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Aliases for RTL8A Gene

Aliases for RTL8A Gene

  • Retrotransposon Gag Like 8A 2 3
  • Family With Sequence Similarity 127 Member B 2 3 5
  • FAM127B 3 4 5
  • Mammalian Retrotransposon Derived Protein 8A 3 4
  • Sushi-Ichi Retrotransposon Homolog 6 2 3
  • Mammalian Retrotransposon-Derived 8A 2 3
  • CXX1b 3 4
  • MAR8A 3 4
  • Family With Sequence Similarity 127, Member B 2
  • Protein FAM127B 3
  • SIRH6 3

External Ids for RTL8A Gene

Previous HGNC Symbols for RTL8A Gene

  • FAM127B

Summaries for RTL8A Gene

GeneCards Summary for RTL8A Gene

RTL8A (Retrotransposon Gag Like 8A) is a Protein Coding gene. An important paralog of this gene is RTL8B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTL8A Gene

Genomics for RTL8A Gene

Regulatory Elements for RTL8A Gene

Enhancers for RTL8A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG135098 0.8 ENCODE 10.3 -46.7 -46720 0.2 PKNOX1 ATF1 KAT2B ZNF366 EGR1 CREM EGR2 SP3 SP5 SP1 RTL8A SMIM10L2B ETDB
GH0XG134965 1 Ensembl ENCODE 7.9 +86.7 86695 0.6 CTCF ZNF654 ZNF362 USF2 ZNF384 REST RAD21 ZNF664 ZNF121 GATA3 SMIM10 RTL8A HMGB3P31
GH0XG135050 1 ENCODE 0.7 +0.3 275 2.0 HDGF CREB3L1 AGO1 SIN3A ZNF2 ZNF263 SP3 REST ZNF592 CBX8 RTL8B GC0XM135053 GC0XM135055 RTL8A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RTL8A on UCSC Golden Path with GeneCards custom track

Promoters for RTL8A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000248999 296 1800 HDGF CREB3L1 AGO1 SIN3A ZNF2 ZNF263 SP3 REST ZNF592 CBX8

Genomic Location for RTL8A Gene

Chromosome:
X
Start:
135,050,932 bp from pter
End:
135,052,196 bp from pter
Size:
1,265 bases
Orientation:
Minus strand

Genomic View for RTL8A Gene

Genes around RTL8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTL8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTL8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTL8A Gene

Proteins for RTL8A Gene

  • Protein details for RTL8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWD3-F127B_HUMAN
    Recommended name:
    Protein FAM127B
    Protein Accession:
    Q9BWD3
    Secondary Accessions:
    • A2A2V9
    • Q8TBU2

    Protein attributes for RTL8A Gene

    Size:
    113 amino acids
    Molecular mass:
    13188 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RTL8A Gene

Post-translational modifications for RTL8A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTL8A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RTL8A Gene

Domains & Families for RTL8A Gene

Gene Families for RTL8A Gene

Protein Domains for RTL8A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RTL8A Gene

Graphical View of Domain Structure for InterPro Entry

Q9BWD3

UniProtKB/Swiss-Prot:

F127B_HUMAN :
  • Belongs to the FAM127 family.
Family:
  • Belongs to the FAM127 family.
genes like me logo Genes that share domains with RTL8A: view

Function for RTL8A Gene

Gene Ontology (GO) - Molecular Function for RTL8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with RTL8A: view
genes like me logo Genes that share phenotypes with RTL8A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RTL8A Gene

Localization for RTL8A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTL8A gene
Compartment Confidence
mitochondrion 2
cytosol 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RTL8A Gene

Pathways & Interactions for RTL8A Gene

SuperPathways for RTL8A Gene

No Data Available

Interacting Proteins for RTL8A Gene

Gene Ontology (GO) - Biological Process for RTL8A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RTL8A Gene

Transcripts for RTL8A Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTL8A Gene

No ASD Table

Relevant External Links for RTL8A Gene

GeneLoc Exon Structure for
RTL8A
ECgene alternative splicing isoforms for
RTL8A

Expression for RTL8A Gene

NURSA nuclear receptor signaling pathways regulating expression of RTL8A Gene:

RTL8A
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTL8A Gene

Orthologs for RTL8A Gene

This gene was present in the common ancestor of mammals.

Orthologs for RTL8A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM127B 34 35
  • 98.53 (n)
cow
(Bos Taurus)
Mammalia FAM127A 35 35 35
  • 88 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 84 (a)
ManyToMany
-- 35
  • 84 (a)
ManyToMany
-- 35
  • 84 (a)
ManyToMany
-- 35
  • 84 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cxx1a 35
  • 69 (a)
ManyToMany
Cxx1b 35
  • 69 (a)
ManyToMany
Cxx1c 35
  • 63 (a)
ManyToMany
Species where no ortholog for RTL8A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RTL8A Gene

ENSEMBL:
Gene Tree for RTL8A (if available)
TreeFam:
Gene Tree for RTL8A (if available)

Paralogs for RTL8A Gene

Paralogs for RTL8A Gene

genes like me logo Genes that share paralogs with RTL8A: view

Variants for RTL8A Gene

Sequence variations from dbSNP and Humsavar for RTL8A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000679334 -- 135,050,683(+) TTGGC(C/T)AAAAT downstream-variant-500B
rs1004861671 -- 135,051,465(+) AGGAG(C/T)CCAGC intron-variant, utr-variant-3-prime
rs1005529590 -- 135,053,538(+) GTTAA(C/T)TTTCT upstream-variant-2KB
rs1005715241 -- 135,052,409(+) GTGGG(G/T)CTCTC upstream-variant-2KB
rs1006914166 -- 135,050,765(+) GTTGC(C/T)GATAA downstream-variant-500B

Variation tolerance for RTL8A Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RTL8A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RTL8A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RTL8A Gene

Disorders for RTL8A Gene

Relevant External Links for RTL8A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RTL8A

No disorders were found for RTL8A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RTL8A Gene

Publications for RTL8A Gene

  1. Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. (PMID: 15716091) Brandt J. … Volff J.-N. (Gene 2005) 2 3 64
  2. A low-copy repeat in Xq26 represents a novel putatively prenylated protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and DXS9916). (PMID: 9403077) Frattini A. … Vezzoni P. (Genomics 1997) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64

Products for RTL8A Gene

Sources for RTL8A Gene

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