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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RTN2 Gene

protein-coding   GIFtS: 58
GCID: GC19M045988

Reticulon 2

(Previous name: spastic paraplegia 12 (autosomal dominant))
(Previous symbol: SPG12)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Reticulon 21 2     NSPLI2 3
NSP-Like Protein 11 2 3     NSP-Like Protein I2 3
NSPL12 3 5     Spastic Paraplegia 12 (Autosomal Dominant)1
SPG121 2     NSP22
Neuroendocrine-Specific Protein-Like 11 3     reticulon-22
Neuroendocrine-Specific Protein-Like I2 3     

External Ids:    HGNC: 104681   Entrez Gene: 62532   Ensembl: ENSG000001257447   OMIM: 6031835   UniProtKB: O752983   

Export aliases for RTN2 gene to outside databases

Previous GC identifers: GC19M046631 GC19M046379 GC19M050663 GC19M050680 GC19M042419


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RTN2 Gene:
This gene belongs to the family of reticulon encoding genes. Reticulons are necessary for proper generation of
tubular endoplasmic reticulum and likely play a role in intracellular vesicular transport. Alternatively spliced
transcript variants encoding different isoforms have been identified. Mutations at this locus have been
associated with autosomal dominant spastic paraplegia-12. (provided by RefSeq, Apr 2012)

GeneCards Summary for RTN2 Gene: 
RTN2 (reticulon 2) is a protein-coding gene. Diseases associated with RTN2 include spastic paraplegia 12, and paraplegia. GO annotations related to this gene include protein binding and signal transducer activity. An important paralog of this gene is RTN3.

Gene Wiki entry for RTN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RTN2 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRTN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RTN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RTN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.2-q13.3

RTN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTN2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M045988:  view genomic region     (about GC identifiers)

Start:
45,988,547 bp from pter      End:
46,000,319 bp from pter
Size:
11,773 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RTN2_HUMAN, O75298 (See protein sequence)
Recommended Name: Reticulon-2  
Size: 545 amino acids; 59264 Da
Subunit: Interacts with isoform 1 but not isoform 3 of SPAST
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential)
Secondary accessions: O60509 Q7RTM6 Q7RTN1 Q7RTN2
Alternative splicing, Alternative initiation: 3 isoforms:  O75298-1   O75298-2   O75298-3   (Produced by alternative initiation at Met-341 of isoform RTN2-A)

Explore the universe of human proteins at neXtProt for RTN2: NX_O75298

Explore proteomics data for RTN2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75298

  • RTN2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RTN2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_005610.1  NP_996783.1  NP_996784.1  

    ENSEMBL proteins: 
     ENSP00000245923   ENSP00000398178   ENSP00000468144   ENSP00000466619   ENSP00000345127  
     ENSP00000467863  

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    Cloud-Clone Corp. Proteins for RTN2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0030176integral to endoplasmic reticulum membrane NAS9693037

    RTN2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003388 Reticulon

    Graphical View of Domain Structure for InterPro Entry O75298

    ProtoNet protein and cluster: O75298

    1 Blocks protein domain: IPB003388 Reticulon

    UniProtKB/Swiss-Prot: RTN2_HUMAN, O75298
    Similarity: Contains 1 reticulon domain


    RTN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for RTN2:
    reticulon 2 neuroendocrine specific protein-like sequence 1,with two alternative spliced forms RTN2A,RTN2B and a
    truncated RTN2C form,highly expressed in skeletal muscle

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity NAS--
    GO:0005515protein binding IPI--
         
    RTN2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RTN2:
     Decreased p24 protein expressi  Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rtn2):
     homeostasis/metabolism  muscle 

    RTN2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rtn2tm1Lex for RTN2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RTN2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RTN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RTN2 
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    SwitchGear 3'UTR luciferase reporter plasmidRTN2 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RTN2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for RTN2 (O752983 ENSP000002459234) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FANCGO152873, ENSP000003679104I2D: score=1 STRING: ENSP00000367910
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction NAS--
    GO:0008219cell death IEA--

    RTN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RTN2

    Search CenterWatch for drugs/clinical trials and news about RTN2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RTN2 gene (4 alternative transcripts): 
    NM_005619.4  NM_206900.2  NM_206901.2  NM_206902.1  

    Unigene Cluster for RTN2:

    Reticulon 2
    Hs.47517  [show with all ESTs]
    Unigene Representative Sequence: NM_005619
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000245923(uc002pcb.3) ENST00000430715 ENST00000587597 ENST00000590526
    ENST00000344680(uc002pcc.3 uc002pcd.3) ENST00000591286 ENST00000588036
    ENST00000593187 ENST00000590746 ENST00000593129 ENST00000591789 ENST00000589628
    ENST00000592064 ENST00000589384

    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate RTN2 (see all 15):
    hsa-miR-3690 hsa-miR-566 hsa-miR-605 hsa-miR-519c-3p hsa-miR-519a hsa-miR-3692 hsa-miR-519b-3p hsa-miR-214
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    Additional mRNA sequence: 

    AF004222.1 AF004223.1 AF004224.1 AF038540.1 AK291967.1 AK314158.1 BC014244.2 BC073874.1 

    8 DOTS entries:

    DT.443768  DT.121420775  DT.100779580  DT.100779588  DT.100779586  DT.100807198  DT.103485  DT.95170984 

    24/165 AceView cDNA sequences (see all 165):

    BQ011380 BK001687 BE550126 NM_005619 BM988274 BI754303 BC014244 CR612056 
    AF004223 BU732182 CB852178 BQ671465 BK001689 BM704297 NM_206902 NM_206901 
    AI915284 BQ064611 BK001686 BE552025 BM716204 AA436800 AF004224 T08686 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RTN2 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
    SP1:              -     -                             -                       -                 -                       -                     
    SP2:              -                                   -                       -                 -                       -                     
    SP3:              -     -                                   -     -           -                 -                       -                     
    SP4:              -     -                             -     -     -           -                 -                       -                     
    SP5:              -     -                             -                       -                 -     -                 -                     


    ECgene alternative splicing isoforms for RTN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RTN2 expression in normal human tissues (normalized intensities)      RTN2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCCCAGGG
    RTN2 Expression
    About this image


    RTN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
             ganglion/cranial   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Eye (Sensory Organs)
             Retina

    See RTN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RTN2

    SOURCE GeneReport for Unigene cluster: Hs.47517

    UniProtKB/Swiss-Prot: RTN2_HUMAN, O75298
    Tissue specificity: Isoform RTN2-C is highly expressed in skeletal muscle

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RTN2 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rtn21 , 5 reticulon 2 (Z-band associated protein)1, 5 84.54(n)1
    85.47(a)1
      7 (9.54 cM)5
    201671  NM_013648.51  NP_038676.11 
     192826675 
    lizard
    (Anolis carolinensis)
    Reptilia RTN26
    Uncharacterized protein
    65(a)
    1 ↔ 1
    AAWZ02036043(4602-13828)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.136452 Transcribed sequence with weak similarity to protein more 71.35(n)    BX724945.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rtn2a6
    rtn2b6
    reticulon 2b
    41(a)
    33(a)
    many → 1
    many → 1
    15(9146207-9167312)
    21(20202152-20213995)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG428536
    Rtnl26
    Rtnl2
    20(a)
    20(a)
    many → 1
    many → 1
    3L(18114032-18115089)
    3R(3354586-3355963)


    ENSEMBL Gene Tree for RTN2 (if available)
    TreeFam Gene Tree for RTN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RTN2 gene
    RTN32  RTN42  RTN12  
    3 SIMAP similar genes for RTN2 using alignment to 6 protein entries:     RTN2_HUMAN (see all proteins):
    RTN1    NOGOC    RTN4

    RTN2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/346 SNPs in RTN2 are shown (see all 346)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs664846301,2
    C--45989970(+) TGTTC-/TTTTTT 3 -- int11Minor allele frequency- T:0.00NA 2
    rs1464947391,2
    C--45993793(+) GTGTC-/TGTGTGT 3 -- int10--------
    rs562791321,2
    C--45993828(+) TGTGTGTGT/-  
            
    TTTGT
    3 -- int11Minor allele frequency- -:0.00NA 2
    rs1996187651,2
    C--45994150(+) TTTTT-/TGAGAC 3 -- int10--------
    rs1121989591,2
    C,F--45994770(+) TGAGCT/CGCCAT 3 -- int14Minor allele frequency- C:0.11WA NA EA 244
    rs2005961501,2
    --46177745(+) TTCTT-/TCTTTTT 3 -- ds50010--------
    rs730499491,2
    C--46177746(+) TCTTTC/TTTTTT 3 -- ds50010--------
    rs1137030111,2
    C--46177746(+) TTTTTT/-GAGAC 3 -- ds50011Minor allele frequency- -:0.00CSA 2
    rs1470358971,2
    C--46177746(+) TCTTT-/CTTTTT 3 -- ds50010--------
    rs1825311501,2
    --46177782(+) CTGTCA/GCCGAG 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for RTN2 (45988547 - 46000319 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RTN2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv912156CNV Loss21882294
    dgv3953n71CNV Loss21882294
    nsv833848CNV Loss17160897
    nsv912154CNV Loss21882294
    nsv912155CNV Loss21882294


    Human Gene Mutation Database (HGMD): RTN2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RTN2
    DNA2.0 Custom Variant and Variant Library Synthesis for RTN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603183    OMIM disorders: --

    UniProtKB/Swiss-Prot: RTN2_HUMAN, O75298
  • Spastic paraplegia 12, autosomal dominant (SPG12) [MIM:604805]: A form of spastic paraplegia, a
    neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower
    limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include
    difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking.
    In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness
    may spread to other parts of the body. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 7 diseases for RTN2:    About MalaCards
    spastic paraplegia 12    paraplegia    spasticity    hereditary spastic paraplegia
    fanconi's anemia    anemia    neuronitis

    1 disease from the University of Copenhagen DISEASES database for RTN2:
    Paraplegia

    RTN2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): RTN2
    Human Genome Epidemiology (HuGE) Navigator: RTN2 (1 document)

    Export disorders for RTN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RTN2 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with RTN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel mouse gene with predominant muscle and neural expression. (PubMed id 9530622)1, 2, 3, 9 Geisler J.G.... Mucenski M.L. (1998)
    2. Mutations in the ER-shaping protein reticulon 2 cause the axon- degenerative disorder hereditary spastic paraplegia type 12. (PubMed id 22232211)1, 2, 3 Montenegro G....Zuchner S. (2012)
    3. cDNA cloning, genomic organization, and expression of the human RTN2 gene, a member of a gene family encoding reticulons. (PubMed id 9693037)1, 2, 9 Roebroek A.J.M.... Van de Ven W.J.M. (1998)
    4. A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family. (PubMed id 12832288)1, 2 Oertle T.... Schwab M.E. (2003)
    5. Detailed comparative map of human chromosome 19q and related regions of the mouse genome. (PubMed id 8812484)1, 3 Stubbs L....Ashworth L.K. (1996)
    6. Nspl1, a new Z-band-associated protein. (PubMed id 10672514)1, 9 Geisler J.G....Mucenski M.L. (1999)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Genetic associations of variants in genes encoding HI V-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (2010)
    9. Functional role of neuroendocrine-specific protein-li ke 1 in membrane translocation of GLUT4. (PubMed id 19720795)1 Ikemoto T....Endo M. (2009)
    10. Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1. (PubMed id 18096700)1 Liu Y....Rothstein J.D. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6253 HGNC: 10468 AceView: RTN2 Ensembl:ENSG00000125744 euGenes: HUgn6253
    ECgene: RTN2 H-InvDB: RTN2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RTN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RTN2 gene:
    Search GeneIP for patents involving RTN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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