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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RTKN Gene

protein-coding GIFtS: 56
GCID: GC02M074653

rhotekin

Explore 14 diseases affiliated with
RTKN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Rhotekin¹
B5¹
RTKN1³

External Ids:	HGNC: 10466¹	Entrez Gene: 6242²	Ensembl: ENSG00000114993⁷	OMIM: 602288⁵	UniProtKB: Q9BST9³

Export aliases for RTKN gene to outside databases

Previous GC identifers: GC02M074790 GC02M074865 GC02M074610 GC02M074627 GC02M074564 GC02M074506 GC02M074389

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RTKN:

This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the

GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the

inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis,

transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction

pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants

encoding different isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RTKN_HUMAN, Q9BST9

Function: Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in

gastric tumorigenesis. May play a novel role in the organization of septin structures

Gene Wiki entry for RTKN

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RTKN gene promoter:
GR Pax-5 p53 GR-alpha Cdc5
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RTKN promoter sequence

Search SABiosciences Chromatin IP Primers for RTKN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RTKN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.1 Ensembl cytogenetic band: 2p13.1 HGNC cytogenetic band: 2p13.1

RTKN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTKN gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M074653: view genomic region (about GC identifiers)

Start:	74,652,963 bp from pter	End:	74,669,549 bp from pter
Size:	16,587 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RTKN_HUMAN, Q9BST9 (See protein sequence)

Recommended Name: Rhotekin

Size: 563 amino acids; 62667 Da

Subunit: Interacts via its C-terminal region with the TAX1BP3 PDZ domain. This interaction facilitates Rho-mediated

activation of the c-Fos serum response element (SRE). Interacts with SEPT9. Specifically binds to GTP-bound RHOA, RHOB

and RHOC and inhibits their GTPase activity

Sequence caution: Sequence=AAL16767.1; Type=Frameshift; Positions=15, 20;

Secondary accessions: Q8WVN1 Q96PT6 Q9HB05

Alternative splicing: 3 isoforms: Q9BST9-1 Q9BST9-2 Q9BST9-3 (Incomplete sequence)

Explore the universe of human proteins at neXtProt for RTKN: NX_Q9BST9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BST9

RTKN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001015055.1 NP_001015056.1 NP_149035.1

ENSEMBL proteins:

ENSP00000305298 ENSP00000272430 ENSP00000233330

Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant RTKN Protein
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	GenScript Custom Purified and Recombinant Proteins Services for RTKN
	Novus Biologicals RTKN Protein Novus Biologicals RTKN Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RTKN

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005622	intracellular	IEA	--

RTKN for ontologies About GeneDecksing

RTKN Antibody Products:

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	Uscn Antibodies for RTKN
	Search ThermoFisher Antibodies for RTKN

Assay Products for RTKN:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RTKN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RTKN for domains About GeneDecksing

4 InterPro domains/families:

IPR011072 HR1_rho-bd

IPR001849 Pleckstrin_homology

IPR011993 PH_like_dom

IPR012966 DUF1709

Graphical View of Domain Structure for InterPro Entry Q9BST9

ProtoNet protein and cluster: Q9BST9

2 Blocks protein families:

IPB001849 Pleckstrin-like

IPB011072 Protein kinase PKN/PRK1

UniProtKB/Swiss-Prot: RTKN_HUMAN, Q9BST9

Similarity: Contains 1 PH domain

Similarity: Contains 1 REM (Hr1) repeat

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RTKN_HUMAN, Q9BST9

Function: Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in

gastric tumorigenesis. May play a novel role in the organization of septin structures

Genatlas biochemistry entry for RTKN:

rhotekin,61kDa,expressed in many tissues including brain,muscle,binding GTP bound form of Rho inhibiting its GTPase

activity

miRNA Products:		OriGene 3'-UTR Clone (see all 3): RTKN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RTKN
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate RTKN (see all 24):
		hsa-miR-1321 hsa-let-7d hsa-miR-4328 hsa-miR-301a hsa-let-7c hsa-miR-520a-5p hsa-miR-3916 hsa-miR-3125

		SwitchGear 3'UTR luciferase reporter plasmid: RTKN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RTKN (see all 7) OriGene shRNA RFP: RTKN OriGene siRNA: RTKN
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RTKN

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		GenScript: all cDNA clones in your preferred vector (see all 3): RTKN (NM_001015055)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTKN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RTKN
		Search LifeMap BioReagents cell lines for RTKN

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTKN

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005095	GTPase inhibitor activity	IDA	10940294
GO:0005515	protein binding	IPI	16007136
GO:0005525	GTP binding	IEA	--
GO:0005543	phospholipid binding	IEA	--
GO:0017048	Rho GTPase binding	--	--

RTKN for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G-protein signaling_RhoA regulation pathway

G-protein signaling RhoB regulation pathway

0.16

G-protein signaling_RhoB regulation pathway

0.16

Alpha6-Beta4 Integrin Signaling Pathway

Alpha6-Beta4 Integrin Signaling Pathway

1.00

G13 Signaling Pathway

G13 Signaling Pathway

1.00

Actin Nucleation by ARP-WASP Complex

RhoA Pathway

0.35

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for RTKN

G-protein signaling RhoB regulation pathway

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RTKN

RhoA Pathway

1 GeneGo (Thomson Reuters) Pathway for RTKN

G-protein signaling RhoB regulation pathway

2 BioSystems Pathways for RTKN

	G13 Signaling Pathway
	Alpha6-Beta4 Integrin Signaling Pathway

RTKN for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RTKN

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/19 Interacting proteins for RTKN (Q9BST9^{2, 3} ENSP00000272430⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SORBS3	O60504²^,³, ENSP00000240123⁴	MINT-7215715 MINT-7215651 MINT-7215594 MINT-7215608 MINT-7215695 MINT-7215670 I2D: score=1 STRING: ENSP00000240123
RHOA	P61586²^,³, ENSP00000400175⁴	MINT-6504377 MINT-7301170 MINT-7146266 MINT-8378406 MINT-8380722 I2D: score=8 STRING: ENSP00000400175
RAC1	P63000²^,³, ENSP00000348461⁴	MINT-6504419 I2D: score=1 STRING: ENSP00000348461
SMURF1	Q9HCE7³, ENSP00000354621⁴	I2D: score=2 STRING: ENSP00000354621
TAX1BP3	O14907³, ENSP00000225525⁴	I2D: score=2 STRING: ENSP00000225525

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	IEA	--
GO:0007165	signal transduction	IDA	10940294
GO:0007266	Rho protein signal transduction	IDA	15480428
GO:0045767	regulation of anti-apoptosis	--	--

RTKN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RTKN for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RTKN

1 HMDB Compound for RTKN About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

2 Novoseek chemical compound relationships for RTKN gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
butyrate	38.6	4	15480428 (1)
serine	5.98	1	10940294 (1)

Search CenterWatch for drugs/clinical trials and news about RTKN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RTKN gene (3 alternative transcripts):

NM_001015055.1 NM_001015056.1 NM_033046.2

Unigene Cluster for RTKN:

Rhotekin

Hs.192854 [show with all ESTs]

Unigene Representative Sequence: NM_033046

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000305557(uc002slc.3 uc002sld.3) ENST00000272430(uc002sle.3)

ENST00000233330 ENST00000492013 ENST00000469859 ENST00000479256 ENST00000472518(uc010ffe.1 uc010ffg.1)

ENST00000464094(uc010fff.1) ENST00000460968 ENST00000484453

miRNA Products:		OriGene 3'-UTR Clone (see all 3): RTKN Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RTKN
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate RTKN (see all 24):
		hsa-miR-1321 hsa-let-7d hsa-miR-4328 hsa-miR-301a hsa-let-7c hsa-miR-520a-5p hsa-miR-3916 hsa-miR-3125

		SwitchGear 3'UTR luciferase reporter plasmid: RTKN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RTKN (see all 7) OriGene shRNA RFP: RTKN OriGene siRNA: RTKN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RTKN

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RTKN (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RTKN (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): RTKN (NM_001015055)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RTKN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTKN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RTKN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RTKN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RTKN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTKN

Additional cDNA sequence:

AF049227.1 AF290512.1 AK307302.1 AK308519.1 AK310036.1 BC004558.2 BC017727.1

13 DOTS entries:

DT.444757 DT.308997 DT.100813635 DT.95323126 DT.100813632 DT.100813631 DT.120962463 DT.91816878

DT.100813627 DT.102825351 DT.92027421 DT.95323124 DT.75114775

24/236 AceView cDNA sequences (see all 236):

BG818751 BF594629 BF594415 BG576489 BM544606 BE073469 BU165989 AA366268

BQ576156 AI880313 AA401843 BQ006183 AI936859 BU552468 BM799779 BC017727

AI061102 AW410754 BM921551 AA341645 BI752701 NM_033046 CA848925 AI202716

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RTKN (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	^	14	^	15a	·
SP1:							-		-		-		-								-		-		-																				-
SP2:																					-		-		-																				-
SP3:											-		-								-		-		-
SP4:																					-		-		-		-
SP5:																																									-				-

ExUns:	15b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for RTKN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RTKN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTACCGAGGG

About this image

RTKN expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RTKN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RTKN

SOURCE GeneReport for Unigene cluster: Hs.192854

UniProtKB/Swiss-Prot: RTKN_HUMAN, Q9BST9

Tissue specificity: Highly expressed in prostate, moderately in kidney, heart, brain, spleen, testis, placenta, small

intestine, pancreas, skeletal muscle and peripheral blood leukocytes, and weakly in ovary, colon and thymus. Weakly

expressed in all normal cell lines tested. Overexpressed in various cancer cell lines

SABiosciences Custom PCR Arrays for RTKN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RTKN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RTKN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RTKN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTKN

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTKN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RTKN gene from 5/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	RTKN⁶	--	56(a)	1 ↔ 1	GL344233.1(39717-52283)
African clawed frog (Xenopus laevis)	Amphibia	BJ043112.1²	--	75.4(n)		BJ043112.1
zebrafish (Danio rerio)	Actinopterygii	BM571991.1²	--	73.33(n)		BM571991.1
honey bee (Apis mellifera)	Insecta	--	--	29(a)	1 → many	Group15.3(312878-315094)
worm (Caenorhabditis elegans)	Secernentea	C07B5.4⁶	Protein C07B5.4, isoform a	18(a)	1 → many	X(9529476-9536577)

ENSEMBL Gene Tree for RTKN (if available)
TreeFam Gene Tree for RTKN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RTKN gene

RTKN2²

1 SIMAP similar gene for RTKN using alignment to 2 protein entries: RTKN_HUMAN (see all proteins):

RTKN2

RTKN for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs56403792^1,2	C,	--	74652505(+)	`TGTCCG/CGTCAG`	4	--	ds500¹ int¹		1		WA	2
rs13383283^1,2	C	--	74652629(+)	`TGTCAT/GGGGGT`	4	--	int¹ ds500¹		1		NA	2
rs200063277^1,2		--	74652644(+)	`GGAATG/TGGGGG`	4	--	int¹ ds500¹		0	--	--	--	--
rs201672730^1,2		--	74652656(+)	`CCCAAA/GCATGG`	4	--	int¹ ds500¹		0	--	--	--	--
rs199822193^1,2	C,F,	--	74652856(+)	`CTGTGG/CTATTC`	4	--	ut3¹ ds500¹		1		EU	1251
rs137868786^1,2		--	74652936(+)	`ACTATG/TCTCCA`	4	--	ds500¹ int¹		0	--	--	--	--
rs80280553^1,2	C,F,	--	74653043(+)	`TGGGAG/ATCACA`	4	--	int¹ ut3¹		1		WA	118
rs4387825^1,2	C	--	74653057(+)	`GAGGTA/GTGTTT`	4	--	ut3¹ int¹ ese³		1		NA	2
rs116324821^1,2	F,	--	74653265(+)	`AACAGG/AAGGCC`	4	--	int¹ ut3¹		1		WA	118
rs116441707^1,2	C,F,	--	74653291(+)	`CTATAG/AACAGC`	4	--	ut3¹ int¹		1		NA	120

HapMap Linkage Disequilibrium report for RTKN (74652963 - 74669549 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for RTKN
4 CNVs: 50556 3366 50557 50558

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RTKN

DNA2.0 Custom Variant and Variant Library Synthesis for RTKN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RTKN for disorders           About GeneDecksing

OMIM gene information: 602288    OMIM disorders: --

14 diseases for RTKN:    About MalaCards

hereditary neuralgic amyotrophy amyotrophic neuralgia bladder carcinoma gastric adenocarcinoma

alzheimer's disease pancreatic cancer adenocarcinoma prostate cancer

breast cancer pancreatitis prostatitis carcinoma

leukemia neuronitis

2 Novoseek disease relationships for RTKN gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gastric cancer	16.9	3	15480428 (1)
metastasis	9.84	2	15316142 (1)

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RTKN gene, integrated from 9 sources (see all 53):
(articles sorted by number of sources associating them with RTKN)

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The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element. (PubMed id 10940294)^{1, 2, 3, 9} Reynaud C.... Jalinot P. (2000)
Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis. (PubMed id 15480428)^{1, 2, 9} Liu C.-A.... Chen J.-Y. (2004)
Molecular cloning, expression characterization, and mapping of a novel putative inhibitor of rho GTPase activity, RTKN, to D2S145- D2S286. (PubMed id 10873388)^{1, 2, 9} Fu Q.... Zhao S. (2000)
Possible role of Rho/Rhotekin signaling in mammalian septin organization. (PubMed id 16007136)^{1, 2} Ito H....Nagata K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Localization of the rhotekin gene RTKN on the physical maps of mouse chromosome 6 and human chromosome 2p13 and exclusion as a candidate for mnd2 and LGMD2B. (PubMed id 9073523)^{1, 3} Jang W....Meisler M.H. (1997)
Overexpression of rho effector rhotekin confers increased survival in gastric adenocarcinoma. (PubMed id 15316142)^{1, 9} Liu C.A....Chen J.Y. (2004)
Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons. (PubMed id 16979770)^{1, 9} Sudo K.... Nagata K. (2006)
Interaction of a multi-domain adaptor protein, vinexin, with a Rho-effector, Rhotekin. (PubMed id 19294487)^{1, 9} Nagata K....Asano T. (2009)
Protein kinase D regulates RhoA activity via rhotekin phosphorylation. (PubMed id 22228765)¹ Pusapati G.V....Seufferlein T. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6242	HGNC: 10466	AceView: RTKN	Ensembl:ENSG00000114993	euGenes: HUgn6242
ECgene: RTKN	H-InvDB: RTKN

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RTKN	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RTKN gene
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Patent Information for RTKN gene:
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