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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RTN1 Gene

protein-coding   GIFtS: 57
GCID: GC14M060062

reticulon 1

(Previous name: neuroendocrine-specific protein )
(Previous symbol: NSP)
 Explore 12 diseases affiliated with
RTN1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RTN1    

Aliases
for RTN1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Reticulon 11 2
NSP1 2 3 5
Neuroendocrine-Specific Protein1 2 3
Reticulon-11

External Ids:    HGNC: 104671   Entrez Gene: 62522   Ensembl: ENSG000001399707   OMIM: 6008655   UniProtKB: Q167993   

Export aliases for RTN1 gene to outside databases

Previous GC identifers: GC14M057386 GC14M053855 GC14M058052 GC14M059132 GC14M040226


Summaries
for RTN1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RTN1:
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum,
and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is
considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for
therapy. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jul 2011)

UniProtKB/Swiss-Prot: RTN1_HUMAN, Q16799
Function: May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells

Gene Wiki entry for RTN1


Genomic Views
for RTN1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RTN1 gene promoter:
         NF-1   AML1a   Sp1   Tal-1   CUTL1   E47   FOXL1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RTN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RTN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RTN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.1   Ensembl cytogenetic band:  14q23.1   HGNC cytogenetic band: 14q21-q22

RTN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTN1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M060062:  view genomic region     (about GC identifiers)

Start:
 60,062,694 bp from pter      End:
 60,337,684 bp from pter
Size:
 274,991 bases      Orientation:
 minus strand

Proteins
for RTN1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RTN1_HUMAN, Q16799 (See protein sequence)
Recommended Name: Reticulon-1  
Size: 776 amino acids; 83618 Da
Subunit: Interacts with NDRG1
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: Q16800 Q16801 Q5BKZ4 Q9BQ59
Alternative splicing: 3 isoforms:  Q16799-1   Q16799-2   Q16799-3   

Explore the universe of human proteins at neXtProt for RTN1: NX_Q16799

Post-translational modifications:

  • Isoforms RTN1-A and RTN1-B are phosphorylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16799

    • RTN1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_066959.1  NP_996734.1  

    ENSEMBL proteins: 
     ENSP00000378525   ENSP00000340716   ENSP00000267484  

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    Novus Biologicals RTN1 Protein
    Novus Biologicals RTN1 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RTN1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ----
    GO:0030176integral to endoplasmic reticulum membrane TAS8833145


    RTN1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RTN1

    Protein Domains /
    Families
    for RTN1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RTN1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR003388 Reticulon

    Graphical View of Domain Structure for InterPro Entry Q16799

    ProtoNet protein and cluster: Q16799

    1 Blocks protein family: IPB003388 Reticulon

    UniProtKB/Swiss-Prot: RTN1_HUMAN, Q16799
    Similarity: Contains 1 reticulon domain


    Function
    for RTN1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RTN1_HUMAN, Q16799
    Function: May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells

         Genatlas biochemistry entry for RTN1:
    reticulon 1,neuroendocrine specific protein,associated with the endoplasmic reticulum (reticulor),expressed in neural
    and endocrine tissues

    miRNA
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    hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-301a hsa-miR-519a hsa-miR-374c hsa-miR-372 hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmid: RTN1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RTN1 (see all 7)
    OriGene shRNA RFP: RTN1
    OriGene siRNA: RTN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RTN1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RTN1

    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for RTN1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity NAS--
    GO:0005515protein binding IPI17786215


    RTN1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for RTN1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RTN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/21 Interacting proteins for RTN1 (Q167992, 3 ENSP000002674844) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLEKHF2Q9H8W42, 3, ENSP000003223734MINT-67163 I2D: score=5 STRING: ENSP00000322373
    FAM160A2Q8N6122, 3, ENSP000002659784MINT-66243 I2D: score=5 STRING: ENSP00000265978
    UGCGQ167393, ENSP000003633974I2D: score=2 STRING: ENSP00000363397
    HDAC8Q9BY413, ENSP000003626744I2D: score=1 STRING: ENSP00000362674
    SPASTQ9UBP03, ENSP000003208854I2D: score=1 STRING: ENSP00000320885
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction NAS--
    GO:0030182neuron differentiation IEP9560466


    RTN1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RTN1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RTN1
    Search CenterWatch for drugs/clinical trials and news about RTN1 

    Transcripts
    for RTN1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RTN1 gene (4 alternative transcripts): 
    NM_021136.2  NM_206852.2  NM_001243115.1  NM_206857.1  

    Unigene Cluster for RTN1:

    Reticulon 1
    Hs.368626  [show with all ESTs]
    Unigene Representative Sequence: NM_021136
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481205 ENST00000395090 ENST00000342503(uc001xek.2 uc010apl.2)
    ENST00000267484(uc001xen.1) ENST00000432103(uc001xem.1) ENST00000474911
    ENST00000557422 ENST00000490111

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RTN1
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate RTN1 (see all 49):
    hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-301a hsa-miR-519a hsa-miR-374c hsa-miR-372 hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmid: RTN1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RTN1 (see all 7)
    OriGene shRNA RFP: RTN1
    OriGene siRNA: RTN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RTN1
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): RTN1 (NM_021136)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTN1

    Additional cDNA sequence: 

    AK290534.1 AK297492.1 BC000314.2 BC003003.1 BC068510.1 BC090862.1 BC111694.1 CR457030.1 
    DQ355431.1 L10333.1 L10334.1 L10335.1 

    24/29 DOTS entries (see all 29):

    DT.100887858  DT.97844639  DT.95371410  DT.100887849  DT.100798895  DT.100887869  DT.100887852  DT.91760833 
    DT.100887851  DT.100887866  DT.100887841  DT.100887853  DT.91760857  DT.95371413  DT.100647968  DT.100762434 
    DT.100887839  DT.100887845  DT.100887847  DT.100887862  DT.100025173  DT.100801569  DT.100832517  DT.100887843 

    24/485 AceView cDNA sequences (see all 485):

    BU733835 F10687 BX422879 CR612754 BX442187 BX423055 BX410816 AI929583 
    R19734 AW163489 CR616369 BX445074 CR602429 AW161929 AI436022 CR622144 
    F02112 CR611210 AI878860 BX462047 CR591277 CR603795 BX460584 CR609190 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RTN1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d
    SP1:              -           -           -                                                   
    SP2:                          -           -                                                   
    SP3:                                      -                                                   
    SP4:                                                                                          


    ECgene alternative splicing isoforms for RTN1

    Expression
    for RTN1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RTN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTAACTTTAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RTN1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeRetinaEye
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Ventral/hypothalamic-like neurons (Generation of midbra...)

    See RTN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RTN1

    SOURCE GeneReport for Unigene cluster: Hs.368626

    UniProtKB/Swiss-Prot: RTN1_HUMAN, Q16799
    Tissue specificity: Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of
    isoform RTN1-C is strongly correlated with neuronal differentiation

        SABiosciences Expression via Pathway-Focused PCR Array including RTN1: 
              Parkinson's Disease in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for RTN1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RTN1 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RTN11 reticulon 1 67.38(n)
    63.94(a)    		   378791  NM_001001466.1  NP_001001466.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RTN16
    		 --
    		 63(a)
    		 1 ↔ 1
    		 GL343261.1(1434544-1517478)
    African clawed frog
    (Xenopus laevis)    		 Amphibia CD360654.12   -- 78.34(n)    CD360654.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC052753.12   -- 76.19(n)    BC052753.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Rtnl26
    Rtnl16
    (see all 3)    		 Rtnl1
    (see all 3)    		 22(a)
    21(a)
    (see all 3)    		 possible ortholog
    1 ↔ many
    (see all 3)    		 3R(3354586-3355963)
    2L(4992808-5009720)


    ENSEMBL Gene Tree for RTN1 (if available)
    TreeFam Gene Tree for RTN1 (if available) 

    Paralogs
    for RTN1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RTN1 gene
    RTN32  RTN42  RTN22  
    5 SIMAP similar genes for RTN1 using alignment to 5 protein entries:     RTN1_HUMAN (see all proteins):
    Nbla00271    NOGOC    RTN3    RTN4    RTN2

    RTN1 for paralogs           About GeneDecksing



    Genomic Variants
    for RTN1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4243 NCBI SNPs in RTN1 are shown (see all 4243)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs774951911,2
    		F,--40226002(+) TGAAAC/TAAAAT 2 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1116733841,2
    		C,--40226356(+) GCCAGG/CTTGCA 2 -- ds50012Minor allele frequency- C:0.07NA 122
    rs750321611,2
    		F,--40226450(+) TCGAGC/GTTTTG 2 -- ds50012Minor allele frequency- G:0.05WA NA 238
    rs349669771,2
    		C,--40226689(+) CTGCA-/TGTTTG 2 -- ut310--------
    rs138041,2
    		C,--40227001(-) CATGAT/CGGTGA 2 -- ut313Minor allele frequency- C:0.04MN CSA WA 304
    rs454818981,2
    		C,--40227171(+) GGGGGG/AAAGAC 2 -- ut311Minor allele frequency- A:0.50NA 2
    rs1117036481,2
    		C,--40227171(+) GGGGG-/AAAGAC 2 -- ut311Minor allele frequency- A:0.50CSA 2
    rs1134435921,2
    		C,--40228224(+) GTGAGG/AGGCAC 2 -- int13Minor allele frequency- A:0.04NA EA 242
    rs727161141,2
    		C,--40228574(+) AGAAGA/TTCATG 2 -- int13Minor allele frequency- T:0.05CSA WA NA 240
    rs772893341,2
    		C,--40228588(+) GTGGCT/CGTGTA 2 -- int12Minor allele frequency- C:0.07NA 122

    HapMap Linkage Disequilibrium report for RTN1 (60062694 - 60312694 bp, first 250kb of RTN1)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RTN1
         1 Indel: 25417

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RTN1
    DNA2.0 Custom Variant and Variant Library Synthesis for RTN1

    Disorders / Diseases
    for RTN1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RTN1 for disorders           About GeneDecksing

    OMIM gene information: 600865    OMIM disorders: --

    12 diseases for RTN1:    About MalaCards
    spastic paraplegia    hereditary spastic paraplegia    neurologic diseases    paraplegia
    spasticity    neuroepithelioma    neuroectodermal tumors    neurodegenerative disease
    parkinson's disease    lung cancer    neuroblastoma    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: RTN1 (2 documents)

    Export disorders for RTN1 gene to outside databases

    Publications
    for RTN1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RTN1 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with RTN1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Neuronal differentiation is accompanied by NSP-C expression. (PubMed id 9560466)1, 2, 9 Hens J.... Broers J.L. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Genomic organization of the human NSP gene, prototype of a novel gene family encoding reticulons. (PubMed id 8833145)1, 2 Roebroek A.J.M.... Van de Ven W.J.M. (1996)
    4. Regional mapping of the human NSP gene to chromosome region 14q21-->q22 by fluorescence in situ hybridization analysis. (PubMed id 8275708)1, 3 Kools P.F....Van de Ven W.J. (1994)
    5. Cloning and expression of alternative transcripts of a novel neuroendocrine-specific gene and identification of its 135-kDa translational product. (PubMed id 7685762)1, 2 Roebroek A.J.M.... Van de Ven W.J.M. (1993)
    6. Cluster-10 lung-cancer antibodies recognize NSPs, novel neuro-endocrine proteins associated with membranes of the endoplasmic reticulum. (PubMed id 7515034)1, 9 Senden N.H....Ramaekers F.C. (1994)
    7. NSP-encoded reticulons are neuroendocrine markers of a novel category in human lung cancer diagnosis. (PubMed id 8062278)1, 9 van de Velde H.J....Van de Ven W.J. (1994)
    8. Reticulon proteins: emerging players in neurodegenerative diseases. (PubMed id 16505974)1, 9 Yan R....Zhou X. (2006)
    9. Human reticulon 1-A and 1-B interact with a medium chain of the AP-2 adaptor complex. (PubMed id 14995077)1, 9 Iwahashi J. and Hamada N. (2003)
    10. NSP-encoded reticulons, neuroendocrine proteins of a novel gene family associated with membranes of the endoplasmic reticulum. (PubMed id 7844160)1, 9 van de Velde H.J....Van de Ven W.J. (1994)

    External Searches for RTN1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing RTN1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6252 HGNC: 10467 AceView: RTN1 Ensembl:ENSG00000139970 euGenes: HUgn6252
    ECgene: RTN1 H-InvDB: RTN1

    Other Databases showing RTN1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RTN1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RTN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RTN1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RTN1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RTN1 gene:
    Search GeneIP for patents involving RTN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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