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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RTN4 Gene

protein-coding   GIFtS: 68
GCID: GC02M055199

Reticulon 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Reticulon 41 2     RTN4-B12
NOGO2 3 5     RTN4-B22
Neurite Outgrowth Inhibitor2 3     RTN4-C2
Neuroendocrine-Specific Protein C Homolog2 3     foocen2
NSP2 3     Human NogoA2
ASY2     My043 Protein2
NI220/2502     Neurite Growth Inhibitor 2202
NOGO-A2     Reticulon 52
NOGOC2     reticulon-42
NSP-CL2     Foocen3
Nbla002712     KIAA08863
Nbla105452     RTN-x3
Nogo-B2     Reticulon-53
Nogo-C2     Neuroendocrine-Specific Protein3
RTN-X2     Nogo Protein3
RTN4-A2     

External Ids:    HGNC: 140851   Entrez Gene: 571422   Ensembl: ENSG000001153107   OMIM: 6044755   UniProtKB: Q9NQC33   

Export aliases for RTN4 gene to outside databases

Previous GC identifers: GC02M055237 GC02M055386 GC02M055173 GC02M055110 GC02M054934


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RTN4 Gene:
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic
reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The
product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the
central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from
differential splicing and differential promoter usage and encoding different isoforms have been identified.
(provided by RefSeq, Jul 2008)

GeneCards Summary for RTN4 Gene: 
RTN4 (reticulon 4) is a protein-coding gene. Diseases associated with RTN4 include pathological gambling, and ventricular septal defect, and among its related super-pathways are p75NTR regulates axonogenesis and Development MAG-dependent inhibition of neurite outgrowth. GO annotations related to this gene include protein binding. An important paralog of this gene is RTN3.

UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3
Function: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion
and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension
in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction
of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing
receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is
likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum,
after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein
processing

Gene Wiki entry for RTN4 (Reticulon 4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RTN4 gene promoter:
         POU2F1   POU2F1a   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 10): RTN4 promoter sequence
   Search SABiosciences Chromatin IP Primers for RTN4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RTN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.3   Ensembl cytogenetic band:  2p16.1   HGNC cytogenetic band: 2p14-p13

RTN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTN4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M055199:  view genomic region     (about GC identifiers)

Start:
55,199,325 bp from pter      End:
55,339,757 bp from pter
Size:
140,433 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3 (See protein sequence)
Recommended Name: Reticulon-4  
Size: 1192 amino acids; 129931 Da
Subunit: Binds to RTN4R. Interacts with Bcl-xl and Bcl-2. Isoform 2 binds to NGBR and RTN3. Isoform 2 and isoform
3 interact with BACE1 and BACE2. Interacts with RTN4IP1. Interacts with ATL1
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Anchored to the membrane
of the endoplasmic reticulum through 2 putative transmembrane domains
Sequence caution: Sequence=AAD39920.1; Type=Frameshift; Positions=1149, 1156; Sequence=AAG43160.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAG43160.1; Type=Frameshift; Positions=684, 700;
Sequence=BAA74909.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for RTN4:
2G31 (3D)        2JV5 (3D)    
Secondary accessions: O94962 Q7L7Q5 Q7L7Q6 Q7L7Q8 Q8IUA4 Q96B16 Q9BXG5 Q9H212 Q9H3I3 Q9UQ42
Q9Y293 Q9Y2Y7 Q9Y5U6
Alternative splicing: 6 isoforms:  Q9NQC3-1   Q9NQC3-2   Q9NQC3-3   Q9NQC3-4   Q9NQC3-5   Q9NQC3-6   

Explore the universe of human proteins at neXtProt for RTN4: NX_Q9NQC3

Explore proteomics data for RTN4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NQC3

  • RTN4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RTN4 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_008939.1  NP_065393.1  NP_722550.1  NP_997403.1  NP_997404.1  

    ENSEMBL proteins: 
     ENSP00000378107   ENSP00000384471   ENSP00000349944   ENSP00000337838   ENSP00000322147  
     ENSP00000350365   ENSP00000378109   ENSP00000385650   ENSP00000397808   ENSP00000411628  
     ENSP00000384825   ENSP00000346465  
    Reactome Protein details: Q9NQC3
    Human Recombinant Protein Products for RTN4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for RTN4 (Nogo-A)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for RTN4
    OriGene Protein Over-expression Lysate for RTN4
    OriGene MassSpec for RTN4 
    OriGene Custom Protein Services for RTN4
    GenScript Custom Purified and Recombinant Proteins Services for RTN4
    Novus Biologicals RTN4 Proteins
    Novus Biologicals RTN4 Lysates
    Sino Biological Recombinant Protein for RTN4
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RTN4 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IDA11126360
    GO:0005783endoplasmic reticulum NAS11126360
    GO:0005886plasma membrane TAS--
    GO:0030176integral to endoplasmic reticulum membrane IDA10667797
    GO:0042995cell projection IEA--

    RTN4 for ontologies           About GeneDecksing



    RTN4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RTN4
    R&D Systems Antibodies for RTN4 (Nogo-A, Nogo-B, Nogo-C)
    OriGene Antibodies for RTN4
    OriGene Custom Antibody Services for RTN4
    GenScript Custom Superior Antibodies Services for RTN4
    Novus Biologicals RTN4 Antibodies
    Abcam antibodies for RTN4
    Cloud-Clone Corp. Antibodies for RTN4 
    ThermoFisher Antibodies for RTN4
    LSBio Antibodies in human, mouse, rat for RTN4 

    Assay Products for RTN4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RTN4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RTN4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RTN4 
    Cloud-Clone Corp. CLIAs for RTN4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003388 Reticulon

    Graphical View of Domain Structure for InterPro Entry Q9NQC3

    ProtoNet protein and cluster: Q9NQC3

    1 Blocks protein domain: IPB003388 Reticulon

    UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3
    Domain: Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane
    domains, known as Nogo-66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the
    spreading of neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity)
    Similarity: Contains 1 reticulon domain


    RTN4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RTN4_HUMAN, Q9NQC3
    Function: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion
    and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension
    in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction
    of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing
    receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is
    likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum,
    after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein
    processing

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11126360
         
    RTN4 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Rtn4):
     cellular  mortality/aging  nervous system  normal 

    RTN4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RTN4: Rtn4tm1Schw Rtn4tm2.1Matl Rtn4tm2Matl

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RTN4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RTN4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RTN4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RTN4 

    miRNA
    Products:
        
    miRTarBase miRNAs that target RTN4:
    hsa-mir-16 (MIRT001421), hsa-mir-21 (MIRT000167)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RTN4
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RTN4 (see all 19):
    hsa-miR-4318 hsa-miR-15a hsa-miR-503 hsa-miR-3692 hsa-miR-424 hsa-miR-195 hsa-miR-497* hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidRTN4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of RTN4

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RTN4 (see all 32)
    OriGene ORF clones in mouse, rat for RTN4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): RTN4 (NM_020532)
    Sino Biological Human cDNA Clone for RTN4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RTN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTN4
    Sirion Biotech Customized lentivirus for stable overexpression of RTN4 
                         Customized lentivirus expression plasmids for stable overexpression of RTN4 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for RTN4
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RTN4 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Axonal growth inhibition (RHOA activation)
    Axonal growth inhibition (RHOA activation)0.90
    p75NTR regulates axonogenesis0.90
    2Development MAG-dependent inhibition of neurite outgrowth
    Development MAG-dependent inhibition of neurite outgrowth0.87
    3Cell death signalling via NRAGE, NRIF and NADE
    p75 NTR receptor-mediated signalling0.73
    4Signaling by FGFR
    Signalling by NGF0.71
    5Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RTN4
        Development MAG-dependent inhibition of neurite outgrowth

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RTN4
        NgR-p75(NTR)-Mediated Signaling

    1 GeneGo (Thomson Reuters) Pathway for RTN4
        Development MAG-dependent inhibition of neurite outgrowth

    2 BioSystems Pathways for RTN4
        Spinal Cord Injury
    p75(NTR)-mediated signaling


    5        Reactome Pathways for RTN4
        Axonal growth inhibition (RHOA activation)
    Signal Transduction
    p75NTR regulates axonogenesis
    Signalling by NGF
    p75 NTR receptor-mediated signalling



    RTN4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RTN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/67 Interacting proteins for RTN4 (Q9NQC31, 2, 3 ENSP000003378384) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000236693P044402, 3, ENSP000004141964MINT-8258153 I2D: score=2 STRING: ENSP00000414196
    ENSG00000237710P044402, 3, ENSP000003892884MINT-8258153 I2D: score=2 STRING: ENSP00000389288
    ENSG00000215048P044402, 3MINT-8258153 I2D: score=2 
    ENSG00000226826P044402, 3MINT-8258153 I2D: score=2 
    ENSG00000230763P044402, 3MINT-8258153 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006915apoptotic process NAS11126360
    GO:0007399nervous system development ----
    GO:0007413axonal fasciculation ISS--
    GO:0021801cerebral cortex radial glia guided migration ISS--

    RTN4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RTN4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RTN4

    1 Novoseek inferred chemical compound relationship for RTN4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ddvp 58 1 17029193 (1)

    Search CenterWatch for drugs/clinical trials and news about RTN4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RTN4 gene (5 alternative transcripts): 
    NM_007008.2  NM_020532.4  NM_153828.2  NM_207520.1  NM_207521.1  

    Unigene Cluster for RTN4:

    Reticulon 4
    Hs.637850  [show with all ESTs]
    Unigene Representative Sequence: NM_020532
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394609(uc002ryc.3) ENST00000405240 ENST00000357376(uc002ryd.3)
    ENST00000337526(uc002rye.3) ENST00000317610(uc002ryg.3) ENST00000357732(uc002ryf.3)
    ENST00000394611 ENST00000404909 ENST00000486085 ENST00000491592 ENST00000485749
    ENST00000438462 ENST00000427710 ENST00000461004 ENST00000402434 ENST00000354474


    miRNA
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    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RTN4 (see all 19):
    hsa-miR-4318 hsa-miR-15a hsa-miR-503 hsa-miR-3692 hsa-miR-424 hsa-miR-195 hsa-miR-497* hsa-miR-15b
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    Inhib. RNA
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    Additional mRNA sequence: 

    AB015639.1 AB020693.1 AB040462.1 AB040463.1 AB073351.1 AB073359.1 AF063601.1 AF077050.1 
    AF087901.1 AF125103.1 AF132047.1 AF132048.1 AF148537.1 AF148538.1 AF177332.1 AF320999.1 
    AF333336.1 AJ251383.1 AJ251384.1 AJ251385.1 AK075039.1 AK098385.1 AK129806.1 AK130812.1 
    AK172726.1 AK302741.1 AY102276.1 AY102277.1 AY102278.1 AY102279.1 AY123245.1 AY123246.1 
    AY123247.1 AY123248.1 AY123249.1 AY123250.1 BC001035.2 BC007109.1 BC010737.1 BC012619.1 
    BC014366.1 BC016165.1 BC026788.1 BC068991.1 BC071848.1 BC150182.1 BC152425.1 BC152555.1 
    DQ778739.1 

    24/70 DOTS entries (see all 70):

    DT.87018236  DT.92057768  DT.91855184  DT.100039375  DT.97862663  DT.95148397  DT.100889622  DT.97776594 
    DT.100039374  DT.100889645  DT.100039372  DT.121021010  DT.100889631  DT.420660  DT.100889638  DT.100889649 
    DT.100889641  DT.100889621  DT.121021012  DT.408266  DT.95128616  DT.95329023  DT.100889636  DT.102838873 

    24/1507 AceView cDNA sequences (see all 1507):

    AA746210 AA370616 CB164794 AA192937 W19399 BF448757 BQ638521 AA331600 
    BF591729 CB162885 AJ251384 W73282 CB108617 BU729639 AU104978 AY123247 
    BU952509 W21129 CB133824 AI217084 BM709363 AA058672 W95807 AL533461 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for RTN4 (see all 18)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d ^ 16 ^
    SP1:        -     -     -     -     -     -     -     -     -     -                 -     -     -                       -           -     -                     
    SP2:                          -     -     -     -     -     -     -                 -     -     -                       -           -     -                     
    SP3:                                      -     -     -     -     -                 -     -     -                       -           -     -                     
    SP4:                                                  -     -     -                 -     -     -                       -           -     -                     
    SP5:                                                        -     -                 -     -     -                       -           -     -                     

    ExUns: 17a · 17b · 17c · 17d
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for RTN4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RTN4 expression in normal human tissues (normalized intensities)      RTN4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGCCACA
    RTN4 Expression
    About this image


    RTN4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 26 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             colon ; peripheral nerve/ganglion   
             spinal/ganglion/dorsal root ganglion   
     
     Colon (Gastrointestinal Tract)
             colon ; peripheral nerve/ganglion   
     
     Testis (Reproductive System)
             testis ; cells in seminiferus ducts   

    See RTN4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RTN4

    SOURCE GeneReport for Unigene cluster: Hs.637850

    UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3
    Tissue specificity: Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal
    muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and
    adipocytes. Isoform 4 is testis-specific

        SABiosciences Expression via Pathway-Focused PCR Arrays including RTN4: 
              Neurogenesis in human mouse rat
              Nephrotoxicity in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RTN4
    OriGene qSTAR qPCR primer pairs in human, mouse for RTN4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RTN4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RTN4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTN4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RTN4 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rtn41 , 5 reticulon 41, 5 83.97(n)1
    78.32(a)1
      11 (16.79 cM)5
    685851  NM_194054.31  NP_918943.11 
     296929475 
    chicken
    (Gallus gallus)
    Aves RTN41 reticulon 4 65.24(n)
    54.37(a)
      378790  XM_003640893.1  XP_003640941.1 
    lizard
    (Anolis carolinensis)
    Reptilia RTN46
    Uncharacterized protein
    47(a)
    1 ↔ 1
    1(263834474-263901082)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684892 hypothetical protein MGC68489 78.12(n)    BC059960.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.247182 Transcribed sequence with weak similarity to protein more 74.33(n)    57038777 


    ENSEMBL Gene Tree for RTN4 (if available)
    TreeFam Gene Tree for RTN4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RTN4 gene
    RTN32  RTN12  RTN22  
    6 SIMAP similar genes for RTN4 using alignment to 10 protein entries:     RTN4_HUMAN (see all proteins):
    NOGOC    Nbla10545    Nbla00271    RTN3    RTN1    RTN2

    RTN4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2140 SNPs in RTN4 are shown (see all 2140)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359044
    A colorectal cancer sample4--see VAR_0359042 L V mis40--------
    rs1505009551,2
    C--55065245(+) CATGTC/TTGCCT 5 -- ds50010--------
    rs774080681,2
    C,F--55065324(+) CGATTA/GATGAT 5 -- ds50011Minor allele frequency- G:0.09WA 118
    rs787088271,2
    C,F--55065441(+) CTGCAC/GTGTAT 5 -- ds50011Minor allele frequency- G:0.01NA 120
    rs8871,2
    C,F,O,A,H--55065457(-) TTAACT/CCACAT 5 -- ds500135Minor allele frequency- C:0.23MN EA NA NS WA CSA 5199
    rs800983851,2
    C,F--55065479(+) ATGAAT/ATTATT 5 -- ds50011Minor allele frequency- A:0.06WA 118
    rs1910984871,2
    --55065501(+) AAACAC/TATCAC 5 -- ds50010--------
    rs38390541,2
    C--55065560(-) AACAA-/AAGTCAA 5 -- ds50010--------
    rs1832858611,2
    --55065573(+) CCACAA/GTAAAC 5 -- ds50010--------
    rs1388756101,2
    C--55065575(+) ACAGT-/AAAC  
            
    AAACA
    5 -- ds50010--------

    HapMap Linkage Disequilibrium report for RTN4 (55199325 - 55339757 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RTN4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2474783CNV Deletion19546169
    esv2517082CNV Deletion19546169
    esv2720078CNV Deletion23290073
    esv267485CNV Insertion20981092
    nsv834069CNV Loss17160897
    nsv874155CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RTN4
    DNA2.0 Custom Variant and Variant Library Synthesis for RTN4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604475    OMIM disorders: --

    20/32 diseases for RTN4 (see all 32):    About MalaCards
    pathological gambling    ventricular septal defect    cerebral artery occlusion    inclusion body myositis
    myositis    cerebrovascular accident    amyotrophic lateral sclerosis    lateral sclerosis
    cervical squamous cell carcinoma    oligodendroglioma    temporal lobe epilepsy    adult t-cell leukemia
    multiple sclerosis    schizophrenia    brain disease    dilated cardiomyopathy
    aortic aneurysm    bipolar disorder    t-cell leukemia    down syndrome

    3 diseases from the University of Copenhagen DISEASES database for RTN4:
    Amyotrophic lateral sclerosis     Multiple sclerosis     Cerebrovascular accident

    RTN4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/12 Novoseek inferred disease relationships for RTN4 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amyotrophic lateral sclerosis 60.8 15 15786457 (3), 18419791 (2), 12270696 (1), 19889996 (1) (see all 9)
    epilepsy temporal lobe 33.9 4 15619232 (1), 15245492 (1), 16772867 (1), 17439704 (1)
    neurodegenerative diseases 32.4 1 14644040 (1)
    schizophrenia 24.9 28 12425946 (5), 15234466 (4), 17022955 (3), 14741411 (2) (see all 8)
    scar 24 3 11597097 (1), 16646157 (1), 15566408 (1)
    multiple sclerosis 20.1 7 14644040 (2), 18495952 (2), 20437585 (1), 17356385 (1) (see all 5)
    small cell lung cancer 17.9 1 11494121 (1)
    tumors 5.29 6 17592524 (2), 12510146 (1), 11891768 (1), 18685489 (1)
    cancer 5.21 5 12510146 (2), 11494121 (2), 15781961 (1)
    neurological disorders 3.72 2 14644040 (2)

    Genetic Association Database (GAD): RTN4
    Human Genome Epidemiology (HuGE) Navigator: RTN4 (10 documents)

    Export disorders for RTN4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RTN4 gene, integrated from 9 sources (see all 218) (see top 10):
    (articles sorted by number of sources associating them with RTN4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. (PubMed id 10667797)1, 2, 3, 9 GrandPre T.... Strittmatter S.M. (2000)
    2. Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping. (PubMed id 10773680)1, 2, 3 Yang J.... Zhao S.-Y. (2000)
    3. Genomic structure and functional characterisation of the promoters of human and mouse nogo/rtn4. (PubMed id 12488097)1, 2, 9 Oertle T.... Schwab M.E. (2003)
    4. No association between the genetic polymorphisms within RTN4 and schizophrenia in the Chinese population. (PubMed id 15234466)1, 4, 9 Chen W....He L. (2004)
    5. Nogo CAA 3'UTR Insertion polymorphism is not associated with Schizophrenia nor with bipolar disorder. (PubMed id 15820318)1, 4, 9 Gregorio S.P....Dias-Neto E. (2005)
    6. Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration. (PubMed id 11891768)1, 2, 9 Ng C.E.L. and Tang B.L. (2002)
    7. Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. (PubMed id 16835300)1, 2, 9 Miao R.Q.... Sessa W.C. (2006)
    8. CAA insertion polymorphism in the 3'UTR of Nogo gene on 2p14 is not associated with schizophrenia. (PubMed id 15661375)1, 4, 9 Xiong L....Joober R. (2005)
    9. Nogo 3'-untranslated region CAA insertion: failure to replicate association with schizophrenia and demonstration of marked population difference in frequency of the insertion. (PubMed id 14741411)1, 4, 9 Covault J....Kranzler H. (2004)
    10. The association between dilated cardiomyopathy and RTN4 3'UTR insertion/deletion polymorphisms. (PubMed id 18948092)1, 4, 9 Zhou B....Zhang L. (2009)
    11. Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein. (PubMed id 16965550)1, 2, 9 Murayama K.S.... Araki W. (2006)
    12. Gender-specific association of insertion/deletion polymorphisms in the nogo gene and chronic schizophrenia. (PubMed id 15953657)1, 4, 9 Tan E.C....Teo Y.Y. (2005)
    13. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. (PubMed id 11201742)1, 2, 9 Fournier A.E.... Strittmatter S.M. (2001)
    14. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    15. Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PubMed id 19054571)1, 4 GregA^rio S.P....Dias-Neto E. (2009)
    16. A class of dynamin-like GTPases involved in the generation of the tubular ER network. (PubMed id 19665976)1, 2 Hu J.... Blackstone C. (2009)
    17. Common body mass index-associated variants confer ris k of extreme obesity. (PubMed id 19553259)1, 4 Cotsapas C....Daly M.J. (2009)
    18. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. (PubMed id 18583979)1, 4 Allen N.C....Bertram L. (2008)
    19. Mapping of interaction domains mediating binding between BACE1 and RTN/Nogo proteins. (PubMed id 16979658)1, 2 He W.... Yan R. (2006)
    20. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    21. Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation. (PubMed id 15286784)1, 2 He W.... Yan R. (2004)
    22. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    23. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    24. Pro-apoptotic ASY/Nogo-B protein associates with ASYIP. (PubMed id 12811824)1, 2 Qi B.... Yutsudo M. (2003)
    25. Expression of a novel reticulon-like gene in human testis. (PubMed id 11866689)1, 2 Zhou Z.M.... Zhou K.Y. (2002)
    26. Inhibitor of neurite outgrowth in humans. (PubMed id 10667780)1, 2 Prinjha R.... Walsh F.S. (2000)
    27. A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity. (PubMed id 11126360)1, 2 Tagami S.... Tsujimoto Y. (2000)
    28. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    29. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T....Ohara O. (1998)
    30. NOGO mRNA expression in adult and fetal human and rat nervous tissue and in weight drop injury. (PubMed id 11358445)1, 9 Josephson A....Spenger C. (2001)
    31. Muscle Nogo-A expression is a prognostic marker in lower motor neuron syndromes. (PubMed id 17455292)1, 9 Pradat P.F....Meininger V. (2007)
    32. Negative correlation of Nogo-A with the malignancy of oligodendroglial tumor. (PubMed id 17592524)1, 9 Xiong N.X....He Z.Q. (2007)
    33. Increased expression of Nogo-A in hippocampal neurons of patients with temporal lobe epilepsy. (PubMed id 15245492)1, 9 Bandtlow C.E....Sperk G. (2004)
    34. Biochemical characterization of the recombinant human Nogo-A ectodomain. (PubMed id 17437522)1, 9 Zander H....Skerra A. (2007)
    35. Increased expression of Noga-A in ALS muscle biopsies is not unique for this disease. (PubMed id 17626519)1, 9 Wojcik S....Askanas V. (2006)
    36. [Functional interaction of the C-terminal of Nogo protein with connexin 26 and the expression of Nogo's mRNA in the murine inner ear] (PubMed id 17029193)1, 9 Xiao Z.A....Pan Q. (2006)
    37. Nogo A, B and C expression in schizophrenia, depression and bipolar frontal cortex, and correlation of Nogo expression with CAA/TATC polymorphism in 3'-UTR. (PubMed id 17022955)1, 9 Novak G. and Tallerico T. (2006)
    38. Expression pattern of NOGO and NgR genes during human development. (PubMed id 15749087)1, 9 Al Halabiah H....Simonneau M. (2005)
    39. Schizophrenia and Nogo: elevated mRNA in cortex, and high prevalence of a homozygous CAA insert. (PubMed id 12425946)1, 9 Novak G....Tallerico T. (2002)
    40. Identification of Nogo as a novel indicator of heart failure. (PubMed id 17971502)1, 9 Bullard T.A....Blaxall B.C. (2008)
    41. NOGO is increased and binds to BACE1 in sporadic inclusion-body myositis and in A beta PP-overexpressing cultured human muscle fibers. (PubMed id 17764014)1, 9 Wojcik S....Askanas V. (2007)
    42. Nogo-A expression in the human hippocampus in normal aging and in Alzheimer disease. (PubMed id 16772867)1, 9 Gil V....del Rio J.A. (2006)
    43. Soluble Nogo-A in CSF is not a useful biomarker for multiple sclerosis. (PubMed id 18495952)1, 9 Lindsey J.W....Hatfield L.M. (2008)
    44. Nogo provides a molecular marker for diagnosis of amyotrophic lateral sclerosis. (PubMed id 12270696)1, 9 Dupuis L....Loeffler J.P. (2002)
    45. Identification and structural mechanism for a novel interaction between a ubiquitin ligase WWP1 and Nogo-A, a key inhibitor for central nervous system regeneration. (PubMed id 19035836)1, 9 Qin H....Song J. (2008)
    46. Nogo-a expression in glial CNS tumors: a tool to differentiate between oligodendrogliomas and other gliomas? (PubMed id 18685489)1, 9 Kuhlmann T....Bruck W. (2008)
    47. Multi-functional gene ASY/Nogo/RTN-X/RTN4: apoptosis, tumor suppression, and inhibition of neuronal regeneration. (PubMed id 12510146)1, 9 Watari A. and Yutsudo M. (2003)
    48. Protein microarray analysis identifies cyclic nucleot ide phosphodiesterase as an interactor of Nogo-A. (PubMed id 19508346)1, 9 Sumiyoshi K....Satoh J. (2010)
    49. Reticulon-4A (Nogo-A) redistributes protein disulfide isomerase to protect mice from SOD1-dependent amyotrophic lateral sclerosis. (PubMed id 19889996)1, 9 Yang Y.S....Strittmatter S.M. (2009)
    50. The N-terminal domain of Nogo-A inhibits cell adhesion and axonal outgrowth by an integrin-specific mechanism. (PubMed id 18234903)1, 9 Hu F. and Strittmatter S.M. (2008)
    51. Human Nogo-C overexpression induces HEK293 cell apoptosis via a mechanism that involves JNK-c-Jun pathway. (PubMed id 16905119)1, 9 Chen Y....Zhang X. (2006)
    52. The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI. (PubMed id 12692556)1, 9 Yamashita T. and Tohyama M. (2003)
    53. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. (PubMed id 12089450)1, 9 Liu B.P.... Strittmatter S.M. (2002)
    54. Identifying protein partners of CLN8, an ER-resident p rotein involved in neuronal ceroid lipofuscinosis. (PubMed id 23142642)1 Passantino R....Guarneri P. (2013)
    55. Absence of Nogo-B (reticulon 4B) facilitates hepatic s tellate cell apoptosis and diminishes hepatic fibrosis in mice. (PubMed id 23313137)1 Tashiro K....Iwakiri Y. (2013)
    56. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    57. Expression of nogo-a is decreased with increasing gest ational age in the human fetal brain. (PubMed id 23146900)1 Haybaeck J....Weis S. (2012)
    58. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    59. RNT4 3'-UTR insertion/deletion polymorphisms are not a ssociated with atrial septal defect in Chinese Han population: a brief communica tion. (PubMed id 22313113)1 Li H....Rao L. (2012)
    60. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    61. Genetic variation in RTN4 3'-UTR and susceptibility to cervical squamous cell carcinoma. (PubMed id 22320844)1 Shi S....Zhang L. (2012)
    62. Nogo-A: a useful marker for the diagnosis of oligodend roglioma and for identifying 1p19q codeletion. (PubMed id 21835431)1 Marucci G....Foschini M.P. (2012)
    63. PKCe promotes oncogenic functions of ATF2 in the nucle us while blocking its apoptotic function at mitochondria. (PubMed id 22304920)1 Lau E....Ronai Z.A. (2012)
    64. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    65. The role of Nogo and the mitochondria-endoplasmic ret iculum unit in pulmonary hypertension. (PubMed id 21697531)1 Sutendra G....Michelakis E.D. (2011)
    66. Nogo-A expression in oligodendroglial tumors. (PubMed id 20487307)1 Jung T.Y....Lee M.C. (2011)
    67. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
    68. A multi-domain fragment of Nogo-A protein is a potent inhibitor of cortical axon regeneration via Nogo receptor 1. (PubMed id 21454605)1 Huebner E.A....Strittmatter S.M. (2011)
    69. [Significance of Nogo-A expression of atrophic muscle fibers in diagnosis of amyotrophic lateral sclerosis]. (PubMed id 21503119)1 Sun A.P....Fan D.S. (2011)
    70. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    71. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    72. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    73. The age- and amyloid-I^-related increases in Nogo B co ntribute to microglial activation. (PubMed id 21111015)1 Murphy K.J....Lynch M.A. (2011)
    74. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    75. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    76. Nogo-B regulates migration and contraction of airway smooth muscle cells by decreasing ARPC 2/3 and increasing MYL-9 expression. (PubMed id 21251247)1 Xu W....Li Q. (2011)
    77. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    78. Endothelial reticulon-4B (Nogo-B) regulates ICAM-1-me diated leukocyte transmigration and acute inflammation. (PubMed id 21183689)1 Di Lorenzo A....Sessa W.C. (2011)
    79. Nogo receptor 3, a paralog of Nogo-66 receptor 1 (NgR1 ), may function as a NgR1 co-receptor for Nogo-66. (PubMed id 22133682)1 Zhang L....Zhang J. (2011)
    80. Analysis of RTN4 3'UTR insertion/deletion polymorphis ms in ventricular septal defect in a Chinese Han population. (PubMed id 21166502)1 Chen Y....Rao L. (2011)
    81. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    82. Nogo-B mediates HeLa cell adhesion and motility throu gh binding of Fibulin-5. (PubMed id 20599731)1 Zhou S....Qi Y. (2010)
    83. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    84. Epithelial reticulon 4B (Nogo-B) is an endogenous reg ulator of Th2-driven lung inflammation. (PubMed id 20975041)1 Wright P.L....Sessa W.C. (2010)
    85. Dendritic spine alterations in neocortical pyramidal neurons following postnatal neuronal Nogo-A knockdown. (PubMed id 20938157)1 Pradhan A.D....Kartje G.L. (2010)
    86. RTN3 and RTN4: Candidate modulators in vascular cell apoptosis and atherosclerosis. (PubMed id 20717916)1 Chen Y....Xiang R. (2010)
    87. Overcoming amino-Nogo-induced inhibition of cell spre ading and neurite outgrowth by 12-O-tetradecanoylphorbol-13-acetate-type tumor promoters. (PubMed id 20018888)1 Deng K....Walsh F.S. (2010)
    88. Identification and regulation of reticulon 4B (Nogo-B ) in renal tubular epithelial cells. (PubMed id 20971739)1 Marin E.P....Sessa W.C. (2010)
    89. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    90. Atherosclerotic progression attenuates the expression of Nogo-B in autopsied coronary artery: pathology and virtual histology intrav ascular ultrasound analysis. (PubMed id 19654939)1 Lee W.S....Ryu W.S. (2009)
    91. Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. (PubMed id 19165527)1 Martins-de-Souza D....Turck C.W. (2009)
    92. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
    93. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    94. New mutations of Nogo-C in hepatocellular carcinoma. (PubMed id 18080785)1 Chen Y.... Zhuang L. (2009)
    95. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
    96. Phosphorylation of Nogo receptors suppresses Nogo sig naling, allowing neurite regeneration. (PubMed id 19336839)1 Takei Y. (2009)
    97. Reassessment of corticospinal tract regeneration in N ogo-deficient mice. (PubMed id 19587271)1 Lee J.K....Zheng B. (2009)
    98. The two-hydrophobic domain tertiary structure of reti culon proteins is critical for modulation of beta-secretase BACE1. (PubMed id 19405102)1 Kume H....Araki W. (2009)
    99. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1 Meierhofer D.... Kaiser P. (2008)
    100. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
    101. Reshaping of the endoplasmic reticulum limits the rat e for nuclear envelope formation. (PubMed id 18779370)1 Anderson D.J. and Hetzer M.W. (2008)
    102. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    103. Soluble Nogo-A, an inhibitor of axonal regeneration, as a biomarker for multiple sclerosis. (PubMed id 17242333)1 Jurewicz A....Selmaj K. (2007)
    104. Regulation of Nogo-B expression in the lesion of aortic aneurysms. (PubMed id 17645629)1 Pan J.W....Rui Y.C. (2007)
    105. Roles of glial p75NTR in axonal regeneration. (PubMed id 17335080)1 Zhou X.F. and Li H.Y. (2007)
    106. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
    107. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)
    108. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
    109. Nogo in the injured spinal cord. (PubMed id 16629624)1 Schweigreiter R. and Bandtlow C.E. (2006)
    110. Down-regulation of ASY/Nogo transcription associated with progression of adult T-cell leukemia/lymphoma. (PubMed id 16646068)1 Shimakage M....Yutsudo M. (2006)
    111. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    112. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    113. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. (PubMed id 15694321)1 Park J.B....He Z. (2005)
    114. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    115. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    116. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    117. Nogo-B is a new physiological substrate for MAPKAP-K2. (PubMed id 16095439)1 Rousseau S....Cohen P. (2005)
    118. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    119. Reticulon 4 in chondrocytic cells: barosensitivity and intracellular localization. (PubMed id 15147731)1 Sironen R.K....Lammi M.J. (2004)
    120. Phosphoproteomic analysis of the developing mouse brain. (PubMed id 15345747)1 Ballif B.A.... Gygi S.P. (2004)
    121. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
    122. A new role for Nogo as a regulator of vascular remodeling. (PubMed id 15034570)1 Acevedo L....Sessa W.C. (2004)
    123. Nogo-A at CNS paranodes is a ligand of Caspr: possible regulation of K(+) channel localization. (PubMed id 14592966)1 Nie D.Y....Xiao Z.C. (2003)
    124. Do cancer cells die because of Nogo-B? (PubMed id 12618765)1 Oertle T....Schwab M.E. (2003)
    125. Myelin-associated inhibitors of axonal regeneration i n the adult mammalian CNS. (PubMed id 12951563)1 Filbin M.T. (2003)
    126. A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein. (PubMed id 12426574)1 Wong S.T....Poo M.M. (2002)
    127. Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP). (PubMed id 12067236)1 Hu W.-H....Bethea J.R. (2002)
    128. Nogo-66 receptor antagonist peptide promotes axonal regeneration. (PubMed id 12037567)1 GrandPre T.... Strittmatter S.M. (2002)
    129. Nogo-A expression in mature oligodendrocytes of rat spinal cord in association with specific molecules. (PubMed id 12377379)1 Taketomi M....Ide C. (2002)
    130. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    131. Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. (PubMed id 10667796)1 Chen M.S....Schwab M.E. (2000)
    132. DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)1 Hartley J.L....Brasch M.A. (2000)
    133. Molecular analysis of Nogo expression in the hippocampus during development and following lesion and seizure. (PubMed id 12692091)9 Meier S....Savaskan N.E. (2003)
    134. The Nogo receptor, its ligands and axonal regeneration in the spinal cord; a review. (PubMed id 12815233)9 Hunt D....Anderson P.N. (2002)
    135. Hippocampal Nogo-A and neo-Timm's staining in amygdala kindling rats. (PubMed id 17439704)9 Takeda Y....Kobayashi H. (2007)
    136. Nogo and Nogo-66 receptor in human and chick: implications for development and regeneration. (PubMed id 15305291)9 O'Neill P....Ferretti P. (2004)
    137. Nogo signaling and non-physical injury-induced nervous system pathology. (PubMed id 15619232)9 Teng F.Y. and Tang B.L. (2005)
    138. Soluble Nogo receptor down-regulates expression of ne uronal Nogo-A to enhance axonal regeneration. (PubMed id 19901030)9 Peng X....Mata M. (2010)
    139. Nogo-A and Nogo-66 receptor in amyotrophic lateral sclerosis. (PubMed id 18419791)9 Teng F.Y. and Tang B.L. (2008)
    140. Nogo, a star protein in reticulon family. (PubMed id 17704847)9 Wang M....Lu Y.P. (2006)
    141. Cytokines and neurotrophic factors fail to affect Nogo-A mRNA expression in differentiated human neurones: implications for inflammation-related axonal regeneration in the central nervous system. (PubMed id 11972796)9 Satoh J.I. and Kuroda Y. (2002)
    142. The N- and C-termini of the human Nogo molecules are intrinsically unstructured: bioinformatics, CD, NMR characterization, and functional implications. (PubMed id 17397058)9 Li M. and Song J. (2007)
    143. Silencing Nogo-A promotes functional recovery in demy elinating disease. (PubMed id 20437585)9 Yang Y....Lovett-Racke A.E. (2010)
    144. Molecular regulation of Nogo-A in neural cells: Novel insights into structure and function. (PubMed id 20171301)9 Bongiorno D. and Petratos S. (2010)
    145. Changes of Nogo-A and receptor NgR in the lumbar spinal cord of ALS model mice. (PubMed id 19243684)9 Miyazaki K....Abe K. (2009)
    146. Effect of Nogo-A gene inhibition on dopamine release in PC12 cells. (PubMed id 19112410)9 Xiong N.X....Zhang F.C. (2008)
    147. Nogo: a molecular determinant of axonal growth and regeneration. (PubMed id 11597097)9 Grandpre T. and Strittmatter S.M. (2001)
    148. Oligodendrocyte precursor cells differentially expressing Nogo-A but not MAG are more permissive to neurite outgrowth than mature oligodendrocytes. (PubMed id 19236864)9 Ma Z....Xu X.M. (2009)
    149. Characterization of myelin ligand complexes with neuronal Nogo-66 receptor family members. (PubMed id 17189258)9 Lauren J....Strittmatter S.M. (2007)
    150. Nogo-A is a reliable oligodendroglial marker in adult human and mouse CNS and in demyelinated lesions. (PubMed id 17356385)9 Kuhlmann T....Bruck W. (2007)
    151. No go for brain tumors? (PubMed id 15781961)9 Teng F.Y. and Tang B.L. (2005)
    152. Structural characterization of the human Nogo-A functional domains. Solution structure of Nogo-40, a Nogo-66 receptor antagonist enhancing injured spinal cord regeneration. (PubMed id 15317586)9 Li M....Song J. (2004)
    153. New insights on neuronal alterations in jimpy mutant brain. (PubMed id 15139292)9 Harsan L....Ghandour M.S. (2004)
    154. Serum and cerebrospinal fluid antibodies to Nogo-A in patients with multiple sclerosis and acute neurological disorders. (PubMed id 14644040)9 Reindl M....Bandtlow C.E. (2003)
    155. Nogo-A and myelin-associated glycoprotein mediate neurite growth inhibition by antagonistic regulation of RhoA and Rac1. (PubMed id 12451136)9 Niederost B....Bandtlow C.E. (2002)
    156. Cell autonomous function of Nogo and reticulons: The emerging story at the endoplasmic reticulum. (PubMed id 18330888)9 Teng F.Y. and Tang B.L. (2008)
    157. Targeting the Nogo-A signalling pathway to promote recovery following acute CNS injury. (PubMed id 17692015)9 Walmsley A.R. and Mir A.K. (2007)
    158. Knocking-down of Nogo-A gene expression in PC12 cell line by plasmid-based RNAi. (PubMed id 17828504)9 Xiong N....Yao D. (2007)
    159. Reticulon proteins: emerging players in neurodegenerative diseases. (PubMed id 16505974)9 Yan R....Zhou X. (2006)
    160. The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model. (PubMed id 17039253)9 Jokic N....Loeffler J.P. (2006)
    161. Expression pattern of NOGO-A protein in the human ner vous system. (PubMed id 15616791)9 Buss A....Brook G.A. (2005)
    162. Truncated soluble Nogo receptor binds Nogo-66 and blocks inhibition of axon growth by myelin. (PubMed id 12388594)9 Fournier A.E....Strittmatter S.M. (2002)
    163. Nogo-A expressed in Schwann cells impairs axonal rege neration after peripheral nerve injury. (PubMed id 12379801)9 Pot C....Schwab M.E. (2002)
    164. Genomic organization of the human NSP gene, prototype of a novel gene family encoding reticulons. (PubMed id 8833145)9 Roebroek A.J.M.... Van de Ven W.J.M. (1996)
    165. Pincher-generated Nogo-A endosomes mediate growth con e collapse and retrograde signaling. (PubMed id 20083601)9 Joset A....Schwab M.E. (2010)
    166. Bone marrow stromal cells stimulate neurite outgrowth over neural proteoglycans (CSPG), myelin associated glycoprotein and Nogo-A. (PubMed id 17234155)9 Wright K.T....Johnson W.E. (2007)
    167. Neuronal responses to myelin are mediated by rho kina se. (PubMed id 16441511)9 Alabed Y.Z....Fournier A.E. (2006)
    168. Nogo goes in the pure water: solution structure of Nogo-60 and design of the structured and buffer-soluble Nogo-54 for enhancing CNS regeneration. (PubMed id 16877707)9 Li M....Song J. (2006)
    169. Nogo-A interacts with the Nogo-66 receptor through multiple sites to create an isoform-selective subnanomolar agonist. (PubMed id 15930377)9 Hu F....Strittmatter S.M. (2005)
    170. Nogo expression in muscle correlates with amyotrophic lateral sclerosis severity. (PubMed id 15786457)9 Jokic N....Meininger V. (2005)
    171. Inhibition of Nogo: a key strategy to increase regeneration, plasticity and functional recovery of the lesioned central nervous system. (PubMed id 16338758)9 Buchli A.D. and Schwab M.E. (2005)
    172. Promotion of axon regeneration by myelin-associated glycoprotein and Nogo through divergent signals downstream of Gi/G. (PubMed id 15282288)9 Hasegawa Y....Yamashita T. (2004)
    173. Olfactory ensheathing cell phenotype following implantation in the lesioned spinal cord. (PubMed id 14618270)9 Woodhall E....Chuah M.I. (2003)
    174. Regeneration in the central nervous system. (PubMed id 12543264)9 Bandtlow C.E. (2003)
    175. Link of a new type of apoptosis-inducing gene ASY/Nogo-B to human cancer. (PubMed id 11494121)9 Li Q....Yutsudo M. (2001)
    176. Carbamazepine protects against megencephaly and abnormal expression of BDNF and Nogo signaling components in the mceph/mceph mouse. (PubMed id 16990009)9 Lavebratt C....Schalling M. (2006)
    177. Expression of neurodevelopmental markers by cultured porcine neural precursor cells. (PubMed id 16100001)9 Schwartz P.H....Klassen H. (2005)
    178. Identification of a functional epitope of the Nogo receptor by a combinatorial approach using ribosome display. (PubMed id 16061255)9 Schimmele B. and Pluckthun A. (2005)
    179. Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. (PubMed id 12839991)9 Barton W.A.... Nikolov D.B. (2003)
    180. Nogo (Reticulon 4) expression in innervated and denervated mouse skeletal muscle. (PubMed id 12691732)9 Magnusson C....Tagerud S. (2003)
    181. Nogo on the go. (PubMed id 12408839)9 McKerracher L. and Winton M.J. (2002)
    182. Nogo-receptor gene activity: cellular localization and developmental regulation of mRNA in mice and humans. (PubMed id 12378589)9 Josephson A....Spenger C. (2002)
    183. Neuroendocrine-specific protein C, a marker of neuronal differentiation, is reduced in brain of patients with Down syndrome and Alzheimer's disease. (PubMed id 11006125)9 Kim S.H....Lubec G. (2000)
    184. Receptors for myelin inhibitors: Structures and thera peutic opportunities. (PubMed id 19619659)9 Cao Z....Walsh F.S. (2010)
    185. Nogo-A expresses on neural stem cell surface. (PubMed id 20374087)9 Hou T....Xiao C. (2010)
    186. NgR acts as an inhibitor to axonal regeneration in adults. (PubMed id 17981689)9 Zhang S....Qin X. (2008)
    187. Regional-specific regulation of BDNF and trkB correlates with nigral dopaminergic cell sprouting following unilateral nigrostriatal axotomy. (PubMed id 18338800)9 Garcia Navia J.T....Venero J.L. (2008)
    188. The therapeutic effects of Rho-ROCK inhibitors on CNS disorders. (PubMed id 18827856)9 Kubo T....Yamashita T. (2008)
    189. Nogo-A inhibition induces recovery from neglect in ra ts. (PubMed id 17963852)9 Brenneman M.M....Schwab M.E. (2008)
    190. Rho-ROCK inhibitors for the treatment of CNS injury. (PubMed id 18221230)9 Kubo T. and Yamashita T. (2007)
    191. TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions. (PubMed id 17239012)9 Satoh J....Konno H. (2007)
    192. The Nogo-66 receptor NgR1 is required only for the acute growth cone-collapsing but not the chronic growth-inhibitory actions of myelin inhibitors. (PubMed id 17611264)9 Chivatakarn O....Giger R.J. (2007)
    193. Expression of Nogo-A in human muscle fibers is not specific for amyotrophic lateral sclerosis. (PubMed id 17894379)9 Askanas V....Engel W.K. (2007)
    194. Rho-ROCK inhibitors as emerging strategies to promote nerve regeneration. (PubMed id 17692017)9 Kubo T....Yamashita T. (2007)
    195. Nogo Receptor 1 (RTN4R) as a candidate gene for schizophrenia: analysis using human and mouse genetic approaches. (PubMed id 18043741)9 Hsu R....Gogos J.A. (2007)
    196. Pathophysiological mechanisms for actions of the neurotrophins. (PubMed id 17107602)9 Twiss J.L....Schanen N.C. (2006)
    197. Myelin-associated glycoprotein inhibits microtubule assembly by a Rho-kinase-dependent mechanism. (PubMed id 16595691)9 Mimura F....Yamashita T. (2006)

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    Entrez Gene: 57142 HGNC: 14085 AceView: RTN4 Ensembl:ENSG00000115310 euGenes: HUgn57142
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