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RTN1 Gene

protein-coding   GIFtS: 58
GCID: GC14M060062

Reticulon 1

(Previous name: neuroendocrine-specific protein)
(Previous symbol: NSP)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Reticulon 11 2
NSP1 2 3 5
Neuroendocrine-Specific Protein1 2 3
reticulon-12

External Ids:    HGNC: 104671   Entrez Gene: 62522   Ensembl: ENSG000001399707   OMIM: 6008655   UniProtKB: Q167993   

Export aliases for RTN1 gene to outside databases

Previous GC identifers: GC14M057386 GC14M053855 GC14M058052 GC14M059132 GC14M040226


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RTN1 Gene:
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic
reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This
gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular
target for therapy. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jul 2011)

GeneCards Summary for RTN1 Gene:
RTN1 (reticulon 1) is a protein-coding gene. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is RTN3.

UniProtKB/Swiss-Prot: RTN1_HUMAN, Q16799
Function: May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells

Gene Wiki entry for RTN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the RTN1 gene promoter:
         NF-1   AML1a   Sp1   Tal-1   CUTL1   E47   FOXL1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RTN1 promoter sequence
   Search Chromatin IP Primers for RTN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RTN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.1   Ensembl cytogenetic band:  14q23.1   HGNC cytogenetic band: 14q21-q22

RTN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTN1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M060062:  view genomic region     (about GC identifiers)

Start:
60,062,694 bp from pter      End:
60,337,684 bp from pter
Size:
274,991 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RTN1_HUMAN, Q16799 (See protein sequence)
Recommended Name: Reticulon-1  
Size: 776 amino acids; 83618 Da
Subunit: Interacts with NDRG1
Secondary accessions: Q16800 Q16801 Q5BKZ4 Q9BQ59
Alternative splicing: 3 isoforms:  Q16799-1   Q16799-2   Q16799-3   

Explore the universe of human proteins at neXtProt for RTN1: NX_Q16799

Explore proteomics data for RTN1 at MOPED

Post-translational modifications: 

  • Isoforms RTN1-A and RTN1-B are phosphorylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RTN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_066959.1  NP_996734.1  

    ENSEMBL proteins: 
     ENSP00000378525   ENSP00000340716   ENSP00000267484  

    RTN1 Human Recombinant Protein Products:

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    Novus Biologicals RTN1 Protein
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    Cloud-Clone Corp. Proteins for RTN1

     
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    antibodies-online proteins for RTN1 (2 products) 

     
    antibodies-online peptides for RTN1

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    antibodies-online antibodies for RTN1 (56 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003388 Reticulon

    Graphical View of Domain Structure for InterPro Entry Q16799

    ProtoNet protein and cluster: Q16799

    1 Blocks protein domain: IPB003388 Reticulon

    UniProtKB/Swiss-Prot: RTN1_HUMAN, Q16799
    Similarity: Contains 1 reticulon domain


    Find genes that share domains with RTN1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RTN1_HUMAN, Q16799
    Function: May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells

         Genatlas biochemistry entry for RTN1:
    reticulon 1,neuroendocrine specific protein,associated with the endoplasmic reticulum (reticulor),expressed in
    neural and endocrine tissues

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity ----
    GO:0005515protein binding IPI17786215
         
    Find genes that share ontologies with RTN1           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Rtn1 (no phenotypes)

    Find genes that share phenotypes with RTN1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RTN1

    miRNA
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    Block miRNA regulation of human, mouse, rat RTN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RTN1 (see all 49):
    hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-301a hsa-miR-519a hsa-miR-374c hsa-miR-372 hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidRTN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RTN1
    Predesigned siRNA for gene silencing in human, mouse, rat RTN1

    Gene Editing
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    OriGene clones in human, mouse for RTN1 (see all 14)
    OriGene ORF clones in mouse, rat for RTN1
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    GenScript: all cDNA clones in your preferred vector (see all 3): RTN1 (NM_021136)
    Sino Biological Human cDNA Clone for RTN1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RTN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTN1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RTN1_HUMAN, Q16799: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus2
    cytoskeleton1
    cytosol1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ----
    GO:0016021integral component of membrane ----
    GO:0030176integral component of endoplasmic reticulum membrane TAS8833145

    Find genes that share ontologies with RTN1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including RTN1: 
              Parkinson's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RTN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RTN1 (Q167992, 3 ENSP000002674844) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLEKHF2Q9H8W42, 3, ENSP000003223734MINT-67163 I2D: score=5 STRING: ENSP00000322373
    FAM160A2Q8N6122, 3, ENSP000002659784MINT-66243 I2D: score=5 STRING: ENSP00000265978
    UGCGQ167393, ENSP000003633974I2D: score=2 STRING: ENSP00000363397
    HDAC8Q9BY413, ENSP000003626744I2D: score=1 STRING: ENSP00000362674
    SPASTQ9UBP03, ENSP000003208854I2D: score=1 STRING: ENSP00000320885
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0030182neuron differentiation IEP9560466

    Find genes that share ontologies with RTN1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RTN1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RTN1 gene (4 alternative transcripts): 
    NM_021136.2  NM_206852.2  NM_001243115.1  NM_206857.1  

    Unigene Cluster for RTN1:

    Reticulon 1
    Hs.368626  [show with all ESTs]
    Unigene Representative Sequence: NM_021136
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481205 ENST00000395090 ENST00000342503(uc001xek.2 uc010apl.2)
    ENST00000267484(uc001xen.1) ENST00000432103(uc001xem.1) ENST00000474911
    ENST00000557422 ENST00000490111
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RTN1 (see all 49):
    hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-301a hsa-miR-519a hsa-miR-374c hsa-miR-372 hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidRTN1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RTN1
    Predesigned siRNA for gene silencing in human, mouse, rat RTN1
    Clone
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    OriGene clones in human, mouse for RTN1 (see all 14)
    OriGene ORF clones in mouse, rat for RTN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RTN1 (NM_021136)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RTN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTN1
    Primer
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    OriGene qPCR primer pairs and template standards for RTN1
    OriGene qSTAR qPCR primer pairs in human, mouse for RTN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RTN1
      QuantiTect SYBR Green Assays in human, mouse, rat RTN1
      QuantiFast Probe-based Assays in human, mouse, rat RTN1

    Additional mRNA sequence: 

    AK290534.1 AK297492.1 BC000314.2 BC003003.1 BC068510.1 BC090862.1 BC111694.1 CR457030.1 
    DQ355431.1 L10333.1 L10334.1 L10335.1 

    Selected DOTS entries (see all 29):

    DT.100887858  DT.97844639  DT.95371410  DT.100887849  DT.100798895  DT.100887869  DT.100887852  DT.91760833 
    DT.100887851  DT.100887866  DT.100887841  DT.100887853  DT.91760857  DT.95371413  DT.100647968  DT.100762434 
    DT.100887839  DT.100887845  DT.100887847  DT.100887862  DT.100025173  DT.100801569  DT.100832517  DT.100887843 

    Selected AceView cDNA sequences (see all 485):

    BX460584 AI951941 CR618902 CR609190 BM693973 CR602646 AW162308 CR591857 
    CR609607 BX441127 CR602429 AW161929 AI436022 CR622144 CR611210 F02112 
    CR616915 CR604011 AI879085 CR620778 BX418465 AW162817 CR603070 CR612754 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RTN1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d
    SP1:              -           -           -                                                   
    SP2:                          -           -                                                   
    SP3:                                      -                                                   
    SP4:                                                                                          


    ECgene alternative splicing isoforms for RTN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RTN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAACTTTAT
    RTN1 Expression
    About this image


    RTN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Thalamus
             Ventral/hypothalamic-like neurons
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
     
     Oligodendrocytes (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
    RTN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RTN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368626

    UniProtKB/Swiss-Prot: RTN1_HUMAN, Q16799
    Tissue specificity: Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression
    of isoform RTN1-C is strongly correlated with neuronal differentiation

        Pathway & Disease-focused RT2 Profiler PCR Array including RTN1: 
              Parkinson's Disease in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat RTN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RTN1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rtn11 , 5 reticulon 11, 5 83.42(n)1
    82.22(a)1
      12 (30.20 cM)5
    1040011  NM_153457.71  NP_703187.21 
     722117525 
    chicken
    (Gallus gallus)
    Aves RTN11 reticulon 1 67.8(n)
    65.03(a)
      378791  NM_001001466.1  NP_001001466.1 
    lizard
    (Anolis carolinensis)
    Reptilia RTN16
    reticulon 1
    61(a)
    1 ↔ 1
    GL343261.1(1320507-1519332)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD360654.12   -- 78.34(n)    CD360654.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC052753.12   -- 76.19(n)    BC052753.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rtnl16
    Rtnl26
    (see all 3)
    Rtnl2
    (see all 3)
    25(a)
    23(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2L(4992808-5009720)
    3R(3354586-3355963)
    worm
    (Caenorhabditis elegans)
    Secernentea ret-16
    Protein RET-1, isoform c
    5(a)
    1 → many
    V(14829177-14847312) WBGene00004336


    ENSEMBL Gene Tree for RTN1 (if available)
    TreeFam Gene Tree for RTN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RTN1 gene
    RTN32  RTN42  RTN22  
    5 SIMAP similar genes for RTN1 using alignment to 5 protein entries:     RTN1_HUMAN (see all proteins):
    Nbla00271    NOGOC    RTN3    RTN4    RTN2

    Find genes that share paralogs with RTN1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RTN1 (see all 5020)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1417963611,2
    C--40237382(+) AAAGA-/CCCAAA 2 -- int10--------
    rs756068631,2
    C--40294852(-) CTACCT/CCCGCA 1 -- int12Minor allele frequency- C:0.00NA 4
    rs770580411,2
    C,F--40294868(-) TAATGC/G/TTATCC 1 -- int13NA 6
    rs3686290881,2
    C--40303147(+) TATTT-/CTTTTT 1 -- int10--------
    rs591237661,2
    C--40305967(+) GGACTG/TGGGGG 1 -- int10--------
    rs610421051,2
    C--40370695(+) TCATT-/AT    
       C
    /CAT
    ATATC
    2 -- int1 cds10--------
    rs1879044851,2
    --40380046(+) TATATA/CTATCT 1 -- int10--------
    rs1926646561,2
    --40380050(+) TCTATC/TTATAT 1 -- int10--------
    rs1826678771,2
    C--40381091(+) ATATAA/TTATAT 1 -- int10--------
    rs354005531,2
    C--40424381(+) ACACC-/ACCA  
            
    ACACA
    1 -- int10--------

    HapMap Linkage Disequilibrium report for RTN1 (60062694 - 60312694 bp, first 250kb of RTN1)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for RTN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2656864CNV Deletion23128226
    esv2672267CNV Deletion23128226
    esv2748748CNV Deletion23290073
    esv1643485CNV Deletion17803354
    esv2673231CNV Deletion23128226
    nsv1292CNV Insertion18451855
    esv270586CNV Insertion20981092
    esv1373092CNV Insertion17803354
    nsv901990CNV Loss21882294
    nsv832811CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600865    OMIM disorders: --


    Find genes that share disorders with RTN1           About GenesLikeMe

    Genetic Association Database (GAD): RTN1
    Human Genome Epidemiology (HuGE) Navigator: RTN1 (2 documents)

    Export disorders for RTN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RTN1 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with RTN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Neuronal differentiation is accompanied by NSP-C expression. (PubMed id 9560466)1, 2, 9 Hens J.... Broers J.L. (Cell Tissue Res. 1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Genomic organization of the human NSP gene, prototype of a novel gene family encoding reticulons. (PubMed id 8833145)1, 2 Roebroek A.J.M.... Van de Ven W.J.M. (Genomics 1996)
    5. Regional mapping of the human NSP gene to chromosome region 14q21--&gt;q22 by fluorescence in situ hybridization analysis. (PubMed id 8275708)1, 3 Kools P.F....Van de Ven W.J. (Cytogenet. Cell Genet. 1994)
    6. Cloning and expression of alternative transcripts of a novel neuroendocrine-specific gene and identification of its 135-kDa translational product. (PubMed id 7685762)1, 2 Roebroek A.J.M.... Van de Ven W.J.M. (J. Biol. Chem. 1993)
    7. Cluster-10 lung-cancer antibodies recognize NSPs, novel neuro-endocrine proteins associated with membranes of the endoplasmic reticulum. (PubMed id 7515034)1, 9 Senden N.H....Ramaekers F.C. (Int. J. Cancer Suppl. 1994)
    8. NSP-encoded reticulons are neuroendocrine markers of a novel category in human lung cancer diagnosis. (PubMed id 8062278)1, 9 van de Velde H.J....Van de Ven W.J. (Cancer Res. 1994)
    9. Reticulon proteins: emerging players in neurodegenerative diseases. (PubMed id 16505974)1, 9 Yan R....Zhou X. (Cell. Mol. Life Sci. 2006)
    10. Human reticulon 1-A and 1-B interact with a medium chain of the AP-2 adaptor complex. (PubMed id 14995077)1, 9 Iwahashi J. and Hamada N. (Cell. Mol. Biol. (Noisy-le-grand) 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6252 HGNC: 10467 AceView: RTN1 Ensembl:ENSG00000139970 euGenes: HUgn6252
    ECgene: RTN1 H-InvDB: RTN1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RTN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RTN1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RTN1 gene:
    Search GeneIP for patents involving RTN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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