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RTN3 Gene

protein-coding   GIFtS: 57
GCID: GC11P063448

Reticulon 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Reticulon 31 2     ASYIP2 3
NSP-Like Protein II1 2 3     HAP2 3
Homolog Of ASY Protein1 2 3     NSPLII2 3
Neuroendocrine-Specific Protein-Like 21 2 3     NSP-Like Protein 22 3
NSPL22 3 5     Isoforme III1
ASY Interacting Protein1 2     RTN3-A12
Neuroendocrine-Specific Protein-Like II2 3     reticulon-32

External Ids:    HGNC: 104691   Entrez Gene: 103132   Ensembl: ENSG000001333187   OMIM: 6042495   UniProtKB: O951973   

Export aliases for RTN3 gene to outside databases

Previous GC identifers: GC11P065970 GC11P065024 GC11P063700 GC11P063224 GC11P063205 GC11P059778


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RTN3 Gene:
This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in
neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid
converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon
protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative
modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been
found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. (provided by RefSeq, May
2012)

GeneCards Summary for RTN3 Gene:
RTN3 (reticulon 3) is a protein-coding gene. An important paralog of this gene is RTN4.

UniProtKB/Swiss-Prot: RTN3_HUMAN, O95197
Function: May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and
amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to
the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in
the viral replication or pathogenesis

Gene Wiki entry for RTN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the RTN3 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   E2F-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRTN3 promoter sequence
   Search Chromatin IP Primers for RTN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RTN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

RTN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTN3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P063448:  view genomic region     (about GC identifiers)

Start:
63,448,918 bp from pter      End:
63,527,363 bp from pter
Size:
78,446 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RTN3_HUMAN, O95197 (See protein sequence)
Recommended Name: Reticulon-3  
Size: 1032 amino acids; 112611 Da
Subunit: Homodimer. Interacts with ATL1 (By similarity). Interacts with RTN4. Isoform 3 interacts with BACE1,
BACE2, BCL2 and FADD. Interacts with Coxsackievirus A16, enterovirus 71 and poliovirus P2C proteins. Interacts
with ATL2
Sequence caution: Sequence=BAD93008.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KQS2 B7Z308 B7Z4M0 F5H774 Q147U9 Q496K2 Q53GN3 Q59EP0 Q5UEP2 Q6T930
Q7RTM7 Q7RTM8 Q7RTN3
Alternative splicing: 7 isoforms:  O95197-1   O95197-2   O95197-3   O95197-4   O95197-5   O95197-6   O95197-7   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for RTN3: NX_O95197

Explore proteomics data for RTN3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys998, Lys1018
  • Modification sites at PhosphoSitePlus

  • See RTN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001252518.1  NP_001252519.1  NP_001252520.1  NP_006045.1  NP_958831.1  NP_958832.1  NP_958833.1  

    ENSEMBL proteins: 
     ENSP00000340903   ENSP00000437971   ENSP00000367050   ENSP00000344106   ENSP00000442733  
     ENSP00000441614   ENSP00000442080   ENSP00000440960   ENSP00000440874   ENSP00000346492  
     ENSP00000348279  

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    Cloud-Clone Corp. Proteins for RTN3

     
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    antibodies-online proteins for RTN3 (4 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003388 Reticulon

    Graphical View of Domain Structure for InterPro Entry O95197

    ProtoNet protein and cluster: O95197

    1 Blocks protein domain: IPB003388 Reticulon

    UniProtKB/Swiss-Prot: RTN3_HUMAN, O95197
    Similarity: Contains 1 reticulon domain


    Find genes that share domains with RTN3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RTN3_HUMAN, O95197
    Function: May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and
    amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to
    the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in
    the viral replication or pathogenesis
    Induction: By endoplasmic reticulum stress (at protein level)

         Genatlas biochemistry entry for RTN3:
    reticulon 3,neuroendocrine protein,associated with the endoplasmic reticulum,expressed in neural
    tissues,particularly in the macular region of the retina

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with RTN3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RTN3:
     Decreased melanin production  Synthetic lethal with c-Myc af 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RTN3

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    miRTarBase miRNAs that target RTN3:
    hsa-mir-378a-3p (MIRT043942), hsa-mir-484 (MIRT041723), hsa-mir-106a-5p (MIRT048346), hsa-mir-760 (MIRT036707), hsa-mir-155-5p (MIRT020529), hsa-mir-17-5p (MIRT050976)

    Block miRNA regulation of human, mouse, rat RTN3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RTN3 (see all 31):
    hsa-miR-21* hsa-miR-498 hsa-miR-100* hsa-miR-3673 hsa-miR-548k hsa-miR-4263 hsa-miR-486-3p hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidRTN3 3' UTR sequence
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    Sino Biological Human cDNA Clone for RTN3
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    Addgene plasmids for RTN3 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RTN3_HUMAN, O95197: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane;
    Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus5
    extracellular4
    plasma membrane3
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005615extracellular space TAS10331947
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with RTN3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RTN3
    Interactions:

        GeneGlobe Interaction Network for RTN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RTN3 (O951972, 3 ENSP000003441064) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8202163 I2D: score=1 STRING: ENSP00000250416
    COL4A3BPQ9Y5P43, ENSP000003698624I2D: score=4 STRING: ENSP00000369862
    FAM160A2Q8N6123, ENSP000002659784I2D: score=4 STRING: ENSP00000265978
    FXR2P511163, ENSP000002501134I2D: score=4 STRING: ENSP00000250113
    PLEKHF2Q9H8W43, ENSP000003223734I2D: score=4 STRING: ENSP00000322373
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0006950response to stress IEA--
    GO:0016032viral process IEA--
    GO:0016192vesicle-mediated transport IEA--
    GO:0019048modulation by virus of host morphology or physiology ----

    Find genes that share ontologies with RTN3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for RTN3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RTN3 gene (7 alternative transcripts): 
    NM_001265589.1  NM_001265590.1  NM_001265591.1  NM_006054.3  NM_201428.2  NM_201429.2  NM_201430.2  

    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341307(uc001nxp.3 uc010rmt.2) ENST00000542238 ENST00000538995
    ENST00000377819(uc001nxq.3) ENST00000339997(uc001nxn.3 uc009yov.3)
    ENST00000540798 ENST00000545432 ENST00000543552 ENST00000543123 ENST00000536011
    ENST00000537981 ENST00000338850 ENST00000354497 ENST00000356000(uc001nxm.3 uc001nxo.3 uc010rmu.2)

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    Selected qRT-PCR Assays for microRNAs that regulate RTN3 (see all 31):
    hsa-miR-21* hsa-miR-498 hsa-miR-100* hsa-miR-3673 hsa-miR-548k hsa-miR-4263 hsa-miR-486-3p hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidRTN3 3' UTR sequence
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    Selected AceView cDNA sequences (see all 1066):

    CR614599 AA633802 AI354787 BM969152 BM014809 AI074677 AA486966 AI278189 
    BM754529 AI921228 BX383705 BQ223929 BC022993 BX445914 BM976897 NM_006054 
    BQ883455 BP362310 BM739641 AI569961 BP360599 BQ889111 BG697882 AW262923 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RTN3 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:                          -     -     -     -     -     -     -     -     -                                   -                                             
    SP2:                          -     -     -     -     -     -     -     -     -                                   -                       -                     
    SP3:                                -     -     -     -     -     -     -     -                                   -                                             
    SP4:                                -     -     -     -     -     -     -     -     -                                                                           
    SP5:                                -     -     -     -     -     -     -                                                                                       


    ECgene alternative splicing isoforms for RTN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RTN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTAGTAGG
    RTN3 Expression
    About this image


    RTN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Eye (Sensory Organs)
             Retina
     
     Colon (Gastrointestinal Tract)
    RTN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RTN3 Protein Expression

    UniProtKB/Swiss-Prot: RTN3_HUMAN, O95197
    Tissue specificity: Isoform 3 is widely expressed, with highest levels in brain, where it is enriched in neuronal
    cell bodies from gray matter (at protein level). Three times more abundant in macula than in peripheral retina.
    Isoform 1 is expressed at high levels in brain and at low levels in skeletal muscle. Isoform 2 is only found in
    melanoma

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RTN3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rtn31 , 5 reticulon 31, 5 80.43(n)1
    71.95(a)1
      19 (5.32 cM)5
    201681  NM_001003934.21  NP_001003934.11 
     74259015 
    lizard
    (Anolis carolinensis)
    Reptilia RTN36
    reticulon 3
    39(a)
    1 ↔ 1
    GL343890.1(89575-128828)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.190532 Xenopus laevis transcribed sequence with weak similarity more 71.6(n)    CD303290.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc564392 similar to reticulon 3 71.93(n)   394047  BC062828.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rtnl26
    Rtnl16
    (see all 3)
    Rtnl1
    (see all 3)
    26(a)
    24(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    3R(3354586-3355963)
    2L(4992808-5009720)
    worm
    (Caenorhabditis elegans)
    Secernentea ret-16
    Protein RET-1, isoform c
    6(a)
    1 → many
    V(14829177-14847312) WBGene00004336


    ENSEMBL Gene Tree for RTN3 (if available)
    TreeFam Gene Tree for RTN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RTN3 gene
    RTN42  RTN12  RTN22  
    3 SIMAP similar genes for RTN3 using alignment to 6 protein entries:     RTN3_HUMAN (see all proteins):
    NOGOC    RTN1    RTN4

    Find genes that share paralogs with RTN3           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for RTN3
    PGOHUM00000258642 PGOHUM00000246096


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RTN3 (see all 1575)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476912561,2
    --63446968(+) AGAGCG/TTTTAA 9 -- us2k10--------
    rs1829390171,2
    --63447007(+) AACAGC/TTCCCC 9 -- us2k10--------
    rs5287701,2
    F--63447040(-) CGTGCA/GTATGT 9 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1868622631,2
    --63447044(+) ATGCAC/TGTATC 9 -- us2k10--------
    rs1423926811,2
    --63447067(+) TAACTA/GGCTTG 9 -- us2k10--------
    rs1901157611,2
    --63447135(+) CAGCTC/GATGCA 9 -- us2k10--------
    rs795134471,2
    F--63447200(+) ATGCCT/CTTTTC 9 -- us2k11Minor allele frequency- C:0.04WA 118
    rs71246231,2
    H--63447209(+) TCAGAG/CCATTG 9 -- us2k14Minor allele frequency- C:0.00NS EA 418
    rs5020171,2
    C,F,H--63447230(-) GAGGAT/GGACTC 9 -- us2k19Minor allele frequency- G:0.02NS EA NA WA 1208
    rs122936931,2
    F--63447506(+) ttgacG/Agagat 9 -- us2k11Minor allele frequency- A:0.05WA 118

    HapMap Linkage Disequilibrium report for RTN3 (63448918 - 63527363 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RTN3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673702CNV Deletion23128226
    nsv832183CNV Loss17160897
    nsv825940CNV Loss20364138
    nsv897628CNV Gain21882294

    Human Gene Mutation Database (HGMD): RTN3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RTN3
    DNA2.0 Custom Variant and Variant Library Synthesis for RTN3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604249    OMIM disorders: --


    Find genes that share disorders with RTN3           About GenesLikeMe

    Genetic Association Database (GAD): RTN3
    Human Genome Epidemiology (HuGE) Navigator: RTN3 (3 documents)

    Export disorders for RTN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RTN3 gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with RTN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel member of the reticulon gene family (RTN3): gene structure and chromosomal localization to 11q13. (PubMed id 10331947)1, 2, 3, 9 Moreira E.F.... Rodriguez I.R. (Genomics 1999)
    2. Identification of a new RTN3 transcript, RTN3-A1, and its distribution in adult mouse brain. (PubMed id 15946766)1, 2, 9 Cai Y.... Yu L. (Brain Res. Mol. Brain Res. 2005)
    3. Reticulon 3 mediates Bcl-2 accumulation in mitochondria in response to endoplasmic reticulum stress. (PubMed id 17191123)1, 2, 9 Wan Q.... Liu Y. (Apoptosis 2007)
    4. Pro-apoptotic ASY/Nogo-B protein associates with ASYIP. (PubMed id 12811824)1, 2, 9 Qi B.... Yutsudo M. (J. Cell. Physiol. 2003)
    5. Tissue specificity and regulation of the N-terminal diversity of reticulon 3. (PubMed id 15350194)1, 2, 9 Di Scala F.... Loeffler J.-P. (Biochem. J. 2005)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Variation in RTN3 and PPIL2 genes does not influence platelet membrane beta-secretase activity or susceptibility to alzheimer's disease in the northern Irish population. (PubMed id 19669607)1, 4 Carson R....Johnston J.A. (Neuromolecular Med. 2009)
    8. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    9. Reticulon 3 binds the 2C protein of enterovirus 71 and is required for viral replication. (PubMed id 17182608)1, 2 Tang W.-F.... Horng J.-T. (J. Biol. Chem. 2007)
    10. The membrane topology of RTN3 and its effect on binding of RTN3 to BACE1. (PubMed id 17699523)1, 2 He W.... Yan R. (J. Biol. Chem. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10313 HGNC: 10469 AceView: RTN3 Ensembl:ENSG00000133318 euGenes: HUgn10313
    ECgene: RTN3 H-InvDB: RTN3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RTN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RTN3 gene:
    Search GeneIP for patents involving RTN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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