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RTN4RL1 Gene

protein-coding   GIFtS: 49
GCID: GC17M001786

Reticulon 4 Receptor-Like 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Reticulon 4 Receptor-Like 11 2     Nogo-66 Receptor-Related Protein 32 3
Nogo-66 Receptor Homolog 21 2 3     Reticulon-4 Receptor-Like 12
NGRH22 3 5     NGRL23
Nogo Receptor-Like 22 3     NGR35
NgR32 3     

External Ids:    HGNC: 213291   Entrez Gene: 1467602   Ensembl: ENSG000001859247   OMIM: 6104615   UniProtKB: Q86UN23   

Export aliases for RTN4RL1 gene to outside databases

Previous GC identifers: GC17M002046 GC17M001734


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RTN4RL1 Gene:
RTN4RL1 (reticulon 4 receptor-like 1) is a protein-coding gene. Diseases associated with RTN4RL1 include cerebritis, and neuronitis. GO annotations related to this gene include receptor activity. An important paralog of this gene is NYX.

UniProtKB/Swiss-Prot: R4RL1_HUMAN, Q86UN2
Function: May play a role in regulating axonal regeneration and plasticity in the adult central nervous system




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the RTN4RL1 gene promoter:
         c-Fos   Max1   NF-1   NCX/Ncx   SREBP-1c   SREBP-1b   GATA-2   SREBP-1a   Chx10   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRTN4RL1 promoter sequence
   Search Chromatin IP Primers for RTN4RL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RTN4RL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

RTN4RL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTN4RL1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M001786:  view genomic region     (about GC identifiers)

Start:
1,837,971 bp from pter      End:
1,928,639 bp from pter
Size:
90,669 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: R4RL1_HUMAN, Q86UN2 (See protein sequence)
Recommended Name: Reticulon-4 receptor-like 1 precursor  
Size: 441 amino acids; 49065 Da
Secondary accessions: A1A5E3 Q8ND46

Explore the universe of human proteins at neXtProt for RTN4RL1: NX_Q86UN2

Explore proteomics data for RTN4RL1 at MOPED


See RTN4RL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_848663.1  
ENSEMBL proteins: 
 ENSP00000330631  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR000483 Cys-rich_flank_reg_C
 IPR000372 LRR-contain_N
 IPR001611 Leu-rich_rpt
 IPR003591 Leu-rich_rpt_typical-subtyp

Graphical View of Domain Structure for InterPro Entry Q86UN2

ProtoNet protein and cluster: Q86UN2

2 Blocks protein domains:
IPB000372 Cysteine-rich flanking region
IPB000483 Cysteine-rich flanking region


UniProtKB/Swiss-Prot: R4RL1_HUMAN, Q86UN2
Similarity: Belongs to the Nogo receptor family
Similarity: Contains 8 LRR (leucine-rich) repeats
Similarity: Contains 1 LRRCT domain
Similarity: Contains 1 LRRNT domain


RTN4RL1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: R4RL1_HUMAN, Q86UN2
Function: May play a role in regulating axonal regeneration and plasticity in the adult central nervous system

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004872receptor activity IDA12694398
GO:0005515protein binding ----
     
RTN4RL1 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for RTN4RL1:
 Decreased G3BP1 protein expres  Decreased Salmonella enterica  

     3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rtn4rl1):
 endocrine/exocrine gland  liver/biliary system  nervous system 

RTN4RL1 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RTN4RL1
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   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RTN4RL1

miRNA
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Block miRNA regulation of human, mouse, rat RTN4RL1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate RTN4RL1 (see all 26):
hsa-miR-448 hsa-miR-200a hsa-miR-4305 hsa-miR-374a hsa-miR-500a hsa-miR-340 hsa-miR-410 hsa-miR-449a
SwitchGear 3'UTR luciferase reporter plasmidRTN4RL1 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat RTN4RL1

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Sino Biological Human cDNA Clone for RTN4RL1
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTN4RL1

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
R4RL1_HUMAN, Q86UN2: Cell membrane; Lipid-anchor, GPI-anchor. Note=Localized to the surface of neurons, including
axons
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5
extracellular3
endoplasmic reticulum1
golgi apparatus1
lysosome1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0009897external side of plasma membrane IEA--
GO:0009986cell surface IDA--
GO:0045121membrane raft IEA--
GO:0046658anchored component of plasma membrane IDA12694398

RTN4RL1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RTN4RL1
Interactions:

    Search GeneGlobe Interaction Network for RTN4RL1

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for RTN4RL1 (Q86UN23 ENSP000003306314) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
OMGP235153, ENSP000002472714I2D: score=1 STRING: ENSP00000247271
LRRTM1ENSP000002950574STRING: ENSP00000295057
CAB39ENSP000002584184STRING: ENSP00000258418
CAB39LENSP000002616694STRING: ENSP00000261669
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0031103axon regeneration TAS14664809

RTN4RL1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for RTN4RL1 (R4RL1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for RTN4RL1 gene: 
NM_178568.2  

Unigene Cluster for RTN4RL1:

Reticulon 4 receptor-like 1
Hs.22917  [show with all ESTs]
Unigene Representative Sequence: NM_178568
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000331238(uc002ftp.3)
miRNA
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Selected qRT-PCR Assays for microRNAs that regulate RTN4RL1 (see all 26):
hsa-miR-448 hsa-miR-200a hsa-miR-4305 hsa-miR-374a hsa-miR-500a hsa-miR-340 hsa-miR-410 hsa-miR-449a
SwitchGear 3'UTR luciferase reporter plasmidRTN4RL1 3' UTR sequence
Inhib. RNA
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Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RTN4RL1
  QuantiTect SYBR Green Assays in human, mouse, rat RTN4RL1
  QuantiFast Probe-based Assays in human, mouse, rat RTN4RL1

Additional mRNA sequence: 

AF532859.1 AL834409.1 AY250219.1 BC023311.1 BC128608.1 

1 DOTS entry:

DT.111911 

Selected AceView cDNA sequences (see all 43):

R20190 BU618906 BM826920 BM692581 BQ445827 CA429077 NM_178568 AI680692 
BM718025 AF532859 BM663803 BX091346 BQ771530 BM976284 AI693887 CA454639 
AA453794 AI278851 AY250219 BM680479 BK001305 BU740371 BM709737 BC023311 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RTN4RL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
RTN4RL1 Expression
About this image


RTN4RL1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Brain (Nervous System)    fully expand to see all 16 entries
         Thalamus
         Septum   
 
 Testis (Reproductive System)    fully expand to see all 2 entries
         Pre-Sertoli Cells Testis Cord
 
 Neurons
         Type1 Off Cone Bipolar Cells Inner Nuclear Layer
 
 Eye (Sensory Organs)
         Type1 Off Cone Bipolar Cells Inner Nuclear Layer
RTN4RL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RTN4RL1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.22917

UniProtKB/Swiss-Prot: R4RL1_HUMAN, Q86UN2
Tissue specificity: Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland,
placenta, salivary gland, skeletal muscle and spleen

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4RL1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for RTN4RL1 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rtn4rl11 , 5 reticulon 4 receptor-like 11, 5 86.32(n)1
88.66(a)1
  11 (45.76 cM)5
2378471  NM_177708.51  NP_808376.11 
 751937835 
chicken
(Gallus gallus)
Aves RTN4RL11 reticulon 4 receptor-like 1 74.94(n)
74.94(a)
  427828  XM_425402.4  XP_425402.4 
lizard
(Anolis carolinensis)
Reptilia RTN4RL16
reticulon 4 receptor-like 1
62(a)
1 ↔ 1
GL343393.1(4196-5458)
tropical clawed frog
(Xenopus tropicalis)
Amphibia rtn4rl11 reticulon 4 receptor-like 1 65.24(n)
71.86(a)
  779975  NM_001079052.1  NP_001072520.1 
zebrafish
(Danio rerio)
Actinopterygii rtn4rl1b1 reticulon 4 receptor-like 1b 62.46(n)
62.12(a)
  403308  NM_203480.1  NP_982347.1 
fruit fly
(Drosophila melanogaster)
Insecta CG15046
--
20(a)
1 → many
X(20181336-20186734)
worm
(Caenorhabditis elegans)
Secernentea lron-126
Protein LRON-12 (lron-12) mRNA, complete cds
16(a)
1 → many
III(12114564-12118470) WBGene00013542


ENSEMBL Gene Tree for RTN4RL1 (if available)
TreeFam Gene Tree for RTN4RL1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RTN4RL1 gene
NYX2  LRRC532  RTN4R2  LRRC702  RTN4RL22  
2 SIMAP similar genes for RTN4RL1 using alignment to 1 protein entry:     R4RL1_HUMAN:
RTN4RL2    RTN4R

RTN4RL1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RTN4RL1 (see all 2139)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs725204671,2
C--1762151(+) TTCAA-/GTGA  
        
TTCTC
1 -- int10--------
rs1505017051,2
C--1828052(+) GAGACA/GTGTGC 1 -- int10--------
rs80805491,2
C,F,A,H--1828085(+) TGTCCG/TGGTGG 1 -- int112Minor allele frequency- T:0.26NA EA WA CSA 732
rs739761411,2
C--1828153(+) CGCCCG/ATCCCC 1 -- int11Minor allele frequency- A:0.50WA 2
rs80805781,2
C,F,A,H--1828166(+) CAGCCG/ACCTGC 1 -- int18Minor allele frequency- A:0.29NA WA CSA EA 370
rs1911722281,2
--1828173(+) CTGCCA/GGGCGC 1 -- int10--------
rs1830764711,2
--1828256(+) TCCTCC/TGGGGA 1 -- int10--------
rs1496888231,2
--1828292(+) GGGCAG/TTCAGA 1 -- int10--------
rs1870715801,2
--1828316(+) ATCATC/GATCTG 1 -- int10--------
rs1903862601,2
--1828324(+) CTGTGC/TGGGCA 1 -- int10--------

HapMap Linkage Disequilibrium report for RTN4RL1 (1837971 - 1928639 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for RTN4RL1 (see all 17):    About this table    
Variant IDTypeSubtypePubMed ID
esv2272299CNV Deletion18987734
esv2715484CNV Deletion23290073
esv2715487CNV Deletion23290073
esv2715483CNV Deletion23290073
esv2636660CNV Deletion19546169
esv2715486CNV Deletion23290073
esv2674942CNV Deletion23128226
esv2658213CNV Deletion23128226
nsv112398CNV Insertion16902084
nsv907523CNV Loss21882294

Human Gene Mutation Database (HGMD): RTN4RL1
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing RTN4RL1
DNA2.0 Custom Variant and Variant Library Synthesis for RTN4RL1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 610461    OMIM disorders: --

2 diseases for RTN4RL1:    
About MalaCards
cerebritis    neuronitis


RTN4RL1 for disorders           About GeneDecksing


Export disorders for RTN4RL1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RTN4RL1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with RTN4RL1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. (PubMed id 12839991)1, 2, 9 Barton W.A.... Nikolov D.B. (EMBO J. 2003)
  2. Two novel mammalian nogo receptor homologs differentially expressed in the central and peripheral nervous systems. (PubMed id 14664809)1, 2, 9 Lauren J.... Timmusk T. (Mol. Cell. Neurosci. 2003)
  3. Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. (PubMed id 12694398)1, 2 Pignot V.... Frentzel S. (J. Neurochem. 2003)
  4. Nogo receptor 3, a paralog of Nogo-66 receptor 1 (NgR1), may function as a NgR1 co-receptor for Nogo-66. (PubMed id 22133682)1 Zhang L....Zhang J. (J Genet Genomics 2011)
  5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. (PubMed id 12068310)1 Wang K.C....He Z. (Nature 2002)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 146760 HGNC: 21329 AceView: RTN4RL1 Ensembl:ENSG00000185924 euGenes: HUgn146760
ECgene: RTN4RL1 H-InvDB: RTN4RL1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RTN4RL1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RTN4RL1 gene:
Search GeneIP for patents involving RTN4RL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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