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Aliases for RTN4RL1 Gene

Aliases for RTN4RL1 Gene

  • Reticulon 4 Receptor Like 1 2 3 5
  • Nogo-66 Receptor Homolog 2 2 3 4
  • Nogo-66 Receptor-Related Protein 3 3 4
  • Nogo Receptor-Like 2 3 4
  • NGRH2 3 4
  • NgR3 3 4
  • Reticulon 4 Receptor-Like 1 2
  • Reticulon-4 Receptor-Like 1 3
  • NGRL2 4

External Ids for RTN4RL1 Gene

Previous GeneCards Identifiers for RTN4RL1 Gene

  • GC17M002046
  • GC17M001786
  • GC17M001734
  • GC17M001935
  • GC17M001936
  • GC17M001937
  • GC17M001938

Summaries for RTN4RL1 Gene

GeneCards Summary for RTN4RL1 Gene

RTN4RL1 (Reticulon 4 Receptor Like 1) is a Protein Coding gene. Diseases associated with RTN4RL1 include Retrograde Amnesia. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. GO annotations related to this gene include receptor activity. An important paralog of this gene is RTN4RL2.

UniProtKB/Swiss-Prot for RTN4RL1 Gene

  • May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTN4RL1 Gene

Genomics for RTN4RL1 Gene

Regulatory Elements for RTN4RL1 Gene

Enhancers for RTN4RL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F001994 2.2 Ensembl ENCODE 5.6 +27.6 27612 5.6 ARID4B SIN3A ZNF48 YY1 ZNF121 ZNF263 SP5 REST TSHZ1 ZNF623 ENSG00000262445 DPH1 RPA1 SMYD4 RTN4RL1 LOC105371485
GH17F002010 1 Ensembl ENCODE 8.8 +13.6 13577 1.7 PKNOX1 ZNF133 SIN3A CEBPG ZIC2 YY1 E2F1 ZNF316 GATA3 CTBP1 ENSG00000262445 RTN4RL1 LOC105371485
GH17F002024 0.9 ENCODE 9.1 +0.0 47 1.5 PKNOX1 KLF17 ARID4B ZNF48 RAD21 GLIS2 SCRT2 ZNF143 KLF7 EGR2 RTN4RL1 ENSG00000262869
GH17F002049 1.4 FANTOM5 ENCODE 5.5 -24.7 -24694 2.1 ATF1 SIN3A GLIS2 ELK1 ZNF143 ZNF207 SP3 ZHX2 MXD4 MIER2 RTN4RL1 TSR1 PITPNA SGSM2 SLC43A2 SMG6 MIR132 MIR212
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RTN4RL1 on UCSC Golden Path with GeneCards custom track

Promoters for RTN4RL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001804325 345 2401 PKNOX1 ARID4B SIN3A ZNF48 ZNF121 GLIS2 ZNF143 KLF7 ZNF263 SP3

Genomic Location for RTN4RL1 Gene

1,934,677 bp from pter
2,025,345 bp from pter
90,669 bases
Minus strand

Genomic View for RTN4RL1 Gene

Genes around RTN4RL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTN4RL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTN4RL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTN4RL1 Gene

Proteins for RTN4RL1 Gene

  • Protein details for RTN4RL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Reticulon-4 receptor-like 1
    Protein Accession:
    Secondary Accessions:
    • A1A5E3
    • Q8ND46

    Protein attributes for RTN4RL1 Gene

    441 amino acids
    Molecular mass:
    49065 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RTN4RL1 Gene

Post-translational modifications for RTN4RL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTN4RL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RTN4RL1 Gene

Domains & Families for RTN4RL1 Gene

Suggested Antigen Peptide Sequences for RTN4RL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 LRRCT domain.
  • Belongs to the Nogo receptor family.
  • Contains 8 LRR (leucine-rich) repeats.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
  • Belongs to the Nogo receptor family.
  • Contains 8 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with RTN4RL1: view

No data available for Gene Families for RTN4RL1 Gene

Function for RTN4RL1 Gene

Molecular function for RTN4RL1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.

Gene Ontology (GO) - Molecular Function for RTN4RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
GO:0004872 receptor activity IDA 12694398
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RTN4RL1: view
genes like me logo Genes that share phenotypes with RTN4RL1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RTN4RL1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RTN4RL1 Gene

Localization for RTN4RL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTN4RL1 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Note=Localized to the surface of neurons, including axons.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTN4RL1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RTN4RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IEA --
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 20463223
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RTN4RL1: view

Pathways & Interactions for RTN4RL1 Gene

genes like me logo Genes that share pathways with RTN4RL1: view

Gene Ontology (GO) - Biological Process for RTN4RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IBA --
GO:0019221 cytokine-mediated signaling pathway IBA --
GO:0031103 axon regeneration TAS 14664809
GO:0046426 negative regulation of JAK-STAT cascade IBA --
genes like me logo Genes that share ontologies with RTN4RL1: view

No data available for SIGNOR curated interactions for RTN4RL1 Gene

Transcripts for RTN4RL1 Gene

mRNA/cDNA for RTN4RL1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(43) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RTN4RL1 Gene

Reticulon 4 receptor-like 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTN4RL1 Gene

No ASD Table

Relevant External Links for RTN4RL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RTN4RL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RTN4RL1 Gene

mRNA differential expression in normal tissues according to GTEx for RTN4RL1 Gene

This gene is overexpressed in Brain - Cortex (x5.3) and Brain - Frontal Cortex (BA9) (x4.2).

Protein differential expression in normal tissues from HIPED for RTN4RL1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (49.7) and Seminal vesicle (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RTN4RL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RTN4RL1 Gene:


SOURCE GeneReport for Unigene cluster for RTN4RL1 Gene:


mRNA Expression by UniProt/SwissProt for RTN4RL1 Gene:

Tissue specificity: Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen.
genes like me logo Genes that share expression patterns with RTN4RL1: view

Primer Products

No data available for Protein tissue co-expression partners for RTN4RL1 Gene

Orthologs for RTN4RL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RTN4RL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RTN4RL1 34 35
  • 99.17 (n)
(Bos Taurus)
Mammalia RTN4RL1 34 35
  • 90.93 (n)
(Canis familiaris)
Mammalia RTN4RL1 34 35
  • 89.64 (n)
(Mus musculus)
Mammalia Rtn4rl1 34 16 35
  • 86.32 (n)
(Rattus norvegicus)
Mammalia Rtn4rl1 34
  • 86.32 (n)
(Monodelphis domestica)
Mammalia RTN4RL1 35
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia RTN4RL1 35
  • 70 (a)
(Gallus gallus)
Aves RTN4RL1 34 35
  • 74.94 (n)
(Anolis carolinensis)
Reptilia RTN4RL1 35
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rtn4rl1 34
  • 65.24 (n)
(Danio rerio)
Actinopterygii rtn4rl1b 34 35
  • 62.46 (n)
rtn4rl1a 35
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1504 35
  • 20 (a)
(Caenorhabditis elegans)
Secernentea lron-12 35
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 21 (a)
Species where no ortholog for RTN4RL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RTN4RL1 Gene

Gene Tree for RTN4RL1 (if available)
Gene Tree for RTN4RL1 (if available)

Paralogs for RTN4RL1 Gene

Paralogs for RTN4RL1 Gene

(2) SIMAP similar genes for RTN4RL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RTN4RL1: view

Variants for RTN4RL1 Gene

Sequence variations from dbSNP and Humsavar for RTN4RL1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10438728 -- 1,956,221(+) CCCAG(C/G)GGGGT intron-variant
rs10438741 -- 1,955,184(+) TAGGC(C/G)TTGTG intron-variant
rs10438742 -- 1,956,236(+) GCGAA(C/T)AGGTA intron-variant
rs10531162 -- 2,017,692(+) ACACA(-/CACA)CACAC intron-variant, upstream-variant-2KB
rs10632114 -- 2,021,559(+) TTTTT(-/T)GAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RTN4RL1 Gene

Variant ID Type Subtype PubMed ID
nsv827857 CNV gain 20364138
nsv523761 CNV loss 19592680
nsv112398 CNV insertion 16902084
nsv1056771 CNV gain 25217958
esv3639703 CNV loss 21293372
esv3639702 CNV loss 21293372
esv3582476 CNV loss 25503493
esv3553993 CNV deletion 23714750
esv3553992 CNV deletion 23714750
esv3368806 CNV duplication 20981092
esv33335 CNV loss 17666407
esv2715487 CNV deletion 23290073
esv2715486 CNV deletion 23290073
esv2715484 CNV deletion 23290073
esv2715483 CNV deletion 23290073
esv2674942 CNV deletion 23128226
esv2658213 CNV deletion 23128226
esv2636660 CNV deletion 19546169
esv23541 CNV loss 19812545
esv2272299 CNV deletion 18987734
esv21816 CNV loss 19812545
dgv68n73 CNV deletion 24416366

Variation tolerance for RTN4RL1 Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.70; 46.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RTN4RL1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTN4RL1 Gene

Disorders for RTN4RL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RTN4RL1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retrograde amnesia
  • amnesia, retrograde
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RTN4RL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RTN4RL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RTN4RL1 Gene

Publications for RTN4RL1 Gene

  1. Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. (PMID: 12839991) Barton W.A. … Nikolov D.B. (EMBO J. 2003) 3 4 22 64
  2. Two novel mammalian nogo receptor homologs differentially expressed in the central and peripheral nervous systems. (PMID: 14664809) Lauren J. … Timmusk T. (Mol. Cell. Neurosci. 2003) 3 4 22 64
  3. Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. (PMID: 12694398) Pignot V. … Frentzel S. (J. Neurochem. 2003) 3 4 64
  4. Duplication of 10q22.3-q23.3 encompassing BMPR1A and NGR3 associated with congenital heart disease, microcephaly, and mild intellectual disability. (PMID: 26383923) Tang M. … Tan Z.P. (Am. J. Med. Genet. A 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for RTN4RL1 Gene

Sources for RTN4RL1 Gene

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