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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RTN4 Gene

protein-coding   GIFtS: 68
GCID: GC02M055199

Reticulon 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Reticulon 41 2     RTN4-B12
NOGO2 3 5     RTN4-B22
Neurite Outgrowth Inhibitor2 3     RTN4-C2
Neuroendocrine-Specific Protein C Homolog2 3     foocen2
NSP2 3     Human NogoA2
ASY2     My043 Protein2
NI220/2502     Neurite Growth Inhibitor 2202
NOGO-A2     Reticulon 52
NOGOC2     reticulon-42
NSP-CL2     Foocen3
Nbla002712     KIAA08863
Nbla105452     RTN-x3
Nogo-B2     Reticulon-53
Nogo-C2     Neuroendocrine-Specific Protein3
RTN-X2     Nogo Protein3
RTN4-A2     

External Ids:    HGNC: 140851   Entrez Gene: 571422   Ensembl: ENSG000001153107   OMIM: 6044755   UniProtKB: Q9NQC33   

Export aliases for RTN4 gene to outside databases

Previous GC identifers: GC02M055237 GC02M055386 GC02M055173 GC02M055110 GC02M054934


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RTN4 Gene:
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic
reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The
product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the
central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from
differential splicing and differential promoter usage and encoding different isoforms have been identified.
(provided by RefSeq, Jul 2008)

GeneCards Summary for RTN4 Gene: 
RTN4 (reticulon 4) is a protein-coding gene. Diseases associated with RTN4 include pathological gambling, and ventricular septal defect, and among its related super-pathways are p75NTR regulates axonogenesis and Development MAG-dependent inhibition of neurite outgrowth. GO annotations related to this gene include protein binding. An important paralog of this gene is RTN3.

UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3
Function: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion
and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension
in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction
of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing
receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is
likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum,
after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein
processing

Gene Wiki entry for RTN4 (Reticulon 4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RTN4 gene promoter:
         POU2F1   POU2F1a   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 10): RTN4 promoter sequence
   Search SABiosciences Chromatin IP Primers for RTN4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RTN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.3   Ensembl cytogenetic band:  2p16.1   HGNC cytogenetic band: 2p14-p13

RTN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTN4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M055199:  view genomic region     (about GC identifiers)

Start:
55,199,325 bp from pter      End:
55,339,757 bp from pter
Size:
140,433 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3 (See protein sequence)
Recommended Name: Reticulon-4  
Size: 1192 amino acids; 129931 Da
Subunit: Binds to RTN4R. Interacts with Bcl-xl and Bcl-2. Isoform 2 binds to NGBR and RTN3. Isoform 2 and isoform
3 interact with BACE1 and BACE2. Interacts with RTN4IP1. Interacts with ATL1
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Anchored to the membrane
of the endoplasmic reticulum through 2 putative transmembrane domains
Sequence caution: Sequence=AAD39920.1; Type=Frameshift; Positions=1149, 1156; Sequence=AAG43160.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAG43160.1; Type=Frameshift; Positions=684, 700;
Sequence=BAA74909.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for RTN4:
2G31 (3D)        2JV5 (3D)    
Secondary accessions: O94962 Q7L7Q5 Q7L7Q6 Q7L7Q8 Q8IUA4 Q96B16 Q9BXG5 Q9H212 Q9H3I3 Q9UQ42
Q9Y293 Q9Y2Y7 Q9Y5U6
Alternative splicing: 6 isoforms:  Q9NQC3-1   Q9NQC3-2   Q9NQC3-3   Q9NQC3-4   Q9NQC3-5   Q9NQC3-6   

Explore the universe of human proteins at neXtProt for RTN4: NX_Q9NQC3

Explore proteomics data for RTN4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NQC3

  • RTN4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RTN4 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_008939.1  NP_065393.1  NP_722550.1  NP_997403.1  NP_997404.1  

    ENSEMBL proteins: 
     ENSP00000378107   ENSP00000384471   ENSP00000349944   ENSP00000337838   ENSP00000322147  
     ENSP00000350365   ENSP00000378109   ENSP00000385650   ENSP00000397808   ENSP00000411628  
     ENSP00000384825   ENSP00000346465  
    Reactome Protein details: Q9NQC3
    Human Recombinant Protein Products for RTN4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for RTN4 (Nogo-A)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for RTN4
    OriGene Protein Over-expression Lysate for RTN4
    OriGene MassSpec for RTN4 
    OriGene Custom Protein Services for RTN4
    GenScript Custom Purified and Recombinant Proteins Services for RTN4
    Novus Biologicals RTN4 Proteins
    Novus Biologicals RTN4 Lysates
    Sino Biological Recombinant Protein for RTN4
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RTN4 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IDA11126360
    GO:0005783endoplasmic reticulum NAS11126360
    GO:0005886plasma membrane TAS--
    GO:0030176integral to endoplasmic reticulum membrane IDA10667797
    GO:0042995cell projection IEA--

    RTN4 for ontologies           About GeneDecksing



    RTN4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RTN4
    R&D Systems Antibodies for RTN4 (Nogo-A, Nogo-B, Nogo-C)
    OriGene Antibodies for RTN4
    OriGene Custom Antibody Services for RTN4
    GenScript Custom Superior Antibodies Services for RTN4
    Novus Biologicals RTN4 Antibodies
    Abcam antibodies for RTN4
    Cloud-Clone Corp. Antibodies for RTN4 
    ThermoFisher Antibodies for RTN4
    LSBio Antibodies in human, mouse, rat for RTN4 

    Assay Products for RTN4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RTN4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RTN4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RTN4 
    Cloud-Clone Corp. CLIAs for RTN4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003388 Reticulon

    Graphical View of Domain Structure for InterPro Entry Q9NQC3

    ProtoNet protein and cluster: Q9NQC3

    1 Blocks protein domain: IPB003388 Reticulon

    UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3
    Domain: Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane
    domains, known as Nogo-66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the
    spreading of neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity)
    Similarity: Contains 1 reticulon domain


    RTN4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RTN4_HUMAN, Q9NQC3
    Function: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion
    and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension
    in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction
    of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing
    receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is
    likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum,
    after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein
    processing

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11126360
         
    RTN4 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Rtn4):
     cellular  mortality/aging  nervous system  normal 

    RTN4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RTN4: Rtn4tm1Schw Rtn4tm2.1Matl Rtn4tm2Matl

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RTN4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RTN4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RTN4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RTN4 

    miRNA
    Products:
        
    miRTarBase miRNAs that target RTN4:
    hsa-mir-16 (MIRT001421), hsa-mir-21 (MIRT000167)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RTN4
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RTN4 (see all 19):
    hsa-miR-4318 hsa-miR-15a hsa-miR-503 hsa-miR-3692 hsa-miR-424 hsa-miR-195 hsa-miR-497* hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidRTN4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RTN4
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of RTN4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RTN4 (see all 32)
    OriGene ORF clones in mouse, rat for RTN4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): RTN4 (NM_020532)
    Sino Biological Human cDNA Clone for RTN4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RTN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTN4
    Sirion Biotech Customized lentivirus for stable overexpression of RTN4 
                         Customized lentivirus expression plasmids for stable overexpression of RTN4 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for RTN4
    Search LifeMap BioReagents cell lines for RTN4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RTN4 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Axonal growth inhibition (RHOA activation)
    Axonal growth inhibition (RHOA activation)0.90
    p75NTR regulates axonogenesis0.90
    2Development MAG-dependent inhibition of neurite outgrowth
    Development MAG-dependent inhibition of neurite outgrowth0.87
    3Cell death signalling via NRAGE, NRIF and NADE
    p75 NTR receptor-mediated signalling0.73
    4Signaling by FGFR
    Signalling by NGF0.71
    5Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RTN4
        Development MAG-dependent inhibition of neurite outgrowth

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RTN4
        NgR-p75(NTR)-Mediated Signaling

    1 GeneGo (Thomson Reuters) Pathway for RTN4
        Development MAG-dependent inhibition of neurite outgrowth

    2 BioSystems Pathways for RTN4
        Spinal Cord Injury
    p75(NTR)-mediated signaling


    5        Reactome Pathways for RTN4
        Axonal growth inhibition (RHOA activation)
    Signal Transduction
    p75NTR regulates axonogenesis
    Signalling by NGF
    p75 NTR receptor-mediated signalling



    RTN4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RTN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/67 Interacting proteins for RTN4 (Q9NQC31, 2, 3 ENSP000003378384) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000236693P044402, 3, ENSP000004141964MINT-8258153 I2D: score=2 STRING: ENSP00000414196
    ENSG00000237710P044402, 3, ENSP000003892884MINT-8258153 I2D: score=2 STRING: ENSP00000389288
    ENSG00000215048P044402, 3MINT-8258153 I2D: score=2 
    ENSG00000226826P044402, 3MINT-8258153 I2D: score=2 
    ENSG00000230763P044402, 3MINT-8258153 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006915apoptotic process NAS11126360
    GO:0007399nervous system development ----
    GO:0007413axonal fasciculation ISS--
    GO:0021801cerebral cortex radial glia guided migration ISS--

    RTN4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RTN4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RTN4

    1 Novoseek inferred chemical compound relationship for RTN4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ddvp 58 1 17029193 (1)

    Search CenterWatch for drugs/clinical trials and news about RTN4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RTN4 gene (5 alternative transcripts): 
    NM_007008.2  NM_020532.4  NM_153828.2  NM_207520.1  NM_207521.1  

    Unigene Cluster for RTN4:

    Reticulon 4
    Hs.637850  [show with all ESTs]
    Unigene Representative Sequence: NM_020532
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394609(uc002ryc.3) ENST00000405240 ENST00000357376(uc002ryd.3)
    ENST00000337526(uc002rye.3) ENST00000317610(uc002ryg.3) ENST00000357732(uc002ryf.3)
    ENST00000394611 ENST00000404909 ENST00000486085 ENST00000491592 ENST00000485749
    ENST00000438462 ENST00000427710 ENST00000461004 ENST00000402434 ENST00000354474


    miRNA
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    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RTN4 (see all 19):
    hsa-miR-4318 hsa-miR-15a hsa-miR-503 hsa-miR-3692 hsa-miR-424 hsa-miR-195 hsa-miR-497* hsa-miR-15b
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    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTN4
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    Additional mRNA sequence: 

    AB015639.1 AB020693.1 AB040462.1 AB040463.1 AB073351.1 AB073359.1 AF063601.1 AF077050.1 
    AF087901.1 AF125103.1 AF132047.1 AF132048.1 AF148537.1 AF148538.1 AF177332.1 AF320999.1 
    AF333336.1 AJ251383.1 AJ251384.1 AJ251385.1 AK075039.1 AK098385.1 AK129806.1 AK130812.1 
    AK172726.1 AK302741.1 AY102276.1 AY102277.1 AY102278.1 AY102279.1 AY123245.1 AY123246.1 
    AY123247.1 AY123248.1 AY123249.1 AY123250.1 BC001035.2 BC007109.1 BC010737.1 BC012619.1 
    BC014366.1 BC016165.1 BC026788.1 BC068991.1 BC071848.1 BC150182.1 BC152425.1 BC152555.1 
    DQ778739.1 

    24/70 DOTS entries (see all 70):

    DT.87018236  DT.92057768  DT.91855184  DT.100039375  DT.97862663  DT.95148397  DT.100889622  DT.97776594 
    DT.100039374  DT.100889645  DT.100039372  DT.121021010  DT.100889631  DT.420660  DT.100889638  DT.100889649 
    DT.100889641  DT.100889621  DT.121021012  DT.408266  DT.95128616  DT.95329023  DT.100889636  DT.102838873 

    1507 AceView cDNA sequences (see top 24):

    AA746210 AA370616 CB164794 AA192937 W19399 BF448757 BQ638521 AA331600 
    BF591729 CB162885 AJ251384 W73282 CB108617 BU729639 AU104978 AY123247 
    BU952509 W21129 CB133824 AI217084 BM709363 AA058672 W95807 AL533461 
    CA389096 BQ639205 AA845388 AI879953 F12499 AI581715 CB156990 CA394738 
    CR611869 AI707817 AA708473 AI879556 AI266279 AI536596 AA558613 BU675215 
    AW087571 BC010737 AI870953 CB160548 CN482259 CB147989 AW967182 AI359359 
    AA460519 BM764054 AA328277 AA148772 AA558599 T51528 AI423987 AA088463 
    AL044695 AU104985 Z42379 AJ251385 AI963748 C16034 BC026788 AA877014 
    BQ233389 AI424265 AA329773 BM693001 BM700397 CB148627 BE857516 NM_207520 
    AA322807 AI718507 AJ709180 CA843404 BM505511 AW889839 AA058790 AI537135 
    BM722974 AA554449 NM_207521 T31818 BQ954553 AI189395 BM709730 AI066675 
    AW264441 NM_153828 AK130812 CB215381 AI216602 T56065 AF132047 BG570231 
    T32248 BM677436 CD723962 AA307342 N93723 AI309845 T34690 BE349080 
    BF222514 N73666 BU681578 BM469346 BQ645271 AA370615 AA576133 AI198742 
    CB162572 BU170309 AI828700 AI755241 AA055921 BM699659 BM983902 R96423 
    BM666337 AI418139 AA662155 BC001035 NM_020532 AA186964 BQ878189 AA858374 
    AI672412 AW167214 BM552865 AY123248 AI929022 BF221792 BE349238 NM_007008 
    BG618709 AW239482 AV725869 AI308761 N55351 AI584157 AI687677 AW337888 
    W73227 CA448902 T56100 CA390392 CA417454 CA445294 AI343667 AI479834 
    AI888295 CB054418 CN481104 AA618573 BQ215577 CB153870 W37482 AW611554 
    AW089177 CF125576 BM557554 AW160716 AI280074 BE380150 AA807837 AW239261 
    AI083890 AB020693 AY102279 BG697436 AU104976 CB145484 AW673265 BM470283 
    AW021468 AW169711 AI148351 AA161110 AY123246 BM826161 AJ251383 BU154019 
    BX475835 AB040462 AA329816 AI699241 AA911774 AI348346 AY123250 W95814 
    AU104981 CB156265 BU684302 AF320999 BM670506 AA055325 BU685628 AI521847 
    BG427774 AW305370 CB266419 AI684996 F24615 BE302112 CB268847 AY123249 
    AK098385 BX439214 AF148537 AA490449 BM745158 AA770491 AI344411 CA424938 
    AA081525 CD368612 AU104979 CA421240 CB148622 AI049939 AK090714 CD216746 
    CA396767 CN483287 CB108215 AI590873 BU166282 CB053971 BM788493 AI813557 
    BP362950 BG610764 AI568994 BQ879359 CA774468 AA810076 W47375 AW468088 
    CB155366 BQ011273 BF575630 BQ549482 CB108566 BM503330 BU608785 BM754296 
    BF346570 BF574636 BF672379 AW769624 AA111869 AL573494 AI299972 BG402261 
    AA747179 AA460072 BG163576 BQ016987 AI042469 BF672665 BF671862 BU541124 
    BX462648 AA046429 AA132254 AI206539 CB131646 BM751765 N90911 BG427986 
    BF576341 AI922161 W47376 BM668356 AI342599 BG698839 AI086742 AA610076 
    AF087901 BG401219 BF670363 AA169734 AI659466 BF695099 BM742565 BM083716 
    AI394510 AA600169 AA196180 BU632702 CK002872 CB963798 CB152498 AI584119 
    AW936442 BC071848 CB139596 BF672647 BQ435716 CA310107 AA600232 AW169741 
    BI544917 AI348357 BQ024937 W69406 AI937266 BU950909 AY102278 AA972228 
    BM995826 AA854941 AA328940 N23614 BM820458 AA555039 BG742303 BX478699 
    AW302462 BG400408 BI553739 AI589052 BU850045 BE702575 CD110203 F12479 
    CB113427 BF126207 AI919088 H89669 CD370277 AI928859 AI589662 BU727926 
    AI273147 D54067 AA046422 AI375171 BU077878 AW002797 AI553797 F18902 
    AL526190 AA176619 BM978333 W37587 CA308369 BQ719894 CA430139 BQ014282 
    CD743013 AI679930 BC012619 BG699274 BC068991 AF125103 BX460233 AV754040 
    BQ271824 BU942031 BG740561 CB142978 BQ446784 AI344741 BF575647 AI884936 
    AY102276 BI223245 CB132621 AW904445 AI718384 BE866290 BG819566 BX499382 
    BG428512 BM469019 BU949718 BE301828 N63372 BU752605 BI598753 BG706140 
    AI692236 AU099277 BE969918 N34816 BE018510 CB162896 AB040463 AI094949 
    AA173792 AB015639 BE702624 BU622881 AI307358 CF125503 BG218688 AI682462 
    CB148693 CA424629 AK172726 BM888393 H95794 BE278557 CA397211 BM695159 
    BU949473 AA906723 BQ477326 BU620297 AI003453 AI359301 AA088462 BF576326 
    BG034056 BQ690950 AI742507 CD641589 AA578852 CD368992 BQ477738 CN482846 
    CD367884 BF671520 BG287990 BU619407 BM821856 AA770147 CA867833 BM768518 
    BM693520 CA422030 AA993291 D54816 BE858502 CK004367 AV729281 BG370424 
    BG402094 AA334328 AI498373 BM888460 BM979031 AI355339 CA307578 AA262916 
    BG742400 AA740905 BG740376 AW995369 AA641539 AA046434 BQ417255 BG433955 
    BG402114 AI075411 BQ959498 BM721543 BU688429 AA167758 AI335341 BX508579 
    AI342138 CD512307 BG336658 AA181962 AI457627 BU951067 AA371486 AA180739 
    CK005004 CD623553 BM793478 BF576262 BE783092 AI879173 AI031609 AA037020 
    AI719428 BF672612 AF148538 BF672797 AI279315 AW904459 CA868589 BE763092 
    CA310280 BG699748 CD000871 BU623911 AI767427 BI561337 BM686366 AA946740 
    AI161085 AA781055 BE733819 D61184 AA303835 AI377479 N81089 BG500588 
    CB956162 AF132048 AV708414 AI373571 BG398972 AA614121 AI077295 AI978855 
    BU625751 AA055913 BM741866 AA719831 BG432867 AI309275 AA156590 BQ000269 
    D57614 BI547877 BQ311462 AA873308 AI431837 CB270751 AA235965 BU948636 
    BM450461 BM504874 BQ001312 AI370453 CA445537 AI215739 AA460518 BQ774392 
    R68787 AA341035 BG568630 CK001194 H04836 BM978430 BG427864 BE702618 
    BF575200 BM841055 AI560740 BM310869 BQ929355 AI679159 BM504551 AA934742 
    BM475604 BM768262 BI669351 AY123245 CB143275 BG696431 BM556974 BU674883 
    BI838242 AV701937 BM887793 BG698881 BG109465 AA150228 F19212 BM742019 
    BM310571 AI815653 AV703283 BU845601 AW936440 AF063601 CB963041 BE907696 
    AK129806 H04747 CD368020 BF528913 CA308887 BG433429 AW904443 AI952807 
    CD677076 BU626517 CK005520 BF173127 BM661558 AI299816 T82303 C15979 
    AA363284 BG171242 AA738442 CN482998 AI566482 BX475836 AW003863 AA113298 
    BF725117 BQ227142 BQ268955 CD511521 CD701478 AF333336 BF695073 AI742515 
    BG622004 AI263345 AW239226 Z38593 AL038639 AY102277 BC016165 BI545780 
    BG621472 CN482802 AV709791 BU952677 BG434277 BE936259 AW631299 CA308708 
    AA036736 BU625807 AA329523 BG110801 BU581177 BF962206 T06696 AI870021 
    BG402328 AF177332 AA056175 AI796628 AW368210 BE208292 BG433279 CA868554 
    AL705563 BE254391 BQ010273 AA773966 W69592 AI834292 BG531004 BM989279 
    BI548612 BI601346 BF673148 AA971223 BM263682 AA074903 AW732388 BM978839 
    AI423444 BU543106 BM792328 AI797201 AA680274 BU681133 AI986310 BF475798 
    BG545286 BG502197 AA878665 BQ776482 AI088601 BU732741 CB178361 AI095245 
    BU542102 BF673114 AK075039 BQ287798 CB956475 BF672014 AI690528 BG563079 
    CA421419 AA757933 AI834285 AV728221 AA159037 F30897 D57251 CA440473 
    BU078128 CD102817 N67593 AW084703 BU581480 BM996510 BM263385 CB117206 
    AA056182 BG402650 CD706840 AL038638 BM983301 AI888442 CN482610 BF790444 
    BQ941451 BM552274 BM998097 BM508882 AI150672 BG623462 AA878901 BC007109 
    BG536242 AI967969 AI735423 BQ271519 BC014366 CD678179 BU146783 AW075649 
    N22319 CA443905 AI720703 BP359878 AA158764 D55236 AI367513 BU949233 
    AA236753 AA729828 BG428631 AA599248 BQ277270 BM741491 BF958142 AW364527 
    BX452746 AI432920 BF576696 N67458 BF965794 AA084635 BG170953 AV705560 
    BF574253 BF575741 BF126331 BF672234 F00316 BF574870 AA583970 AI679420 
    AA084644 BF960407 AA079399 BG210265 BF576598 AW081816 BF966458 BE063665 
    AV701931 AI268619 BM801698 W46637 BG942423 AV702687 BG427535 CB045207 
    F36717 BF672860 BF574843 AA018136 BG335746 CK001143 AA100508 BM023600 
    AA069180 BG035153 T31420 BI492425 BF791128 BF958126 BM747995 AI520812 
    AA322592 BM998201 D57700 BQ221546 BF575626 AA333267 AW965261 C15922 
    BG428585 CB054419 BI559373 BF672825 CB070311 AW889833 AL557539 BG678097 
    BE936286 BF695222 R68305 R68886 BF790495 BF574911 BF672709 BU948888 
    BM690642 BM423422 CD369668 BE537668 BE936264 W48743 AA669190 BG432186 
    BF034364 BG715853 BG168165 AW999706 BE694888 AI499414 BF574539 AA526814 
    BG121948 BF672159 AI262300 AW898230 BE463949 AV710985 BX955493 BF207645 
    BF672465 W46998 BF588641 D55096 BM747992 AI911915 BF669794 BF571943 
    W46607 BF673018 AI470883 AV730997 BQ006939 AA459979 BI668593 CD679547 
    BG427949 AV727359 BG151076 T30356 BF570468 AI801238 BF574159 BE763117 
    AA180786 BG387974 BF790867 W44546 F10120 F35197 BF694537 CF528159 
    BQ899072 AV682540 BG326372 AW936439 AF152899 BF575611 BF211359 CK905315 
    AA976282 AL549191 W44555 BF671430 CA312856 BQ271180 BU687152 N27459 
    AA079432 CB116040 AA035431 CB115116 AA236111 AA158011 T65815 AW364492 
    BF575476 AW898312 W37994 BG942336 BG896766 BG389141 BF105281 BM689581 
    AW020929 AA301766 BM757031 BG431787 BM042930 BM469154 T54784 BF940199 
    BF672017 BF575966 BG402978 AW368178 W47581 CK023755 BU681625 AA081840 
    F10097 BF962890 AI920873 BF670282 BG171634 AA679239 BE906371 BG168232 
    BE873739 CA418727 BP362399 AA086490 BM453518 T33248 BF575621 AW364525 
    AW368177 AW904452 AA533286 BG701394 BG027307 BE732617 BG565797 BG259591 
    BF672284 BG119018 AA192599 BF790995 AW069724 AL533199 BF664718 D56138 
    BG431372 BE379711 AL519013 BX492545 BG527948 BG572373 BX508584 BQ269228 
    BX462171 AA780364 AL565037 T34858 AI760768 BG484718 BF693656 BG715173 
    BM763522 BG249013 BE702547 BM757524 N21186 BF033622 W47036 BG896626 
    N66793 AA074728 BF750589 BF670829 CB045206 BF694661 AA196936 CB070370 
    AA226164 AI671568 BF670491 BM968716 AA192566 CB156665 BF154508 R68270 
    BF574822 BF673062 AA243987 BF671585 BE971388 BG119574 BF673925 AI830825 
    BM424058 BE618203 AA096230 AW953958 BU948562 T81016 BF695215 W68781 
    BG939616 R68108 BG250071 BF670459 BF213451 AA158636 AW904449 BF672048 
    AA193274 AW904837 T56049 AJ708077 AL579554 BF671275 BF671326 T94677 
    CB131618 AW468515 BG502524 AW889819 BQ271479 BU153077 AA046206 AA193133 
    BG426667 BF576234 BF671796 BE702640 BU071016 BG122783 R62718 BE828318 
    BF671617 AA705930 BQ956339 BF671804 BG114469 AW898290 T65741 BF687772 
    BG939346 AA210750 BF691960 BG252025 BM559774 AF077050 AV749519 BF670636 
    BE271693 AA364756 AW889887 BE699380 AA196311 BF154509 AA092565 BF672453 
    AW238898 AW023069 AA860291 AV706003 BF130487 BF670591 BE763794 BF790838 
    BE566199 BF576075 BF574550 BF670423 BF214932 CB106312 BQ026250 AW889886 
    AV727456 T51677 BF673070 T89081 BQ305855 AA890714 AW020472 BF575245 
    BF438444 H86166 BF671415 BF670790 BE739746 BM193947 AV726731 AW020291 
    BF577006 AI569046 BQ690744 BF670926 BF672700 W69372 AU104982 AL120597 
    BM701973 CA843655 BG748728 BE763799 AI828175 AA086341 N90760 AL526343 
    CB155365 N21304 BM504169 BF694481 AA729870 BG169436 AI310147 BU557287 
    BF575471 AW965418 BX497982 N66444 BM751836 BF671990 AA333196 BM661674 
    BQ306117 R63674 AA503885 BF694559 BE564826 D52691 BX355661 AA167638 
    BF732331 BE564325 BF692913 BG506323 T74296 BG112486 AI022820 F13676 
    BE763144 BF570597 AI799177 W04793 F00105 BM847202 AV704209 BQ942705 
    R41535 BF577028 AW162220 BE866495 BM452395 BG716722 BQ064666 BE936253 
    AW853833 BQ653048 BM006974 BI553082 BU073029 D61090 D56615 BU543505 
    BQ943814 BF209625 W68688 BE927128 BE276084 BG696493 BF750586 T89097 
    BF576606 AV747236 BI962975 AV705918 BE815643 BF694964 BX352000 BQ312682 
    AW903590 BQ305954 BF576728 BG565189 T34689 BG251908 BF208011 AW148462 
    BF693398 BQ710673 BE765329 H43749 BI667702 BM477061 AI419103 BF693401 
    BF574980 BF671114 BE936256 BE568532 BG181155 BI601268 AA167645 AA046212 
    BG537479 BF693258 BF575971 BE699411 BF694370 AW364528 BG112192 BE960981 
    BX452734 BF692821 BF337119 BQ305789 BG427424 BQ306009 AW602732 BF694585 
    BG715601 BF576923 AA095336 BU932723 BU737479 BU169573 BF245381 BM808522 
    AA076201 BQ306498 BF672859 BE866564 BG535989 C16441 BF968889 AW894288 
    BQ305787 BF130582 BF693691 BF947404 BF789957 BU179657 BF575210 BE967564 
    BF031142 BQ306496 BG290850 BG620263 AW268665 BG107460 CB956908 AA180777 
    BF790889 BE699375 AW007478 R78153 BF694869 F37719 R68156 BU146814 
    AA018184 BF978685 BF790734 BF853994 BG750794 BF126405 N56339 BE568846 
    BG779489 BU159470 BQ305850 BF575370 BM912569 BG427373 AA374525 BQ897293 
    BF574724 T71657 BF340304 BQ305845 BF245036 BF749150 W48742 BI598524 
    BX426505 CB109555 AA173844 BQ312115 AA912471 BF693087 BF671762 BM562184 
    AA122208 BQ338261 BG546823 AW952444 BG427896 T94336 N24589 BF671250 
    AV741928 AA055955 BF031510 BX421662 BF693272 H24741 BQ306098 BF877790 
    BF694374 AA074192 H96142 BQ305989 BG477689 N23613 BF576176 T94690 
    BF577181 R54217 CB999040 BE937602 BE738965 BU950008 BQ306120 BF674000 
    BE080807 BE007854 BE702567 R70590 AL519012 BF791087 BQ306018 BE878316 
    AI125763 BE301417 BF789989 BG750920 BQ305991 CA867795 AA192565 BF692987 
    BE738856 BF126139 AV744811 BF575253 BG938827 BQ307250 BG426807 BG252460 
    BM917262 CB106678 BF576056 AW821806 AA131123 AI091717 BF576128 R96380 
    BF670649 CD518427 BQ305965 CB958303 AA252742 BQ305815 BM555265 N31239 
    BF247561 BG335711 AA167765 BG253629 BQ306103 AA249483 BQ305977 BQ305959 
    BF574531 R70605 BQ305966 BI600556 T71810 BF570751 BG419703 BF734642 
    BM811041 BF952838 N66631 AW020481 AW769788 BQ437937 BF671115 BE738986 
    BF081925 AW904777 BF692911 T54675 BF947407 H26582 BF574983 R51821 
    BQ305936 BF208829 BQ690567 BM352482 AW021375 BG114654 BF699457 W19258 
    BE620217 BF693339 AA729509 BG426803 BE183308 AA074467 BE878382 BG111847 
    BF789901 AI016068 BG425264 N77358 BG830985 BG697044 AA179675 BF671309 
    AW999913 BF695292 BQ070754 T81226 BX425693 BF694889 BF790642 BG285440 
    BG492550 BI598065 CB216045 BF790651 H77815 BE878445 BQ305962 BF853455 
    H24742 BM504391 BF693360 BG470542 BE259158 R57784 BQ365871 BU963350 
    BF029400 AW869194 BF791266 AA074698 BF854815 BQ318283 BE172028 AW798234 
    BQ306123 BE183143 CF994031 BF672274 BF084251 BF692868 R18550 BU608214 
    BG395929 AW602720 BQ929066 AI370548 BF576643 BE874623 BE000272 BF667857 
    BQ691804 AI906771 BG338686 BI010843 BQ305941 BE769577 CB955703 BX417670 
    CK000170 CB999216 BE874628 AV712157 BQ277751 BM560071 BG271724 AA213809 
    BQ225231 BF127502 AI745516 BE000268 BF030081 BM915400 BE080952 BE173148 
    BG113256 BE843286 BG106936 BF951041 BG426322 H77859 C14200 BM012637 
    BE568759 W69373 BG009006 BX452747 AA180908 CD356979 AI222638 AI873081 
    CB963179 BG260832 BF575764 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for RTN4 (see all 18)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d ^ 16 ^
    SP1:        -     -     -     -     -     -     -     -     -     -                 -     -     -                       -           -     -                     
    SP2:                          -     -     -     -     -     -     -                 -     -     -                       -           -     -                     
    SP3:                                      -     -     -     -     -                 -     -     -                       -           -     -                     
    SP4:                                                  -     -     -                 -     -     -                       -           -     -                     
    SP5:                                                        -     -                 -     -     -                       -           -     -                     

    ExUns: 17a · 17b · 17c · 17d
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for RTN4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RTN4 expression in normal human tissues (normalized intensities)      RTN4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGCCACA
    RTN4 Expression
    About this image


    RTN4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 26 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             colon ; peripheral nerve/ganglion   
             spinal/ganglion/dorsal root ganglion   
     
     Colon (Gastrointestinal Tract)
             colon ; peripheral nerve/ganglion   
     
     Testis (Reproductive System)
             testis ; cells in seminiferus ducts   

    See RTN4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RTN4

    SOURCE GeneReport for Unigene cluster: Hs.637850

    UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3
    Tissue specificity: Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal
    muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and
    adipocytes. Isoform 4 is testis-specific

        SABiosciences Expression via Pathway-Focused PCR Arrays including RTN4: 
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              Apoptosis 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RTN4 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rtn41 , 5 reticulon 41, 5 83.97(n)1
    78.32(a)1
      11 (16.79 cM)5
    685851  NM_194054.31  NP_918943.11 
     296929475 
    chicken
    (Gallus gallus)
    Aves RTN41 reticulon 4 65.24(n)
    54.37(a)
      378790  XM_003640893.1  XP_003640941.1 
    lizard
    (Anolis carolinensis)
    Reptilia RTN46
    Uncharacterized protein
    47(a)
    1 ↔ 1
    1(263834474-263901082)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684892 hypothetical protein MGC68489 78.12(n)    BC059960.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.247182 Transcribed sequence with weak similarity to protein more 74.33(n)    57038777 


    ENSEMBL Gene Tree for RTN4 (if available)
    TreeFam Gene Tree for RTN4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RTN4 gene
    RTN32  RTN12  RTN22  
    6 SIMAP similar genes for RTN4 using alignment to 10 protein entries:     RTN4_HUMAN (see all proteins):
    NOGOC    Nbla10545    Nbla00271    RTN3    RTN1    RTN2

    RTN4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2140 SNPs in RTN4 are shown (see all 2140)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359044
    A colorectal cancer sample4--see VAR_0359042 L V mis40--------
    rs1505009551,2
    C--55065245(+) CATGTC/TTGCCT 5 -- ds50010--------
    rs774080681,2
    C,F--55065324(+) CGATTA/GATGAT 5 -- ds50011Minor allele frequency- G:0.09WA 118
    rs787088271,2
    C,F--55065441(+) CTGCAC/GTGTAT 5 -- ds50011Minor allele frequency- G:0.01NA 120
    rs8871,2
    C,F,O,A,H--55065457(-) TTAACT/CCACAT 5 -- ds500135Minor allele frequency- C:0.23MN EA NA NS WA CSA 5199
    rs800983851,2
    C,F--55065479(+) ATGAAT/ATTATT 5 -- ds50011Minor allele frequency- A:0.06WA 118
    rs1910984871,2
    --55065501(+) AAACAC/TATCAC 5 -- ds50010--------
    rs38390541,2
    C--55065560(-) AACAA-/AAGTCAA 5 -- ds50010--------
    rs1832858611,2
    --55065573(+) CCACAA/GTAAAC 5 -- ds50010--------
    rs1388756101,2
    C--55065575(+) ACAGT-/AAAC  
            
    AAACA
    5 -- ds50010--------

    HapMap Linkage Disequilibrium report for RTN4 (55199325 - 55339757 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RTN4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2474783CNV Deletion19546169
    esv2517082CNV Deletion19546169
    esv2720078CNV Deletion23290073
    esv267485CNV Insertion20981092
    nsv834069CNV Loss17160897
    nsv874155CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604475    OMIM disorders: --

    20/32 diseases for RTN4 (see all 32):    About MalaCards
    pathological gambling    ventricular septal defect    cerebral artery occlusion    inclusion body myositis
    myositis    cerebrovascular accident    amyotrophic lateral sclerosis    lateral sclerosis
    cervical squamous cell carcinoma    oligodendroglioma    temporal lobe epilepsy    adult t-cell leukemia
    multiple sclerosis    schizophrenia    brain disease    dilated cardiomyopathy
    aortic aneurysm    bipolar disorder    t-cell leukemia    down syndrome

    3 diseases from the University of Copenhagen DISEASES database for RTN4:
    Amyotrophic lateral sclerosis     Multiple sclerosis     Cerebrovascular accident

    RTN4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/12 Novoseek inferred disease relationships for RTN4 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amyotrophic lateral sclerosis 60.8 15 15786457 (3), 18419791 (2), 12270696 (1), 19889996 (1) (see all 9)
    epilepsy temporal lobe 33.9 4 15619232 (1), 15245492 (1), 16772867 (1), 17439704 (1)
    neurodegenerative diseases 32.4 1 14644040 (1)
    schizophrenia 24.9 28 12425946 (5), 15234466 (4), 17022955 (3), 14741411 (2) (see all 8)
    scar 24 3 11597097 (1), 16646157 (1), 15566408 (1)
    multiple sclerosis 20.1 7 14644040 (2), 18495952 (2), 20437585 (1), 17356385 (1) (see all 5)
    small cell lung cancer 17.9 1 11494121 (1)
    tumors 5.29 6 17592524 (2), 12510146 (1), 11891768 (1), 18685489 (1)
    cancer 5.21 5 12510146 (2), 11494121 (2), 15781961 (1)
    neurological disorders 3.72 2 14644040 (2)

    Genetic Association Database (GAD): RTN4
    Human Genome Epidemiology (HuGE) Navigator: RTN4 (10 documents)

    Export disorders for RTN4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RTN4 gene, integrated from 9 sources (see all 218):
    (articles sorted by number of sources associating them with RTN4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. (PubMed id 10667797)1, 2, 3, 9 GrandPre T.... Strittmatter S.M. (2000)
    2. Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping. (PubMed id 10773680)1, 2, 3 Yang J.... Zhao S.-Y. (2000)
    3. Genomic structure and functional characterisation of the promoters of human and mouse nogo/rtn4. (PubMed id 12488097)1, 2, 9 Oertle T.... Schwab M.E. (2003)
    4. No association between the genetic polymorphisms within RTN4 and schizophrenia in the Chinese population. (PubMed id 15234466)1, 4, 9 Chen W....He L. (2004)
    5. Nogo CAA 3'UTR Insertion polymorphism is not associated with Schizophrenia nor with bipolar disorder. (PubMed id 15820318)1, 4, 9 Gregorio S.P....Dias-Neto E. (2005)
    6. Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration. (PubMed id 11891768)1, 2, 9 Ng C.E.L. and Tang B.L. (2002)
    7. Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. (PubMed id 16835300)1, 2, 9 Miao R.Q.... Sessa W.C. (2006)
    8. CAA insertion polymorphism in the 3'UTR of Nogo gene on 2p14 is not associated with schizophrenia. (PubMed id 15661375)1, 4, 9 Xiong L....Joober R. (2005)
    9. Nogo 3'-untranslated region CAA insertion: failure to replicate association with schizophrenia and demonstration of marked population difference in frequency of the insertion. (PubMed id 14741411)1, 4, 9 Covault J....Kranzler H. (2004)
    10. The association between dilated cardiomyopathy and RTN4 3'UTR insertion/deletion polymorphisms. (PubMed id 18948092)1, 4, 9 Zhou B....Zhang L. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57142 HGNC: 14085 AceView: RTN4 Ensembl:ENSG00000115310 euGenes: HUgn57142
    ECgene: RTN4 H-InvDB: RTN4

    (According to HUGE)
    About This Section
    HUGE: KIAA0886

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RTN4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RTN4 Genetics and Cytogenetics in Oncology and Haematology
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=R&genename=RTN4+%40+NOGO
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt069.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RTN4 gene:
    Search GeneIP for patents involving RTN4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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