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Aliases for RTKN2 Gene

Aliases for RTKN2 Gene

  • Rhotekin 2 2 3
  • Pleckstrin Homology Domain Containing, Family K Member 1 2 3
  • Pleckstrin Homology Domain-Containing Family K Member 1 3 4
  • PH Domain-Containing Family K Member 1 3 4
  • PLEKHK1 3 4
  • BA531F24.1 3
  • Rhotekin-2 3

External Ids for RTKN2 Gene

Previous HGNC Symbols for RTKN2 Gene


Previous GeneCards Identifiers for RTKN2 Gene

  • GC10M063035
  • GC10M063835
  • GC10M063613
  • GC10M063942
  • GC10M057942

Summaries for RTKN2 Gene

GeneCards Summary for RTKN2 Gene

RTKN2 (Rhotekin 2) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is RTKN.

UniProtKB/Swiss-Prot for RTKN2 Gene

  • May play an important role in lymphopoiesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTKN2 Gene

Genomics for RTKN2 Gene

Regulatory Elements for RTKN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RTKN2 Gene

62,183,035 bp from pter
62,268,863 bp from pter
85,829 bases
Minus strand

Genomic View for RTKN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RTKN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTKN2 Gene

Proteins for RTKN2 Gene

  • Protein details for RTKN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q3ZCR1
    • Q68DZ6
    • Q8N8K1
    • Q8TAV2

    Protein attributes for RTKN2 Gene

    609 amino acids
    Molecular mass:
    69304 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04837.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BC048002; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for RTKN2 Gene


neXtProt entry for RTKN2 Gene

Proteomics data for RTKN2 Gene at MOPED

Post-translational modifications for RTKN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RTKN2 Gene

Antibody Products

No data available for DME Specific Peptides for RTKN2 Gene

Domains for RTKN2 Gene

Gene Families for RTKN2 Gene

  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for RTKN2 Gene

Suggested Antigen Peptide Sequences for RTKN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8IZC4
  • Contains 1 PH domain.
genes like me logo Genes that share domains with RTKN2: view

Function for RTKN2 Gene

Molecular function for RTKN2 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in lymphopoiesis.
UniProtKB/Swiss-Prot Induction:
Up-regulated in cells resistant to 25-hydroxy cholesterol (25-OHC). Down-regulated in lymphocytes activated by treatment with phytohemagglutinin (PHA).

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RTKN2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RTKN2 Gene

Localization for RTKN2 Gene

Subcellular locations from

Jensen Localization Image for RTKN2 Gene COMPARTMENTS Subcellular localization image for RTKN2 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for RTKN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with RTKN2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RTKN2 Gene

Pathways for RTKN2 Gene

SuperPathways for RTKN2 Gene

No Data Available

Interacting Proteins for RTKN2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8IZC4-RTKN2_HUMAN ENSP00000362894 for RTKN2 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for RTKN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0030097 hemopoiesis IEA --
genes like me logo Genes that share ontologies with RTKN2: view

No data available for Pathways by source for RTKN2 Gene

Transcripts for RTKN2 Gene

Unigene Clusters for RTKN2 Gene

Rhotekin 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RTKN2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTKN2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - - - -
SP2: -
SP4: -

Relevant External Links for RTKN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RTKN2 Gene

mRNA expression in normal human tissues for RTKN2 Gene

mRNA differential expression in normal tissues according to GTEx for RTKN2 Gene

This gene is overexpressed in Lung (19.3), Esophagus - Mucosa (6.9), and Testis (4.1).

Protein differential expression in normal tissues for RTKN2 Gene

This gene is overexpressed in Esophagus (34.0) and Fetal Brain (33.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RTKN2 Gene

SOURCE GeneReport for Unigene cluster for RTKN2 Gene Hs.58559

mRNA Expression by UniProt/SwissProt for RTKN2 Gene

Tissue specificity: Expressed in lymphocytes, CD4 positive T-cells and bone marrow-derived cells. Also expressed in lung, colon, thymus and brain.
genes like me logo Genes that share expressions with RTKN2: view

Expression partners for RTKN2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RTKN2 Gene

Orthologs for RTKN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RTKN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RTKN2 35
  • 88.85 (n)
  • 83.61 (a)
RTKN2 36
  • 83 (a)
(Canis familiaris)
Mammalia RTKN2 35
  • 90.18 (n)
  • 88.08 (a)
RTKN2 36
  • 88 (a)
(Mus musculus)
Mammalia Rtkn2 35
  • 77.44 (n)
  • 74.17 (a)
Rtkn2 16
Rtkn2 36
  • 72 (a)
(Pan troglodytes)
Mammalia RTKN2 35
  • 99.73 (n)
  • 99.59 (a)
RTKN2 36
  • 93 (a)
(Rattus norvegicus)
Mammalia Rtkn2 35
  • 75.23 (n)
  • 66.67 (a)
(Monodelphis domestica)
Mammalia RTKN2 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia RTKN2 36
  • 73 (a)
(Gallus gallus)
Aves RTKN2 35
  • 73.12 (n)
  • 68.32 (a)
RTKN2 36
  • 64 (a)
(Anolis carolinensis)
Reptilia RTKN2 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rtkn2 35
  • 66.33 (n)
  • 60.68 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32514 35
(Danio rerio)
Actinopterygii rtkn2a 35
  • 58.89 (n)
  • 51.22 (a)
wufl63a03 35
rtkn2a 36
  • 45 (a)
(Caenorhabditis elegans)
Secernentea C07B5.4 36
  • 20 (a)
Species with no ortholog for RTKN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RTKN2 Gene

Gene Tree for RTKN2 (if available)
Gene Tree for RTKN2 (if available)

Paralogs for RTKN2 Gene

Paralogs for RTKN2 Gene

Selected SIMAP similar genes for RTKN2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RTKN2: view

Variants for RTKN2 Gene

Sequence variations from dbSNP and Humsavar for RTKN2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs769287 -- 62,246,858(-) TATTC(C/G)AACTT intron-variant
rs958754 -- 62,198,794(-) AATCT(A/G)TAGAA intron-variant
rs1007976 -- 62,210,385(+) ACACA(C/T)GGGTT intron-variant
rs1124197 -- 62,212,646(+) tgcag(G/T)gagct intron-variant
rs1135436 -- 62,196,473(+) TTACA(A/T)CATTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RTKN2 Gene

Variant ID Type Subtype PubMed ID
nsv8681 CNV Gain 18304495
esv34099 CNV Loss 18971310
nsv831890 CNV Gain 17160897
nsv6831 CNV Insertion 18451855
nsv467292 CNV Loss 19166990
esv2737540 CNV Deletion 23290073
esv2737551 CNV Deletion 23290073

Relevant External Links for RTKN2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTKN2 Gene

Disorders for RTKN2 Gene

Relevant External Links for RTKN2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for RTKN2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RTKN2 Gene

Publications for RTKN2 Gene

  1. Identification and characterization of a lymphocytic Rho-GTPase effector: rhotekin-2. (PMID: 15504364) Collier F.M. … Kirkland M.A. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells. (PMID: 15120425) Gregorio-King C.C. … Kirkland M.A. (J. Steroid Biochem. Mol. Biol. 2004) 3 4
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  5. Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C. … Munroe P.B. (Nat. Genet. 2009) 3 48

Products for RTKN2 Gene

Sources for RTKN2 Gene

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