Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RTN4 Gene

protein-coding   GIFtS: 68
GCID: GC02M055199

Reticulon 4

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Reticulon 41 2     RTN4-B12
NOGO2 3 5     RTN4-B22
Neurite Outgrowth Inhibitor2 3     RTN4-C2
Neuroendocrine-Specific Protein C Homolog2 3     foocen2
NSP2 3     Human NogoA2
ASY2     My043 Protein2
NI220/2502     Neurite Growth Inhibitor 2202
NOGO-A2     Reticulon 52
NOGOC2     reticulon-42
NSP-CL2     Foocen3
Nbla002712     KIAA08863
Nbla105452     RTN-x3
Nogo-B2     Reticulon-53
Nogo-C2     Neuroendocrine-Specific Protein3
RTN-X2     Nogo Protein3
RTN4-A2     

External Ids:    HGNC: 140851   Entrez Gene: 571422   Ensembl: ENSG000001153107   OMIM: 6044755   UniProtKB: Q9NQC33   

Export aliases for RTN4 gene to outside databases

Previous GC identifers: GC02M055237 GC02M055386 GC02M055173 GC02M055110 GC02M054934


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RTN4 Gene:
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic
reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The
product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the
central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from
differential splicing and differential promoter usage and encoding different isoforms have been identified.
(provided by RefSeq, Jul 2008)

GeneCards Summary for RTN4 Gene: 
RTN4 (reticulon 4) is a protein-coding gene. Diseases associated with RTN4 include pathological gambling, and ventricular septal defect, and among its related super-pathways are p75NTR regulates axonogenesis and Development MAG-dependent inhibition of neurite outgrowth. GO annotations related to this gene include protein binding. An important paralog of this gene is RTN3.

UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3
Function: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion
and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension
in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction
of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing
receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is
likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum,
after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein
processing

Gene Wiki entry for RTN4 (Reticulon 4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RTN4 gene promoter:
         POU2F1   POU2F1a   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 10): RTN4 promoter sequence
   Search SABiosciences Chromatin IP Primers for RTN4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RTN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.3   Ensembl cytogenetic band:  2p16.1   HGNC cytogenetic band: 2p14-p13

RTN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTN4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M055199:  view genomic region     (about GC identifiers)

Start:
55,199,325 bp from pter      End:
55,339,757 bp from pter
Size:
140,433 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3 (See protein sequence)
Recommended Name: Reticulon-4  
Size: 1192 amino acids; 129931 Da
Subunit: Binds to RTN4R. Interacts with Bcl-xl and Bcl-2. Isoform 2 binds to NGBR and RTN3. Isoform 2 and isoform
3 interact with BACE1 and BACE2. Interacts with RTN4IP1. Interacts with ATL1
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Anchored to the membrane
of the endoplasmic reticulum through 2 putative transmembrane domains
Sequence caution: Sequence=AAD39920.1; Type=Frameshift; Positions=1149, 1156; Sequence=AAG43160.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAG43160.1; Type=Frameshift; Positions=684, 700;
Sequence=BAA74909.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for RTN4:
2G31 (3D)        2JV5 (3D)    
Secondary accessions: O94962 Q7L7Q5 Q7L7Q6 Q7L7Q8 Q8IUA4 Q96B16 Q9BXG5 Q9H212 Q9H3I3 Q9UQ42
Q9Y293 Q9Y2Y7 Q9Y5U6
Alternative splicing: 6 isoforms:  Q9NQC3-1   Q9NQC3-2   Q9NQC3-3   Q9NQC3-4   Q9NQC3-5   Q9NQC3-6   

Explore the universe of human proteins at neXtProt for RTN4: NX_Q9NQC3

Explore proteomics data for RTN4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NQC3

  • RTN4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RTN4 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_008939.1  NP_065393.1  NP_722550.1  NP_997403.1  NP_997404.1  

    ENSEMBL proteins: 
     ENSP00000378107   ENSP00000384471   ENSP00000349944   ENSP00000337838   ENSP00000322147  
     ENSP00000350365   ENSP00000378109   ENSP00000385650   ENSP00000397808   ENSP00000411628  
     ENSP00000384825   ENSP00000346465  
    Reactome Protein details: Q9NQC3
    Human Recombinant Protein Products for RTN4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for RTN4 (Nogo-A)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for RTN4
    OriGene Protein Over-expression Lysate for RTN4
    OriGene MassSpec for RTN4 
    OriGene Custom Protein Services for RTN4
    GenScript Custom Purified and Recombinant Proteins Services for RTN4
    Novus Biologicals RTN4 Proteins
    Novus Biologicals RTN4 Lysates
    Sino Biological Recombinant Protein for RTN4
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RTN4 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IDA11126360
    GO:0005783endoplasmic reticulum NAS11126360
    GO:0005886plasma membrane TAS--
    GO:0030176integral to endoplasmic reticulum membrane IDA10667797
    GO:0042995cell projection IEA--

    RTN4 for ontologies           About GeneDecksing



    RTN4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RTN4
    R&D Systems Antibodies for RTN4 (Nogo-A, Nogo-B, Nogo-C)
    OriGene Antibodies for RTN4
    OriGene Custom Antibody Services for RTN4
    GenScript Custom Superior Antibodies Services for RTN4
    Novus Biologicals RTN4 Antibodies
    Abcam antibodies for RTN4
    Cloud-Clone Corp. Antibodies for RTN4 
    ThermoFisher Antibodies for RTN4
    LSBio Antibodies in human, mouse, rat for RTN4 

    Assay Products for RTN4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RTN4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RTN4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RTN4 
    Cloud-Clone Corp. CLIAs for RTN4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003388 Reticulon

    Graphical View of Domain Structure for InterPro Entry Q9NQC3

    ProtoNet protein and cluster: Q9NQC3

    1 Blocks protein domain: IPB003388 Reticulon

    UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3
    Domain: Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane
    domains, known as Nogo-66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the
    spreading of neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity)
    Similarity: Contains 1 reticulon domain


    RTN4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RTN4_HUMAN, Q9NQC3
    Function: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion
    and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension
    in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction
    of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing
    receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is
    likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum,
    after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein
    processing

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11126360
         
    RTN4 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Rtn4):
     cellular  mortality/aging  nervous system  normal 

    RTN4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RTN4: Rtn4tm1Schw Rtn4tm2.1Matl Rtn4tm2Matl

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RTN4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RTN4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RTN4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RTN4 

    miRNA
    Products:
        
    miRTarBase miRNAs that target RTN4:
    hsa-mir-16 (MIRT001421), hsa-mir-21 (MIRT000167)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RTN4
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RTN4 (see all 19):
    hsa-miR-4318 hsa-miR-15a hsa-miR-503 hsa-miR-3692 hsa-miR-424 hsa-miR-195 hsa-miR-497* hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidRTN4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RTN4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RTN4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RTN4
    Sirion Biotech Customized adenovirus for overexpression of RTN4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RTN4 (see all 32)
    OriGene ORF clones in mouse, rat for RTN4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): RTN4 (NM_020532)
    Sino Biological Human cDNA Clone for RTN4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RTN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTN4
    Sirion Biotech Customized lentivirus for stable overexpression of RTN4 
                         Customized lentivirus expression plasmids for stable overexpression of RTN4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RTN4
    Search LifeMap BioReagents cell lines for RTN4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RTN4 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Axonal growth inhibition (RHOA activation)
    Axonal growth inhibition (RHOA activation)0.90
    p75NTR regulates axonogenesis0.90
    2Development MAG-dependent inhibition of neurite outgrowth
    Development MAG-dependent inhibition of neurite outgrowth0.87
    3Cell death signalling via NRAGE, NRIF and NADE
    p75 NTR receptor-mediated signalling0.73
    4Signaling by FGFR
    Signalling by NGF0.71
    5Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RTN4
        Development MAG-dependent inhibition of neurite outgrowth

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RTN4
        NgR-p75(NTR)-Mediated Signaling

    1 GeneGo (Thomson Reuters) Pathway for RTN4
        Development MAG-dependent inhibition of neurite outgrowth

    2 BioSystems Pathways for RTN4
        Spinal Cord Injury
    p75(NTR)-mediated signaling


    5        Reactome Pathways for RTN4
        Axonal growth inhibition (RHOA activation)
    Signal Transduction
    p75NTR regulates axonogenesis
    Signalling by NGF
    p75 NTR receptor-mediated signalling



    RTN4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RTN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/67 Interacting proteins for RTN4 (Q9NQC31, 2, 3 ENSP000003378384) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000236693P044402, 3, ENSP000004141964MINT-8258153 I2D: score=2 STRING: ENSP00000414196
    ENSG00000237710P044402, 3, ENSP000003892884MINT-8258153 I2D: score=2 STRING: ENSP00000389288
    ENSG00000215048P044402, 3MINT-8258153 I2D: score=2 
    ENSG00000226826P044402, 3MINT-8258153 I2D: score=2 
    ENSG00000230763P044402, 3MINT-8258153 I2D: score=2 
    About this table

    Gene Ontology (GO): 16 biological process terms (GO ID links to tree view) (see first 5):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006915apoptotic process NAS11126360
    GO:0007399nervous system development ----
    GO:0007413axonal fasciculation ISS--
    GO:0021801cerebral cortex radial glia guided migration ISS--
    GO:0030308negative regulation of cell growth IMP--
    GO:0030334regulation of cell migration IDA15034570
    GO:0030517negative regulation of axon extension IDA10667797
    GO:0042981regulation of apoptotic process NAS11126360
    GO:0048011neurotrophin TRK receptor signaling pathway TAS--
    GO:0050770regulation of axonogenesis TAS--
    GO:0050771negative regulation of axonogenesis TAS--
    GO:0051960regulation of nervous system development ----
    GO:0060317cardiac epithelial to mesenchymal transition IEA--
    GO:0071786endoplasmic reticulum tubular network organization IMP18779370
    GO:2000172regulation of branching morphogenesis of a nerve ISS--

    RTN4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RTN4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RTN4

    1 Novoseek inferred chemical compound relationship for RTN4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ddvp 58 1 17029193 (1)

    Search CenterWatch for drugs/clinical trials and news about RTN4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RTN4 gene (5 alternative transcripts): 
    NM_007008.2  NM_020532.4  NM_153828.2  NM_207520.1  NM_207521.1  

    Unigene Cluster for RTN4:

    Reticulon 4
    Hs.637850  [show with all ESTs]
    Unigene Representative Sequence: NM_020532
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394609(uc002ryc.3) ENST00000405240 ENST00000357376(uc002ryd.3)
    ENST00000337526(uc002rye.3) ENST00000317610(uc002ryg.3) ENST00000357732(uc002ryf.3)
    ENST00000394611 ENST00000404909 ENST00000486085 ENST00000491592 ENST00000485749
    ENST00000438462 ENST00000427710 ENST00000461004 ENST00000402434 ENST00000354474


    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RTN4
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate RTN4 (see all 19):
    hsa-miR-4318 hsa-miR-15a hsa-miR-503 hsa-miR-3692 hsa-miR-424 hsa-miR-195 hsa-miR-497* hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidRTN4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RTN4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RTN4
    Clone
    Products:
         
    OriGene clones in human, mouse for RTN4 (see all 32)
    OriGene ORF clones in mouse, rat for RTN4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): RTN4 (NM_020532)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RTN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTN4
    Sirion Biotech Customized lentivirus for stable overexpression of RTN4 
                         Customized lentivirus expression plasmids for stable overexpression of RTN4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RTN4
    OriGene qSTAR qPCR primer pairs in human, mouse for RTN4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RTN4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RTN4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTN4

    Additional mRNA sequence: 

    AB015639.1 AB020693.1 AB040462.1 AB040463.1 AB073351.1 AB073359.1 AF063601.1 AF077050.1 
    AF087901.1 AF125103.1 AF132047.1 AF132048.1 AF148537.1 AF148538.1 AF177332.1 AF320999.1 
    AF333336.1 AJ251383.1 AJ251384.1 AJ251385.1 AK075039.1 AK098385.1 AK129806.1 AK130812.1 
    AK172726.1 AK302741.1 AY102276.1 AY102277.1 AY102278.1 AY102279.1 AY123245.1 AY123246.1 
    AY123247.1 AY123248.1 AY123249.1 AY123250.1 BC001035.2 BC007109.1 BC010737.1 BC012619.1 
    BC014366.1 BC016165.1 BC026788.1 BC068991.1 BC071848.1 BC150182.1 BC152425.1 BC152555.1 
    DQ778739.1 

    24/70 DOTS entries (see all 70):

    DT.87018236  DT.92057768  DT.91855184  DT.100039375  DT.97862663  DT.95148397  DT.100889622  DT.97776594 
    DT.100039374  DT.100889645  DT.100039372  DT.121021010  DT.100889631  DT.420660  DT.100889638  DT.100889649 
    DT.100889641  DT.100889621  DT.121021012  DT.408266  DT.95128616  DT.95329023  DT.100889636  DT.102838873 

    24/1507 AceView cDNA sequences (see all 1507):

    AA746210 AA370616 CB164794 AA192937 W19399 BF448757 BQ638521 AA331600 
    BF591729 CB162885 AJ251384 W73282 CB108617 BU729639 AU104978 AY123247 
    BU952509 W21129 CB133824 AI217084 BM709363 AA058672 W95807 AL533461 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for RTN4 (see all 18)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d ^ 16 ^
    SP1:        -     -     -     -     -     -     -     -     -     -                 -     -     -                       -           -     -                     
    SP2:                          -     -     -     -     -     -     -                 -     -     -                       -           -     -                     
    SP3:                                      -     -     -     -     -                 -     -     -                       -           -     -                     
    SP4:                                                  -     -     -                 -     -     -                       -           -     -                     
    SP5:                                                        -     -                 -     -     -                       -           -     -                     

    ExUns: 17a · 17b · 17c · 17d
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for RTN4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RTN4 expression in normal human tissues (normalized intensities)      RTN4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGCCACA
    RTN4 Expression
    About this image


    RTN4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 26 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             colon ; peripheral nerve/ganglion   
             spinal/ganglion/dorsal root ganglion   
     
     Colon (Gastrointestinal Tract)
             colon ; peripheral nerve/ganglion   
     
     Testis (Reproductive System)
             testis ; cells in seminiferus ducts   

    See RTN4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RTN4

    SOURCE GeneReport for Unigene cluster: Hs.637850

    UniProtKB/Swiss-Prot: RTN4_HUMAN, Q9NQC3
    Tissue specificity: Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal
    muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and
    adipocytes. Isoform 4 is testis-specific

        SABiosciences Expression via Pathway-Focused PCR Arrays including RTN4: 
              Neurogenesis in human mouse rat
              Nephrotoxicity in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RTN4
    OriGene qSTAR qPCR primer pairs in human, mouse for RTN4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RTN4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RTN4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTN4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RTN4 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rtn41 , 5 reticulon 41, 5 83.97(n)1
    78.32(a)1
      11 (16.79 cM)5
    685851  NM_194054.31  NP_918943.11 
     296929475 
    chicken
    (Gallus gallus)
    Aves RTN41 reticulon 4 65.24(n)
    54.37(a)
      378790  XM_003640893.1  XP_003640941.1 
    lizard
    (Anolis carolinensis)
    Reptilia RTN46
    Uncharacterized protein
    47(a)
    1 ↔ 1
    1(263834474-263901082)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684892 hypothetical protein MGC68489 78.12(n)    BC059960.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.247182 Transcribed sequence with weak similarity to protein more 74.33(n)    57038777 


    ENSEMBL Gene Tree for RTN4 (if available)
    TreeFam Gene Tree for RTN4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RTN4 gene
    RTN32  RTN12  RTN22  
    6 SIMAP similar genes for RTN4 using alignment to 10 protein entries:     RTN4_HUMAN (see all proteins):
    NOGOC    Nbla10545    Nbla00271    RTN3    RTN1    RTN2

    RTN4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2140 SNPs in RTN4 are shown (see all 2140)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359044
    A colorectal cancer sample4--see VAR_0359042 L V mis40--------
    rs1505009551,2
    C--55065245(+) CATGTC/TTGCCT 5 -- ds50010--------
    rs774080681,2
    C,F--55065324(+) CGATTA/GATGAT 5 -- ds50011Minor allele frequency- G:0.09WA 118
    rs787088271,2
    C,F--55065441(+) CTGCAC/GTGTAT 5 -- ds50011Minor allele frequency- G:0.01NA 120
    rs8871,2
    C,F,O,A,H--55065457(-) TTAACT/CCACAT 5 -- ds500135Minor allele frequency- C:0.23MN EA NA NS WA CSA 5199
    rs800983851,2
    C,F--55065479(+) ATGAAT/ATTATT 5 -- ds50011Minor allele frequency- A:0.06WA 118
    rs1910984871,2
    --55065501(+) AAACAC/TATCAC 5 -- ds50010--------
    rs38390541,2
    C--55065560(-) AACAA-/AAGTCAA 5 -- ds50010--------
    rs1832858611,2
    --55065573(+) CCACAA/GTAAAC 5 -- ds50010--------
    rs1388756101,2
    C--55065575(+) ACAGT-/AAAC  
            
    AAACA
    5 -- ds50010--------

    HapMap Linkage Disequilibrium report for RTN4 (55199325 - 55339757 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RTN4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2474783CNV Deletion19546169
    esv2517082CNV Deletion19546169
    esv2720078CNV Deletion23290073
    esv267485CNV Insertion20981092
    nsv834069CNV Loss17160897
    nsv874155CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RTN4
    DNA2.0 Custom Variant and Variant Library Synthesis for RTN4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604475    OMIM disorders: --

    20/32 diseases for RTN4 (see all 32):    About MalaCards
    pathological gambling    ventricular septal defect    cerebral artery occlusion    inclusion body myositis
    myositis    cerebrovascular accident    amyotrophic lateral sclerosis    lateral sclerosis
    cervical squamous cell carcinoma    oligodendroglioma    temporal lobe epilepsy    adult t-cell leukemia
    multiple sclerosis    schizophrenia    brain disease    dilated cardiomyopathy
    aortic aneurysm    bipolar disorder    t-cell leukemia    down syndrome

    3 diseases from the University of Copenhagen DISEASES database for RTN4:
    Amyotrophic lateral sclerosis     Multiple sclerosis     Cerebrovascular accident

    RTN4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/12 Novoseek inferred disease relationships for RTN4 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amyotrophic lateral sclerosis 60.8 15 15786457 (3), 18419791 (2), 12270696 (1), 19889996 (1) (see all 9)
    epilepsy temporal lobe 33.9 4 15619232 (1), 15245492 (1), 16772867 (1), 17439704 (1)
    neurodegenerative diseases 32.4 1 14644040 (1)
    schizophrenia 24.9 28 12425946 (5), 15234466 (4), 17022955 (3), 14741411 (2) (see all 8)
    scar 24 3 11597097 (1), 16646157 (1), 15566408 (1)
    multiple sclerosis 20.1 7 14644040 (2), 18495952 (2), 20437585 (1), 17356385 (1) (see all 5)
    small cell lung cancer 17.9 1 11494121 (1)
    tumors 5.29 6 17592524 (2), 12510146 (1), 11891768 (1), 18685489 (1)
    cancer 5.21 5 12510146 (2), 11494121 (2), 15781961 (1)
    neurological disorders 3.72 2 14644040 (2)

    Genetic Association Database (GAD): RTN4
    Human Genome Epidemiology (HuGE) Navigator: RTN4 (10 documents)

    Export disorders for RTN4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RTN4 gene, integrated from 9 sources (see all 218):
    (articles sorted by number of sources associating them with RTN4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. (PubMed id 10667797)1, 2, 3, 9 GrandPre T.... Strittmatter S.M. (2000)
    2. Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping. (PubMed id 10773680)1, 2, 3 Yang J.... Zhao S.-Y. (2000)
    3. Genomic structure and functional characterisation of the promoters of human and mouse nogo/rtn4. (PubMed id 12488097)1, 2, 9 Oertle T.... Schwab M.E. (2003)
    4. No association between the genetic polymorphisms within RTN4 and schizophrenia in the Chinese population. (PubMed id 15234466)1, 4, 9 Chen W....He L. (2004)
    5. Nogo CAA 3'UTR Insertion polymorphism is not associated with Schizophrenia nor with bipolar disorder. (PubMed id 15820318)1, 4, 9 Gregorio S.P....Dias-Neto E. (2005)
    6. Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration. (PubMed id 11891768)1, 2, 9 Ng C.E.L. and Tang B.L. (2002)
    7. Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. (PubMed id 16835300)1, 2, 9 Miao R.Q.... Sessa W.C. (2006)
    8. CAA insertion polymorphism in the 3'UTR of Nogo gene on 2p14 is not associated with schizophrenia. (PubMed id 15661375)1, 4, 9 Xiong L....Joober R. (2005)
    9. Nogo 3'-untranslated region CAA insertion: failure to replicate association with schizophrenia and demonstration of marked population difference in frequency of the insertion. (PubMed id 14741411)1, 4, 9 Covault J....Kranzler H. (2004)
    10. The association between dilated cardiomyopathy and RTN4 3'UTR insertion/deletion polymorphisms. (PubMed id 18948092)1, 4, 9 Zhou B....Zhang L. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57142 HGNC: 14085 AceView: RTN4 Ensembl:ENSG00000115310 euGenes: HUgn57142
    ECgene: RTN4 H-InvDB: RTN4

    (According to HUGE)
    About This Section
    HUGE: KIAA0886

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RTN4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RTN4 Genetics and Cytogenetics in Oncology and Haematology
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=R&genename=RTN4+%40+NOGO
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt069.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RTN4 gene:
    Search GeneIP for patents involving RTN4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of RTN4
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for RTN4 (Nogo-A)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for RTN4 (Nogo-A)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RTN4   OriGene RNAi products in human, mouse, rat for RTN4  
     OriGene qPCR primer pairs and template standards for RTN4   OriGene Protein Over-expression Lysate for RTN4  
     OriGene MassSpec something-or-other for RTN4   OriGene clones in human, mouse for RTN4  
     OriGene qSTAR qPCR primer pairs in human, mouse for RTN4   OriGene Purified Protein for RTN4  
     OriGene ORF clones in mouse, rat for RTN4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RTN4   OriGene Custom Protein Services for RTN4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RTN4
     QIAGEN SeqTarget long-range PCR primers for resequencing RTN4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RTN4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RTN4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTN4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RTN4
     GenScript Custom Purified and Recombinant Proteins Services for RTN4 GenScript cDNA clones with any tag delivered in your preferred vector for RTN4
     GenScript Custom Assay Services for RTN4 GenScript Custom Superior Antibodies Services for RTN4
     GenScript Custom overexpressing Cell Line Services for RTN4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RTN4 promoter
     Search Chromatin IP Primers for RTN4
     RT2 qPCR Primer Assay in human, mouse, rat RTN4
     GNC Network for RTN4
     SABiosciences PCR Arrays including human, mouse, rat RTN4
     Search Tocris compounds for RTN4
     Proteins and Antibodies for RTN4
     Browse Sino Biological Cell Lysates
     cDNA Clones for RTN4
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RTN4 antibodies
     RTN4 proteins
     RTN4 lysates
     Antibodies for RTN4
     See all of Abcam's Antibodies, Kits and Proteins for RTN4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for RTN4
     Antibodies for RTN4
     ELISAs for RTN4
     CLIAs for RTN4
     Search LifeMap BioReagents cell lines for RTN4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN4
     SwitchGear 3'UTR luciferase reporter plasmids for RTN4
     SwitchGear Promoter luciferase reporter plasmids for RTN4
     ThermoFisher Antibodies for RTN4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTN4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RTN4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RTN4
    Customized:
     lentivirus for stable overexpression of RTN4
     lentivirus expression plasmids for stable overexpression of RTN4
     adenovirus for overexpression of RTN4
     LSBio Antibodies in human, mouse, rat for RTN4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RTN4 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4