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Aliases for RTN1 Gene

Aliases for RTN1 Gene

  • Reticulon 1 2 3 5
  • Neuroendocrine-Specific Protein 2 3 4
  • NSP 3 4
  • Reticulon-1 3

External Ids for RTN1 Gene

Previous HGNC Symbols for RTN1 Gene

  • NSP

Previous GeneCards Identifiers for RTN1 Gene

  • GC14M057386
  • GC14M053855
  • GC14M058052
  • GC14M059132
  • GC14M060062
  • GC14M040226

Summaries for RTN1 Gene

Entrez Gene Summary for RTN1 Gene

  • This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]

GeneCards Summary for RTN1 Gene

RTN1 (Reticulon 1) is a Protein Coding gene. An important paralog of this gene is RTN4.

UniProtKB/Swiss-Prot for RTN1 Gene

  • May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.

Gene Wiki entry for RTN1 Gene

Additional gene information for RTN1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTN1 Gene

Genomics for RTN1 Gene

Regulatory Elements for RTN1 Gene

Enhancers for RTN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H060183 1.3 Ensembl ENCODE dbSUPER 13.5 -313.2 -313211 1.8 TBP CTCF PKNOX1 RB1 RAD21 RFX5 SMC3 ZNF143 ATF7 PRDM10 RTN1 PPM1A LOC101927702 C14orf39 GC14P060180 RPL17P2
GH14H060178 1.1 Ensembl ENCODE dbSUPER 12.7 -308.8 -308786 1.6 PKNOX1 JUNB BATF ZNF316 NFE2 RUNX3 MAFK PRDM1 NFE2L2 PPM1A RTN1 LOC101927702 PCNX4 C14orf39 GC14P060180 RPL17P2
GH14H059405 1.3 FANTOM5 Ensembl ENCODE 10.6 +463.8 463780 2.6 ELF3 SOX13 TFAP4 JUN RAD21 TCF12 NCOR1 HNF4G FOS MAFK L3HYPDH JKAMP RTN1 DAAM1 RBM8B GC14P059386 PIR32681
GH14H060150 1.6 FANTOM5 Ensembl ENCODE dbSUPER 7.2 -281.0 -281037 2.4 PKNOX1 ZNF146 JUN MAX SIN3A CTBP1 GATA3 ELK1 POLR2A FOS DHRS7 PCNX4 RTN1 PPM1A GC14P060159 SCOCP1 GC14P060140
GH14H059918 1 ENCODE 11.2 -48.8 -48841 1.9 FOXA2 ETS1 GLIS2 ZNF143 SP3 SP5 NFYC REST SREBF1 MIER3 RTN1 CCDC175 ENSG00000261120 LRRC9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RTN1 on UCSC Golden Path with GeneCards custom track

Promoters for RTN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000069205 466 1001 CTCF MXI1 BMI1 ZIC2 CTBP1 POLR2A ZBTB48 ZNF600 PRDM10 ZBTB20

Genomic Locations for RTN1 Gene

Genomic Locations for RTN1 Gene
274,991 bases
Minus strand

Genomic View for RTN1 Gene

Genes around RTN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTN1 Gene

Proteins for RTN1 Gene

  • Protein details for RTN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q16800
    • Q16801
    • Q5BKZ4
    • Q9BQ59

    Protein attributes for RTN1 Gene

    776 amino acids
    Molecular mass:
    83618 Da
    Quaternary structure:
    • Interacts with NDRG1 (PubMed:15922294). Isoform RTN1-A interacts with TMEM33 (PubMed:25612671).

    Alternative splice isoforms for RTN1 Gene


neXtProt entry for RTN1 Gene

Post-translational modifications for RTN1 Gene

Other Protein References for RTN1 Gene

No data available for DME Specific Peptides for RTN1 Gene

Domains & Families for RTN1 Gene

Gene Families for RTN1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for RTN1 Gene


Suggested Antigen Peptide Sequences for RTN1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RTN1: view

No data available for UniProtKB/Swiss-Prot for RTN1 Gene

Function for RTN1 Gene

Molecular function for RTN1 Gene

GENATLAS Biochemistry:
reticulon 1,neuroendocrine specific protein,associated with the endoplasmic reticulum (reticulor),expressed in neural and endocrine tissues
UniProtKB/Swiss-Prot Function:
May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.

Phenotypes From GWAS Catalog for RTN1 Gene

Gene Ontology (GO) - Molecular Function for RTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17684057
genes like me logo Genes that share ontologies with RTN1: view

Phenotypes for RTN1 Gene

genes like me logo Genes that share phenotypes with RTN1: view

Animal Model Products

miRNA for RTN1 Gene

miRTarBase miRNAs that target RTN1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RTN1 Gene

Localization for RTN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTN1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTN1 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA,IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030176 integral component of endoplasmic reticulum membrane TAS 8833145
genes like me logo Genes that share ontologies with RTN1: view

Pathways & Interactions for RTN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RTN1 Gene


No data available for Pathways by source and SIGNOR curated interactions for RTN1 Gene

Drugs & Compounds for RTN1 Gene

No Compound Related Data Available

Transcripts for RTN1 Gene

Unigene Clusters for RTN1 Gene

Reticulon 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTN1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d
SP1: - - -
SP2: - -
SP3: -

Relevant External Links for RTN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RTN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RTN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RTN1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.2), Brain - Anterior cingulate cortex (BA24) (x6.4), Brain - Cortex (x5.9), Brain - Cerebellar Hemisphere (x5.0), and Brain - Cerebellum (x4.0).

Protein differential expression in normal tissues from HIPED for RTN1 Gene

This gene is overexpressed in Fetal Brain (16.4), Brain (14.7), and Frontal cortex (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RTN1 Gene

Protein tissue co-expression partners for RTN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RTN1 Gene:


SOURCE GeneReport for Unigene cluster for RTN1 Gene:


mRNA Expression by UniProt/SwissProt for RTN1 Gene:

Tissue specificity: Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation.

Evidence on tissue expression from TISSUES for RTN1 Gene

  • Nervous system(5)
  • Lung(4.4)
  • Blood(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with RTN1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RTN1 Gene

Orthologs for RTN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RTN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RTN1 33 34
  • 98.97 (n)
(Bos Taurus)
Mammalia RTN1 33 34
  • 87.54 (n)
(Canis familiaris)
Mammalia RTN1 33 34
  • 87.37 (n)
(Mus musculus)
Mammalia Rtn1 33 16 34
  • 83.42 (n)
(Rattus norvegicus)
Mammalia Rtn1 33
  • 83.29 (n)
(Monodelphis domestica)
Mammalia RTN1 34
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia RTN1 34
  • 63 (a)
(Gallus gallus)
Aves RTN1 33 34
  • 67.8 (n)
(Anolis carolinensis)
Reptilia RTN1 34
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rtn1 33
  • 62.94 (n)
(Danio rerio)
Actinopterygii rtn1a 33 34
  • 54.32 (n)
rtn1b 34
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rtnl1 34
  • 25 (a)
Rtnl2 34
  • 23 (a)
CG42853 34
  • 16 (a)
(Caenorhabditis elegans)
Secernentea ret-1 34
  • 5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10170 34
  • 31 (a)
Species where no ortholog for RTN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RTN1 Gene

Gene Tree for RTN1 (if available)
Gene Tree for RTN1 (if available)

Paralogs for RTN1 Gene

Paralogs for RTN1 Gene

(5) SIMAP similar genes for RTN1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RTN1: view

Variants for RTN1 Gene

Sequence variations from dbSNP and Humsavar for RTN1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000006785 -- 59,756,691(+) CAGAT(C/T)CCCTC intron-variant
rs1000015672 -- 59,805,182(+) TTAAT(C/T)ACTCC intron-variant
rs1000020589 -- 59,814,986(+) TTATA(C/T)ATTGT intron-variant
rs1000020971 -- 59,606,630(+) GTCTA(C/T)GGTAT intron-variant
rs1000027637 -- 59,833,759(+) ATGCA(G/T)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RTN1 Gene

Variant ID Type Subtype PubMed ID
nsv958765 CNV deletion 24416366
nsv832811 CNV loss 17160897
nsv1292 CNV insertion 18451855
nsv1140129 CNV insertion 24896259
nsv1134380 CNV deletion 24896259
nsv1131142 CNV deletion 24896259
nsv1120297 CNV tandem duplication 24896259
nsv1070639 CNV deletion 25765185
esv3634656 CNV loss 21293372
esv3634655 CNV loss 21293372
esv3634654 CNV loss 21293372
esv3634653 CNV loss 21293372
esv3451830 CNV insertion 20981092
esv3401189 CNV insertion 20981092
esv3363514 CNV duplication 20981092
esv3306309 CNV mobile element insertion 20981092
esv2748748 CNV deletion 23290073
esv2673231 CNV deletion 23128226
esv2672267 CNV deletion 23128226
esv2656864 CNV deletion 23128226
esv1643485 CNV deletion 17803354
esv1373092 CNV insertion 17803354

Variation tolerance for RTN1 Gene

Residual Variation Intolerance Score: 75.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.85; 67.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RTN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTN1 Gene

Disorders for RTN1 Gene

Relevant External Links for RTN1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RTN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RTN1 Gene

Publications for RTN1 Gene

  1. Neuronal differentiation is accompanied by NSP-C expression. (PMID: 9560466) Hens J … Broers JL (Cell and tissue research 1998) 3 4 22 60
  2. Identification and characterization of TMEM33 as a reticulon-binding protein. (PMID: 25612671) Urade T … Sakisaka T (The Kobe journal of medical sciences 2014) 3 4 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Reticulon proteins: emerging players in neurodegenerative diseases. (PMID: 16505974) Yan R … Zhou X (Cellular and molecular life sciences : CMLS 2006) 3 22 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for RTN1 Gene

Sources for RTN1 Gene

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