Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RTN4R Gene

protein-coding   GIFtS: 61
GCID: GC22M020234

reticulon 4 receptor

 Explore 13 diseases affiliated with
RTN4R via our new
 Human Malady Compendium 
Biological research products
for RTN4R
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Reticulon 4 Receptor1 2     NGR2
NOGOR1 2 3 5     UNQ330/PRO5262
Nogo Receptor2 3     Reticulon-4 Receptor2
Nogo-66 Receptor2 3     NgR3

External Ids:    HGNC: 186011   Entrez Gene: 650782   Ensembl: ENSG000000406087   OMIM: 6055665   UniProtKB: Q9BZR63   

Export aliases for RTN4R gene to outside databases

Previous GC identifers: GC22M017169 GC22M018603 GC22M003848


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RTN4R:
This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein.
This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity
in the adult central nervous system. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RTN4R_HUMAN, Q9BZR6
Function: Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal
regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1 in regulating
neuronal precursor cell motility during cortical development (By similarity)

Gene Wiki entry for RTN4R (Reticulon 4 receptor)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011519.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RTN4R gene promoter:
         STAT5B   STAT1   STAT4   STAT6   STAT1beta   STAT5A   STAT1alpha   AREB6   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRTN4R promoter sequence
   Search SABiosciences Chromatin IP Primers for RTN4R

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RTN4R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11

RTN4R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTN4R gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M020234:  view genomic region     (about GC identifiers)

Start:
20,228,938 bp from pter      End:
20,270,769 bp from pter
Size:
41,832 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RTN4R_HUMAN, Q9BZR6 (See protein sequence)
Recommended Name: Reticulon-4 receptor precursor  
Size: 473 amino acids; 50708 Da
Subunit: Homomultimer. Interacts with LINGO1. Interacts with KIAA0319L
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
2 PDB 3D structures from and Proteopedia for RTN4R:
1OZN (3D)        1P8T (3D)    
Secondary accessions: D3DX28

Explore the universe of human proteins at neXtProt for RTN4R: NX_Q9BZR6

RTN4R Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_075380.1  
ENSEMBL proteins: 
 ENSP00000396872   ENSP00000043402   ENSP00000403535  
Reactome Protein details: Q9BZR6
Human Recombinant Protein Products: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for RTN4R (Nogo Receptor/NgR)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate: RTN4R
OriGene Custom Protein Services for RTN4R 
GenScript Custom Purified and Recombinant Proteins Services for RTN4R
Novus Biologicals RTN4R Protein
Novus Biologicals RTN4R Lysates
Sino Biological Recombinant Protein for RTN4R
Browse ProSpec Recombinant Proteins
Uscn Proteins for RTN4R

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005783endoplasmic reticulum IDA--
GO:0005886plasma membrane TAS--
GO:0009986cell surface IDA--
GO:0016020membrane NAS--
GO:0031225anchored to membrane IEA--


RTN4R for ontologies           About GeneDecksing



RTN4R Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for RTN4R (Nogo Receptor/NgR)
OriGene Antibodies: RTN4R
OriGene Custom Antibody Services for RTN4R 
GenScript Custom Superior Antibodies Services for RTN4R
Novus Biologicals RTN4R Antibodies
Search for Antibodies for RTN4R at Abcam  
Uscn Antibodies for RTN4R
ThermoFisher Antibodies for RTN4R

Assay Products for RTN4R: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Immunoassay Development
Browse OriGene Fluorogenic Cell Assay Kits
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for RTN4R
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for RTN4R


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RTN4R for domains           About GeneDecksing

4 InterPro domains/families:
 IPR000483 Cys-rich_flank_reg_C
 IPR000372 LRR-contain_N
 IPR001611 Leu-rich_rpt
 IPR003591 Leu-rich_rpt_typical-subtyp

Graphical View of Domain Structure for InterPro Entry Q9BZR6

ProtoNet protein and cluster: Q9BZR6

3 Blocks protein families:
IPB000372 Cysteine-rich flanking region
IPB000483 Cysteine-rich flanking region
IPB001611 Leucine-rich repeat signature


UniProtKB/Swiss-Prot: RTN4R_HUMAN, Q9BZR6
Similarity: Belongs to the Nogo receptor family
Similarity: Contains 8 LRR (leucine-rich) repeats
Similarity: Contains 1 LRRCT domain
Similarity: Contains 1 LRRNT domain


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: RTN4R_HUMAN, Q9BZR6
Function: Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal
regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1 in regulating
neuronal precursor cell motility during cortical development (By similarity)

miRNA
Products:
    
OriGene 3'-UTR Clone: RTN4R
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RTN4R
8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate RTN4R (see all 18):
hsa-miR-30c hsa-miR-875-3p hsa-miR-3607-3p hsa-miR-10b hsa-miR-30d hsa-miR-30a hsa-miR-3658 hsa-miR-3662
SwitchGear 3'UTR luciferase reporter plasmidRTN4R 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RTN4R (see all 7)
OriGene shRNA RFP: RTN4R
OriGene siRNA: RTN4R
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RTN4R

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for RTN4R

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RTN4R (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RTN4R
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: RTN4R (NM_023004)
Sino Biological Human cDNA Clone for RTN4R
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RTN4R
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTN4R 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for RTN4R
Search LifeMap BioReagents cell lines for RTN4R

In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4R

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004872receptor activity NAS11201742
GO:0005515protein binding IPI--


RTN4R for ontologies           About GeneDecksing


1 GenomeRNAi human phenotype for RTN4R:
 Increased gamma-H2AX phosphory 

Animal Models:
     Mouse knock-outs for RTN4R: Rtn4rtm1Stmr Rtn4rtm1Gogo Rtn4rtm1.1Pado Rtn4rtm1Matl
     5 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Rtn4r):
 behavior/neurological  cellular  homeostasis/metabolism  nervous system  no phenotypic analysis 

RTN4R for phenotypes           About GeneDecksing


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Axonal growth inhibition (RHOA activation)
Axonal growth inhibition (RHOA activation)1.00
p75NTR regulates axonogenesis0.90
2Development MAG-dependent inhibition of neurite outgrowth
Development MAG-dependent inhibition of neurite outgrowth1.00
Development_MAG-dependent inhibition of neurite outgrowth0.87
3NgR-p75(NTR)-Mediated Signaling
NgR-p75(NTR)-Mediated Signaling1.00
4Guidance Cues and Growth Cone Motility
Guidance Cues and Growth Cone Motility1.00
5p75(NTR)-mediated signaling
p75(NTR)-mediated signaling1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for RTN4R
    Development MAG-dependent inhibition of neurite outgrowth

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RTN4R
    Guidance Cues and Growth Cone Motility
NgR-p75(NTR)-Mediated Signaling

1 GeneGo (Thomson Reuters) Pathway for RTN4R
    Development MAG-dependent inhibition of neurite outgrowth

1 BioSystems Pathway for RTN4R 
    p75(NTR)-mediated signaling

5        Reactome Pathways for RTN4R
    Axonal growth inhibition (RHOA activation)
Signal Transduction
p75NTR regulates axonogenesis
Signalling by NGF
p75 NTR receptor-mediated signalling



RTN4R for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RTN4R

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/11 Interacting proteins for RTN4R (Q9BZR61, 3 ENSP000000434024) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
InteractantInteraction Details
GeneCardExternal ID(s)
NGFRP081383, ENSP000001722294I2D: score=4 STRING: ENSP00000172229
RTN4Q9NQC33, ENSP000003378384I2D: score=3 STRING: ENSP00000337838
LINGO1Q96FE53, ENSP000003474514I2D: score=2 STRING: ENSP00000347451
OMGP235153, ENSP000002472714I2D: score=1 STRING: ENSP00000247271
RTN4IP1Q8WWV33, ENSP000003580594I2D: score=1 STRING: ENSP00000358059
About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007409axonogenesis NAS11201742
GO:0048011nerve growth factor receptor signaling pathway TAS--
GO:0050770regulation of axonogenesis TAS--
GO:0050771negative regulation of axonogenesis TAS--


RTN4R for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RTN4R for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for RTN4R available from Tocris Bioscience    About this table
CompoundAction CAS #
Nogo-66 (1-40)Competitive antagonist for Nogo-66 receptor; promotes neuron regeneration[475221-20-6]

1 DrugBank Compound for RTN4R    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Alpha-D-Mannose-- 3458-28-4target----

2 Novoseek chemical compound relationships for RTN4R gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
zinc 0 1 15629437 (1)
alanine 0 1 16061255 (1)

Search CenterWatch for drugs/clinical trials and news about RTN4R 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RTN4R gene: 
NM_023004.5  

Unigene Cluster for RTN4R:

Reticulon 4 receptor
Hs.30868  [show with all ESTs]
Unigene Representative Sequence: AK054602
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000416372 ENST00000043402(uc002zrv.3) ENST00000425986(uc002zru.3)
ENST00000469601 ENST00000474642 ENST00000463936

miRNA
Products:
     
OriGene 3'-UTR Clone: RTN4R
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RTN4R
8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate RTN4R (see all 18):
hsa-miR-30c hsa-miR-875-3p hsa-miR-3607-3p hsa-miR-10b hsa-miR-30d hsa-miR-30a hsa-miR-3658 hsa-miR-3662
SwitchGear 3'UTR luciferase reporter plasmidRTN4R 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RTN4R (see all 7)
OriGene shRNA RFP: RTN4R
OriGene siRNA: RTN4R
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RTN4R
Clone
Products:
     
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RTN4R (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RTN4R
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: RTN4R (NM_023004)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RTN4R
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTN4R 
Primer
Products:
    
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RTN4R
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RTN4R
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RTN4R
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTN4R

Additional cDNA sequence: 

AF283463.1 AK054602.1 AL834449.1 BC011787.1 CR456360.1 

8 DOTS entries:

DT.210488  DT.100816948  DT.100753306  DT.100816952  DT.100837695  DT.100009883  DT.100816950  DT.120663684 

24/99 AceView cDNA sequences (see all 99):

AA436362 BU633714 CR595137 AW166810 BX282103 NM_023004 H62405 BC011787 
BI760526 AI745288 BQ940700 AI820935 AL834449 BI820262 BM975407 BE350305 
CR601215 BM723620 CR590252 AK054602 CR604107 CR620900 BX326672 BX453227 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RTN4R expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTACAGGGT

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See RTN4R Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RTN4R

SOURCE GeneReport for Unigene cluster: Hs.30868

UniProtKB/Swiss-Prot: RTN4R_HUMAN, Q9BZR6
Tissue specificity: Widespread in the brain but highest levels in the gray matter. Low levels in heart and kidney not
expressed in oligodendrocytes (white matter)

    SABiosciences Custom PCR Arrays for RTN4R
Primer
Products:
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RTN4R
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RTN4R
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RTN4R
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTN4R
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4R

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for RTN4R gene from 3/12 species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves RTN4R1 reticulon 4 receptor 59.44(n)
56.88(a)
  417001  XM_415292.3  XP_415292.3 
lizard
(Anolis carolinensis)
Reptilia RTN4R6
--
50(a)
1 ↔ 1
GL343417.1(594958-596568)
zebrafish
(Danio rerio)
Actinopterygii LOC1003323741 reticulon-4 receptor-like 54.11(n)
48.37(a)
  100332374  XM_002661960.1  XP_002662006.1 


ENSEMBL Gene Tree for RTN4R (if available)
TreeFam Gene Tree for RTN4R (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for RTN4R gene
NYX2  LRRC532  LRRC702  RTN4RL12  RTN4RL22  
3 SIMAP similar genes for RTN4R using alignment to 3 protein entries:     RTN4R_HUMAN (see all proteins):
RTN4RL2    RTN4RL1    SLIT2

RTN4R for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/542 NCBI SNPs in RTN4R are shown (see all 542    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs743155091,2
Cother20230069(-) CGAGCG/ACGCCT 2 /H /R mis11Minor allele frequency- A:0.00NA 4536
rs743155081,2
C,other20230301(-) AGCTCC/TGGTCT 2 R W mis11Minor allele frequency- T:0.00NA 4388
rs7014291,2
C,F,--20228465(+) GTGGGG/TTCTAG 1 -- ds50016Minor allele frequency- T:0.18NA EA 380
rs586605061,2
C,--20228486(+) AGCAGC/TGGTGT 1 -- ds50011Minor allele frequency- T:0.50WA 2
rs8877641,2
F,--20228487(+) GCAGCG/AGTGTG 1 -- ds50011Minor allele frequency- A:0.05WA 118
rs7014281,2
C,F,A,H,--20228542(+) CGCCCG/AACTCT 1 -- ds500131Minor allele frequency- A:0.47NS EA NA WA CSA 3022
rs1155164141,2
F,--20228557(+) CAGGGC/ACTTCC 1 -- ds50011Minor allele frequency- A:0.07WA 118
rs1149952921,2
C,F,--20228594(+) ACAGGG/ATCCCT 1 -- ds50011Minor allele frequency- A:0.08WA 118
rs1829268671,2
--20228668(+) ACTGTA/CCCCAC 1 -- ds50010--------
rs1422802691,2
--20228698(+) CCCATC/GGACCT 1 -- ds50010--------

HapMap Linkage Disequilibrium report for RTN4R (20228938 - 20270769 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for RTN4R
     5 CNVs: 30153 4117 30157 31071 30154
Human Gene Mutation Database (HGMD): RTN4R

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RTN4R
DNA2.0 Custom Variant and Variant Library Synthesis for RTN4R

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RTN4R for disorders           About GeneDecksing

OMIM gene information: 605566   
OMIM disorders: 181500  
13 diseases for RTN4R:    About MalaCards
spinal cord injury    amyotrophic lateral sclerosis    lateral sclerosis    multiple sclerosis
neurodegenerative disease    dyslexia    squamous cell carcinoma    alzheimer's disease
schizophrenia    conjunctivitis    retinitis    carcinoma
neuronitis

5 Novoseek disease relationships for RTN4R gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
multiple sclerosis 24.4 1 18394723 (1)
scar 21.3 2 16646157 (1), 19597522 (1)
schizophrenia 0 8 19052207 (3), 15532024 (2), 16897606 (2)
neurodegenerative diseases 0 1 16179543 (1)
alzheimers disease 0 1 18394723 (1)

Genetic Association Database (GAD): RTN4R
Human Genome Epidemiology (HuGE) Navigator: RTN4R (7 documents)

Export disorders for RTN4R gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for RTN4R gene, integrated from 9 sources (see all 114):
(articles sorted by number of sources associating them with RTN4R)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. (PubMed id 11201742)1, 2, 3, 9 Fournier A.E.... Strittmatter S.M. (2001)
  2. Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. (PubMed id 12839991)1, 2, 9 Barton W.A.... Nikolov D.B. (2003)
  3. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. (PubMed id 12089450)1, 2, 9 Liu B.P.... Strittmatter S.M. (2002)
  4. Mutations of the Nogo-66 receptor (RTN4R) gene in schizophrenia. (PubMed id 15532024)1, 4, 9 Sinibaldi L....Dallapiccola B. (2004)
  5. Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition. (PubMed id 12718853)1, 2, 9 He X.L.... Garcia K.C. (2003)
  6. Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration. (PubMed id 11891768)1, 2, 9 Ng C.E.L. and Tang B.L. (2002)
  7. Dyslexia-associated kiaa0319-like protein interacts with axon guidance receptor nogo receptor 1. (PubMed id 20697954)1, 2 Poon M.W.... Waye M.M. (2011)
  8. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
  9. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
  10. LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. (PubMed id 14966521)1, 2 Mi S....Pepinsky R.B. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 65078 HGNC: 18601 AceView: RTN4R Ensembl:ENSG00000040608 euGenes: HUgn65078
ECgene: RTN4R H-InvDB: RTN4R

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for RTN4R Pharmacogenomics, SNPs, Pathways
Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt069.shtml

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for RTN4R gene:
Search GeneIP for patents involving RTN4R

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Antibodies for RTN4R (Nogo Receptor/NgR)   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for RTN4R (Nogo Receptor/NgR)  
 OriGene Antibodies for RTN4R   OriGene shRNA RFP for RTN4R  
 OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RTN4R   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RTN4R  
 OriGene Protein Over-expression Lysate for RTN4R   Browse OriGene Fluorogenic Cell Assay Kits  
 OriGene siRNA for RTN4R   OriGene 3'-UTR Clone for RTN4R  
 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RTN4R   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RTN4R  
 Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
 Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
 Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for RTN4R   OriGene Custom Protein Services for RTN4R  
 OriGene Custom Immunoassay Development  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RTN4R
 QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RTN4R
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RTN4R
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RTN4R
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTN4R
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RTN4R
 GenScript Custom Purified and Recombinant Proteins Services for RTN4R GenScript cDNA clones with any tag delivered in your preferred vector for RTN4R
 GenScript Custom Assay Services for RTN4R GenScript Custom Superior Antibodies Services for RTN4R
 GenScript Custom overexpressing Cell Line Services for RTN4R CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in RTN4R promoter
 Search Chromatin IP Primers for RTN4R
 RT2 qPCR Primer Assay in human, mouse, rat RTN4R
 GNC Network for RTN4R
 SABiosciences PCR Arrays including human, mouse, rat RTN4R
 Tocris compounds for RTN4R
 Proteins and Antibodies for RTN4R
 cDNA Clones for RTN4R
 Antibodies/Proteins Production Services
 Rabbit Monoclonal Antibody Platform
 Bulk Purchasing
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 RTN4R antibodies
 RTN4R proteins
 RTN4R lysates
 Search for Antibodies for RTN4R at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for RTN4R
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 RTN4R Proteins, Antibodies, CLIAs, and ELISAs
 Search LifeMap BioReagents cell lines for RTN4R
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4R
 SwitchGear 3'UTR luciferase reporter plasmids for RTN4R
 SwitchGear Promoter luciferase reporter plasmids for RTN4R
 ThermoFisher Antibodies for RTN4R
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTN4R
       
GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category
VWF
(GIFTS: 73)
von Willebrand factor
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      RTN4R gene at Home site.
hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4