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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RTN4R Gene

protein-coding   GIFtS: 60
GCID: GC22M020234

Reticulon 4 Receptor

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Reticulon 4 Receptor1 2     NGR2
NOGOR2 3 5     UNQ330/PRO5262
Nogo Receptor2 3     Reticulon-4 Receptor2
Nogo-66 Receptor2 3     NgR3

External Ids:    HGNC: 186011   Entrez Gene: 650782   Ensembl: ENSG000000406087   OMIM: 6055665   UniProtKB: Q9BZR63   

Export aliases for RTN4R gene to outside databases

Previous GC identifers: GC22M017169 GC22M018603 GC22M003848


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RTN4R Gene:
This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated
glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal
regeneration and plasticity in the adult central nervous system. (provided by RefSeq, Jul 2008)

GeneCards Summary for RTN4R Gene: 
RTN4R (reticulon 4 receptor) is a protein-coding gene. Diseases associated with RTN4R include dyslexia, and spinal cord injury, and among its related super-pathways are p75NTR regulates axonogenesis and Development MAG-dependent inhibition of neurite outgrowth. GO annotations related to this gene include protein binding and receptor activity. An important paralog of this gene is GP5.

UniProtKB/Swiss-Prot: RTN4R_HUMAN, Q9BZR6
Function: Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating
axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1
in regulating neuronal precursor cell motility during cortical development (By similarity)

Gene Wiki entry for RTN4R (Reticulon 4 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011519.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RTN4R gene promoter:
         STAT5B   STAT1   STAT4   STAT6   STAT1beta   STAT5A   STAT1alpha   AREB6   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRTN4R promoter sequence
   Search SABiosciences Chromatin IP Primers for RTN4R

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RTN4R


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11

RTN4R Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTN4R gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M020234:  view genomic region     (about GC identifiers)

Start:
20,228,938 bp from pter      End:
20,270,769 bp from pter
Size:
41,832 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RTN4R_HUMAN, Q9BZR6 (See protein sequence)
Recommended Name: Reticulon-4 receptor precursor  
Size: 473 amino acids; 50708 Da
Subunit: Homomultimer. Interacts with LINGO1. Interacts with KIAA0319L
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
2 PDB 3D structures from and Proteopedia for RTN4R:
1OZN (3D)        1P8T (3D)    
Secondary accessions: D3DX28

Explore the universe of human proteins at neXtProt for RTN4R: NX_Q9BZR6

Explore proteomics data for RTN4R at MOPED 

RTN4R Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

RTN4R Protein Expression

REFSEQ proteins: NP_075380.1  
ENSEMBL proteins: 
 ENSP00000396872   ENSP00000043402   ENSP00000403535  
Reactome Protein details: Q9BZR6
Human Recombinant Protein Products for RTN4R: 
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Sino Biological Cell Lysate for RTN4R 
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Cloud-Clone Corp. Proteins for RTN4R 

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005783endoplasmic reticulum IDA--
GO:0005886plasma membrane TAS--
GO:0009986cell surface IDA--
GO:0016020membrane NAS--
GO:0031225anchored to membrane IEA--

RTN4R for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for RTN4R


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro protein domains:
 IPR000483 Cys-rich_flank_reg_C
 IPR000372 LRR-contain_N
 IPR001611 Leu-rich_rpt
 IPR003591 Leu-rich_rpt_typical-subtyp

Graphical View of Domain Structure for InterPro Entry Q9BZR6

ProtoNet protein and cluster: Q9BZR6

3 Blocks protein domains:
IPB000372 Cysteine-rich flanking region
IPB000483 Cysteine-rich flanking region
IPB001611 Leucine-rich repeat signature


UniProtKB/Swiss-Prot: RTN4R_HUMAN, Q9BZR6
Similarity: Belongs to the Nogo receptor family
Similarity: Contains 8 LRR (leucine-rich) repeats
Similarity: Contains 1 LRRCT domain
Similarity: Contains 1 LRRNT domain


RTN4R for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: RTN4R_HUMAN, Q9BZR6
Function: Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating
axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1
in regulating neuronal precursor cell motility during cortical development (By similarity)

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004872receptor activity NAS11201742
GO:0005515protein binding IPI--
     
RTN4R for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for RTN4R:
 Increased gamma-H2AX phosphory 

     5 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Rtn4r):
 behavior/neurological  cellular  homeostasis/metabolism  nervous system  no phenotypic analysis 

RTN4R for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for RTN4R: Rtn4rtm1Stmr Rtn4rtm1Gogo Rtn4rtm1.1Pado Rtn4rtm1Matl

   inGenious Targeting Laboratory - Custom generated mouse model solutions for RTN4R 
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   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RTN4R 

miRNA
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hsa-miR-30c hsa-miR-875-3p hsa-miR-3607-3p hsa-miR-10b hsa-miR-30d hsa-miR-30a hsa-miR-3658 hsa-miR-3662
SwitchGear 3'UTR luciferase reporter plasmidRTN4R 3' UTR sequence
Inhib. RNA
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Gene Editing
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Clone
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Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4R


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for RTN4R About   (see all 9)                                                                                              See pathways by source

SuperPathContained pathways About
1Axonal growth inhibition (RHOA activation)
Axonal growth inhibition (RHOA activation)0.90
p75NTR regulates axonogenesis0.90
2Development MAG-dependent inhibition of neurite outgrowth
Development MAG-dependent inhibition of neurite outgrowth0.87
3Cell death signalling via NRAGE, NRIF and NADE
p75 NTR receptor-mediated signalling0.73
4Signaling by FGFR
Signalling by NGF0.71
5Signaling by GPCR
Signal Transduction0.55

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for RTN4R
    Development MAG-dependent inhibition of neurite outgrowth

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RTN4R
    Guidance Cues and Growth Cone Motility
NgR-p75(NTR)-Mediated Signaling

1 GeneGo (Thomson Reuters) Pathway for RTN4R
    Development MAG-dependent inhibition of neurite outgrowth

2 BioSystems Pathways for RTN4R
    Spinal Cord Injury
p75(NTR)-mediated signaling


5        Reactome Pathways for RTN4R
    Axonal growth inhibition (RHOA activation)
Signal Transduction
p75NTR regulates axonogenesis
Signalling by NGF
p75 NTR receptor-mediated signalling



RTN4R for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RTN4R

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/11 Interacting proteins for RTN4R (Q9BZR61, 3 ENSP000000434024) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
InteractantInteraction Details
GeneCardExternal ID(s)
NGFRP081383, ENSP000001722294I2D: score=4 STRING: ENSP00000172229
RTN4Q9NQC33, ENSP000003378384I2D: score=3 STRING: ENSP00000337838
LINGO1Q96FE53, ENSP000003474514I2D: score=2 STRING: ENSP00000347451
OMGP235153, ENSP000002472714I2D: score=1 STRING: ENSP00000247271
RTN4IP1Q8WWV33, ENSP000003580594I2D: score=1 STRING: ENSP00000358059
About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007409axonogenesis NAS11201742
GO:0048011neurotrophin TRK receptor signaling pathway TAS--
GO:0050770regulation of axonogenesis TAS--
GO:0050771negative regulation of axonogenesis TAS--

RTN4R for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RTN4R for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for RTN4R available from Tocris Bioscience    About this table
CompoundAction CAS #
PLP (139-151)Encephalitogenic myelin proteolipid fragment[122018-58-0]
ONO 2506Inhibits S100B synthesis; neuroprotective[185517-21-9]
C3bot (154-182)Neurotrophic fragment of clostridial C3 protein[1246280-79-4]
MOG (35-55)Encephalitogenic myelin oligodendrocyte glycoprotein fragment[149635-73-4]
Nogo-66 (1-40)Competitive antagonist for Nogo-66 receptor; promotes neuron regeneration[475221-20-6]

1 DrugBank Compound for RTN4R    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Alpha-D-Mannose-- 3458-28-4target----

2 Novoseek inferred chemical compound relationships for RTN4R gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
zinc 0 1 15629437 (1)
alanine 0 1 16061255 (1)

Search CenterWatch for drugs/clinical trials and news about RTN4R

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RTN4R gene: 
NM_023004.5  

Unigene Cluster for RTN4R:

Reticulon 4 receptor
Hs.30868  [show with all ESTs]
Unigene Representative Sequence: AK054602
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000416372 ENST00000043402(uc002zrv.3) ENST00000425986(uc002zru.3)
ENST00000469601 ENST00000474642 ENST00000463936

miRNA
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8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate RTN4R (see all 18):
hsa-miR-30c hsa-miR-875-3p hsa-miR-3607-3p hsa-miR-10b hsa-miR-30d hsa-miR-30a hsa-miR-3658 hsa-miR-3662
SwitchGear 3'UTR luciferase reporter plasmidRTN4R 3' UTR sequence
Inhib. RNA
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Additional mRNA sequence: 

AF283463.1 AK054602.1 AL834449.1 BC011787.1 CR456360.1 

8 DOTS entries:

DT.210488  DT.100816948  DT.100753306  DT.100816952  DT.100837695  DT.100009883  DT.100816950  DT.120663684 

24/99 AceView cDNA sequences (see all 99):

BI760526 CR620900 AF283463 CR604107 AK054602 AI745288 AW166810 BX453227 
CR601215 BI820262 BM975407 CR590252 BM723620 BE350305 H62405 NM_023004 
AI820935 BC011787 BX326672 AL834449 BU633714 BQ940700 AA436362 BX282103 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RTN4R expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTACAGGGT
RTN4R Expression
About this image


See RTN4R Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RTN4R

SOURCE GeneReport for Unigene cluster: Hs.30868

UniProtKB/Swiss-Prot: RTN4R_HUMAN, Q9BZR6
Tissue specificity: Widespread in the brain but highest levels in the gray matter. Low levels in heart and kidney
not expressed in oligodendrocytes (white matter)

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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTN4R
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4R

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for RTN4R gene from 4/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rtn4r1 , 5 reticulon 4 receptor1, 5 82.66(n)1
89.43(a)1
  16 (11.23 cM)5
650791  NM_022982.21  NP_075358.11 
 181276425 
chicken
(Gallus gallus)
Aves RTN4R1 reticulon 4 receptor 59.44(n)
56.88(a)
  417001  XM_415292.3  XP_415292.3 
lizard
(Anolis carolinensis)
Reptilia RTN4R6
reticulon 4 receptor
44(a)
1 ↔ 1
GL343417.1(594131-652448)
zebrafish
(Danio rerio)
Actinopterygii LOC1003323741 reticulon-4 receptor-like 54.11(n)
48.37(a)
  100332374  XM_002661960.1  XP_002662006.1 


ENSEMBL Gene Tree for RTN4R (if available)
TreeFam Gene Tree for RTN4R (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for RTN4R gene
GP52  CPN22  LRRC152  LRRTM32  IGFALS2  LRIG12  LRRTM22  LRRTM12  
LRG12  NYX2  LRIG32  LRRTM42  CHAD2  LRIG22  CHADL2  RTN4RL12  
LRRC702  RTN4RL22  
3 SIMAP similar genes for RTN4R using alignment to 3 protein entries:     RTN4R_HUMAN (see all proteins):
RTN4RL2    RTN4RL1    SLIT2

RTN4R for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/648 SNPs in RTN4R are shown (see all 648)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs743155091,2
Cother120230069(-) CGAGCG/ACGCCT 2 /H /R mis11Minor allele frequency- A:0.00NA 4536
rs743155081,2
Cother120230301(-) AGCTCC/TGGTCT 2 R W mis11Minor allele frequency- T:0.00NA 4388
rs7014291,2
C,F--20228465(+) GTGGGG/TTCTAG 1 -- ds50016Minor allele frequency- T:0.18NA EA 380
rs586605061,2
C--20228486(+) AGCAGC/TGGTGT 1 -- ds50011Minor allele frequency- T:0.50WA 2
rs8877641,2
F--20228487(+) GCAGCG/AGTGTG 1 -- ds50011Minor allele frequency- A:0.05WA 118
rs59939381,2
C--20228496(+) TGAGGA/GTGCAT 1 -- ds50010--------
rs7014281,2
C,F,A,H--20228542(+) CGCCCG/AACTCT 1 -- ds500131Minor allele frequency- A:0.47NS EA NA WA CSA 3022
rs1155164141,2
F--20228557(+) CAGGGC/ACTTCC 1 -- ds50011Minor allele frequency- A:0.07WA 118
rs1149952921,2
C,F--20228594(+) ACAGGG/ATCCCT 1 -- ds50011Minor allele frequency- A:0.08WA 118
rs1829268671,2
C--20228668(+) ACTGTA/CCCCAC 1 -- ds50010--------

HapMap Linkage Disequilibrium report for RTN4R (20228938 - 20270769 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/16 variations for RTN4R (see all 16):    About this table     
Variant IDTypeSubtypePubMed ID
esv1003446CNV Deletion20482838
nsv435744CNV Deletion17901297
dgv4860n71CNV Loss21882294
nsv914375CNV Loss21882294
nsv471183CNV Loss18288195
dgv4864n71CNV Loss21882294
dgv4862n71CNV Loss21882294
nsv834134CNV Loss17160897
dgv4858n71CNV Loss21882294
dgv4863n71CNV Loss21882294


Human Gene Mutation Database (HGMD): RTN4R
SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 605566   
OMIM disorders: 181500  
14 diseases for RTN4R:    About MalaCards
dyslexia    spinal cord injury    schizophrenia    conjunctivitis
multiple sclerosis    amyotrophic lateral sclerosis    lateral sclerosis    alzheimer's disease
mental retardation    astrocytoma    retinitis    squamous cell carcinoma
neuronitis    gastric cancer


RTN4R for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

5 Novoseek inferred disease relationships for RTN4R gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
multiple sclerosis 24.4 1 18394723 (1)
scar 21.3 2 16646157 (1), 19597522 (1)
schizophrenia 0 8 19052207 (3), 15532024 (2), 16897606 (2)
neurodegenerative diseases 0 1 16179543 (1)
alzheimers disease 0 1 18394723 (1)

Genetic Association Database (GAD): RTN4R
Human Genome Epidemiology (HuGE) Navigator: RTN4R (7 documents)

Export disorders for RTN4R gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RTN4R gene, integrated from 9 sources (see all 116):
(articles sorted by number of sources associating them with RTN4R)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. (PubMed id 11201742)1, 2, 3, 9 Fournier A.E.... Strittmatter S.M. (2001)
  2. Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. (PubMed id 12839991)1, 2, 9 Barton W.A.... Nikolov D.B. (2003)
  3. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. (PubMed id 12089450)1, 2, 9 Liu B.P.... Strittmatter S.M. (2002)
  4. Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth. (PubMed id 19052207)1, 4, 9 Budel S....Strittmatter S.M. (2008)
  5. Mutations of the Nogo-66 receptor (RTN4R) gene in schizophrenia. (PubMed id 15532024)1, 4, 9 Sinibaldi L....Dallapiccola B. (2004)
  6. No association between the genetic polymorphisms in the RTN4R gene and schizophrenia in the Chinese population. (PubMed id 16897606)1, 4, 9 Meng J....He L. (2007)
  7. Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition. (PubMed id 12718853)1, 2, 9 He X.L.... Garcia K.C. (2003)
  8. Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration. (PubMed id 11891768)1, 2, 9 Ng C.E.L. and Tang B.L. (2002)
  9. Dyslexia-associated kiaa0319-like protein interacts with axon guidance receptor nogo receptor 1. (PubMed id 20697954)1, 2 Poon M.W.... Waye M.M. (2011)
  10. Comprehensive copy number variant (CNV) analysis of n euronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 65078 HGNC: 18601 AceView: RTN4R Ensembl:ENSG00000040608 euGenes: HUgn65078
ECgene: RTN4R H-InvDB: RTN4R

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for RTN4R Pharmacogenomics, SNPs, Pathways
Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt069.shtml

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for RTN4R gene:
Search GeneIP for patents involving RTN4R

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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