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Aliases for RTKN2 Gene

Aliases for RTKN2 Gene

  • Rhotekin 2 2 3 5
  • Pleckstrin Homology Domain-Containing Family K Member 1 3 4
  • PH Domain-Containing Family K Member 1 3 4
  • PLEKHK1 3 4
  • Pleckstrin Homology Domain Containing, Family K Member 1 2
  • BA531F24.1 3
  • Rhotekin-2 3

External Ids for RTKN2 Gene

Previous HGNC Symbols for RTKN2 Gene


Previous GeneCards Identifiers for RTKN2 Gene

  • GC10M063035
  • GC10M063835
  • GC10M063613
  • GC10M063942
  • GC10M057942

Summaries for RTKN2 Gene

GeneCards Summary for RTKN2 Gene

RTKN2 (Rhotekin 2) is a Protein Coding gene. An important paralog of this gene is RTKN.

UniProtKB/Swiss-Prot for RTKN2 Gene

  • May play an important role in lymphopoiesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTKN2 Gene

Genomics for RTKN2 Gene

Regulatory Elements for RTKN2 Gene

Enhancers for RTKN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F062264 1.5 FANTOM5 Ensembl ENCODE 11.6 +3.8 3787 1.5 CTCF TEAD4 SIN3A ZNF384 CEBPG FEZF1 BCL11B RAD21 ZNF101 RFX5 RTKN2 ZNF365 ARID5B LOC105378325
GH10F062242 1.5 FANTOM5 Ensembl ENCODE 11.2 +24.4 24367 4.2 PKNOX1 SIN3A ZNF2 CBX5 ZNF143 FOS JUNB REST TBX21 PPARG ARID5B RTKN2 ZNF365 LOC105378325
GH10F061759 1.4 Ensembl ENCODE 9.8 +506.1 506051 7.5 HDGF PKNOX1 ARNT CREB3L1 SIN3A DMAP1 FEZF1 ZNF2 ZNF766 CBX5 ARID5B RTKN2 C10orf107 GC10P061754 ENSG00000233643
GH10F062267 1 ENCODE 12.7 +0.2 234 1.8 MLX ARID4B SIN3A DMAP1 ZNF48 GLIS2 ELK1 SP3 SP5 NFYC RTKN2 ZNF365 LOC105378325
GH10F062230 1 Ensembl ENCODE 12.4 +35.3 35274 6.3 ZNF362 JUN CEBPB MAFG EP300 OSR2 SREBF1 JUND MAFF ZNF316 RTKN2 ZNF365 LOC105378325 LOC105378326
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RTKN2 on UCSC Golden Path with GeneCards custom track

Promoters for RTKN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004743 263 2001 MLX ARID4B SIN3A DMAP1 ZNF48 GLIS2 ELK1 SP3 SP5 MXD4

Genomic Location for RTKN2 Gene

62,183,035 bp from pter
62,268,863 bp from pter
85,829 bases
Minus strand

Genomic View for RTKN2 Gene

Genes around RTKN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTKN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTKN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTKN2 Gene

Proteins for RTKN2 Gene

  • Protein details for RTKN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q3ZCR1
    • Q68DZ6
    • Q8N8K1
    • Q8TAV2

    Protein attributes for RTKN2 Gene

    609 amino acids
    Molecular mass:
    69304 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04837.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BC048002; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for RTKN2 Gene


neXtProt entry for RTKN2 Gene

Post-translational modifications for RTKN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RTKN2 Gene

Domains & Families for RTKN2 Gene

Gene Families for RTKN2 Gene

Suggested Antigen Peptide Sequences for RTKN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PH domain.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with RTKN2: view

Function for RTKN2 Gene

Molecular function for RTKN2 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in lymphopoiesis.
UniProtKB/Swiss-Prot Induction:
Up-regulated in cells resistant to 25-hydroxy cholesterol (25-OHC). Down-regulated in lymphocytes activated by treatment with phytohemagglutinin (PHA).
genes like me logo Genes that share phenotypes with RTKN2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RTKN2 Gene

Localization for RTKN2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTKN2 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RTKN2 Gene

Pathways & Interactions for RTKN2 Gene

SuperPathways for RTKN2 Gene

No Data Available

Interacting Proteins for RTKN2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8IZC4-RTKN2_HUMAN ENSP00000362894 for RTKN2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for RTKN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0030097 hemopoiesis IEA --
genes like me logo Genes that share ontologies with RTKN2: view

No data available for Pathways by source and SIGNOR curated interactions for RTKN2 Gene

Transcripts for RTKN2 Gene

Unigene Clusters for RTKN2 Gene

Rhotekin 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTKN2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - - - -
SP2: -
SP4: -

Relevant External Links for RTKN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RTKN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RTKN2 Gene

mRNA differential expression in normal tissues according to GTEx for RTKN2 Gene

This gene is overexpressed in Lung (x19.3), Esophagus - Mucosa (x6.9), and Testis (x4.1).

Protein differential expression in normal tissues from HIPED for RTKN2 Gene

This gene is overexpressed in Esophagus (34.0) and Fetal Brain (33.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RTKN2 Gene

Protein tissue co-expression partners for RTKN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RTKN2 Gene:


SOURCE GeneReport for Unigene cluster for RTKN2 Gene:


mRNA Expression by UniProt/SwissProt for RTKN2 Gene:

Tissue specificity: Expressed in lymphocytes, CD4 positive T-cells and bone marrow-derived cells. Also expressed in lung, colon, thymus and brain.
genes like me logo Genes that share expression patterns with RTKN2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RTKN2 Gene

Orthologs for RTKN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RTKN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RTKN2 34 35
  • 99.73 (n)
(Canis familiaris)
Mammalia RTKN2 34 35
  • 90.18 (n)
(Bos Taurus)
Mammalia RTKN2 34 35
  • 88.85 (n)
(Mus musculus)
Mammalia Rtkn2 34 16 35
  • 77.44 (n)
(Rattus norvegicus)
Mammalia Rtkn2 34
  • 75.23 (n)
(Ornithorhynchus anatinus)
Mammalia RTKN2 35
  • 73 (a)
(Monodelphis domestica)
Mammalia RTKN2 35
  • 57 (a)
(Gallus gallus)
Aves RTKN2 34 35
  • 73.12 (n)
(Anolis carolinensis)
Reptilia RTKN2 35
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rtkn2 34
  • 66.33 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32514 34
(Danio rerio)
Actinopterygii rtkn2a 34 35
  • 58.89 (n)
wufl63a03 34
(Caenorhabditis elegans)
Secernentea C07B5.4 35
  • 20 (a)
Species where no ortholog for RTKN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RTKN2 Gene

Gene Tree for RTKN2 (if available)
Gene Tree for RTKN2 (if available)

Paralogs for RTKN2 Gene

Paralogs for RTKN2 Gene

(1) SIMAP similar genes for RTKN2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RTKN2: view

Variants for RTKN2 Gene

Sequence variations from dbSNP and Humsavar for RTKN2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1007976 -- 62,210,385(+) ACACA(C/T)GGGTT intron-variant
rs10615822 -- 62,165,439(+) TTTTT(-/T)GAGAC intron-variant
rs10617828 -- 62,211,775(+) CCTGC(-/CTTA)CTTAG intron-variant
rs10637134 -- 62,221,594(+) AACAC(-/TTAC)ATGCA intron-variant
rs10639375 -- 62,234,495(+) TCTTA(-/AA)AAAAA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RTKN2 Gene

Variant ID Type Subtype PubMed ID
nsv8681 CNV gain 18304495
nsv831890 CNV gain 17160897
nsv6831 CNV insertion 18451855
nsv551179 CNV loss 21841781
nsv467292 CNV loss 19166990
esv34099 CNV loss 18971310
esv2737551 CNV deletion 23290073
esv2737540 CNV deletion 23290073
dgv1201n54 CNV loss 21841781

Variation tolerance for RTKN2 Gene

Residual Variation Intolerance Score: 41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.14; 87.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RTKN2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTKN2 Gene

Disorders for RTKN2 Gene

Relevant External Links for RTKN2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RTKN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RTKN2 Gene

Publications for RTKN2 Gene

  1. Identification and characterization of a lymphocytic Rho-GTPase effector: rhotekin-2. (PMID: 15504364) Collier F.M. … Kirkland M.A. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 22 64
  2. Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C. … Munroe P.B. (Nat. Genet. 2009) 3 46 64
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells. (PMID: 15120425) Gregorio-King C.C. … Kirkland M.A. (J. Steroid Biochem. Mol. Biol. 2004) 3 4 64

Products for RTKN2 Gene

Sources for RTKN2 Gene

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