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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RTN3 Gene

protein-coding GIFtS: 53
GCID: GC11P063448

reticulon 3

Explore 7 diseases affiliated with
RTN3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Reticulon 3¹ ²		Neuroendocrine-Specific Protein-Like II² ³
NSPL2¹ ² ³ ⁵		NSP-Like Protein 2² ³
ASYIP¹ ² ³		NSP-Like Protein II² ³
NSPLII¹ ² ³		ASY Interacting Protein²
HAP¹ ²		Homolog Of ASY Protein²
RTN3-A1¹ ²		Reticulon-3¹
Neuroendocrine-Specific Protein-Like 2² ³

External Ids:	HGNC: 10469¹	Entrez Gene: 10313²	Ensembl: ENSG00000133318⁷	OMIM: 604249⁵	UniProtKB: O95197³

Export aliases for RTN3 gene to outside databases

Previous GC identifers: GC11P065970 GC11P065024 GC11P063700 GC11P063224 GC11P063205 GC11P059778

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RTN3:

This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine

tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1),

and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the

production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells.

Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes

of this gene are located on chromosomes 4 and 12. (provided by RefSeq, May 2012)

UniProtKB/Swiss-Prot: RTN3_HUMAN, O95197

Function: May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid

precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the

mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral

replication or pathogenesis

Gene Wiki entry for RTN3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RTN3 gene promoter:
E2F-4 E2F-3a E2F-5 E2F-1 E2F E2F-2 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RTN3 promoter sequence

Search SABiosciences Chromatin IP Primers for RTN3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RTN3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13

RTN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTN3 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P063448: view genomic region (about GC identifiers)

Start:	63,448,918 bp from pter	End:	63,527,363 bp from pter
Size:	78,446 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RTN3_HUMAN, O95197 (See protein sequence)

Recommended Name: Reticulon-3

Size: 1032 amino acids; 112611 Da

Subunit: Homodimer. Interacts with ATL1 (By similarity). Interacts with RTN4. Isoform 3 interacts with BACE1, BACE2,

BCL2 and FADD. Interacts with Coxsackievirus A16, enterovirus 71 and poliovirus P2C proteins. Interacts with ATL2

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass

membrane protein

Sequence caution: Sequence=BAD93008.1; Type=Erroneous initiation;

Secondary accessions: B3KQS2 B7Z308 B7Z4M0 Q147U9 Q496K2 Q53GN3 Q59EP0 Q5UEP2 Q6T930 Q7RTM7 Q7RTM8

Q7RTN3

Alternative splicing: 6 isoforms: O95197-1 O95197-2 O95197-3 O95197-4 O95197-5 O95197-6 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RTN3: NX_O95197

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O95197

RTN3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (7 alternative transcripts):

NP_001252518.1 NP_001252519.1 NP_001252520.1 NP_006045.1 NP_958831.1 NP_958832.1 NP_958833.1

ENSEMBL proteins:

ENSP00000340903 ENSP00000437971 ENSP00000367050 ENSP00000344106 ENSP00000442733

ENSP00000441614 ENSP00000442080 ENSP00000440960 ENSP00000440874 ENSP00000346492

ENSP00000348279

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	Uscn Proteins for RTN3

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005615	extracellular space	TAS	10331947
GO:0005783	endoplasmic reticulum	IDA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

RTN3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RTN3 for domains About GeneDecksing

1 InterPro domain/family:

IPR003388 Reticulon

Graphical View of Domain Structure for InterPro Entry O95197

ProtoNet protein and cluster: O95197

1 Blocks protein family: IPB003388 Reticulon

UniProtKB/Swiss-Prot: RTN3_HUMAN, O95197

Similarity: Contains 1 reticulon domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RTN3_HUMAN, O95197

Function: May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid

precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the

mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral

replication or pathogenesis

Induction: By endoplasmic reticulum stress (at protein level)

Genatlas biochemistry entry for RTN3:

reticulon 3,neuroendocrine protein,associated with the endoplasmic reticulum,expressed in neural tissues,particularly

in the macular region of the retina

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		hsa-miR-21* hsa-miR-498 hsa-miR-100* hsa-miR-3673 hsa-miR-548k hsa-miR-4263 hsa-miR-486-3p hsa-miR-371-5p

		SwitchGear 3'UTR luciferase reporter plasmid: RTN3 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN3

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

RTN3 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for RTN3:

Decreased melanin production

Synthetic lethal with c-Myc af

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RTN3

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/19 Interacting proteins for RTN3 (O95197^{2, 3} ENSP00000344106⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PARP2	Q9UGN5²^,³, ENSP00000250416⁴	MINT-8202163 I2D: score=1 STRING: ENSP00000250416
COL4A3BP	Q9Y5P4³, ENSP00000369862⁴	I2D: score=4 STRING: ENSP00000369862
FAM160A2	Q8N612³, ENSP00000265978⁴	I2D: score=4 STRING: ENSP00000265978
FXR2	P51116³, ENSP00000250113⁴	I2D: score=4 STRING: ENSP00000250113
PLEKHF2	Q9H8W4³, ENSP00000322373⁴	I2D: score=4 STRING: ENSP00000322373

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	IEA	--
GO:0006950	response to stress	IEA	--
GO:0016192	vesicle-mediated transport	IEA	--
GO:0019048	virus-host interaction	IEA	--
GO:0044419	interspecies interaction between organisms	--	--

RTN3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RTN3
Search CenterWatch for drugs/clinical trials and news about RTN3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RTN3 gene (7 alternative transcripts):

NM_001265589.1 NM_001265590.1 NM_001265591.1 NM_006054.3 NM_201428.2 NM_201429.2 NM_201430.2

Unigene Cluster for RTN3:

Reticulon 3

Hs.743229 [show with all ESTs]

Unigene Representative Sequence: NM_001265589

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000341307(uc001nxp.3 uc010rmt.2) ENST00000542238 ENST00000538995

ENST00000377819(uc001nxq.3) ENST00000339997(uc001nxn.3 uc009yov.3)

ENST00000540798 ENST00000545432 ENST00000543552 ENST00000543123 ENST00000536011

ENST00000537981 ENST00000338850 ENST00000354497 ENST00000356000(uc001nxm.3 uc001nxo.3 uc010rmu.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 4): RTN3 Browse OriGene MicroRNA Expression Plasmids
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		8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate RTN3 (see all 31):
		hsa-miR-21* hsa-miR-498 hsa-miR-100* hsa-miR-3673 hsa-miR-548k hsa-miR-4263 hsa-miR-486-3p hsa-miR-371-5p

		SwitchGear 3'UTR luciferase reporter plasmid: RTN3 3' UTR sequence

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Additional cDNA sequence:

AB209771.1 AF059524.1 AF119297.1 AK075412.1 AK094965.1 AK122727.1 AK127079.1 AK222898.1

AK295361.1 AK295534.1 AK295758.1 AK297529.1 AK297533.1 AK304100.1 AK307811.1 AK308083.1

AK309766.1 AY427821.2 AY750848.1 BC000634.1 BC000865.1 BC010556.1 BC011394.1 BC022993.1

BC100822.2 BC100823.2 BC105981.1 BC105982.1 BC118550.1 BC118628.1 NR_049750.1 NR_049751.1

24/53 DOTS entries (see all 53):

DT.100883331 DT.75184280 DT.92462910 DT.100883341 DT.100883358 DT.100883338 DT.95292332 DT.100693321

DT.91819941 DT.95120380 DT.97784696 DT.120740995 DT.100883330 DT.100683473 DT.100883336 DT.120741096

DT.100883351 DT.100883357 DT.120740964 DT.95336087 DT.95120437 DT.95120441 DT.100677020 DT.120741012

24/1066 AceView cDNA sequences (see all 1066):

CA396609 AV718158 BM450258 AI077446 BE049370 CN483761 BM264445 AI382917

BM983059 CA442974 AA812238 AA855102 CR619650 BM785625 AA772860 AW262923

BU148681 BQ722174 BM836745 BQ637719 CR606090 BQ049179 CF134642 CR609229

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for RTN3 (see all 11) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	·	4c	·	4d	·	4e	·	4f	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b	·	8c	^	9	^	10	^	11a	·	11b	·	11c
SP1:									-		-		-		-		-		-		-		-		-												-
SP2:									-		-		-		-		-		-		-		-		-												-								-
SP3:											-		-		-		-		-		-		-		-												-
SP4:											-		-		-		-		-		-		-		-		-
SP5:											-		-		-		-		-		-		-

ECgene alternative splicing isoforms for RTN3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RTN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCTAGTAGG

About this image

RTN3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Spinal Neural Tube Cells

Neural Ectoderm

Eye

Retina

Eye

Spinal Cord

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RTN3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RTN3

SOURCE GeneReport for Unigene cluster: Hs.743229

UniProtKB/Swiss-Prot: RTN3_HUMAN, O95197

Tissue specificity: Isoform 3 is widely expressed, with highest levels in brain, where it is enriched in neuronal cell

bodies from gray matter (at protein level). Three times more abundant in macula than in peripheral retina. Isoform 1

is expressed at high levels in brain and at low levels in skeletal muscle. Isoform 2 is only found in melanoma

SABiosciences Custom PCR Arrays for RTN3

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RTN3 gene from 4/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	RTN3⁶	--	44(a)	1 ↔ 1	GL343890.1(110055-124699)
African clawed frog (Xenopus laevis)	Amphibia	Xl.19053²	Xenopus laevis transcribed sequence with weak similarity more	71.6(n)		CD303290.1
zebrafish (Danio rerio)	Actinopterygii	zgc56439²	similar to reticulon 3	71.93(n)		394047 BC062828.1
fruit fly (Drosophila melanogaster)	Insecta	Rtnl2⁶ Rtnl1⁶ (see all 3)	Rtnl1 (see all 3)	25(a) 20(a) (see all 3)	possible ortholog 1 ↔ many (see all 3)	3R(3354586-3355963) 2L(4992808-5009720)

ENSEMBL Gene Tree for RTN3 (if available)
TreeFam Gene Tree for RTN3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RTN3 gene

RTN1² RTN4² RTN2²

5 SIMAP similar genes for RTN3 using alignment to 7 protein entries: RTN3_HUMAN (see all proteins):

NOGOC RTN1 RTN4 RTN2 Nbla00271

RTN3 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for RTN3
PGOHUM00000258642 PGOHUM00000246096

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147691256^1,2		--	63446968(+)	`AGAGCG/TTTTAA`	9	--	us2k¹		0	--	--	--	--
rs182939017^1,2		--	63447007(+)	`AACAGC/TTCCCC`	9	--	us2k¹		0	--	--	--	--
rs528770^1,2	F,	--	63447040(-)	`CGTGCA/GTATGT`	9	--	us2k¹		1		WA	118
rs186862263^1,2		--	63447044(+)	`ATGCAC/TGTATC`	9	--	us2k¹		0	--	--	--	--
rs142392681^1,2		--	63447067(+)	`TAACTA/GGCTTG`	9	--	us2k¹		0	--	--	--	--
rs190115761^1,2		--	63447135(+)	`CAGCTC/GATGCA`	9	--	us2k¹		0	--	--	--	--
rs79513447^1,2	F,	--	63447200(+)	`ATGCCT/CTTTTC`	9	--	us2k¹		1		WA	118
rs7124623^1,2	H	--	63447209(+)	`TCAGAG/CCATTG`	9	--	us2k¹		4		NS EA	418
rs502017^1,2	C,F,H,	--	63447230(-)	`GAGGAT/GGACTC`	9	--	us2k¹		9		NS EA NA WA	1208
rs12293693^1,2	F,	--	63447506(+)	`ttgacG/Agagat`	9	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for RTN3 (63448918 - 63527363 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RTN3: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RTN3 for disorders           About GeneDecksing

OMIM gene information: 604249    OMIM disorders: --

7 diseases for RTN3:    About MalaCards

neuroepithelioma alzheimer's disease astrocytoma atherosclerosis

thyroiditis melanoma neuronitis

Human Genome Epidemiology (HuGE) Navigator: RTN3 (3 documents)

Export disorders for RTN3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RTN3 gene, integrated from 9 sources (see all 57):
(articles sorted by number of sources associating them with RTN3)

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Cloning of a novel member of the reticulon gene family (RTN3): gene structure and chromosomal localization to 11q13. (PubMed id 10331947)^{1, 2, 3, 9} Moreira E.F.... Rodriguez I.R. (1999)
Identification of a new RTN3 transcript, RTN3-A1, and its distribution in adult mouse brain. (PubMed id 15946766)^{1, 2, 9} Cai Y.... Yu L. (2005)
Reticulon 3 mediates Bcl-2 accumulation in mitochondria in response to endoplasmic reticulum stress. (PubMed id 17191123)^{1, 2, 9} Wan Q.... Liu Y. (2007)
Pro-apoptotic ASY/Nogo-B protein associates with ASYIP. (PubMed id 12811824)^{1, 2, 9} Qi B.... Yutsudo M. (2003)
Tissue specificity and regulation of the N-terminal diversity of reticulon 3. (PubMed id 15350194)^{1, 2, 9} Di Scala F.... Loeffler J.-P. (2005)
Reticulon 3 binds the 2C protein of enterovirus 71 and is required for viral replication. (PubMed id 17182608)^{1, 2} Tang W.-F.... Horng J.-T. (2007)
Mapping of interaction domains mediating binding between BACE1 and RTN/Nogo proteins. (PubMed id 16979658)^{1, 2} He W.... Yan R. (2006)
Adaptor FADD is recruited by RTN3/HAP in ER-bound signaling complexes. (PubMed id 17031492)^{1, 2} Xiang R.... Qi Y. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein. (PubMed id 16965550)^{1, 2} Murayama K.S.... Araki W. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10313	HGNC: 10469	AceView: RTN3	Ensembl:ENSG00000133318	euGenes: HUgn10313
ECgene: RTN3	H-InvDB: RTN3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RTN3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RTN3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RTN3 gene:
Search GeneIP for patents involving RTN3

GeneCards and IP:
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