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RTN4R Gene

protein-coding   GIFtS: 60
GCID: GC22M020234

Reticulon 4 Receptor

  See RTN4R-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Reticulon 4 Receptor1 2     NGR2
NOGOR2 3 5     UNQ330/PRO5262
Nogo Receptor2 3     Reticulon-4 Receptor2
Nogo-66 Receptor2 3     NgR3

External Ids:    HGNC: 186011   Entrez Gene: 650782   Ensembl: ENSG000000406087   OMIM: 6055665   UniProtKB: Q9BZR63   

Export aliases for RTN4R gene to outside databases

Previous GC identifers: GC22M017169 GC22M018603 GC22M003848


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RTN4R Gene:
This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated
glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal
regeneration and plasticity in the adult central nervous system. (provided by RefSeq, Jul 2008)

GeneCards Summary for RTN4R Gene:
RTN4R (reticulon 4 receptor) is a protein-coding gene. Diseases associated with RTN4R include schizophrenia. GO annotations related to this gene include receptor activity. An important paralog of this gene is NYX.

UniProtKB/Swiss-Prot: RTN4R_HUMAN, Q9BZR6
Function: Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating
axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1
in regulating neuronal precursor cell motility during cortical development (By similarity)

Gene Wiki entry for RTN4R (Reticulon 4 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the RTN4R gene promoter:
         STAT5B   STAT1   STAT4   STAT6   STAT1beta   STAT5A   STAT1alpha   AREB6   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRTN4R promoter sequence
   Search Chromatin IP Primers for RTN4R

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RTN4R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11

RTN4R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTN4R gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M020234:  view genomic region     (about GC identifiers)

Start:
20,228,938 bp from pter      End:
20,270,769 bp from pter
Size:
41,832 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RTN4R_HUMAN, Q9BZR6 (See protein sequence)
Recommended Name: Reticulon-4 receptor precursor  
Size: 473 amino acids; 50708 Da
Subunit: Homomultimer. Interacts with LINGO1. Interacts with KIAA0319L
2 PDB 3D structures from and Proteopedia for RTN4R:
1OZN (3D)        1P8T (3D)    
Secondary accessions: D3DX28

Explore the universe of human proteins at neXtProt for RTN4R: NX_Q9BZR6

Explore proteomics data for RTN4R at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn82, Asn179, Asn372

  • See RTN4R Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_075380.1  
    ENSEMBL proteins: 
     ENSP00000396872   ENSP00000043402   ENSP00000403535  
    Reactome Protein details: Q9BZR6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000483 Cys-rich_flank_reg_C
     IPR000372 LRR-contain_N
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp

    Graphical View of Domain Structure for InterPro Entry Q9BZR6

    ProtoNet protein and cluster: Q9BZR6

    3 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: RTN4R_HUMAN, Q9BZR6
    Similarity: Belongs to the Nogo receptor family
    Similarity: Contains 8 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    Find genes that share domains with RTN4R           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RTN4R_HUMAN, Q9BZR6
    Function: Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating
    axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1
    in regulating neuronal precursor cell motility during cortical development (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity NAS11201742
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with RTN4R           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RTN4R:
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Rtn4r):
     behavior/neurological  cellular  homeostasis/metabolism  nervous system  no phenotypic analysis 

    Find genes that share phenotypes with RTN4R           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RTN4R: Rtn4rtm1Gogo Rtn4rtm1Stmr Rtn4rtm1.1Pado Rtn4rtm1Matl

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    SwitchGear 3'UTR luciferase reporter plasmidRTN4R 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RTN4R_HUMAN, Q9BZR6: Cell membrane; Lipid-anchor, GPI-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum4
    cytoskeleton3
    mitochondrion2
    cytosol1
    extracellular1
    golgi apparatus1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IDA--
    GO:0016020membrane ----
    GO:0031225anchored component of membrane IEA--

    Find genes that share ontologies with RTN4R           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RTN4R About    
    See pathways by source

    SuperPathContained pathways About
    1Cell adhesion Integrin mediated cell adhesion and migration
    Development MAG dependent inhibition of neurite outgrowth0.46
    2Spinal Cord Injury
    Spinal Cord Injury
    3p75(NTR)-mediated signaling
    p75(NTR)-mediated signaling
    4NgR-p75(NTR)-Mediated Signaling
    NgR-p75(NTR)-Mediated Signaling
    5Guidance Cues and Growth Cone Motility
    Guidance Cues and Growth Cone Motility


    Find genes that share SuperPaths with RTN4R           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RTN4R
        Guidance Cues and Growth Cone Motility
    NgR-p75(NTR)-Mediated Signaling

    1 GeneGo (Thomson Reuters) Pathway for RTN4R
        Development MAG-dependent inhibition of neurite outgrowth

    2 BioSystems Pathways for RTN4R
        Spinal Cord Injury
    p75(NTR)-mediated signaling


    1 Reactome Pathway for RTN4R
        Axonal growth inhibition (RHOA activation)


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RTN4R
    Interactions:

        GeneGlobe Interaction Network for RTN4R

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for RTN4R (Q9BZR61, 3 ENSP000000434024) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NGFRP081383, ENSP000001722294I2D: score=4 STRING: ENSP00000172229
    RTN4Q9NQC33, ENSP000003378384I2D: score=3 STRING: ENSP00000337838
    LINGO1Q96FE53, ENSP000003474514I2D: score=2 STRING: ENSP00000347451
    OMGP235153, ENSP000002472714I2D: score=1 STRING: ENSP00000247271
    RTN4IP1Q8WWV33, ENSP000003580594I2D: score=1 STRING: ENSP00000358059
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007409axonogenesis NAS11201742
    GO:0048011neurotrophin TRK receptor signaling pathway TAS--
    GO:0050770regulation of axonogenesis TAS--
    GO:0050771negative regulation of axonogenesis TAS--

    Find genes that share ontologies with RTN4R           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for RTN4R available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PLP (139-151)Encephalitogenic myelin proteolipid fragment[122018-58-0]
    ONO 2506Inhibits S100B synthesis; neuroprotective[185517-21-9]
    C3bot (154-182)Neurotrophic fragment of clostridial C3 protein[1246280-79-4]
    MOG (35-55)Encephalitogenic myelin oligodendrocyte glycoprotein fragment[149635-73-4]
    Nogo-66 (1-40)Competitive antagonist for Nogo-66 receptor; promotes neuron regeneration[475221-20-6]

    1 DrugBank Compound for RTN4R    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-D-Mannose-- 3458-28-4target----

    2 Novoseek inferred chemical compound relationships for RTN4R gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 0 1 15629437 (1)
    alanine 0 1 16061255 (1)



    Find genes that share compounds with RTN4R           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RTN4R gene: 
    NM_023004.5  

    Unigene Cluster for RTN4R:

    Reticulon 4 receptor
    Hs.30868  [show with all ESTs]
    Unigene Representative Sequence: AK054602
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000416372 ENST00000043402(uc002zrv.3) ENST00000425986(uc002zru.3)
    ENST00000469601 ENST00000474642 ENST00000463936
    miRNA
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    hsa-miR-30c hsa-miR-875-3p hsa-miR-3607-3p hsa-miR-10b hsa-miR-30d hsa-miR-30a hsa-miR-3658 hsa-miR-3662
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    Additional mRNA sequence: 

    AF283463.1 AK054602.1 AL834449.1 BC011787.1 CR456360.1 

    8 DOTS entries:

    DT.210488  DT.100816948  DT.100753306  DT.100816952  DT.100837695  DT.100009883  DT.100816950  DT.120663684 

    Selected AceView cDNA sequences (see all 99):

    CR604107 CR590252 BX453227 BE350305 CR595137 AF283463 AW166810 CR601215 
    AK054602 BM975407 BI760526 BI820262 BU633714 AA436362 BQ940700 CR620900 
    H62405 AI745288 BC011787 AI820935 BX282103 BX326672 BM723620 NM_023004 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RTN4R expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTACAGGGT
    RTN4R Expression
    About this image

    RTN4R Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RTN4R Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.30868

    UniProtKB/Swiss-Prot: RTN4R_HUMAN, Q9BZR6
    Tissue specificity: Widespread in the brain but highest levels in the gray matter. Low levels in heart and kidney
    not expressed in oligodendrocytes (white matter)

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4R

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RTN4R gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rtn4r1 , 5 reticulon 4 receptor1, 5 82.66(n)1
    89.43(a)1
      16 (11.23 cM)5
    650791  NM_022982.21  NP_075358.11 
     181276425 
    chicken
    (Gallus gallus)
    Aves RTN4R1 reticulon 4 receptor 59.74(n)
    58.88(a)
      417001  XM_415292.4  XP_415292.4 
    lizard
    (Anolis carolinensis)
    Reptilia RTN4R6
    reticulon 4 receptor
    45(a)
    1 ↔ 1
    GL343417.1(594131-652448)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004859661 reticulon-4 receptor-like 49.65(n)
    49.88(a)
      100485966  XM_002932103.2  XP_002932149.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003323741 reticulon-4 receptor-like 54.34(n)
    49.16(a)
      100332374  XM_002661960.2  XP_002662006.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG15046
    --
    20(a)
    1 → many
    X(20181336-20186734)
    worm
    (Caenorhabditis elegans)
    Secernentea lron-126
    Protein LRON-12 (lron-12) mRNA, complete cds
    16(a)
    1 → many
    III(12114564-12118470) WBGene00013542


    ENSEMBL Gene Tree for RTN4R (if available)
    TreeFam Gene Tree for RTN4R (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RTN4R gene
    NYX2  LRRC532  LRRC702  RTN4RL12  RTN4RL22  
    3 SIMAP similar genes for RTN4R using alignment to 3 protein entries:     RTN4R_HUMAN (see all proteins):
    RTN4RL2    RTN4RL1    SLIT2

    Find genes that share paralogs with RTN4R           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RTN4R (see all 648)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs743155091,2
    Cother120230069(-) CGAGCG/ACGCCT 2 /H /R mis11Minor allele frequency- A:0.00NA 4536
    rs743155081,2
    Cother120230301(-) AGCTCC/TGGTCT 2 R W mis11Minor allele frequency- T:0.00NA 4388
    rs7014291,2
    C,F--20228465(+) GTGGGG/TTCTAG 1 -- ds50016Minor allele frequency- T:0.18NA EA 380
    rs586605061,2
    C--20228486(+) AGCAGC/TGGTGT 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs8877641,2
    F--20228487(+) GCAGCG/AGTGTG 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs59939381,2
    C--20228496(+) TGAGGA/GTGCAT 1 -- ds50010--------
    rs7014281,2
    C,F,A,H--20228542(+) CGCCCG/AACTCT 1 -- ds500131Minor allele frequency- A:0.47NS EA NA WA CSA 3022
    rs1155164141,2
    F--20228557(+) CAGGGC/ACTTCC 1 -- ds50011Minor allele frequency- A:0.07WA 118
    rs1149952921,2
    C,F--20228594(+) ACAGGG/ATCCCT 1 -- ds50011Minor allele frequency- A:0.08WA 118
    rs1829268671,2
    C--20228668(+) ACTGTA/CCCCAC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for RTN4R (20228938 - 20270769 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RTN4R (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1003446CNV Deletion20482838
    nsv435744CNV Deletion17901297
    dgv4860n71CNV Loss21882294
    nsv914375CNV Loss21882294
    nsv471183CNV Loss18288195
    dgv4864n71CNV Loss21882294
    dgv4862n71CNV Loss21882294
    nsv834134CNV Loss17160897
    dgv4858n71CNV Loss21882294
    dgv4863n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): RTN4R
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RTN4R
    DNA2.0 Custom Variant and Variant Library Synthesis for RTN4R

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 605566   
    OMIM disorders: 181500  
    1 disease for RTN4R:    
    About MalaCards
    schizophrenia


    Find genes that share disorders with RTN4R           About GenesLikeMe

    5 Novoseek inferred disease relationships for RTN4R gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    multiple sclerosis 24.4 1 18394723 (1)
    scar 21.3 2 16646157 (1), 19597522 (1)
    schizophrenia 0 8 19052207 (3), 15532024 (2), 16897606 (2)
    neurodegenerative diseases 0 1 16179543 (1)
    alzheimers disease 0 1 18394723 (1)

    Genetic Association Database (GAD): RTN4R
    Human Genome Epidemiology (HuGE) Navigator: RTN4R (7 documents)

    Export disorders for RTN4R gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for RTN4R gene, integrated from 10 sources (see all 116):
    (articles sorted by number of sources associating them with RTN4R)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. (PubMed id 11201742)1, 2, 3, 9 Fournier A.E.... Strittmatter S.M. (Nature 2001)
    2. Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. (PubMed id 12839991)1, 2, 9 Barton W.A.... Nikolov D.B. (EMBO J. 2003)
    3. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. (PubMed id 12089450)1, 2, 9 Liu B.P.... Strittmatter S.M. (Science 2002)
    4. Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth. (PubMed id 19052207)1, 4, 9 Budel S....Strittmatter S.M. (J. Neurosci. 2008)
    5. Mutations of the Nogo-66 receptor (RTN4R) gene in schizophrenia. (PubMed id 15532024)1, 4, 9 Sinibaldi L....Dallapiccola B. (Hum. Mutat. 2004)
    6. No association between the genetic polymorphisms in the RTN4R gene and schizophrenia in the Chinese population. (PubMed id 16897606)1, 4, 9 Meng J....He L. (J Neural Transm 2007)
    7. Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition. (PubMed id 12718853)1, 2, 9 He X.L.... Garcia K.C. (Neuron 2003)
    8. Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration. (PubMed id 11891768)1, 2, 9 Ng C.E.L. and Tang B.L. (J. Neurosci. Res. 2002)
    9. Dyslexia-associated kiaa0319-like protein interacts with axon guidance receptor nogo receptor 1. (PubMed id 20697954)1, 2 Poon M.W.... Waye M.M. (Cell. Mol. Neurobiol. 2011)
    10. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (J Psychiatr Res 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 65078 HGNC: 18601 AceView: RTN4R Ensembl:ENSG00000040608 euGenes: HUgn65078
    ECgene: RTN4R H-InvDB: RTN4R

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RTN4R Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/069

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RTN4R gene:
    Search GeneIP for patents involving RTN4R

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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