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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RTN4 Gene

protein-coding   GIFtS: 66
GCID: GC02M055199

reticulon 4
 Explore 33 diseases affiliated with
RTN4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RTN4    

Aliases
for RTN4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Reticulon 41 2     RTN4-A2
NOGO1 2 3 5     RTN4-B12
ASY1 2     RTN4-B22
NSP-CL1 2     RTN4-C2
KIAA08861 3     Foocen3
Neurite Outgrowth Inhibitor2 3     Human NogoA2
Neuroendocrine-Specific Protein C Homolog2 3     My043 Protein2
NSP2 3     Neurite Growth Inhibitor 2202
NI220/2502     Reticulon 52
NOGO-A2     Reticulon-41
NOGOC2     Foocen3
Nbla002712     RTN-X2
Nbla105452     Reticulon-53
Nogo-B2     Neuroendocrine-Specific Protein3
Nogo-C2     Nogo Protein3
RTN-X2     

External Ids:    HGNC: 140851   Entrez Gene: 571422   Ensembl: ENSG000001153107   OMIM: 6044755   UniProtKB: Q9NQC33   

Export aliases for RTN4 gene to outside databases

Previous GC identifers: GC02M055237 GC02M055386 GC02M055173 GC02M055110 GC02M054934


Summaries
for RTN4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RTN4:
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum,
and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this
gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system
in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and
differential promoter usage and encoding different isoforms have been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3
Function: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and
growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the
developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of
plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing
receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely
consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding
and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing

Gene Wiki entry for RTN4 (Reticulon 4)


Genomic Views
for RTN4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RTN4 gene promoter:
         POU2F1   POU2F1a   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 10): RTN4 promoter sequence
   Search SABiosciences Chromatin IP Primers for RTN4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RTN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.3   Ensembl cytogenetic band:  2p16.1   HGNC cytogenetic band: 2p14-p13

RTN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTN4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M055199:  view genomic region     (about GC identifiers)

Start:
 55,199,325 bp from pter      End:
 55,339,757 bp from pter
Size:
 140,433 bases      Orientation:
 minus strand

Proteins
for RTN4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3 (See protein sequence)
Recommended Name: Reticulon-4  
Size: 1192 amino acids; 129931 Da
Subunit: Binds to RTN4R. Interacts with Bcl-xl and Bcl-2. Isoform 2 binds to NGBR and RTN3. Isoform 2 and isoform 3
interact with BACE1 and BACE2. Interacts with RTN4IP1. Interacts with ATL1
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Anchored to the membrane of the
endoplasmic reticulum through 2 putative transmembrane domains
Sequence caution: Sequence=AAD39920.1; Type=Frameshift; Positions=1149, 1156; Sequence=AAG43160.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAG43160.1; Type=Frameshift; Positions=684, 700;
Sequence=BAA74909.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for RTN4:
2G31 (3D)        2JV5 (3D)    
Secondary accessions: O94962 Q7L7Q5 Q7L7Q6 Q7L7Q8 Q8IUA4 Q96B16 Q9BXG5 Q9H212 Q9H3I3 Q9UQ42 Q9Y293
Q9Y2Y7 Q9Y5U6
Alternative splicing: 6 isoforms:  Q9NQC3-1   Q9NQC3-2   Q9NQC3-3   Q9NQC3-4   Q9NQC3-5   Q9NQC3-6   

Explore the universe of human proteins at neXtProt for RTN4: NX_Q9NQC3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NQC3

    • RTN4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_008939.1  NP_065393.1  NP_722550.1  NP_997403.1  NP_997404.1  

    ENSEMBL proteins: 
     ENSP00000378107   ENSP00000384471   ENSP00000349944   ENSP00000337838   ENSP00000322147  
     ENSP00000350365   ENSP00000378109   ENSP00000385650   ENSP00000397808   ENSP00000411628  
     ENSP00000384825   ENSP00000346465  
    Reactome Protein details: Q9NQC3
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for RTN4 (Nogo-A)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): RTN4
    OriGene Protein Over-expression Lysate (see all 5): RTN4
    OriGene Custom Protein Services for RTN4 
    GenScript Custom Purified and Recombinant Proteins Services for RTN4
    Novus Biologicals RTN4 Proteins
    Novus Biologicals RTN4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RTN4

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IDA11126360
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum NAS11126360
    GO:0005886plasma membrane TAS--
    GO:0030176integral to endoplasmic reticulum membrane IDA10667797


    RTN4 for ontologies           About GeneDecksing



    RTN4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RTN4
    R&D Systems Antibodies for RTN4 (Nogo-A, Nogo-B, Nogo-C)
    OriGene Antibodies (see all 2): RTN4
    OriGene Custom Antibody Services for RTN4 
    GenScript Custom Superior Antibodies Services for RTN4
    Novus Biologicals RTN4 Antibodies
    Search for Antibodies for RTN4 at Abcam  
    Uscn Antibodies for RTN4
    ThermoFisher Antibodies for RTN4

    Assay Products for RTN4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RTN4
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RTN4

    Protein Domains /
    Families
    for RTN4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RTN4 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR003388 Reticulon

    Graphical View of Domain Structure for InterPro Entry Q9NQC3

    ProtoNet protein and cluster: Q9NQC3

    1 Blocks protein family: IPB003388 Reticulon

    UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3
    Domain: Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane domains,
    known as Nogo-66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the spreading of
    neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity)
    Similarity: Contains 1 reticulon domain


    Function
    for RTN4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3
    Function: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and
    growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the
    developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of
    plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing
    receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely
    consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding
    and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing

    miRNA
    Products:            		miRTarBase miRNAs that target RTN4:
    hsa-mir-16 (MIRT001421), hsa-mir-21 (MIRT000167)

    OriGene 3'-UTR Clone (see all 5): RTN4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RTN4
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RTN4 (see all 19):
    hsa-miR-4318 hsa-miR-15a hsa-miR-503 hsa-miR-3692 hsa-miR-424 hsa-miR-195 hsa-miR-497* hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmid: RTN4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RTN4 (see all 7)
    OriGene shRNA RFP: RTN4
    OriGene siRNA: RTN4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RTN4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RTN4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RTN4 (see all 12)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RTN4 (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): RTN4 (NM_020532)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RTN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTN4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RTN4
    Search LifeMap BioReagents cell lines for RTN4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19665976
    GO:0032403protein complex binding ----


    RTN4 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for RTN4: Rtn4tm1Schw Rtn4tm2.1Matl Rtn4tm2Matl
         4 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Rtn4):
     cellular  mortality/aging  nervous system  normal 

    RTN4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RTN4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axonal growth inhibition (RHOA activation)
    		Axonal growth inhibition (RHOA activation)1.00
    		p75NTR regulates axonogenesis0.90
    2Development MAG-dependent inhibition of neurite outgrowth
    		Development MAG-dependent inhibition of neurite outgrowth1.00
    		Development_MAG-dependent inhibition of neurite outgrowth0.87
    3NgR-p75(NTR)-Mediated Signaling
    		NgR-p75(NTR)-Mediated Signaling1.00
    4p75(NTR)-mediated signaling
    		p75(NTR)-mediated signaling1.00
    5Cell death signalling via NRAGE, NRIF and NADE
    		p75 NTR receptor-mediated signalling0.73

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for RTN4
        Development MAG-dependent inhibition of neurite outgrowth

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RTN4
        NgR-p75(NTR)-Mediated Signaling

    1 GeneGo (Thomson Reuters) Pathway for RTN4
        Development MAG-dependent inhibition of neurite outgrowth

    1 BioSystems Pathway for RTN4 
        p75(NTR)-mediated signaling

    5        Reactome Pathways for RTN4
        Axonal growth inhibition (RHOA activation)
    Signal Transduction
    p75NTR regulates axonogenesis
    Signalling by NGF
    p75 NTR receptor-mediated signalling



    RTN4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RTN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/65 Interacting proteins for RTN4 (Q9NQC31, 2, 3 ENSP000003378384) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COL4A3BPQ9Y5P42, 3, ENSP000003698624MINT-68370 I2D: score=5 STRING: ENSP00000369862
    FXR2P511162, 3, ENSP000002501134MINT-67869 I2D: score=5 STRING: ENSP00000250113
    CRMP1Q141942, 3, ENSP000003216064MINT-65114 I2D: score=4 STRING: ENSP00000321606
    ABL1P005192, 3, ENSP000003614234MINT-8110731 I2D: score=3 STRING: ENSP00000361423
    FYNP062412, 3, ENSP000003576564MINT-8111499 I2D: score=3 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006915apoptotic process NAS11126360
    GO:0007399nervous system development ----
    GO:0007413axonal fasciculation ISS--
    GO:0007568aging ----


    RTN4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RTN4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RTN4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RTN4
    1 Novoseek chemical compound relationship for RTN4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ddvp 58 1 17029193 (1)

    Search CenterWatch for drugs/clinical trials and news about RTN4 

    Transcripts
    for RTN4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RTN4 gene (5 alternative transcripts): 
    NM_007008.2  NM_020532.4  NM_153828.2  NM_207520.1  NM_207521.1  

    Unigene Cluster for RTN4:

    Reticulon 4
    Hs.743996  [show with all ESTs]
    Unigene Representative Sequence: NM_020532
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394609(uc002ryc.3) ENST00000405240 ENST00000357376(uc002ryd.3)
    ENST00000337526(uc002rye.3) ENST00000317610(uc002ryg.3) ENST00000357732(uc002ryf.3)
    ENST00000394611 ENST00000404909 ENST00000486085 ENST00000491592 ENST00000485749
    ENST00000438462 ENST00000427710 ENST00000461004 ENST00000402434 ENST00000354474


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 5): RTN4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RTN4
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RTN4 (see all 19):
    hsa-miR-4318 hsa-miR-15a hsa-miR-503 hsa-miR-3692 hsa-miR-424 hsa-miR-195 hsa-miR-497* hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmid: RTN4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RTN4 (see all 7)
    OriGene shRNA RFP: RTN4
    OriGene siRNA: RTN4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RTN4
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RTN4 (see all 12)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): RTN4 (NM_020532)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTN4

    Additional cDNA sequence: 

    AB015639.1 AB020693.1 AB040462.1 AB040463.1 AB073351.1 AB073359.1 AF063601.1 AF077050.1 
    AF087901.1 AF125103.1 AF132047.1 AF132048.1 AF148537.1 AF148538.1 AF177332.1 AF320999.1 
    AF333336.1 AJ251383.1 AJ251384.1 AJ251385.1 AK075039.1 AK098385.1 AK129806.1 AK130812.1 
    AK172726.1 AK302741.1 AY102276.1 AY102277.1 AY102278.1 AY102279.1 AY123245.1 AY123246.1 
    AY123247.1 AY123248.1 AY123249.1 AY123250.1 BC001035.2 BC007109.1 BC010737.1 BC012619.1 
    BC014366.1 BC016165.1 BC026788.1 BC068991.1 BC071848.1 BC150182.1 BC152425.1 BC152555.1 
    DQ778739.1 

    24/70 DOTS entries (see all 70):

    DT.87018236  DT.92057768  DT.91855184  DT.97862663  DT.100039375  DT.95148397  DT.100889622  DT.100039374 
    DT.97776594  DT.100889645  DT.100039372  DT.121021010  DT.100889631  DT.420660  DT.100889638  DT.100889649 
    DT.100889641  DT.100889621  DT.121021012  DT.408266  DT.95329023  DT.95128616  DT.100889636  DT.102838873 

    24/1507 AceView cDNA sequences (see all 1507):

    W19399 BM470283 CA421240 AU104979 AA081525 BG570231 AW169711 BM983902 
    T32248 AB040462 AA329816 AA911774 AI699241 AI348346 AY123250 BM709730 
    AI066675 AW264441 BM677436 W21129 CB108617 AW305370 AA576133 BU729639 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for RTN4 (see all 18)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d ^ 16 ^
    SP1:        -     -     -     -     -     -     -     -     -     -                 -     -     -                       -           -     -                     
    SP2:                          -     -     -     -     -     -     -                 -     -     -                       -           -     -                     
    SP3:                                      -     -     -     -     -                 -     -     -                       -           -     -                     
    SP4:                                                  -     -     -                 -     -     -                       -           -     -                     
    SP5:                                                        -     -                 -     -     -                       -           -     -                     

    ExUns: 17a · 17b · 17c · 17d
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for RTN4

    Expression
    for RTN4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RTN4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAATGCCACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RTN4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeRetinaEye
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RTN4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RTN4

    SOURCE GeneReport for Unigene cluster: Hs.743996

    UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3
    Tissue specificity: Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle.
    Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes.
    Isoform 4 is testis-specific

        SABiosciences Expression via Pathway-Focused PCR Arrays including RTN4: 
              Neurogenesis in human mouse rat
              Nephrotoxicity in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for RTN4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RTN4 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RTN41 reticulon 4 65.24(n)
    54.37(a)    		   378790  XM_003640893.1  XP_003640941.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RTN46
    		 --
    		 45(a)
    		 1 ↔ 1
    		 1(263837302-263900362)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC684892 hypothetical protein MGC68489 78.12(n)    BC059960.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.247182 Transcribed sequence with weak similarity to protein more 74.33(n)    57038777 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Rtnl26
    Rtnl16
    (see all 3)    		 Rtnl1
    (see all 3)    		 24(a)
    23(a)
    (see all 3)    		 possible ortholog
    1 ↔ many
    (see all 3)    		 3R(3354586-3355963)
    2L(4992808-5009720)


    ENSEMBL Gene Tree for RTN4 (if available)
    TreeFam Gene Tree for RTN4 (if available) 

    Paralogs
    for RTN4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RTN4 gene
    RTN32  RTN12  RTN22  
    6 SIMAP similar genes for RTN4 using alignment to 10 protein entries:     RTN4_HUMAN (see all proteins):
    NOGOC    Nbla10545    Nbla00271    RTN3    RTN1    RTN2

    RTN4 for paralogs           About GeneDecksing



    Genomic Variants
    for RTN4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1829 NCBI SNPs in RTN4 are shown (see all 1829)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1505009551,2
    		--55198856(+) CATGTC/TTGCCT 6 -- ut31 ds50010--------
    rs774080681,2
    		F,--55198935(+) CGATTA/GATGAT 6 -- ds5001 ut311Minor allele frequency- G:0.09WA 118
    rs787088271,2
    		--55199052(+) CTGCAC/GTGTAT 6 -- ut31 ds50011Minor allele frequency- G:0.01NA 120
    rs8871,2
    		C,F,O,A,H,--55199068(-) TTAACT/CCACAT 6 -- ds5001 ut3135Minor allele frequency- C:0.23MN EA NA NS WA CSA 5199
    rs800983851,2
    		F,--55199090(+) ATGAAT/ATTATT 6 -- ut31 ds50011Minor allele frequency- A:0.06WA 118
    rs1910984871,2
    		--55199112(+) AAACAC/TATCAC 6 -- ut31 ds50010--------
    rs38390541,2
    		C--55199171(-) AACAA-/AAGTCAA 6 -- ds50010--------
    rs589239601,2
    		C,--55199171(+) TTGAC-/TTTTGTT 6 -- ds50010--------
    rs1832858611,2
    		--55199184(+) CCACAA/GTAAAC 6 -- ds50010--------
    rs1388756101,2
    		--55199186(+) ACAGT-/AAAC  
                AAACA     		6 -- ds50010--------

    HapMap Linkage Disequilibrium report for RTN4 (55199325 - 55339757 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for RTN4
         2 CNVs: 97862 97861

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RTN4
    DNA2.0 Custom Variant and Variant Library Synthesis for RTN4

    Disorders / Diseases
    for RTN4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RTN4 for disorders           About GeneDecksing

    OMIM gene information: 604475    OMIM disorders: --

    20/33 diseases for RTN4 (see all 33):    About MalaCards
    inclusion body myositis    ventricular septal defect    amyotrophic lateral sclerosis    temporal lobe epilepsy
    pathological gambling    cerebral artery occlusion    lateral sclerosis    cerebrovascular accident
    aortic aneurysm    adult t-cell leukemia    multiple sclerosis    dilated cardiomyopathy
    neurodegenerative disease    myositis    leukemia/lymphoma    cardiomyopathy
    bipolar disorder    pulmonary hypertension    t-cell leukemia    alzheimer's disease

    3 diseases from the University of Copenhagen DISEASES database for RTN4:
    Amyotrophic lateral sclerosis     Multiple sclerosis     Cerebrovascular accident

    10/12 Novoseek disease relationships for RTN4 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amyotrophic lateral sclerosis 60.8 15 15786457 (3), 18419791 (2), 12270696 (1), 19889996 (1) (see all 9)
    epilepsy temporal lobe 33.9 4 15619232 (1), 15245492 (1), 16772867 (1), 17439704 (1)
    neurodegenerative diseases 32.4 1 14644040 (1)
    schizophrenia 24.9 28 12425946 (5), 15234466 (4), 17022955 (3), 14741411 (2) (see all 8)
    scar 24 3 11597097 (1), 16646157 (1), 15566408 (1)
    multiple sclerosis 20.1 7 14644040 (2), 18495952 (2), 20437585 (1), 17356385 (1) (see all 5)
    small cell lung cancer 17.9 1 11494121 (1)
    tumors 5.29 6 17592524 (2), 12510146 (1), 11891768 (1), 18685489 (1)
    cancer 5.21 5 12510146 (2), 11494121 (2), 15781961 (1)
    neurological disorders 3.72 2 14644040 (2)

    Genetic Association Database (GAD): RTN4
    Human Genome Epidemiology (HuGE) Navigator: RTN4 (10 documents)

    Export disorders for RTN4 gene to outside databases

    Publications
    for RTN4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RTN4 gene, integrated from 9 sources (see all 210):
    (articles sorted by number of sources associating them with RTN4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. (PubMed id 10667797)1, 2, 3, 9 GrandPre T.... Strittmatter S.M. (2000)
    2. Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping. (PubMed id 10773680)1, 2, 3 Yang J.... Zhao S.-Y. (2000)
    3. Genomic structure and functional characterisation of the promoters of human and mouse nogo/rtn4. (PubMed id 12488097)1, 2, 9 Oertle T.... Schwab M.E. (2003)
    4. No association between the genetic polymorphisms within RTN4 and schizophrenia in the Chinese population. (PubMed id 15234466)1, 4, 9 Chen W....He L. (2004)
    5. Nogo CAA 3'UTR Insertion polymorphism is not associated with Schizophrenia nor with bipolar disorder. (PubMed id 15820318)1, 4, 9 Gregorio S.P....Dias-Neto E. (2005)
    6. Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration. (PubMed id 11891768)1, 2, 9 Ng C.E.L. and Tang B.L. (2002)
    7. Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. (PubMed id 16835300)1, 2, 9 Miao R.Q.... Sessa W.C. (2006)
    8. CAA insertion polymorphism in the 3'UTR of Nogo gene on 2p14 is not associated with schizophrenia. (PubMed id 15661375)1, 4, 9 Xiong L....Joober R. (2005)
    9. Nogo 3'-untranslated region CAA insertion: failure to replicate association with schizophrenia and demonstration of marked population difference in frequency of the insertion. (PubMed id 14741411)1, 4, 9 Covault J....Kranzler H. (2004)
    10. Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein. (PubMed id 16965550)1, 2, 9 Murayama K.S.... Araki W. (2006)

    External Searches for RTN4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RTN4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57142 HGNC: 14085 AceView: RTN4 Ensembl:ENSG00000115310 euGenes: HUgn57142
    ECgene: RTN4 H-InvDB: RTN4

    Other Databases showing RTN4 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0886

    Specialized Databases showing RTN4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RTN4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RTN4 Genetics and Cytogenetics in Oncology and Haematology
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=R&genename=RTN4+%40+NOGO
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt069.shtml

    Intellectual Property
    for RTN4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RTN4 gene:
    Search GeneIP for patents involving RTN4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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