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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RTN4 Gene

protein-coding GIFtS: 66
GCID: GC02M055199

reticulon 4

Explore 33 diseases affiliated with
RTN4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Reticulon 4¹ ²		RTN4-A²
NOGO¹ ² ³ ⁵		RTN4-B1²
ASY¹ ²		RTN4-B2²
NSP-CL¹ ²		RTN4-C²
KIAA0886¹ ³		Foocen³
Neurite Outgrowth Inhibitor² ³		Human NogoA²
Neuroendocrine-Specific Protein C Homolog² ³		My043 Protein²
NSP² ³		Neurite Growth Inhibitor 220²
NI220/250²		Reticulon 5²
NOGO-A²		Reticulon-4¹
NOGOC²		Foocen³
Nbla00271²		RTN-X²
Nbla10545²		Reticulon-5³
Nogo-B²		Neuroendocrine-Specific Protein³
Nogo-C²		Nogo Protein³
RTN-X²

External Ids:	HGNC: 14085¹	Entrez Gene: 57142²	Ensembl: ENSG00000115310⁷	OMIM: 604475⁵	UniProtKB: Q9NQC3³

Export aliases for RTN4 gene to outside databases

Previous GC identifers: GC02M055237 GC02M055386 GC02M055173 GC02M055110 GC02M054934

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RTN4:

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum,

and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this

gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system

in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and

differential promoter usage and encoding different isoforms have been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3

Function: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and

growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the

developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of

plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing

receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely

consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding

and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing

Gene Wiki entry for RTN4 (Reticulon 4)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RTN4 gene promoter:
POU2F1 POU2F1a C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 10): RTN4 promoter sequence

Search SABiosciences Chromatin IP Primers for RTN4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RTN4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.3 Ensembl cytogenetic band: 2p16.1 HGNC cytogenetic band: 2p14-p13

RTN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTN4 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M055199: view genomic region (about GC identifiers)

Start:	55,199,325 bp from pter	End:	55,339,757 bp from pter
Size:	140,433 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3 (See protein sequence)

Recommended Name: Reticulon-4

Size: 1192 amino acids; 129931 Da

Subunit: Binds to RTN4R. Interacts with Bcl-xl and Bcl-2. Isoform 2 binds to NGBR and RTN3. Isoform 2 and isoform 3

interact with BACE1 and BACE2. Interacts with RTN4IP1. Interacts with ATL1

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Anchored to the membrane of the

endoplasmic reticulum through 2 putative transmembrane domains

Sequence caution: Sequence=AAD39920.1; Type=Frameshift; Positions=1149, 1156; Sequence=AAG43160.1; Type=Erroneous

initiation; Note=Translation N-terminally extended; Sequence=AAG43160.1; Type=Frameshift; Positions=684, 700;

Sequence=BAA74909.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

2 PDB 3D structures from and Proteopedia for RTN4:

2JV5 (3D)

Secondary accessions: O94962 Q7L7Q5 Q7L7Q6 Q7L7Q8 Q8IUA4 Q96B16 Q9BXG5 Q9H212 Q9H3I3 Q9UQ42 Q9Y293

Q9Y2Y7 Q9Y5U6

Alternative splicing: 6 isoforms: Q9NQC3-1 Q9NQC3-2 Q9NQC3-3 Q9NQC3-4 Q9NQC3-5 Q9NQC3-6

Explore the universe of human proteins at neXtProt for RTN4: NX_Q9NQC3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NQC3

RTN4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_008939.1 NP_065393.1 NP_722550.1 NP_997403.1 NP_997404.1

ENSEMBL proteins:

ENSP00000378107 ENSP00000384471 ENSP00000349944 ENSP00000337838 ENSP00000322147

ENSP00000350365 ENSP00000378109 ENSP00000385650 ENSP00000397808 ENSP00000411628

ENSP00000384825 ENSP00000346465

Reactome Protein details: Q9NQC3
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for RTN4 (Nogo-A)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): RTN4 OriGene Protein Over-expression Lysate (see all 5): RTN4 OriGene Custom Protein Services for RTN4
	GenScript Custom Purified and Recombinant Proteins Services for RTN4
	Novus Biologicals RTN4 Proteins Novus Biologicals RTN4 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RTN4

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005635	nuclear envelope	IDA	11126360
GO:0005737	cytoplasm	--	--
GO:0005783	endoplasmic reticulum	NAS	11126360
GO:0005886	plasma membrane	TAS	--
GO:0030176	integral to endoplasmic reticulum membrane	IDA	10667797

RTN4 for ontologies About GeneDecksing

RTN4 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of RTN4
	R&D Systems Antibodies for RTN4 (Nogo-A, Nogo-B, Nogo-C)
	OriGene Antibodies (see all 2): RTN4 OriGene Custom Antibody Services for RTN4
	GenScript Custom Superior Antibodies Services for RTN4
	Novus Biologicals RTN4 Antibodies
	Search for Antibodies for RTN4 at Abcam
	Uscn Antibodies for RTN4
	ThermoFisher Antibodies for RTN4

Assay Products for RTN4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RTN4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RTN4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RTN4 for domains About GeneDecksing

1 InterPro domain/family:

IPR003388 Reticulon

Graphical View of Domain Structure for InterPro Entry Q9NQC3

ProtoNet protein and cluster: Q9NQC3

1 Blocks protein family: IPB003388 Reticulon

UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3

Domain: Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane domains,

known as Nogo-66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the spreading of

neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity)

Similarity: Contains 1 reticulon domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3

Function: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and

growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the

developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of

plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing

receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely

consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding

and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing

miRNA Products:		miRTarBase miRNAs that target RTN4: hsa-mir-16 (MIRT001421), hsa-mir-21 (MIRT000167)

		OriGene 3'-UTR Clone (see all 5): RTN4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RTN4
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RTN4 (see all 19):
		hsa-miR-4318 hsa-miR-15a hsa-miR-503 hsa-miR-3692 hsa-miR-424 hsa-miR-195 hsa-miR-497* hsa-miR-15b

		SwitchGear 3'UTR luciferase reporter plasmid: RTN4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RTN4 (see all 7) OriGene shRNA RFP: RTN4 OriGene siRNA: RTN4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RTN4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RTN4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RTN4 (see all 12) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RTN4 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): RTN4 (NM_020532)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RTN4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTN4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RTN4
		Search LifeMap BioReagents cell lines for RTN4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	19665976
GO:0032403	protein complex binding	--	--

RTN4 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for RTN4: Rtn4^tm1Schw Rtn4^tm2.1Matl Rtn4^tm2Matl
     4 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Rtn4):

mortality/aging

RTN4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

1

Axonal growth inhibition (RHOA activation)

Axonal growth inhibition (RHOA activation)

1.00

p75NTR regulates axonogenesis

0.90

2

Development MAG-dependent inhibition of neurite outgrowth

Development MAG-dependent inhibition of neurite outgrowth

1.00

Development_MAG-dependent inhibition of neurite outgrowth

0.87

3

NgR-p75(NTR)-Mediated Signaling

NgR-p75(NTR)-Mediated Signaling

1.00

4

p75(NTR)-mediated signaling

p75(NTR)-mediated signaling

1.00

5

Cell death signalling via NRAGE, NRIF and NADE

p75 NTR receptor-mediated signalling

0.73

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for RTN4

Development MAG-dependent inhibition of neurite outgrowth

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RTN4

NgR-p75(NTR)-Mediated Signaling

1 GeneGo (Thomson Reuters) Pathway for RTN4

Development MAG-dependent inhibition of neurite outgrowth

1 BioSystems Pathway for RTN4

p75(NTR)-mediated signaling

5 Reactome Pathways for RTN4

	Axonal growth inhibition (RHOA activation)
	Signal Transduction
	p75NTR regulates axonogenesis
	Signalling by NGF
	p75 NTR receptor-mediated signalling

RTN4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RTN4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/65 Interacting proteins for RTN4 (Q9NQC3^{1, 2, 3} ENSP00000337838⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 65)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COL4A3BP	Q9Y5P4²^,³, ENSP00000369862⁴	MINT-68370 I2D: score=5 STRING: ENSP00000369862
FXR2	P51116²^,³, ENSP00000250113⁴	MINT-67869 I2D: score=5 STRING: ENSP00000250113
CRMP1	Q14194²^,³, ENSP00000321606⁴	MINT-65114 I2D: score=4 STRING: ENSP00000321606
ABL1	P00519²^,³, ENSP00000361423⁴	MINT-8110731 I2D: score=3 STRING: ENSP00000361423
FYN	P06241²^,³, ENSP00000357656⁴	MINT-8111499 I2D: score=3 STRING: ENSP00000357656

About this table

Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0006915	apoptotic process	NAS	11126360
GO:0007399	nervous system development	--	--
GO:0007413	axonal fasciculation	ISS	--
GO:0007568	aging	--	--

RTN4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RTN4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RTN4
1 Novoseek chemical compound relationship for RTN4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ddvp	58	1	17029193 (1)

Search CenterWatch for drugs/clinical trials and news about RTN4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RTN4 gene (5 alternative transcripts):

NM_007008.2 NM_020532.4 NM_153828.2 NM_207520.1 NM_207521.1

Unigene Cluster for RTN4:

Reticulon 4

Hs.743996 [show with all ESTs]

Unigene Representative Sequence: NM_020532

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000394609(uc002ryc.3) ENST00000405240 ENST00000357376(uc002ryd.3)

ENST00000337526(uc002rye.3) ENST00000317610(uc002ryg.3) ENST00000357732(uc002ryf.3)

ENST00000394611 ENST00000404909 ENST00000486085 ENST00000491592 ENST00000485749

ENST00000438462 ENST00000427710 ENST00000461004 ENST00000402434 ENST00000354474

miRNA Products:		OriGene 3'-UTR Clone (see all 5): RTN4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RTN4
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RTN4 (see all 19):
		hsa-miR-4318 hsa-miR-15a hsa-miR-503 hsa-miR-3692 hsa-miR-424 hsa-miR-195 hsa-miR-497* hsa-miR-15b

		SwitchGear 3'UTR luciferase reporter plasmid: RTN4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RTN4 (see all 7) OriGene shRNA RFP: RTN4 OriGene siRNA: RTN4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RTN4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RTN4 (see all 12) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RTN4 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): RTN4 (NM_020532)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RTN4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTN4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RTN4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RTN4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RTN4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTN4

Additional cDNA sequence:

AB015639.1 AB020693.1 AB040462.1 AB040463.1 AB073351.1 AB073359.1 AF063601.1 AF077050.1

AF087901.1 AF125103.1 AF132047.1 AF132048.1 AF148537.1 AF148538.1 AF177332.1 AF320999.1

AF333336.1 AJ251383.1 AJ251384.1 AJ251385.1 AK075039.1 AK098385.1 AK129806.1 AK130812.1

AK172726.1 AK302741.1 AY102276.1 AY102277.1 AY102278.1 AY102279.1 AY123245.1 AY123246.1

AY123247.1 AY123248.1 AY123249.1 AY123250.1 BC001035.2 BC007109.1 BC010737.1 BC012619.1

BC014366.1 BC016165.1 BC026788.1 BC068991.1 BC071848.1 BC150182.1 BC152425.1 BC152555.1

24/70 DOTS entries (see all 70):

DT.87018236 DT.92057768 DT.91855184 DT.97862663 DT.100039375 DT.95148397 DT.100889622 DT.100039374

DT.97776594 DT.100889645 DT.100039372 DT.121021010 DT.100889631 DT.420660 DT.100889638 DT.100889649

DT.100889641 DT.100889621 DT.121021012 DT.408266 DT.95329023 DT.95128616 DT.100889636 DT.102838873

1507 AceView cDNA sequences (see top 24):

W19399 BM470283 CA421240 AU104979 AA081525 BG570231 AW169711 BM983902

T32248 AB040462 AA329816 AA911774 AI699241 AI348346 AY123250 BM709730

AI066675 AW264441 BM677436 W21129 CB108617 AW305370 AA576133 BU729639

T34690 AI309845 CB162885 BM709363 AF320999 CB148622 CB156265 W73282

AA770491 BU684302 BU685628 BQ645271 T31818 AI217084 AA331600 AI049939

AY123249 AI198742 BM699659 AK130812 W95807 CB268847 BU681578 CD723962

CA396767 AJ251384 BE302112 N73666 BF222514 BQ954553 AI189395 CB133824

CN483287 AW673265 AA058672 AU104978 AA307342 BM666337 BX439214 AA055325

R96423 CA424938 AJ251383 CB162572 AF132047 CB108215 BM670506 AI521847

AA370616 AK098385 CD216746 CB164794 BG427774 AW021468 AY123247 AY123246

AI216602 AA055921 BM826161 AA161110 AI148351 AK090714 NM_153828 AF148537

AI344411 CD368612 BF448757 BQ638521 BU154019 BX475835 AA192937 AI755241

BU952509 BU170309 AI828700 AA746210 T56065 N93723 AI684996 W95814

CB215381 CB266419 AA490449 BM469346 BM745158 AU104981 AA370615 BE349080

F24615 BF591729 AL533461 CA389096 BQ639205 AA845388 AI879953 F12499

AI581715 CB156990 CA394738 CR611869 AI707817 AA708473 AI879556 AI266279

AI536596 AA558613 BU675215 AW087571 BC010737 CN482259 AI870953 CB160548

CB147989 AW967182 AI359359 AA460519 BM764054 AA328277 AA148772 AA558599

AI423987 T51528 AL044695 AA088463 AU104985 AI963748 Z42379 AJ251385

C16034 BC026788 BQ233389 AA877014 AI424265 AA329773 BM693001 BM700397

CB148627 BE857516 NM_207520 AA322807 AI718507 CA843404 AJ709180 BM505511

AW889839 AA058790 AI537135 BM722974 NM_207521 AA554449 AI418139 AA662155

BC001035 NM_020532 AA186964 BQ878189 AA858374 AI672412 AW167214 BM552865

AY123248 BF221792 AI929022 BE349238 NM_007008 BG618709 AW239482 AV725869

AI308761 N55351 AI584157 W73227 AI687677 AW337888 CA448902 T56100

CA390392 CA417454 CA445294 AI343667 AI479834 CB054418 AI888295 CN481104

AA618573 BQ215577 W37482 CB153870 AW611554 AW089177 BM557554 CF125576

AW160716 AI280074 BE380150 AA807837 AW239261 AI083890 AB020693 AY102279

BG697436 CB145484 AU104976 BQ879359 AI568994 BG610764 BI548612 AF333336

BU732741 AI720703 AA729828 AW075649 AI967969 AI735423 BC007109 BC014366

AA878901 BG536242 BM508882 BG623462 BM998097 W69592 AI150672 BM888460

BM989279 BC016165 AA159037 BG622004 AI870021 BG402328 BU543106 AF177332

AA056175 AI796628 AW368210 BE208292 CA868554 AL705563 BG433279 BQ010273

BE254391 AA773966 CD367884 CN482846 BG287990 BF671520 BU619407 AA770147

BM821856 BM768518 CA867833 BM693520 AA056182 CA440473 BG402114 D57251

BF475798 AI888442 CB108566 AY102277 BF672379 BG502197 BM788493 BU949473

BQ477326 AW769624 BU681133 CB053971 AW732388 BQ287798 BF790444 AI797201

AI813557 BM695159 AA334328 BG740376 AA906723 BG034056 AI355339 AA262916

AI359301 BU078128 BG433955 CB117206 BU949233 BQ549482 BU146783 BI601346

BF575630 BM978839 N67593 AA971223 BE858502 BQ941451 BM792328 BF346570

AK075039 AI003453 AI423444 CA397211 AI367513 BG742400 BG370424 AV728221

F30897 AA074903 BU620297 CD706840 AA680274 CN482610 AI498373 AA236753

BQ227142 CB178361 AL038638 AA158764 BM979031 AL573494 BG402094 AV729281

BM503330 AI690528 CD641589 CD368992 BQ690950 AA578852 AI742507 Z38593

BG545286 T06696 BM552274 BQ011273 BG402650 CK004367 AA993291 AI986310

BU542102 AA111869 AA046434 AI742515 AI095245 CB956475 BQ268955 CA443905

N22319 AI834285 AL038639 AI590873 AW239226 BF673114 BM996510 BP359878

CA422030 AA757933 AA740905 BU608785 AW995369 CD102817 CA421419 CD701478

BG563079 BU166282 AI263345 CA307578 BF962206 AA878665 AI088601 BG531004

BF672014 CD678179 AW084703 BF695073 BQ271519 CD511521 BU581480 CA774468

AA810076 W47375 CN482802 BI545780 BG621472 AV709791 BU952677 BG434277

BE936259 AW631299 AA036736 BU625807 BG110801 CA308708 AA329523 CB155366

AW468088 BU581177 AA641539 BP362950 BF574636 AI834292 BM983301 BM754296

BQ417255 D55236 BM263682 BQ776482 D54816 BF673148 BF576326 BM263385

BQ477738 AA088462 BG402261 AI299972 AA747179 AA460072 BG163576 BQ016987

AI042469 BF672665 BF671862 AA046429 BU541124 BX462648 AI206539 AA132254

CB131646 BM751765 N90911 BG427986 W47376 AI922161 BM668356 BF576341

AI342599 BG698839 AI086742 AA610076 BG401219 AF087901 AA169734 BF670363

AI659466 BF695099 BM742565 BM083716 AI394510 BU632702 AA600169 CB963798

CK002872 AA196180 AI584119 CB152498 BC071848 CB139596 AW936442 CA310107

BF672647 BQ435716 AW169741 AA600232 AI348357 BI544917 BQ024937 W69406

BU950909 AI937266 AY102278 AA972228 BM995826 AA328940 AA854941 N23614

BM820458 AW302462 BG400408 BI553739 BG742303 AA555039 BU850045 AI589052

BX478699 BE702575 F12479 CD110203 CB113427 BF126207 AI919088 H89669

AI928859 CD370277 BU727926 AI589662 AI273147 D54067 AA046422 AI375171

BU077878 AI553797 AW002797 AA176619 F18902 AL526190 BM978333 W37587

CA308369 BQ719894 BQ014282 CA430139 CD743013 BC012619 AI679930 BC068991

BG699274 AF125103 BX460233 AV754040 BU942031 BQ271824 BG740561 CB142978

BQ446784 AI884936 AI344741 BF575647 AY102276 CB132621 BI223245 AW904445

BG819566 AI718384 BE866290 BX499382 BG428512 BM469019 BE301828 BU949718

N63372 BU752605 BI598753 BG706140 AU099277 AI692236 BE969918 BE018510

AB040463 N34816 CB162896 AI094949 AB015639 BE702624 AA173792 BU622881

AI307358 CF125503 BG218688 AI682462 CB148693 H95794 CA424629 AK172726

BM888393 BE278557 BQ959498 AI075411 BU688429 BM721543 AA167758 AI335341

AI342138 BX508579 CD512307 BG336658 AI457627 BU951067 AA181962 AA371486

AA180739 CK005004 BM793478 CD623553 BF576262 AI879173 BE783092 AA037020

AI031609 AI719428 BF672612 AW904459 AI279315 AF148538 BF672797 BG699748

BE763092 CA868589 CA310280 CD000871 BU623911 AI767427 BI561337 BM686366

AA946740 AI161085 AA781055 BE733819 D61184 AA303835 N81089 BG500588

CB956162 AI377479 AF132048 AV708414 AI373571 AA614121 BG398972 AI077295

AI978855 AA055913 BU625751 AA719831 BG432867 BM741866 D57614 BQ000269

AA156590 AI309275 BI547877 BQ311462 AI431837 AA873308 CB270751 BM450461

BU948636 AA235965 BM504874 AI370453 BQ001312 CA445537 AA460518 AI215739

BQ774392 R68787 AA341035 BG568630 H04836 CK001194 BE702618 BG427864

BM978430 BF575200 AI560740 BM841055 BM310869 BM504551 BQ929355 AI679159

BM475604 BM768262 AA934742 AY123245 CB143275 BI669351 BM556974 BG696431

AV701937 BG698881 BU674883 BM887793 BI838242 BG109465 AA150228 F19212

BM310571 BM742019 AI815653 AF063601 BU845601 AV703283 AW936440 CB963041

BE907696 AK129806 H04747 CD368020 BG433429 CA308887 BF528913 AI952807

CD677076 BU626517 CK005520 BM661558 BF173127 AW904443 AI299816 T82303

C15979 AA363284 AA738442 BG171242 AI566482 CN482998 BX475836 AW003863

AA113298 BF725117 AW364527 BM741491 BX452746 BF958142 BQ006939 AA192566

AW364525 CB045206 BF670829 BF750589 BG027307 AA074728 BG572373 N66793

W46998 BX492545 CB070370 AA084635 BF790995 AL533199 AW069724 AI262300

AW898230 BG427949 BG151076 BF588641 BE732617 AI801238 AA192599 D56138

BM747992 BE379711 BX508584 CD679547 BF126331 BQ269228 BF575741 W47036

T34858 BG715853 BG121948 BF571943 AA196936 BF574253 AV705560 BG249013

T30356 N67458 BF570468 BF033622 BM453518 BX955493 BF672234 BG527948

BG431372 AI499414 BF034364 BE694888 BG168165 N21186 D55096 AI911915

BF673018 BG428631 BM763522 AA526814 BF574539 BX462171 BG896626 BF575621

BF576696 BF670491 BF965794 BF207645 W46607 AI760768 F00316 BI668593

AV730997 BF693656 BM968716 CB156665 T33248 BE463949 AA459979 BM757524

BG565797 AL565037 BG484718 BG701394 AV710985 BF664718 AA533286 AW904452

AA226164 BF669794 BF694661 AI470883 AA780364 AL519013 BF672465 AW999706

BQ277270 AI432920 BG259591 BF672284 BG119018 AA599248 AW368177 AV727359

BG715173 BE702547 AI671568 BG170953 BF672159 BF574870 AI679420 AA583970

BF960407 AA084644 AA079399 BF576598 AW081816 BG210265 BF966458 BE063665

AV701931 AI268619 BM801698 BG942423 W46637 AV702687 BG427535 F36717

CB045207 BF574843 BF672860 AA018136 BG335746 CK001143 BM023600 AA069180

AA100508 BG035153 T31420 BI492425 BF791128 BM747995 BF958126 AI520812

BM998201 AA322592 D57700 BQ221546 BF575626 AA333267 AW965261 C15922

BG428585 CB054419 BI559373 BF672825 CB070311 AW889833 AL557539 BG678097

BE936286 BF695222 R68305 R68886 BF790495 BF574911 BF672709 BU948888

BM690642 BM423422 BE537668 CD369668 BE936264 AA669190 W48743 BG432186

BF574159 BE763117 AA180786 BF790867 BG387974 F10120 W44546 F35197

BF694537 CF528159 AV682540 BQ899072 BG326372 AF152899 AW936439 BF575611

AA976282 BF211359 W44555 AL549191 CK905315 BF671430 CA312856 BQ271180

BU687152 AA035431 AA079432 CB116040 CB115116 N27459 AA158011 AA236111

AW364492 T65815 BF575476 AW898312 W37994 BG942336 BG896766 BG389141

BF105281 AW020929 BM689581 BM757031 BG431787 AA301766 BM042930 BM469154

T54784 BF940199 BF575966 BF672017 BG402978 AW368178 W47581 BU681625

CK023755 F10097 AA081840 BF962890 AI920873 BF670282 AA679239 BG171634

BE906371 BG168232 CA418727 BE873739 BP362399 AA086490 R63674 BM452395

BE866495 AW965418 BM006974 BE936253 D56615 BM751836 BF671990 BF672453

AW238898 AA092565 BM661674 AA503885 BE564826 BF692913 BQ942705 BQ306117

T81016 BF673062 AA196311 AW889886 AA364756 BF673925 BF130487 BM847202

BE699380 AW023069 BM424058 BI553082 D61090 BF574822 BF670423 BF577028

W04793 BG716722 AI310147 AA096230 BF154509 AI799177 D52691 AV704209

BU948562 AA860291 AA243987 AW953958 BG506323 AV706003 BQ026250 R41535

BE618203 BU557287 F00105 BQ064666 F13676 AW853833 AI022820 BF576075

BE763144 BF574550 BQ653048 BE564325 BU073029 BF732331 BE566199 BX497982

BF695215 BF154508 BF570597 AA333196 AW162220 BE971388 BG119574 BF671585

N66444 BF214932 BF670591 BF575471 BE763794 AI830825 BF694559 BG112486

AW889887 BX355661 R68270 CB106312 AA167638 BF790838 W68781 BG939616

BG250071 R68108 BF213451 AW904449 BF670459 BF672048 AA158636 AA193274

AW904837 T56049 AL579554 AJ708077 BF671275 BF671326 T94677 CB131618

AW468515 BG502524 AW889819 BQ271479 BU153077 AA046206 AA193133 BG426667

BF576234 BF671796 BE702640 BU071016 BG122783 R62718 BF671617 AA705930

BE828318 BQ956339 BF671804 BG114469 AW898290 BF687772 T65741 BG939346

AA210750 BF691960 AV749519 AF077050 BG252025 BM559774 BF670636 BE271693

AV727456 BF673070 T51677 T89081 BQ305855 AA890714 AW020472 BF575245

BF438444 BF670790 H86166 BF671415 BE739746 BM193947 AW020291 AV726731

BF577006 AI569046 BQ690744 BF670926 BF672700 W69372 AU104982 AL120597

CA843655 BM701973 BG748728 AI828175 AA086341 BE763799 N90760 AL526343

CB155365 N21304 BM504169 BF694481 BG169436 AA729870 T74296 BF340304

AA374525 BG779489 BF209625 BF978685 BF790734 BG427424 W68688 BF694585

BF575370 BF245036 BF126405 AA095336 N56339 BQ943814 BQ305789 BQ897293

BF694869 BM912569 R78153 T71657 BE276084 BU737479 BF576923 BG750794

BG427373 BU932723 BF853994 BG715601 BE568846 BF337119 BF692821 BE927128

F37719 T89097 BQ305845 BQ305850 BU543505 W48742 BF749150 BF576606

R68156 BU146814 AA018184 BF750586 BF574724 BU159470 AW602732 BG696493

BQ306009 AV747236 BI962975 AV705918 BE815643 BF694964 BX352000 BQ312682

AW903590 BF576728 BQ305954 BG565189 T34689 BG251908 BF208011 AW148462

BF693398 BQ710673 BE765329 H43749 BI667702 BM477061 AI419103 BF693401

BF574980 BE936256 BF671114 BE568532 BG181155 BI601268 AA167645 AA046212

BF693258 BG537479 BE699411 BF575971 BF694370 AW364528 BG112192 BE960981

BX452734 BU169573 BF245381 BM808522 AA076201 BQ306498 BF672859 BE866564

BG535989 C16441 BF968889 AW894288 BQ305787 BF130582 BF693691 BF947404

BF789957 BU179657 BF575210 BE967564 BQ306496 BG620263 BF031142 BG290850

AW268665 BG107460 CB956908 AA180777 BF790889 BE699375 AW007478 BX426505

BI598524 BQ305965 CD518427 AV744811 BG426807 BG252460 BM917262 H24741

BF694374 AV741928 BF031510 AW821806 AA131123 BF576056 AA055955 BQ312115

BF576128 R96380 BF670649 BF877790 BX421662 BF693272 AA074192 BG938827

BM555265 CB958303 BF575253 AA252742 BQ305815 AI091717 CB106678 CB109555

AA173844 BQ307250 H96142 BQ306098 AA912471 BF693087 BF671762 BM562184

AA122208 BQ338261 BG546823 AW952444 BG427896 T94336 N24589 BF671250

BQ305989 BG477689 N23613 BF576176 T94690 BF577181 R54217 CB999040

BE937602 BE738965 BU950008 BQ306120 BF674000 BE080807 BE007854 BE702567

R70590 AL519012 BF791087 BQ306018 BE878316 AI125763 BE301417 BF789989

BG750920 BQ305991 CA867795 AA192565 BF692987 BE738856 BF126139 H26582

BF790642 BF081925 BF671115 BQ437937 BF247561 AW999913 AW904777 BG697044

BX425693 BG285440 BG253629 N31239 T81226 BE738986 BF694889 BG830985

CB216045 BF947407 BF790651 H77815 BI598065 T54675 BG335711 AA179675

BF671309 AA167765 BG492550 BQ070754 BF695292 BF692911 BQ306103 AA249483

BQ305977 BQ305959 BF574531 R70605 BQ305966 BI600556 T71810 BF570751

BG419703 BF734642 BM811041 BF952838 N66631 AW020481 AW769788 BF574983

R51821 BQ305936 BF208829 BQ690567 BM352482 BG114654 AW021375 BF699457

W19258 BE620217 BF693339 AA729509 BG426803 BE183308 AA074467 BG111847

BE878382 BF789901 AI016068 BG425264 N77358 CB955703 BE769577 BQ305941

AW798234 AI906771 BQ306123 BQ691804 BE000272 BG338686 BE874623 BX417670

BQ305962 BI010843 BQ318283 BF667857 BE878445 BE183143 BE172028 BF854815

BF853455 H24742 BM504391 BF693360 BG470542 BE259158 R57784 BQ365871

BU963350 BF029400 AW869194 BF791266 AA074698 CF994031 BF672274 BF084251

BF692868 R18550 BU608214 BG395929 AW602720 AI370548 BQ929066 BF576643

BE080952 BE173148 BG260832 CD356979 BG106936 BE568759 CK000170 BE843286

AI222638 AI873081 BX452747 AA180908 BG009006 CB963179 W69373 BF575764

BG113256 CB999216 BE874628 AV712157 BQ277751 BM560071 BG271724 AA213809

BQ225231 BF127502 AI745516 BE000268 BF030081 BM915400 BF951041 BG426322

H77859 C14200 BM012637

GeneLoc Exon Structure

5/18 Alternative Splicing Database (ASD) splice patterns (SP) for RTN4 (see all 18) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15a	·	15b	·	15c	·	15d	^	16	^
SP1:			-		-		-		-		-		-		-		-		-		-						-		-		-								-				-		-
SP2:									-		-		-		-		-		-		-						-		-		-								-				-		-
SP3:													-		-		-		-		-						-		-		-								-				-		-
SP4:																	-		-		-						-		-		-								-				-		-
SP5:																			-		-						-		-		-								-				-		-

ExUns:	17a	·	17b	·	17c	·	17d
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for RTN4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RTN4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATGCCACA

About this image

RTN4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Anatomical compartment

Positive expression

In-situ hybridization

Eye

Expression:

Positive

Negative

cell-identifying gene

Selective marker

Experimental details:

Curated

High-throughput

Microarrays

In-situ hybridization

See RTN4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RTN4

SOURCE GeneReport for Unigene cluster: Hs.743996

UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3

Tissue specificity: Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle.

Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes.

Isoform 4 is testis-specific

SABiosciences Expression via Pathway-Focused PCR Arrays including RTN4:

Neurogenesis in human mouse rat

Nephrotoxicity in human mouse rat

Apoptosis 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RTN4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RTN4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RTN4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTN4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RTN4 gene from 5/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RTN4¹	reticulon 4	65.24(n) 54.37(a)		378790 XM_003640893.1 XP_003640941.1
lizard (Anolis carolinensis)	Reptilia	RTN4⁶	--	45(a)	1 ↔ 1	1(263837302-263900362)
African clawed frog (Xenopus laevis)	Amphibia	MGC68489²	hypothetical protein MGC68489	78.12(n)		BC059960.1
zebrafish (Danio rerio)	Actinopterygii	Dr.24718²	Transcribed sequence with weak similarity to protein more	74.33(n)		57038777
fruit fly (Drosophila melanogaster)	Insecta	Rtnl2⁶ Rtnl1⁶ (see all 3)	Rtnl1 (see all 3)	24(a) 23(a) (see all 3)	possible ortholog 1 ↔ many (see all 3)	3R(3354586-3355963) 2L(4992808-5009720)

ENSEMBL Gene Tree for RTN4 (if available)
TreeFam Gene Tree for RTN4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RTN4 gene

RTN3² RTN1² RTN2²

6 SIMAP similar genes for RTN4 using alignment to 10 protein entries: RTN4_HUMAN (see all proteins):

NOGOC Nbla10545 Nbla00271 RTN3 RTN1 RTN2

RTN4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150500955^1,2		--	55198856(+)	`CATGTC/TTGCCT`	6	--	ut3¹ ds500¹		0	--	--	--	--
rs77408068^1,2	F,	--	55198935(+)	`CGATTA/GATGAT`	6	--	ds500¹ ut3¹		1		WA	118
rs78708827^1,2		--	55199052(+)	`CTGCAC/GTGTAT`	6	--	ut3¹ ds500¹		1		NA	120
rs887^1,2	C,F,O,A,H,	--	55199068(-)	`TTAACT/CCACAT`	6	--	ds500¹ ut3¹		35		MN EA NA NS WA CSA	5199
rs80098385^1,2	F,	--	55199090(+)	`ATGAAT/ATTATT`	6	--	ut3¹ ds500¹		1		WA	118
rs191098487^1,2		--	55199112(+)	`AAACAC/TATCAC`	6	--	ut3¹ ds500¹		0	--	--	--	--
rs3839054^1,2	C	--	55199171(-)	`AACAA-/AAGTCAA`	6	--	ds500¹		0	--	--	--	--
rs58923960^1,2	C,	--	55199171(+)	`TTGAC-/TTTTGTT`	6	--	ds500¹		0	--	--	--	--
rs183285861^1,2		--	55199184(+)	`CCACAA/GTAAAC`	6	--	ds500¹		0	--	--	--	--
rs138875610^1,2		--	55199186(+)	`ACAGT-/AAAC AAACA`	6	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RTN4 (55199325 - 55339757 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RTN4
2 CNVs: 97862 97861

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RTN4

DNA2.0 Custom Variant and Variant Library Synthesis for RTN4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RTN4 for disorders           About GeneDecksing

OMIM gene information: 604475    OMIM disorders: --

20/33 diseases for RTN4 (see all 33):    About MalaCards

inclusion body myositis ventricular septal defect amyotrophic lateral sclerosis temporal lobe epilepsy

pathological gambling cerebral artery occlusion lateral sclerosis cerebrovascular accident

aortic aneurysm adult t-cell leukemia multiple sclerosis dilated cardiomyopathy

neurodegenerative disease myositis leukemia/lymphoma cardiomyopathy

bipolar disorder pulmonary hypertension t-cell leukemia alzheimer's disease

3 diseases from the University of Copenhagen DISEASES database for RTN4:

Amyotrophic lateral sclerosis Multiple sclerosis Cerebrovascular accident

10/12 Novoseek disease relationships for RTN4 gene (see all 12) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
amyotrophic lateral sclerosis	60.8	15	15786457 (3), 18419791 (2), 12270696 (1), 19889996 (1) (see all 9)
epilepsy temporal lobe	33.9	4	15619232 (1), 15245492 (1), 16772867 (1), 17439704 (1)
neurodegenerative diseases	32.4	1	14644040 (1)
schizophrenia	24.9	28	12425946 (5), 15234466 (4), 17022955 (3), 14741411 (2) (see all 8)
scar	24	3	11597097 (1), 16646157 (1), 15566408 (1)
multiple sclerosis	20.1	7	14644040 (2), 18495952 (2), 20437585 (1), 17356385 (1) (see all 5)
small cell lung cancer	17.9	1	11494121 (1)
tumors	5.29	6	17592524 (2), 12510146 (1), 11891768 (1), 18685489 (1)
cancer	5.21	5	12510146 (2), 11494121 (2), 15781961 (1)
neurological disorders	3.72	2	14644040 (2)

Genetic Association Database (GAD): RTN4
Human Genome Epidemiology (HuGE) Navigator: RTN4 (10 documents)

Export disorders for RTN4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RTN4 gene, integrated from 9 sources (see all 210):
(articles sorted by number of sources associating them with RTN4)

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Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. (PubMed id 10667797)^{1, 2, 3, 9} GrandPre T.... Strittmatter S.M. (2000)
Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping. (PubMed id 10773680)^{1, 2, 3} Yang J.... Zhao S.-Y. (2000)
Genomic structure and functional characterisation of the promoters of human and mouse nogo/rtn4. (PubMed id 12488097)^{1, 2, 9} Oertle T.... Schwab M.E. (2003)
No association between the genetic polymorphisms within RTN4 and schizophrenia in the Chinese population. (PubMed id 15234466)^{1, 4, 9} Chen W....He L. (2004)
Nogo CAA 3'UTR Insertion polymorphism is not associated with Schizophrenia nor with bipolar disorder. (PubMed id 15820318)^{1, 4, 9} Gregorio S.P....Dias-Neto E. (2005)
Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration. (PubMed id 11891768)^{1, 2, 9} Ng C.E.L. and Tang B.L. (2002)
Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. (PubMed id 16835300)^{1, 2, 9} Miao R.Q.... Sessa W.C. (2006)
CAA insertion polymorphism in the 3'UTR of Nogo gene on 2p14 is not associated with schizophrenia. (PubMed id 15661375)^{1, 4, 9} Xiong L....Joober R. (2005)
Nogo 3'-untranslated region CAA insertion: failure to replicate association with schizophrenia and demonstration of marked population difference in frequency of the insertion. (PubMed id 14741411)^{1, 4, 9} Covault J....Kranzler H. (2004)
Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein. (PubMed id 16965550)^{1, 2, 9} Murayama K.S.... Araki W. (2006)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57142	HGNC: 14085	AceView: RTN4	Ensembl:ENSG00000115310	euGenes: HUgn57142
ECgene: RTN4	H-InvDB: RTN4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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Name	Description
PharmGKB entry for RTN4	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RTN4	Genetics and Cytogenetics in Oncology and Haematology
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=R&genename=RTN4+%40+NOGO
Protein Spotlight	http://web.expasy.org/spotlight/back_issues/sptlt069.shtml

Intellectual Property for RTN4 gene
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