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Aliases for RTN4RL2 Gene

Aliases for RTN4RL2 Gene

  • Reticulon 4 Receptor-Like 2 2 3 5
  • Nogo-66 Receptor-Related Protein 2 3 4
  • Nogo-66 Receptor Homolog 1 3 4
  • Nogo Receptor-Like 3 3 4
  • NGRH1 3 4
  • NgR2 3 4
  • Reticulon-4 Receptor-Like 2 3
  • NGRL3 4

External Ids for RTN4RL2 Gene

Previous GeneCards Identifiers for RTN4RL2 Gene

  • GC11P057003
  • GC11P056984
  • GC11P057228
  • GC11P053577

Summaries for RTN4RL2 Gene

GeneCards Summary for RTN4RL2 Gene

RTN4RL2 (Reticulon 4 Receptor-Like 2) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. GO annotations related to this gene include receptor activity. An important paralog of this gene is RTN4RL1.

UniProtKB/Swiss-Prot for RTN4RL2 Gene

  • May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTN4RL2 Gene

Genomics for RTN4RL2 Gene

Regulatory Elements for RTN4RL2 Gene

Enhancers for RTN4RL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F057431 1.7 FANTOM5 Ensembl ENCODE 21.6 -26.8 -26837 3.8 ATF1 ARID4B YY1 FOS SP5 MIER2 PPARG PPARGC1A KAT8 SSRP1 RTN4RL2 TIMM10 P2RX3 SSRP1 SLC43A1 SERPING1 SLC43A3 RNA5SP341
GH11F057481 1.2 Ensembl ENCODE 13.2 +23.3 23340 4.6 ZFP64 ZNF48 GLIS2 ZNF143 REST MEF2D SMARCA4 GLIS1 KDM1A CTCF TIMM10 SMTNL1 RTN4RL2 RN7SKP259 SLC43A1 P2RX3 SSRP1 SLC43A3 ENSG00000254979 UBE2L6
GH11F057405 1.4 FANTOM5 Ensembl ENCODE 11.3 -53.9 -53859 2.6 PKNOX1 ESRRA MXI1 JUN MAX EBF1 RELA POLR2A ADNP EED SLC43A3 P2RX3 RN7SKP259 RTN4RL2 SSRP1 PRG2 TIMM10 UBE2L6 ZDHHC5 GC11M057408
GH11F057496 1.3 Ensembl ENCODE 11.7 +39.4 39392 6.7 PKNOX1 ARID4B DMAP1 ZNF48 YY1 ZNF121 GLIS2 KLF7 FOS SP3 TIMM10 RPS4XP13 OR5AZ1P OR9Q2 OR5B1P OR5B15P BTBD18 RTN4RL2 RN7SKP259 MIR130A
GH11F057357 1.2 Ensembl ENCODE 11.2 -101.5 -101459 3.0 HDAC1 ATF1 CBX3 PKNOX1 TBL1XR1 ARNT CHAMP1 ZNF766 GATA2 SCRT2 PRG2 P2RX3 ENSG00000254979 SLC43A3 SSRP1 RN7SKP259 RTN4RL2 TNKS1BP1 ENSG00000254662 SLC43A1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RTN4RL2 on UCSC Golden Path with GeneCards custom track

Promoters for RTN4RL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001051532 363 1401 KLF17 GLIS2 ZNF366 SMARCB1 NR2F2 ZFP69B MAFF ZNF341 GLIS1 IKZF1

Genomic Location for RTN4RL2 Gene

Chromosome:
11
Start:
57,460,537 bp from pter
End:
57,477,539 bp from pter
Size:
17,003 bases
Orientation:
Plus strand

Genomic View for RTN4RL2 Gene

Genes around RTN4RL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTN4RL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTN4RL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTN4RL2 Gene

Proteins for RTN4RL2 Gene

  • Protein details for RTN4RL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UN3-R4RL2_HUMAN
    Recommended name:
    Reticulon-4 receptor-like 2
    Protein Accession:
    Q86UN3
    Secondary Accessions:
    • Q0GGW3
    • Q17RL9
    • Q6X813

    Protein attributes for RTN4RL2 Gene

    Size:
    420 amino acids
    Molecular mass:
    46106 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RTN4RL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RTN4RL2 Gene

Post-translational modifications for RTN4RL2 Gene

  • Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; where BRE is released as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein.
  • Glycosylation at Asn 50 and Thr 316
  • Modification sites at PhosphoSitePlus

Other Protein References for RTN4RL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for RTN4RL2

No data available for DME Specific Peptides for RTN4RL2 Gene

Domains & Families for RTN4RL2 Gene

Suggested Antigen Peptide Sequences for RTN4RL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q86UN3

UniProtKB/Swiss-Prot:

R4RL2_HUMAN :
  • Contains 1 LRRCT domain.
  • Belongs to the Nogo receptor family.
  • Contains 8 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Family:
  • Belongs to the Nogo receptor family.
Similarity:
  • Contains 8 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with RTN4RL2: view

No data available for Gene Families for RTN4RL2 Gene

Function for RTN4RL2 Gene

Molecular function for RTN4RL2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.

Gene Ontology (GO) - Molecular Function for RTN4RL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
GO:0004872 receptor activity IDA 12694398
genes like me logo Genes that share ontologies with RTN4RL2: view
genes like me logo Genes that share phenotypes with RTN4RL2: view

Animal Models for RTN4RL2 Gene

MGI Knock Outs for RTN4RL2:

Animal Model Products

  • Taconic Biosciences Mouse Models for RTN4RL2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RTN4RL2 Gene

Localization for RTN4RL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTN4RL2 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Note=Localized to the surface of neurons, including axons.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTN4RL2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RTN4RL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IEA --
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 20463223
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RTN4RL2: view

Pathways & Interactions for RTN4RL2 Gene

genes like me logo Genes that share pathways with RTN4RL2: view

Gene Ontology (GO) - Biological Process for RTN4RL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IBA --
GO:0019221 cytokine-mediated signaling pathway IBA --
GO:0031103 axon regeneration TAS 14664809
GO:0046426 negative regulation of JAK-STAT cascade IBA --
genes like me logo Genes that share ontologies with RTN4RL2: view

No data available for SIGNOR curated interactions for RTN4RL2 Gene

Transcripts for RTN4RL2 Gene

mRNA/cDNA for RTN4RL2 Gene

Unigene Clusters for RTN4RL2 Gene

Reticulon 4 receptor-like 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTN4RL2 Gene

No ASD Table

Relevant External Links for RTN4RL2 Gene

GeneLoc Exon Structure for
RTN4RL2
ECgene alternative splicing isoforms for
RTN4RL2

Expression for RTN4RL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RTN4RL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RTN4RL2 Gene

This gene is overexpressed in Liver (x8.5), Brain - Cortex (x6.6), Brain - Anterior cingulate cortex (BA24) (x5.7), Brain - Frontal Cortex (BA9) (x5.3), and Thyroid (x4.4).

Protein differential expression in normal tissues from HIPED for RTN4RL2 Gene

This gene is overexpressed in Serum (49.4) and Thyroid (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RTN4RL2 Gene



NURSA nuclear receptor signaling pathways regulating expression of RTN4RL2 Gene:

RTN4RL2

SOURCE GeneReport for Unigene cluster for RTN4RL2 Gene:

Hs.502618

mRNA Expression by UniProt/SwissProt for RTN4RL2 Gene:

Q86UN3-R4RL2_HUMAN
Tissue specificity: Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid.
genes like me logo Genes that share expression patterns with RTN4RL2: view

Primer Products

No data available for Protein tissue co-expression partners for RTN4RL2 Gene

Orthologs for RTN4RL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RTN4RL2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia RTN4RL2 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RTN4RL2 34 35
  • 91.28 (n)
mouse
(Mus musculus)
Mammalia Rtn4rl2 34 16 35
  • 91.25 (n)
rat
(Rattus norvegicus)
Mammalia Rtn4rl2 34
  • 91.17 (n)
chimpanzee
(Pan troglodytes)
Mammalia RTN4RL2 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RTN4RL2 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves RTN4RL2 34 35
  • 73.49 (n)
lizard
(Anolis carolinensis)
Reptilia RTN4RL2 35
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rtn4rl2b 34 35
  • 57.08 (n)
rtn4rl2a 35
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1504 35
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lron-12 35
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
OneToMany
Species where no ortholog for RTN4RL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RTN4RL2 Gene

ENSEMBL:
Gene Tree for RTN4RL2 (if available)
TreeFam:
Gene Tree for RTN4RL2 (if available)

Paralogs for RTN4RL2 Gene

Paralogs for RTN4RL2 Gene

(4) SIMAP similar genes for RTN4RL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RTN4RL2: view

Variants for RTN4RL2 Gene

Sequence variations from dbSNP and Humsavar for RTN4RL2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10896619 -- 57,465,764(+) ACTCT(C/T)TAGCC intron-variant
rs10896620 -- 57,465,780(+) GCTCT(C/T)TGGGC intron-variant
rs111564677 -- 57,470,655(+) TAATT(-/ACT)ACTAC intron-variant
rs111631302 -- 57,464,520(+) TAGGG(A/G)AGTGG intron-variant
rs111742277 -- 57,465,236(+) TGGCT(C/G)AGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RTN4RL2 Gene

Variant ID Type Subtype PubMed ID
esv2674981 CNV deletion 23128226

Variation tolerance for RTN4RL2 Gene

Residual Variation Intolerance Score: 38.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RTN4RL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RTN4RL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTN4RL2 Gene

Disorders for RTN4RL2 Gene

Relevant External Links for RTN4RL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RTN4RL2

No disorders were found for RTN4RL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RTN4RL2 Gene

Publications for RTN4RL2 Gene

  1. Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. (PMID: 12839991) Barton W.A. … Nikolov D.B. (EMBO J. 2003) 3 4 22 64
  2. Two novel mammalian nogo receptor homologs differentially expressed in the central and peripheral nervous systems. (PMID: 14664809) Lauren J. … Timmusk T. (Mol. Cell. Neurosci. 2003) 3 4 22 64
  3. Synaptic function for the Nogo-66 receptor NgR1: regulation of dendritic spine morphology and activity-dependent synaptic strength. (PMID: 18337405) Lee H. … Giger R.J. (J. Neurosci. 2008) 3 22 64
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4 64
  5. Ectodomain shedding of human Nogo-66 receptor homologue-1 by zinc metalloproteinases. (PMID: 15629437) Walmsley A.R. … Frentzel S. (Biochem. Biophys. Res. Commun. 2005) 3 4 64

Products for RTN4RL2 Gene

Sources for RTN4RL2 Gene

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