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Aliases for RTN4IP1 Gene

Aliases for RTN4IP1 Gene

  • Reticulon 4 Interacting Protein 1 2 3 5
  • NOGO-Interacting Mitochondrial Protein 3 4
  • NIMP 3 4
  • OPA10 3

External Ids for RTN4IP1 Gene

Previous GeneCards Identifiers for RTN4IP1 Gene

  • GC06M106855
  • GC06M107041
  • GC06M107065
  • GC06M107126
  • GC06M104468

Summaries for RTN4IP1 Gene

Entrez Gene Summary for RTN4IP1 Gene

  • This gene encodes a mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor of regeneration following spinal cord injury. This interaction may be important for reticulon-induced inhibition of neurite growth. Mutations in this gene can cause optic atrophy 10, with or without ataxia, mental retardation, and seizures. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for RTN4IP1 Gene

RTN4IP1 (Reticulon 4 Interacting Protein 1) is a Protein Coding gene. Diseases associated with RTN4IP1 include Spinal Cord Injury. GO annotations related to this gene include oxidoreductase activity and transferase activity, transferring acyl groups other than amino-acyl groups. An important paralog of this gene is CRYZ.

UniProtKB/Swiss-Prot for RTN4IP1 Gene

  • Appears to be a potent inhibitor of regeneration following spinal cord injury.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTN4IP1 Gene

Genomics for RTN4IP1 Gene

Regulatory Elements for RTN4IP1 Gene

Enhancers for RTN4IP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RTN4IP1 on UCSC Golden Path with GeneCards custom track

Promoters for RTN4IP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RTN4IP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RTN4IP1 Gene

106,571,028 bp from pter
106,630,500 bp from pter
59,473 bases
Minus strand

Genomic View for RTN4IP1 Gene

Genes around RTN4IP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTN4IP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTN4IP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTN4IP1 Gene

Proteins for RTN4IP1 Gene

  • Protein details for RTN4IP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Reticulon-4-interacting protein 1, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q8N9B3
    • Q8WZ66
    • Q9BRA4

    Protein attributes for RTN4IP1 Gene

    396 amino acids
    Molecular mass:
    43590 Da
    Quaternary structure:
    • Interacts with RTN4, UQCRC1 and UQCRC2.

    Three dimensional structures from OCA and Proteopedia for RTN4IP1 Gene

    Alternative splice isoforms for RTN4IP1 Gene


neXtProt entry for RTN4IP1 Gene

Proteomics data for RTN4IP1 Gene at MOPED

Post-translational modifications for RTN4IP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTN4IP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RTN4IP1 Gene

Domains & Families for RTN4IP1 Gene

Suggested Antigen Peptide Sequences for RTN4IP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
genes like me logo Genes that share domains with RTN4IP1: view

No data available for Gene Families for RTN4IP1 Gene

Function for RTN4IP1 Gene

Molecular function for RTN4IP1 Gene

UniProtKB/Swiss-Prot Function:
Appears to be a potent inhibitor of regeneration following spinal cord injury.

Gene Ontology (GO) - Molecular Function for RTN4IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with RTN4IP1: view
genes like me logo Genes that share phenotypes with RTN4IP1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RTN4IP1

CRISPR Products

miRNA for RTN4IP1 Gene

miRTarBase miRNAs that target RTN4IP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RTN4IP1 Gene

Localization for RTN4IP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTN4IP1 Gene


Subcellular locations from

Jensen Localization Image for RTN4IP1 Gene COMPARTMENTS Subcellular localization image for RTN4IP1 gene
Compartment Confidence
mitochondrion 5
cytosol 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for RTN4IP1 Gene

Pathways & Interactions for RTN4IP1 Gene

SuperPathways for RTN4IP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RTN4IP1 Gene


No data available for Pathways by source and SIGNOR curated interactions for RTN4IP1 Gene

Drugs & Compounds for RTN4IP1 Gene

(2) Drugs for RTN4IP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
1-Butanol Experimental Pharma 0
1-Proponol Experimental Pharma 0

(4) Additional Compounds for RTN4IP1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
  • 1-Hydroxymethylpropane
  • 2-Methyl propanol
  • 2-Methyl-1-propanol
  • 2-Methyl-1-propanyl alcohol
  • 2-Methylpropan-1-ol
Isopropyl alcohol
  • 2-Propanol
  • 2-Propyl alcohol
  • Alcojel
  • Alkolave
  • Avantin
genes like me logo Genes that share compounds with RTN4IP1: view

Transcripts for RTN4IP1 Gene

Unigene Clusters for RTN4IP1 Gene

Reticulon 4 interacting protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RTN4IP1 Gene

No ASD Table

Relevant External Links for RTN4IP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RTN4IP1 Gene

mRNA expression in normal human tissues for RTN4IP1 Gene

Protein differential expression in normal tissues from HIPED for RTN4IP1 Gene

This gene is overexpressed in Stomach (8.3), Peripheral blood mononuclear cells (8.3), Lymph node (8.1), Tonsil (7.6), Heart (7.1), and Plasma (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RTN4IP1 Gene

SOURCE GeneReport for Unigene cluster for RTN4IP1 Gene Hs.155839

mRNA Expression by UniProt/SwissProt for RTN4IP1 Gene

Tissue specificity: Widely expressed in mitochondria-enriched tissues. Found in heart, muscle, kidney, liver, brain and placenta.
genes like me logo Genes that share expression patterns with RTN4IP1: view

Protein tissue co-expression partners for RTN4IP1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RTN4IP1 Gene

Orthologs for RTN4IP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RTN4IP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RTN4IP1 35
  • 90.4 (n)
  • 94.44 (a)
RTN4IP1 36
  • 94 (a)
(Canis familiaris)
Mammalia RTN4IP1 35
  • 90.66 (n)
  • 91.92 (a)
RTN4IP1 36
  • 85 (a)
(Mus musculus)
Mammalia Rtn4ip1 35
  • 88.13 (n)
  • 90.15 (a)
Rtn4ip1 16
Rtn4ip1 36
  • 90 (a)
(Pan troglodytes)
Mammalia RTN4IP1 35
  • 99.33 (n)
  • 99.24 (a)
RTN4IP1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rtn4ip1 35
  • 86.78 (n)
  • 90.91 (a)
(Monodelphis domestica)
Mammalia RTN4IP1 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia RTN4IP1 36
  • 80 (a)
(Gallus gallus)
Aves RTN4IP1 35
  • 74.48 (n)
  • 77.09 (a)
RTN4IP1 36
  • 75 (a)
(Anolis carolinensis)
Reptilia RTN4IP1 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rtn4ip1 35
  • 71.2 (n)
  • 71.39 (a)
Str.1966 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16364 35
(Danio rerio)
Actinopterygii rtn4ip1 35
  • 69.21 (n)
  • 70.62 (a)
zgc63964 35
rtn4ip1 36
  • 66 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4857 35
fruit fly
(Drosophila melanogaster)
Insecta CG17221 37
  • 36 (a)
CG17221 35
  • 48.96 (n)
  • 38.07 (a)
CG17221 36
  • 32 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009178 35
  • 47.44 (n)
  • 40 (a)
(Caenorhabditis elegans)
Secernentea rad-8 35
  • 48.07 (n)
  • 37.29 (a)
rad-8 36
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YIM1 36
  • 23 (a)
YIM1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G15090 35
  • 48.13 (n)
  • 35.96 (a)
(Oryza sativa)
Liliopsida Os01g0753100 35
  • 46.71 (n)
  • 36.47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for RTN4IP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RTN4IP1 Gene

Gene Tree for RTN4IP1 (if available)
Gene Tree for RTN4IP1 (if available)

Paralogs for RTN4IP1 Gene

Paralogs for RTN4IP1 Gene

(1) SIMAP similar genes for RTN4IP1 Gene using alignment to 2 proteins: Pseudogenes for RTN4IP1 Gene

genes like me logo Genes that share paralogs with RTN4IP1: view

Variants for RTN4IP1 Gene

Sequence variations from dbSNP and Humsavar for RTN4IP1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1026622 -- 106,604,450(+) gaagt(A/T)aagaa intron-variant
rs4946765 -- 106,574,170(+) CCCAG(C/T)GCAGT intron-variant
rs4946766 -- 106,578,042(+) TGTAT(A/C)AATAT intron-variant
rs4946767 -- 106,579,296(+) TCAGA(C/T)TGAAT intron-variant
rs4946768 -- 106,579,606(+) GAGAA(A/G)GCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RTN4IP1 Gene

Variant ID Type Subtype PubMed ID
esv2732544 CNV Deletion 23290073
esv2499647 CNV Insertion 19546169
esv2658148 CNV Deletion 23128226

Variation tolerance for RTN4IP1 Gene

Residual Variation Intolerance Score: 73.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RTN4IP1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTN4IP1 Gene

Disorders for RTN4IP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RTN4IP1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
spinal cord injury
  • spinal cord injuries
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RTN4IP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RTN4IP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RTN4IP1 Gene

Publications for RTN4IP1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Recessive Mutations in RTN4IP1 Cause Isolated and Syndromic Optic Neuropathies. (PMID: 26593267) Angebault C. … Lenaers G. (Am. J. Hum. Genet. 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for RTN4IP1 Gene

Sources for RTN4IP1 Gene