 4
  • Zinc Finger, 3CxxC-Type 1 3
  • 3CxxC-Type 1 2
  • Zinc Finger 2

External Ids for RTP1 Gene

Previous GeneCards Identifiers for RTP1 Gene

  • GC03P188398
  • GC03P186915
  • GC03P184319

Summaries for RTP1 Gene

GeneCards Summary for RTP1 Gene

RTP1 (Receptor (Chemosensory) Transporter Protein 1) is a Protein Coding gene. Diseases associated with RTP1 include taeniasis. GO annotations related to this gene include olfactory receptor binding. An important paralog of this gene is RTP2.

UniProtKB/Swiss-Prot for RTP1 Gene

  • Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTP1 Gene

Genomics for RTP1 Gene

Regulatory Elements for RTP1 Gene

Genomic Location for RTP1 Gene

Chromosome:
3
Start:
187,197,486 bp from pter
End:
187,201,465 bp from pter
Size:
3,980 bases
Orientation:
Plus strand

Genomic View for RTP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RTP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTP1 Gene

Proteins for RTP1 Gene

  • Protein details for RTP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59025-RTP1_HUMAN
    Recommended name:
    Receptor-transporting protein 1
    Protein Accession:
    P59025

    Protein attributes for RTP1 Gene

    Size:
    263 amino acids
    Molecular mass:
    30913 Da
    Quaternary structure:
    • Interacts with olfactory receptors.

neXtProt entry for RTP1 Gene

Proteomics data for RTP1 Gene at MOPED

Post-translational modifications for RTP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RTP1 Gene

Domains & Families for RTP1 Gene

Protein Domains for RTP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RTP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59025

UniProtKB/Swiss-Prot:

RTP1_HUMAN :
  • Belongs to the TMEM7 family.
Family:
  • Belongs to the TMEM7 family.
genes like me logo Genes that share domains with RTP1: view

Function for RTP1 Gene

Molecular function for RTP1 Gene

UniProtKB/Swiss-Prot Function:
Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.

Gene Ontology (GO) - Molecular Function for RTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031849 olfactory receptor binding IMP 15550249
genes like me logo Genes that share ontologies with RTP1: view

Phenotypes for RTP1 Gene

genes like me logo Genes that share phenotypes with RTP1: view

Animal Models for RTP1 Gene

MGI Knock Outs for RTP1:

Animal Model Products

miRNA for RTP1 Gene

miRTarBase miRNAs that target RTP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for RTP1 Gene

Localization for RTP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTP1 Gene

Cell membrane; Single-pass type III membrane protein. Note=Effective cell surface expression depends upon interaction with olfactory receptors. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RTP1 Gene COMPARTMENTS Subcellular localization image for RTP1 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for RTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 15550249
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RTP1: view

Pathways & Interactions for RTP1 Gene

SuperPathways for RTP1 Gene

No Data Available

Interacting Proteins for RTP1 Gene

Gene Ontology (GO) - Biological Process for RTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IBA --
GO:0006612 protein targeting to membrane IBA --
GO:0051205 protein insertion into membrane IDA 15550249
genes like me logo Genes that share ontologies with RTP1: view

No data available for Pathways by source and SIGNOR curated interactions for RTP1 Gene

Drugs & Compounds for RTP1 Gene

No Compound Related Data Available

Transcripts for RTP1 Gene

mRNA/cDNA for RTP1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RTP1 Gene

Receptor (chemosensory) transporter protein 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RTP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTP1 Gene

No ASD Table

Relevant External Links for RTP1 Gene

GeneLoc Exon Structure for
RTP1
ECgene alternative splicing isoforms for
RTP1

Expression for RTP1 Gene

mRNA expression in normal human tissues for RTP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RTP1 Gene

This gene is overexpressed in Brain - Cortex (x10.7), Brain - Frontal Cortex (BA9) (x9.1), Brain - Anterior cingulate cortex (BA24) (x8.2), and Brain - Hypothalamus (x7.2).

SOURCE GeneReport for Unigene cluster for RTP1 Gene Hs.518480

mRNA Expression by UniProt/SwissProt for RTP1 Gene

P59025-RTP1_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with RTP1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for RTP1 Gene

Orthologs for RTP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RTP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RTP1 35
  • 92.9 (n)
  • 93.16 (a)
RTP1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RTP1 35
  • 92.52 (n)
  • 92.78 (a)
RTP1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rtp1 35
  • 87.83 (n)
  • 90.49 (a)
Rtp1 16
Rtp1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RTP1 35
  • 99.37 (n)
  • 99.24 (a)
RTP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rtp1 35
  • 88.72 (n)
  • 92.02 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
Species with no ortholog for RTP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RTP1 Gene

ENSEMBL:
Gene Tree for RTP1 (if available)
TreeFam:
Gene Tree for RTP1 (if available)

Paralogs for RTP1 Gene

Paralogs for RTP1 Gene

(2) SIMAP similar genes for RTP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RTP1: view

Variants for RTP1 Gene

Sequence variations from dbSNP and Humsavar for RTP1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2111652 -- 187,196,542(-) CATAA(A/T)ACCCC upstream-variant-2KB
rs4564973 -- 187,195,545(+) TTTTT(G/T)TAAAA upstream-variant-2KB
rs4686862 -- 187,196,039(+) ATTTT(A/G)AGTCC upstream-variant-2KB
rs4686863 -- 187,196,190(+) GTTGT(C/T)TCTAA upstream-variant-2KB
rs9815957 -- 187,195,509(+) AATTG(C/T)TACCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RTP1 Gene

Variant ID Type Subtype PubMed ID
nsv4158 CNV Insertion 18451855
nsv508264 CNV Loss 20534489
esv23875 CNV Gain 19812545

Variation tolerance for RTP1 Gene

Residual Variation Intolerance Score: 68.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.96; 87.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RTP1 Gene

HapMap Linkage Disequilibrium report
RTP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTP1 Gene

Disorders for RTP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RTP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
taeniasis
  • teniasis
- elite association
Search RTP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RTP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RTP1
genes like me logo Genes that share disorders with RTP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RTP1 Gene

Publications for RTP1 Gene

  1. Synergism of accessory factors in functional expression of mammalian odorant receptors. (PMID: 17387175) Zhuang H. … Matsunami H. (J. Biol. Chem. 2007) 23 67
  2. Members of RTP and REEP gene families influence functional bitter taste receptor expression. (PMID: 16720576) Behrens M. … Meyerhof W. (J. Biol. Chem. 2006) 2 67
  3. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. (PMID: 16271481) Clark A.J. … Huebner A. (Trends Endocrinol. Metab. 2005) 2 67
  4. RTP family members induce functional expression of mammalian odorant receptors. (PMID: 15550249) Saito H. … Matsunami H. (Cell 2004) 2 67
  5. Receptor-transporting protein 1 short (RTP1S) mediates translocation and activation of odorant receptors by acting through multiple steps. (PMID: 22570474) Wu L. … Zhuang H. (J. Biol. Chem. 2012) 67

Products for RTP1 Gene

Sources for RTP1 Gene

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