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Aliases for RTN4IP1 Gene

Aliases for RTN4IP1 Gene

  • Reticulon 4 Interacting Protein 1 2 3
  • NOGO-Interacting Mitochondrial Protein 3 4
  • NIMP 3 4

External Ids for RTN4IP1 Gene

Previous GeneCards Identifiers for RTN4IP1 Gene

  • GC06M106855
  • GC06M107041
  • GC06M107065
  • GC06M107126
  • GC06M104468

Summaries for RTN4IP1 Gene

Entrez Gene Summary for RTN4IP1 Gene

  • This gene encodes a novel mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor of regeneration following spinal cord injury. The interaction of reticulon 4 with mitochondrial proteins may provide insight into the mechanisms for reticulon-induced inhibition of neurite growth. [provided by RefSeq, Jul 2008]

GeneCards Summary for RTN4IP1 Gene

RTN4IP1 (Reticulon 4 Interacting Protein 1) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and transferase activity, transferring acyl groups other than amino-acyl groups.

UniProtKB/Swiss-Prot for RTN4IP1 Gene

  • Appears to be a potent inhibitor of regeneration following spinal cord injury

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTN4IP1 Gene

Genomics for RTN4IP1 Gene

Regulatory Elements for RTN4IP1 Gene

Genomic Location for RTN4IP1 Gene

Chromosome:
6
Start:
106,571,028 bp from pter
End:
106,630,500 bp from pter
Size:
59,473 bases
Orientation:
Minus strand

Genomic View for RTN4IP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for RTN4IP1 Gene

Proteins for RTN4IP1 Gene

  • Protein details for RTN4IP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWV3-RT4I1_HUMAN
    Recommended name:
    Reticulon-4-interacting protein 1, mitochondrial
    Protein Accession:
    Q8WWV3
    Secondary Accessions:
    • Q8N9B3
    • Q8WZ66
    • Q9BRA4

    Protein attributes for RTN4IP1 Gene

    Size:
    396 amino acids
    Molecular mass:
    43590 Da
    Quaternary structure:
    • Interacts with RTN4, UQCRC1 and UQCRC2.

    Three dimensional structures from OCA and Proteopedia for RTN4IP1 Gene

    Alternative splice isoforms for RTN4IP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RTN4IP1 Gene

Proteomics data for RTN4IP1 Gene at MOPED

Post-translational modifications for RTN4IP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTN4IP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RTN4IP1 Gene

Domains & Families for RTN4IP1 Gene

Suggested Antigen Peptide Sequences for RTN4IP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WWV3

UniProtKB/Swiss-Prot:

RT4I1_HUMAN :
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
genes like me logo Genes that share domains with RTN4IP1: view

No data available for Gene Families for RTN4IP1 Gene

Function for RTN4IP1 Gene

Molecular function for RTN4IP1 Gene

UniProtKB/Swiss-Prot Function:
Appears to be a potent inhibitor of regeneration following spinal cord injury

Gene Ontology (GO) - Molecular Function for RTN4IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with RTN4IP1: view
genes like me logo Genes that share phenotypes with RTN4IP1: view

Animal Model Products

CRISPR Products

miRNA for RTN4IP1 Gene

miRTarBase miRNAs that target RTN4IP1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RTN4IP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RTN4IP1 Gene

Localization for RTN4IP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTN4IP1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RTN4IP1 Gene COMPARTMENTS Subcellular localization image for RTN4IP1 gene
Compartment Confidence
mitochondrion 3

Gene Ontology (GO) - Cellular Components for RTN4IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with RTN4IP1: view

Pathways & Interactions for RTN4IP1 Gene

SuperPathways for RTN4IP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RTN4IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with RTN4IP1: view

No data available for Pathways by source and SIGNOR curated interactions for RTN4IP1 Gene

Drugs & Compounds for RTN4IP1 Gene

(2) Drugs for RTN4IP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
1-Butanol Experimental Pharma 0
1-Proponol Experimental Pharma 0

(4) Additional Compounds for RTN4IP1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Hexanol
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
111-27-3
1-Pentanol
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
71-41-0
Isobutanol
  • 1-Hydroxymethylpropane
  • 2-Methyl propanol
  • 2-Methyl-1-propanol
  • 2-Methyl-1-propanyl alcohol
  • 2-Methylpropan-1-ol
78-83-1
Isopropyl alcohol
  • 2-Propanol
  • 2-Propyl alcohol
  • Alcojel
  • Alkolave
  • Avantin
67-63-0
genes like me logo Genes that share compounds with RTN4IP1: view

Transcripts for RTN4IP1 Gene

Unigene Clusters for RTN4IP1 Gene

Reticulon 4 interacting protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RTN4IP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTN4IP1 Gene

No ASD Table

Relevant External Links for RTN4IP1 Gene

GeneLoc Exon Structure for
RTN4IP1
ECgene alternative splicing isoforms for
RTN4IP1

Expression for RTN4IP1 Gene

mRNA expression in normal human tissues for RTN4IP1 Gene

Protein differential expression in normal tissues from HIPED for RTN4IP1 Gene

This gene is overexpressed in Stomach (8.3), Peripheral blood mononuclear cells (8.3), Lymph node (8.1), Tonsil (7.6), Heart (7.1), and Plasma (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RTN4IP1 Gene



SOURCE GeneReport for Unigene cluster for RTN4IP1 Gene Hs.155839

mRNA Expression by UniProt/SwissProt for RTN4IP1 Gene

Q8WWV3-RT4I1_HUMAN
Tissue specificity: Widely expressed in mitochondria-enriched tissues. Found in heart, muscle, kidney, liver, brain and placenta.
genes like me logo Genes that share expression patterns with RTN4IP1: view

Protein tissue co-expression partners for RTN4IP1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RTN4IP1 Gene

Orthologs for RTN4IP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RTN4IP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RTN4IP1 35
  • 90.4 (n)
  • 94.44 (a)
RTN4IP1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RTN4IP1 35
  • 90.66 (n)
  • 91.92 (a)
RTN4IP1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rtn4ip1 35
  • 88.13 (n)
  • 90.15 (a)
Rtn4ip1 16
Rtn4ip1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RTN4IP1 35
  • 99.33 (n)
  • 99.24 (a)
RTN4IP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rtn4ip1 35
  • 86.78 (n)
  • 90.91 (a)
oppossum
(Monodelphis domestica)
Mammalia RTN4IP1 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RTN4IP1 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves RTN4IP1 35
  • 74.48 (n)
  • 77.09 (a)
RTN4IP1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RTN4IP1 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rtn4ip1 35
  • 71.2 (n)
  • 71.39 (a)
Str.1966 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16364 35
zebrafish
(Danio rerio)
Actinopterygii rtn4ip1 35
  • 69.21 (n)
  • 70.62 (a)
zgc63964 35
rtn4ip1 36
  • 66 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4857 35
fruit fly
(Drosophila melanogaster)
Insecta CG17221 37
  • 36 (a)
CG17221 35
  • 48.96 (n)
  • 38.07 (a)
CG17221 36
  • 32 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009178 35
  • 47.44 (n)
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea rad-8 35
  • 48.07 (n)
  • 37.29 (a)
rad-8 36
  • 37 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YIM1 36
  • 23 (a)
OneToOne
YIM1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G15090 35
  • 48.13 (n)
  • 35.96 (a)
rice
(Oryza sativa)
Liliopsida Os01g0753100 35
  • 46.71 (n)
  • 36.47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToOne
Species with no ortholog for RTN4IP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RTN4IP1 Gene

ENSEMBL:
Gene Tree for RTN4IP1 (if available)
TreeFam:
Gene Tree for RTN4IP1 (if available)

Paralogs for RTN4IP1 Gene

(1) SIMAP similar genes for RTN4IP1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RTN4IP1 Gene

genes like me logo Genes that share paralogs with RTN4IP1: view

No data available for Paralogs for RTN4IP1 Gene

Variants for RTN4IP1 Gene

Sequence variations from dbSNP and Humsavar for RTN4IP1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs898896 -- 106,615,287(+) CATAT(C/T)GGTAG intron-variant
rs898897 -- 106,615,544(+) ATCTC(A/G)GCTCA intron-variant
rs898898 -- 106,615,665(+) ACAGA(A/G)TGAAG intron-variant
rs898899 -- 106,615,683(+) TTCCC(A/G)GCAAG intron-variant
rs962476 -- 106,611,035(+) ACCCC(C/G)TTAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RTN4IP1 Gene

Variant ID Type Subtype PubMed ID
esv2732544 CNV Deletion 23290073
esv2499647 CNV Insertion 19546169
esv2658148 CNV Deletion 23128226

Variation tolerance for RTN4IP1 Gene

Residual Variation Intolerance Score: 73.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RTN4IP1 Gene

HapMap Linkage Disequilibrium report
RTN4IP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTN4IP1 Gene

Disorders for RTN4IP1 Gene

Relevant External Links for RTN4IP1

Genetic Association Database (GAD)
RTN4IP1
Human Genome Epidemiology (HuGE) Navigator
RTN4IP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RTN4IP1
genes like me logo Genes that share disorders with RTN4IP1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RTN4IP1 Gene

Publications for RTN4IP1 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. RTN4IP1 is down-regulated in thyroid cancer and has tumor-suppressive function. (PMID: 23393170) Rahbari R. … Kebebew E. (J. Clin. Endocrinol. Metab. 2013) 67
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67

Products for RTN4IP1 Gene

Sources for RTN4IP1 Gene

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