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Aliases for RTN4RL2 Gene

Aliases for RTN4RL2 Gene

  • Reticulon 4 Receptor Like 2 2 3 5
  • Nogo-66 Receptor-Related Protein 2 3 4
  • Nogo-66 Receptor Homolog 1 3 4
  • Nogo Receptor-Like 3 3 4
  • NGRH1 3 4
  • NgR2 3 4
  • Reticulon-4 Receptor-Like 2 3
  • NGRL3 4

External Ids for RTN4RL2 Gene

Previous GeneCards Identifiers for RTN4RL2 Gene

  • GC11P057003
  • GC11P056984
  • GC11P057228
  • GC11P053577

Summaries for RTN4RL2 Gene

GeneCards Summary for RTN4RL2 Gene

RTN4RL2 (Reticulon 4 Receptor Like 2) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. GO annotations related to this gene include receptor activity. An important paralog of this gene is RTN4RL1.

UniProtKB/Swiss-Prot for RTN4RL2 Gene

  • Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).

Additional gene information for RTN4RL2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTN4RL2 Gene

Genomics for RTN4RL2 Gene

Regulatory Elements for RTN4RL2 Gene

Enhancers for RTN4RL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H057405 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -53.8 -53771 2 PKNOX1 BATF ATF7 ETV6 RUNX3 CREM IKZF2 JUNB REST ZNF592 SLC43A3 P2RX3 RN7SKP259 RTN4RL2 SSRP1 PRG2 TIMM10 UBE2L6 ZDHHC5 GC11M057408
GH11H057434 1.5 Ensembl ENCODE dbSUPER 12.2 -25.6 -25640 0 FOXA2 ATF1 ARID4B SIN3A YY1 TCF12 ZNF766 FOS SP5 REST RTN4RL2 TIMM10 SSRP1 P2RX3 SLC43A1 SERPING1 SLC43A3 RNA5SP341
GH11H057496 1.5 Ensembl ENCODE dbSUPER 11.8 +39.4 39392 6 HDGF PKNOX1 FOXA2 ARID4B DMAP1 YY1 ZNF121 GLIS2 FOS KLF7 TIMM10 RPS4XP13 OR5AZ1P OR9Q2 OR5B1P OR5B15P BTBD18 RTN4RL2 RN7SKP259 MIR130A
GH11H057431 1.8 FANTOM5 Ensembl ENCODE dbSUPER 8.5 -27.8 -27797 1 HDAC1 ELF3 TBP ATF1 TBL1XR1 RAD21 TCF12 ZNF766 EGR1 FOS RTN4RL2 TIMM10 SLC43A3 RNA5SP341
GH11H057481 1.1 Ensembl ENCODE 13.2 +22.1 22140 2 RB1 ZFP64 KLF17 RAD21 GLIS2 ZNF366 ZNF143 RUNX3 SMARCA5 USF2 TIMM10 SMTNL1 RTN4RL2 RN7SKP259 SLC43A1 P2RX3 SSRP1 SLC43A3 ENSG00000254979 UBE2L6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RTN4RL2 on UCSC Golden Path with GeneCards custom track

Promoters for RTN4RL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000039885 63 801 CTCF KLF1 ZNF777 RB1 KLF17 ZIC2 POLR2A ZNF143 PRDM10 TRIM24

Genomic Location for RTN4RL2 Gene

Chromosome:
11
Start:
57,460,537 bp from pter
End:
57,477,539 bp from pter
Size:
17,003 bases
Orientation:
Plus strand

Genomic View for RTN4RL2 Gene

Genes around RTN4RL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTN4RL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTN4RL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTN4RL2 Gene

Proteins for RTN4RL2 Gene

  • Protein details for RTN4RL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UN3-R4RL2_HUMAN
    Recommended name:
    Reticulon-4 receptor-like 2
    Protein Accession:
    Q86UN3
    Secondary Accessions:
    • Q0GGW3
    • Q17RL9
    • Q6X813

    Protein attributes for RTN4RL2 Gene

    Size:
    420 amino acids
    Molecular mass:
    46106 Da
    Quaternary structure:
    • Interaction with MAG is controversial, and may be indirect (Probable). Does not interact with MAG, OMG and RTN4 (PubMed:12839991). Interacts with MAG (By similarity).

    Alternative splice isoforms for RTN4RL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RTN4RL2 Gene

Post-translational modifications for RTN4RL2 Gene

  • N-glycosylated.
  • Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; is released both as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein.
  • Glycosylation at Asn50 and Thr316
  • Modification sites at PhosphoSitePlus

Other Protein References for RTN4RL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RTN4RL2 Gene

Domains & Families for RTN4RL2 Gene

Gene Families for RTN4RL2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for RTN4RL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q86UN3

UniProtKB/Swiss-Prot:

R4RL2_HUMAN :
  • Belongs to the Nogo receptor family.
Family:
  • Belongs to the Nogo receptor family.
genes like me logo Genes that share domains with RTN4RL2: view

Function for RTN4RL2 Gene

Molecular function for RTN4RL2 Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).

Phenotypes From GWAS Catalog for RTN4RL2 Gene

Gene Ontology (GO) - Molecular Function for RTN4RL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
GO:0004872 receptor activity IDA 12694398
genes like me logo Genes that share ontologies with RTN4RL2: view
genes like me logo Genes that share phenotypes with RTN4RL2: view

Animal Models for RTN4RL2 Gene

MGI Knock Outs for RTN4RL2:

Animal Model Products

  • Taconic Biosciences Mouse Models for RTN4RL2

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RTN4RL2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RTN4RL2 Gene

Localization for RTN4RL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTN4RL2 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Cell projection, dendrite. Perikaryon. Cell projection, axon. Note=Localized to the surface of neurons, including axons. Detected close to synapses, but is excluded from synapses. {ECO:0000250 UniProtKB:Q7M6Z0}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTN4RL2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RTN4RL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 20463223
genes like me logo Genes that share ontologies with RTN4RL2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RTN4RL2 Gene

Pathways & Interactions for RTN4RL2 Gene

genes like me logo Genes that share pathways with RTN4RL2: view

Gene Ontology (GO) - Biological Process for RTN4RL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IBA --
GO:0006501 C-terminal protein lipidation TAS --
GO:0007166 cell surface receptor signaling pathway ISS --
GO:0010977 negative regulation of neuron projection development ISS --
GO:0019221 cytokine-mediated signaling pathway IBA --
genes like me logo Genes that share ontologies with RTN4RL2: view

No data available for SIGNOR curated interactions for RTN4RL2 Gene

Drugs & Compounds for RTN4RL2 Gene

No Compound Related Data Available

Transcripts for RTN4RL2 Gene

mRNA/cDNA for RTN4RL2 Gene

Unigene Clusters for RTN4RL2 Gene

Reticulon 4 receptor-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RTN4RL2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RTN4RL2 Gene

No ASD Table

Relevant External Links for RTN4RL2 Gene

GeneLoc Exon Structure for
RTN4RL2
ECgene alternative splicing isoforms for
RTN4RL2

Expression for RTN4RL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RTN4RL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RTN4RL2 Gene

This gene is overexpressed in Liver (x8.5), Brain - Cortex (x6.6), Brain - Anterior cingulate cortex (BA24) (x5.7), Brain - Frontal Cortex (BA9) (x5.3), and Thyroid (x4.4).

Protein differential expression in normal tissues from HIPED for RTN4RL2 Gene

This gene is overexpressed in Serum (49.4) and Thyroid (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RTN4RL2 Gene



NURSA nuclear receptor signaling pathways regulating expression of RTN4RL2 Gene:

RTN4RL2

SOURCE GeneReport for Unigene cluster for RTN4RL2 Gene:

Hs.502618

mRNA Expression by UniProt/SwissProt for RTN4RL2 Gene:

Q86UN3-R4RL2_HUMAN
Tissue specificity: Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid.

Evidence on tissue expression from TISSUES for RTN4RL2 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with RTN4RL2: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTN4RL2 Gene

Orthologs for RTN4RL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RTN4RL2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia RTN4RL2 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RTN4RL2 33 34
  • 91.28 (n)
mouse
(Mus musculus)
Mammalia Rtn4rl2 33 16 34
  • 91.25 (n)
rat
(Rattus norvegicus)
Mammalia Rtn4rl2 33
  • 91.17 (n)
chimpanzee
(Pan troglodytes)
Mammalia RTN4RL2 34
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RTN4RL2 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves RTN4RL2 33 34
  • 73.49 (n)
lizard
(Anolis carolinensis)
Reptilia RTN4RL2 34
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rtn4rl2b 33 34
  • 57.08 (n)
rtn4rl2a 34
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1504 34
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lron-12 34
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
OneToMany
Species where no ortholog for RTN4RL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RTN4RL2 Gene

ENSEMBL:
Gene Tree for RTN4RL2 (if available)
TreeFam:
Gene Tree for RTN4RL2 (if available)

Paralogs for RTN4RL2 Gene

Paralogs for RTN4RL2 Gene

(4) SIMAP similar genes for RTN4RL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RTN4RL2: view

Variants for RTN4RL2 Gene

Sequence variations from dbSNP and Humsavar for RTN4RL2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000069728 -- 57,465,051(+) GCACC(A/G/T)ACGCA intron-variant
rs1000248304 -- 57,458,857(+) AGGGG(A/G)CACCC upstream-variant-2KB
rs1000382832 -- 57,476,810(+) CCGGC(G/T)CTGCC reference, missense
rs1000508752 -- 57,465,269(+) GCTCA(C/T)GCCAC intron-variant
rs1000648685 -- 57,460,381(+) GGGGG(A/G)GGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RTN4RL2 Gene

Variant ID Type Subtype PubMed ID
esv2674981 CNV deletion 23128226

Variation tolerance for RTN4RL2 Gene

Residual Variation Intolerance Score: 38.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RTN4RL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RTN4RL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTN4RL2 Gene

Disorders for RTN4RL2 Gene

Relevant External Links for RTN4RL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RTN4RL2

No disorders were found for RTN4RL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RTN4RL2 Gene

Publications for RTN4RL2 Gene

  1. Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. (PMID: 12839991) Barton WA … Nikolov DB (The EMBO journal 2003) 3 4 22 60
  2. Two novel mammalian Nogo receptor homologs differentially expressed in the central and peripheral nervous systems. (PMID: 14664809) Laurén J … Timmusk T (Molecular and cellular neurosciences 2003) 3 4 22 60
  3. Synaptic function for the Nogo-66 receptor NgR1: regulation of dendritic spine morphology and activity-dependent synaptic strength. (PMID: 18337405) Lee H … Giger RJ (The Journal of neuroscience : the official journal of the Society for Neuroscience 2008) 3 22 60
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4 60
  5. Ectodomain shedding of human Nogo-66 receptor homologue-1 by zinc metalloproteinases. (PMID: 15629437) Walmsley AR … Frentzel S (Biochemical and biophysical research communications 2005) 3 4 60

Products for RTN4RL2 Gene

Sources for RTN4RL2 Gene

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