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RTN4 Gene

protein-coding   GIFtS: 68
GCID: GC02M055199

Reticulon 4

  See RTN4-related disease

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Reticulon 41 2     RTN4-B12
NOGO2 3 5     RTN4-B22
Neurite Outgrowth Inhibitor2 3     RTN4-C2
Neuroendocrine-Specific Protein C Homolog2 3     foocen2
NSP2 3     Human NogoA2
ASY2     My043 Protein2
NI220/2502     Neurite Growth Inhibitor 2202
NOGO-A2     Reticulon 52
NOGOC2     reticulon-42
NSP-CL2     Foocen3
Nbla002712     KIAA08863
Nbla105452     RTN-x3
Nogo-B2     Reticulon-53
Nogo-C2     Neuroendocrine-Specific Protein3
RTN-X2     Nogo Protein3

External Ids:    HGNC: 140851   Entrez Gene: 571422   Ensembl: ENSG000001153107   OMIM: 6044755   UniProtKB: Q9NQC33   

Export aliases for RTN4 gene to outside databases

Previous GC identifiers: GC02M055237 GC02M055386 GC02M055173 GC02M055110 GC02M054934

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RTN4 Gene:
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic
reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The
product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the
central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from
differential splicing and differential promoter usage and encoding different isoforms have been identified.
(provided by RefSeq, Jul 2008)

GeneCards Summary for RTN4 Gene:
RTN4 (reticulon 4) is a protein-coding gene. Diseases associated with RTN4 include schizophrenia. An important paralog of this gene is RTN3.

UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3
Function: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion
and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension
in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction
of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing
receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is
likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum,
after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein

Gene Wiki entry for RTN4 (Reticulon 4) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RTN4 gene promoter:
         POU2F1   POU2F1a   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 10): RTN4 promoter sequence
   Search Chromatin IP Primers for RTN4

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RTN4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.3   Ensembl cytogenetic band:  2p16.1   HGNC cytogenetic band: 2p14-p13

RTN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTN4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M055199:  view genomic region     (about GC identifiers)

55,199,325 bp from pter      End:
55,339,757 bp from pter
140,433 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section

UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3 (See protein sequence)
Recommended Name: Reticulon-4  
Size: 1192 amino acids; 129931 Da
Subunit: Binds to RTN4R. Interacts with Bcl-xl and Bcl-2. Isoform 2 binds to NGBR and RTN3. Isoform 2 and isoform
3 interact with BACE1 and BACE2. Interacts with RTN4IP1. Interacts with ATL1
Sequence caution: Sequence=AAD39920.1; Type=Frameshift; Positions=1149, 1156; Sequence=AAG43160.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAG43160.1; Type=Frameshift; Positions=684, 700;
Sequence=BAA74909.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for RTN4:
2G31 (3D)        2JV5 (3D)    
Secondary accessions: O94962 Q7L7Q5 Q7L7Q6 Q7L7Q8 Q8IUA4 Q96B16 Q9BXG5 Q9H212 Q9H3I3 Q9UQ42
Q9Y293 Q9Y2Y7 Q9Y5U6
Alternative splicing: 6 isoforms:  Q9NQC3-1   Q9NQC3-2   Q9NQC3-3   Q9NQC3-4   Q9NQC3-5   Q9NQC3-6   

Explore the universe of human proteins at neXtProt for RTN4: NX_Q9NQC3

Explore proteomics data for RTN4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1090, Lys1104, Lys1171
  • Modification sites at PhosphoSitePlus

  • See RTN4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_008939.1  NP_065393.1  NP_722550.1  NP_997403.1  NP_997404.1  

    ENSEMBL proteins: 
     ENSP00000378107   ENSP00000384471   ENSP00000349944   ENSP00000337838   ENSP00000322147  
     ENSP00000350365   ENSP00000378109   ENSP00000385650   ENSP00000397808   ENSP00000411628  
     ENSP00000384825   ENSP00000346465  
    Reactome Protein details: Q9NQC3

    RTN4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for RTN4 (Nogo-A)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for RTN4
    OriGene Protein Over-expression Lysate for RTN4
    OriGene MassSpec for RTN4
    OriGene Custom Protein Services for RTN4
    GenScript Custom Purified and Recombinant Proteins Services for RTN4
    Novus Biologicals RTN4 Proteins
    Novus Biologicals RTN4 Lysates
    Sino Biological Recombinant Protein for RTN4
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RTN4

    Search eBioscience for Proteins for RTN4 

    antibodies-online proteins for RTN4 (7 products) 

    antibodies-online peptides for RTN4

    Search GeneTex for Proteins for RTN4 

    RTN4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RTN4
    R&D Systems Antibodies for RTN4 (Nogo-A, Nogo-B, Nogo-C)
    OriGene Antibodies for RTN4
    OriGene Custom Antibody Services for RTN4
    Novus Biologicals RTN4 Antibodies
    Abcam antibodies for RTN4
    Cloud-Clone Corp. Antibodies for RTN4
    ThermoFisher Antibodies for RTN4
    antibodies-online antibodies for RTN4 (115 products) 

    GeneTex Antibodies for RTN4:  
                        RTN4 Antibodies

    RTN4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RTN4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RTN4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RTN4
    Cloud-Clone Corp. CLIAs for RTN4
    Search eBioscience for ELISAs for RTN4 
    antibodies-online kits for RTN4 (12 products) 

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    1 InterPro protein domain:
     IPR003388 Reticulon

    Graphical View of Domain Structure for InterPro Entry Q9NQC3

    ProtoNet protein and cluster: Q9NQC3

    1 Blocks protein domain: IPB003388 Reticulon

    UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3
    Domain: Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane
    domains, known as Nogo-66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the
    spreading of neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity)
    Similarity: Contains 1 reticulon domain

    Find genes that share domains with RTN4           About GenesLikeMe

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RTN4_HUMAN, Q9NQC3
    Function: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion
    and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension
    in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction
    of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing
    receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is
    likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum,
    after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11126360
    GO:0044822poly(A) RNA binding IDA--
    Find genes that share ontologies with RTN4           About GenesLikeMe

         4 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Rtn4):
     cellular  mortality/aging  nervous system  normal 

    Find genes that share phenotypes with RTN4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RTN4: Rtn4tm1Schw Rtn4tm2.1Matl Rtn4tm2Matl

       genOway: Develop your customized and physiologically relevant rodent model for RTN4

        Taconic Biosciences Mouse Models for RTN4:  
                        TF1410 - Rtn4

    CRISPR Knockouts: 
       OriGene CRISPR knockouts for RTN4

    miRTarBase miRNAs that target RTN4:
    hsa-mir-320a (MIRT044751), hsa-mir-30c-5p (MIRT047850), hsa-mir-132-3p (MIRT021845), hsa-mir-21-5p (MIRT000167), hsa-mir-183-5p (MIRT024991), hsa-mir-148b-3p (MIRT019491), hsa-mir-33a-5p (MIRT028224), hsa-mir-16-5p (MIRT001421), hsa-mir-34a-5p (MIRT025475), hsa-mir-101-3p (MIRT027341)

    Block miRNA regulation of human, mouse, rat RTN4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RTN4 (see all 19):
    hsa-miR-4318 hsa-miR-15a hsa-miR-503 hsa-miR-3692 hsa-miR-424 hsa-miR-195 hsa-miR-497* hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidRTN4 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for RTN4
    Predesigned siRNA for gene silencing in human, mouse, rat RTN4

    OriGene clones in human, mouse for RTN4 (see all 33)
    OriGene ORF clones in mouse, rat for RTN4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): RTN4 (NM_020532)
    Sino Biological Human cDNA Clone for RTN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTN4

    Cell Line
    GenScript Custom overexpressing Cell Line Services for RTN4
    Browse ESI BIO Cell Lines and PureStem Progenitors for RTN4 
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Subcellular locations from UniProtKB/Swiss-Prot
    RTN4_HUMAN, Q9NQC3: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Anchored to the membrane
    of the endoplasmic reticulum through 2 putative transmembrane domains
    Subcellular locations from COMPARTMENTS: 

    endoplasmic reticulum5
    plasma membrane4

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IDA11126360
    GO:0005783endoplasmic reticulum NAS11126360
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane ----
    GO:0030176integral component of endoplasmic reticulum membrane IDA10667797

    Find genes that share ontologies with RTN4           About GenesLikeMe

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    SuperPaths for RTN4 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    p75NTR regulates axonogenesis0.00
    Axonal growth inhibition (RHOA activation)0.00
    2Signaling by FGFR
    Signalling by NGF0.71
    3Signaling by GPCR
    Signal Transduction0.58
    4Cell adhesion Integrin-mediated cell adhesion and migration
    Development MAG-dependent inhibition of neurite outgrowth0.42
    5Spinal Cord Injury
    Spinal Cord Injury

    Find genes that share SuperPaths with RTN4           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RTN4
        NgR-p75(NTR)-Mediated Signaling

    1 GeneGo (Thomson Reuters) Pathway for RTN4
        Development MAG-dependent inhibition of neurite outgrowth

    2 BioSystems Pathways for RTN4
        Spinal Cord Injury
    p75(NTR)-mediated signaling

    1 Reactome Pathway for RTN4
        Axonal growth inhibition (RHOA activation)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RTN4: 
              Neurogenesis in human mouse rat
              Nephrotoxicity in human mouse rat
              Apoptosis 384HT in human mouse rat


        GeneGlobe Interaction Network for RTN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RTN4 (Q9NQC31, 2, 3 ENSP000003378384) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000236693P044402, 3, ENSP000004141964MINT-8258153 I2D: score=2 STRING: ENSP00000414196
    ENSG00000237710P044402, 3, ENSP000003892884MINT-8258153 I2D: score=2 STRING: ENSP00000389288
    ENSG00000215048P044402, 3MINT-8258153 I2D: score=2 
    ENSG00000226826P044402, 3MINT-8258153 I2D: score=2 
    ENSG00000230763P044402, 3MINT-8258153 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006915apoptotic process NAS11126360
    GO:0007399nervous system development ----
    GO:0007413axonal fasciculation ISS--
    GO:0021801cerebral cortex radial glia guided migration ISS--

    Find genes that share ontologies with RTN4           About GenesLikeMe

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RTN4

    1 Novoseek inferred chemical compound relationship for RTN4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ddvp 58 1 17029193 (1)

    Find genes that share compounds with RTN4           About GenesLikeMe

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    REFSEQ mRNAs for RTN4 gene (6 alternative transcripts): 
    NM_007008.2  NM_020532.4  NM_153828.2  NM_207520.1  NM_207521.1  XM_005264434.2  

    Unigene Cluster for RTN4:

    Reticulon 4
    Hs.637850  [show with all ESTs]
    Unigene Representative Sequence: NM_020532
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394609(uc002ryc.3) ENST00000405240 ENST00000357376(uc002ryd.3)
    ENST00000337526(uc002rye.3) ENST00000317610(uc002ryg.3) ENST00000357732(uc002ryf.3)
    ENST00000394611 ENST00000404909 ENST00000486085 ENST00000491592 ENST00000485749
    ENST00000438462 ENST00000427710 ENST00000461004 ENST00000402434 ENST00000354474

    Block miRNA regulation of human, mouse, rat RTN4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RTN4 (see all 19):
    hsa-miR-4318 hsa-miR-15a hsa-miR-503 hsa-miR-3692 hsa-miR-424 hsa-miR-195 hsa-miR-497* hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidRTN4 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for RTN4
    Predesigned siRNA for gene silencing in human, mouse, rat RTN4
    OriGene clones in human, mouse for RTN4 (see all 33)
    OriGene ORF clones in mouse, rat for RTN4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): RTN4 (NM_020532)
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTN4
    OriGene qPCR primer pairs and template standards for RTN4
    OriGene qSTAR qPCR primer pairs in human, mouse for RTN4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RTN4
      QuantiTect SYBR Green Assays in human, mouse, rat RTN4
      QuantiFast Probe-based Assays in human, mouse, rat RTN4

    Additional mRNA sequence: 

    AB015639.1 AB020693.1 AB040462.1 AB040463.1 AB073351.1 AB073359.1 AF063601.1 AF077050.1 
    AF087901.1 AF125103.1 AF132047.1 AF132048.1 AF148537.1 AF148538.1 AF177332.1 AF320999.1 
    AF333336.1 AJ251383.1 AJ251384.1 AJ251385.1 AK075039.1 AK098385.1 AK129806.1 AK130812.1 
    AK172726.1 AK302741.1 AY102276.1 AY102277.1 AY102278.1 AY102279.1 AY123245.1 AY123246.1 
    AY123247.1 AY123248.1 AY123249.1 AY123250.1 BC001035.2 BC007109.1 BC010737.1 BC012619.1 
    BC014366.1 BC016165.1 BC026788.1 BC068991.1 BC071848.1 BC150182.1 BC152425.1 BC152555.1 

    Selected DOTS entries (see all 70):

    DT.87018236  DT.92057768  DT.91855184  DT.100039375  DT.97862663  DT.95148397  DT.100889622  DT.97776594 
    DT.100039374  DT.100889645  DT.100039372  DT.121021010  DT.100889631  DT.420660  DT.100889638  DT.100889649 
    DT.100889641  DT.100889621  DT.121021012  DT.408266  DT.95128616  DT.95329023  DT.100889636  DT.102838873 

    Selected AceView cDNA sequences (see all 1507):

    BM666337 AU104978 BU684302 AI217084 CB108617 AW673265 AA058672 CN483287 
    CB133824 AA370615 CD723962 AK130812 CB148622 AU104981 BM709363 T34690 
    R96423 AA331600 AI828700 AA307342 BE302112 BU952509 BX439214 N73666 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RTN4 (see all 18)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d ^ 16 ^
    SP1:        -     -     -     -     -     -     -     -     -     -                 -     -     -                       -           -     -                     
    SP2:                          -     -     -     -     -     -     -                 -     -     -                       -           -     -                     
    SP3:                                      -     -     -     -     -                 -     -     -                       -           -     -                     
    SP4:                                                  -     -     -                 -     -     -                       -           -     -                     
    SP5:                                                        -     -                 -     -     -                       -           -     -                     

    ExUns: 17a · 17b · 17c · 17d

    ECgene alternative splicing isoforms for RTN4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RTN4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    RTN4 Expression
    About this image

    RTN4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     Brain (Nervous System)    fully expand to see all 4 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     Eye (Sensory Organs)
     Bone (Muscoskeletal System)
             Bone Marrow
     Colon (Gastrointestinal Tract)
     Uterus (Reproductive System)
    RTN4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RTN4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.637850

    UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3
    Tissue specificity: Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal
    muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and
    adipocytes. Isoform 4 is testis-specific

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RTN4: 
              Neurogenesis in human mouse rat
              Nephrotoxicity in human mouse rat
              Apoptosis 384HT in human mouse rat

    OriGene qPCR primer pairs and template standards for RTN4
    OriGene qSTAR qPCR primer pairs in human, mouse for RTN4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RTN4
    QuantiTect SYBR Green Assays in human, mouse, rat RTN4
    QuantiFast Probe-based Assays in human, mouse, rat RTN4
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RTN4 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Rtn41 , 5 reticulon 41, 5 83.56(n)1
      11 (16.79 cM)5
    685851  NM_194054.31  NP_918943.11 
    (Gallus gallus)
    Aves LOC1017495791 reticulon-4-like 60.49(n)
      101749579  XM_004940171.1  XP_004940228.1 
    (Anolis carolinensis)
    Reptilia RTN46
    reticulon 4
    1 ↔ 1
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684892 hypothetical protein MGC68489 78.12(n)    BC059960.1 
    (Danio rerio)
    Actinopterygii Dr.247182 Transcribed sequence with weak similarity to protein more 74.33(n)    57038777 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rtnl16
    (see all 3)
    (see all 3)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    (Caenorhabditis elegans)
    Secernentea ret-16
    Protein RET-1, isoform c
    1 → many
    V(14829177-14847312) WBGene00004336

    ENSEMBL Gene Tree for RTN4 (if available)
    TreeFam Gene Tree for RTN4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for RTN4 gene
    RTN32  RTN12  RTN22  
    6 SIMAP similar genes for RTN4 using alignment to 10 protein entries:     RTN4_HUMAN (see all proteins):
    NOGOC    Nbla10545    Nbla00271    RTN3    RTN1    RTN2

    Find genes that share paralogs with RTN4           About GenesLikeMe

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    Selected SNPs for RTN4 (see all 2140)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 2 posSequence#AA
    A colorectal cancer sample4--see VAR_0359042 L V mis40--------
    C--55065245(+) CATGTC/TTGCCT 5 -- ds50010--------
    C,F--55065324(+) CGATTA/GATGAT 5 -- ds50011Minor allele frequency- G:0.09WA 118
    C,F--55065441(+) CTGCAC/GTGTAT 5 -- ds50011Minor allele frequency- G:0.01NA 120
    C,F,O,A,H--55065457(-) TTAACT/CCACAT 5 -- ds500135Minor allele frequency- C:0.23MN EA NA NS WA CSA 5199
    C,F--55065479(+) ATGAAT/ATTATT 5 -- ds50011Minor allele frequency- A:0.06WA 118
    --55065501(+) AAACAC/TATCAC 5 -- ds50010--------
    C--55065560(-) AACAA-/AAGTCAA 5 -- ds50010--------
    --55065573(+) CCACAA/GTAAAC 5 -- ds50010--------
    C--55065575(+) ACAGT-/AAAC  
    5 -- ds50010--------

    HapMap Linkage Disequilibrium report for RTN4 (55199325 - 55339757 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RTN4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2474783CNV Deletion19546169
    esv2517082CNV Deletion19546169
    esv2720078CNV Deletion23290073
    esv267485CNV Insertion20981092
    nsv834069CNV Loss17160897
    nsv874155CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RTN4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 604475    OMIM disorders: --

    1 disease for RTN4:    
    About MalaCards

    3 inferred disease relationships from the University of Copenhagen DISEASES database for RTN4:
    Amyotrophic lateral sclerosis     Multiple sclerosis     Cerebrovascular accident

    Find genes that share disorders with RTN4           About GenesLikeMe

    Selected Novoseek inferred disease relationships for RTN4 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amyotrophic lateral sclerosis 60.8 15 15786457 (3), 18419791 (2), 12270696 (1), 19889996 (1) (see all 9)
    epilepsy temporal lobe 33.9 4 15619232 (1), 15245492 (1), 16772867 (1), 17439704 (1)
    neurodegenerative diseases 32.4 1 14644040 (1)
    schizophrenia 24.9 28 12425946 (5), 15234466 (4), 17022955 (3), 14741411 (2) (see all 8)
    scar 24 3 11597097 (1), 16646157 (1), 15566408 (1)
    multiple sclerosis 20.1 7 14644040 (2), 18495952 (2), 20437585 (1), 17356385 (1) (see all 5)
    small cell lung cancer 17.9 1 11494121 (1)
    tumors 5.29 6 17592524 (2), 12510146 (1), 11891768 (1), 18685489 (1)
    cancer 5.21 5 12510146 (2), 11494121 (2), 15781961 (1)
    neurological disorders 3.72 2 14644040 (2)

    Genetic Association Database (GAD): RTN4
    Human Genome Epidemiology (HuGE) Navigator: RTN4 (10 documents)

    Export disorders for RTN4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RTN4 gene, integrated from 10 sources (see all 223) (see top 10):
    (articles sorted by number of sources associating them with RTN4)

    1. Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. (PubMed id 10667797)1, 2, 3, 9 GrandPre T.... Strittmatter S.M. (Nature 2000)
    2. Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping. (PubMed id 10773680)1, 2, 3 Yang J.... Zhao S.-Y. (Cytogenet. Cell Genet. 2000)
    3. Genomic structure and functional characterisation of the promoters of human and mouse nogo/rtn4. (PubMed id 12488097)1, 2, 9 Oertle T.... Schwab M.E. (J. Mol. Biol. 2003)
    4. No association between the genetic polymorphisms within RTN4 and schizophrenia in the Chinese population. (PubMed id 15234466)1, 4, 9 Chen W....He L. (Neurosci. Lett. 2004)
    5. Nogo CAA 3'UTR Insertion polymorphism is not associated with Schizophrenia nor with bipolar disorder. (PubMed id 15820318)1, 4, 9 GregA^rio S.P....Dias-Neto E. (Schizophr. Res. 2005)
    6. Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration. (PubMed id 11891768)1, 2, 9 Ng C.E.L. and Tang B.L. (J. Neurosci. Res. 2002)
    7. Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. (PubMed id 16835300)1, 2, 9 Miao R.Q.... Sessa W.C. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    8. CAA insertion polymorphism in the 3'UTR of Nogo gene on 2p14 is not associated with schizophrenia. (PubMed id 15661375)1, 4, 9 Xiong L....Joober R. (Brain Res. Mol. Brain Res. 2005)
    9. Nogo 3'-untranslated region CAA insertion: failure to replicate association with schizophrenia and demonstration of marked population difference in frequency of the insertion. (PubMed id 14741411)1, 4, 9 Covault J....Kranzler H. (Brain Res. Mol. Brain Res. 2004)
    10. The association between dilated cardiomyopathy and RTN4 3'UTR insertion/deletion polymorphisms. (PubMed id 18948092)1, 4, 9 Zhou B....Zhang L. ( international journal of clinical chemistry 2009)
    11. Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein. (PubMed id 16965550)1, 2, 9 Murayama K.S.... Araki W. (Eur. J. Neurosci. 2006)
    12. Gender-specific association of insertion/deletion polymorphisms in the nogo gene and chronic schizophrenia. (PubMed id 15953657)1, 4, 9 Tan E.C....Teo Y.Y. (Brain Res. Mol. Brain Res. 2005)
    13. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. (PubMed id 11201742)1, 2, 9 Fournier A.E.... Strittmatter S.M. (Nature 2001)
    14. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    15. Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PubMed id 19054571)1, 4 GregA^rio S.P....Dias-Neto E. (Psychiatry Res 2009)
    16. A class of dynamin-like GTPases involved in the generation of the tubular ER network. (PubMed id 19665976)1, 2 Hu J.... Blackstone C. (Cell 2009)
    17. Common body mass index-associated variants confer risk of extreme obesity. (PubMed id 19553259)1, 4 Cotsapas C....Daly M.J. (Hum. Mol. Genet. 2009)
    18. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. (PubMed id 18583979)1, 4 Allen N.C....Bertram L. (Nat. Genet. 2008)
    19. Mapping of interaction domains mediating binding between BACE1 and RTN/Nogo proteins. (PubMed id 16979658)1, 2 He W.... Yan R. (J. Mol. Biol. 2006)
    20. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    21. Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation. (PubMed id 15286784)1, 2 He W.... Yan R. (Nat. Med. 2004)
    22. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    23. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    24. Pro-apoptotic ASY/Nogo-B protein associates with ASYIP. (PubMed id 12811824)1, 2 Qi B.... Yutsudo M. (J. Cell. Physiol. 2003)
    25. Expression of a novel reticulon-like gene in human testis. (PubMed id 11866689)1, 2 Zhou Z.M.... Zhou K.Y. (Reproduction 2002)
    26. Inhibitor of neurite outgrowth in humans. (PubMed id 10667780)1, 2 Prinjha R.... Walsh F.S. (Nature 2000)
    27. A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity. (PubMed id 11126360)1, 2 Tagami S.... Tsujimoto Y. (Oncogene 2000)
    28. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    29. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    30. NOGO mRNA expression in adult and fetal human and rat nervous tissue and in weight drop injury. (PubMed id 11358445)1, 9 Josephson A....Spenger C. (Exp. Neurol. 2001)
    31. Muscle Nogo-A expression is a prognostic marker in lower motor neuron syndromes. (PubMed id 17455292)1, 9 Pradat P.F....Meininger V. (Ann. Neurol. 2007)
    32. Negative correlation of Nogo-A with the malignancy of oligodendroglial tumor. (PubMed id 17592524)1, 9 Xiong N.X....He Z.Q. (Neurosci Bull 2007)
    33. Increased expression of Nogo-A in hippocampal neurons of patients with temporal lobe epilepsy. (PubMed id 15245492)1, 9 Bandtlow C.E....Sperk G. (Eur. J. Neurosci. 2004)
    34. Biochemical characterization of the recombinant human Nogo-A ectodomain. (PubMed id 17437522)1, 9 Zander H....Skerra A. (FEBS J. 2007)
    35. Increased expression of Noga-A in ALS muscle biopsies is not unique for this disease. (PubMed id 17626519)1, 9 Wojcik S....Askanas V. (Acta Myol 2006)
    36. [Functional interaction of the C-terminal of Nogo protein with connexin 26 and the expression of Nogo's mRNA in the murine inner ear]. (PubMed id 17029193)1, 9 Xiao Z.A....Pan Q. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006)
    37. Nogo A, B and C expression in schizophrenia, depression and bipolar frontal cortex, and correlation of Nogo expression with CAA/TATC polymorphism in 3'-UTR. (PubMed id 17022955)1, 9 Novak G. and Tallerico T. (Brain Res. 2006)
    38. Expression pattern of NOGO and NgR genes during human development. (PubMed id 15749087)1, 9 Al Halabiah H....Simonneau M. (Gene Expr. Patterns 2005)
    39. Schizophrenia and Nogo: elevated mRNA in cortex, and high prevalence of a homozygous CAA insert. (PubMed id 12425946)1, 9 Novak G....Tallerico T. (Brain Res. Mol. Brain Res. 2002)
    40. Identification of Nogo as a novel indicator of heart failure. (PubMed id 17971502)1, 9 Bullard T.A....Blaxall B.C. (Physiol. Genomics 2008)
    41. NOGO is increased and binds to BACE1 in sporadic inclusion-body myositis and in A beta PP-overexpressing cultured human muscle fibers. (PubMed id 17764014)1, 9 Wojcik S....Askanas V. (Acta Neuropathol. 2007)
    42. Nogo-A expression in the human hippocampus in normal aging and in Alzheimer disease. (PubMed id 16772867)1, 9 Gil V....del RA-o J.A. (J. Neuropathol. Exp. Neurol. 2006)
    43. Soluble Nogo-A in CSF is not a useful biomarker for multiple sclerosis. (PubMed id 18495952)1, 9 Lindsey J.W....Hatfield L.M. (Neurology 2008)
    44. Nogo provides a molecular marker for diagnosis of amyotrophic lateral sclerosis. (PubMed id 12270696)1, 9 Dupuis L....Loeffler J.P. (Neurobiol. Dis. 2002)
    45. Identification and structural mechanism for a novel interaction between a ubiquitin ligase WWP1 and Nogo-A, a key inhibitor for central nervous system regeneration. (PubMed id 19035836)1, 9 Qin H....Song J. (Biochemistry 2008)
    46. Nogo-a expression in glial CNS tumors: a tool to differentiate between oligodendrogliomas and other gliomas? (PubMed id 18685489)1, 9 Kuhlmann T....Bruck W. (Am. J. Surg. Pathol. 2008)
    47. Multi-functional gene ASY/Nogo/RTN-X/RTN4: apoptosis, tumor suppression, and inhibition of neuronal regeneration. (PubMed id 12510146)1, 9 Watari A. and Yutsudo M. (Apoptosis 2003)
    48. Protein microarray analysis identifies cyclic nucleotide phosphodiesterase as an interactor of Nogo-A. (PubMed id 19508346)1, 9 Sumiyoshi K....Satoh J. (Neuropathology 2010)
    49. Reticulon-4A (Nogo-A) redistributes protein disulfide isomerase to protect mice from SOD1-dependent amyotrophic lateral sclerosis. (PubMed id 19889996)1, 9 Yang Y.S....Strittmatter S.M. (J. Neurosci. 2009)
    50. The N-terminal domain of Nogo-A inhibits cell adhesion and axonal outgrowth by an integrin-specific mechanism. (PubMed id 18234903)1, 9 Hu F. and Strittmatter S.M. (J. Neurosci. 2008)
    51. Human Nogo-C overexpression induces HEK293 cell apoptosis via a mechanism that involves JNK-c-Jun pathway. (PubMed id 16905119)1, 9 Chen Y....Zhang X. (Biochem. Biophys. Res. Commun. 2006)
    52. The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI. (PubMed id 12692556)1, 9 Yamashita T. and Tohyama M. (Nat. Neurosci. 2003)
    53. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. (PubMed id 12089450)1, 9 Liu B.P.... Strittmatter S.M. (Science 2002)
    54. Association of genetic variations in RTN4 3'-UTR with risk of uterine leiomyomas. (PubMed id 23479081)1 Zhang K....Zhang L. (Pathol. Oncol. Res. 2013)
    55. TROY interacts with Rho guanine nucleotide dissociation inhibitor I+ (RhoGDII+) to mediate Nogo-induced inhibition of neurite outgrowth. (PubMed id 24129566)1 Lu Y....He C. (J. Biol. Chem. 2013)
    56. Nogo-B promotes the epithelial-mesenchymal transition in HeLa cervical cancer cells via Fibulin-5. (PubMed id 23042479)1 Xiao W....Qi Y. (Oncol. Rep. 2013)
    57. Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis. (PubMed id 23142642)1 Passantino R....Guarneri P. (Biochim. Biophys. Acta 2013)
    58. Absence of Nogo-B (reticulon 4B) facilitates hepatic stellate cell apoptosis and diminishes hepatic fibrosis in mice. (PubMed id 23313137)1 Tashiro K....Iwakiri Y. (Am. J. Pathol. 2013)
    59. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    60. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    61. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    62. Expression of nogo-a is decreased with increasing gestational age in the human fetal brain. (PubMed id 23146900)1 Haybaeck J....Weis S. (Dev. Neurosci. 2012)
    63. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    64. RNT4 3'-UTR insertion/deletion polymorphisms are not associated with atrial septal defect in Chinese Han population: a brief communication. (PubMed id 22313113)1 Li H....Rao L. (DNA Cell Biol. 2012)
    65. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    66. Genetic variation in RTN4 3'-UTR and susceptibility to cervical squamous cell carcinoma. (PubMed id 22320844)1 Shi S....Zhang L. (DNA Cell Biol. 2012)
    67. Nogo-A: a useful marker for the diagnosis of oligodendroglioma and for identifying 1p19q codeletion. (PubMed id 21835431)1 Marucci G....Foschini M.P. (Hum. Pathol. 2012)
    68. PKCI/ promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. (PubMed id 22304920)1 Lau E....Ronai Z.A. (Cell 2012)
    69. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    70. The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension. (PubMed id 21697531)1 Sutendra G....Michelakis E.D. (Sci Transl Med 2011)
    71. Nogo-A expression in oligodendroglial tumors. (PubMed id 20487307)1 Jung T.Y....Lee M.C. (Neuropathology 2011)
    72. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)
    73. A multi-domain fragment of Nogo-A protein is a potent inhibitor of cortical axon regeneration via Nogo receptor 1. (PubMed id 21454605)1 Huebner E.A....Strittmatter S.M. (J. Biol. Chem. 2011)
    74. [Significance of Nogo-A expression of atrophic muscle fibers in diagnosis of amyotrophic lateral sclerosis]. (PubMed id 21503119)1 Sun A.P....Fan D.S. (Beijing Da Xue Xue Bao 2011)
    75. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    76. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    77. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    78. The age- and amyloid-I^-related increases in Nogo B contribute to microglial activation. (PubMed id 21111015)1 Murphy K.J....Lynch M.A. (Neurochem. Int. 2011)
    79. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    80. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    81. Nogo-B regulates migration and contraction of airway smooth muscle cells by decreasing ARPC 2/3 and increasing MYL-9 expression. (PubMed id 21251247)1 Xu W....Li Q. (Respir. Res. 2011)
    82. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    83. Endothelial reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation. (PubMed id 21183689)1 Di Lorenzo A....Sessa W.C. (Blood 2011)
    84. Nogo receptor 3, a paralog of Nogo-66 receptor 1 (NgR1), may function as a NgR1 co-receptor for Nogo-66. (PubMed id 22133682)1 Zhang L....Zhang J. (J Genet Genomics 2011)
    85. Analysis of RTN4 3'UTR insertion/deletion polymorphisms in ventricular septal defect in a Chinese Han population. (PubMed id 21166502)1 Chen Y....Rao L. (DNA Cell Biol. 2011)
    86. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    87. Nogo-B mediates HeLa cell adhesion and motility through binding of Fibulin-5. (PubMed id 20599731)1 Zhou S....Qi Y. (Biochem. Biophys. Res. Commun. 2010)
    88. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    89. Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation. (PubMed id 20975041)1 Wright P.L....Sessa W.C. (J. Exp. Med. 2010)
    90. Dendritic spine alterations in neocortical pyramidal neurons following postnatal neuronal Nogo-A knockdown. (PubMed id 20938157)1 Pradhan A.D....Kartje G.L. (Dev. Neurosci. 2010)
    91. RTN3 and RTN4: Candidate modulators in vascular cell apoptosis and atherosclerosis. (PubMed id 20717916)1 Chen Y....Xiang R. (J. Cell. Biochem. 2010)
    92. Overcoming amino-Nogo-induced inhibition of cell spreading and neurite outgrowth by 12-O-tetradecanoylphorbol-13-acetate-type tumor promoters. (PubMed id 20018888)1 Deng K....Walsh F.S. (J. Biol. Chem. 2010)
    93. Identification and regulation of reticulon 4B (Nogo-B) in renal tubular epithelial cells. (PubMed id 20971739)1 Marin E.P....Sessa W.C. (Am. J. Pathol. 2010)
    94. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    95. Atherosclerotic progression attenuates the expression of Nogo-B in autopsied coronary artery: pathology and virtual histology intravascular ultrasound analysis. (PubMed id 19654939)1 Lee W.S....Ryu W.S. (J. Korean Med. Sci. 2009)
    96. Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. (PubMed id 19165527)1 Martins-de-Souza D....Turck C.W. (Eur Arch Psychiatry Clin Neurosci 2009)
    97. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (Mol. Cell. Proteomics 2009)
    98. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    99. New mutations of Nogo-C in hepatocellular carcinoma. (PubMed id 18080785)1 Chen Y.... Zhuang L. (Mol. Biol. Rep. 2009)
    100. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    101. Phosphorylation of Nogo receptors suppresses Nogo signaling, allowing neurite regeneration. (PubMed id 19336839)1 Takei Y. (Sci Signal 2009)
    102. Reassessment of corticospinal tract regeneration in Nogo-deficient mice. (PubMed id 19587271)1 Lee J.K....Zheng B. (J. Neurosci. 2009)
    103. The two-hydrophobic domain tertiary structure of reticulon proteins is critical for modulation of beta-secretase BACE1. (PubMed id 19405102)1 Kume H....Araki W. (J. Neurosci. Res. 2009)
    104. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1 Meierhofer D.... Kaiser P. (J. Proteome Res. 2008)
    105. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (Mol. Cell 2008)
    106. Reshaping of the endoplasmic reticulum limits the rate for nuclear envelope formation. (PubMed id 18779370)1 Anderson D.J. and Hetzer M.W. (J. Cell Biol. 2008)
    107. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    108. Soluble Nogo-A, an inhibitor of axonal regeneration, as a biomarker for multiple sclerosis. (PubMed id 17242333)1 Jurewicz A....Selmaj K. (Neurology 2007)
    109. Regulation of Nogo-B expression in the lesion of aortic aneurysms. (PubMed id 17645629)1 Pan J.W....Rui Y.C. (amp 2007)
    110. Roles of glial p75NTR in axonal regeneration. (PubMed id 17335080)1 Zhou X.F. and Li H.Y. (J. Neurosci. Res. 2007)
    111. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    112. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (Proteomics 2007)
    113. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M....Figeys D. (Mol. Syst. Biol. 2007)
    114. Nogo in the injured spinal cord. (PubMed id 16629624)1 Schweigreiter R. and Bandtlow C.E. (J. Neurotrauma 2006)
    115. Down-regulation of ASY/Nogo transcription associated with progression of adult T-cell leukemia/lymphoma. (PubMed id 16646068)1 Shimakage M....Yutsudo M. (Int. J. Cancer 2006)
    116. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    117. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
    118. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. (PubMed id 15694321)1 Park J.B....He Z. (Neuron 2005)
    119. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    120. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    121. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    122. Nogo-B is a new physiological substrate for MAPKAP-K2. (PubMed id 16095439)1 Rousseau S....Cohen P. (Biochem. J. 2005)
    123. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    124. Reticulon 4 in chondrocytic cells: barosensitivity and intracellular localization. (PubMed id 15147731)1 Sironen R.K....Lammi M.J. (amp 2004)
    125. Phosphoproteomic analysis of the developing mouse brain. (PubMed id 15345747)1 Ballif B.A....Gygi S.P. (amp 2004)
    126. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (Genome Res. 2004)
    127. A new role for Nogo as a regulator of vascular remodeling. (PubMed id 15034570)1 Acevedo L....Sessa W.C. (Nat. Med. 2004)
    128. Nogo-A at CNS paranodes is a ligand of Caspr: possible regulation of K(+) channel localization. (PubMed id 14592966)1 Nie D.Y....Xiao Z.C. (EMBO J. 2003)
    129. Do cancer cells die because of Nogo-B? (PubMed id 12618765)1 Oertle T....Schwab M.E. (Oncogene 2003)
    130. Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS. (PubMed id 12951563)1 Filbin M.T. (Nat. Rev. Neurosci. 2003)
    131. A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein. (PubMed id 12426574)1 Wong S.T....Poo M.M. (Nat. Neurosci. 2002)
    132. Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP). (PubMed id 12067236)1 Hu W.-H....Bethea J.R. (J. Neurochem. 2002)
    133. Nogo-66 receptor antagonist peptide promotes axonal regeneration. (PubMed id 12037567)1 GrandPre T.... Strittmatter S.M. (Nature 2002)
    134. Nogo-A expression in mature oligodendrocytes of rat spinal cord in association with specific molecules. (PubMed id 12377379)1 Taketomi M....Ide C. (Neurosci. Lett. 2002)
    135. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    136. Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. (PubMed id 10667796)1 Chen M.S....Schwab M.E. (Nature 2000)
    137. DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)1 Hartley J.L....Brasch M.A. (Genome Res. 2000)
    138. Molecular analysis of Nogo expression in the hippocampus during development and following lesion and seizure. (PubMed id 12692091)9 Meier S....Savaskan N.E. (FASEB J. 2003)
    139. The Nogo receptor, its ligands and axonal regeneration in the spinal cord; a review. (PubMed id 12815233)9 Hunt D....Anderson P.N. (J. Neurocytol. 2002)
    140. Hippocampal Nogo-A and neo-Timm's staining in amygdala kindling rats. (PubMed id 17439704)9 Takeda Y....Kobayashi H. (Neurol. Res. 2007)
    141. Nogo and Nogo-66 receptor in human and chick: implications for development and regeneration. (PubMed id 15305291)9 O'Neill P....Ferretti P. (Dev. Dyn. 2004)
    142. Nogo signaling and non-physical injury-induced nervous system pathology. (PubMed id 15619232)9 Teng F.Y. and Tang B.L. (J. Neurosci. Res. 2005)
    143. Soluble Nogo receptor down-regulates expression of neuronal Nogo-A to enhance axonal regeneration. (PubMed id 19901030)9 Peng X....Mata M. (J. Biol. Chem. 2010)
    144. Nogo-A and Nogo-66 receptor in amyotrophic lateral sclerosis. (PubMed id 18419791)9 Teng F.Y. and Tang B.L. (J. Cell. Mol. Med. 2008)
    145. Nogo, a star protein in reticulon family. (PubMed id 17704847)9 Wang M....Lu Y.P. (Neurosci Bull 2006)
    146. Cytokines and neurotrophic factors fail to affect Nogo-A mRNA expression in differentiated human neurones: implications for inflammation-related axonal regeneration in the central nervous system. (PubMed id 11972796)9 Satoh J.I. and Kuroda Y. (Neuropathol. Appl. Neurobiol. 2002)
    147. The N- and C-termini of the human Nogo molecules are intrinsically unstructured: bioinformatics, CD, NMR characterization, and functional implications. (PubMed id 17397058)9 Li M. and Song J. (Proteins 2007)
    148. Silencing Nogo-A promotes functional recovery in demyelinating disease. (PubMed id 20437585)9 Yang Y....Lovett-Racke A.E. (Ann. Neurol. 2010)
    149. Molecular regulation of Nogo-A in neural cells: Novel insights into structure and function. (PubMed id 20171301)9 Bongiorno D. and Petratos S. (amp 2010)
    150. Changes of Nogo-A and receptor NgR in the lumbar spinal cord of ALS model mice. (PubMed id 19243684)9 Miyazaki K....Abe K. (Neurol. Res. 2009)
    151. Effect of Nogo-A gene inhibition on dopamine release in PC12 cells. (PubMed id 19112410)9 Xiong N.X....Zhang F.C. (Neuro Endocrinol. Lett. 2008)
    152. Nogo: a molecular determinant of axonal growth and regeneration. (PubMed id 11597097)9 GrandprAc T. and Strittmatter S.M. (Neuroscientist 2001)
    153. Oligodendrocyte precursor cells differentially expressing Nogo-A but not MAG are more permissive to neurite outgrowth than mature oligodendrocytes. (PubMed id 19236864)9 Ma Z....Xu X.M. (Exp. Neurol. 2009)
    154. Characterization of myelin ligand complexes with neuronal Nogo-66 receptor family members. (PubMed id 17189258)9 LaurAcn J....Strittmatter S.M. (J. Biol. Chem. 2007)
    155. Nogo-A is a reliable oligodendroglial marker in adult human and mouse CNS and in demyelinated lesions. (PubMed id 17356385)9 Kuhlmann T....BrA1ck W. (J. Neuropathol. Exp. Neurol. 2007)
    156. No go for brain tumors? (PubMed id 15781961)9 Teng F.Y. and Tang B.L. (J. Mol. Neurosci. 2005)
    157. Structural characterization of the human Nogo-A functional domains. Solution structure of Nogo-40, a Nogo-66 receptor antagonist enhancing injured spinal cord regeneration. (PubMed id 15317586)9 Li M....Song J. (Eur. J. Biochem. 2004)
    158. New insights on neuronal alterations in jimpy mutant brain. (PubMed id 15139292)9 Harsan L....Ghandour M.S. (Neurochem. Res. 2004)
    159. Serum and cerebrospinal fluid antibodies to Nogo-A in patients with multiple sclerosis and acute neurological disorders. (PubMed id 14644040)9 Reindl M....Bandtlow C.E. (J. Neuroimmunol. 2003)
    160. Nogo-A and myelin-associated glycoprotein mediate neurite growth inhibition by antagonistic regulation of RhoA and Rac1. (PubMed id 12451136)9 NiederAPst B....Bandtlow C.E. (J. Neurosci. 2002)
    161. Cell autonomous function of Nogo and reticulons: The emerging story at the endoplasmic reticulum. (PubMed id 18330888)9 Teng F.Y. and Tang B.L. (J. Cell. Physiol. 2008)
    162. Targeting the Nogo-A signalling pathway to promote recovery following acute CNS injury. (PubMed id 17692015)9 Walmsley A.R. and Mir A.K. (Curr. Pharm. Des. 2007)
    163. Knocking-down of Nogo-A gene expression in PC12 cell line by plasmid-based RNAi. (PubMed id 17828504)9 Xiong N....Yao D. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2007)
    164. Reticulon proteins: emerging players in neurodegenerative diseases. (PubMed id 16505974)9 Yan R....Zhou X. (Cell. Mol. Life Sci. 2006)
    165. The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model. (PubMed id 17039253)9 Jokic N....Loeffler J.P. (EMBO Rep. 2006)
    166. Expression pattern of NOGO-A protein in the human nervous system. (PubMed id 15616791)9 Buss A....Brook G.A. (Acta Neuropathol. 2005)
    167. Truncated soluble Nogo receptor binds Nogo-66 and blocks inhibition of axon growth by myelin. (PubMed id 12388594)9 Fournier A.E....Strittmatter S.M. (J. Neurosci. 2002)
    168. Nogo-A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury. (PubMed id 12379801)9 Pot C....Schwab M.E. (J. Cell Biol. 2002)
    169. Genomic organization of the human NSP gene, prototype of a novel gene family encoding reticulons. (PubMed id 8833145)9 Roebroek A.J.M.... Van de Ven W.J.M. (Genomics 1996)
    170. Pincher-generated Nogo-A endosomes mediate growth cone collapse and retrograde signaling. (PubMed id 20083601)9 Joset A....Schwab M.E. (J. Cell Biol. 2010)
    171. Bone marrow stromal cells stimulate neurite outgrowth over neural proteoglycans (CSPG), myelin associated glycoprotein and Nogo-A. (PubMed id 17234155)9 Wright K.T....Johnson W.E. (Biochem. Biophys. Res. Commun. 2007)
    172. Neuronal responses to myelin are mediated by rho kinase. (PubMed id 16441511)9 Alabed Y.Z....Fournier A.E. (J. Neurochem. 2006)
    173. Nogo goes in the pure water: solution structure of Nogo-60 and design of the structured and buffer-soluble Nogo-54 for enhancing CNS regeneration. (PubMed id 16877707)9 Li M....Song J. (Protein Sci. 2006)
    174. Nogo-A interacts with the Nogo-66 receptor through multiple sites to create an isoform-selective subnanomolar agonist. (PubMed id 15930377)9 Hu F....Strittmatter S.M. (J. Neurosci. 2005)
    175. Nogo expression in muscle correlates with amyotrophic lateral sclerosis severity. (PubMed id 15786457)9 Jokic N....Meininger V. (Ann. Neurol. 2005)
    176. Inhibition of Nogo: a key strategy to increase regeneration, plasticity and functional recovery of the lesioned central nervous system. (PubMed id 16338758)9 Buchli A.D. and Schwab M.E. (Ann. Med. 2005)
    177. Promotion of axon regeneration by myelin-associated glycoprotein and Nogo through divergent signals downstream of Gi/G. (PubMed id 15282288)9 Hasegawa Y....Yamashita T. (J. Neurosci. 2004)
    178. Olfactory ensheathing cell phenotype following implantation in the lesioned spinal cord. (PubMed id 14618270)9 Woodhall E....Chuah M.I. (Cell. Mol. Life Sci. 2003)
    179. Regeneration in the central nervous system. (PubMed id 12543264)9 Bandtlow C.E. (Exp. Gerontol. 2003)
    180. Link of a new type of apoptosis-inducing gene ASY/Nogo-B to human cancer. (PubMed id 11494121)9 Li Q....Yutsudo M. (Oncogene 2001)
    181. Carbamazepine protects against megencephaly and abnormal expression of BDNF and Nogo signaling components in the mceph/mceph mouse. (PubMed id 16990009)9 Lavebratt C....Schalling M. (Neurobiol. Dis. 2006)
    182. Expression of neurodevelopmental markers by cultured porcine neural precursor cells. (PubMed id 16100001)9 Schwartz P.H....Klassen H. (Stem Cells 2005)
    183. Identification of a functional epitope of the Nogo receptor by a combinatorial approach using ribosome display. (PubMed id 16061255)9 Schimmele B. and PlA1ckthun A. (J. Mol. Biol. 2005)
    184. Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. (PubMed id 12839991)9 Barton W.A.... Nikolov D.B. (EMBO J. 2003)
    185. Nogo (Reticulon 4) expression in innervated and denervated mouse skeletal muscle. (PubMed id 12691732)9 Magnusson C....TAYgerud S. (Mol. Cell. Neurosci. 2003)
    186. Nogo on the go. (PubMed id 12408839)9 McKerracher L. and Winton M.J. (Neuron 2002)
    187. Nogo-receptor gene activity: cellular localization and developmental regulation of mRNA in mice and humans. (PubMed id 12378589)9 Josephson A....Spenger C. (J. Comp. Neurol. 2002)
    188. Neuroendocrine-specific protein C, a marker of neuronal differentiation, is reduced in brain of patients with Down syndrome and Alzheimer's disease. (PubMed id 11006125)9 Kim S.H....Lubec G. (Biochem. Biophys. Res. Commun. 2000)
    189. Receptors for myelin inhibitors: Structures and therapeutic opportunities. (PubMed id 19619659)9 Cao Z....Walsh F.S. (Mol. Cell. Neurosci. 2010)
    190. Nogo-A expresses on neural stem cell surface. (PubMed id 20374087)9 Hou T....Xiao C. (Int. J. Neurosci. 2010)
    191. NgR acts as an inhibitor to axonal regeneration in adults. (PubMed id 17981689)9 Zhang S....Qin X. (Front. Biosci. 2008)
    192. Regional-specific regulation of BDNF and trkB correlates with nigral dopaminergic cell sprouting following unilateral nigrostriatal axotomy. (PubMed id 18338800)9 GarcA-a Navia J.T....Venero J.L. (J. Neurosci. Res. 2008)
    193. The therapeutic effects of Rho-ROCK inhibitors on CNS disorders. (PubMed id 18827856)9 Kubo T....Yamashita T. (Ther Clin Risk Manag 2008)
    194. Nogo-A inhibition induces recovery from neglect in rats. (PubMed id 17963852)9 Brenneman M.M....Schwab M.E. (Behav. Brain Res. 2008)
    195. Rho-ROCK inhibitors for the treatment of CNS injury. (PubMed id 18221230)9 Kubo T. and Yamashita T. (Recent Pat CNS Drug Discov 2007)
    196. TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions. (PubMed id 17239012)9 Satoh J....Konno H. (Neuropathol. Appl. Neurobiol. 2007)
    197. The Nogo-66 receptor NgR1 is required only for the acute growth cone-collapsing but not the chronic growth-inhibitory actions of myelin inhibitors. (PubMed id 17611264)9 Chivatakarn O....Giger R.J. (J. Neurosci. 2007)

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