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Aliases for RTL10 Gene

Aliases for RTL10 Gene

  • Retrotransposon Gag Like 10 2 3
  • BH3-Only Protein 2 3 4
  • C22orf29 3 4 5
  • Chromosome 22 Open Reading Frame 29 2 5
  • BOP 3 4
  • Protein Bop 3

External Ids for RTL10 Gene

Previous HGNC Symbols for RTL10 Gene

  • C22orf29

Summaries for RTL10 Gene

GeneCards Summary for RTL10 Gene

RTL10 (Retrotransposon Gag Like 10) is a Protein Coding gene. Diseases associated with RTL10 include Hemophagocytic Lymphohistiocytosis, Familial, 3 and Wolfram Syndrome 2.

UniProtKB/Swiss-Prot for RTL10 Gene

  • Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTL10 Gene

Genomics for RTL10 Gene

Regulatory Elements for RTL10 Gene

Enhancers for RTL10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G019852 1.4 ENCODE dbSUPER 12.8 -0.2 -153 4.8 HDGF FOXA2 MLX AGO1 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 TXNRD2 RTL10 ABHD17AP4 GNB1L RPL8P5 GC22P019862
GH22G019429 1.4 ENCODE dbSUPER 11.8 +423.1 423123 4.7 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 LINC01311 DGCR8 UFD1 RPL7AP70 ENSG00000273300 DGCR11 RTL10 ENSG00000273343 DGCR14 CLTCL1
GH22G019780 1.3 Ensembl ENCODE 10.3 +74.4 74384 1.2 HNRNPUL1 HDGF ATF1 FOXA2 PKNOX1 CREB3L1 ARNT SIN3A ZNF766 ELK1 TBX1 RTL10 RPL7AP70 RPL8P5
GH22G019874 2 FANTOM5 Ensembl ENCODE dbSUPER 6.3 -24.0 -24022 9.7 PKNOX1 FOXA2 AGO1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 FOS TXNRD2 RPL8P5 ENSG00000273343 LINC01311 LOC100420177 GNB1L RTL10 DGCR6L COMT ZDHHC8
GH22G019884 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.5 -31.8 -31754 5.1 ATF1 PKNOX1 AGO1 FEZF1 ZNF2 ZNF766 GLIS2 GATA2 KLF7 FOS TXNRD2 LINC01311 LOC100420177 RPL8P5 DGCR8 GNB1L RTL10 COMT TRMT2A GC22M019875
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RTL10 on UCSC Golden Path with GeneCards custom track

Promoters for RTL10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000143807 48 2001 HDGF MLX AGO1 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF143

Genomic Location for RTL10 Gene

Chromosome:
22
Start:
19,846,138 bp from pter
End:
19,854,896 bp from pter
Size:
8,759 bases
Orientation:
Minus strand

Genomic View for RTL10 Gene

Genes around RTL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTL10 Gene

Proteins for RTL10 Gene

  • Protein details for RTL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L3V2-BOP_HUMAN
    Recommended name:
    Protein Bop
    Protein Accession:
    Q7L3V2
    Secondary Accessions:
    • A8K5E7
    • D3DX21
    • Q6MZM8
    • Q6N000
    • Q9H7A0

    Protein attributes for RTL10 Gene

    Size:
    364 amino acids
    Molecular mass:
    39299 Da
    Quaternary structure:
    • Interacts (via BH3 domain) with VDAC1. Interacts with pro-survival Bcl-2 family members, BCL2, BCL2L1 isoform Bcl-X(L), MCL1, BCL2A1 and BCL2L2. Interacts with BAX and BAK.
    • Interacts (via BH3 domain) with VDAC1. Interacts with pro-survival Bcl-2 family members, BCL2, BCL2L1 isoform Bcl-X(L), MCL1, BCL2A1 and BCL2L2. Interacts with BAX and BAK.
    SequenceCaution:
    • Sequence=BAB14998.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for RTL10 Gene

Post-translational modifications for RTL10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTL10 Gene

No data available for DME Specific Peptides for RTL10 Gene

Domains & Families for RTL10 Gene

Protein Domains for RTL10 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7L3V2

UniProtKB/Swiss-Prot:

BOP_HUMAN :
  • The BH3 motif is required for pro-apoptotic activity and for interaction with pro-survival Bcl-2 family members.
Domain:
  • The BH3 motif is required for pro-apoptotic activity and for interaction with pro-survival Bcl-2 family members.
genes like me logo Genes that share domains with RTL10: view

No data available for Suggested Antigen Peptide Sequences for RTL10 Gene

Function for RTL10 Gene

Molecular function for RTL10 Gene

UniProtKB/Swiss-Prot Function:
Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity.

Gene Ontology (GO) - Molecular Function for RTL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23055042
genes like me logo Genes that share ontologies with RTL10: view
genes like me logo Genes that share phenotypes with RTL10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RTL10 Gene

Localization for RTL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTL10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTL10 gene
Compartment Confidence
mitochondrion 5
cytosol 3
nucleus 2
endoplasmic reticulum 2
cytoskeleton 1
lysosome 1

Gene Ontology (GO) - Cellular Components for RTL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 23055042
genes like me logo Genes that share ontologies with RTL10: view

Pathways & Interactions for RTL10 Gene

SuperPathways for RTL10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RTL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0051881 regulation of mitochondrial membrane potential IEA,IMP 23055042
GO:0097345 mitochondrial outer membrane permeabilization IMP,IEA 23055042
genes like me logo Genes that share ontologies with RTL10: view

No data available for Pathways by source and SIGNOR curated interactions for RTL10 Gene

Drugs & Compounds for RTL10 Gene

No Compound Related Data Available

Transcripts for RTL10 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTL10 Gene

No ASD Table

Relevant External Links for RTL10 Gene

GeneLoc Exon Structure for
RTL10
ECgene alternative splicing isoforms for
RTL10

Expression for RTL10 Gene

NURSA nuclear receptor signaling pathways regulating expression of RTL10 Gene:

RTL10

mRNA Expression by UniProt/SwissProt for RTL10 Gene:

Q7L3V2-BOP_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for RTL10 Gene

  • Nervous system(2.1)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTL10 Gene

Orthologs for RTL10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RTL10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C22H22orf29 34
  • 98.63 (n)
C22H22ORF29 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C26H22orf29 34
  • 73.38 (n)
mouse
(Mus musculus)
Mammalia Gm16314 35
  • 33 (a)
OneToOne
Species where no ortholog for RTL10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RTL10 Gene

ENSEMBL:
Gene Tree for RTL10 (if available)
TreeFam:
Gene Tree for RTL10 (if available)

Paralogs for RTL10 Gene

No data available for Paralogs for RTL10 Gene

Variants for RTL10 Gene

Sequence variations from dbSNP and Humsavar for RTL10 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000368319 -- 19,855,966(+) CCTGG(C/T)CCAGT upstream-variant-2KB
rs1000384144 -- 19,850,952(+) CCAGC(A/G)GCAGG intron-variant, utr-variant-3-prime
rs1000392784 -- 19,848,489(+) GAGCT(G/T)TGTGC intron-variant, utr-variant-3-prime
rs1000420615 -- 19,855,741(+) TTCTC(A/C/G)CTTGC upstream-variant-2KB
rs1000758585 -- 19,847,502(+) ATGAG(A/G)AAAAA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RTL10 Gene

Variant ID Type Subtype PubMed ID
dgv7983n54 CNV gain 21841781
esv3568260 CNV loss 25503493
esv3575418 CNV gain 25503493
esv3647279 CNV gain 21293372
esv3893434 CNV gain 25118596
nsv828938 CNV gain 20364138
nsv828939 CNV loss 20364138
nsv828949 CNV gain 20364138
nsv834129 CNV loss 17160897
nsv834130 CNV loss 17160897
nsv953024 CNV deletion 24416366

Variation tolerance for RTL10 Gene

Residual Variation Intolerance Score: 85.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RTL10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RTL10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTL10 Gene

Disorders for RTL10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RTL10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hemophagocytic lymphohistiocytosis, familial, 3
  • familial hemophagocytic lymphohistiocytosis 3
wolfram syndrome 2
  • wfs2
- elite association - COSMIC cancer census association via MalaCards
Search RTL10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RTL10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RTL10
genes like me logo Genes that share disorders with RTL10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RTL10 Gene

Publications for RTL10 Gene

  1. Human Bop is a novel BH3-only member of the Bcl-2 protein family. (PMID: 23055042) Zhang X. … Tang H. (Protein Cell 2012) 2 3 4 64
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  3. BH3-only proteins: possible proapoptotic triggers for melanoma therapy. (PMID: 24673301) PlAPtz M. … Eberle J. (Exp. Dermatol. 2014) 3 64
  4. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. (PMID: 25184681) Hill S.J. … Livingston D.M. (Genes Dev. 2014) 3 64
  5. [Effect and significance of BH3-only protein in targeted therapy ofa8c non-small cell lung cancer]. (PMID: 25404273) Gao W. … Liu K. (Zhongguo Fei Ai Za Zhi 2014) 3 64

Products for RTL10 Gene

Sources for RTL10 Gene

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