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Aliases for RTKN2 Gene

Aliases for RTKN2 Gene

  • Rhotekin 2 2 3 5
  • Pleckstrin Homology Domain-Containing Family K Member 1 3 4
  • PH Domain-Containing Family K Member 1 3 4
  • PLEKHK1 3 4
  • Pleckstrin Homology Domain Containing, Family K Member 1 2
  • BA531F24.1 3
  • Rhotekin-2 3

External Ids for RTKN2 Gene

Previous HGNC Symbols for RTKN2 Gene

  • PLEKHK1

Previous GeneCards Identifiers for RTKN2 Gene

  • GC10M063035
  • GC10M063835
  • GC10M063613
  • GC10M063942
  • GC10M057942

Summaries for RTKN2 Gene

GeneCards Summary for RTKN2 Gene

RTKN2 (Rhotekin 2) is a Protein Coding gene. An important paralog of this gene is RTKN.

UniProtKB/Swiss-Prot for RTKN2 Gene

  • May play an important role in lymphopoiesis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTKN2 Gene

Genomics for RTKN2 Gene

Regulatory Elements for RTKN2 Gene

Enhancers for RTKN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G062242 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +24.4 24367 4.2 PKNOX1 FOXA2 SIN3A ZNF2 YY1 GATA2 CBX5 ZNF143 FOS DEK ARID5B RTKN2 ZNF365 LOC105378325
GH10G062264 1.4 FANTOM5 Ensembl ENCODE 11.6 +3.8 3787 1.5 SIN3A FEZF1 ZBTB40 RAD21 RFX5 ZNF366 RCOR1 ZNF654 NFYA CEBPB RTKN2 ZNF365 ARID5B LOC105378325
GH10G062230 1.2 Ensembl ENCODE dbSUPER 12.4 +35.3 35274 6.3 ARNT JUN ZNF316 FOS MAFK ZNF362 MAFG CEBPB EP300 SREBF1 RTKN2 ZNF365 LOC105378325 LOC105378326
GH10G062267 1 ENCODE 12.7 +0.2 234 1.8 MLX ARID4B SIN3A DMAP1 ZNF48 GLIS2 ELK1 SP3 SP5 ZHX2 RTKN2 ZNF365 LOC105378325
GH10G062249 1.4 FANTOM5 Ensembl ENCODE 7.6 +17.8 17757 2.9 SOX13 FOXA2 ZNF133 ZNF664 POLR3A POLR2A ZNF366 ZNF239 ZNF600 FOS ZNF365 RTKN2 ARID5B LOC105378325
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RTKN2 on UCSC Golden Path with GeneCards custom track

Promoters for RTKN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000028779 163 1800 MLX ARID4B SIN3A DMAP1 ZNF48 GLIS2 ELK1 SP3 SP5 ZHX2

Genomic Location for RTKN2 Gene

Chromosome:
10
Start:
62,183,035 bp from pter
End:
62,268,863 bp from pter
Size:
85,829 bases
Orientation:
Minus strand

Genomic View for RTKN2 Gene

Genes around RTKN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTKN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTKN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTKN2 Gene

Proteins for RTKN2 Gene

  • Protein details for RTKN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZC4-RTKN2_HUMAN
    Recommended name:
    Rhotekin-2
    Protein Accession:
    Q8IZC4
    Secondary Accessions:
    • Q3ZCR1
    • Q68DZ6
    • Q8N8K1
    • Q8TAV2

    Protein attributes for RTKN2 Gene

    Size:
    609 amino acids
    Molecular mass:
    69304 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04837.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BC048002; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for RTKN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RTKN2 Gene

Post-translational modifications for RTKN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RTKN2 Gene

Domains & Families for RTKN2 Gene

Gene Families for RTKN2 Gene

Suggested Antigen Peptide Sequences for RTKN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RTKN2: view

No data available for UniProtKB/Swiss-Prot for RTKN2 Gene

Function for RTKN2 Gene

Molecular function for RTKN2 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in lymphopoiesis.
UniProtKB/Swiss-Prot Induction:
Up-regulated in cells resistant to 25-hydroxy cholesterol (25-OHC). Down-regulated in lymphocytes activated by treatment with phytohemagglutinin (PHA).
genes like me logo Genes that share phenotypes with RTKN2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RTKN2 Gene

Localization for RTKN2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTKN2 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RTKN2 Gene

Pathways & Interactions for RTKN2 Gene

SuperPathways for RTKN2 Gene

No Data Available

Interacting Proteins for RTKN2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000362894%0d%0a9606.ENSP00000338671%0d%0a
Selected Interacting proteins: ENSP00000362894 Q8IZC4-RTKN2_HUMAN for RTKN2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for RTKN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0030097 hemopoiesis IEA --
genes like me logo Genes that share ontologies with RTKN2: view

No data available for Pathways by source and SIGNOR curated interactions for RTKN2 Gene

Drugs & Compounds for RTKN2 Gene

No Compound Related Data Available

Transcripts for RTKN2 Gene

Unigene Clusters for RTKN2 Gene

Rhotekin 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTKN2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - - - -
SP2: -
SP3:
SP4: -
SP5:

Relevant External Links for RTKN2 Gene

GeneLoc Exon Structure for
RTKN2
ECgene alternative splicing isoforms for
RTKN2

Expression for RTKN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RTKN2 Gene

mRNA differential expression in normal tissues according to GTEx for RTKN2 Gene

This gene is overexpressed in Lung (x19.3), Esophagus - Mucosa (x6.9), and Testis (x4.1).

Protein differential expression in normal tissues from HIPED for RTKN2 Gene

This gene is overexpressed in Esophagus (34.0) and Fetal Brain (33.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RTKN2 Gene



Protein tissue co-expression partners for RTKN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RTKN2 Gene:

RTKN2

SOURCE GeneReport for Unigene cluster for RTKN2 Gene:

Hs.58559

mRNA Expression by UniProt/SwissProt for RTKN2 Gene:

Q8IZC4-RTKN2_HUMAN
Tissue specificity: Expressed in lymphocytes, CD4 positive T-cells and bone marrow-derived cells. Also expressed in lung, colon, thymus and brain.

Evidence on tissue expression from TISSUES for RTKN2 Gene

  • Lung(4.4)
genes like me logo Genes that share expression patterns with RTKN2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTKN2 Gene

Orthologs for RTKN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RTKN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RTKN2 34 35
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia RTKN2 34 35
  • 90.18 (n)
cow
(Bos Taurus)
Mammalia RTKN2 34 35
  • 88.85 (n)
mouse
(Mus musculus)
Mammalia Rtkn2 34 16 35
  • 77.44 (n)
rat
(Rattus norvegicus)
Mammalia Rtkn2 34
  • 75.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RTKN2 35
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RTKN2 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves RTKN2 34 35
  • 73.12 (n)
lizard
(Anolis carolinensis)
Reptilia RTKN2 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rtkn2 34
  • 66.33 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32514 34
zebrafish
(Danio rerio)
Actinopterygii rtkn2a 34 35
  • 58.89 (n)
wufl63a03 34
worm
(Caenorhabditis elegans)
Secernentea C07B5.4 35
  • 20 (a)
OneToMany
Species where no ortholog for RTKN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RTKN2 Gene

ENSEMBL:
Gene Tree for RTKN2 (if available)
TreeFam:
Gene Tree for RTKN2 (if available)

Paralogs for RTKN2 Gene

Paralogs for RTKN2 Gene

(1) SIMAP similar genes for RTKN2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RTKN2: view

Variants for RTKN2 Gene

Sequence variations from dbSNP and Humsavar for RTKN2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000016760 -- 62,236,387(+) TAAAA(C/T)CACTA intron-variant
rs1000017327 -- 62,210,313(+) TTACA(A/G)GTAAA intron-variant
rs1000022942 -- 62,262,883(+) CATAA(C/T)AGATC intron-variant
rs1000029025 -- 62,200,627(+) GGAGT(A/G)AGGTT intron-variant
rs1000040870 -- 62,171,968(+) GGGCC(A/G)TGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RTKN2 Gene

Variant ID Type Subtype PubMed ID
dgv1201n54 CNV loss 21841781
esv2737540 CNV deletion 23290073
esv2737551 CNV deletion 23290073
esv34099 CNV loss 18971310
nsv467292 CNV loss 19166990
nsv551179 CNV loss 21841781
nsv6831 CNV insertion 18451855
nsv831890 CNV gain 17160897
nsv8681 CNV gain 18304495

Variation tolerance for RTKN2 Gene

Residual Variation Intolerance Score: 41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.14; 87.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RTKN2 Gene

Human Gene Mutation Database (HGMD)
RTKN2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RTKN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTKN2 Gene

Disorders for RTKN2 Gene

Relevant External Links for RTKN2

Genetic Association Database (GAD)
RTKN2
Human Genome Epidemiology (HuGE) Navigator
RTKN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RTKN2

No disorders were found for RTKN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RTKN2 Gene

Publications for RTKN2 Gene

  1. Identification and characterization of a lymphocytic Rho-GTPase effector: rhotekin-2. (PMID: 15504364) Collier F.M. … Kirkland M.A. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 22 64
  2. Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C. … Munroe P.B. (Nat. Genet. 2009) 3 46 64
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells. (PMID: 15120425) Gregorio-King C.C. … Kirkland M.A. (J. Steroid Biochem. Mol. Biol. 2004) 3 4 64

Products for RTKN2 Gene

Sources for RTKN2 Gene

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