Aliases for RTN4 Gene
Aliases for RTN4 Gene
External Ids for RTN4 Gene
- HGNC: 14085
- Entrez Gene: 57142
- Ensembl: ENSG00000115310
- OMIM: 604475
- UniProtKB: Q9NQC3
Previous GeneCards Identifiers for RTN4 Gene
- GC02M055237
- GC02M055386
- GC02M055173
- GC02M055110
- GC02M055199
Summaries for RTN4 Gene
-
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for RTN4 Gene
RTN4 (Reticulon 4) is a Protein Coding gene. Diseases associated with RTN4 include Demyelinating Disease and Pedophilia. Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Spinal Cord Injury. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is RTN3.
UniProtKB/Swiss-Prot for RTN4 Gene
-
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. Induces the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:25612671, PubMed:24262037). Regulates membrane morphogenesis in the ER by promoting tubular ER production. Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTN4 Gene
Genomics for RTN4 Gene
Regulatory Elements for RTN4 Gene
Enhancers for RTN4 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH02G055002 | 1.4 | ENCODE dbSUPER | 38.8 | +108.4 | 108418 | 3.1 | PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF143 | RTN4 CLHC1 GC02M055015 GC02M054976 |
| GH02G054975 | 1.2 | Ensembl ENCODE dbSUPER | 44 | +135.6 | 135571 | 2.2 | PKNOX1 JUNB TBX21 POLR2A IKZF1 NBN TCF7 ETV6 RELB CREM | RTN4 EML6 GC02M054976 GC02M055015 |
| GH02G055005 | 1.3 | ENCODE dbSUPER | 40.1 | +102.7 | 102657 | 8.2 | HDGF HNRNPUL1 FOXA2 ATF1 ARNT MLX AGO1 ZFP64 SIN3A FEZF1 | RTN4 CLHC1 GC02M055015 GC02M054976 |
| GH02G055133 | 1.9 | FANTOM5 Ensembl ENCODE dbSUPER | 26.8 | -21.5 | -21530 | 2.1 | PKNOX1 ATF1 ARNT YY1 ZNF766 ELK1 KLF13 CAVIN1 JUNB REST | RTN4 CLHC1 RNU6-433P PPP4R3B CCDC88A GC02P055128 GC02M055160 |
| GH02G054954 | 1.5 | Ensembl ENCODE dbSUPER | 32.4 | +156.6 | 156636 | 2.3 | ATF1 YY1 TCF12 ZNF766 ELK1 GATA2 CAVIN1 TBX21 ZNF592 CREB3 | RTN4 CLHC1 GC02P054967 GC02P054931 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around RTN4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the RTN4 gene promoter:
Genomic Location for RTN4 Gene
- Chromosome:
- 2
- Start:
- 54,972,187 bp from pter
- End:
- 55,112,621 bp from pter
- Size:
- 140,435 bases
- Orientation:
- Minus strand
Genomic View for RTN4 Gene
Genes around RTN4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p16.1 by Ensembl
- 2p16.1 by Entrez Gene
- 2p16.1 by HGNC
RTN4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RTN4 Gene
Proteins for RTN4 Gene
-
Protein details for RTN4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NQC3-RTN4_HUMAN
- Recommended name:
- Reticulon-4
- Protein Accession:
- Q9NQC3
- O94962
- Q7L7Q5
- Q7L7Q6
- Q7L7Q8
- Q8IUA4
- Q96B16
- Q9BXG5
- Q9H212
- Q9H3I3
- Q9UQ42
- Q9Y293
- Q9Y2Y7
- Q9Y5U6
Protein attributes for RTN4 Gene
- Size:
- 1192 amino acids
- Molecular mass:
- 129931 Da
- Quaternary structure:
-
- Binds to RTN4R. Interacts with Bcl-xl and Bcl-2. Isoform 2 binds to NGBR and RTN3. Isoform 2 and isoform 3 interact with BACE1 and BACE2. Interacts with RTN4IP1. Interacts with ATL1. Interacts with TMEM170A (PubMed:26906412). Isoform 3 interacts with TMEM33 (PubMed:25612671).
- SequenceCaution:
-
- Sequence=AAD39920.1; Type=Frameshift; Positions=1149, 1156; Evidence={ECO:0000305}; Sequence=AAG43160.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAG43160.1; Type=Frameshift; Positions=684, 700; Evidence={ECO:0000305}; Sequence=BAA74909.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for RTN4 Gene
Post-translational modifications for RTN4 Gene
Other Protein References for RTN4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for RTN4 (Nogo-A)
- R&D Systems Antibodies for RTN4 (Nogo-B)
- R&D Systems Antibodies for RTN4 (Nogo-C)
- Cell Signaling Technology (CST) Antibodies for RTN4 (Nogo)
-
Custom Antibody ServicesOriGene Antibodies for RTN4
- Novus Biologicals Antibodies for RTN4
- Invitrogen Antibodies for RTN4
- antibodies-online Antibodies for RTN4: See all 149
- GeneTex RTN4 antibody for RTN4
-
Custom Antibody ServicesProSci Antibodies for RTN4
-
Santa Cruz Biotechnology (SCBT) Antibodies for RTN4
Protein Products
- R&D Systems Proteins and Enzymes for RTN4 (Nogo-A)
- Search Origene for MassSpec and Protein Over-expression Lysates for RTN4
- Origene Custom Protein Services for RTN4
- Sino Biological Recombinant Proteins for RTN4
- Browse Sino Biological Cell Lysates
- antibodies-online Proteins for RTN4: See all 12
- Search antibodies-online for peptides
- Search GeneTex for Proteins for RTN4
-
ProSci Proteins for RTN4
Assay Products
- antibodies-online Kits for RTN4: See all 12
No data available for DME Specific Peptides for RTN4 Gene
Domains & Families for RTN4 Gene
Suggested Antigen Peptide Sequences for RTN4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NQC3UniProtKB/Swiss-Prot:
RTN4_HUMAN :- Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane domains, known as Nogo-66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the spreading of neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity).
- Domain:
-
- Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane domains, known as Nogo-66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the spreading of neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity).
No data available for Gene Families for RTN4 Gene
Function for RTN4 Gene
Molecular function for RTN4 Gene
- UniProtKB/Swiss-Prot Function:
- Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. Induces the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:25612671, PubMed:24262037). Regulates membrane morphogenesis in the ER by promoting tubular ER production. Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IDA | 22658674 |
| GO:0005515 | protein binding | IPI | 11126360 |
| GO:0031625 | ubiquitin protein ligase binding | IPI | 27353365 |
| GO:0045296 | cadherin binding | IDA | 25468996 |
Phenotypes for RTN4 Gene
- MGI mutant phenotypes for RTN4:
- inferred from 8 alleles
- GenomeRNAi human phenotypes for RTN4:
Animal Models for RTN4 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for RTN4
- Cyagen custom Knockout/knockin (KOKI) mouse models for RTN4
-
- Search ViGene Biosciences for RTN4
CRISPR Products
-
OriGene CRISPR knockouts for RTN4
-
Santa Cruz Biotechnology (SCBT) CRISPR for RTN4
- GenScript: Design CRISPR guide RNA sequences for RTN4
miRNA for RTN4 Gene
- miRTarBase miRNAs that target RTN4
-
- hsa-mir-21-5p (MIRT000167)
- hsa-mir-16-5p (MIRT001421)
- hsa-mir-148b-3p (MIRT019491)
- hsa-mir-132-3p (MIRT021845)
- hsa-mir-183-5p (MIRT024991)
- hsa-mir-34a-5p (MIRT025475)
- hsa-mir-101-3p (MIRT027341)
- hsa-mir-33a-5p (MIRT028224)
- hsa-mir-320a (MIRT044751)
- hsa-mir-30c-5p (MIRT047850)
- hsa-mir-3148 (MIRT521269)
- hsa-mir-4330 (MIRT521270)
- hsa-mir-4496 (MIRT521271)
- hsa-mir-605-5p (MIRT521272)
- hsa-mir-4524b-5p (MIRT546625)
- hsa-mir-4524a-5p (MIRT546626)
- hsa-mir-1272 (MIRT546627)
- hsa-mir-646 (MIRT546628)
- hsa-mir-376c-3p (MIRT546629)
- hsa-mir-4643 (MIRT546630)
- hsa-mir-338-5p (MIRT546631)
- hsa-mir-4662b (MIRT546632)
- hsa-mir-4647 (MIRT546633)
- hsa-mir-4426 (MIRT546634)
- hsa-mir-497-5p (MIRT546635)
- hsa-mir-15b-5p (MIRT546636)
- hsa-mir-195-5p (MIRT546637)
- hsa-mir-6838-5p (MIRT546638)
- hsa-mir-424-5p (MIRT546639)
- hsa-mir-15a-5p (MIRT546640)
- hsa-mir-503-5p (MIRT546641)
miRNA Products
- Search ViGene Biosciences for RTN4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for RTN4
- Browse OriGene Inhibitory RNA Products For RTN4
Clone Products
-
OriGene ORF clones in human for RTN4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RTN4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for RTN4
- VectorBuilder custom plasmid, inducible vectors for RTN4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RTN4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for RTN4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RTN4 Gene
Localization for RTN4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RTN4 Gene
- Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains. Co-localizes with TMEM33 at the ER sheets. {ECO:0000269 PubMed:25612671}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| endoplasmic reticulum | 5 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IMP | 14644040 |
| GO:0005635 | nuclear envelope | IDA | 11126360 |
| GO:0005783 | endoplasmic reticulum | IEA,NAS | 11126360 |
| GO:0005789 | endoplasmic reticulum membrane | IDA,IEA | 25612671 |
| GO:0005886 | plasma membrane | TAS | -- |
Pathways & Interactions for RTN4 Gene
Pathways by source for RTN4 Gene
1 Cell Signaling Technology pathway for RTN4 Gene
2 BioSystems pathways for RTN4 Gene
5 Reactome pathways for RTN4 Gene
1 KEGG pathway for RTN4 Gene
1 GeneGo (Thomson Reuters) pathway for RTN4 Gene
1 Qiagen pathway for RTN4 Gene
Interacting Proteins for RTN4 Gene
Selected Interacting proteins:
ENSP00000337838
Q9NQC3-RTN4_HUMAN
for RTN4 Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | NAS | 11126360 |
| GO:0007399 | nervous system development | IEA | -- |
| GO:0007413 | axonal fasciculation | ISS | -- |
| GO:0010634 | positive regulation of epithelial cell migration | IMP | 27353365 |
| GO:0021801 | cerebral cortex radial glia guided migration | ISS | -- |
Transcripts for RTN4 Gene
mRNA/cDNA for RTN4 Gene
- (14) REFSEQ mRNAs :
- (49) Additional mRNA sequences :
- (1507) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for RTN4
-
Santa Cruz Biotechnology (SCBT) CRISPR for RTN4
- GenScript: Design CRISPR guide RNA sequences for RTN4
miRNA Products
- Search ViGene Biosciences for RTN4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for RTN4
- Browse OriGene Inhibitory RNA Products For RTN4
Clone Products
-
OriGene ORF clones in human for RTN4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RTN4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for RTN4
- VectorBuilder custom plasmid, inducible vectors for RTN4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RTN4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c | · | 15d | ^ | 16 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: |
| ExUns: | 17a | · | 17b | · | 17c | · | 17d |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | |||||||
| SP3: | |||||||
| SP4: | |||||||
| SP5: | |||||||
| SP6: | |||||||
| SP7: | |||||||
| SP8: | |||||||
| SP9: | |||||||
| SP10: | |||||||
| SP11: | |||||||
| SP12: | |||||||
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| SP18: |
Expression for RTN4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Cerebellum
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Eye (Sensory Organs)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RTN4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of RTN4 Gene:
RTN4SOURCE GeneReport for Unigene cluster for RTN4 Gene:
Hs.637850mRNA Expression by UniProt/SwissProt for RTN4 Gene:
Q9NQC3-RTN4_HUMAN
Tissue specificity:
Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis-specific.
Evidence on tissue expression from TISSUES for RTN4 Gene
- Muscle(5)
- Nervous system(5)
- Liver(4.7)
- Blood(4.5)
- Eye(4.4)
- Skin(4.4)
- Kidney(4.3)
- Lung(4.2)
- Pancreas(4.1)
- Heart(2.7)
- Adrenal gland(2.6)
- Intestine(2.4)
- Bone(2.2)
- Gall bladder(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for RTN4
-
OriGene qPCR primer pairs for RTN4
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTN4 Gene
Orthologs for RTN4 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RTN4 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | RTN4 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | RTN4 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Rtn4 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Rtn4 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RTN4 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | RTN4 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RTN4 35 |
|
OneToOne | |
| LOC101749579 34 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | RTN4 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rtn4 34 |
|
||
| Str.386 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68489 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | rtn4a 35 |
|
OneToOne | |
| Dr.24718 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8546 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Rtnl1 35 |
|
ManyToMany | |
| Rtnl2 35 |
|
ManyToMany | |||
| CG42853 35 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | ret-1 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RTN2 37 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10170 35 |
|
OneToMany |
- Species where no ortholog for RTN4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for RTN4 Gene
(6) SIMAP similar genes for RTN4 Gene using alignment to 10 proteins:
Variants for RTN4 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_035904 | A colorectal cancer sample | ||||
| rs1000037017 | -- | 54,975,267(+) | CTTTG(A/C)AGGAT | intron-variant | |
| rs1000041744 | -- | 55,118,021(+) | TGTTT(A/G)GGATT | intron-variant | |
| rs1000052566 | -- | 55,081,909(+) | CCTGC(C/T)TTTTT | intron-variant | |
| rs1000064918 | -- | 55,035,168(+) | CCACT(A/G)CCAAT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2474783 | CNV | deletion | 19546169 |
| esv2517082 | CNV | deletion | 19546169 |
| esv2720078 | CNV | deletion | 23290073 |
| esv3340657 | CNV | insertion | 20981092 |
| nsv582029 | CNV | loss | 21841781 |
| nsv834069 | CNV | loss | 17160897 |
| nsv953127 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.11;
80.53% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for RTN4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RTN4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTN4 Gene
Disorders for RTN4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| demyelinating disease |
|
|
| pedophilia |
|
|
| disease of mental health |
|
|
| specific developmental disorder |
|
|
| dependent personality disorder |
|
|
Search RTN4 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for RTN4
No data available for UniProtKB/Swiss-Prot and Genatlas for RTN4 Gene
Publications for RTN4 Gene
- Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. (PMID: 10667797) GrandPre T. … Strittmatter S.M. (Nature 2000) 2 3 4 22 64
- The association between dilated cardiomyopathy and RTN4 3'UTR insertion/deletion polymorphisms. (PMID: 18948092) Zhou B. … Zhang L. (Clin. Chim. Acta 2009) 3 22 46 64
- Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. (PMID: 16835300) Miao R.Q. … Sessa W.C. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 22 64
- Gender-specific association of insertion/deletion polymorphisms in the nogo gene and chronic schizophrenia. (PMID: 15953657) Tan E.C. … Teo Y.Y. (Brain Res. Mol. Brain Res. 2005) 3 22 46 64
- Nogo CAA 3'UTR Insertion polymorphism is not associated with Schizophrenia nor with bipolar disorder. (PMID: 15820318) GregA^rio S.P. … Dias-Neto E. (Schizophr. Res. 2005) 3 22 46 64
Products for RTN4 Gene
- R&D Systems Antibodies for RTN4 (Nogo-A)
- R&D Systems Antibodies for RTN4 (Nogo-B)
- R&D Systems Antibodies for RTN4 (Nogo-C)
- R&D Systems Proteins and Enzymes for RTN4 (Nogo-A)
- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for RTN4
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for RTN4
- Origene Custom Protein Services for RTN4
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for RTN4
- Browse OriGene Inhibitory RNA Products For RTN4
- OriGene qPCR primer pairs and template standards for RTN4
- OriGene qPCR primer pairs for RTN4
- OriGene CRISPR knockouts for RTN4
- OriGene ORF clones in human for RTN4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RTN4
- GenScript: Next-day shipping cDNA ORF clone for RTN4 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for RTN4
- GenScript Custom Assay Services for RTN4
- GenScript Custom overexpressing Cell Line Services for RTN4
- GenScript: Design CRISPR guide RNA sequences for RTN4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for RTN4
- Cell Signaling Technology (CST) Antibodies for RTN4 (Nogo)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for RTN4
- Sino Biological Recombinant Proteins for RTN4
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for RTN4
- Novus Biologicals proteins and lysates for RTN4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for RTN4
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for RTN4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for RTN4
- antibodies-online Antibodies for RTN4: See all 149
- antibodies-online Kits for RTN4: See all 12
- antibodies-online Proteins for RTN4: See all 12
- Search antibodies-online for peptides
- GeneTex RTN4 antibody for RTN4
- Search GeneTex for Proteins for RTN4
- Search ViGene Biosciences for RTN4
- Santa Cruz Biotechnology (SCBT) Antibodies for RTN4
- Search Santa Cruz Biotechnology (SCBT) for RTN4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RTN4
- Custom Antibody ServicesProSci Antibodies for RTN4
- ProSci Proteins for RTN4
- Horizon Cell Lines for RTN4
- Cyagen custom Knockout/knockin (KOKI) mouse models for RTN4
- VectorBuilder custom plasmid, inducible vectors for RTN4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RTN4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for RTN4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
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- (122) diseasecard
- (123) NIH Rare Diseases
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- (128) Genetics Home Reference
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- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer