Aliases for RTN4 Gene
Aliases for RTN4 Gene
External Ids for RTN4 Gene
- HGNC: 14085
- Entrez Gene: 57142
- Ensembl: ENSG00000115310
- OMIM: 604475
- UniProtKB: Q9NQC3
Previous GeneCards Identifiers for RTN4 Gene
- GC02M055237
- GC02M055386
- GC02M055173
- GC02M055110
- GC02M055199
Summaries for RTN4 Gene
-
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for RTN4 Gene
RTN4 (Reticulon 4) is a Protein Coding gene. Diseases associated with RTN4 include Demyelinating Disease and Pedophilia. Among its related pathways are p75 NTR receptor-mediated signalling and Spinal Cord Injury. An important paralog of this gene is RTN1.
UniProtKB/Swiss-Prot for RTN4 Gene
-
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. Induces the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:25612671, PubMed:24262037, PubMed:27619977). Regulates membrane morphogenesis in the ER by promoting tubular ER production (PubMed:27619977). Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTN4 Gene
Genomics for RTN4 Gene
GeneHancer (GH) Regulatory Elements for RTN4 Gene
Promoters and enhancers for RTN4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around RTN4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the RTN4 gene promoter:
Genomic Locations for RTN4 Gene
Genomic Locations for RTN4 Gene
- chr2:54,972,187-55,112,621
- (GRCh38/hg38)
- Size:
- 140,435 bases
- Orientation:
- Minus strand
- chr2:55,199,325-55,339,757
- (GRCh37/hg19)
Genomic View for RTN4 Gene
Genes around RTN4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p16.1 by Ensembl
- 2p16.1 by Entrez Gene
- 2p16.1 by HGNC
RTN4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RTN4 Gene
Proteins for RTN4 Gene
-
Protein details for RTN4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NQC3-RTN4_HUMAN
- Recommended name:
- Reticulon-4
- Protein Accession:
- Q9NQC3
- O94962
- Q7L7Q5
- Q7L7Q6
- Q7L7Q8
- Q8IUA4
- Q96B16
- Q9BXG5
- Q9H212
- Q9H3I3
- Q9UQ42
- Q9Y293
- Q9Y2Y7
- Q9Y5U6
Protein attributes for RTN4 Gene
- Size:
- 1192 amino acids
- Molecular mass:
- 129931 Da
- Quaternary structure:
-
- Binds to RTN4R. Interacts with Bcl-xl and Bcl-2. Isoform 2 binds to NGBR and RTN3. Isoform 2 and isoform 3 interact with BACE1 and BACE2. Interacts with RTN4IP1. Interacts with ATL1. Interacts with TMEM170A (PubMed:26906412). Isoform 3 interacts with TMEM33 (PubMed:25612671).
- SequenceCaution:
-
- Sequence=AAD39920.1; Type=Frameshift; Positions=1149, 1156; Evidence={ECO:0000305}; Sequence=AAG43160.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAG43160.1; Type=Frameshift; Positions=684, 700; Evidence={ECO:0000305}; Sequence=BAA74909.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for RTN4 Gene
Post-translational modifications for RTN4 Gene
- Ubiquitination at posLast=10901090 and isoforms=2, 3, 4, 5, 61171
Other Protein References for RTN4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for RTN4 (Nogo-C)
- R&D Systems Antibodies for RTN4 (Nogo-B)
- R&D Systems Antibodies for RTN4 (Nogo-A)
- Cell Signaling Technology (CST) Antibodies for RTN4 (Nogo)
-
Custom Antibody ServicesOriGene Antibodies for RTN4
- Novus Biologicals Antibodies for RTN4
-
Cloud-Clone Corp. Antibodies for RTN4
- Invitrogen Antibodies for RTN4
- antibodies-online: Search results for 156 available RTN4 Antibodies ranked by validation data
- Compare Top RTN4 Antibodies
-
Recommended
- 2 IP Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 82 WB Antibodies (anti-rat)
- 1 IHC Antibody (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 80 WB Antibodies (anti-mouse)
- 1 IHC Antibody (anti-human)
- 2 IP Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 15 IF (p) Antibodies (anti-human)
- 101 WB Antibodies (anti-human)
- GeneTex RTN4 antibody for RTN4
-
Custom Antibody ServicesProSci Antibodies for RTN4
-
Santa Cruz Biotechnology (SCBT) Antibodies for RTN4
- Sino Biological Antibodies for RTN4
Protein Products
- R&D Systems Proteins and Enzymes for RTN4 (Nogo-A)
- Search Origene for MassSpec and Protein Over-expression Lysates for RTN4
- Origene Custom Protein Services for RTN4
- Sino Biological Recombinant Proteins for RTN4
- Browse Sino Biological Cell Lysates
-
Cloud-Clone Corp. Proteins for RTN4
- Search GeneTex for Proteins for RTN4
-
Abcam proteins for RTN4
Assay Products
-
Cloud-Clone Corp. Assay Kits for RTN4
No data available for DME Specific Peptides for RTN4 Gene
Domains & Families for RTN4 Gene
Gene Families for RTN4 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Suggested Antigen Peptide Sequences for RTN4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NQC3UniProtKB/Swiss-Prot:
RTN4_HUMAN :- Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane domains, known as Nogo-66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the spreading of neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity).
- Domain:
-
- Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane domains, known as Nogo-66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the spreading of neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity).
Function for RTN4 Gene
Molecular function for RTN4 Gene
- UniProtKB/Swiss-Prot Function:
- Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. Induces the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:25612671, PubMed:24262037, PubMed:27619977). Regulates membrane morphogenesis in the ER by promoting tubular ER production (PubMed:27619977). Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412).
Phenotypes From GWAS Catalog for RTN4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005515 | protein binding | IPI | 11126360 |
| GO:0031625 | ubiquitin protein ligase binding | IPI | 27353365 |
| GO:0045296 | cadherin binding | IDA | 25468996 |
Phenotypes for RTN4 Gene
- MGI mutant phenotypes for RTN4:
- inferred from 8 alleles
- GenomeRNAi human phenotypes for RTN4:
Animal Models for RTN4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RTN4
-
- Search ViGene Biosciences for RTN4
CRISPR Products
-
OriGene CRISPR knockouts for RTN4
- genomics-online: gRNA clones - Search results for available RTN4 gene related products
- Applied Biological Materials CRISPR for RTN4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RTN4
- GenScript: Design CRISPR guide RNA sequences for RTN4
miRNA for RTN4 Gene
- miRTarBase miRNAs that target RTN4
-
- hsa-mir-21-5p (MIRT000167)
- hsa-mir-16-5p (MIRT001421)
- hsa-mir-148b-3p (MIRT019491)
- hsa-mir-132-3p (MIRT021845)
- hsa-mir-183-5p (MIRT024991)
- hsa-mir-34a-5p (MIRT025475)
- hsa-mir-101-3p (MIRT027341)
- hsa-mir-33a-5p (MIRT028224)
- hsa-mir-320a (MIRT044751)
- hsa-mir-30c-5p (MIRT047850)
- hsa-mir-3148 (MIRT521269)
- hsa-mir-4330 (MIRT521270)
- hsa-mir-4496 (MIRT521271)
- hsa-mir-605-5p (MIRT521272)
- hsa-mir-4524b-5p (MIRT546625)
- hsa-mir-4524a-5p (MIRT546626)
- hsa-mir-1272 (MIRT546627)
- hsa-mir-646 (MIRT546628)
- hsa-mir-376c-3p (MIRT546629)
- hsa-mir-4643 (MIRT546630)
- hsa-mir-338-5p (MIRT546631)
- hsa-mir-4662b (MIRT546632)
- hsa-mir-4647 (MIRT546633)
- hsa-mir-4426 (MIRT546634)
- hsa-mir-497-5p (MIRT546635)
- hsa-mir-15b-5p (MIRT546636)
- hsa-mir-195-5p (MIRT546637)
- hsa-mir-6838-5p (MIRT546638)
- hsa-mir-424-5p (MIRT546639)
- hsa-mir-15a-5p (MIRT546640)
- hsa-mir-503-5p (MIRT546641)
miRNA Products
- Search ViGene Biosciences for RTN4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for RTN4
- Browse OriGene Inhibitory RNA Products For RTN4
- genomics-online: shRNA clones - Search results for available RTN4 gene related products
Clone Products
-
OriGene ORF clones in human for RTN4
- RG221136
- RC221136L2
- RC221136L1
- RC221136
- RG220981
- RC220981L2
- RC220981L1
- RC220981
- RG219796
- RC219796L2
- RC219796L1
- RC219796
- RG223470
- RC223470L2
- RC223470L1
- RC223470
- RG221080
- RC221080L2
- RC221080L1
- RC221080
- RC221136L2V
- RC221136L1V
- RC220981L2V
- RC220981L1V
- RC219796L2V
- RC219796L1V
- RC223470L2V
- RC223470L1V
- RC221080L2V
- RC221080L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RTN4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RTN4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RTN4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RTN4
- genomics-online: cdna clones - Search results for available RTN4 gene related products
- orf clones - Search results for available RTN4 gene related products
- Applied Biological Materials Clones for RTN4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for RTN4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RTN4 Gene
Localization for RTN4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RTN4 Gene
- Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Anchored to the membrane of the endoplasmic reticulum (ER) through 2 putative transmembrane domains. Localizes throughout the ER tubular network (PubMed:27619977). Co-localizes with TMEM33 at the ER sheets. {ECO:0000269 PubMed:25612671, ECO:0000269 PubMed:27619977}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| endoplasmic reticulum | 5 |
| cytoskeleton | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| golgi apparatus | 1 |
- Endoplasmic reticulum (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IMP | 14644040 |
| GO:0005635 | nuclear envelope | IDA | 11126360 |
| GO:0005783 | endoplasmic reticulum | IEA,NAS | 11126360 |
| GO:0005789 | endoplasmic reticulum membrane | IEA,IDA | 25612671 |
| GO:0005886 | plasma membrane | TAS | -- |
Pathways & Interactions for RTN4 Gene
Pathways by source for RTN4 Gene
1 Cell Signaling Technology pathway for RTN4 Gene
2 BioSystems pathways for RTN4 Gene
5 Reactome pathways for RTN4 Gene
1 KEGG pathway for RTN4 Gene
1 GeneGo (Thomson Reuters) pathway for RTN4 Gene
1 Qiagen pathway for RTN4 Gene
Interacting Proteins for RTN4 Gene
Selected Interacting proteins:
ENSP00000337838
Q9NQC3-RTN4_HUMAN
for RTN4 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | NAS | 11126360 |
| GO:0007399 | nervous system development | IEA | -- |
| GO:0007413 | axonal fasciculation | IBA,ISS | -- |
| GO:0010634 | positive regulation of epithelial cell migration | IMP | 27353365 |
| GO:0021801 | cerebral cortex radial glia guided migration | ISS | -- |
Transcripts for RTN4 Gene
mRNA/cDNA for RTN4 Gene
- (14) REFSEQ mRNAs :
- (49) Additional mRNA sequences :
- (1507) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for RTN4
- genomics-online: gRNA clones - Search results for available RTN4 gene related products
- Applied Biological Materials CRISPR for RTN4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RTN4
- GenScript: Design CRISPR guide RNA sequences for RTN4
miRNA Products
- Search ViGene Biosciences for RTN4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for RTN4
- Browse OriGene Inhibitory RNA Products For RTN4
- genomics-online: shRNA clones - Search results for available RTN4 gene related products
Clone Products
-
OriGene ORF clones in human for RTN4
- RG221136
- RC221136L2
- RC221136L1
- RC221136
- RG220981
- RC220981L2
- RC220981L1
- RC220981
- RG219796
- RC219796L2
- RC219796L1
- RC219796
- RG223470
- RC223470L2
- RC223470L1
- RC223470
- RG221080
- RC221080L2
- RC221080L1
- RC221080
- RC221136L2V
- RC221136L1V
- RC220981L2V
- RC220981L1V
- RC219796L2V
- RC219796L1V
- RC223470L2V
- RC223470L1V
- RC221080L2V
- RC221080L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RTN4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RTN4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RTN4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RTN4
- genomics-online: cdna clones - Search results for available RTN4 gene related products
- orf clones - Search results for available RTN4 gene related products
- Applied Biological Materials Clones for RTN4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c | · | 15d | ^ | 16 | ^ |
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| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
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| SP13: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: |
| ExUns: | 17a | · | 17b | · | 17c | · | 17d |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | |||||||
| SP3: | |||||||
| SP4: | |||||||
| SP5: | |||||||
| SP6: | |||||||
| SP7: | |||||||
| SP8: | |||||||
| SP9: | |||||||
| SP10: | |||||||
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| SP12: | |||||||
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| SP18: |
Expression for RTN4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Cerebellum
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Eye (Sensory Organs)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RTN4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of RTN4 Gene:
RTN4SOURCE GeneReport for Unigene cluster for RTN4 Gene:
Hs.637850mRNA Expression by UniProt/SwissProt for RTN4 Gene:
Q9NQC3-RTN4_HUMAN
Tissue specificity:
Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis-specific.
Evidence on tissue expression from TISSUES for RTN4 Gene
- Muscle(5)
- Nervous system(5)
- Liver(4.7)
- Blood(4.5)
- Skin(4.5)
- Eye(4.4)
- Kidney(4.3)
- Lung(4.3)
- Pancreas(4.1)
- Heart(2.8)
- Adrenal gland(2.6)
- Intestine(2.4)
- Bone(2.2)
- Gall bladder(2.1)
Primer Products
-
OriGene qPCR primer pairs for RTN4
-
OriGene qPCR primer pairs and template standards for RTN4
- genomics-online: primer clones - Search results for available RTN4 gene related products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTN4 Gene
Orthologs for RTN4 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RTN4 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | RTN4 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | RTN4 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Rtn4 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Rtn4 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RTN4 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | RTN4 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RTN4 34 |
|
OneToOne | |
| LOC101749579 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | RTN4 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rtn4 33 |
|
||
| Str.386 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68489 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | rtn4a 34 |
|
OneToOne | |
| Dr.24718 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8546 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Rtnl1 34 |
|
ManyToMany | |
| Rtnl2 34 |
|
ManyToMany | |||
| CG42853 34 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | ret-1 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RTN2 36 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10170 34 |
|
OneToMany |
- Species where no ortholog for RTN4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for RTN4 Gene
(6) SIMAP similar genes for RTN4 Gene using alignment to 10 proteins:
Variants for RTN4 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_035904 | A colorectal cancer sample | p.Leu429Val | |||
| rs1000037017 | -- | 54,975,267(-) | A/C | intron_variant | |
| rs1000041744 | -- | 55,118,021(-) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000052566 | -- | 55,081,909(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000064918 | -- | 55,035,168(-) | A/G | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2474783 | CNV | deletion | 19546169 |
| esv2517082 | CNV | deletion | 19546169 |
| esv2720078 | CNV | deletion | 23290073 |
| esv3340657 | CNV | insertion | 20981092 |
| nsv582029 | CNV | loss | 21841781 |
| nsv834069 | CNV | loss | 17160897 |
| nsv953127 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.11;
80.53% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RTN4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RTN4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTN4 Gene
Disorders for RTN4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| demyelinating disease |
|
|
| pedophilia |
|
|
| alzheimer disease |
|
|
| disease of mental health |
|
|
| amyotrophic lateral sclerosis 1 |
|
Search RTN4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RTN4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for RTN4 Gene
Publications for RTN4 Gene
- Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. (PMID: 10667797) GrandPré T … Strittmatter SM (Nature 2000) 2 3 4 22 58
- The association between dilated cardiomyopathy and RTN4 3'UTR insertion/deletion polymorphisms. (PMID: 18948092) Zhou B … Zhang L (Clinica chimica acta; international journal of clinical chemistry 2009) 3 22 44 58
- Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. (PMID: 16835300) Miao RQ … Sessa WC (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 22 58
- CAA insertion polymorphism in the 3'UTR of Nogo gene on 2p14 is not associated with schizophrenia. (PMID: 15661375) Xiong L … Joober R (Brain research. Molecular brain research 2005) 3 22 44 58
- Nogo CAA 3'UTR Insertion polymorphism is not associated with Schizophrenia nor with bipolar disorder. (PMID: 15820318) Gregório SP … Dias-Neto E (Schizophrenia research 2005) 3 22 44 58
Products for RTN4 Gene
- R&D Systems Antibodies for RTN4 (Nogo-A)
- R&D Systems Antibodies for RTN4 (Nogo-B)
- R&D Systems Antibodies for RTN4 (Nogo-C)
- R&D Systems Proteins and Enzymes for RTN4 (Nogo-A)
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for RTN4
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for RTN4
- Origene Custom Protein Services for RTN4
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RTN4
- Browse OriGene Inhibitory RNA Products For RTN4
- OriGene qPCR primer pairs and template standards for RTN4
- OriGene qPCR primer pairs for RTN4
- OriGene CRISPR knockouts for RTN4
- OriGene ORF clones in human for RTN4
- RC221080L1V
- RC221080L2V
- RC223470L1V
- RC223470L2V
- RC219796L1V
- RC219796L2V
- RC220981L1V
- RC220981L2V
- RC221136L1V
- RC221136L2V
- RC221080
- RC221080L1
- RC221080L2
- RG221080
- RC223470
- RC223470L1
- RC223470L2
- RG223470
- RC219796
- RC219796L1
- RC219796L2
- RG219796
- RC220981
- RC220981L1
- RC220981L2
- RG220981
- RC221136
- RC221136L1
- RC221136L2
- RG221136
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RTN4
- GenScript: Next-day shipping of latest version cDNA ORF clones for RTN4 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for RTN4
- GenScript Custom Assay Services for RTN4
- GenScript Custom overexpressing Cell Line Services for RTN4
- GenScript: Design CRISPR guide RNA sequences for RTN4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for RTN4
- Cell Signaling Technology (CST) Antibodies for RTN4 (Nogo)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for RTN4
- Sino Biological Recombinant Proteins for RTN4
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for RTN4
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for RTN4
- Novus Biologicals lysates and proteins for RTN4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam proteins for RTN4
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for RTN4
- Cloud-Clone Corp. Proteins for RTN4
- Cloud-Clone Corp. Assay Kits for RTN4
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for RTN4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for RTN4
- VectorBuilder custom plasmid, inducible vectors for RTN4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RTN4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RTN4
- antibodies-online: Search results for 156 available RTN4 Antibodies ranked by validation data
- Compare Top RTN4 Antibodies
- Recommended
- 101 WB Antibodies (anti-human)
- 15 IF (p) Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 80 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 82 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- antibodies-online: Search results for 17 available RTN4 Elisa Kits ranked by validation data
- Compare Top RTN4 Elisa Kits
- antibodies-online: Search results for 13 available RTN4 Proteins ranked by validation data
- Compare Top RTN4 Proteins
- GeneTex RTN4 antibody for RTN4
- Search GeneTex for Proteins for RTN4
- Search ViGene Biosciences for RTN4
- Santa Cruz Biotechnology (SCBT) Antibodies for RTN4
- Search Santa Cruz Biotechnology (SCBT) for RTN4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RTN4
- Custom Antibody ServicesProSci Antibodies for RTN4
- Search for RTN4 Proteins at ProSci
- Horizon Cell Lines for RTN4
- genomics-online: cdna clones - Search results for available RTN4 gene related products
- orf clones - Search results for available RTN4 gene related products
- genomics-online: gRNA clones - Search results for available RTN4 gene related products
- genomics-online: primer clones - Search results for available RTN4 gene related products
- genomics-online: shRNA clones - Search results for available RTN4 gene related products
Sources for RTN4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew