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Aliases for RTN4 Gene

Aliases for RTN4 Gene

  • Reticulon 4 2 3 5
  • Neuroendocrine-Specific Protein C Homolog 3 4
  • Neurite Outgrowth Inhibitor 3 4
  • Foocen 3 4
  • RTN-X 3 4
  • NOGO 3 4
  • NSP 3 4
  • Neuroendocrine-Specific Protein 4
  • Neurite Growth Inhibitor 220 3
  • My043 Protein 3
  • Nogo Protein 4
  • Human NogoA 3
  • Reticulon 5 3
  • Reticulon-5 4
  • NI220/250 3
  • Nbla00271 3
  • Nbla10545 3
  • KIAA0886 4
  • RTN4-B1 3
  • RTN4-B2 3
  • NOGO-A 3
  • NSP-CL 3
  • Nogo-B 3
  • Nogo-C 3
  • RTN4-A 3
  • RTN4-C 3
  • NOGOC 3
  • ASY 3

External Ids for RTN4 Gene

Previous GeneCards Identifiers for RTN4 Gene

  • GC02M055237
  • GC02M055386
  • GC02M055173
  • GC02M055110
  • GC02M055199

Summaries for RTN4 Gene

Entrez Gene Summary for RTN4 Gene

  • This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for RTN4 Gene

RTN4 (Reticulon 4) is a Protein Coding gene. Diseases associated with RTN4 include Temporal Lobe Epilepsy and Demyelinating Disease. Among its related pathways are p75 NTR receptor-mediated signalling and Spinal Cord Injury. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is RTN1.

UniProtKB/Swiss-Prot for RTN4 Gene

  • Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.

Gene Wiki entry for RTN4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTN4 Gene

Genomics for RTN4 Gene

Regulatory Elements for RTN4 Gene

Enhancers for RTN4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RTN4 on UCSC Golden Path with GeneCards custom track

Promoters for RTN4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RTN4 on UCSC Golden Path with GeneCards custom track

Genomic Location for RTN4 Gene

Chromosome:
2
Start:
54,972,187 bp from pter
End:
55,112,621 bp from pter
Size:
140,435 bases
Orientation:
Minus strand

Genomic View for RTN4 Gene

Genes around RTN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTN4 Gene

Proteins for RTN4 Gene

  • Protein details for RTN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQC3-RTN4_HUMAN
    Recommended name:
    Reticulon-4
    Protein Accession:
    Q9NQC3
    Secondary Accessions:
    • O94962
    • Q7L7Q5
    • Q7L7Q6
    • Q7L7Q8
    • Q8IUA4
    • Q96B16
    • Q9BXG5
    • Q9H212
    • Q9H3I3
    • Q9UQ42
    • Q9Y293
    • Q9Y2Y7
    • Q9Y5U6

    Protein attributes for RTN4 Gene

    Size:
    1192 amino acids
    Molecular mass:
    129931 Da
    Quaternary structure:
    • Binds to RTN4R. Interacts with Bcl-xl and Bcl-2. Isoform 2 binds to NGBR and RTN3. Isoform 2 and isoform 3 interact with BACE1 and BACE2. Interacts with RTN4IP1. Interacts with ATL1.
    SequenceCaution:
    • Sequence=AAD39920.1; Type=Frameshift; Positions=1149, 1156; Evidence={ECO:0000305}; Sequence=AAG43160.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAG43160.1; Type=Frameshift; Positions=684, 700; Evidence={ECO:0000305}; Sequence=BAA74909.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RTN4 Gene

    Alternative splice isoforms for RTN4 Gene

neXtProt entry for RTN4 Gene

Proteomics data for RTN4 Gene at MOPED

Post-translational modifications for RTN4 Gene

  • Ubiquitination at Lys 1090 and Lys 1171
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RTN4 (Nogo)

No data available for DME Specific Peptides for RTN4 Gene

Domains & Families for RTN4 Gene

Protein Domains for RTN4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RTN4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NQC3

UniProtKB/Swiss-Prot:

RTN4_HUMAN :
  • Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane domains, known as Nogo-66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the spreading of neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity).
Domain:
  • Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane domains, known as Nogo-66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the spreading of neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity).
  • Contains 1 reticulon domain.
genes like me logo Genes that share domains with RTN4: view

No data available for Gene Families for RTN4 Gene

Function for RTN4 Gene

Molecular function for RTN4 Gene

UniProtKB/Swiss-Prot Function:
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.
genes like me logo Genes that share phenotypes with RTN4: view

Animal Models for RTN4 Gene

MGI Knock Outs for RTN4:

Animal Model Products

  • Taconic Biosciences Mouse Models for RTN4

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RTN4 Gene

Localization for RTN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTN4 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RTN4 Gene COMPARTMENTS Subcellular localization image for RTN4 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
nucleus 5
plasma membrane 5
cytoskeleton 2
cytosol 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RTN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IDA 11126360
GO:0030176 integral component of endoplasmic reticulum membrane IDA 10667797
GO:0042995 cell projection IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with RTN4: view

Pathways & Interactions for RTN4 Gene

genes like me logo Genes that share pathways with RTN4: view

Pathways by source for RTN4 Gene

1 GeneGo (Thomson Reuters) pathway for RTN4 Gene
1 Qiagen pathway for RTN4 Gene

SIGNOR curated interactions for RTN4 Gene

Activates:
Other effect:

Gene Ontology (GO) - Biological Process for RTN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process NAS 11126360
GO:0007409 axonogenesis IBA --
GO:0007413 axonal fasciculation ISS --
GO:0021801 cerebral cortex radial glia guided migration ISS --
GO:0030517 negative regulation of axon extension IDA 10667797
genes like me logo Genes that share ontologies with RTN4: view

Drugs & Compounds for RTN4 Gene

(1) Additional Compounds for RTN4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RTN4: view

Transcripts for RTN4 Gene

Unigene Clusters for RTN4 Gene

Reticulon 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RTN4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d ^ 16 ^
SP1: - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: - - - -
SP12: - - -
SP13: - - - - -
SP14: - - - - - -
SP15: - -
SP16:
SP17:
SP18:

ExUns: 17a · 17b · 17c · 17d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for RTN4 Gene

GeneLoc Exon Structure for
RTN4
ECgene alternative splicing isoforms for
RTN4

Expression for RTN4 Gene

mRNA expression in normal human tissues for RTN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RTN4 Gene



SOURCE GeneReport for Unigene cluster for RTN4 Gene Hs.637850

mRNA Expression by UniProt/SwissProt for RTN4 Gene

Q9NQC3-RTN4_HUMAN
Tissue specificity: Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis-specific.
genes like me logo Genes that share expression patterns with RTN4: view

Protein tissue co-expression partners for RTN4 Gene

- Elite partner

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for RTN4 Gene

Orthologs for RTN4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RTN4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RTN4 35
  • 91 (n)
  • 93.67 (a)
RTN4 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RTN4 35
  • 88.51 (n)
  • 83.64 (a)
RTN4 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rtn4 35
  • 83.56 (n)
  • 77.72 (a)
Rtn4 16
Rtn4 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rtn4 35
  • 83.28 (n)
  • 77.89 (a)
oppossum
(Monodelphis domestica)
Mammalia RTN4 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RTN4 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RTN4 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101749579 35
  • 60.49 (n)
  • 44.32 (a)
RTN4 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RTN4 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rtn4 35
  • 58.06 (n)
  • 49.26 (a)
Str.386 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68489 35
zebrafish
(Danio rerio)
Actinopterygii Dr.24718 35
rtn4a 36
  • 51 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8546 35
fruit fly
(Drosophila melanogaster)
Insecta CG42853 36
  • 18 (a)
ManyToMany
Rtnl1 36
  • 27 (a)
ManyToMany
Rtnl2 36
  • 22 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ret-1 36
  • 7 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTN2 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10170 36
  • 33 (a)
OneToMany
Species with no ortholog for RTN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RTN4 Gene

ENSEMBL:
Gene Tree for RTN4 (if available)
TreeFam:
Gene Tree for RTN4 (if available)

Paralogs for RTN4 Gene

Paralogs for RTN4 Gene

genes like me logo Genes that share paralogs with RTN4: view

Variants for RTN4 Gene

Sequence variations from dbSNP and Humsavar for RTN4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_035904 A colorectal cancer sample
rs11677099 - 55,027,029(+) CTTCA(A/C/T)CCTCT intron-variant, reference, missense
rs6757519 - 55,025,404(+) AATTT(C/G)ACTTT intron-variant, reference, missense
rs6757705 - 55,025,340(+) TCAAA(C/G)AAAGG intron-variant, reference, missense
rs1822616 -- 55,056,742(+) TAATT(G/T)AGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RTN4 Gene

Variant ID Type Subtype PubMed ID
esv2720078 CNV Deletion 23290073
nsv834069 CNV Loss 17160897
nsv874155 CNV Loss 21882294
esv267485 CNV Insertion 20981092
esv2517082 CNV Deletion 19546169
esv2474783 CNV Deletion 19546169

Variation tolerance for RTN4 Gene

Residual Variation Intolerance Score: 35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.11; 80.53% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RTN4 Gene

Disorders for RTN4 Gene

MalaCards: The human disease database

(8) MalaCards diseases for RTN4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
temporal lobe epilepsy
  • epilepsy, temporal lobe
demyelinating disease
  • demyelinating disorder
schizophrenia
  • schizophrenia 12
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
pedophilia
  • paedophilia
- elite association - COSMIC cancer census association via MalaCards
Search RTN4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RTN4

Genetic Association Database (GAD)
RTN4
Human Genome Epidemiology (HuGE) Navigator
RTN4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RTN4
genes like me logo Genes that share disorders with RTN4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RTN4 Gene

Publications for RTN4 Gene

  1. Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. (PMID: 10667797) GrandPre T. … Strittmatter S.M. (Nature 2000) 2 3 4 23 67
  2. Protein microarray analysis identifies cyclic nucleotide phosphodiesterase as an interactor of Nogo-A. (PMID: 19508346) Sumiyoshi K. … Satoh J. (Neuropathology 2010) 3 23
  3. The association between dilated cardiomyopathy and RTN4 3'UTR insertion/deletion polymorphisms. (PMID: 18948092) Zhou B. … Zhang L. (Clin. Chim. Acta 2009) 3 23
  4. Reticulon-4A (Nogo-A) redistributes protein disulfide isomerase to protect mice from SOD1-dependent amyotrophic lateral sclerosis. (PMID: 19889996) Yang Y.S. … Strittmatter S.M. (J. Neurosci. 2009) 3 23
  5. Identification of Nogo as a novel indicator of heart failure. (PMID: 17971502) Bullard T.A. … Blaxall B.C. (Physiol. Genomics 2008) 3 23

Products for RTN4 Gene

Sources for RTN4 Gene

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