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Aliases for RTL8B Gene

Aliases for RTL8B Gene

  • Retrotransposon Gag Like 8B 2 3
  • Family With Sequence Similarity 127 Member C 2 3 5
  • FAM127C 3 4 5
  • Mammalian Retrotransposon Derived Protein 8B 3 4
  • Sushi-Ichi Retrotransposon Homolog 1 2 3
  • Mammalian Retrotransposon-Derived 2 2 3
  • CXX1c 3 4
  • MAR8B 3 4
  • Family With Sequence Similarity 127, Member C 2
  • Protein FAM127C 3
  • SIRH4 3

External Ids for RTL8B Gene

Previous HGNC Symbols for RTL8B Gene

  • FAM127C

Summaries for RTL8B Gene

GeneCards Summary for RTL8B Gene

RTL8B (Retrotransposon Gag Like 8B) is a Protein Coding gene. An important paralog of this gene is RTL8A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTL8B Gene

Genomics for RTL8B Gene

Regulatory Elements for RTL8B Gene

Enhancers for RTL8B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG135003 1.5 FANTOM5 Ensembl ENCODE 16.5 +18.3 18283 1.3 HDAC1 TBP HDGF PKNOX1 ATF1 SIN3A FEZF1 GLIS2 ELK1 EGR1 RTL8B SMIM10
GH0XG134989 1.3 Ensembl ENCODE 16.4 +31.4 31376 2.4 ATF1 CREB3L1 E2F7 GLI4 ZNF2 ZNF121 ZNF766 GLIS2 ELK1 KLF7 RTL8B SMIM10
GH0XG135020 0.9 ENCODE 17.9 +0.2 227 2.7 HDGF PKNOX1 SIN3A ZNF2 GLIS2 KLF7 SP3 TSHZ1 REST ZNF592 RTL8B SMIM10
GH0XG135050 1 ENCODE 15.6 -29.4 -29386 2.0 HDGF CREB3L1 AGO1 SIN3A ZNF2 ZNF263 SP3 REST ZNF592 CBX8 RTL8B GC0XM135053 RTL8A GC0XM135055
GH0XG135031 1 ENCODE 15.4 -10.2 -10168 2.1 HDGF ATF1 CREB3L1 SIN3A DMAP1 GLI4 ZNF2 YY1 GLIS2 SP3 RTL8B RTL8C GC0XM135032
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RTL8B on UCSC Golden Path with GeneCards custom track

Promoters for RTL8B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000248997 335 1599 HDGF PKNOX1 SIN3A ZNF2 GLIS2 KLF7 SP3 TSHZ1 REST ZNF592

Genomic Location for RTL8B Gene

Chromosome:
X
Start:
135,020,504 bp from pter
End:
135,022,536 bp from pter
Size:
2,033 bases
Orientation:
Minus strand

Genomic View for RTL8B Gene

Genes around RTL8B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTL8B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTL8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTL8B Gene

Proteins for RTL8B Gene

  • Protein details for RTL8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q17RB0-F127C_HUMAN
    Recommended name:
    Protein FAM127C
    Protein Accession:
    Q17RB0

    Protein attributes for RTL8B Gene

    Size:
    113 amino acids
    Molecular mass:
    13246 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RTL8B Gene

Post-translational modifications for RTL8B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTL8B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RTL8B Gene

Domains & Families for RTL8B Gene

Gene Families for RTL8B Gene

Protein Domains for RTL8B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RTL8B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q17RB0

UniProtKB/Swiss-Prot:

F127C_HUMAN :
  • Belongs to the FAM127 family.
Family:
  • Belongs to the FAM127 family.
genes like me logo Genes that share domains with RTL8B: view

Function for RTL8B Gene

Gene Ontology (GO) - Molecular Function for RTL8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RTL8B: view

Phenotypes for RTL8B Gene

GenomeRNAi human phenotypes for RTL8B:
genes like me logo Genes that share phenotypes with RTL8B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RTL8B Gene

Localization for RTL8B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTL8B gene
Compartment Confidence
mitochondrion 3
peroxisome 2
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RTL8B Gene

Pathways & Interactions for RTL8B Gene

SuperPathways for RTL8B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RTL8B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RTL8B Gene

Drugs & Compounds for RTL8B Gene

No Compound Related Data Available

Transcripts for RTL8B Gene

mRNA/cDNA for RTL8B Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTL8B Gene

No ASD Table

Relevant External Links for RTL8B Gene

GeneLoc Exon Structure for
RTL8B
ECgene alternative splicing isoforms for
RTL8B

Expression for RTL8B Gene

NURSA nuclear receptor signaling pathways regulating expression of RTL8B Gene:

RTL8B
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTL8B Gene

Orthologs for RTL8B Gene

This gene was present in the common ancestor of mammals.

Orthologs for RTL8B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM127C 34
  • 98.53 (n)
cow
(Bos Taurus)
Mammalia FAM127A 35 35 35
  • 86 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 81 (a)
ManyToMany
-- 35
  • 81 (a)
ManyToMany
-- 35
  • 81 (a)
ManyToMany
-- 35
  • 81 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cxx1a 34 35
  • 78.79 (n)
Cxx1b 16 35
  • 70 (a)
Cxx1c 35
  • 61 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC679038 34
  • 78.79 (n)
Species where no ortholog for RTL8B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RTL8B Gene

ENSEMBL:
Gene Tree for RTL8B (if available)
TreeFam:
Gene Tree for RTL8B (if available)

Paralogs for RTL8B Gene

Paralogs for RTL8B Gene

genes like me logo Genes that share paralogs with RTL8B: view

Variants for RTL8B Gene

Sequence variations from dbSNP and Humsavar for RTL8B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1003712125 -- 135,022,734(+) GTGGG(G/T)CAAAG upstream-variant-2KB
rs1004664595 -- 135,023,183(+) TTCCG(A/G)AACAT upstream-variant-2KB
rs1004973921 -- 135,023,691(+) GCAAT(A/G)GTGGG upstream-variant-2KB
rs1005805929 -- 135,021,677(+) TGTCG(A/G)TGGAA utr-variant-3-prime
rs1006555795 -- 135,024,216(+) GTTAA(A/G)GCATA upstream-variant-2KB

Variation tolerance for RTL8B Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RTL8B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RTL8B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RTL8B Gene

Disorders for RTL8B Gene

Relevant External Links for RTL8B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RTL8B

No disorders were found for RTL8B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RTL8B Gene

Publications for RTL8B Gene

  1. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. (PMID: 15716091) Brandt J. … Volff J.-N. (Gene 2005) 2 3 64
  2. A low-copy repeat in Xq26 represents a novel putatively prenylated protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and DXS9916). (PMID: 9403077) Frattini A. … Vezzoni P. (Genomics 1997) 2 3 64
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for RTL8B Gene

Sources for RTL8B Gene

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