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Aliases for RTN1 Gene

Aliases for RTN1 Gene

  • Reticulon 1 2 3
  • Neuroendocrine-Specific Protein 2 3 4
  • NSP 3 4 6
  • Reticulon-1 3

External Ids for RTN1 Gene

Previous Symbols for RTN1 Gene

  • NSP

Summaries for RTN1 Gene

Entrez Gene Summary for RTN1 Gene

  • This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]

GeneCards Summary for RTN1 Gene

RTN1 (Reticulon 1) is a Protein Coding gene. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is RTN3.

UniProtKB/Swiss-Prot for RTN1 Gene

  • May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells

Gene Wiki entry for RTN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTN1 Gene

Genomics for RTN1 Gene

Genomic Location for RTN1 Gene

59,595,976 bp from pter
59,870,966 bp from pter
274,991 bases
Minus strand

Genomic View for RTN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RTN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTN1 Gene

Regulatory Elements for RTN1 Gene

Proteins for RTN1 Gene

  • Protein details for RTN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q16800
    • Q16801
    • Q5BKZ4
    • Q9BQ59

    Protein attributes for RTN1 Gene

    776 amino acids
    Molecular mass:
    83618 Da
    Quaternary structure:
    • Interacts with NDRG1.

    Alternative splice isoforms for RTN1 Gene


neXtProt entry for RTN1 Gene

Proteomics data for RTN1 Gene at MOPED

Post-translational modifications for RTN1 Gene

Other Protein References for RTN1 Gene

No data available for DME Specific Peptides for RTN1 Gene

Domains for RTN1 Gene

Protein Domains for RTN1 Gene



  • Contains 1 reticulon domain.:
    • Q16799
genes like me logo Genes that share domains with RTN1: view

No data available for Gene Families for RTN1 Gene

Function for RTN1 Gene

Molecular function for RTN1 Gene

GENATLAS Biochemistry: reticulon 1,neuroendocrine specific protein,associated with the endoplasmic reticulum (reticulor),expressed in neural and endocrine tissues
UniProtKB/Swiss-Prot Function: May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells

Gene Ontology (GO) - Molecular Function for RTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17684057
genes like me logo Genes that share ontologies with RTN1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RTN1 Gene

Localization for RTN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTN1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for RTN1 Gene COMPARTMENTS Subcellular localization image for RTN1 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 2
cytoskeleton 1
cytosol 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IDA 17684057
GO:0016021 integral component of membrane --
GO:0030176 integral component of endoplasmic reticulum membrane TAS 8833145
genes like me logo Genes that share ontologies with RTN1: view

Pathways for RTN1 Gene

SuperPathways for RTN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030182 neuron differentiation IEP 9560466
genes like me logo Genes that share ontologies with RTN1: view

No data available for Pathways by source for RTN1 Gene

Transcripts for RTN1 Gene

Unigene Clusters for RTN1 Gene

Reticulon 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RTN1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d
SP1: - - -
SP2: - -
SP3: -

Relevant External Links for RTN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RTN1 Gene

mRNA expression in normal human tissues for RTN1 Gene

mRNA differential expression in normal tissues according to GTEx for RTN1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (7.2), Brain - Anterior cingulate cortex (BA24) (6.4), Brain - Cortex (5.9), Brain - Cerebellar Hemisphere (5.0), and Brain - Cerebellum (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RTN1 Gene

SOURCE GeneReport for Unigene cluster for RTN1 Gene Hs.368626

mRNA Expression by UniProt/SwissProt for RTN1 Gene

Tissue specificity: Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation.
genes like me logo Genes that share expressions with RTN1: view

Orthologs for RTN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RTN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RTN1 36
  • 98.97 (n)
  • 98.45 (a)
RTN1 37
  • 98 (a)
(Bos Taurus)
Mammalia RTN1 36
  • 87.54 (n)
  • 86.08 (a)
RTN1 37
  • 87 (a)
(Canis familiaris)
Mammalia RTN1 36
  • 87.37 (n)
  • 85.33 (a)
RTN1 37
  • 83 (a)
(Mus musculus)
Mammalia Rtn1 36
  • 83.42 (n)
  • 82.22 (a)
Rtn1 16
Rtn1 37
  • 82 (a)
(Monodelphis domestica)
Mammalia RTN1 37
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia RTN1 37
  • 63 (a)
(Rattus norvegicus)
Mammalia Rtn1 36
  • 83.29 (n)
  • 82.04 (a)
(Gallus gallus)
Aves RTN1 36
  • 67.8 (n)
  • 65.03 (a)
RTN1 37
  • 62 (a)
(Anolis carolinensis)
Reptilia RTN1 37
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rtn1 36
  • 62.94 (n)
  • 63.09 (a)
(Danio rerio)
Actinopterygii rtn1a 36
  • 54.32 (n)
  • 48.45 (a)
rtn1a 37
  • 34 (a)
rtn1b 37
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42853 37
  • 16 (a)
Rtnl1 37
  • 25 (a)
Rtnl2 37
  • 23 (a)
(Caenorhabditis elegans)
Secernentea ret-1 37
  • 5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10170 37
  • 31 (a)
Species with no ortholog for RTN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RTN1 Gene

Gene Tree for RTN1 (if available)
Gene Tree for RTN1 (if available)

Paralogs for RTN1 Gene

Paralogs for RTN1 Gene

Selected SIMAP similar genes for RTN1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RTN1: view

Variants for RTN1 Gene

Sequence variations from dbSNP and Humsavar for RTN1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs13804 -- 59,596,484(-) CATGA(C/T)GGTGA utr-variant-3-prime
rs723384 -- 59,601,262(-) AAAGA(C/T)GTTGC intron-variant
rs723385 -- 59,601,423(-) ATATA(A/G)TAAGT intron-variant
rs726041 -- 59,606,764(-) TTATA(C/G)TGGGG intron-variant
rs726462 -- 59,608,600(-) CTGAT(A/T)TACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RTN1 Gene

Variant ID Type Subtype PubMed ID
nsv901990 CNV Loss 21882294
nsv832811 CNV Loss 17160897
esv2672267 CNV Deletion 23128226
esv2748748 CNV Deletion 23290073
esv2656864 CNV Deletion 23128226
esv1643485 CNV Deletion 17803354
esv1373092 CNV Insertion 17803354
nsv1292 CNV Insertion 18451855
esv2673231 CNV Deletion 23128226
esv270586 CNV Insertion 20981092

Relevant External Links for RTN1 Gene

HapMap Linkage Disequilibrium report

Disorders for RTN1 Gene

Relevant External Links for RTN1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RTN1: view

No data available for UniProtKB/Swiss-Prot for RTN1 Gene

Publications for RTN1 Gene

  1. Neuronal differentiation is accompanied by NSP-C expression. (PMID: 9560466) Hens J. … Broers J.L. (Cell Tissue Res. 1998) 3 4 23
  2. Cluster-10 lung-cancer antibodies recognize NSPs, novel neuro-endocrine proteins associated with membranes of the endoplasmic reticulum. (PMID: 7515034) Senden N.H. … Ramaekers F.C. (Int. J. Cancer Suppl. 1994) 3 23
  3. NSP-encoded reticulons, neuroendocrine proteins of a novel gene family associated with membranes of the endoplasmic reticulum. (PMID: 7844160) van de Velde H.J. … Van de Ven W.J. (J. Cell. Sci. 1994) 3 23
  4. NSP-encoded reticulons are neuroendocrine markers of a novel category in human lung cancer diagnosis. (PMID: 8062278) van de Velde H.J. … Van de Ven W.J. (Cancer Res. 1994) 3 23
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for RTN1 Gene

Sources for RTN1 Gene

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