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Aliases for RTN4R Gene

Aliases for RTN4R Gene

  • Reticulon 4 Receptor 2 3 5
  • Nogo-66 Receptor 3 4
  • Nogo Receptor 3 4
  • NOGOR 3 4
  • NGR 3 4
  • UNQ330/PRO526 3

External Ids for RTN4R Gene

Previous GeneCards Identifiers for RTN4R Gene

  • GC22M017169
  • GC22M018603
  • GC22M003848

Summaries for RTN4R Gene

Entrez Gene Summary for RTN4R Gene

  • This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for RTN4R Gene

RTN4R (Reticulon 4 Receptor) is a Protein Coding gene. Diseases associated with RTN4R include schizophrenia and spinal cord injury. Among its related pathways are Guidance Cues and Growth Cone Motility and Spinal Cord Injury. GO annotations related to this gene include receptor activity. An important paralog of this gene is TPBGL.

UniProtKB/Swiss-Prot for RTN4R Gene

  • Receptor for RTN4, OMG and MAG. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development.

Tocris Summary for RTN4R Gene

Gene Wiki entry for RTN4R Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTN4R Gene

Genomics for RTN4R Gene

Regulatory Elements for RTN4R Gene

Genomic Location for RTN4R Gene

Chromosome:
22
Start:
20,241,415 bp from pter
End:
20,283,246 bp from pter
Size:
41,832 bases
Orientation:
Minus strand

Genomic View for RTN4R Gene

Genes around RTN4R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTN4R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTN4R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTN4R Gene

Proteins for RTN4R Gene

  • Protein details for RTN4R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZR6-RTN4R_HUMAN
    Recommended name:
    Reticulon-4 receptor
    Protein Accession:
    Q9BZR6
    Secondary Accessions:
    • D3DX28

    Protein attributes for RTN4R Gene

    Size:
    473 amino acids
    Molecular mass:
    50708 Da
    Quaternary structure:
    • Homomultimer. Interacts with LINGO1. Interacts with KIAA0319L. Interacts with NGFR (By similarity). Interacts with OLFM1; this inhibits interaction with LINGO1 and NGFR (By similarity).

    Three dimensional structures from OCA and Proteopedia for RTN4R Gene

neXtProt entry for RTN4R Gene

Proteomics data for RTN4R Gene at MOPED

Post-translational modifications for RTN4R Gene

  • Glycosylation at Asn 82, Asn 179, and Asn 372

Other Protein References for RTN4R Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for RTN4R (Nogo Receptor/NgR)

No data available for DME Specific Peptides for RTN4R Gene

Domains & Families for RTN4R Gene

Suggested Antigen Peptide Sequences for RTN4R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZR6

UniProtKB/Swiss-Prot:

RTN4R_HUMAN :
  • Contains 1 LRRCT domain.
  • Belongs to the Nogo receptor family.
  • Contains 8 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Family:
  • Belongs to the Nogo receptor family.
Similarity:
  • Contains 8 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with RTN4R: view

No data available for Gene Families for RTN4R Gene

Function for RTN4R Gene

Molecular function for RTN4R Gene

UniProtKB/Swiss-Prot Function:
Receptor for RTN4, OMG and MAG. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development.

Gene Ontology (GO) - Molecular Function for RTN4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
GO:0005515 protein binding IEA,IPI 20463223
genes like me logo Genes that share ontologies with RTN4R: view
genes like me logo Genes that share phenotypes with RTN4R: view

Animal Models for RTN4R Gene

MGI Knock Outs for RTN4R:

Animal Model Products

  • Taconic Biosciences Mouse Models for RTN4R

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RTN4R Gene

Localization for RTN4R Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTN4R Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RTN4R Gene COMPARTMENTS Subcellular localization image for RTN4R gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 4
cytoskeleton 3
mitochondrion 2
cytosol 1
golgi apparatus 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RTN4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005886 plasma membrane IEA,TAS --
GO:0031225 anchored component of membrane IEA --
GO:0043005 neuron projection IEA,ISS --
genes like me logo Genes that share ontologies with RTN4R: view

Pathways & Interactions for RTN4R Gene

genes like me logo Genes that share pathways with RTN4R: view

Pathways by source for RTN4R Gene

2 BioSystems pathways for RTN4R Gene
1 GeneGo (Thomson Reuters) pathway for RTN4R Gene

Gene Ontology (GO) - Biological Process for RTN4R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007409 axonogenesis IEA,NAS 11201742
GO:0023041 neuronal signal transduction IEA,ISS --
GO:0030517 negative regulation of axon extension IEA,ISS --
GO:0043547 positive regulation of GTPase activity IEA,ISS --
GO:0046426 negative regulation of JAK-STAT cascade IBA --
genes like me logo Genes that share ontologies with RTN4R: view

No data available for SIGNOR curated interactions for RTN4R Gene

Drugs & Compounds for RTN4R Gene

(2) Drugs for RTN4R Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for RTN4R Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
B2
115687-05-3
Etifoxine hydrochloride
56776-32-0
MOG (35-55)
149635-73-4
Nogo-66 (1-40)
475221-20-6
PLP (139-151)
122018-58-0
genes like me logo Genes that share compounds with RTN4R: view

Transcripts for RTN4R Gene

Unigene Clusters for RTN4R Gene

Reticulon 4 receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RTN4R Gene

No ASD Table

Relevant External Links for RTN4R Gene

GeneLoc Exon Structure for
RTN4R
ECgene alternative splicing isoforms for
RTN4R

Expression for RTN4R Gene

mRNA expression in normal human tissues for RTN4R Gene

mRNA differential expression in normal tissues according to GTEx for RTN4R Gene

This gene is overexpressed in Brain - Cerebellum (x7.3), Brain - Cerebellar Hemisphere (x6.8), Brain - Cortex (x6.8), Brain - Frontal Cortex (BA9) (x5.1), and Brain - Anterior cingulate cortex (BA24) (x4.3).

Protein differential expression in normal tissues from HIPED for RTN4R Gene

This gene is overexpressed in Cerebrospinal fluid (54.3) and Fetal Brain (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RTN4R Gene



SOURCE GeneReport for Unigene cluster for RTN4R Gene Hs.30868

mRNA Expression by UniProt/SwissProt for RTN4R Gene

Q9BZR6-RTN4R_HUMAN
Tissue specificity: Widespread in the brain but highest levels in the gray matter. Low levels in heart and kidney not expressed in oligodendrocytes (white matter).
genes like me logo Genes that share expression patterns with RTN4R: view

Protein tissue co-expression partners for RTN4R Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RTN4R Gene

Orthologs for RTN4R Gene

This gene was present in the common ancestor of animals.

Orthologs for RTN4R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RTN4R 35
  • 99.28 (n)
  • 99.78 (a)
RTN4R 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RTN4R 36
  • 86 (a)
OneToOne
RTN4R 35
  • 84.11 (n)
  • 86.86 (a)
dog
(Canis familiaris)
Mammalia RTN4R 35
  • 85.61 (n)
  • 87.7 (a)
mouse
(Mus musculus)
Mammalia Rtn4r 16
Rtn4r 35
  • 82.66 (n)
  • 89.43 (a)
Rtn4r 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RTN4R 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 26 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Rtn4r 35
  • 82.52 (n)
  • 88.16 (a)
chicken
(Gallus gallus)
Aves RTN4R 35
  • 59.74 (n)
  • 58.88 (a)
RTN4R 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RTN4R 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485966 35
  • 49.65 (n)
  • 49.88 (a)
zebrafish
(Danio rerio)
Actinopterygii rtn4r 36
  • 44 (a)
OneToMany
rtn4r 36
  • 43 (a)
OneToMany
LOC100332374 35
  • 54.34 (n)
  • 49.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1504 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lron-12 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToMany
Species with no ortholog for RTN4R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RTN4R Gene

ENSEMBL:
Gene Tree for RTN4R (if available)
TreeFam:
Gene Tree for RTN4R (if available)

Paralogs for RTN4R Gene

Paralogs for RTN4R Gene

(3) SIMAP similar genes for RTN4R Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RTN4R: view

Variants for RTN4R Gene

Sequence variations from dbSNP and Humsavar for RTN4R Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs701418 -- 20,265,803(+) GCATT(C/T)TGAGG intron-variant
rs701419 -- 20,264,580(+) tgaat(A/G)aacaa intron-variant
rs701420 -- 20,263,563(+) GCACC(C/T)GGGGG intron-variant
rs701422 -- 20,256,246(+) AGGGC(A/C)CAGAG intron-variant
rs701423 -- 20,255,782(+) GTGTG(C/T)GGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RTN4R Gene

Variant ID Type Subtype PubMed ID
nsv435744 CNV Deletion 17901297
nsv828938 CNV Gain 20364138
nsv828939 CNV Loss 20364138
nsv471183 CNV Loss 18288195
dgv1387e1 CNV Complex 17122850
dgv726n67 CNV Gain 20364138
dgv4855n71 CNV Loss 21882294
dgv4858n71 CNV Loss 21882294
dgv4860n71 CNV Loss 21882294
nsv834134 CNV Loss 17160897
dgv4862n71 CNV Loss 21882294
nsv914360 CNV Gain 21882294
dgv4863n71 CNV Loss 21882294
dgv4864n71 CNV Loss 21882294
nsv914375 CNV Loss 21882294
esv1003446 CNV Deletion 20482838

Variation tolerance for RTN4R Gene

Residual Variation Intolerance Score: 58.9% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RTN4R Gene

HapMap Linkage Disequilibrium report
RTN4R
Human Gene Mutation Database (HGMD)
RTN4R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTN4R Gene

Disorders for RTN4R Gene

MalaCards: The human disease database

(2) MalaCards diseases for RTN4R Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
spinal cord injury
  • spinal cord injuries
- elite association - COSMIC cancer census association via MalaCards
Search RTN4R in MalaCards View complete list of genes associated with diseases

Relevant External Links for RTN4R

Genetic Association Database (GAD)
RTN4R
Human Genome Epidemiology (HuGE) Navigator
RTN4R
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RTN4R
genes like me logo Genes that share disorders with RTN4R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RTN4R Gene

Publications for RTN4R Gene

  1. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. (PMID: 11201742) Fournier A.E. … Strittmatter S.M. (Nature 2001) 2 3 4 23 67
  2. Identification of BLyS (B lymphocyte stimulator), a non-myelin-associated protein, as a functional ligand for Nogo-66 receptor. (PMID: 19439611) Zhang L. … Zhang J. (J. Neurosci. 2009) 3 23
  3. Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth. (PMID: 19052207) Budel S. … Strittmatter S.M. (J. Neurosci. 2008) 3 23
  4. Increased expression of the Nogo receptor in the hippocampus and its relation to the neuropathology in Alzheimer's disease. (PMID: 17188332) Zhu H.Y. … Zhou J.N. (Hum. Pathol. 2007) 3 23
  5. No association between the genetic polymorphisms in the RTN4R gene and schizophrenia in the Chinese population. (PMID: 16897606) Meng J. … He L. (J Neural Transm 2007) 3 23

Products for RTN4R Gene

Sources for RTN4R Gene

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