Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RTL8C Gene

Aliases for RTL8C Gene

  • Retrotransposon Gag Like 8C 2 3
  • Family With Sequence Similarity 127 Member A 2 3 5
  • FAM127A 3 4 5
  • Mammalian Retrotransposon Derived Protein 8C 3 4
  • Sushi-Ichi Retrotransposon Homolog 5 2 3
  • Mammalian Retrotransposon-Derived 8C 2 3
  • CAAX Box 1 2 3
  • Mart8 3 4
  • MAR8C 3 4
  • Mar8 3 4
  • CXX1 3 4
  • Family With Sequence Similarity 127, Member A 2
  • Protein FAM127A 3
  • MART8C 3
  • SIRH5 3

External Ids for RTL8C Gene

Previous HGNC Symbols for RTL8C Gene

  • CXX1
  • FAM127A

Summaries for RTL8C Gene

GeneCards Summary for RTL8C Gene

RTL8C (Retrotransposon Gag Like 8C) is a Protein Coding gene. An important paralog of this gene is RTL8A.

Gene Wiki entry for RTL8C Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTL8C Gene

Genomics for RTL8C Gene

Regulatory Elements for RTL8C Gene

Enhancers for RTL8C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG135031 1 ENCODE 0.7 +0.4 401 2.1 HDGF ATF1 CREB3L1 SIN3A DMAP1 GLI4 ZNF2 YY1 GLIS2 SP3 RTL8B GC0XM135032 RTL8C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RTL8C on UCSC Golden Path with GeneCards custom track

Promoters for RTL8C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000248998 298 2000 HDGF ATF1 CREB3L1 SIN3A DMAP1 GLI4 ZNF2 YY1 GLIS2 SP3

Genomic Location for RTL8C Gene

Chromosome:
X
Start:
135,032,303 bp from pter
End:
135,033,546 bp from pter
Size:
1,244 bases
Orientation:
Plus strand

Genomic View for RTL8C Gene

Genes around RTL8C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTL8C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTL8C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTL8C Gene

Proteins for RTL8C Gene

  • Protein details for RTL8C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6ZKI3-F127A_HUMAN
    Recommended name:
    Protein FAM127A
    Protein Accession:
    A6ZKI3

    Protein attributes for RTL8C Gene

    Size:
    113 amino acids
    Molecular mass:
    13171 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RTL8C Gene

Post-translational modifications for RTL8C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTL8C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RTL8C Gene

Domains & Families for RTL8C Gene

Gene Families for RTL8C Gene

Protein Domains for RTL8C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RTL8C Gene

Graphical View of Domain Structure for InterPro Entry

A6ZKI3

UniProtKB/Swiss-Prot:

F127A_HUMAN :
  • Belongs to the FAM127 family.
Family:
  • Belongs to the FAM127 family.
genes like me logo Genes that share domains with RTL8C: view

Function for RTL8C Gene

genes like me logo Genes that share phenotypes with RTL8C: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RTL8C Gene

Localization for RTL8C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTL8C gene
Compartment Confidence
mitochondrion 2
extracellular 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RTL8C Gene

Pathways & Interactions for RTL8C Gene

SuperPathways for RTL8C Gene

No Data Available

Gene Ontology (GO) - Biological Process for RTL8C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RTL8C Gene

Drugs & Compounds for RTL8C Gene

No Compound Related Data Available

Transcripts for RTL8C Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTL8C Gene

No ASD Table

Relevant External Links for RTL8C Gene

GeneLoc Exon Structure for
RTL8C
ECgene alternative splicing isoforms for
RTL8C

Expression for RTL8C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of RTL8C Gene:

RTL8C

Evidence on tissue expression from TISSUES for RTL8C Gene

  • Nervous system(3.8)
  • Muscle(2.9)
  • Lung(2.7)
  • Heart(2.5)
  • Skin(2.5)
  • Eye(2.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with RTL8C: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTL8C Gene

Orthologs for RTL8C Gene

This gene was present in the common ancestor of mammals.

Orthologs for RTL8C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM127A 34 35
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia LOC100683463 34
  • 91.45 (n)
-- 35
  • 87 (a)
ManyToMany
-- 35
  • 87 (a)
ManyToMany
-- 35
  • 87 (a)
ManyToMany
-- 35
  • 87 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia FAM127A 35 35 35
  • 90 (a)
ManyToMany
FAM127C 34
  • 89.68 (n)
mouse
(Mus musculus)
Mammalia Cxx1c 34 16
  • 73.57 (n)
Cxx1b 35
  • 71 (a)
ManyToMany
Species where no ortholog for RTL8C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RTL8C Gene

ENSEMBL:
Gene Tree for RTL8C (if available)
TreeFam:
Gene Tree for RTL8C (if available)

Paralogs for RTL8C Gene

Paralogs for RTL8C Gene

genes like me logo Genes that share paralogs with RTL8C: view

Variants for RTL8C Gene

Sequence variations from dbSNP and Humsavar for RTL8C Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1002500077 -- 135,032,061(+) CCCCG(C/T)ACACC upstream-variant-2KB
rs1005620804 -- 135,033,979(+) TTTAA(C/T)TGGGT downstream-variant-500B
rs1006304346 -- 135,031,980(+) GGGAC(C/G/T)AGTGC upstream-variant-2KB
rs1006397701 -- 135,031,373(+) TGTGA(A/G)CTGCC upstream-variant-2KB
rs1007148345 -- 135,032,811(+) GCGCC(C/T)TCCCT utr-variant-3-prime

Variation tolerance for RTL8C Gene

Residual Variation Intolerance Score: 40.5% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RTL8C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RTL8C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RTL8C Gene

Disorders for RTL8C Gene

Relevant External Links for RTL8C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RTL8C

No disorders were found for RTL8C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RTL8C Gene

Publications for RTL8C Gene

  1. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. (PMID: 15716091) Brandt J. … Volff J.-N. (Gene 2005) 2 3 4 64
  2. A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes. (PMID: 16093683) Brandt J. … Volff J.-N. (Cytogenet. Genome Res. 2005) 2 3 4 64
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. A low-copy repeat in Xq26 represents a novel putatively prenylated protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and DXS9916). (PMID: 9403077) Frattini A. … Vezzoni P. (Genomics 1997) 2 3 64

Products for RTL8C Gene

Sources for RTL8C Gene

Content
Loading form....