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Aliases for RTN4RL1 Gene

Aliases for RTN4RL1 Gene

  • Reticulon 4 Receptor Like 1 2 3
  • Reticulon 4 Receptor-Like 1 2 3 5
  • Nogo-66 Receptor Homolog 2 2 3 4
  • Nogo-66 Receptor-Related Protein 3 3 4
  • Nogo Receptor-Like 2 3 4
  • NGRH2 3 4
  • NgR3 3 4
  • NGRL2 4

External Ids for RTN4RL1 Gene

Previous GeneCards Identifiers for RTN4RL1 Gene

  • GC17M002046
  • GC17M001786
  • GC17M001734
  • GC17M001935
  • GC17M001936

Summaries for RTN4RL1 Gene

GeneCards Summary for RTN4RL1 Gene

RTN4RL1 (Reticulon 4 Receptor Like 1) is a Protein Coding gene. Diseases associated with RTN4RL1 include Retrograde Amnesia. GO annotations related to this gene include receptor activity. An important paralog of this gene is TPBGL.

UniProtKB/Swiss-Prot for RTN4RL1 Gene

  • May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTN4RL1 Gene

Genomics for RTN4RL1 Gene

Regulatory Elements for RTN4RL1 Gene

Enhancers for RTN4RL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RTN4RL1 on UCSC Golden Path with GeneCards custom track

Promoters for RTN4RL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RTN4RL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RTN4RL1 Gene

Chromosome:
17
Start:
1,934,677 bp from pter
End:
2,025,345 bp from pter
Size:
90,669 bases
Orientation:
Minus strand

Genomic View for RTN4RL1 Gene

Genes around RTN4RL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTN4RL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTN4RL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTN4RL1 Gene

Proteins for RTN4RL1 Gene

  • Protein details for RTN4RL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UN2-R4RL1_HUMAN
    Recommended name:
    Reticulon-4 receptor-like 1
    Protein Accession:
    Q86UN2
    Secondary Accessions:
    • A1A5E3
    • Q8ND46

    Protein attributes for RTN4RL1 Gene

    Size:
    441 amino acids
    Molecular mass:
    49065 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RTN4RL1 Gene

Proteomics data for RTN4RL1 Gene at MOPED

Post-translational modifications for RTN4RL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTN4RL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RTN4RL1 Gene

Domains & Families for RTN4RL1 Gene

Suggested Antigen Peptide Sequences for RTN4RL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UN2

UniProtKB/Swiss-Prot:

R4RL1_HUMAN :
  • Contains 1 LRRCT domain.
  • Belongs to the Nogo receptor family.
  • Contains 8 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Family:
  • Belongs to the Nogo receptor family.
Similarity:
  • Contains 8 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with RTN4RL1: view

No data available for Gene Families for RTN4RL1 Gene

Function for RTN4RL1 Gene

Molecular function for RTN4RL1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.

Gene Ontology (GO) - Molecular Function for RTN4RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
genes like me logo Genes that share ontologies with RTN4RL1: view
genes like me logo Genes that share phenotypes with RTN4RL1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RTN4RL1

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RTN4RL1 Gene

Localization for RTN4RL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTN4RL1 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Note=Localized to the surface of neurons, including axons.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RTN4RL1 Gene COMPARTMENTS Subcellular localization image for RTN4RL1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RTN4RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0009897 external side of plasma membrane IEA --
GO:0045121 membrane raft IEA --
genes like me logo Genes that share ontologies with RTN4RL1: view

Pathways & Interactions for RTN4RL1 Gene

SuperPathways for RTN4RL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RTN4RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031103 axon regeneration TAS 14664809
GO:1904030 negative regulation of cyclin-dependent protein kinase activity IBA --
genes like me logo Genes that share ontologies with RTN4RL1: view

No data available for Pathways by source and SIGNOR curated interactions for RTN4RL1 Gene

Drugs & Compounds for RTN4RL1 Gene

No Compound Related Data Available

Transcripts for RTN4RL1 Gene

mRNA/cDNA for RTN4RL1 Gene

Unigene Clusters for RTN4RL1 Gene

Reticulon 4 receptor-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RTN4RL1 Gene

No ASD Table

Relevant External Links for RTN4RL1 Gene

GeneLoc Exon Structure for
RTN4RL1
ECgene alternative splicing isoforms for
RTN4RL1

Expression for RTN4RL1 Gene

mRNA expression in normal human tissues for RTN4RL1 Gene

mRNA differential expression in normal tissues according to GTEx for RTN4RL1 Gene

This gene is overexpressed in Brain - Cortex (x5.3) and Brain - Frontal Cortex (BA9) (x4.2).

Protein differential expression in normal tissues from HIPED for RTN4RL1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (49.7) and Seminal vesicle (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RTN4RL1 Gene



SOURCE GeneReport for Unigene cluster for RTN4RL1 Gene Hs.22917

mRNA Expression by UniProt/SwissProt for RTN4RL1 Gene

Q86UN2-R4RL1_HUMAN
Tissue specificity: Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen.
genes like me logo Genes that share expression patterns with RTN4RL1: view

Primer Products

No data available for Protein tissue co-expression partners for RTN4RL1 Gene

Orthologs for RTN4RL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RTN4RL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RTN4RL1 35
  • 90.93 (n)
  • 90.48 (a)
RTN4RL1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RTN4RL1 35
  • 89.64 (n)
  • 90.25 (a)
RTN4RL1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rtn4rl1 35
  • 86.32 (n)
  • 88.66 (a)
Rtn4rl1 16
Rtn4rl1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RTN4RL1 35
  • 99.17 (n)
  • 98.87 (a)
RTN4RL1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rtn4rl1 35
  • 86.32 (n)
  • 87.76 (a)
oppossum
(Monodelphis domestica)
Mammalia RTN4RL1 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RTN4RL1 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves RTN4RL1 35
  • 74.94 (n)
  • 74.94 (a)
RTN4RL1 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RTN4RL1 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rtn4rl1 35
  • 65.24 (n)
  • 71.86 (a)
zebrafish
(Danio rerio)
Actinopterygii rtn4rl1b 35
  • 62.46 (n)
  • 62.12 (a)
rtn4rl1a 36
  • 59 (a)
OneToMany
rtn4rl1b 36
  • 54 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1504 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lron-12 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToMany
Species with no ortholog for RTN4RL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RTN4RL1 Gene

ENSEMBL:
Gene Tree for RTN4RL1 (if available)
TreeFam:
Gene Tree for RTN4RL1 (if available)

Paralogs for RTN4RL1 Gene

Paralogs for RTN4RL1 Gene

(2) SIMAP similar genes for RTN4RL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RTN4RL1: view

Variants for RTN4RL1 Gene

Sequence variations from dbSNP and Humsavar for RTN4RL1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs9818 -- 1,935,058(+) TGTCC(C/T)ACACA utr-variant-3-prime
rs4073661 -- 1,942,656(-) ACACA(A/G)CACAG intron-variant
rs4073992 -- 1,942,168(+) GGGGG(A/T)GTCCC intron-variant
rs4077911 -- 1,939,244(-) TCCCA(A/G)GTAGC intron-variant
rs4077912 -- 1,939,213(-) ACCAC(A/G)CCCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RTN4RL1 Gene

Variant ID Type Subtype PubMed ID
esv33335 CNV Loss 17666407
nsv907522 CNV Loss 21882294
nsv907523 CNV Loss 21882294
dgv3034n71 CNV Loss 21882294
nsv523761 CNV Loss 19592680
esv2715483 CNV Deletion 23290073
nsv827857 CNV Gain 20364138
nsv112398 CNV Insertion 16902084
esv2636660 CNV Deletion 19546169
esv2715484 CNV Deletion 23290073
esv2674942 CNV Deletion 23128226
esv23541 CNV Loss 19812545
esv2272299 CNV Deletion 18987734
esv2715486 CNV Deletion 23290073
esv2658213 CNV Deletion 23128226
esv2715487 CNV Deletion 23290073
esv21816 CNV Loss 19812545

Variation tolerance for RTN4RL1 Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.70; 46.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RTN4RL1 Gene

Human Gene Mutation Database (HGMD)
RTN4RL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTN4RL1 Gene

Disorders for RTN4RL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RTN4RL1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retrograde amnesia
  • amnesia, retrograde
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RTN4RL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RTN4RL1
genes like me logo Genes that share disorders with RTN4RL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RTN4RL1 Gene

Publications for RTN4RL1 Gene

  1. Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. (PMID: 12839991) Barton W.A. … Nikolov D.B. (EMBO J. 2003) 3 4 23 67
  2. Two novel mammalian nogo receptor homologs differentially expressed in the central and peripheral nervous systems. (PMID: 14664809) Lauren J. … Timmusk T. (Mol. Cell. Neurosci. 2003) 3 23
  3. Novel Cul3 binding proteins function to remodel E3 ligase complexes. (PMID: 25011449) Wimuttisuk W. … Singer J.D. (BMC Cell Biol. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3

Products for RTN4RL1 Gene

Sources for RTN4RL1 Gene

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