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RTN4 Gene

protein-coding   GIFtS: 68
GCID: GC02M055199

Reticulon 4

  See RTN4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Reticulon 41 2     RTN4-B12
NOGO2 3 5     RTN4-B22
Neurite Outgrowth Inhibitor2 3     RTN4-C2
Neuroendocrine-Specific Protein C Homolog2 3     foocen2
NSP2 3     Human NogoA2
ASY2     My043 Protein2
NI220/2502     Neurite Growth Inhibitor 2202
NOGO-A2     Reticulon 52
NOGOC2     reticulon-42
NSP-CL2     Foocen3
Nbla002712     KIAA08863
Nbla105452     RTN-x3
Nogo-B2     Reticulon-53
Nogo-C2     Neuroendocrine-Specific Protein3
RTN-X2     Nogo Protein3
RTN4-A2     

External Ids:    HGNC: 140851   Entrez Gene: 571422   Ensembl: ENSG000001153107   OMIM: 6044755   UniProtKB: Q9NQC33   

Export aliases for RTN4 gene to outside databases

Previous GC identifers: GC02M055237 GC02M055386 GC02M055173 GC02M055110 GC02M054934


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RTN4 Gene:
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic
reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The
product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the
central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from
differential splicing and differential promoter usage and encoding different isoforms have been identified.
(provided by RefSeq, Jul 2008)

GeneCards Summary for RTN4 Gene:
RTN4 (reticulon 4) is a protein-coding gene. Diseases associated with RTN4 include amyotrophic lateral sclerosis, and schizophrenia. An important paralog of this gene is RTN3.

UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3
Function: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion
and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension
in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction
of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing
receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is
likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum,
after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein
processing

Gene Wiki entry for RTN4 (Reticulon 4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RTN4 gene promoter:
         POU2F1   POU2F1a   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 10): RTN4 promoter sequence
   Search Chromatin IP Primers for RTN4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RTN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.3   Ensembl cytogenetic band:  2p16.1   HGNC cytogenetic band: 2p14-p13

RTN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTN4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M055199:  view genomic region     (about GC identifiers)

Start:
55,199,325 bp from pter      End:
55,339,757 bp from pter
Size:
140,433 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3 (See protein sequence)
Recommended Name: Reticulon-4  
Size: 1192 amino acids; 129931 Da
Subunit: Binds to RTN4R. Interacts with Bcl-xl and Bcl-2. Isoform 2 binds to NGBR and RTN3. Isoform 2 and isoform
3 interact with BACE1 and BACE2. Interacts with RTN4IP1. Interacts with ATL1
Sequence caution: Sequence=AAD39920.1; Type=Frameshift; Positions=1149, 1156; Sequence=AAG43160.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAG43160.1; Type=Frameshift; Positions=684, 700;
Sequence=BAA74909.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for RTN4:
2G31 (3D)        2JV5 (3D)    
Secondary accessions: O94962 Q7L7Q5 Q7L7Q6 Q7L7Q8 Q8IUA4 Q96B16 Q9BXG5 Q9H212 Q9H3I3 Q9UQ42
Q9Y293 Q9Y2Y7 Q9Y5U6
Alternative splicing: 6 isoforms:  Q9NQC3-1   Q9NQC3-2   Q9NQC3-3   Q9NQC3-4   Q9NQC3-5   Q9NQC3-6   

Explore the universe of human proteins at neXtProt for RTN4: NX_Q9NQC3

Explore proteomics data for RTN4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1090, Lys1104, Lys1171
  • Modification sites at PhosphoSitePlus

  • See RTN4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_008939.1  NP_065393.1  NP_722550.1  NP_997403.1  NP_997404.1  

    ENSEMBL proteins: 
     ENSP00000378107   ENSP00000384471   ENSP00000349944   ENSP00000337838   ENSP00000322147  
     ENSP00000350365   ENSP00000378109   ENSP00000385650   ENSP00000397808   ENSP00000411628  
     ENSP00000384825   ENSP00000346465  
    Reactome Protein details: Q9NQC3

    RTN4 Human Recombinant Protein Products:

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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for RTN4
    OriGene Protein Over-expression Lysate for RTN4
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    Novus Biologicals RTN4 Proteins
    Novus Biologicals RTN4 Lysates
    Sino Biological Recombinant Protein for RTN4
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RTN4

     
    Search eBioscience for Proteins for RTN4 

     
    antibodies-online proteins for RTN4 (7 products) 

     
    antibodies-online peptides for RTN4

    RTN4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RTN4
    R&D Systems Antibodies for RTN4 (Nogo-A, Nogo-B, Nogo-C)
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    Novus Biologicals RTN4 Antibodies
    Abcam antibodies for RTN4
    Cloud-Clone Corp. Antibodies for RTN4
    ThermoFisher Antibodies for RTN4
    antibodies-online antibodies for RTN4 (115 products) 

    RTN4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RTN4
    Cloud-Clone Corp. CLIAs for RTN4
    Search eBioscience for ELISAs for RTN4 
    antibodies-online kits for RTN4 (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003388 Reticulon

    Graphical View of Domain Structure for InterPro Entry Q9NQC3

    ProtoNet protein and cluster: Q9NQC3

    1 Blocks protein domain: IPB003388 Reticulon

    UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3
    Domain: Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane
    domains, known as Nogo-66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the
    spreading of neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity)
    Similarity: Contains 1 reticulon domain


    Find genes that share domains with RTN4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RTN4_HUMAN, Q9NQC3
    Function: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion
    and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension
    in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction
    of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing
    receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is
    likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum,
    after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein
    processing

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11126360
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with RTN4           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Rtn4):
     cellular  mortality/aging  nervous system  normal 

    Find genes that share phenotypes with RTN4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RTN4: Rtn4tm1Schw Rtn4tm2.1Matl Rtn4tm2Matl

       genOway: Develop your customized and physiologically relevant rodent model for RTN4

    miRNA
    Products:
        
    miRTarBase miRNAs that target RTN4:
    hsa-mir-320a (MIRT044751), hsa-mir-30c-5p (MIRT047850), hsa-mir-132-3p (MIRT021845), hsa-mir-21-5p (MIRT000167), hsa-mir-183-5p (MIRT024991), hsa-mir-148b-3p (MIRT019491), hsa-mir-33a-5p (MIRT028224), hsa-mir-16-5p (MIRT001421), hsa-mir-34a-5p (MIRT025475), hsa-mir-101-3p (MIRT027341)

    Block miRNA regulation of human, mouse, rat RTN4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RTN4 (see all 19):
    hsa-miR-4318 hsa-miR-15a hsa-miR-503 hsa-miR-3692 hsa-miR-424 hsa-miR-195 hsa-miR-497* hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidRTN4 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat RTN4

    Gene Editing
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    OriGene ORF clones in mouse, rat for RTN4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): RTN4 (NM_020532)
    Sino Biological Human cDNA Clone for RTN4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RTN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTN4

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RTN4_HUMAN, Q9NQC3: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Anchored to the membrane
    of the endoplasmic reticulum through 2 putative transmembrane domains
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5
    plasma membrane4
    cytoskeleton2
    cytosol1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IDA11126360
    GO:0005783endoplasmic reticulum NAS11126360
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane ----
    GO:0030176integral component of endoplasmic reticulum membrane IDA10667797

    Find genes that share ontologies with RTN4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RTN4 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    Axonal growth inhibition (RHOA activation)0.00
    p75NTR regulates axonogenesis0.00
    2Signaling by FGFR
    Signalling by NGF0.71
    3Signaling by GPCR
    Signal Transduction0.58
    4Cell adhesion Integrin mediated cell adhesion and migration
    Development MAG dependent inhibition of neurite outgrowth0.46
    5Spinal Cord Injury
    Spinal Cord Injury


    Find genes that share SuperPaths with RTN4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RTN4
        NgR-p75(NTR)-Mediated Signaling

    1 GeneGo (Thomson Reuters) Pathway for RTN4
        Development MAG-dependent inhibition of neurite outgrowth

    2 BioSystems Pathways for RTN4
        Spinal Cord Injury
    p75(NTR)-mediated signaling


    1 Reactome Pathway for RTN4
        Axonal growth inhibition (RHOA activation)


        Pathway & Disease-focused RT2 Profiler PCR Arrays including RTN4: 
              Neurogenesis in human mouse rat
              Nephrotoxicity in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RTN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RTN4 (Q9NQC31, 2, 3 ENSP000003378384) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000236693P044402, 3, ENSP000004141964MINT-8258153 I2D: score=2 STRING: ENSP00000414196
    ENSG00000237710P044402, 3, ENSP000003892884MINT-8258153 I2D: score=2 STRING: ENSP00000389288
    ENSG00000215048P044402, 3MINT-8258153 I2D: score=2 
    ENSG00000226826P044402, 3MINT-8258153 I2D: score=2 
    ENSG00000230763P044402, 3MINT-8258153 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006915apoptotic process NAS11126360
    GO:0007399nervous system development ----
    GO:0007413axonal fasciculation ISS--
    GO:0021801cerebral cortex radial glia guided migration ISS--

    Find genes that share ontologies with RTN4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RTN4

    1 Novoseek inferred chemical compound relationship for RTN4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ddvp 58 1 17029193 (1)



    Find genes that share compounds with RTN4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RTN4 gene (5 alternative transcripts): 
    NM_007008.2  NM_020532.4  NM_153828.2  NM_207520.1  NM_207521.1  

    Unigene Cluster for RTN4:

    Reticulon 4
    Hs.637850  [show with all ESTs]
    Unigene Representative Sequence: NM_020532
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394609(uc002ryc.3) ENST00000405240 ENST00000357376(uc002ryd.3)
    ENST00000337526(uc002rye.3) ENST00000317610(uc002ryg.3) ENST00000357732(uc002ryf.3)
    ENST00000394611 ENST00000404909 ENST00000486085 ENST00000491592 ENST00000485749
    ENST00000438462 ENST00000427710 ENST00000461004 ENST00000402434 ENST00000354474

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RTN4 (see all 19):
    hsa-miR-4318 hsa-miR-15a hsa-miR-503 hsa-miR-3692 hsa-miR-424 hsa-miR-195 hsa-miR-497* hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidRTN4 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat RTN4

    Additional mRNA sequence: 

    AB015639.1 AB020693.1 AB040462.1 AB040463.1 AB073351.1 AB073359.1 AF063601.1 AF077050.1 
    AF087901.1 AF125103.1 AF132047.1 AF132048.1 AF148537.1 AF148538.1 AF177332.1 AF320999.1 
    AF333336.1 AJ251383.1 AJ251384.1 AJ251385.1 AK075039.1 AK098385.1 AK129806.1 AK130812.1 
    AK172726.1 AK302741.1 AY102276.1 AY102277.1 AY102278.1 AY102279.1 AY123245.1 AY123246.1 
    AY123247.1 AY123248.1 AY123249.1 AY123250.1 BC001035.2 BC007109.1 BC010737.1 BC012619.1 
    BC014366.1 BC016165.1 BC026788.1 BC068991.1 BC071848.1 BC150182.1 BC152425.1 BC152555.1 
    DQ778739.1 

    Selected DOTS entries (see all 70):

    DT.87018236  DT.92057768  DT.91855184  DT.100039375  DT.97862663  DT.95148397  DT.100889622  DT.97776594 
    DT.100039374  DT.100889645  DT.100039372  DT.121021010  DT.100889631  DT.420660  DT.100889638  DT.100889649 
    DT.100889641  DT.100889621  DT.121021012  DT.408266  DT.95128616  DT.95329023  DT.100889636  DT.102838873 

    Selected AceView cDNA sequences (see all 1507):

    BM666337 AU104978 BU684302 AI217084 CB108617 AW673265 AA058672 CN483287 
    CB133824 AA370615 CD723962 AK130812 CB148622 AU104981 BM709363 T34690 
    R96423 AA331600 AI828700 AA307342 BE302112 BU952509 BX439214 N73666 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RTN4 (see all 18)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d ^ 16 ^
    SP1:        -     -     -     -     -     -     -     -     -     -                 -     -     -                       -           -     -                     
    SP2:                          -     -     -     -     -     -     -                 -     -     -                       -           -     -                     
    SP3:                                      -     -     -     -     -                 -     -     -                       -           -     -                     
    SP4:                                                  -     -     -                 -     -     -                       -           -     -                     
    SP5:                                                        -     -                 -     -     -                       -           -     -                     

    ExUns: 17a · 17b · 17c · 17d
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for RTN4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    RTN4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGCCACA
    RTN4 Expression
    About this image


    RTN4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebellum
     
     Eye (Sensory Organs)
             Retina
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    RTN4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RTN4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.637850

    UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3
    Tissue specificity: Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal
    muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and
    adipocytes. Isoform 4 is testis-specific

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RTN4: 
              Neurogenesis in human mouse rat
              Nephrotoxicity in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RTN4
    OriGene qSTAR qPCR primer pairs in human, mouse for RTN4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RTN4
    QuantiTect SYBR Green Assays in human, mouse, rat RTN4
    QuantiFast Probe-based Assays in human, mouse, rat RTN4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for RTN4 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rtn41 , 5 reticulon 41, 5 83.56(n)1
    77.72(a)1
      11 (16.79 cM)5
    685851  NM_194054.31  NP_918943.11 
     296929475 
    chicken
    (Gallus gallus)
    Aves LOC1017495791 reticulon-4-like 60.49(n)
    44.32(a)
      101749579  XM_004940171.1  XP_004940228.1 
    lizard
    (Anolis carolinensis)
    Reptilia RTN46
    reticulon 4
    45(a)
    1 ↔ 1
    1(263834474-263901082)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684892 hypothetical protein MGC68489 78.12(n)    BC059960.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.247182 Transcribed sequence with weak similarity to protein more 74.33(n)    57038777 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rtnl16
    Rtnl26
    (see all 3)
    Rtnl2
    (see all 3)
    27(a)
    22(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2L(4992808-5009720)
    3R(3354586-3355963)
    worm
    (Caenorhabditis elegans)
    Secernentea ret-16
    Protein RET-1, isoform c
    7(a)
    1 → many
    V(14829177-14847312) WBGene00004336


    ENSEMBL Gene Tree for RTN4 (if available)
    TreeFam Gene Tree for RTN4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RTN4 gene
    RTN32  RTN12  RTN22  
    6 SIMAP similar genes for RTN4 using alignment to 10 protein entries:     RTN4_HUMAN (see all proteins):
    NOGOC    Nbla10545    Nbla00271    RTN3    RTN1    RTN2

    Find genes that share paralogs with RTN4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for RTN4 (see all 2140)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359044
    A colorectal cancer sample4--see VAR_0359042 L V mis40--------
    rs1505009551,2
    C--55065245(+) CATGTC/TTGCCT 5 -- ds50010--------
    rs774080681,2
    C,F--55065324(+) CGATTA/GATGAT 5 -- ds50011Minor allele frequency- G:0.09WA 118
    rs787088271,2
    C,F--55065441(+) CTGCAC/GTGTAT 5 -- ds50011Minor allele frequency- G:0.01NA 120
    rs8871,2
    C,F,O,A,H--55065457(-) TTAACT/CCACAT 5 -- ds500135Minor allele frequency- C:0.23MN EA NA NS WA CSA 5199
    rs800983851,2
    C,F--55065479(+) ATGAAT/ATTATT 5 -- ds50011Minor allele frequency- A:0.06WA 118
    rs1910984871,2
    --55065501(+) AAACAC/TATCAC 5 -- ds50010--------
    rs38390541,2
    C--55065560(-) AACAA-/AAGTCAA 5 -- ds50010--------
    rs1832858611,2
    --55065573(+) CCACAA/GTAAAC 5 -- ds50010--------
    rs1388756101,2
    C--55065575(+) ACAGT-/AAAC  
            
    AAACA
    5 -- ds50010--------
    rs1396285721,2
    --55065612(+) AAAACA/CCTTCT 5 -- ds50010--------
    rs2014297201,2
    C--55065616(+) CCTTC-/TATAAAA 5 -- ds50010--------
    rs25885101,2
    C,F,O,A,H--55065637(-) CCAGCG/AAATGG 5 -- ds500128Minor allele frequency- A:0.43EA NA NS WA 4216
    rs1434372581,2
    --55065693(+) TCATGA/GAATGA 5 -- ds50010--------
    rs1121056501,2
    C--55065740(+) TGATAT/CTTTGC 5 -- ut311Minor allele frequency- C:0.00CSA 1
    rs150291,2
    C,F,H--55065831(+) AATAAT/ATTCTT 5 -- ut3112Minor allele frequency- A:0.16MN NS EA NA WA 1750
    rs1429557361,2
    C--55065858(+) ATTTG-/CAAA  
            
    CAAAC
    5 -- ut310--------
    rs1127856821,2
    C--55065888(+) ATTAGA/GTTCAG 5 -- ut312Minor allele frequency- G:0.04CSA WA 120
    rs150281,2
    C,F,O,H--55065899(+) TCCATA/CGATTC 5 -- ut31 ese320Minor allele frequency- C:0.07MN NA NS EA WA 2064
    rs58313311,2
    C--55065946(+) ATTGA-/TGTTGTTG 5 -- cds10--------
    rs772256051,2
    C--55065946(+) AATTGT/ATGTTG 5 -- ut311Minor allele frequency- A:0.50CSA 2
    rs346067201,2
    C--55065947(+) TTGAT-/TGTGTTGG 5 -- cds10--------
    rs1871150761,2
    --55065960(+) TTCTAC/TGTGTG 5 -- ut310--------
    rs75732861,2
    C--55066153(+) TTATAC/TTGGCA 5 -- ut310--------
    rs1920296831,2
    --55066182(+) GTCACA/TATACA 5 -- ut310--------
    rs170465201,2
    C,F,H--55066237(+) CGGTAT/CGATCT 5 -- ut31 ese314Minor allele frequency- C:0.03NA NS EA WA 1628
    rs1462721361,2
    C--55066288(+) CTACAC/TGGACC 5 -- ut310--------
    rs2013481661,2
    C--55066289(+) TACACA/GGACCA 5 -- ut310--------
    rs1393484981,2
    C--55066310(+) ACAAAC/TTGAAA 5 -- ut310--------
    rs1999761851,2
    C--55066337(+) TTTTTC/TTAGCT 5 -- ut310--------
    rs1997229401,2
    C--55066436(+) TCAGAC/TAGATA 5 -- ut310--------
    rs1440897191,2
    C--55066459(+) GATTAA/C/TGGTTT 10 -- ut310--------
    rs75886871,2
    C,H--55066475(+) CATACA/GTAGCA 5 -- ut31 ese34Minor allele frequency- G:0.00NS EA 418
    rs115498971,2
    H--55066481(+) TAGCAG/ACTTAC 5 -- ut31 ese34Minor allele frequency- A:0.00NS EA 420
    rs1884628871,2
    C--55066498(+) TAAGAA/TGATGA 5 -- ut310--------
    rs1925499591,2
    C--55066572(+) AACAAC/TGATCT 5 -- ut310--------
    rs2016502641,2
    C--55066604(+) AAGGTC/TCGTTC 5 -- ut310--------
    rs18019111,2
    C--55066606(-) AAGAAC/TGAACC 5 -- ut310--------
    rs1822491221,2
    C--55066627(+) CCCCCA/GTATAA 5 -- ut310--------
    rs1452693751,2
    C--55066689(+) TTTCAC/TTCAGC 10 E syn10--------
    rs2022458541,2
    C--55066699(+) CTTTGC/TGCTTC 10 H R mis10--------
    rs2000000511,2
    --55066700(+) TTTGCA/GCTTCA 10 R C mis10--------
    rs1865562851,2
    C--55066741(+) TGAAAA/TAGTCA 5 -- int10--------
    rs2012278701,2
    C--55066749(+) TCAATA/GTAAAT 5 -- int10--------
    rs1491570251,2
    C--55066785(+) AATACC/TATCTT 5 -- int10--------
    rs37391041,2
    H--55066824(-) TTTATT/CGTATT 5 -- int14Minor allele frequency- C:0.00NS EA 420
    rs1911891481,2
    --55066931(+) GAAACA/GAATGG 5 -- int10--------
    rs1397256671,2
    C--55066950(+) TAGAA-/AAAC  
            
    AAACA
    5 -- int10--------
    rs1997226481,2
    C--55067053(+) GCACAC/TCTTAT 5 -- int10--------
    rs2007982381,2
    C--55067160(+) AAAGAA/GAGGTA 5 -- int10--------
    rs1848185041,2
    C--55067178(+) ATTATG/TACCGT 5 -- int10--------
    rs1995880341,2
    C--55067182(+) TTACCA/GTTGCT 5 -- int10--------
    rs22551121,2
    C,F,O,H--55067194(-) ATAAGA/CTTCTT 5 -- int124Minor allele frequency- C:0.46EA NA NS WA 3964
    rs1903458341,2
    C--55067289(+) CATCCA/GTAAAT 5 -- int10--------
    rs1932009631,2
    C--55067320(+) CTCTAC/TTCTGA 5 -- int10--------
    rs1122511361,2
    C--55067349(+) AAATTA/G/TCCTGA 5 -- spd11CSA 1
    rs2010086271,2
    C--55067368(+) ATAAAC/TAACAG 10 I V mis10--------
    rs22550261,2
    C,F,A,H--55067432(-) ATTCCA/GTTCTT 5 -- int119Minor allele frequency- G:0.20EA NS NA WA CSA EU 3458
    rs1121571941,2
    F--55067463(+) TCAAAAAA/-CTATT 5 -- int11Minor allele frequency- -:0.50CSA 4
    rs1849863391,2
    --55067485(+) ACTCAA/GGATAA 5 -- int10--------
    rs118920151,2
    C,F,H--55067755(+) ACTAAG/CGTAGC 5 -- int17Minor allele frequency- C:0.06NS EA WA NA 542
    rs1898847331,2
    C--55067804(+) AAAGAA/GAATAC 5 -- int10--------
    rs1422804761,2
    C--55067815(+) AACCTC/TAAACT 5 -- int10--------
    rs1811441221,2
    --55067870(+) AATGGC/GACGAT 5 -- int10--------
    rs1854051101,2
    --55067974(+) CCAGCC/TAATTT 5 -- int10--------
    rs1512372911,2
    --55068122(+) TTCATC/TCCCTA 5 -- int10--------
    rs2015479751,2
    C--55068201(+) TTTTCA/TTCCCA 5 -- int10--------
    rs2001413511,2
    C--55068216(+) CTTTGG/TAGACT 5 -- int10--------
    rs2016341131,2
    --55068322(+) CATTAA/TAAACA 5 -- int10--------
    rs1884014051,2
    C--55068342(+) TAAAGC/TTTCTT 5 -- int10--------
    rs1418592041,2
    C--55068345(+) AGTTTC/TTTAAT 5 -- int10--------
    rs1181302371,2
    F--55068393(+) CAAAAG/TGCATA 5 -- int11Minor allele frequency- T:0.01EA 120
    rs1808192391,2
    --55068404(+) CAACTG/TGAAGA 5 -- int10--------
    rs1876541781,2
    --55068519(+) CACTAC/TCAAGT 5 -- int10--------
    rs1919653091,2
    --55068648(+) ATTGAC/TTTCAA 5 -- int10--------
    rs1121546041,2
    F--55068659(+) AGTATG/AAACTA 5 -- int12Minor allele frequency- A:0.02CSA WA 120
    rs1837040471,2
    --55068826(+) GAATTC/TTGTTA 5 -- int10--------
    rs75702981,2
    C,F,A,H--55068849(+) CATCAG/ATTCCT 5 -- int111Minor allele frequency- A:0.22NS EA NA WA CSA 800
    rs1471255351,2
    C--55068899(+) ATCACC/TTTGAC 5 -- int10--------
    rs1385332241,2
    --55069033(+) TTCTCC/TGTGAA 5 -- int10--------
    rs25885221,2
    C,F,H--55069043(-) TGTCTA/GGCTCT 5 -- int120Minor allele frequency- G:0.15NS EA NA WA CSA 1207
    rs727954211,2
    C,F--55069154(+) CCCACA/GCTATA 5 -- int11Minor allele frequency- G:0.03NA 120
    rs1144490131,2
    F--55069197(+) TTTGCT/CAACCC 5 -- int11Minor allele frequency- C:0.02WA 118
    rs1425711571,2
    --55069217(+) AGCATA/CTATCT 5 -- int10--------
    rs749389211,2
    F--55069239(+) TTAAAC/TGAACT 5 -- int11Minor allele frequency- T:0.03WA 118
    rs1502385461,2
    --55069271(+) ATTAAA/TTAAGC 5 -- int10--------
    rs727954221,2
    C--55069289(+) CATTAC/GTAAGC 5 -- int10--------
    rs1865904671,2
    --55069303(+) TTTATC/TACAGC 5 -- int10--------
    rs1901815181,2
    --55069322(+) ACACTG/TTGGAT 5 -- int10--------
    rs1494740811,2
    --55069334(+) ACTCTA/TCCAAG 5 -- int10--------
    rs1826246791,2
    --55069343(+) AGCAAC/TAGTTC 5 -- int10--------
    rs1869429971,2
    --55069379(+) CTAACG/TGAATT 5 -- int10--------
    rs1438758051,2
    --55069434(+) GTCAAA/TTGAAA 5 -- int10--------
    rs1914379891,2
    C--55069548(+) TTATAA/GACTCC 5 -- int10--------
    rs729108701,2
    C,F--55069601(+) ACTATA/GGAGTA 5 -- int14Minor allele frequency- G:0.11WA CSA 124
    rs1825579961,2
    --55069709(+) TTAACA/GTGACA 5 -- int10--------
    rs1482063351,2
    --55069720(+) GAAGAC/TAGTAA 5 -- int10--------
    rs37547671,2
    C,F,H--55069722(-) TGTTAC/GTATCT 5 -- int16Minor allele frequency- G:0.03EA NS 2044
    rs1139028981,2
    C--55069846(+) AATGTC/TACTTG 5 -- int12Minor allele frequency- T:0.03CSA WA 120
    rs1890680191,2
    --55069867(+) AACACC/TTCCTA 5 -- int10--------
    rs783272941,2
    --55070042(+) GCTGTA/GGCCAT 5 -- int10--------
    rs1930209641,2
    C--55070128(+) ATGTTC/GAGAAA 5 -- int10--------
    rs770653391,2
    C,F--55070134(+) AGAAAA/CCTGAA 5 -- int11Minor allele frequency- C:0.03WA 118
    rs25885211,2
    C,F,O,A,H--55070325(-) GAGCAG/CCCTGT 5 -- int114Minor allele frequency- C:0.41NA NS EA CSA WA 928
    rs1462838031,2
    --55070329(+) GCTGCC/TCTCAT 5 -- int10--------
    rs25807651,2
    C,F,O,A,H--55070422(+) AGCTTA/CTCTCT 5 -- int124Minor allele frequency- C:0.46EA NA NS CSA WA 3944
    rs801594821,2
    F--55070437(+) TGCACA/GGTATC 5 -- int12Minor allele frequency- G:0.05CSA WA 120
    rs46720021,2
    H--55070519(+) CATCTG/AGTTTA 5 -- int14Minor allele frequency- A:0.00NS EA 420
    rs1425847811,2
    --55070525(+) GTTTAC/TCTTTC 5 -- int10--------
    rs1505529291,2
    --55070547(+) TAAGAA/GAATTA 5 -- int10--------
    rs67055191,2
    C,F,A--55070559(+) ATTCAC/TTGTGT 5 -- int14Minor allele frequency- T:0.28WA CSA NA 242
    rs1143092531,2
    C,F--55070613(+) AATTTG/AGGGGA 5 -- int11Minor allele frequency- A:0.06WA 118
    rs1853496331,2
    C--55070626(+) GGGTAC/TCTTTA 5 -- int10--------
    rs1416181901,2
    C--55070658(+) TTAGT-/AAAGAT 5 -- int10--------
    rs1898821901,2
    --55070687(+) GTTCTC/GACCAT 5 -- int10--------
    rs1397849631,2
    --55070745(+) TGTGTC/GTCCTT 5 -- int10--------
    rs1497859251,2
    --55070793(+) ATATCC/TCCAGC 5 -- int10--------
    rs1920765841,2
    --55070800(+) CAGCCC/TACTTC 5 -- int10--------
    rs1843010131,2
    --55070804(+) CCACTG/TCCTTC 5 -- int10--------
    rs29688041,2
    C,F,O,A,H--55070892(-) AAAATG/CTAGCT 5 -- int122Minor allele frequency- C:0.30NA NS EA WA CSA 1354
    rs1886488031,2
    --55070904(+) GTGTTA/CTTCTG 5 -- int10--------
    rs118991971,2
    C,F,H--55070931(+) AGCTCA/GGGCCG 5 -- int11Minor allele frequency- G:0.18WA 118
    rs2003892941,2
    C--55070952(-) AGGAAA/GAAAAA 5 -- int10--------
    rs1810760111,2
    --55070986(+) GTTCTC/GGAACA 5 -- int10--------
    rs37693271,2
    C,F,H--55071001(-) GAGGCG/ACAACT 5 -- int15Minor allele frequency- A:0.02NS EA 540
    rs1857792351,2
    --55071054(+) TAGTCC/TCTAAA 5 -- int10--------
    rs1906868221,2
    C--55071125(+) AGAAGC/GCTCAG 5 -- int10--------
    rs727954241,2
    C--55071134(+) AGTCAC/GACTCA 5 -- int10--------
    rs1170101731,2
    F--55071140(+) ACTCAA/GTTAGC 5 -- int11Minor allele frequency- G:0.02EA 120
    rs25807661,2
    C,F,H--55071196(+) AATTGG/CGGGTG 5 -- int116Minor allele frequency- C:0.08NS EA NA WA CSA 786
    rs1819801131,2
    --55071198(+) TTGCGA/GGTGGG 5 -- int10--------
    rs1399115351,2
    --55071261(+) GATTTC/TTGCCA 5 -- int10--------
    rs37693261,2
    C,F,H--55071291(-) AGCAAC/AGATCA 5 -- int15Minor allele frequency- A:0.02NS EA 540
    rs1453408161,2
    --55071369(+) CAAACA/GGAATA 5 -- int10--------
    rs101886021,2
    H--55071388(+) GAATTT/AAAAAG 5 -- int14Minor allele frequency- A:0.00NS EA 420
    rs1477521161,2
    --55071427(+) TATTCA/GCCCAA 5 -- int10--------
    rs1872746541,2
    C--55071485(+) CACACC/TGGTGT 5 -- int10--------
    rs25885201,2
    C,F,H--55071488(-) TAAACG/ACCGGT 5 -- int121Minor allele frequency- A:0.10EA NS NA WA CSA 2430
    rs25885191,2
    C,F,A,H--55071520(-) TAACCG/AAACTC 5 -- int126Minor allele frequency- A:0.33EA NS NA WA CSA 3962
    rs1151142281,2
    C,F--55071586(+) GGCAAT/GAAGCA 5 -- int11Minor allele frequency- G:0.03WA 118
    rs1167214141,2
    C,F--55071643(+) TTCTGA/CGGAAG 5 -- int11Minor allele frequency- C:0.02WA 118
    rs1906281831,2
    C--55071653(+) GATGGC/TTTCAC 5 -- int10--------
    rs29191251,2
    C,F,O,H--55071658(+) TTTCAA/CATGGA 5 -- int126Minor allele frequency- N:0.00NS EA NA WA CSA 1880
    rs1426057781,2
    C--55071719(+) CACTCC/TGGGAG 5 -- int10--------
    rs1815117451,2
    --55071774(+) CTGGCC/TAACTT 5 -- int10--------
    rs1856546691,2
    --55071899(+) AAAGGC/TTGCAG 5 -- int10--------
    rs1899220111,2
    --55071912(+) AGCCTA/CAGATC 5 -- int10--------
    rs1120939801,2
    C--55071918(+) AGATCA/GCACCA 5 -- int10--------
    rs1828882961,2
    --55071922(+) CGCACC/TACCGC 5 -- int10--------
    rs1874875501,2
    C--55071925(+) ACCACC/TGCCCT 5 -- int10--------
    rs1512887931,2
    --55071937(+) CAGCCC/TGGGTG 5 -- int10--------
    rs1923872781,2
    --55071950(+) ACAGCG/TAGACT 5 -- int10--------
    rs343028891,2
    C--55071963(+) CTCCAA/-AAAAA 5 -- int11Minor allele frequency- -:0.00NA 2
    rs2020006011,2
    --55071977(+) AAAAA-/GAAAAA 5 -- int10--------
    rs1405506891,2
    --55072022(+) TGTAGA/CTATAA 5 -- int10--------
    rs1501248711,2
    --55072172(+) GAAATC/GAGAGT 5 -- int10--------
    rs1840126781,2
    --55072238(+) TCATAC/TAAAAT 5 -- int10--------
    rs1878399301,2
    --55072256(+) ATTCCA/GATAAA 5 -- int10--------
    rs1923231601,2
    --55072283(+) ATTTTA/TAAAAA 5 -- int10--------
    rs67392101,2
    C,F,H--55072340(+) ACTGGG/AGCTAT 5 -- int119Minor allele frequency- A:0.15NA NS EA WA CSA 938
    rs739365121,2
    C,F--55072398(+) AAATCC/TGTTTA 5 -- int12Minor allele frequency- T:0.17WA 120
    rs768850981,2
    C--55072452(+) AGAATG/AGGAAT 5 -- int13Minor allele frequency- A:0.11WA NA 240
    rs1385785081,2
    --55072507(+) TTCCCC/TACCAG 5 -- int10--------
    rs1415628161,2
    --55072540(+) AGTAAA/TACAGT 5 -- int10--------
    rs1452108201,2
    --55072571(+) ATTAAC/GATTTT 5 -- int10--------
    rs1845324511,2
    --55072607(+) AGACAA/GGGTCT 5 -- int10--------
    rs1871944221,2
    C--55072642(+) CAGTGG/TTATGA 5 -- int10--------
    rs1916540761,2
    --55072722(+) GACTAA/CAGGCA 5 -- int10--------
    rs1176460471,2
    C,F--55072737(+) CGACCA/TTGGCT 5 -- int11Minor allele frequency- T:0.05EA 120
    rs1845495461,2
    --55072786(+) TCACAA/GTGTTG 5 -- int10--------
    rs10559801,2
    H--55072961(-) GAGACT/CTCTGT 5 -- int16Minor allele frequency- C:0.00MN NS EA NA 606
    rs1138333841,2
    C,F--55072991(+) CAAGCG/ATTTTT 5 -- int11Minor allele frequency- A:0.50CSA 2
    rs1165396691,2
    F--55073007(+) AAAGCA/TAAGTG 5 -- int11Minor allele frequency- T:0.02WA 118
    rs1168478921,2
    C,F--55073075(+) CTGTAT/CATTCA 5 -- int11Minor allele frequency- C:0.05EA 120
    rs1179633131,2
    F--55073170(+) ACAAGG/ATTTAT 5 -- int11Minor allele frequency- A:0.01EA 120
    rs1892761061,2
    C--55073177(+) TTATCA/GTTTAT 5 -- int10--------
    rs1495257301,2
    --55073330(+) GTGCTA/TACATG 5 -- int10--------
    rs1808255351,2
    --55073353(+) TTACTC/TATTTG 5 -- int10--------
    rs739365131,2
    C,F--55073455(+) AAGTAC/TGTTTT 5 -- int14Minor allele frequency- T:0.12WA CSA NA 241
    rs1440422601,2
    --55073545(+) TAAGAA/TACAAC 5 -- int10--------
    rs1857105521,2
    --55073565(+) AGAAAA/GGAAAT 5 -- int10--------
    rs1893079521,2
    --55073718(+) AGAAAC/TTAAAA 5 -- int10--------
    rs1815618021,2
    --55073853(+) AACATG/TTTCTC 5 -- int10--------
    rs1857065161,2
    C--55074070(+) TAGACA/GTATAG 5 -- int10--------
    rs31981231,2
    C,F,O,H--55074085(-) TAGCAG/ATGAAG 5 -- int120Minor allele frequency- A:0.21NA NS EA WA CSA 2348
    rs1486759431,2
    C--55074148(+) TTGAAC/TCTATA 5 -- int10--------
    rs1901671491,2
    --55074238(+) ACTACC/TAAATT 5 -- int10--------
    rs1811799231,2
    --55074265(+) CTGTTG/TGAAGC 5 -- int10--------
    rs29191261,2
    C,F,A,H--55074287(+) ACTTAT/CAGACA 5 -- int115Minor allele frequency- C:0.14NS EA NA WA CSA 758
    rs1115802481,2
    C,F--55074308(+) TCAGTC/AAATTC 5 -- int11Minor allele frequency- A:0.50CSA 2
    rs1864286361,2
    --55074381(+) TGTTCC/TACCCT 5 -- int10--------
    rs1909219841,2
    --55074427(+) AATAGG/TAACTG 5 -- int10--------
    rs37693231,2
    C,F,H--55074462(-) GAAATA/GGAACC 5 -- int16Minor allele frequency- G:0.02EA NS 2044
    rs1508598491,2
    --55074520(+) CAAGCA/GTGCCA 5 -- int10--------
    rs1399519431,2
    --55074554(+) ATTTAA/CAGACT 5 -- int10--------
    rs1828177501,2
    --55074620(+) CTATAC/TGAAAG 5 -- int10--------
    rs1880867561,2
    --55074748(+) AAGCCC/TAGAGA 5 -- int10--------
    rs1908577311,2
    C--55074794(+) TTATAA/CAGGCT 5 -- int10--------
    rs1830775511,2
    --55074864(+) TTCAGA/TAATTG 5 -- int10--------
    rs1166302141,2
    F--55075190(+) GCAAGG/CTGAGA 5 -- int11Minor allele frequency- C:0.02WA 118
    rs621348181,2
    C--55075234(+) AACTAA/CAGAAA 5 -- int12Minor allele frequency- C:0.06NA 122
    rs25885131,2
    C,F,O,H--55075258(+) TACCAA/GTTGAA 5 -- int118Minor allele frequency- G:0.16NA NS EA WA CSA 928
    rs616215491,2
    C,F--55075259(+) ACCAGT/CTGAAG 5 -- int13Minor allele frequency- C:0.11WA NA 240
    rs1476575121,2
    --55075289(+) AATATG/TAAATC 5 -- int10--------
    rs1410282491,2
    --55075298(+) TCTTAC/TCTAGA 5 -- int10--------
    rs1444216261,2
    C--55075343(+) GTACA-/TATGAATCACAT
    ACAAGCTAAGAAAC
    TAAGT
    5 -- int10--------
    rs2014110281,2
    --55075427(+) ATTCC-/GATT  
            
    AATTT
    5 -- int10--------
    rs1998182271,2
    --55075428(+) TTCCG-/ATTA  
            
    ATTTC
    5 -- int10--------
    rs1498651061,2
    --55075532(+) GGCTGC/GAATGC 5 -- int10--------
    rs25885141,2
    C,A,H--55075569(+) CCTCTA/GCCTCC 5 -- int12Minor allele frequency- G:0.00NA 4
    rs75765041,2
    C,F--55075618(+) tagctG/Aggatt 5 -- int11Minor allele frequency- A:0.50CSA 2
    rs1437530521,2
    C--55075627(+) TTACAA/GGCATG 5 -- int10--------
    rs717953971,2
    C--55075672(+) AGAGA-/CGG   
       GGTTT
    CTCCA
    5 -- int10--------
    rs717721341,2
    C--55075673(+) GAGAC-/GGG   
       GTTTC
    TCCAT
    5 -- int10--------
    rs754791391,2
    C--55075797(+) TGATTC/TATAAC 5 -- int10--------
    rs1874105361,2
    --55075832(+) AGGACG/TCTCTG 5 -- int10--------
    rs1930611871,2
    --55075963(+) GAATAC/TAGAAG 5 -- int10--------
    rs2004531211,2
    C--55076087(+) CCTGAA/GTTCCT 10 L F mis10--------
    rs1426229231,2
    C--55076098(+) TTATCG/ATGCAG 10 /T /M mis11Minor allele frequency- A:0.00NA 4548
    rs1408018681,2
    C--55076100(+) ATCGTG/ACAGTT 10 /C syn11Minor allele frequency- A:0.00NA 4548
    rs1477808491,2
    C,F--55076158(+) ATATAC/G/TCAACT 15 D A G mis11NA 4550
    rs1882206481,2
    C--55076215(+) ACTAAC/TTGGAG 5 -- int10--------
    rs759165741,2
    F--55076378(+) ACAGAA/GAAAGC 5 -- int11Minor allele frequency- G:0.01WA 118
    rs1129978911,2
    C,F--55076416(+) GCTTGT/AATCTG 5 -- int11Minor allele frequency- A:0.50CSA 2
    rs101927711,2
    H--55076427(+) atgctC/Ttgcca 5 -- int14Minor allele frequency- T:0.00NS EA 420
    rs1402693041,2
    --55076498(+) ATTTAC/TAAAGT 5 -- int10--------
    rs1116519661,2
    C--55076536(+) AAAGTG/-CCTAA 5 -- int11Minor allele frequency- -:0.50CSA 2
    rs1925062211,2
    --55076552(+) CTGAGC/TACAAG 5 -- int10--------
    rs2001046341,2
    C--55076607(-) TTTAAA/GAAAAA 5 -- int10--------
    rs1117012721,2
    F--55076663(+) TTCATC/TTCCAA 5 -- int11Minor allele frequency- T:0.50CSA 2
    rs1378576061,2
    C--55076702(+) GGGGAA/CATTGT 5 -- int10--------
    rs1416271161,2
    --55076712(+) TTCAAC/TATGTC 5 -- int10--------
    rs729108761,2
    C--55076808(+) CATACC/TGAGAT 5 -- int10--------
    rs1426721561,2
    C--55076850(+) TTGGT-/AATA  
            
    AATAA
    5 -- int10--------
    rs672599501,2
    C--55076880(+) ATAAAT/AAAAAA 5 -- int13Minor allele frequency- A:0.12NA EA 242
    rs2004181541,2
    C--55076883(+) ATAAA-/T/TAAA
            
    AATAC
    5 -- int10--------
    rs174186751,2
    C,F,H--55076997(+) CTGAGT/CGTTCC 5 -- int122Minor allele frequency- C:0.20NA NS EA WA CSA 2484
    rs791102291,2
    C--55077177(+) CACTTA/TCTATT 5 -- int10--------
    rs573970601,2
    C,F--55077186(+) TTTACG/AAGCTG 5 -- int11Minor allele frequency- A:0.50CSA 2
    rs25885151,2
    C,F,O,A,H--55077248(+) CATTCT/CGTCAG 5 -- int132Minor allele frequency- C:0.15NA NS EA WA CSA 2816
    rs1836141761,2
    --55077332(+) GACCTA/GCCACT 5 -- int10--------
    rs1127920871,2
    C,F--55077516(+) AACTAC/TTCTTT 5 -- int11Minor allele frequency- T:0.50CSA 2
    rs170465451,2
    C,F,H--55077538(+) AGAAAT/GGAGTC 5 -- int119Minor allele frequency- G:0.09NA NS EA WA 1874
    rs1894842391,2
    --55077571(+) TTAATA/GTAGCC 5 -- int10--------
    rs1473969331,2
    C--55077688(+) ATCTGA/CCAATC 5 -- int10--------
    rs1133902741,2
    F--55077707(+) AAAACG/CCTGAT 5 -- int11Minor allele frequency- C:0.50CSA 2
    rs67343141,2
    C,F,A,H--55077716(+) ATGTTA/CTCTCT 5 -- int133Minor allele frequency- C:0.17NS EA NA WA CSA 2874
    rs1384032131,2
    --55077796(+) AAATAC/TAGACA 5 -- int10--------
    rs46720031,2
    C,F,A,H--55077838(+) TATAAA/GCTGTT 5 -- int131Minor allele frequency- G:0.15NA NS EA WA CSA 2739
    rs1157796631,2
    C,F--55077925(+) TAATAT/CCAAGT 5 -- int11Minor allele frequency- C:0.02WA 118
    rs1438903481,2
    --55077950(+) TACTCA/GCACTG 5 -- int10--------
    rs1143764421,2
    F--55078029(+) GGTTGG/TTATTC 5 -- int11Minor allele frequency- T:0.01WA 118
    rs1844336351,2
    --55078237(+) ACCTCC/TACTAG 5 -- int10--------
    rs118992951,2
    C,F,H--55078276(+) TCCAAC/GAAGCT 5 -- int112Minor allele frequency- G:0.08NS EA NA WA 1316
    rs1890200581,2
    --55078412(+) GAGGAC/TTGCTT 5 -- int10--------
    rs1816507581,2
    --55078429(+) AGGAGA/TTCGAG 5 -- int10--------
    rs65454641,2
    C,F,H--55078571(+) GGAACT/GGTAGA 5 -- int118Minor allele frequency- G:0.18NS EA NA WA CSA 820
    rs1472723731,2
    C--55078576(+) GGTAGA/GAAATT 5 -- int10--------
    rs796246431,2
    C,F--55078719(+) GTCTCG/ATTCTA 5 -- int11Minor allele frequency- A:0.03NA 120
    rs65454651,2
    C,F,H--55078729(+) attgcC/Ttaggc 5 -- int114Minor allele frequency- T:0.15NS EA WA NA CSA 765
    rs1863769471,2
    --55078730(+) TTGCTC/TAGGCT 5 -- int10--------
    rs1154346531,2
    F--55078818(+) GAATAG/ACTGGG 5 -- int11Minor allele frequency- A:0.01WA 118
    rs1896597481,2
    --55078874(+) TAGAGA/CTGGGA 5 -- int10--------
    rs124644471,2
    C,F,A,H--55078887(+) CTCACT/CATGTT 5 -- int17Minor allele frequency- C:0.17WA NA CSA EA 366
    rs784028101,2
    C,F--55078965(+) TTACAG/CGCATG 5 -- int12Minor allele frequency- C:0.15WA 120
    rs1810490171,2
    C--55078979(+) CAACAC/TGTTTG 5 -- int10--------
    rs25885161,2
    C,F,A,H--55078982(-) agccaG/Aacgtg 5 -- int115Minor allele frequency- A:0.13NS EA WA NA CSA 794
    rs1407568361,2
    --55078985(+) GTTTGA/GCTGGC 5 -- int10--------
    rs1144709341,2
    F--55079103(+) AAATAA/GACTTA 5 -- int11Minor allele frequency- G:0.02WA 118
    rs124645951,2
    C,F,A,H--55079317(+) CTGGAT/CCATGT 5 -- int120Minor allele frequency- C:0.35NS EA NA WA CSA 1427
    rs1852656491,2
    --55079702(+) AGTCTA/GTAGAG 5 -- int10--------
    rs802596611,2
    C,F--55079712(+) GGGCCG/AGTGCA 5 -- int11Minor allele frequency- A:0.31WA 118
    rs1911594061,2
    --55079825(+) CAATGC/TAGTAA 5 -- int10--------
    rs1834791311,2
    --55079877(+) GGCCAA/GATAGT 5 -- int10--------
    rs1435606391,2
    --55079977(+) TGGCT-/GGTGTT 5 -- int10--------
    rs1509125341,2
    --55080021(+) TGCATC/TTGGCC 5 -- int10--------
    rs1863306571,2
    --55080210(+) TTTGAC/GGGGAA 5 -- int10--------
    rs1916265911,2
    --55080255(+) TCGGGC/TGTTGG 5 -- int10--------
    rs1393966441,2
    C--55080256(+) CGGGCA/GTTGGT 5 -- int10--------
    rs1138160961,2
    C,F--55080304(+) TTGTGC/TGATGA 5 -- int11Minor allele frequency- T:0.50CSA 2
    rs1180784801,2
    C,F--55080313(+) GAAAAT/CAGTGA 5 -- int11Minor allele frequency- C:0.03EA 120
    rs1834798291,2
    --55080358(+) ATGAGC/TTTTAT 5 -- int10--------
    rs1465945801,2
    --55080363(+) TTTTAC/TGGTAT 5 -- int10--------
    rs1117315211,2
    C,F--55080391(+) TAAAAG/AAGAGG 5 -- int11Minor allele frequency- A:0.50CSA 2
    rs25807681,2
    C,F,A,H--55080407(+) AAACAT/CGCAGA 5 -- int127Minor allele frequency- C:0.15NA NS EA WA CSA 2313
    rs1440692031,2
    --55080457(+) CTCCAC/TAGCAA 5 -- int10--------
    rs1464500981,2
    --55080460(+) CATAGA/CAACTA 5 -- int10--------
    rs1490414061,2
    --55080579(+) AGAAAC/TGAGAA 5 -- int10--------
    rs1881665801,2
    --55080654(+) ACGAAA/CTATCA 5 -- int10--------
    rs1928960421,2
    --55080667(+) AAGCAA/CGTTAT 5 -- int10--------
    rs1430142371,2
    --55080668(+) AGCACA/GTTATC 5 -- int10--------
    rs1482781981,2
    --55080712(+) TCAAAC/TCTACC 5 -- int10--------
    rs1823116051,2
    C--55080762(+) CAATGC/TTTAAC 5 -- int10--------
    rs1865802031,2
    --55080924(+) AAAAAA/TGCATG 5 -- int10--------
    rs1911667471,2
    C--55080984(+) CACTAC/TTGCCA 5 -- int10--------
    rs25807691,2
    C,F,O,A,H--55081010(+) TCCAGC/ACATCT 5 -- int132Minor allele frequency- A:0.33NA NS EA WA CSA EU 4228
    rs1403615491,2
    C--55081011(+) CCAGAC/TATCTC 5 -- int10--------
    rs115498981,2
    C,F--55081031(+) GGTGGC/GCTTCA 10 A G mis13Minor allele frequency- G:0.01NA EU 5877
    rs39160381,2
    H--55081045(-) ATCCAG/AAAATC 10 /Q syn15Minor allele frequency- A:0.00MN NS EA 604
    rs1483223791,2
    C--55081065(+) CACACA/C/TCTTGT 15 S G C mis11NA 4552
    rs2016118991,2
    C--55081113(+) GGCAAT/AGTAGG 10 /I /F mis11Minor allele frequency- A:0.00EU 1323
    rs25807701,2
    C,F,H--55081304(+) AAAAAG/CGCTAC 5 -- int134Minor allele frequency- C:0.19EA NA NS WA CSA 4374
    rs1847595901,2
    --55081330(+) CAAACC/TTAAAA 5 -- int10--------
    rs1904643511,2
    --55081370(+) CTAACC/TTTATA 5 -- int10--------
    rs1381594981,2
    --55081406(+) TTGTAA/TATTAG 5 -- int10--------
    rs1929054931,2
    --55081495(+) ACAATA/GATTAA 5 -- int10--------
    rs1852623751,2
    --55081681(+) CTCTAC/TTGAAA 5 -- int10--------
    rs729108821,2
    C,F--55081860(+) ATCTTG/TGGGTT 5 -- int12Minor allele frequency- T:0.01WA 120
    rs1112308481,2
    F--55081875(+) ATCTCA/CTACAA 5 -- int12Minor allele frequency- C:0.03CSA WA 120
    rs67293431,2
    H--55081944(+) ACACAC/TTAAAA 5 -- int14Minor allele frequency- T:0.00NS EA 418
    rs1436222201,2
    C--55081946(+) ACACTA/GAAATG 5 -- int10--------
    rs1897450011,2
    --55081956(+) GAGATA/GCTTCA 5 -- int10--------
    rs1812269591,2
    C--55081966(+) AGTGAC/TACCAA 5 -- int10--------
    rs67296751,2
    C,F,A,H--55082009(+) AGGCCG/AAGATA 5 -- int15Minor allele frequency- A:0.12NS EA WA 538
    rs1472816701,2
    --55082030(+) ACATAC/TGAATG 5 -- int10--------
    rs1162427271,2
    F--55082043(+) CTTTTT/CTTCTT 5 -- int11Minor allele frequency- C:0.02NA 120
    rs1387844731,2
    --55082157(+) AAGAAA/GAAGAC 5 -- int10--------
    rs1493566001,2