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Aliases for RTN4RL1 Gene

Aliases for RTN4RL1 Gene

  • Reticulon 4 Receptor-Like 1 2 3
  • Nogo-66 Receptor Homolog 2 2 3 4
  • NGRH2 3 4 6
  • NgR3 3 4 6
  • Nogo-66 Receptor-Related Protein 3 3 4
  • Nogo Receptor-Like 2 3 4
  • Reticulon-4 Receptor-Like 1 3
  • NGRL2 4

External Ids for RTN4RL1 Gene

Previous GeneCards Identifiers for RTN4RL1 Gene

  • GC17M002046
  • GC17M001786
  • GC17M001734

Summaries for RTN4RL1 Gene

GeneCards Summary for RTN4RL1 Gene

RTN4RL1 (Reticulon 4 Receptor-Like 1) is a Protein Coding gene. GO annotations related to this gene include receptor activity. An important paralog of this gene is RTN4R.

UniProtKB/Swiss-Prot for RTN4RL1 Gene

  • May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTN4RL1 Gene

Genomics for RTN4RL1 Gene

Regulatory Elements for RTN4RL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RTN4RL1 Gene

1,934,677 bp from pter
2,025,345 bp from pter
90,669 bases
Minus strand

Genomic View for RTN4RL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RTN4RL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTN4RL1 Gene

Proteins for RTN4RL1 Gene

  • Protein details for RTN4RL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Reticulon-4 receptor-like 1
    Protein Accession:
    Secondary Accessions:
    • A1A5E3
    • Q8ND46

    Protein attributes for RTN4RL1 Gene

    441 amino acids
    Molecular mass:
    49065 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RTN4RL1 Gene

Proteomics data for RTN4RL1 Gene at MOPED

Post-translational modifications for RTN4RL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTN4RL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RTN4RL1 Gene

Domains for RTN4RL1 Gene

Suggested Antigen Peptide Sequences for RTN4RL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q86UN2
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
  • Belongs to the Nogo receptor family.
  • Contains 8 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with RTN4RL1: view

No data available for Gene Families for RTN4RL1 Gene

Function for RTN4RL1 Gene

Molecular function for RTN4RL1 Gene

UniProtKB/Swiss-Prot Function: May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.

Gene Ontology (GO) - Molecular Function for RTN4RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IDA 12694398
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RTN4RL1: view
genes like me logo Genes that share phenotypes with RTN4RL1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RTN4RL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RTN4RL1 Gene

Localization for RTN4RL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTN4RL1 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Note=Localized to the surface of neurons, including axons.

Subcellular locations from

Jensen Localization Image for RTN4RL1 Gene COMPARTMENTS Subcellular localization image for RTN4RL1 gene
Compartment Confidence
plasma membrane 5
extracellular 3
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for RTN4RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 20463223
GO:0045121 membrane raft IEA --
GO:0046658 anchored component of plasma membrane IDA 12694398
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with RTN4RL1: view

Pathways for RTN4RL1 Gene

SuperPathways for RTN4RL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RTN4RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031103 axon regeneration TAS 14664809
genes like me logo Genes that share ontologies with RTN4RL1: view

No data available for Pathways by source for RTN4RL1 Gene

Transcripts for RTN4RL1 Gene

mRNA/cDNA for RTN4RL1 Gene

(43) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RTN4RL1 Gene

Reticulon 4 receptor-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RTN4RL1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RTN4RL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTN4RL1 Gene

No ASD Table

Relevant External Links for RTN4RL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RTN4RL1 Gene

mRNA expression in normal human tissues for RTN4RL1 Gene

mRNA differential expression in normal tissues according to GTEx for RTN4RL1 Gene

This gene is overexpressed in Brain - Cortex (5.3) and Brain - Frontal Cortex (BA9) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RTN4RL1 Gene

SOURCE GeneReport for Unigene cluster for RTN4RL1 Gene Hs.22917

mRNA Expression by UniProt/SwissProt for RTN4RL1 Gene

Tissue specificity: Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen.
genes like me logo Genes that share expressions with RTN4RL1: view

In Situ Assay Products

Orthologs for RTN4RL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RTN4RL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RTN4RL1 35
  • 99.17 (n)
  • 98.87 (a)
RTN4RL1 36
  • 99 (a)
(Bos Taurus)
Mammalia RTN4RL1 35
  • 90.93 (n)
  • 90.48 (a)
RTN4RL1 36
  • 88 (a)
(Canis familiaris)
Mammalia RTN4RL1 35
  • 89.64 (n)
  • 90.25 (a)
RTN4RL1 36
  • 89 (a)
(Mus musculus)
Mammalia Rtn4rl1 35
  • 86.32 (n)
  • 88.66 (a)
Rtn4rl1 16
Rtn4rl1 36
  • 88 (a)
(Monodelphis domestica)
Mammalia RTN4RL1 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia RTN4RL1 36
  • 70 (a)
(Rattus norvegicus)
Mammalia Rtn4rl1 35
  • 86.32 (n)
  • 87.76 (a)
(Gallus gallus)
Aves RTN4RL1 35
  • 74.94 (n)
  • 74.94 (a)
RTN4RL1 36
  • 71 (a)
(Anolis carolinensis)
Reptilia RTN4RL1 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rtn4rl1 35
  • 65.24 (n)
  • 71.86 (a)
(Danio rerio)
Actinopterygii rtn4rl1a 36
  • 59 (a)
rtn4rl1b 35
  • 62.46 (n)
  • 62.12 (a)
rtn4rl1b 36
  • 54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1504 36
  • 20 (a)
(Caenorhabditis elegans)
Secernentea lron-12 36
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
Species with no ortholog for RTN4RL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RTN4RL1 Gene

Gene Tree for RTN4RL1 (if available)
Gene Tree for RTN4RL1 (if available)

Paralogs for RTN4RL1 Gene

Paralogs for RTN4RL1 Gene

Selected SIMAP similar genes for RTN4RL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RTN4RL1: view

Variants for RTN4RL1 Gene

Sequence variations from dbSNP and Humsavar for RTN4RL1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs9818 -- 1,935,058(+) TGTCC(C/T)ACACA utr-variant-3-prime
rs1137770 -- 2,019,326(+) GTCAT(C/G)TCCTC intron-variant
rs3803804 -- 2,019,762(+) AGGAA(C/T)GAGGG intron-variant
rs3803805 -- 2,019,848(+) TTCCC(A/G)TGCTG intron-variant
rs3923783 -- 1,939,895(+) CTTTG(A/C)TTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RTN4RL1 Gene

Variant ID Type Subtype PubMed ID
esv33335 CNV Loss 17666407
nsv907522 CNV Loss 21882294
nsv907523 CNV Loss 21882294
dgv3034n71 CNV Loss 21882294
nsv523761 CNV Loss 19592680
esv2715483 CNV Deletion 23290073
nsv827857 CNV Gain 20364138
nsv112398 CNV Insertion 16902084
esv2636660 CNV Deletion 19546169
esv2715484 CNV Deletion 23290073
esv2674942 CNV Deletion 23128226
esv23541 CNV Loss 19812545
esv2272299 CNV Deletion 18987734
esv2715486 CNV Deletion 23290073
esv2658213 CNV Deletion 23128226
esv2715487 CNV Deletion 23290073
esv21816 CNV Loss 19812545

Relevant External Links for RTN4RL1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTN4RL1 Gene

Disorders for RTN4RL1 Gene

No disorders were found for RTN4RL1 Gene.

No data available for UniProtKB/Swiss-Prot for RTN4RL1 Gene

Publications for RTN4RL1 Gene

  1. Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. (PMID: 12839991) Barton W.A. … Nikolov D.B. (EMBO J. 2003) 3 4 23
  2. Two novel mammalian nogo receptor homologs differentially expressed in the central and peripheral nervous systems. (PMID: 14664809) Lauren J. … Timmusk T. (Mol. Cell. Neurosci. 2003) 3 4 23
  3. Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. (PMID: 12694398) Pignot V. … Frentzel S. (J. Neurochem. 2003) 3 4
  4. LGI1 is a Nogo receptor 1 ligand that antagonizes myelin-based growth inhibition. (PMID: 20463223) Thomas R. … Barker P.A. (J. Neurosci. 2010) 3
  5. Nogo receptor 3, a paralog of Nogo-66 receptor 1 (NgR1), may function as a NgR1 co-receptor for Nogo-66. (PMID: 22133682) Zhang L. … Zhang J. (J Genet Genomics 2011) 3

Products for RTN4RL1 Gene

Sources for RTN4RL1 Gene

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