Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RTN4RL2 Gene

Aliases for RTN4RL2 Gene

  • Reticulon 4 Receptor-Like 2 2 3
  • NGRH1 3 4 6
  • NgR2 3 4 6
  • Nogo-66 Receptor-Related Protein 2 3 4
  • Nogo-66 Receptor Homolog 1 3 4
  • Nogo Receptor-Like 3 3 4
  • Reticulon-4 Receptor-Like 2 3
  • NGRL3 4

External Ids for RTN4RL2 Gene

Previous GeneCards Identifiers for RTN4RL2 Gene

  • GC11P057003
  • GC11P056984
  • GC11P057228
  • GC11P053577

Summaries for RTN4RL2 Gene

GeneCards Summary for RTN4RL2 Gene

RTN4RL2 (Reticulon 4 Receptor-Like 2) is a Protein Coding gene. GO annotations related to this gene include receptor activity. An important paralog of this gene is RTN4R.

UniProtKB/Swiss-Prot for RTN4RL2 Gene

  • May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTN4RL2 Gene

Genomics for RTN4RL2 Gene

Regulatory Elements for RTN4RL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RTN4RL2 Gene

57,460,537 bp from pter
57,477,539 bp from pter
17,003 bases
Plus strand

Genomic View for RTN4RL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RTN4RL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTN4RL2 Gene

Proteins for RTN4RL2 Gene

  • Protein details for RTN4RL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Reticulon-4 receptor-like 2
    Protein Accession:
    Secondary Accessions:
    • Q0GGW3
    • Q17RL9
    • Q6X813

    Protein attributes for RTN4RL2 Gene

    420 amino acids
    Molecular mass:
    46106 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RTN4RL2 Gene


neXtProt entry for RTN4RL2 Gene

Proteomics data for RTN4RL2 Gene at MOPED

Post-translational modifications for RTN4RL2 Gene

  • Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; where BRE is released as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein
  • Glycosylation at Asn50 and Thr316
  • Modification sites at PhosphoSitePlus

Other Protein References for RTN4RL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RTN4RL2 Gene

Domains for RTN4RL2 Gene

Suggested Antigen Peptide Sequences for RTN4RL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q86UN3
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
  • Belongs to the Nogo receptor family.
  • Contains 8 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with RTN4RL2: view

No data available for Gene Families for RTN4RL2 Gene

Function for RTN4RL2 Gene

Molecular function for RTN4RL2 Gene

UniProtKB/Swiss-Prot Function: May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.

Gene Ontology (GO) - Molecular Function for RTN4RL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IDA 12694398
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with RTN4RL2: view
genes like me logo Genes that share phenotypes with RTN4RL2: view

Animal Models for RTN4RL2 Gene

MGI Knock Outs for RTN4RL2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RTN4RL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RTN4RL2 Gene

Localization for RTN4RL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTN4RL2 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Note=Localized to the surface of neurons, including axons.

Subcellular locations from

Jensen Localization Image for RTN4RL2 Gene COMPARTMENTS Subcellular localization image for RTN4RL2 gene
Compartment Confidence
plasma membrane 5
extracellular 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RTN4RL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 20463223
GO:0045121 membrane raft IEA --
GO:0046658 anchored component of plasma membrane IDA 12694398
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with RTN4RL2: view

Pathways for RTN4RL2 Gene

SuperPathways for RTN4RL2 Gene

No Data Available

Interacting Proteins for RTN4RL2 Gene

Gene Ontology (GO) - Biological Process for RTN4RL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031103 axon regeneration TAS 14664809
genes like me logo Genes that share ontologies with RTN4RL2: view

No data available for Pathways by source for RTN4RL2 Gene

Transcripts for RTN4RL2 Gene

mRNA/cDNA for RTN4RL2 Gene

Unigene Clusters for RTN4RL2 Gene

Reticulon 4 receptor-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RTN4RL2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTN4RL2 Gene

No ASD Table

Relevant External Links for RTN4RL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RTN4RL2 Gene

mRNA expression in normal human tissues for RTN4RL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RTN4RL2 Gene

This gene is overexpressed in Liver (8.5), Brain - Cortex (6.6), Brain - Anterior cingulate cortex (BA24) (5.7), Brain - Frontal Cortex (BA9) (5.3), and Thyroid (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RTN4RL2 Gene

SOURCE GeneReport for Unigene cluster for RTN4RL2 Gene Hs.502618

mRNA Expression by UniProt/SwissProt for RTN4RL2 Gene

Tissue specificity: Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid.
genes like me logo Genes that share expressions with RTN4RL2: view

In Situ Assay Products

Orthologs for RTN4RL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RTN4RL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RTN4RL2 36
  • 87 (a)
(Bos Taurus)
Mammalia RTN4RL2 35
  • 91.28 (n)
  • 91.28 (a)
RTN4RL2 36
  • 88 (a)
(Canis familiaris)
Mammalia RTN4RL2 36
  • 95 (a)
(Mus musculus)
Mammalia Rtn4rl2 35
  • 91.25 (n)
  • 96.04 (a)
Rtn4rl2 16
Rtn4rl2 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia RTN4RL2 36
  • 76 (a)
(Rattus norvegicus)
Mammalia Rtn4rl2 35
  • 91.17 (n)
  • 95.79 (a)
(Gallus gallus)
Aves RTN4RL2 35
  • 73.49 (n)
  • 70.32 (a)
RTN4RL2 36
  • 58 (a)
(Anolis carolinensis)
Reptilia RTN4RL2 36
  • 68 (a)
(Danio rerio)
Actinopterygii rtn4rl2a 36
  • 43 (a)
rtn4rl2b 35
  • 57.08 (n)
  • 54.25 (a)
rtn4rl2b 36
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1504 36
  • 20 (a)
(Caenorhabditis elegans)
Secernentea lron-12 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
Species with no ortholog for RTN4RL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RTN4RL2 Gene

Gene Tree for RTN4RL2 (if available)
Gene Tree for RTN4RL2 (if available)

Paralogs for RTN4RL2 Gene

Paralogs for RTN4RL2 Gene

Selected SIMAP similar genes for RTN4RL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RTN4RL2: view

Variants for RTN4RL2 Gene

Sequence variations from dbSNP and Humsavar for RTN4RL2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2258835 -- 57,476,115(+) ACCCT(A/G)CCTCA intron-variant
rs2511986 -- 57,464,086(+) AGCAC(C/G)GGGTC intron-variant
rs2584862 -- 57,474,483(+) GGGAG(A/T)GCCAC intron-variant
rs2584863 -- 57,464,817(+) GGGGT(A/G)AGAGA intron-variant
rs2729363 -- 57,459,381(-) GAGCC(G/T)CAGGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RTN4RL2 Gene

Variant ID Type Subtype PubMed ID
esv2674981 CNV Deletion 23128226

Relevant External Links for RTN4RL2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTN4RL2 Gene

Disorders for RTN4RL2 Gene

No disorders were found for RTN4RL2 Gene.

No data available for UniProtKB/Swiss-Prot for RTN4RL2 Gene

Publications for RTN4RL2 Gene

  1. Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. (PMID: 12839991) Barton W.A. … Nikolov D.B. (EMBO J. 2003) 3 4 23
  2. Two novel mammalian nogo receptor homologs differentially expressed in the central and peripheral nervous systems. (PMID: 14664809) Lauren J. … Timmusk T. (Mol. Cell. Neurosci. 2003) 3 4 23
  3. Synaptic function for the Nogo-66 receptor NgR1: regulation of dendritic spine morphology and activity-dependent synaptic strength. (PMID: 18337405) Lee H. … Giger R.J. (J. Neurosci. 2008) 3 23
  4. Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. (PMID: 12694398) Pignot V. … Frentzel S. (J. Neurochem. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RTN4RL2 Gene

Sources for RTN4RL2 Gene

Back to Top