RTN4IP1 Gene
protein-coding GIFtS: 53
GCID: GC06M107065
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|
reticulon 4 interacting protein 1
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Aliases
for RTN4IP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Reticulon 4 Interacting Protein 11 2 | | NIMP1 2 3 5 | | NOGO-Interacting Mitochondrial Protein2 3 | | Reticulon-4-Interacting Protein 1, Mitochondrial2 |
Export aliases for RTN4IP1 gene to outside databasesPrevious GC identifers: GC06M106855 GC06M107041 GC06M107126 GC06M104468 |
Summaries
for RTN4IP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RTN4IP1:
This gene encodes a novel mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor ofregeneration following spinal cord injury. The interaction of reticulon 4 with mitochondrial proteins may provideinsight into the mechanisms for reticulon-induced inhibition of neurite growth. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RT4I1_HUMAN, Q8WWV3Function: Appears to be a potent inhibitor of regeneration following spinal cord injury
|
Genomic Views
for RTN4IP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RTN4IP1 gene promoter:
AML1a GATA-3 Nkx2-2 ARP-1 Nkx2-5 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RTN4IP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RTN4IP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q21RTN4IP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M107065: view genomic region
(about GC identifiers)
Start:
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107,018,903 bp from pter |
End:
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107,077,373 bp from pter |
Size:
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58,471 bases |
Orientation:
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minus strand |
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Proteins
for RTN4IP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RT4I1_HUMAN, Q8WWV3 (See
protein sequence)Recommended Name: Reticulon-4-interacting protein 1, mitochondrial precursor Size: 396 amino acids; 43590 Da
Subunit: Interacts with RTN4, UQCRC1 and UQCRC2 (By similarity)
Subcellular location: Mitochondrion
1 PDB 3D structure from  and Proteopedia  for RTN4IP1:2VN8 (3D)
Secondary accessions: Q8N9B3 Q8WZ66 Q9BRA4Alternative splicing: 3 isoforms: Q8WWV3-1 Q8WWV3-2 Q8WWV3-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RTN4IP1: NX_Q8WWV3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WWV3
RTN4IP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_116119.2
ENSEMBL proteins: ENSP00000358059 ENSP00000444261
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
RTN4IP1 for ontologies About GeneDecksing
RTN4IP1 Antibody Products:
Assay Products for RTN4IP1: |
Protein
Domains /
Families
for RTN4IP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RTN4IP1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q8WWV3ProtoNet protein and cluster: Q8WWV3 1 Blocks protein family: IPB002364 Quinone oxidoreductase/zeta-crystallin
UniProtKB/Swiss-Prot: RT4I1_HUMAN, Q8WWV3Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily |
Function
for RTN4IP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RT4I1_HUMAN, Q8WWV3Function: Appears to be a potent inhibitor of regeneration following spinal cord injury
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RTN4IP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RTN4IP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4IP1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
RTN4IP1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RTN4IP1:
|
Pathways & Interactions
for RTN4IP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RTN4IP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/8 Interacting proteins for RTN4IP1 (Q8WWV32, 3 ENSP000003580594) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
|
Drugs & Compounds
for RTN4IP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RTN4IP1
7 HMDB Compounds for RTN4IP1 About this table
Search CenterWatch for drugs/clinical trials and news about RTN4IP1 / RT4I1
|
Transcripts
for RTN4IP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RTN4IP1 gene: NM_032730.4 Unigene Cluster for RTN4IP1: Reticulon 4 interacting protein 1 Hs.155839 [show with all ESTs]Unigene Representative Sequence: NM_0327304 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369063 ENST00000498091 ENST00000493619 ENST00000539449(uc003prj.3 uc010kdd.3 uc003prk.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RTN4IP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RTN4IP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RTN4IP1 (NM_032730) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RTN4IP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTN4IP1 |
Additional cDNA sequence: AF439711.1 AK095207.1 AK313962.1 AY063761.1 BC006399.2 6 DOTS entries: DT.97839721 DT.97807828 DT.102839016 DT.95365740 DT.92424084 DT.95365742 24/57 AceView cDNA sequences (see all 57): AK095207 AA312336 CR601619 BF591333 BU622175 NM_032730 BU621544 BC006399 C02357 BF433676 BM922394 BG755358 BQ574215 BX431434 AY063761 CB132294 CB143318 AW403615 BX439330 CB986318 BQ936729 AI474619 BQ069356 CD105442
GeneLoc Exon Structure
|
Expression
for RTN4IP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RTN4IP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTAGATGAC
About this image
See RTN4IP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RTN4IP1
SOURCE GeneReport for Unigene cluster: Hs.155839
UniProtKB/Swiss-Prot: RT4I1_HUMAN, Q8WWV3Tissue specificity: Widely expressed in mitochondria-enriched tissues. Found in heart, muscle, kidney, liver, brain andplacenta
SABiosciences Custom PCR Arrays for RTN4IP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RTN4IP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RTN4IP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RTN4IP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTN4IP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4IP1 |
Orthologs
for RTN4IP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RTN4IP1 gene from 9/27 species (see all 27) About this table
ENSEMBL Gene Tree for RTN4IP1 (if available)
TreeFam Gene Tree for RTN4IP1 (if available) |
Paralogs
for RTN4IP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RTN4IP1 gene
1 SIMAP similar gene for RTN4IP1 using alignment to 2 protein entries: RT4I1_HUMAN (see all proteins):NIMP
RTN4IP1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for RTN4IP1
PGOHUM00000239863
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Genomic Variants
for RTN4IP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RTN4IP1 (107018903 - 107077373 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for RTN4IP1
8 CNVs: 81529 81527 93938 93940 99656 93937 93939 81528 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RTN4IP1 |
|
Disorders
/ Diseases
for RTN4IP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RTN4IP1 for disorders About GeneDecksing
OMIM gene information: 610502
OMIM disorders: --
2  diseases for RTN4IP1: About MalaCardsspinal cord injury alcoholism
Human Genome Epidemiology (HuGE) Navigator: RTN4IP1 (2 documents)
Export disorders for RTN4IP1 gene to outside databases
|
Publications
for RTN4IP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RTN4IP1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with RTN4IP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP). (PubMed id 12067236)1, 2 Hu W.-H....Bethea J.R. (2002)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth. (PubMed id 12160746)1 Domeniconi M....Filbin M. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for RTN4IP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RTN4IP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RTN4IP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RTN4IP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RTN4IP1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for RTN4IP1 gene:
Search GeneIP for patents involving RTN4IP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RTN4IP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | RTN4IP1 Proteins, Antibodies, CLIAs, and ELISAs |
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