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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RTN4 Gene

protein-coding GIFtS: 66
GCID: GC02M055199

reticulon 4

Explore 33 diseases affiliated with
RTN4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Reticulon 4¹ ²		RTN4-A²
NOGO¹ ² ³ ⁵		RTN4-B1²
ASY¹ ²		RTN4-B2²
NSP-CL¹ ²		RTN4-C²
KIAA0886¹ ³		Foocen³
Neurite Outgrowth Inhibitor² ³		Human NogoA²
Neuroendocrine-Specific Protein C Homolog² ³		My043 Protein²
NSP² ³		Neurite Growth Inhibitor 220²
NI220/250²		Reticulon 5²
NOGO-A²		Reticulon-4¹
NOGOC²		Foocen³
Nbla00271²		RTN-X²
Nbla10545²		Reticulon-5³
Nogo-B²		Neuroendocrine-Specific Protein³
Nogo-C²		Nogo Protein³
RTN-X²

External Ids:	HGNC: 14085¹	Entrez Gene: 57142²	Ensembl: ENSG00000115310⁷	OMIM: 604475⁵	UniProtKB: Q9NQC3³

Export aliases for RTN4 gene to outside databases

Previous GC identifers: GC02M055237 GC02M055386 GC02M055173 GC02M055110 GC02M054934

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RTN4:

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum,

and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this

gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system

in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and

differential promoter usage and encoding different isoforms have been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3

Function: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and

growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the

developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of

plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing

receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely

consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding

and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing

Gene Wiki entry for RTN4 (Reticulon 4)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RTN4 gene promoter:
POU2F1 POU2F1a C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 10): RTN4 promoter sequence

Search SABiosciences Chromatin IP Primers for RTN4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RTN4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.3 Ensembl cytogenetic band: 2p16.1 HGNC cytogenetic band: 2p14-p13

RTN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTN4 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M055199: view genomic region (about GC identifiers)

Start:	55,199,325 bp from pter	End:	55,339,757 bp from pter
Size:	140,433 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3 (See protein sequence)

Recommended Name: Reticulon-4

Size: 1192 amino acids; 129931 Da

Subunit: Binds to RTN4R. Interacts with Bcl-xl and Bcl-2. Isoform 2 binds to NGBR and RTN3. Isoform 2 and isoform 3

interact with BACE1 and BACE2. Interacts with RTN4IP1. Interacts with ATL1

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Anchored to the membrane of the

endoplasmic reticulum through 2 putative transmembrane domains

Sequence caution: Sequence=AAD39920.1; Type=Frameshift; Positions=1149, 1156; Sequence=AAG43160.1; Type=Erroneous

initiation; Note=Translation N-terminally extended; Sequence=AAG43160.1; Type=Frameshift; Positions=684, 700;

Sequence=BAA74909.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

2 PDB 3D structures from and Proteopedia for RTN4:

2G31 (3D)

2JV5 (3D)

Secondary accessions: O94962 Q7L7Q5 Q7L7Q6 Q7L7Q8 Q8IUA4 Q96B16 Q9BXG5 Q9H212 Q9H3I3 Q9UQ42 Q9Y293

Q9Y2Y7 Q9Y5U6

Alternative splicing: 6 isoforms: Q9NQC3-1 Q9NQC3-2 Q9NQC3-3 Q9NQC3-4 Q9NQC3-5 Q9NQC3-6

Explore the universe of human proteins at neXtProt for RTN4: NX_Q9NQC3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NQC3

RTN4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_008939.1 NP_065393.1 NP_722550.1 NP_997403.1 NP_997404.1

ENSEMBL proteins:

ENSP00000378107 ENSP00000384471 ENSP00000349944 ENSP00000337838 ENSP00000322147

ENSP00000350365 ENSP00000378109 ENSP00000385650 ENSP00000397808 ENSP00000411628

ENSP00000384825 ENSP00000346465

Reactome Protein details: Q9NQC3
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for RTN4 (Nogo-A)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): RTN4 OriGene Protein Over-expression Lysate (see all 5): RTN4 OriGene Custom Protein Services for RTN4
	GenScript Custom Purified and Recombinant Proteins Services for RTN4
	Novus Biologicals RTN4 Proteins Novus Biologicals RTN4 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RTN4

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005635	nuclear envelope	IDA	11126360
GO:0005737	cytoplasm	--	--
GO:0005783	endoplasmic reticulum	NAS	11126360
GO:0005886	plasma membrane	TAS	--
GO:0030176	integral to endoplasmic reticulum membrane	IDA	10667797

RTN4 for ontologies About GeneDecksing

RTN4 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of RTN4
	R&D Systems Antibodies for RTN4 (Nogo-A, Nogo-B, Nogo-C)
	OriGene Antibodies (see all 2): RTN4 OriGene Custom Antibody Services for RTN4
	GenScript Custom Superior Antibodies Services for RTN4
	Novus Biologicals RTN4 Antibodies
	Search for Antibodies for RTN4 at Abcam
	Uscn Antibodies for RTN4
	ThermoFisher Antibodies for RTN4

Assay Products for RTN4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RTN4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RTN4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RTN4 for domains About GeneDecksing

1 InterPro domain/family:

IPR003388 Reticulon

Graphical View of Domain Structure for InterPro Entry Q9NQC3

ProtoNet protein and cluster: Q9NQC3

1 Blocks protein family: IPB003388 Reticulon

UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3

Domain: Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane domains,

known as Nogo-66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the spreading of

neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity)

Similarity: Contains 1 reticulon domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3

Function: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and

growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the

developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of

plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing

receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely

consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding

and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing

miRNA Products:		miRTarBase miRNAs that target RTN4: hsa-mir-16 (MIRT001421), hsa-mir-21 (MIRT000167)

		OriGene 3'-UTR Clone (see all 5): RTN4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RTN4
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RTN4 (see all 19):
		hsa-miR-4318 hsa-miR-15a hsa-miR-503 hsa-miR-3692 hsa-miR-424 hsa-miR-195 hsa-miR-497* hsa-miR-15b

		SwitchGear 3'UTR luciferase reporter plasmid: RTN4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RTN4 (see all 7) OriGene shRNA RFP: RTN4 OriGene siRNA: RTN4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RTN4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RTN4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RTN4 (see all 12) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RTN4 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): RTN4 (NM_020532)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RTN4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTN4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RTN4
		Search LifeMap BioReagents cell lines for RTN4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	19665976
GO:0032403	protein complex binding	--	--

RTN4 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for RTN4: Rtn4^tm1Schw Rtn4^tm2.1Matl Rtn4^tm2Matl
     4 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Rtn4):

cellular

mortality/aging

nervous system

normal

RTN4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Axonal growth inhibition (RHOA activation)

Axonal growth inhibition (RHOA activation)

1.00

p75NTR regulates axonogenesis

0.90

Development MAG-dependent inhibition of neurite outgrowth

Development MAG-dependent inhibition of neurite outgrowth

1.00

Development_MAG-dependent inhibition of neurite outgrowth

0.87

NgR-p75(NTR)-Mediated Signaling

NgR-p75(NTR)-Mediated Signaling

1.00

p75(NTR)-mediated signaling

p75(NTR)-mediated signaling

1.00

Cell death signalling via NRAGE, NRIF and NADE

p75 NTR receptor-mediated signalling

0.73

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for RTN4

Development MAG-dependent inhibition of neurite outgrowth

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RTN4

NgR-p75(NTR)-Mediated Signaling

1 GeneGo (Thomson Reuters) Pathway for RTN4

Development MAG-dependent inhibition of neurite outgrowth

1 BioSystems Pathway for RTN4

p75(NTR)-mediated signaling

5 Reactome Pathways for RTN4

	Axonal growth inhibition (RHOA activation)
	Signal Transduction
	p75NTR regulates axonogenesis
	Signalling by NGF
	p75 NTR receptor-mediated signalling

RTN4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RTN4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/65 Interacting proteins for RTN4 (Q9NQC3^{1, 2, 3} ENSP00000337838⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 65)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COL4A3BP	Q9Y5P4²^,³, ENSP00000369862⁴	MINT-68370 I2D: score=5 STRING: ENSP00000369862
FXR2	P51116²^,³, ENSP00000250113⁴	MINT-67869 I2D: score=5 STRING: ENSP00000250113
CRMP1	Q14194²^,³, ENSP00000321606⁴	MINT-65114 I2D: score=4 STRING: ENSP00000321606
ABL1	P00519²^,³, ENSP00000361423⁴	MINT-8110731 I2D: score=3 STRING: ENSP00000361423
FYN	P06241²^,³, ENSP00000357656⁴	MINT-8111499 I2D: score=3 STRING: ENSP00000357656

About this table

Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0006915	apoptotic process	NAS	11126360
GO:0007399	nervous system development	--	--
GO:0007413	axonal fasciculation	ISS	--
GO:0007568	aging	--	--

RTN4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RTN4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RTN4
1 Novoseek chemical compound relationship for RTN4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ddvp	58	1	17029193 (1)

Search CenterWatch for drugs/clinical trials and news about RTN4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RTN4 gene (5 alternative transcripts):

NM_007008.2 NM_020532.4 NM_153828.2 NM_207520.1 NM_207521.1

Unigene Cluster for RTN4:

Reticulon 4

Hs.743996 [show with all ESTs]

Unigene Representative Sequence: NM_020532

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000394609(uc002ryc.3) ENST00000405240 ENST00000357376(uc002ryd.3)

ENST00000337526(uc002rye.3) ENST00000317610(uc002ryg.3) ENST00000357732(uc002ryf.3)

ENST00000394611 ENST00000404909 ENST00000486085 ENST00000491592 ENST00000485749

ENST00000438462 ENST00000427710 ENST00000461004 ENST00000402434 ENST00000354474

miRNA Products:		OriGene 3'-UTR Clone (see all 5): RTN4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RTN4
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RTN4 (see all 19):
		hsa-miR-4318 hsa-miR-15a hsa-miR-503 hsa-miR-3692 hsa-miR-424 hsa-miR-195 hsa-miR-497* hsa-miR-15b

		SwitchGear 3'UTR luciferase reporter plasmid: RTN4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RTN4 (see all 7) OriGene shRNA RFP: RTN4 OriGene siRNA: RTN4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RTN4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RTN4 (see all 12) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RTN4 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): RTN4 (NM_020532)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTN4

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RTN4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTN4

Additional cDNA sequence:

AB015639.1 AB020693.1 AB040462.1 AB040463.1 AB073351.1 AB073359.1 AF063601.1 AF077050.1

AF087901.1 AF125103.1 AF132047.1 AF132048.1 AF148537.1 AF148538.1 AF177332.1 AF320999.1

AF333336.1 AJ251383.1 AJ251384.1 AJ251385.1 AK075039.1 AK098385.1 AK129806.1 AK130812.1

AK172726.1 AK302741.1 AY102276.1 AY102277.1 AY102278.1 AY102279.1 AY123245.1 AY123246.1

AY123247.1 AY123248.1 AY123249.1 AY123250.1 BC001035.2 BC007109.1 BC010737.1 BC012619.1

BC014366.1 BC016165.1 BC026788.1 BC068991.1 BC071848.1 BC150182.1 BC152425.1 BC152555.1

DQ778739.1

24/70 DOTS entries (see all 70):

DT.87018236 DT.92057768 DT.91855184 DT.97862663 DT.100039375 DT.95148397 DT.100889622 DT.100039374

DT.97776594 DT.100889645 DT.100039372 DT.121021010 DT.100889631 DT.420660 DT.100889638 DT.100889649

DT.100889641 DT.100889621 DT.121021012 DT.408266 DT.95329023 DT.95128616 DT.100889636 DT.102838873

24/1507 AceView cDNA sequences (see all 1507):

W19399 BM470283 CA421240 AU104979 AA081525 BG570231 AW169711 BM983902

T32248 AB040462 AA329816 AA911774 AI699241 AI348346 AY123250 BM709730

AI066675 AW264441 BM677436 W21129 CB108617 AW305370 AA576133 BU729639

GeneLoc Exon Structure

5/18 Alternative Splicing Database (ASD) splice patterns (SP) for RTN4 (see all 18) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15a	·	15b	·	15c	·	15d	^	16	^
SP1:			-		-		-		-		-		-		-		-		-		-						-		-		-								-				-		-
SP2:									-		-		-		-		-		-		-						-		-		-								-				-		-
SP3:													-		-		-		-		-						-		-		-								-				-		-
SP4:																	-		-		-						-		-		-								-				-		-
SP5:																			-		-						-		-		-								-				-		-

ExUns:	17a	·	17b	·	17c	·	17d
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for RTN4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RTN4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATGCCACA

About this image

RTN4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Retina

Eye

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RTN4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RTN4

SOURCE GeneReport for Unigene cluster: Hs.743996

UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3

Tissue specificity: Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle.

Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes.

Isoform 4 is testis-specific

SABiosciences Expression via Pathway-Focused PCR Arrays including RTN4:

Neurogenesis in human mouse rat

Nephrotoxicity in human mouse rat

Apoptosis 384HT in human mouse rat

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RTN4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RTN4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTN4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RTN4 gene from 5/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RTN4¹	reticulon 4	65.24(n) 54.37(a)		378790 XM_003640893.1 XP_003640941.1
lizard (Anolis carolinensis)	Reptilia	RTN4⁶	--	45(a)	1 ↔ 1	1(263837302-263900362)
African clawed frog (Xenopus laevis)	Amphibia	MGC68489²	hypothetical protein MGC68489	78.12(n)		BC059960.1
zebrafish (Danio rerio)	Actinopterygii	Dr.24718²	Transcribed sequence with weak similarity to protein more	74.33(n)		57038777
fruit fly (Drosophila melanogaster)	Insecta	Rtnl2⁶ Rtnl1⁶ (see all 3)	Rtnl1 (see all 3)	24(a) 23(a) (see all 3)	possible ortholog 1 ↔ many (see all 3)	3R(3354586-3355963) 2L(4992808-5009720)

ENSEMBL Gene Tree for RTN4 (if available)
TreeFam Gene Tree for RTN4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RTN4 gene

RTN3² RTN1² RTN2²

6 SIMAP similar genes for RTN4 using alignment to 10 protein entries: RTN4_HUMAN (see all proteins):

NOGOC Nbla10545 Nbla00271 RTN3 RTN1 RTN2

RTN4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150500955^1,2		--	55198856(+)	`CATGTC/TTGCCT`	6	--	ut3¹ ds500¹		0	--	--	--	--
rs77408068^1,2	F,	--	55198935(+)	`CGATTA/GATGAT`	6	--	ds500¹ ut3¹		1		WA	118
rs78708827^1,2		--	55199052(+)	`CTGCAC/GTGTAT`	6	--	ut3¹ ds500¹		1		NA	120
rs887^1,2	C,F,O,A,H,	--	55199068(-)	`TTAACT/CCACAT`	6	--	ds500¹ ut3¹		35		MN EA NA NS WA CSA	5199
rs80098385^1,2	F,	--	55199090(+)	`ATGAAT/ATTATT`	6	--	ut3¹ ds500¹		1		WA	118
rs191098487^1,2		--	55199112(+)	`AAACAC/TATCAC`	6	--	ut3¹ ds500¹		0	--	--	--	--
rs3839054^1,2	C	--	55199171(-)	`AACAA-/AAGTCAA`	6	--	ds500¹		0	--	--	--	--
rs58923960^1,2	C,	--	55199171(+)	`TTGAC-/TTTTGTT`	6	--	ds500¹		0	--	--	--	--
rs183285861^1,2		--	55199184(+)	`CCACAA/GTAAAC`	6	--	ds500¹		0	--	--	--	--
rs138875610^1,2		--	55199186(+)	`ACAGT-/AAAC AAACA`	6	--	ds500¹		0	--	--	--	--
rs139628572^1,2		--	55199223(+)	`AAAACA/CCTTCT`	6	--	ds500¹		0	--	--	--	--
rs201429720^1,2		--	55199227(+)	`CCTTC-/TATAAAA`	6	--	ds500¹		0	--	--	--	--
rs2588510^1,2	C,F,O,A,H,	--	55199248(-)	`CCAGCG/AAATGG`	6	--	ds500¹		28		EA NA NS WA	4216
rs143437258^1,2		--	55199304(+)	`TCATGA/GAATGA`	6	--	ds500¹		0	--	--	--	--
rs112105650^1,2	C	--	55199351(+)	`TGATAT/CTTTGC`	6	--	ut3¹ ds500¹		1		CSA	1
rs15029^1,2	C,F,H,	--	55199442(+)	`AATAAT/ATTCTT`	6	--	ds500¹ ut3¹		12		MN NS EA NA WA	1750
rs142955736^1,2		--	55199469(+)	`ATTTG-/CAAA CAAAC`	6	--	ds500¹ ut3¹		0	--	--	--	--
rs112785682^1,2	C,	--	55199499(+)	`ATTAGA/GTTCAG`	6	--	ut3¹ ds500¹		2		CSA WA	120
rs15028^1,2	C,F,O,H,	--	55199510(+)	`TCCATA/CGATTC`	6	--	ut3¹ ds500¹ ese³		20		MN NA NS EA WA	2064
rs5831331^1,2	C,	--	55199557(+)	`ATTGA-/TGTTGTTG`	6	--	ut3¹ ds500¹		0	--	--	--	--
rs77225605^1,2	C,	--	55199557(+)	`AATTGT/ATGTTG`	6	--	ut3¹ ds500¹		1		CSA	2
rs34917480^1,2	C	--	55199562(+)	`TGTTGTTG/-GAGTT`	6	--	ds500¹ ut3¹		1		NA	2
rs187115076^1,2		--	55199571(+)	`TTCTAC/TGTGTG`	6	--	ut3¹ ds500¹		0	--	--	--	--
rs7573286^1,2	C	--	55199764(+)	`TTATAC/TTGGCA`	5	--	ut3¹		0	--	--	--	--
rs192029683^1,2		--	55199793(+)	`GTCACA/TATACA`	5	--	ut3¹		0	--	--	--	--
rs17046520^1,2	C,F,H,	--	55199848(+)	`CGGTAT/CGATCT`	5	--	ut3¹ ese³		14		NA NS EA WA	1628
rs146272136^1,2	C,	--	55199899(+)	`CTACAC/TGGACC`	5	--	ut3¹		0	--	--	--	--
rs139348498^1,2	C,	--	55199921(+)	`ACAAAC/TTGAAA`	5	--	ut3¹		0	--	--	--	--
rs199976185^1,2	C	--	55199948(+)	`TTTTTC/TTAGCT`	5	--	ut3¹		0	--	--	--	--
rs67682513^1,2	C,F,	--	55200039(+)	`GCCTCAGAT/- AGATA`	5	--	ut3¹		2		NA CSA	4
rs10610251^1,2	C	--	55200041(+)	`GATAG-/ATAG GAAAA`	5	--	ut3¹		1		NA	2
rs199722940^1,2	C	--	55200042(+)	`TCAGAC/TAGATA`	5	--	ut3¹		0	--	--	--	--
rs144089719^1,2	C,	--	55200065(+)	`GATTAA/C/TGGTTT`	10	--	ut3¹		0	--	--	--	--
rs7588687^1,2	C,H,	--	55200081(+)	`CATACA/GTAGCA`	5	--	ut3¹ ese³		4		NS EA	418
rs11549897^1,2	H	--	55200087(+)	`TAGCAG/ACTTAC`	5	--	ut3¹ ese³		4		NS EA	420
rs188462887^1,2	C,	--	55200104(+)	`TAAGAA/TGATGA`	5	--	ut3¹		0	--	--	--	--
rs192549959^1,2	C,	--	55200178(+)	`AACAAC/TGATCT`	5	--	ut3¹		0	--	--	--	--
rs1801911^1,2	C	--	55200212(-)	`AAGAAC/TGAACC`	5	--	ut3¹		0	--	--	--	--
rs182249122^1,2	C,	--	55200233(+)	`CCCCCA/GTATAA`	5	--	ut3¹		0	--	--	--	--
rs145269375^1,2	C,	--	55200295(+)	`TTTCAC/TTCAGC`	10	E	syn¹		0	--	--	--	--
rs200000051^1,2		--	55200306(+)	`TTTGCA/GCTTCA`	10	R C	mis¹		0	--	--	--	--
rs186556285^1,2	C,	--	55200347(+)	`TGAAAA/TAGTCA`	5	--	int¹		0	--	--	--	--
rs149157025^1,2		--	55200391(+)	`AATACC/TATCTT`	5	--	int¹		0	--	--	--	--
rs3739104^1,2	H	--	55200430(-)	`TTTATT/CGTATT`	5	--	int¹		4		NS EA	420
rs191189148^1,2		--	55200537(+)	`GAAACA/GAATGG`	5	--	int¹		0	--	--	--	--
rs139725667^1,2		--	55200556(+)	`TAGAA-/AAAC AAACA`	5	--	int¹		0	--	--	--	--
rs184818504^1,2	C,	--	55200784(+)	`ATTATG/TACCGT`	5	--	int¹		0	--	--	--	--
rs2255112^1,2	C,F,O,H,	--	55200800(-)	`ATAAGA/CTTCTT`	5	--	int¹		24		EA NA NS WA	3964
rs190345834^1,2		--	55200895(+)	`CATCCA/GTAAAT`	5	--	int¹		0	--	--	--	--
rs193200963^1,2	C,	--	55200926(+)	`CTCTAC/TTCTGA`	5	--	int¹		0	--	--	--	--
rs112251136^1,2	C	--	55200955(+)	`AAATTA/G/TCCTGA`	5	--	spd¹		1		CSA	1
rs2255026^1,2	C,F,A,H,	--	55201038(-)	`ATTCCA/GTTCTT`	5	--	int¹		19		EA NS NA WA CSA EU	3458
rs112157194^1,2	F	--	55201066(+)	`TCAAAAAA/-CTATT`	5	--	int¹		1		CSA	4
rs184986339^1,2		--	55201091(+)	`ACTCAA/GGATAA`	5	--	int¹		0	--	--	--	--
rs11892015^1,2	C,F,H,	--	55201361(+)	`ACTAAG/CGTAGC`	5	--	int¹		7		NS EA WA NA	542
rs189884733^1,2		--	55201410(+)	`AAAGAA/GAATAC`	5	--	int¹		0	--	--	--	--
rs142280476^1,2		--	55201421(+)	`AACCTC/TAAACT`	5	--	int¹		0	--	--	--	--
rs181144122^1,2		--	55201476(+)	`AATGGC/GACGAT`	5	--	int¹		0	--	--	--	--
rs185405110^1,2		--	55201580(+)	`CCAGCC/TAATTT`	5	--	int¹		0	--	--	--	--
rs151237291^1,2		--	55201728(+)	`TTCATC/TCCCTA`	5	--	int¹		0	--	--	--	--
rs201634113^1,2		--	55201928(+)	`CATTAA/TAAACA`	5	--	int¹		0	--	--	--	--
rs188401405^1,2	C,	--	55201948(+)	`TAAAGC/TTTCTT`	5	--	int¹		0	--	--	--	--
rs141859204^1,2		--	55201951(+)	`AGTTTC/TTTAAT`	5	--	int¹		0	--	--	--	--
rs118130237^1,2		--	55201999(+)	`CAAAAG/TGCATA`	5	--	int¹		1		EA	120
rs180819239^1,2		--	55202010(+)	`CAACTG/TGAAGA`	5	--	int¹		0	--	--	--	--
rs187654178^1,2		--	55202125(+)	`CACTAC/TCAAGT`	5	--	int¹		0	--	--	--	--
rs191965309^1,2		--	55202254(+)	`ATTGAC/TTTCAA`	5	--	int¹		0	--	--	--	--
rs112154604^1,2		--	55202265(+)	`AGTATG/AAACTA`	5	--	int¹		2		CSA WA	120
rs183704047^1,2		--	55202432(+)	`GAATTC/TTGTTA`	5	--	int¹		0	--	--	--	--
rs7570298^1,2	C,F,A,H,	--	55202455(+)	`CATCAG/ATTCCT`	5	--	int¹		11		NS EA NA WA CSA	800
rs147125535^1,2		--	55202505(+)	`ATCACC/TTTGAC`	5	--	int¹		0	--	--	--	--
rs138533224^1,2		--	55202639(+)	`TTCTCC/TGTGAA`	5	--	int¹		0	--	--	--	--
rs2588522^1,2	C,F,H,	--	55202649(-)	`TGTCTA/GGCTCT`	5	--	int¹		20		NS EA NA WA CSA	1207
rs72795421^1,2	C,F,	--	55202760(+)	`CCCACA/GCTATA`	5	--	int¹		1		NA	120
rs114449013^1,2	F,	--	55202803(+)	`TTTGCT/CAACCC`	5	--	int¹		1		WA	118
rs142571157^1,2		--	55202823(+)	`AGCATA/CTATCT`	5	--	int¹		0	--	--	--	--
rs74938921^1,2	F,	--	55202845(+)	`TTAAAC/TGAACT`	5	--	int¹		1		WA	118
rs150238546^1,2		--	55202877(+)	`ATTAAA/TTAAGC`	5	--	int¹		0	--	--	--	--
rs72795422^1,2	C,	--	55202895(+)	`CATTAC/GTAAGC`	5	--	int¹		0	--	--	--	--
rs186590467^1,2		--	55202909(+)	`TTTATC/TACAGC`	5	--	int¹		0	--	--	--	--
rs190181518^1,2		--	55202928(+)	`ACACTG/TTGGAT`	5	--	int¹		0	--	--	--	--
rs149474081^1,2		--	55202940(+)	`ACTCTA/TCCAAG`	5	--	int¹		0	--	--	--	--
rs182624679^1,2		--	55202949(+)	`AGCAAC/TAGTTC`	5	--	int¹		0	--	--	--	--
rs186942997^1,2		--	55202985(+)	`CTAACG/TGAATT`	5	--	int¹		0	--	--	--	--
rs143875805^1,2		--	55203040(+)	`GTCAAA/TTGAAA`	5	--	int¹		0	--	--	--	--
rs191437989^1,2		--	55203154(+)	`TTATAA/GACTCC`	5	--	int¹		0	--	--	--	--
rs72910870^1,2	C,F,	--	55203207(+)	`ACTATA/GGAGTA`	5	--	int¹		4		WA CSA	124
rs182557996^1,2		--	55203315(+)	`TTAACA/GTGACA`	5	--	int¹		0	--	--	--	--
rs148206335^1,2		--	55203326(+)	`GAAGAC/TAGTAA`	5	--	int¹		0	--	--	--	--
rs3754767^1,2	C,F,H,	--	55203328(-)	`TGTTAC/GTATCT`	5	--	int¹		6		EA NS	2044
rs113902898^1,2	C,	--	55203452(+)	`AATGTC/TACTTG`	5	--	int¹		2		CSA WA	120
rs189068019^1,2		--	55203473(+)	`AACACC/TTCCTA`	5	--	int¹		0	--	--	--	--
rs78327294^1,2		--	55203648(+)	`GCTGTA/GGCCAT`	5	--	int¹		0	--	--	--	--
rs193020964^1,2		--	55203734(+)	`ATGTTC/GAGAAA`	5	--	int¹		0	--	--	--	--
rs77065339^1,2	F,	--	55203740(+)	`AGAAAA/CCTGAA`	5	--	int¹		1		WA	118
rs2588521^1,2	C,F,O,A,H,	--	55203931(-)	`GAGCAG/CCCTGT`	5	--	int¹		14		NA NS EA CSA WA	928
rs146283803^1,2		--	55203935(+)	`GCTGCC/TCTCAT`	5	--	int¹		0	--	--	--	--
rs2580765^1,2	C,F,O,A,H,	--	55204028(+)	`AGCTTA/CTCTCT`	5	--	int¹		24		EA NA NS CSA WA	3944
rs80159482^1,2		--	55204043(+)	`TGCACA/GGTATC`	5	--	int¹		2		CSA WA	120
rs4672002^1,2	H	--	55204125(+)	`CATCTG/AGTTTA`	5	--	int¹		4		NS EA	420
rs142584781^1,2		--	55204131(+)	`GTTTAC/TCTTTC`	5	--	int¹		0	--	--	--	--
rs150552929^1,2		--	55204153(+)	`TAAGAA/GAATTA`	5	--	int¹		0	--	--	--	--
rs6705519^1,2	C,F,A,	--	55204165(+)	`ATTCAC/TTGTGT`	5	--	int¹		4		WA CSA NA	242
rs114309253^1,2	C,F,	--	55204219(+)	`AATTTG/AGGGGA`	5	--	int¹		1		WA	118
rs185349633^1,2		--	55204232(+)	`GGGTAC/TCTTTA`	5	--	int¹		0	--	--	--	--
rs141618190^1,2	C,	--	55204264(+)	`TTAGT-/AAGATC`	5	--	int¹		0	--	--	--	--
rs189882190^1,2		--	55204293(+)	`GTTCTC/GACCAT`	5	--	int¹		0	--	--	--	--
rs139784963^1,2		--	55204351(+)	`TGTGTC/GTCCTT`	5	--	int¹		0	--	--	--	--
rs149785925^1,2		--	55204399(+)	`ATATCC/TCCAGC`	5	--	int¹		0	--	--	--	--
rs192076584^1,2		--	55204406(+)	`CAGCCC/TACTTC`	5	--	int¹		0	--	--	--	--
rs184301013^1,2		--	55204410(+)	`CCACTG/TCCTTC`	5	--	int¹		0	--	--	--	--
rs2968804^1,2	C,F,O,A,H,	--	55204498(-)	`AAAATG/CTAGCT`	5	--	int¹		22		NA NS EA WA CSA	1354
rs188648803^1,2		--	55204510(+)	`GTGTTA/CTTCTG`	5	--	int¹		0	--	--	--	--
rs11899197^1,2	C,F,H,	--	55204537(+)	`AGCTCA/GGGCCG`	5	--	int¹		1		WA	118
rs71410404^1,2	C,F	--	55204542(+)	`GGCCGT/-TTTTT`	5	--	int¹		2		NA CSA	4
rs200389294^1,2	C	--	55204556(-)	`AGGAAA/GAAAAA`	5	--	int¹		0	--	--	--	--
rs181076011^1,2		--	55204590(+)	`GTTCTC/GGAACA`	5	--	int¹		0	--	--	--	--
rs3769327^1,2	C,F,H,	--	55204605(-)	`GAGGCG/ACAACT`	5	--	int¹		5		NS EA	540
rs185779235^1,2		--	55204658(+)	`TAGTCC/TCTAAA`	5	--	int¹		0	--	--	--	--
rs190686822^1,2		--	55204729(+)	`AGAAGC/GCTCAG`	5	--	int¹		0	--	--	--	--
rs72795424^1,2	C,	--	55204738(+)	`AGTCAC/GACTCA`	5	--	int¹		0	--	--	--	--
rs117010173^1,2	F,	--	55204744(+)	`ACTCAA/GTTAGC`	5	--	int¹		1		EA	120
rs2580766^1,2	C,F,H,	--	55204800(+)	`AATTGG/CGGGTG`	5	--	int¹		16		NS EA NA WA CSA	786
rs181980113^1,2		--	55204802(+)	`TTGCGA/GGTGGG`	5	--	int¹		0	--	--	--	--
rs139911535^1,2		--	55204865(+)	`GATTTC/TTGCCA`	5	--	int¹		0	--	--	--	--
rs3769326^1,2	C,F,H,	--	55204895(-)	`AGCAAC/AGATCA`	5	--	int¹		5		NS EA	540
rs145340816^1,2		--	55204973(+)	`CAAACA/GGAATA`	5	--	int¹		0	--	--	--	--
rs10188602^1,2	H	--	55204992(+)	`GAATTT/AAAAAG`	5	--	int¹		4		NS EA	420
rs147752116^1,2		--	55205031(+)	`TATTCA/GCCCAA`	5	--	int¹		0	--	--	--	--
rs187274654^1,2		--	55205089(+)	`CACACC/TGGTGT`	5	--	int¹		0	--	--	--	--
rs2588520^1,2	C,F,H,	--	55205092(-)	`TAAACG/ACCGGT`	5	--	int¹		21		EA NS NA WA CSA	2430
rs2588519^1,2	C,F,A,H,	--	55205124(-)	`TAACCG/AAACTC`	5	--	int¹		26		EA NS NA WA CSA	3962
rs115114228^1,2	C,F,	--	55205190(+)	`GGCAAT/GAAGCA`	5	--	int¹		1		WA	118
rs116721414^1,2	F,	--	55205247(+)	`TTCTGA/CGGAAG`	5	--	int¹		1		WA	118
rs190628183^1,2		--	55205257(+)	`GATGGC/TTTCAC`	5	--	int¹		0	--	--	--	--
rs2919125^1,2	C,F,O,H,	--	55205262(+)	`TTTCAA/CATGGA`	5	--	int¹		26		NS EA NA WA CSA	1880
rs142605778^1,2		--	55205323(+)	`CACTCC/TGGGAG`	5	--	int¹		0	--	--	--	--
rs181511745^1,2		--	55205378(+)	`CTGGCC/TAACTT`	5	--	int¹		0	--	--	--	--
rs185654669^1,2		--	55205503(+)	`AAAGGC/TTGCAG`	5	--	int¹		0	--	--	--	--
rs189922011^1,2		--	55205516(+)	`AGCCTA/CAGATC`	5	--	int¹		0	--	--	--	--
rs112093980^1,2	C,	--	55205522(+)	`AGATCA/GCACCA`	5	--	int¹		0	--	--	--	--
rs182888296^1,2		--	55205526(+)	`CGCACC/TACCGC`	5	--	int¹		0	--	--	--	--
rs187487550^1,2		--	55205529(+)	`ACCACC/TGCCCT`	5	--	int¹		0	--	--	--	--
rs151288793^1,2		--	55205541(+)	`CAGCCC/TGGGTG`	5	--	int¹		0	--	--	--	--
rs192387278^1,2		--	55205554(+)	`ACAGCG/TAGACT`	5	--	int¹		0	--	--	--	--
rs34302889^1,2	C	--	55205568(+)	`CTCCAA/-AAAAA`	5	--	int¹		1		NA	2
rs202000601^1,2		--	55205584(+)	`AAAAA-/GAAAAA`	5	--	int¹		0	--	--	--	--
rs140550689^1,2		--	55205629(+)	`TGTAGA/CTATAA`	5	--	int¹		0	--	--	--	--
rs150124871^1,2		--	55205779(+)	`GAAATC/GAGAGT`	5	--	int¹		0	--	--	--	--
rs184012678^1,2		--	55205845(+)	`TCATAC/TAAAAT`	5	--	int¹		0	--	--	--	--
rs187839930^1,2		--	55205863(+)	`ATTCCA/GATAAA`	5	--	int¹		0	--	--	--	--
rs192323160^1,2		--	55205890(+)	`ATTTTA/TAAAAA`	5	--	int¹		0	--	--	--	--
rs6739210^1,2	C,F,H,	--	55205947(+)	`ACTGGG/AGCTAT`	5	--	int¹		19		NA NS EA WA CSA	938
rs73936512^1,2	C,	--	55206005(+)	`AAATCC/TGTTTA`	5	--	int¹		2		WA	120
rs76885098^1,2	C,	--	55206059(+)	`AGAATG/AGGAAT`	5	--	int¹		3		WA NA	240
rs138578508^1,2		--	55206114(+)	`TTCCCC/TACCAG`	5	--	int¹		0	--	--	--	--
rs141562816^1,2		--	55206147(+)	`AGTAAA/TACAGT`	5	--	int¹		0	--	--	--	--
rs145210820^1,2		--	55206178(+)	`ATTAAC/GATTTT`	5	--	int¹		0	--	--	--	--
rs184532451^1,2		--	55206214(+)	`AGACAA/GGGTCT`	5	--	int¹		0	--	--	--	--
rs187194422^1,2		--	55206249(+)	`CAGTGG/TTATGA`	5	--	int¹		0	--	--	--	--
rs191654076^1,2		--	55206329(+)	`GACTAA/CAGGCA`	5	--	int¹		0	--	--	--	--
rs117646047^1,2	F,	--	55206344(+)	`CGACCA/TTGGCT`	5	--	int¹		1		EA	120
rs5831332^1,2	C	--	55206364(+)	`TTCAGT/-TTTTT`	5	--	int¹ trp³		2		NA	4
rs184549546^1,2		--	55206394(+)	`TCACAA/GTGTTG`	5	--	int¹		0	--	--	--	--
rs1055980^1,2	H	--	55206569(-)	`GAGACT/CTCTGT`	5	--	int¹		6		MN NS EA NA	606
rs113833384^1,2		--	55206599(+)	`CAAGCG/ATTTTT`	5	--	int¹		1		CSA	2
rs116539669^1,2	F,	--	55206615(+)	`AAAGCA/TAAGTG`	5	--	int¹		1		WA	118
rs116847892^1,2	F,	--	55206683(+)	`CTGTAT/CATTCA`	5	--	int¹		1		EA	120
rs117963313^1,2		--	55206778(+)	`ACAAGG/ATTTAT`	5	--	int¹		1		EA	120
rs189276106^1,2		--	55206785(+)	`TTATCA/GTTTAT`	5	--	int¹		0	--	--	--	--
rs149525730^1,2		--	55206938(+)	`GTGCTA/TACATG`	5	--	int¹		0	--	--	--	--
rs180825535^1,2		--	55206961(+)	`TTACTC/TATTTG`	5	--	int¹		0	--	--	--	--
rs73936513^1,2	C,	--	55207063(+)	`AAGTAC/TGTTTT`	5	--	int¹		4		WA CSA NA	241
rs144042260^1,2		--	55207153(+)	`TAAGAA/TACAAC`	5	--	int¹		0	--	--	--	--
rs185710552^1,2		--	55207173(+)	`AGAAAA/GGAAAT`	5	--	int¹		0	--	--	--	--
rs189307952^1,2		--	55207326(+)	`AGAAAC/TTAAAA`	5	--	int¹		0	--	--	--	--
rs181561802^1,2		--	55207461(+)	`AACATG/TTTCTC`	5	--	int¹		0	--	--	--	--
rs185706516^1,2		--	55207678(+)	`TAGACA/GTATAG`	5	--	int¹		0	--	--	--	--
rs3198123^1,2	C,F,O,H,	--	55207693(-)	`TAGCAG/ATGAAG`	5	--	int¹		20		NA NS EA WA CSA	2348
rs148675943^1,2		--	55207756(+)	`TTGAAC/TCTATA`	5	--	int¹		0	--	--	--	--
rs190167149^1,2		--	55207846(+)	`ACTACC/TAAATT`	5	--	int¹		0	--	--	--	--
rs181179923^1,2		--	55207873(+)	`CTGTTG/TGAAGC`	5	--	int¹		0	--	--	--	--
rs2919126^1,2	C,F,A,H,	--	55207895(+)	`ACTTAT/CAGACA`	5	--	int¹		15		NS EA NA WA CSA	758
rs111580248^1,2		--	55207916(+)	`TCAGTC/AAATTC`	5	--	int¹		1		CSA	2
rs186428636^1,2		--	55207989(+)	`TGTTCC/TACCCT`	5	--	int¹		0	--	--	--	--
rs190921984^1,2		--	55208035(+)	`AATAGG/TAACTG`	5	--	int¹		0	--	--	--	--
rs3769323^1,2	C,F,H,	--	55208070(-)	`GAAATA/GGAACC`	5	--	int¹		6		EA NS	2044
rs150859849^1,2		--	55208128(+)	`CAAGCA/GTGCCA`	5	--	int¹		0	--	--	--	--
rs139951943^1,2		--	55208162(+)	`ATTTAA/CAGACT`	5	--	int¹		0	--	--	--	--
rs182817750^1,2		--	55208228(+)	`CTATAC/TGAAAG`	5	--	int¹		0	--	--	--	--
rs188086756^1,2		--	55208356(+)	`AAGCCC/TAGAGA`	5	--	int¹		0	--	--	--	--
rs190857731^1,2	C,	--	55208402(+)	`TTATAA/CAGGCT`	5	--	int¹		0	--	--	--	--
rs145702336^1,2	C,	--	55208412(+)	`AAATG-/TTTTTT`	5	--	int¹		0	--	--	--	--
rs2580767^1,2	C,F,A,H,	--	55208419(+)	`TTTTTT/GTTTTT`	5	--	int¹		5		NA WA	10
rs183077551^1,2		--	55208474(+)	`TTCAGA/TAATTG`	5	--	int¹		0	--	--	--	--
rs116630214^1,2	F,	--	55208800(+)	`GCAAGG/CTGAGA`	5	--	int¹		1		WA	118
rs62134818^1,2	C,	--	55208844(+)	`AACTAA/CAGAAA`	5	--	int¹		2		NA	122
rs2588513^1,2	C,F,O,H,	--	55208868(+)	`TACCAA/GTTGAA`	5	--	int¹		18		NA NS EA WA CSA	928
rs61621549^1,2	C,	--	55208869(+)	`ACCAGT/CTGAAG`	5	--	int¹		3		WA NA	240
rs147657512^1,2		--	55208899(+)	`AATATG/TAAATC`	5	--	int¹		0	--	--	--	--
rs141028249^1,2		--	55208908(+)	`TCTTAC/TCTAGA`	5	--	int¹		0	--	--	--	--
rs144421626^1,2	C,	--	55208953(+)	`GTACA-/TATGAATCACAT ACAAGCTAAGAAACTAAGT`	5	--	int¹		0	--	--	--	--
rs201411028^1,2		--	55209037(+)	`ATTCC-/GATT AATTT`	5	--	int¹		0	--	--	--	--
rs199818227^1,2		--	55209038(+)	`TTCCG-/ATTA ATTTC`	5	--	int¹		0	--	--	--	--
rs146560550^1,2	C,	--	55209081(+)	`ATTAC-/TATATAT`	5	--	int¹		0	--	--	--	--
rs149865106^1,2		--	55209140(+)	`GGCTGC/GAATGC`	5	--	int¹		0	--	--	--	--
rs2588514^1,2	C,A,H,	--	55209177(+)	`CCTCTA/GCCTCC`	5	--	int¹		2		NA	4
rs7576504^1,2	C,	--	55209226(+)	`tagctG/Aggatt`	5	--	int¹		1		CSA	2
rs143753052^1,2		--	55209235(+)	`TTACAA/GGCATG`	5	--	int¹		0	--	--	--	--
rs71795397^1,2	C,	--	55209280(+)	`AGAGA-/CGG GGTTTCTCCA`	5	--	int¹		0	--	--	--	--
rs75479139^1,2	C	--	55209405(+)	`TGATTC/TATAAC`	5	--	int¹		0	--	--	--	--
rs187410536^1,2		--	55209440(+)	`AGGACG/TCTCTG`	5	--	int¹		0	--	--	--	--
rs193061187^1,2		--	55209571(+)	`GAATAC/TAGAAG`	5	--	int¹		0	--	--	--	--
rs142622923^1,2	C,	--	55209706(+)	`TTATCG/ATGCAG`	10	/T /M	mis¹		1		NA	4548
rs140801868^1,2	C	--	55209708(+)	`ATCGTG/ACAGTT`	10	/C	syn¹		1		NA	4548
rs147780849^1,2	C,F,	--	55209766(+)	`ATATAC/G/TCAACT`	15	D A G	mis¹		1		NA	4550
rs188220648^1,2	C,	--	55209823(+)	`ACTAAC/TTGGAG`	5	--	int¹		0	--	--	--	--
rs75916574^1,2		--	55209986(+)	`ACAGAA/GAAAGC`	5	--	int¹		1		WA	118
rs112997891^1,2		--	55210024(+)	`GCTTGT/AATCTG`	5	--	int¹		1		CSA	2
rs10192771^1,2	H	--	55210035(+)	`atgctC/Ttgcca`	5	--	int¹		4		NS EA	420
rs140269304^1,2		--	55210106(+)	`ATTTAC/TAAAGT`	5	--	int¹		0	--	--	--	--
rs192506221^1,2		--	55210160(+)	`CTGAGC/TACAAG`	5	--	int¹		0	--	--	--	--
rs200104634^1,2	C	--	55210215(-)	`TTTAAA/GAAAAA`	5	--	int¹		0	--	--	--	--
rs111701272^1,2		--	55210271(+)	`TTCATC/TTCCAA`	5	--	int¹		1		CSA	2
rs137857606^1,2		--	55210310(+)	`GGGGAA/CATTGT`	5	--	int¹		0	--	--	--	--
rs141627116^1,2		--	55210320(+)	`TTCAAC/TATGTC`	5	--	int¹		0	--	--	--	--
rs72910876^1,2	C,	--	55210416(+)	`CATACC/TGAGAT`	5	--	int¹		0	--	--	--	--
rs142672156^1,2	C,	--	55210458(+)	`TTGGT-/AATA AATAA`	5	--	int¹		0	--	--	--	--
rs67259950^1,2	C,	--	55210488(+)	`ATAAAT/AAAAAA`	5	--	int¹		3		NA EA	242
rs17418675^1,2	C,F,H,	--	55210605(+)	`CTGAGT/CGTTCC`	5	--	int¹		22		NA NS EA WA CSA	2484
rs79110229^1,2	C	--	55210785(+)	`CACTTA/TCTATT`	5	--	int¹		0	--	--	--	--
rs57397060^1,2		--	55210794(+)	`TTTACG/AAGCTG`	5	--	int¹		1		CSA	2
rs2588515^1,2	C,F,O,A,H,	--	55210856(+)	`CATTCT/CGTCAG`	5	--	int¹		32		NA NS EA WA CSA	2816
rs183614176^1,2		--	55210940(+)	`GACCTA/GCCACT`	5	--	int¹		0	--	--	--	--
rs112792087^1,2		--	55211124(+)	`AACTAC/TTCTTT`	5	--	int¹		1		CSA	2
rs17046545^1,2	C,F,H,	--	55211146(+)	`AGAAAT/GGAGTC`	5	--	int¹		19		NA NS EA WA	1874
rs189484239^1,2		--	55211179(+)	`TTAATA/GTAGCC`	5	--	int¹		0	--	--	--	--
rs147396933^1,2		--	55211296(+)	`ATCTGA/CCAATC`	5	--	int¹		0	--	--	--	--
rs113390274^1,2		--	55211315(+)	`AAAACG/CCTGAT`	5	--	int¹		1		CSA	2
rs6734314^1,2	C,F,A,H,	--	55211324(+)	`ATGTTA/CTCTCT`	5	--	int¹		33		NS EA NA WA CSA	2874
rs138403213^1,2		--	55211404(+)	`AAATAC/TAGACA`	5	--	int¹		0	--	--	--	--
rs4672003^1,2	C,F,A,H,	--	55211446(+)	`TATAAA/GCTGTT`	5	--	int¹		31		NA NS EA WA CSA	2739
rs115779663^1,2	C,F,	--	55211533(+)	`TAATAT/CCAAGT`	5	--	int¹		1		WA	118
rs143890348^1,2		--	55211558(+)	`TACTCA/GCACTG`	5	--	int¹		0	--	--	--	--
rs114376442^1,2		--	55211637(+)	`GGTTGG/TTATTC`	5	--	int¹		1		WA	118
rs184433635^1,2		--	55211845(+)	`ACCTCC/TACTAG`	5	--	int¹		0	--	--	--	--
rs11899295^1,2	C,F,H,	--	55211884(+)	`TCCAAC/GAAGCT`	5	--	int¹		12		NS EA NA WA	1316
rs189020058^1,2		--	55212020(+)	`GAGGAC/TTGCTT`	5	--	int¹		0	--	--	--	--
rs181650758^1,2		--	55212037(+)	`AGGAGA/TTCGAG`	5	--	int¹		0	--	--	--	--
rs6545464^1,2	C,F,H,	--	55212179(+)	`GGAACT/GGTAGA`	5	--	int¹		18		NS EA NA WA CSA	820
rs147272373^1,2		--	55212184(+)	`GGTAGA/GAAATT`	5	--	int¹		0	--	--	--	--
rs79624643^1,2	F,	--	55212327(+)	`GTCTCG/ATTCTA`	5	--	int¹		1		NA	120
rs6545465^1,2	C,F,H,	--	55212337(+)	`ATTGCC/TTAGGC`	5	--	int¹		14		NS EA WA NA CSA	765
rs186376947^1,2		--	55212338(+)	`TTGCTC/TAGGCT`	5	--	int¹		0	--	--	--	--
rs115434653^1,2		--	55212426(+)	`GAATAG/ACTGGG`	5	--	int¹		1		WA	118
rs13385410^1,2	C,F,	--	55212475(+)	`tttttT/Ggtaga`	5	--	int¹		1		WA	118
rs189659748^1,2		--	55212482(+)	`TAGAGA/CTGGGA`	5	--	int¹		0	--	--	--	--
rs12464447^1,2	C,F,A,H,	--	55212495(+)	`CTCACT/CATGTT`	5	--	int¹		7		WA NA CSA EA	366
rs78402810^1,2	C,	--	55212573(+)	`TTACAG/CGCATG`	5	--	int¹		2		WA	120
rs181049017^1,2		--	55212587(+)	`CAACAC/TGTTTG`	5	--	int¹		0	--	--	--	--
rs2588516^1,2	C,F,A,H,	--	55212590(-)	`AGCCAG/AACGTG`	5	--	int¹		15		NS EA WA NA CSA	794
rs140756836^1,2		--	55212593(+)	`GTTTGA/GCTGGC`	5	--	int¹		0	--	--	--	--
rs114470934^1,2	F,	--	55212711(+)	`AAATAA/GACTTA`	5	--	int¹		1		WA	118
rs12464595^1,2	C,F,A,H,	--	55212925(+)	`CTGGAT/CCATGT`	5	--	int¹		20		NS EA NA WA CSA	1427
rs185265649^1,2		--	55213310(+)	`AGTCTA/GTAGAG`	5	--	int¹		0	--	--	--	--
rs80259661^1,2	F,	--	55213320(+)	`GGGCCG/AGTGCA`	5	--	int¹		1		WA	118
rs191159406^1,2		--	55213433(+)	`CAATGC/TAGTAA`	5	--	int¹		0	--	--	--	--
rs183479131^1,2		--	55213485(+)	`GGCCAA/GATAGT`	5	--	int¹		0	--	--	--	--
rs143560639^1,2		--	55213585(+)	`TGGCT-/GGTGTT`	5	--	int¹		0	--	--	--	--
rs150912534^1,2		--	55213629(+)	`TGCATC/TTGGCC`	5	--	int¹		0	--	--	--	--
rs186330657^1,2		--	55213818(+)	`TTTGAC/GGGGAA`	5	--	int¹		0	--	--	--	--
rs191626591^1,2		--	55213863(+)	`TCGGGC/TGTTGG`	5	--	int¹		0	--	--	--	--
rs139396644^1,2		--	55213864(+)	`CGGGCA/GTTGGT`	5	--	int¹		0	--	--	--	--
rs113816096^1,2		--	55213912(+)	`TTGTGC/TGATGA`	5	--	int¹		1		CSA	2
rs118078480^1,2	F,	--	55213921(+)	`GAAAAT/CAGTGA`	5	--	int¹		1		EA	120
rs183479829^1,2		--	55213966(+)	`ATGAGC/TTTTAT`	5	--	int¹		0	--	--	--	--
rs146594580^1,2		--	55213971(+)	`TTTTAC/TGGTAT`	5	--	int¹		0	--	--	--	--
rs111731521^1,2		--	55213999(+)	`TAAAAG/AAGAGG`	5	--	int¹		1		CSA	2
rs2580768^1,2	C,F,A,H,	--	55214015(+)	`AAACAT/CGCAGA`	5	--	int¹		27		NA NS EA WA CSA	2313
rs144069203^1,2		--	55214065(+)	`CTCCAC/TAGCAA`	5	--	int¹		0	--	--	--	--
rs146450098^1,2		--	55214068(+)	`CATAGA/CAACTA`	5	--	int¹		0	--	--	--	--
rs149041406^1,2		--	55214187(+)	`AGAAAC/TGAGAA`	5	--	int¹		0	--	--	--	--
rs188166580^1,2		--	55214262(+)	`ACGAAA/CTATCA`	5	--	int¹		0	--	--	--	--
rs192896042^1,2		--	55214275(+)	`AAGCAA/CGTTAT`	5	--	int¹		0	--	--	--	--
rs143014237^1,2		--	55214276(+)	`AGCACA/GTTATC`	5	--	int¹		0	--	--	--	--
rs148278198^1,2		--	55214320(+)	`TCAAAC/TCTACC`	5	--	int¹		0	--	--	--	--
rs182311605^1,2		--	55214370(+)	`CAATGC/TTTAAC`	5	--	int¹		0	--	--	--	--
rs186580203^1,2		--	55214532(+)	`AAAAAA/TGCATG`	5	--	int¹		0	--	--	--	--
rs191166747^1,2	C,	--	55214592(+)	`CACTAC/TTGCCA`	5	--	int¹		0	--	--	--	--
rs2580769^1,2	C,F,O,A,H,	--	55214618(+)	`TCCAGC/ACATCT`	5	--	int¹		32		NA NS EA WA CSA EU	4228
rs140361549^1,2	C,	--	55214619(+)	`CCAGAC/TATCTC`	5	--	int¹		0	--	--	--	--
rs11549898^1,2	C,F,	--	55214639(+)	`GGTGGC/GCTTCA`	10	A G	mis¹		3		NA EU	5877
rs3916038^1,2	H	--	55214653(-)	`ATCCAG/AAAATC`	10	/Q	syn¹		5		MN NS EA	604
rs148322379^1,2	C	--	55214673(+)	`CACACA/C/TCTTGT`	15	S G C	mis¹		1		NA	4552
rs201611899^1,2	C	--	55214721(+)	`GGCAAT/AGTAGG`	10	/I /F	mis¹		1		EU	1323
rs2580770^1,2	C,F,H,	--	55214912(+)	`AAAAAG/CGCTAC`	5	--	int¹		34		EA NA NS WA CSA	4374
rs184759590^1,2		--	55214938(+)	`CAAACC/TTAAAA`	5	--	int¹		0	--	--	--	--
rs190464351^1,2		--	55214978(+)	`CTAACC/TTTATA`	5	--	int¹		0	--	--	--	--
rs138159498^1,2		--	55215014(+)	`TTGTAA/TATTAG`	5	--	int¹		0	--	--	--	--
rs192905493^1,2		--	55215103(+)	`ACAATA/GATTAA`	5	--	int¹		0	--	--	--	--
rs185262375^1,2		--	55215289(+)	`CTCTAC/TTGAAA`	5	--	int¹		0	--	--	--	--
rs72910882^1,2	C,	--	55215468(+)	`ATCTTG/TGGGTT`	5	--	int¹		2		WA	120
rs111230848^1,2		--	55215483(+)	`ATCTCA/CTACAA`	5	--	int¹		2		CSA WA	120
rs6729343^1,2	H	--	55215552(+)	`ACACAC/TTAAAA`	5	--	int¹		4		NS EA	418
rs143622220^1,2		--	55215554(+)	`ACACTA/GAAATG`	5	--	int¹		0	--	--	--	--
rs189745001^1,2		--	55215564(+)	`GAGATA/GCTTCA`	5	--	int¹		0	--	--	--	--
rs181226959^1,2		--	55215574(+)	`AGTGAC/TACCAA`	5	--	int¹		0	--	--	--	--
rs6729675^1,2	C,F,A,H,	--	55215617(+)	`AGGCCG/AAGATA`	5	--	int¹		5		NS EA WA	538
rs147281670^1,2		--	55215638(+)	`ACATAC/TGAATG`	5	--	int¹		0	--	--	--	--
rs116242727^1,2	F,	--	55215651(+)

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RTN4 Gene

reticulon 4

Aliases
for RTN4 gene

Summaries
for RTN4 gene

Genomic Views
for RTN4 gene

Proteins
for RTN4 gene

Protein Domains /
Families
for RTN4 gene

Function
for RTN4 gene

Pathways & Interactions
for RTN4 gene

Drugs & Compounds
for RTN4 gene

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for RTN4 gene

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for RTN4 gene

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for RTN4 gene

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for RTN4 gene

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for RTN4 gene

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Export list of displayed genes

RTN4 Gene

reticulon 4

Aliasesfor RTN4 gene

Summariesfor RTN4 gene

Genomic Viewsfor RTN4 gene

Proteinsfor RTN4 gene

Protein Domains /Familiesfor RTN4 gene

Functionfor RTN4 gene

Pathways & Interactionsfor RTN4 gene

Drugs & Compoundsfor RTN4 gene

Transcriptsfor RTN4 gene

Expression for RTN4 gene

Orthologsfor RTN4 gene

Paralogsfor RTN4 gene

Genomic Variantsfor RTN4 gene

Aliases
for RTN4 gene

Summaries
for RTN4 gene

Genomic Views
for RTN4 gene

Proteins
for RTN4 gene

Protein Domains /
Families
for RTN4 gene

Function
for RTN4 gene

Pathways & Interactions
for RTN4 gene

Drugs & Compounds
for RTN4 gene

Transcripts
for RTN4 gene

Expression
for RTN4 gene

Orthologs
for RTN4 gene

Paralogs
for RTN4 gene

Genomic Variants
for RTN4 gene