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Aliases for RTN3 Gene

Aliases for RTN3 Gene

  • Reticulon 3 2 3
  • Neuroendocrine-Specific Protein-Like 2 2 3 4
  • Homolog Of ASY Protein 2 3 4
  • NSP-Like Protein II 2 3 4
  • Neuroendocrine-Specific Protein-Like II 3 4
  • ASY Interacting Protein 2 3
  • NSP-Like Protein 2 3 4
  • NSPLII 3 4
  • ASYIP 3 4
  • NSPL2 3 4
  • HAP 3 4
  • Isoforme III 2
  • RTN3-A1 3

External Ids for RTN3 Gene

Previous GeneCards Identifiers for RTN3 Gene

  • GC11P065970
  • GC11P065024
  • GC11P063224
  • GC11P063205
  • GC11P063448
  • GC11P059778

Summaries for RTN3 Gene

Entrez Gene Summary for RTN3 Gene

  • This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012]

GeneCards Summary for RTN3 Gene

RTN3 (Reticulon 3) is a Protein Coding gene. An important paralog of this gene is RTN1.

UniProtKB/Swiss-Prot for RTN3 Gene

  • May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis.

Gene Wiki entry for RTN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTN3 Gene

Genomics for RTN3 Gene

Regulatory Elements for RTN3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RTN3 Gene

Chromosome:
11
Start:
63,681,360 bp from pter
End:
63,759,891 bp from pter
Size:
78,532 bases
Orientation:
Plus strand

Genomic View for RTN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RTN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTN3 Gene

Proteins for RTN3 Gene

  • Protein details for RTN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95197-RTN3_HUMAN
    Recommended name:
    Reticulon-3
    Protein Accession:
    O95197
    Secondary Accessions:
    • B3KQS2
    • B7Z308
    • B7Z4M0
    • F5H774
    • Q147U9
    • Q496K2
    • Q53GN3
    • Q59EP0
    • Q5UEP2
    • Q6T930
    • Q7RTM7
    • Q7RTM8
    • Q7RTN3

    Protein attributes for RTN3 Gene

    Size:
    1032 amino acids
    Molecular mass:
    112611 Da
    Quaternary structure:
    • Homodimer. Interacts with ATL1 (By similarity). Interacts with RTN4. Isoform 3 interacts with BACE1, BACE2, BCL2 and FADD. Interacts with Coxsackievirus A16, enterovirus 71 and poliovirus P2C proteins. Interacts with ATL2.
    SequenceCaution:
    • Sequence=BAD93008.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RTN3 Gene

neXtProt entry for RTN3 Gene

Proteomics data for RTN3 Gene at MOPED

Post-translational modifications for RTN3 Gene

  • Ubiquitination at Lys 998 and Lys 1018
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RTN3 Gene

Domains & Families for RTN3 Gene

Protein Domains for RTN3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O95197

UniProtKB/Swiss-Prot:

RTN3_HUMAN :
  • Contains 1 reticulon domain.
Domain:
  • Contains 1 reticulon domain.
genes like me logo Genes that share domains with RTN3: view

No data available for Gene Families for RTN3 Gene

Function for RTN3 Gene

Molecular function for RTN3 Gene

GENATLAS Biochemistry:
reticulon 3,neuroendocrine protein,associated with the endoplasmic reticulum,expressed in neural tissues,particularly in the macular region of the retina
UniProtKB/Swiss-Prot Function:
May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis.
UniProtKB/Swiss-Prot Induction:
By endoplasmic reticulum stress (at protein level).

Gene Ontology (GO) - Molecular Function for RTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with RTN3: view
genes like me logo Genes that share phenotypes with RTN3: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RTN3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RTN3 Gene

Localization for RTN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTN3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RTN3 Gene COMPARTMENTS Subcellular localization image for RTN3 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
golgi apparatus 5

Gene Ontology (GO) - Cellular Components for RTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005615 extracellular space TAS 10331947
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0012505 endomembrane system IBA --
genes like me logo Genes that share ontologies with RTN3: view

Pathways & Interactions for RTN3 Gene

SuperPathways for RTN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0016032 viral process IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0071786 endoplasmic reticulum tubular network organization IMP 18779370
genes like me logo Genes that share ontologies with RTN3: view

No data available for Pathways by source and SIGNOR curated interactions for RTN3 Gene

Drugs & Compounds for RTN3 Gene

No Compound Related Data Available

Transcripts for RTN3 Gene

Unigene Clusters for RTN3 Gene

Reticulon 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RTN3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTN3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - -
SP6:
SP7: - - -
SP8:
SP9: - - - -
SP10: - -
SP11: - - -

Relevant External Links for RTN3 Gene

GeneLoc Exon Structure for
RTN3
ECgene alternative splicing isoforms for
RTN3

Expression for RTN3 Gene

mRNA expression in normal human tissues for RTN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RTN3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.7) and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for RTN3 Gene

This gene is overexpressed in Nasal epithelium (20.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RTN3 Gene



SOURCE GeneReport for Unigene cluster for RTN3 Gene Hs.743229

mRNA Expression by UniProt/SwissProt for RTN3 Gene

O95197-RTN3_HUMAN
Tissue specificity: Isoform 3 is widely expressed, with highest levels in brain, where it is enriched in neuronal cell bodies from gray matter (at protein level). Three times more abundant in macula than in peripheral retina. Isoform 1 is expressed at high levels in brain and at low levels in skeletal muscle. Isoform 2 is only found in melanoma.
genes like me logo Genes that share expression patterns with RTN3: view

Protein tissue co-expression partners for RTN3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for RTN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RTN3 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Rtn3 35
  • 80.43 (n)
  • 71.95 (a)
Rtn3 16
Rtn3 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RTN3 35
  • 99.34 (n)
  • 99.01 (a)
RTN3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rtn3 35
  • 78.72 (n)
  • 68.24 (a)
cow
(Bos Taurus)
Mammalia RTN3 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RTN3 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RTN3 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RTN3 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RTN3 36
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1940 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.19053 35
zebrafish
(Danio rerio)
Actinopterygii zgc56439 35
rtn3 36
  • 65 (a)
OneToMany
rtn3 36
  • 65 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG42853 36
  • 16 (a)
ManyToMany
Rtnl1 36
  • 24 (a)
ManyToMany
Rtnl2 36
  • 26 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ret-1 36
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10170 36
  • 29 (a)
OneToMany
Species with no ortholog for RTN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RTN3 Gene

ENSEMBL:
Gene Tree for RTN3 (if available)
TreeFam:
Gene Tree for RTN3 (if available)

Paralogs for RTN3 Gene

Paralogs for RTN3 Gene

(3) SIMAP similar genes for RTN3 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for RTN3 Gene

genes like me logo Genes that share paralogs with RTN3: view

Variants for RTN3 Gene

Sequence variations from dbSNP and Humsavar for RTN3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs8343 -- 63,758,764(-) CACCT(A/G)TAAGT utr-variant-3-prime, nc-transcript-variant
rs11954 -- 63,758,868(+) AGTGA(A/C)CGCCA utr-variant-3-prime, nc-transcript-variant
rs13335 -- 63,758,656(-) AAAAA(A/C)CCAAG utr-variant-3-prime, nc-transcript-variant
rs471288 -- 63,725,443(-) aaagg(A/G)aaaaa intron-variant
rs474548 -- 63,716,104(+) GTACA(A/G)AGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RTN3 Gene

Variant ID Type Subtype PubMed ID
nsv832183 CNV Loss 17160897
esv2673702 CNV Deletion 23128226
nsv897628 CNV Gain 21882294
nsv825940 CNV Loss 20364138

Variation tolerance for RTN3 Gene

Residual Variation Intolerance Score: 6.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.21; 69.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RTN3 Gene

HapMap Linkage Disequilibrium report
RTN3
Human Gene Mutation Database (HGMD)
RTN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTN3 Gene

Disorders for RTN3 Gene

Relevant External Links for RTN3

Genetic Association Database (GAD)
RTN3
Human Genome Epidemiology (HuGE) Navigator
RTN3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RTN3
genes like me logo Genes that share disorders with RTN3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RTN3 Gene

Publications for RTN3 Gene

  1. Cloning of a novel member of the reticulon gene family (RTN3): gene structure and chromosomal localization to 11q13. (PMID: 10331947) Moreira E.F. … Rodriguez I.R. (Genomics 1999) 2 23 67
  2. Reticulon 3 mediates Bcl-2 accumulation in mitochondria in response to endoplasmic reticulum stress. (PMID: 17191123) Wan Q. … Liu Y. (Apoptosis 2007) 23 67
  3. Selectively oncolytic mutant of HSV-1 lyses HeLa cells mediated by Ras/RTN3. (PMID: 17218780) Su Y. … Qi Y. (Cancer Biol. Ther. 2007) 23 67
  4. Tissue specificity and regulation of the N-terminal diversity of reticulon 3. (PMID: 15350194) Di Scala F. … Loeffler J.-P. (Biochem. J. 2005) 23 67
  5. ER Ca2+ depletion triggers apoptotic signals for endoplasmic reticulum (ER) overload response induced by overexpressed reticulon 3 (RTN3/HAP). (PMID: 15799019) Kuang E. … Qi Y. (J. Cell. Physiol. 2005) 23 67

Products for RTN3 Gene

Sources for RTN3 Gene

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