RTN4 Gene

Aliases
for RTN4 gene

Previous GC identifers: GC02M055237 GC02M055386 GC02M055173 GC02M055110 GC02M054934

Summaries
for RTN4 gene

Genomic Views
for RTN4 gene

RefSeq DNA sequence:

NC_000002.11  NC_018913.1  NT_022184.15  

SwitchGear Promoter luciferase reporter plasmids (see all 10): RTN4 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RTN4

RTN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M055199:  view genomic region     (about GC identifiers)

Proteins
for RTN4 gene

2 PDB 3D structures from and Proteopedia for RTN4:

2G31 (3D)        2JV5 (3D)    

Explore the universe of human proteins at neXtProt for RTN4: NX_Q9NQC3

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for RTN4 (Nogo-A)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): RTN4 OriGene Protein Over-expression Lysate (see all 5): RTN4 OriGene Custom Protein Services for RTN4
	GenScript Custom Purified and Recombinant Proteins Services for RTN4
	Novus Biologicals RTN4 Proteins Novus Biologicals RTN4 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RTN4

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of RTN4
	R&D Systems Antibodies for RTN4 (Nogo-A, Nogo-B, Nogo-C)
	OriGene Antibodies (see all 2): RTN4 OriGene Custom Antibody Services for RTN4
	GenScript Custom Superior Antibodies Services for RTN4
	Novus Biologicals RTN4 Antibodies
	Search for Antibodies for RTN4 at Abcam
	Uscn Antibodies for RTN4
	ThermoFisher Antibodies for RTN4

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RTN4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RTN4

Protein Domains /
Families
for RTN4 gene

ProtoNet protein and cluster: Q9NQC3

Function
for RTN4 gene

miRNA Products:		miRTarBase miRNAs that target RTN4: hsa-mir-16 (MIRT001421), hsa-mir-21 (MIRT000167)
		OriGene 3'-UTR Clone (see all 5): RTN4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RTN4
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RTN4 (see all 19):
		hsa-miR-4318 hsa-miR-15a hsa-miR-503 hsa-miR-3692 hsa-miR-424 hsa-miR-195 hsa-miR-497* hsa-miR-15b
		SwitchGear 3'UTR luciferase reporter plasmid: RTN4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RTN4 (see all 7) OriGene shRNA RFP: RTN4 OriGene siRNA: RTN4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RTN4

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for RTN4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RTN4 (see all 12) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RTN4 (see all 5) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): RTN4 (NM_020532)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RTN4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTN4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RTN4
		Search LifeMap BioReagents cell lines for RTN4

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 8 alleles) (MGI details for Rtn4)

Pathways & Interactions
for RTN4 gene

	Super-pathway	contained gene-specific pathways
1	Axonal growth inhibition (RHOA activation)	Axonal growth inhibition (RHOA activation) 1.00 p75NTR regulates axonogenesis 0.90
2	Development MAG-dependent inhibition of neurite outgrowth	Development MAG-dependent inhibition of neurite outgrowth 1.00 Development_MAG-dependent inhibition of neurite outgrowth 0.87
3	NgR-p75(NTR)-Mediated Signaling	NgR-p75(NTR)-Mediated Signaling 1.00
4	p75(NTR)-mediated signaling	p75(NTR)-mediated signaling 1.00
5	Cell death signalling via NRAGE, NRIF and NADE	p75 NTR receptor-mediated signalling 0.73

1 EMD Millipore Pathway for RTN4

Development MAG-dependent inhibition of neurite outgrowth

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RTN4

NgR-p75(NTR)-Mediated Signaling

1 GeneGo (Thomson Reuters) Pathway for RTN4

Development MAG-dependent inhibition of neurite outgrowth

1 BioSystems Pathway for RTN4

p75(NTR)-mediated signaling

5        Reactome Pathways for RTN4

	Axonal growth inhibition (RHOA activation)
	Signal Transduction
	p75NTR regulates axonogenesis
	Signalling by NGF
	p75 NTR receptor-mediated signalling

Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28):    About this table

Drugs & Compounds
for RTN4 gene

Transcripts
for RTN4 gene

Expression
for RTN4 gene

RTN4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATGCCACA

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	EyeRetina			Eye
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RTN4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RTN4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RTN4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTN4

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4

Orthologs
for RTN4 gene

Paralogs
for RTN4 gene

Paralogs for RTN4 gene

RTN3²  RTN1²  RTN2²  

6 SIMAP similar genes for RTN4 using alignment to 10 protein entries:     RTN4_HUMAN (see all proteins):

NOGOC    Nbla10545    Nbla00271    RTN3    RTN1    RTN2

RTN4 for paralogs           About GeneDecksing

Genomic Variants
for RTN4 gene

10/1829 NCBI SNPs in RTN4 are shown (see all 1829)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1505009551,2		--	55198856(+)	CATGTC/TTGCCT	6	--	ut31 ds5001		0	--	--	--	--
rs774080681,2	F,	--	55198935(+)	CGATTA/GATGAT	6	--	ds5001 ut31		1		WA	118
rs787088271,2		--	55199052(+)	CTGCAC/GTGTAT	6	--	ut31 ds5001		1		NA	120
rs8871,2	C,F,O,A,H,	--	55199068(-)	TTAACT/CCACAT	6	--	ds5001 ut31		35		MN EA NA NS WA CSA	5199
rs800983851,2	F,	--	55199090(+)	ATGAAT/ATTATT	6	--	ut31 ds5001		1		WA	118
rs1910984871,2		--	55199112(+)	AAACAC/TATCAC	6	--	ut31 ds5001		0	--	--	--	--
rs38390541,2	C	--	55199171(-)	AACAA-/AAGTCAA	6	--	ds5001		0	--	--	--	--
rs589239601,2	C,	--	55199171(+)	TTGAC-/TTTTGTT	6	--	ds5001		0	--	--	--	--
rs1832858611,2		--	55199184(+)	CCACAA/GTAAAC	6	--	ds5001		0	--	--	--	--
rs1388756101,2		--	55199186(+)	ACAGT-/AAAC           AAACA	6	--	ds5001		0	--	--	--	--

HapMap Linkage Disequilibrium report for RTN4 (55199325 - 55339757 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RTN4
     2 CNVs: 97862 97861

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RTN4

DNA2.0 Custom Variant and Variant Library Synthesis for RTN4

Disorders / Diseases
for RTN4 gene

20/33 diseases for RTN4

10/12 Novoseek disease relationships for RTN4 gene (see all 12)    About this table

Publications
for RTN4 gene

PubMed articles for RTN4 gene, integrated from 9 sources (see all 210) (see top 10): (articles sorted by number of sources associating them with RTN4)

Utopia: connect your pdf to the dynamic world of online information

1. Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. (PubMed id 10667797)^{1, 2, 3, 9} GrandPre T.... Strittmatter S.M. (2000)
2. Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping. (PubMed id 10773680)^{1, 2, 3} Yang J.... Zhao S.-Y. (2000)
3. Genomic structure and functional characterisation of the promoters of human and mouse nogo/rtn4. (PubMed id 12488097)^{1, 2, 9} Oertle T.... Schwab M.E. (2003)
4. No association between the genetic polymorphisms within RTN4 and schizophrenia in the Chinese population. (PubMed id 15234466)^{1, 4, 9} Chen W....He L. (2004)
5. Nogo CAA 3'UTR Insertion polymorphism is not associated with Schizophrenia nor with bipolar disorder. (PubMed id 15820318)^{1, 4, 9} Gregorio S.P....Dias-Neto E. (2005)
6. Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration. (PubMed id 11891768)^{1, 2, 9} Ng C.E.L. and Tang B.L. (2002)
7. Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. (PubMed id 16835300)^{1, 2, 9} Miao R.Q.... Sessa W.C. (2006)
8. CAA insertion polymorphism in the 3'UTR of Nogo gene on 2p14 is not associated with schizophrenia. (PubMed id 15661375)^{1, 4, 9} Xiong L....Joober R. (2005)
9. Nogo 3'-untranslated region CAA insertion: failure to replicate association with schizophrenia and demonstration of marked population difference in frequency of the insertion. (PubMed id 14741411)^{1, 4, 9} Covault J....Kranzler H. (2004)
10. Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein. (PubMed id 16965550)^{1, 2, 9} Murayama K.S.... Araki W. (2006)
11. Gender-specific association of insertion/deletion polymorphisms in the nogo gene and chronic schizophrenia. (PubMed id 15953657)^{1, 4, 9} Tan E.C....Teo Y.Y. (2005)
12. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. (PubMed id 11201742)^{1, 2, 9} Fournier A.E.... Strittmatter S.M. (2001)
13. A class of dynamin-like GTPases involved in the generation of the tubular ER network. (PubMed id 19665976)^{1, 2} Hu J.... Blackstone C. (2009)
14. Mapping of interaction domains mediating binding between BACE1 and RTN/Nogo proteins. (PubMed id 16979658)^{1, 2} He W.... Yan R. (2006)
15. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
16. Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation. (PubMed id 15286784)^{1, 2} He W.... Yan R. (2004)
17. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)^{1, 2} Wan D....Gu J. (2004)
18. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
19. Pro-apoptotic ASY/Nogo-B protein associates with ASYIP. (PubMed id 12811824)^{1, 2} Qi B.... Yutsudo M. (2003)
20. Expression of a novel reticulon-like gene in human testis. (PubMed id 11866689)^{1, 2} Zhou Z.M.... Zhou K.Y. (2002)
21. Inhibitor of neurite outgrowth in humans. (PubMed id 10667780)^{1, 2} Prinjha R.... Walsh F.S. (2000)
22. A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity. (PubMed id 11126360)^{1, 2} Tagami S.... Tsujimoto Y. (2000)
23. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)^{1, 2} Zhang Q.-H.... Chen Z. (2000)
24. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)^{1, 2} Nagase T....Ohara O. (1998)
25. NOGO mRNA expression in adult and fetal human and rat nervous tissue and in weight drop injury. (PubMed id 11358445)^{1, 9} Josephson A....Spenger C. (2001)
26. Muscle Nogo-A expression is a prognostic marker in lower motor neuron syndromes. (PubMed id 17455292)^{1, 9} Pradat P.F....Meininger V. (2007)
27. Negative correlation of Nogo-A with the malignancy of oligodendroglial tumor. (PubMed id 17592524)^{1, 9} Xiong N.X....He Z.Q. (2007)
28. Increased expression of Nogo-A in hippocampal neurons of patients with temporal lobe epilepsy. (PubMed id 15245492)^{1, 9} Bandtlow C.E....Sperk G. (2004)
29. Biochemical characterization of the recombinant human Nogo-A ectodomain. (PubMed id 17437522)^{1, 9} Zander H....Skerra A. (2007)
30. Increased expression of Noga-A in ALS muscle biopsies is not unique for this disease. (PubMed id 17626519)^{1, 9} Wojcik S....Askanas V. (2006)
31. [Functional interaction of the C-terminal of Nogo protein with connexin 26 and the expression of Nogo's mRNA in the murine inner ear] (PubMed id 17029193)^{1, 9} Xiao Z.A....Pan Q. (2006)
32. Nogo A, B and C expression in schizophrenia, depression and bipolar frontal cortex, and correlation of Nogo expression with CAA/TATC polymorphism in 3'-UTR. (PubMed id 17022955)^{1, 9} Novak G. and Tallerico T. (2006)
33. Expression pattern of NOGO and NgR genes during human development. (PubMed id 15749087)^{1, 9} Al Halabiah H....Simonneau M. (2005)
34. Schizophrenia and Nogo: elevated mRNA in cortex, and high prevalence of a homozygous CAA insert. (PubMed id 12425946)^{1, 9} Novak G....Tallerico T. (2002)
35. Identification of Nogo as a novel indicator of heart failure. (PubMed id 17971502)^{1, 9} Bullard T.A....Blaxall B.C. (2008)
36. NOGO is increased and binds to BACE1 in sporadic inclusion-body myositis and in A beta PP-overexpressing cultured human muscle fibers. (PubMed id 17764014)^{1, 9} Wojcik S....Askanas V. (2007)
37. Nogo-A expression in the human hippocampus in normal aging and in Alzheimer disease. (PubMed id 16772867)^{1, 9} Gil V....del Rio J.A. (2006)
38. Soluble Nogo-A in CSF is not a useful biomarker for multiple sclerosis. (PubMed id 18495952)^{1, 9} Lindsey J.W....Hatfield L.M. (2008)
39. Nogo provides a molecular marker for diagnosis of amyotrophic lateral sclerosis. (PubMed id 12270696)^{1, 9} Dupuis L....Loeffler J.P. (2002)
40. Identification and structural mechanism for a novel interaction between a ubiquitin ligase WWP1 and Nogo-A, a key inhibitor for central nervous system regeneration. (PubMed id 19035836)^{1, 9} Qin H....Song J. (2008)
41. Nogo-a expression in glial CNS tumors: a tool to differentiate between oligodendrogliomas and other gliomas? (PubMed id 18685489)^{1, 9} Kuhlmann T....Bruck W. (2008)
42. Multi-functional gene ASY/Nogo/RTN-X/RTN4: apoptosis, tumor suppression, and inhibition of neuronal regeneration. (PubMed id 12510146)^{1, 9} Watari A. and Yutsudo M. (2003)
43. Protein microarray analysis identifies cyclic nucleot ide phosphodiesterase as an interactor of Nogo-A. (PubMed id 19508346)^{1, 9} Sumiyoshi K....Satoh J. (2010)
44. Reticulon-4A (Nogo-A) redistributes protein disulfide isomerase to protect mice from SOD1-dependent amyotrophic lateral sclerosis. (PubMed id 19889996)^{1, 9} Yang Y.S....Strittmatter S.M. (2009)
45. The N-terminal domain of Nogo-A inhibits cell adhesion and axonal outgrowth by an integrin-specific mechanism. (PubMed id 18234903)^{1, 9} Hu F. and Strittmatter S.M. (2008)
46. The association between dilated cardiomyopathy and RTN4 3'UTR insertion/deletion polymorphisms. (PubMed id 18948092)^{1, 9} Zhou B....Zhang L. (2009)
47. Human Nogo-C overexpression induces HEK293 cell apoptosis via a mechanism that involves JNK-c-Jun pathway. (PubMed id 16905119)^{1, 9} Chen Y....Zhang X. (2006)
48. The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI. (PubMed id 12692556)^{1, 9} Yamashita T. and Tohyama M. (2003)
49. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. (PubMed id 12089450)^{1, 9} Liu B.P.... Strittmatter S.M. (2002)
50. Global landscape of HIV-human protein complexes. (PubMed id 22190034)¹ Jager S....Krogan N.J. (2012)
51. RNT4 3'-UTR insertion/deletion polymorphisms are not a ssociated with atrial septal defect in Chinese Han population: a brief communica tion. (PubMed id 22313113)¹ Li H....Rao L. (2012)
52. A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
53. Genetic variation in RTN4 3'-UTR and susceptibility to cervical squamous cell carcinoma. (PubMed id 22320844)¹ Shi S....Zhang L. (2012)
54. Nogo-A: a useful marker for the diagnosis of oligodend roglioma and for identifying 1p19q codeletion. (PubMed id 21835431)¹ Marucci G....Foschini M.P. (2012)
55. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
56. The role of Nogo and the mitochondria-endoplasmic ret iculum unit in pulmonary hypertension. (PubMed id 21697531)¹ Sutendra G....Michelakis E.D. (2011)
57. Nogo-A expression in oligodendroglial tumors. (PubMed id 20487307)¹ Jung T.Y....Lee M.C. (2011)
58. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)¹ Lee O.H....Songyang Z. (2011)
59. A multi-domain fragment of Nogo-A protein is a potent inhibitor of cortical axon regeneration via Nogo receptor 1. (PubMed id 21454605)¹ Huebner E.A....Strittmatter S.M. (2011)
60. [Significance of Nogo-A expression of atrophic muscle fibers in diagnosis of amyotrophic lateral sclerosis]. (PubMed id 21503119)¹ Sun A.P....Fan D.S. (2011)
61. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
62. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
63. The age- and amyloid-I^-related increases in Nogo B co ntribute to microglial activation. (PubMed id 21111015)¹ Murphy K.J....Lynch M.A. (2011)
64. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
65. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)¹ Emanuele M.J....Elledge S.J. (2011)
66. Nogo-B regulates migration and contraction of airway smooth muscle cells by decreasing ARPC 2/3 and increasing MYL-9 expression. (PubMed id 21251247)¹ Xu W....Li Q. (2011)
67. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
68. Endothelial reticulon-4B (Nogo-B) regulates ICAM-1-me diated leukocyte transmigration and acute inflammation. (PubMed id 21183689)¹ Di Lorenzo A....Sessa W.C. (2011)
69. Nogo receptor 3, a paralog of Nogo-66 receptor 1 (NgR1 ), may function as a NgR1 co-receptor for Nogo-66. (PubMed id 22133682)¹ Zhang L....Zhang J. (2011)
70. Analysis of RTN4 3'UTR insertion/deletion polymorphis ms in ventricular septal defect in a Chinese Han population. (PubMed id 21166502)¹ Chen Y....Rao L. (2011)
71. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
72. Nogo-B mediates HeLa cell adhesion and motility throu gh binding of Fibulin-5. (PubMed id 20599731)¹ Zhou S....Qi Y. (2010)
73. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
74. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
75. Epithelial reticulon 4B (Nogo-B) is an endogenous reg ulator of Th2-driven lung inflammation. (PubMed id 20975041)¹ Wright P.L....Sessa W.C. (2010)
76. Dendritic spine alterations in neocortical pyramidal neurons following postnatal neuronal Nogo-A knockdown. (PubMed id 20938157)¹ Pradhan A.D....Kartje G.L. (2010)
77. RTN3 and RTN4: Candidate modulators in vascular cell apoptosis and atherosclerosis. (PubMed id 20717916)¹ Chen Y....Xiang R. (2010)
78. Overcoming amino-Nogo-induced inhibition of cell spre ading and neurite outgrowth by 12-O-tetradecanoylphorbol-13-acetate-type tumor promoters. (PubMed id 20018888)¹ Deng K....Walsh F.S. (2010)
79. Identification and regulation of reticulon 4B (Nogo-B ) in renal tubular epithelial cells. (PubMed id 20971739)¹ Marin E.P....Sessa W.C. (2010)
80. Atherosclerotic progression attenuates the expression of Nogo-B in autopsied coronary artery: pathology and virtual histology intrav ascular ultrasound analysis. (PubMed id 19654939)¹ Lee W.S....Ryu W.S. (2009)
81. Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PubMed id 19054571)¹ GregA^rio S.P....Dias-Neto E. (2009)
82. Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. (PubMed id 19165527)¹ Martins-de-Souza D....Turck C.W. (2009)
83. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)² Oppermann F.S.... Daub H. (2009)
84. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)
85. New mutations of Nogo-C in hepatocellular carcinoma. (PubMed id 18080785)¹ Chen Y.... Zhuang L. (2009)
86. Common body mass index-associated variants confer ris k of extreme obesity. (PubMed id 19553259)¹ Cotsapas C....Daly M.J. (2009)
87. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)² Choudhary C.... Mann M. (2009)
88. Phosphorylation of Nogo receptors suppresses Nogo sig naling, allowing neurite regeneration. (PubMed id 19336839)¹ Takei Y. (2009)
89. Reassessment of corticospinal tract regeneration in N ogo-deficient mice. (PubMed id 19587271)¹ Lee J.K....Zheng B. (2009)
90. The two-hydrophobic domain tertiary structure of reti culon proteins is critical for modulation of beta-secretase BACE1. (PubMed id 19405102)¹ Kume H....Araki W. (2009)
91. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)¹ Meierhofer D.... Kaiser P. (2008)
92. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)² Daub H.... Mann M. (2008)
93. Reshaping of the endoplasmic reticulum limits the rat e for nuclear envelope formation. (PubMed id 18779370)¹ Anderson D.J. and Hetzer M.W. (2008)
94. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
95. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. (PubMed id 18583979)¹ Allen N.C....Bertram L. (2008)
96. Soluble Nogo-A, an inhibitor of axonal regeneration, as a biomarker for multiple sclerosis. (PubMed id 17242333)¹ Jurewicz A....Selmaj K. (2007)
97. Regulation of Nogo-B expression in the lesion of aortic aneurysms. (PubMed id 17645629)¹ Pan J.W....Rui Y.C. (2007)
98. Roles of glial p75NTR in axonal regeneration. (PubMed id 17335080)¹ Zhou X.F. and Li H.Y. (2007)
99. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)¹ Wu C....Li S.S. (2007)
100. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)¹ Ewing R.M.... Figeys D. (2007)
101. Nogo in the injured spinal cord. (PubMed id 16629624)¹ Schweigreiter R. and Bandtlow C.E. (2006)
102. Down-regulation of ASY/Nogo transcription associated with progression of adult T-cell leukemia/lymphoma. (PubMed id 16646068)¹ Shimakage M....Yutsudo M. (2006)
103. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)² Sjoeblom T.... Velculescu V.E. (2006)
104. The LIFEdb database in 2006. (PubMed id 16381901)¹ Mehrle A....Wiemann S. (2006)
105. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. (PubMed id 15694321)¹ Park J.B....He Z. (2005)
106. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (2005)
107. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
108. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
109. Nogo-B is a new physiological substrate for MAPKAP-K2. (PubMed id 16095439)¹ Rousseau S....Cohen P. (2005)
110. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
111. Reticulon 4 in chondrocytic cells: barosensitivity and intracellular localization. (PubMed id 15147731)¹ Sironen R.K....Lammi M.J. (2004)
112. Phosphoproteomic analysis of the developing mouse brain. (PubMed id 15345747)¹ Ballif B.A.... Gygi S.P. (2004)
113. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)¹ Wiemann S....Poustka A. (2004)
114. A new role for Nogo as a regulator of vascular remodeling. (PubMed id 15034570)¹ Acevedo L....Sessa W.C. (2004)
115. Nogo-A at CNS paranodes is a ligand of Caspr: possible regulation of K(+) channel localization. (PubMed id 14592966)¹ Nie D.Y....Xiao Z.C. (2003)
116. Do cancer cells die because of Nogo-B? (PubMed id 12618765)¹ Oertle T....Schwab M.E. (2003)
117. Myelin-associated inhibitors of axonal regeneration i n the adult mammalian CNS. (PubMed id 12951563)¹ Filbin M.T. (2003)
118. A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein. (PubMed id 12426574)¹ Wong S.T....Poo M.M. (2002)
119. Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP). (PubMed id 12067236)¹ Hu W.-H....Bethea J.R. (2002)
120. Nogo-66 receptor antagonist peptide promotes axonal regeneration. (PubMed id 12037567)¹ GrandPre T.... Strittmatter S.M. (2002)
121. Nogo-A expression in mature oligodendrocytes of rat spinal cord in association with specific molecules. (PubMed id 12377379)¹ Taketomi M....Ide C. (2002)
122. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
123. Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. (PubMed id 10667796)¹ Chen M.S....Schwab M.E. (2000)
124. DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)¹ Hartley J.L....Brasch M.A. (2000)
125. Molecular analysis of Nogo expression in the hippocampus during development and following lesion and seizure. (PubMed id 12692091)⁹ Meier S....Savaskan N.E. (2003)
126. The Nogo receptor, its ligands and axonal regeneration in the spinal cord; a review. (PubMed id 12815233)⁹ Hunt D....Anderson P.N. (2002)
127. Hippocampal Nogo-A and neo-Timm's staining in amygdala kindling rats. (PubMed id 17439704)⁹ Takeda Y....Kobayashi H. (2007)
128. Nogo and Nogo-66 receptor in human and chick: implications for development and regeneration. (PubMed id 15305291)⁹ O'Neill P....Ferretti P. (2004)
129. Nogo signaling and non-physical injury-induced nervous system pathology. (PubMed id 15619232)⁹ Teng F.Y. and Tang B.L. (2005)
130. Soluble Nogo receptor down-regulates expression of ne uronal Nogo-A to enhance axonal regeneration. (PubMed id 19901030)⁹ Peng X....Mata M. (2010)
131. Nogo-A and Nogo-66 receptor in amyotrophic lateral sclerosis. (PubMed id 18419791)⁹ Teng F.Y. and Tang B.L. (2008)
132. Nogo, a star protein in reticulon family. (PubMed id 17704847)⁹ Wang M....Lu Y.P. (2006)
133. Cytokines and neurotrophic factors fail to affect Nogo-A mRNA expression in differentiated human neurones: implications for inflammation-related axonal regeneration in the central nervous system. (PubMed id 11972796)⁹ Satoh J.I. and Kuroda Y. (2002)
134. The N- and C-termini of the human Nogo molecules are intrinsically unstructured: bioinformatics, CD, NMR characterization, and functional implications. (PubMed id 17397058)⁹ Li M. and Song J. (2007)
135. Silencing Nogo-A promotes functional recovery in demy elinating disease. (PubMed id 20437585)⁹ Yang Y....Lovett-Racke A.E. (2010)
136. Molecular regulation of Nogo-A in neural cells: Novel insights into structure and function. (PubMed id 20171301)⁹ Bongiorno D. and Petratos S. (2010)
137. Changes of Nogo-A and receptor NgR in the lumbar spinal cord of ALS model mice. (PubMed id 19243684)⁹ Miyazaki K....Abe K. (2009)
138. Effect of Nogo-A gene inhibition on dopamine release in PC12 cells. (PubMed id 19112410)⁹ Xiong N.X....Zhang F.C. (2008)
139. Nogo: a molecular determinant of axonal growth and regeneration. (PubMed id 11597097)⁹ Grandpre T. and Strittmatter S.M. (2001)
140. Oligodendrocyte precursor cells differentially expressing Nogo-A but not MAG are more permissive to neurite outgrowth than mature oligodendrocytes. (PubMed id 19236864)⁹ Ma Z....Xu X.M. (2009)
141. Characterization of myelin ligand complexes with neuronal Nogo-66 receptor family members. (PubMed id 17189258)⁹ Lauren J....Strittmatter S.M. (2007)
142. Nogo-A is a reliable oligodendroglial marker in adult human and mouse CNS and in demyelinated lesions. (PubMed id 17356385)⁹ Kuhlmann T....Bruck W. (2007)
143. No go for brain tumors? (PubMed id 15781961)⁹ Teng F.Y. and Tang B.L. (2005)
144. Structural characterization of the human Nogo-A functional domains. Solution structure of Nogo-40, a Nogo-66 receptor antagonist enhancing injured spinal cord regeneration. (PubMed id 15317586)⁹ Li M....Song J. (2004)
145. New insights on neuronal alterations in jimpy mutant brain. (PubMed id 15139292)⁹ Harsan L....Ghandour M.S. (2004)
146. Serum and cerebrospinal fluid antibodies to Nogo-A in patients with multiple sclerosis and acute neurological disorders. (PubMed id 14644040)⁹ Reindl M....Bandtlow C.E. (2003)
147. Nogo-A and myelin-associated glycoprotein mediate neurite growth inhibition by antagonistic regulation of RhoA and Rac1. (PubMed id 12451136)⁹ Niederost B....Bandtlow C.E. (2002)
148. Cell autonomous function of Nogo and reticulons: The emerging story at the endoplasmic reticulum. (PubMed id 18330888)⁹ Teng F.Y. and Tang B.L. (2008)
149. Targeting the Nogo-A signalling pathway to promote recovery following acute CNS injury. (PubMed id 17692015)⁹ Walmsley A.R. and Mir A.K. (2007)
150. Knocking-down of Nogo-A gene expression in PC12 cell line by plasmid-based RNAi. (PubMed id 17828504)⁹ Xiong N....Yao D. (2007)
151. Reticulon proteins: emerging players in neurodegenerative diseases. (PubMed id 16505974)⁹ Yan R....Zhou X. (2006)
152. The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model. (PubMed id 17039253)⁹ Jokic N....Loeffler J.P. (2006)
153. Expression pattern of NOGO-A protein in the human ner vous system. (PubMed id 15616791)⁹ Buss A....Brook G.A. (2005)
154. Truncated soluble Nogo receptor binds Nogo-66 and blocks inhibition of axon growth by myelin. (PubMed id 12388594)⁹ Fournier A.E....Strittmatter S.M. (2002)
155. Nogo-A expressed in Schwann cells impairs axonal rege neration after peripheral nerve injury. (PubMed id 12379801)⁹ Pot C....Schwab M.E. (2002)
156. Genomic organization of the human NSP gene, prototype of a novel gene family encoding reticulons. (PubMed id 8833145)⁹ Roebroek A.J.M.... Van de Ven W.J.M. (1996)
157. Pincher-generated Nogo-A endosomes mediate growth con e collapse and retrograde signaling. (PubMed id 20083601)⁹ Joset A....Schwab M.E. (2010)
158. Bone marrow stromal cells stimulate neurite outgrowth over neural proteoglycans (CSPG), myelin associated glycoprotein and Nogo-A. (PubMed id 17234155)⁹ Wright K.T....Johnson W.E. (2007)
159. Neuronal responses to myelin are mediated by rho kina se. (PubMed id 16441511)⁹ Alabed Y.Z....Fournier A.E. (2006)
160. Nogo goes in the pure water: solution structure of Nogo-60 and design of the structured and buffer-soluble Nogo-54 for enhancing CNS regeneration. (PubMed id 16877707)⁹ Li M....Song J. (2006)
161. Nogo-A interacts with the Nogo-66 receptor through multiple sites to create an isoform-selective subnanomolar agonist. (PubMed id 15930377)⁹ Hu F....Strittmatter S.M. (2005)
162. Nogo expression in muscle correlates with amyotrophic lateral sclerosis severity. (PubMed id 15786457)⁹ Jokic N....Meininger V. (2005)
163. Inhibition of Nogo: a key strategy to increase regeneration, plasticity and functional recovery of the lesioned central nervous system. (PubMed id 16338758)⁹ Buchli A.D. and Schwab M.E. (2005)
164. Promotion of axon regeneration by myelin-associated glycoprotein and Nogo through divergent signals downstream of Gi/G. (PubMed id 15282288)⁹ Hasegawa Y....Yamashita T. (2004)
165. Olfactory ensheathing cell phenotype following implantation in the lesioned spinal cord. (PubMed id 14618270)⁹ Woodhall E....Chuah M.I. (2003)
166. Regeneration in the central nervous system. (PubMed id 12543264)⁹ Bandtlow C.E. (2003)
167. Link of a new type of apoptosis-inducing gene ASY/Nogo-B to human cancer. (PubMed id 11494121)⁹ Li Q....Yutsudo M. (2001)
168. Carbamazepine protects against megencephaly and abnormal expression of BDNF and Nogo signaling components in the mceph/mceph mouse. (PubMed id 16990009)⁹ Lavebratt C....Schalling M. (2006)
169. Expression of neurodevelopmental markers by cultured porcine neural precursor cells. (PubMed id 16100001)⁹ Schwartz P.H....Klassen H. (2005)
170. Identification of a functional epitope of the Nogo receptor by a combinatorial approach using ribosome display. (PubMed id 16061255)⁹ Schimmele B. and Pluckthun A. (2005)
171. Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. (PubMed id 12839991)⁹ Barton W.A.... Nikolov D.B. (2003)
172. Nogo (Reticulon 4) expression in innervated and denervated mouse skeletal muscle. (PubMed id 12691732)⁹ Magnusson C....Tagerud S. (2003)
173. Nogo on the go. (PubMed id 12408839)⁹ McKerracher L. and Winton M.J. (2002)
174. Nogo-receptor gene activity: cellular localization and developmental regulation of mRNA in mice and humans. (PubMed id 12378589)⁹ Josephson A....Spenger C. (2002)
175. Neuroendocrine-specific protein C, a marker of neuronal differentiation, is reduced in brain of patients with Down syndrome and Alzheimer's disease. (PubMed id 11006125)⁹ Kim S.H....Lubec G. (2000)
176. Receptors for myelin inhibitors: Structures and thera peutic opportunities. (PubMed id 19619659)⁹ Cao Z....Walsh F.S. (2010)
177. Nogo-A expresses on neural stem cell surface. (PubMed id 20374087)⁹ Hou T....Xiao C. (2010)
178. NgR acts as an inhibitor to axonal regeneration in adults. (PubMed id 17981689)⁹ Zhang S....Qin X. (2008)
179. Regional-specific regulation of BDNF and trkB correlates with nigral dopaminergic cell sprouting following unilateral nigrostriatal axotomy. (PubMed id 18338800)⁹ Garcia Navia J.T....Venero J.L. (2008)
180. The therapeutic effects of Rho-ROCK inhibitors on CNS disorders. (PubMed id 18827856)⁹ Kubo T....Yamashita T. (2008)
181. Nogo-A inhibition induces recovery from neglect in ra ts. (PubMed id 17963852)⁹ Brenneman M.M....Schwab M.E. (2008)
182. Rho-ROCK inhibitors for the treatment of CNS injury. (PubMed id 18221230)⁹ Kubo T. and Yamashita T. (2007)
183. TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions. (PubMed id 17239012)⁹ Satoh J....Konno H. (2007)
184. The Nogo-66 receptor NgR1 is required only for the acute growth cone-collapsing but not the chronic growth-inhibitory actions of myelin inhibitors. (PubMed id 17611264)⁹ Chivatakarn O....Giger R.J. (2007)
185. Expression of Nogo-A in human muscle fibers is not specific for amyotrophic lateral sclerosis. (PubMed id 17894379)⁹ Askanas V....Engel W.K. (2007)
186. Rho-ROCK inhibitors as emerging strategies to promote nerve regeneration. (PubMed id 17692017)⁹ Kubo T....Yamashita T. (2007)
187. Nogo Receptor 1 (RTN4R) as a candidate gene for schizophrenia: analysis using human and mouse genetic approaches. (PubMed id 18043741)⁹ Hsu R....Gogos J.A. (2007)
188. Pathophysiological mechanisms for actions of the neurotrophins. (PubMed id 17107602)⁹ Twiss J.L....Schanen N.C. (2006)
189. Myelin-associated glycoprotein inhibits microtubule assembly by a Rho-kinase-dependent mechanism. (PubMed id 16595691)⁹ Mimura F....Yamashita T. (2006)
190. Polyamine and aminoguanidine treatments to promote structural and functional recovery in the adult mammalian brain after injury: a brief literature review and preliminary data about their combined administration. (PubMed id 16646157)⁹ Schimchowitsch S. and Cassel J.C. (2006)
191. Growth-associated gene and protein expression in the region of axonal sprouting in the aged brain after stroke. (PubMed id 16782355)⁹ Li S. and Carmichael S.T. (2006)
192. MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth. (PubMed id 15953414)⁹ Domeniconi M....Filbin M.T. (2005)
193. Amyotrophic lateral sclerosis: new developments in diagnostic markers. (PubMed id 16909023)⁹ Dengler R....Grosskreutz J. (2005)
194. Nogo-A and nogo receptor expression in demyelinating lesions of multiple sclerosis. (PubMed id 15751227)⁹ Satoh J....Yamamura T. (2005)
195. Zinc metalloproteinase-mediated cleavage of the human Nogo-66 receptor. (PubMed id 15331667)⁹ Walmsley A.R....Frentzel S. (2004)
196. Oligodendrocyte myelin glycoprotein (OMgp): evolution, structure and function. (PubMed id 15145622)⁹ Vourc'h P. and Andres C. (2004)
197. [Inhibitory proteins against axon regeneration in the central nervous system] (PubMed id 15727207)⁹ Hu J.G....Xu X.M. (2004)

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