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Aliases for RTN2 Gene

Aliases for RTN2 Gene

  • Reticulon 2 2 3 5
  • NSP-Like Protein 1 2 3 4
  • Neuroendocrine-Specific Protein-Like 1 2 4
  • Neuroendocrine-Specific Protein-Like I 3 4
  • NSP-Like Protein I 3 4
  • NSPL1 3 4
  • NSPLI 3 4
  • Spastic Paraplegia 12 (Autosomal Dominant) 2
  • Reticulon-2 3
  • SPG12 3
  • NSP2 3

External Ids for RTN2 Gene

Previous HGNC Symbols for RTN2 Gene

  • SPG12

Previous GeneCards Identifiers for RTN2 Gene

  • GC19M046631
  • GC19M046379
  • GC19M050663
  • GC19M050680
  • GC19M045988
  • GC19M042419

Summaries for RTN2 Gene

Entrez Gene Summary for RTN2 Gene

  • This gene belongs to the family of reticulon encoding genes. Reticulons are necessary for proper generation of tubular endoplasmic reticulum and likely play a role in intracellular vesicular transport. Alternatively spliced transcript variants encoding different isoforms have been identified. Mutations at this locus have been associated with autosomal dominant spastic paraplegia-12. [provided by RefSeq, Apr 2012]

GeneCards Summary for RTN2 Gene

RTN2 (Reticulon 2) is a Protein Coding gene. Diseases associated with RTN2 include Spastic Paraplegia 12, Autosomal Dominant and Spastic Paraplegia 12. An important paralog of this gene is RTN1.

Gene Wiki entry for RTN2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTN2 Gene

Genomics for RTN2 Gene

Regulatory Elements for RTN2 Gene

Enhancers for RTN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F045438 1.9 FANTOM5 Ensembl ENCODE 18.5 +51.2 51183 14.2 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 MEF2D ZNF610 CD3EAP ERCC1 RTN2 CCDC61 RELB PPM1N FBXO46 ZNF180 IGFL4 LOC105372421
GH19F045401 1.5 FANTOM5 ENCODE 11.9 +92.5 92489 6.2 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 YY1 ZNF207 ZNF180 CD3EAP ENSG00000259605 CCDC61 ENSG00000267395 ERCC1 ENSG00000268810 EXOC3L2 RPS16P9 ENSG00000267614
GH19F045567 1.2 Ensembl ENCODE 11.6 -72.1 -72130 2.4 PKNOX1 INSM2 KLF17 SIN3A FEZF1 ZNF48 ZBTB40 RAD21 ZEB1 ZNF121 OPA3 VASP RTN2 PPM1N EML2 MIR330 MIR642A ERCC1 CD3EAP PPP1R13L
GH19F045466 1.1 ENCODE 11.9 +28.0 27965 4.3 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF143 ZNF416 ZNF207 FOS ZNF180 CCDC61 FBXO46 CD3EAP ENSG00000266958 IGFL4 RPS16P9 ENSG00000267614 ENSG00000269148 ENSG00000268810
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RTN2 on UCSC Golden Path with GeneCards custom track

Promoters for RTN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000217015 61 1601 HDGF ZFP64 ARID4B SIN3A ZNF2 SLC30A9 ZNF143 ZNF548 SP3 MXD4

Genomic Location for RTN2 Gene

45,485,288 bp from pter
45,497,061 bp from pter
11,774 bases
Minus strand

Genomic View for RTN2 Gene

Genes around RTN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTN2 Gene

Proteins for RTN2 Gene

  • Protein details for RTN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O60509
    • Q7RTM6
    • Q7RTN1
    • Q7RTN2

    Protein attributes for RTN2 Gene

    545 amino acids
    Molecular mass:
    59264 Da
    Quaternary structure:
    • Interacts with isoform 1 but not isoform 3 of SPAST (PubMed:22232211). Isoform RTN2-B interacts with TMEM33 (PubMed:25612671).

    Alternative splice isoforms for RTN2 Gene


neXtProt entry for RTN2 Gene

Post-translational modifications for RTN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTN2 Gene

Antibody Products

No data available for DME Specific Peptides for RTN2 Gene

Domains & Families for RTN2 Gene

Protein Domains for RTN2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 reticulon domain.
  • Contains 1 reticulon domain.
genes like me logo Genes that share domains with RTN2: view

No data available for Gene Families for RTN2 Gene

Function for RTN2 Gene

Molecular function for RTN2 Gene

GENATLAS Biochemistry:
reticulon 2 neuroendocrine specific protein-like sequence 1,with two alternative spliced forms RTN2A,RTN2B and a truncated RTN2C form,highly expressed in skeletal muscle

Gene Ontology (GO) - Molecular Function for RTN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22232211
genes like me logo Genes that share ontologies with RTN2: view
genes like me logo Genes that share phenotypes with RTN2: view

Human Phenotype Ontology for RTN2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for RTN2 Gene

MGI Knock Outs for RTN2:

Animal Model Products

  • Taconic Biosciences Mouse Models for RTN2

miRNA for RTN2 Gene

miRTarBase miRNAs that target RTN2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for RTN2 Gene

Localization for RTN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTN2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTN2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
nucleus 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for RTN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 22232211
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0014802 terminal cisterna IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RTN2: view

Pathways & Interactions for RTN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RTN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046324 regulation of glucose import IEA --
GO:0065002 intracellular protein transmembrane transport IEA --
genes like me logo Genes that share ontologies with RTN2: view

No data available for Pathways by source and SIGNOR curated interactions for RTN2 Gene

Transcripts for RTN2 Gene

Unigene Clusters for RTN2 Gene

Reticulon 2:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - -
SP8: -
SP9: -

Relevant External Links for RTN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RTN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RTN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RTN2 Gene

This gene is overexpressed in Muscle - Skeletal (x10.3).

Protein differential expression in normal tissues from HIPED for RTN2 Gene

This gene is overexpressed in Tonsil (27.7) and Platelet (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RTN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RTN2 Gene:


SOURCE GeneReport for Unigene cluster for RTN2 Gene:


mRNA Expression by UniProt/SwissProt for RTN2 Gene:

Tissue specificity: Isoform RTN2-C is highly expressed in skeletal muscle.
genes like me logo Genes that share expression patterns with RTN2: view

No data available for Protein tissue co-expression partners for RTN2 Gene

Orthologs for RTN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RTN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia RTN2 34 35
  • 87.49 (n)
(Mus musculus)
Mammalia Rtn2 34 16 35
  • 82.58 (n)
(Bos Taurus)
Mammalia RTN2 34 35
  • 82.37 (n)
(Rattus norvegicus)
Mammalia Rtn2 34
  • 81.82 (n)
(Monodelphis domestica)
Mammalia RTN2 35
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 21 (a)
(Anolis carolinensis)
Reptilia RTN2 35
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rtn2 34
  • 53.16 (n)
Str.13645 34
(Danio rerio)
Actinopterygii rtn2a 35
  • 42 (a)
rtn2b 35
  • 35 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rtnl2 35
  • 21 (a)
CG42853 35
  • 20 (a)
Rtnl1 35
  • 20 (a)
(Caenorhabditis elegans)
Secernentea ret-1 35
  • 3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10170 35
  • 23 (a)
Species where no ortholog for RTN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RTN2 Gene

Gene Tree for RTN2 (if available)
Gene Tree for RTN2 (if available)

Paralogs for RTN2 Gene

Paralogs for RTN2 Gene

(3) SIMAP similar genes for RTN2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RTN2: view

Variants for RTN2 Gene

Sequence variations from dbSNP and Humsavar for RTN2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs140494585 Spastic paraplegia 12, autosomal dominant (SPG12) [MIM:604805], Pathogenic 45,489,487(+) GGAGG(A/G)AGACC reference, missense
rs10401270 Likely benign 45,494,989(+) AAATC(A/G)GAGTC upstream-variant-2KB, reference, synonymous-codon
rs765432276 Likely benign 45,489,447(+) TGCGC(A/G)GCCAC reference, synonymous-codon
rs876657982 Uncertain significance 45,494,421(-) TATCA(G/T)AACTG upstream-variant-2KB, splice-acceptor-variant
rs139232850 Benign 45,494,641(+) ACCCA(C/G)CCCAG upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RTN2 Gene

Variant ID Type Subtype PubMed ID
nsv833848 CNV loss 17160897

Variation tolerance for RTN2 Gene

Residual Variation Intolerance Score: 31.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RTN2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTN2 Gene

Disorders for RTN2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RTN2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spastic paraplegia 12, autosomal dominant
  • spg12
spastic paraplegia 12
  • spastic paraplegia 12, autosomal dominant
  • paraplegia, lower
- elite association - COSMIC cancer census association via MalaCards
Search RTN2 in MalaCards View complete list of genes associated with diseases


  • Spastic paraplegia 12, autosomal dominant (SPG12) [MIM:604805]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. {ECO:0000269 PubMed:22232211}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RTN2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RTN2: view

No data available for Genatlas for RTN2 Gene

Publications for RTN2 Gene

  1. Molecular cloning of a novel mouse gene with predominant muscle and neural expression. (PMID: 9530622) Geisler J.G. … Mucenski M.L. (Mamm. Genome 1998) 2 3 4 22 64
  2. Mutations in the ER-shaping protein reticulon 2 cause the axon- degenerative disorder hereditary spastic paraplegia type 12. (PMID: 22232211) Montenegro G. … Zuchner S. (J. Clin. Invest. 2012) 2 3 4 64
  3. cDNA cloning, genomic organization, and expression of the human RTN2 gene, a member of a gene family encoding reticulons. (PMID: 9693037) Roebroek A.J.M. … Van de Ven W.J.M. (Genomics 1998) 3 4 22 64
  4. Identification and characterization of TMEM33 as a reticulon-binding protein. (PMID: 25612671) Urade T. … Sakisaka T. (Kobe J Med Sci 2014) 3 4 64
  5. A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family. (PMID: 12832288) Oertle T. … Schwab M.E. (FASEB J. 2003) 3 4 64

Products for RTN2 Gene

Sources for RTN2 Gene

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