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RTKN Gene

protein-coding   GIFtS: 59
GCID: GC02M074667

Rhotekin

  See RTKN-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
rhotekin1 2
RTKN13

External Ids:    HGNC: 104661   Entrez Gene: 62422   Ensembl: ENSG000001149937   OMIM: 6022885   UniProtKB: Q9BST93   

Export aliases for RTKN gene to outside databases

Previous GC identifers: GC02M074790 GC02M074865 GC02M074610 GC02M074627 GC02M074564 GC02M074506 GC02M074653 GC02M074389 GC02M074660


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RTKN Gene:
This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits
the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to
the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including
cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho
signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple
transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for RTKN Gene:
RTKN (rhotekin) is a protein-coding gene. Diseases associated with RTKN include hereditary neuralgic amyotrophy. GO annotations related to this gene include GTP binding and GTPase inhibitor activity. An important paralog of this gene is RTKN2.

UniProtKB/Swiss-Prot: RTKN_HUMAN, Q9BST9
Function: Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells
in gastric tumorigenesis. May play a novel role in the organization of septin structures

Gene Wiki entry for RTKN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RTKN gene promoter:
         GR   Pax-5   p53   GR-alpha   Cdc5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RTKN promoter sequence
   Search Chromatin IP Primers for RTKN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RTKN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.1   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p13.1

RTKN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTKN gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M074667:  view genomic region     (about GC identifiers)

Start:
74,652,963 bp from pter      End:
74,669,549 bp from pter
Size:
16,587 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RTKN_HUMAN, Q9BST9 (See protein sequence)
Recommended Name: Rhotekin  
Size: 563 amino acids; 62667 Da
Subunit: Interacts via its C-terminal region with the TAX1BP3 PDZ domain. This interaction facilitates
Rho-mediated activation of the c-Fos serum response element (SRE). Interacts with SEPT9. Specifically binds to
GTP-bound RHOA, RHOB and RHOC and inhibits their GTPase activity
Sequence caution: Sequence=AAL16767.1; Type=Frameshift; Positions=15, 20;
Secondary accessions: H7BXD4 Q8WVN1 Q96PT6 Q9HB05
Alternative splicing: 3 isoforms:  Q9BST9-1   Q9BST9-2   Q9BST9-3   (Incomplete sequence)

Explore the universe of human proteins at neXtProt for RTKN: NX_Q9BST9

Explore proteomics data for RTKN at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RTKN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001015055.1  NP_001015056.1  NP_149035.1  

    ENSEMBL proteins: 
     ENSP00000305298   ENSP00000272430   ENSP00000233330  

    RTKN Human Recombinant Protein Products:

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    Novus Biologicals RTKN Protein
    Novus Biologicals RTKN Lysate
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    Cloud-Clone Corp. Proteins for RTKN

     
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    Search eBioscience for ELISAs for RTKN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    4 InterPro protein domains:
     IPR011072 HR1_rho-bd
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR012966 DUF1709

    Graphical View of Domain Structure for InterPro Entry Q9BST9

    ProtoNet protein and cluster: Q9BST9

    2 Blocks protein domains:
    IPB001849 Pleckstrin-like
    IPB011072 Protein kinase PKN/PRK1


    UniProtKB/Swiss-Prot: RTKN_HUMAN, Q9BST9
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 REM (Hr1) repeat


    Find genes that share domains with RTKN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RTKN_HUMAN, Q9BST9
    Function: Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells
    in gastric tumorigenesis. May play a novel role in the organization of septin structures

         Genatlas biochemistry entry for RTKN:
    rhotekin,61kDa,expressed in many tissues including brain,muscle,binding GTP bound form of Rho inhibiting its
    GTPase activity

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005095GTPase inhibitor activity IDA10940294
    GO:0005515protein binding IPI10940294
    GO:0005525GTP binding IEA--
    GO:0017048Rho GTPase binding ----
    GO:0017049GTP-Rho binding IDA10940294
         
    Find genes that share ontologies with RTKN           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RTKN
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RTKN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RTKN

    miRNA
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    miRTarBase miRNAs that target RTKN:
    hsa-mir-1296-5p (MIRT036125), hsa-mir-145-5p (MIRT021499), hsa-mir-320b (MIRT036220)

    Block miRNA regulation of human, mouse, rat RTKN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RTKN (see all 24):
    hsa-miR-1321 hsa-let-7d hsa-miR-4328 hsa-miR-301a hsa-let-7c hsa-miR-520a-5p hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidRTKN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RTKN

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): RTKN (NM_001015055)
    Sino Biological Human cDNA Clone for RTKN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RTKN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTKN

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTKN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton2
    cytosol2
    mitochondrion2
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    Find genes that share ontologies with RTKN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RTKN About    
    See pathways by source

    SuperPathContained pathways About
    1Actin Nucleation by ARP-WASP Complex
    RhoA Pathway0.35
    2G protein signaling RhoB regulation pathway
    G protein signaling RhoB regulation pathway
    3G13 Signaling Pathway
    G13 Signaling Pathway
    4Alpha6-Beta4 Integrin Signaling Pathway
    Alpha6-Beta4 Integrin Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RTKN
        RhoA Pathway

    1 GeneGo (Thomson Reuters) Pathway for RTKN
        G-protein signaling RhoB regulation pathway

    2 BioSystems Pathways for RTKN
        G13 Signaling Pathway
    Alpha6-Beta4 Integrin Signaling Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RTKN
    Interactions:

        GeneGlobe Interaction Network for RTKN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for RTKN (Q9BST91, 2, 3 ENSP000002724304) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SORBS3O605041, 2, 3, ENSP000002401234EBI-446694,EBI-741237 MINT-7215715 MINT-7215651 MINT-7215594 MINT-7215608 MINT-7215695 MINT-7215670 I2D: score=1 STRING: ENSP00000240123
    RHOAP615861, 2, 3, ENSP000004001754EBI-446694,EBI-446668 MINT-6504377 MINT-7301170 MINT-7146266 MINT-8378406 MINT-8380722 I2D: score=8 STRING: ENSP00000400175
    RAC1P630002, 3, ENSP000003484614MINT-6504419 I2D: score=1 STRING: ENSP00000348461
    SMURF1Q9HCE73, ENSP000003546214I2D: score=2 STRING: ENSP00000354621
    TAX1BP3O149073, ENSP000002255254I2D: score=2 STRING: ENSP00000225525
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction IDA10940294
    GO:0007266Rho protein signal transduction IDA15480428
    GO:0043086negative regulation of catalytic activity IDA10940294

    Find genes that share ontologies with RTKN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RTKN

    1 HMDB Compound for RTKN    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 Novoseek inferred chemical compound relationships for RTKN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    butyrate 38.6 4 15480428 (1)
    serine 5.98 1 10940294 (1)



    Find genes that share compounds with RTKN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RTKN gene (3 alternative transcripts): 
    NM_001015055.1  NM_001015056.1  NM_033046.2  

    Unigene Cluster for RTKN:

    Rhotekin
    Hs.192854  [show with all ESTs]
    Unigene Representative Sequence: NM_033046
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305557(uc002slc.3 uc002sld.3) ENST00000272430(uc002sle.3)
    ENST00000233330 ENST00000492013 ENST00000469859 ENST00000479256 ENST00000472518(uc010ffe.1 uc010ffg.1)
    ENST00000464094(uc010fff.1) ENST00000460968 ENST00000484453
    miRNA
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    Block miRNA regulation of human, mouse, rat RTKN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RTKN (see all 24):
    hsa-miR-1321 hsa-let-7d hsa-miR-4328 hsa-miR-301a hsa-let-7c hsa-miR-520a-5p hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidRTKN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RTKN
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    GenScript: all cDNA clones in your preferred vector (see all 3): RTKN (NM_001015055)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RTKN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTKN
    Primer
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    OriGene qPCR primer pairs and template standards for RTKN
    OriGene qSTAR qPCR primer pairs in human, mouse for RTKN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RTKN
      QuantiTect SYBR Green Assays in human, mouse, rat RTKN
      QuantiFast Probe-based Assays in human, mouse, rat RTKN

    Additional mRNA sequence: 

    AF049227.1 AF290512.1 AK307302.1 AK308519.1 AK310036.1 BC004558.2 BC017727.1 

    13 DOTS entries:

    DT.444757  DT.308997  DT.100813635  DT.95323126  DT.100813632  DT.100813631  DT.120962463  DT.91816878 
    DT.100813627  DT.102825351  DT.92027421  DT.95323124  DT.75114775 

    Selected AceView cDNA sequences (see all 236):

    BQ721791 BM799779 BM795548 BQ936904 AI651576 BM272585 BU542771 Z40631 
    AI202716 CR599244 AA366268 BM544606 BU165989 BI752701 AI936859 BF594629 
    BM555731 BI554239 BC017727 AA401843 BI712161 BM666431 BG576489 BQ574374 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RTKN (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a ·
    SP1:                    -     -     -     -                       -     -     -                                                           -                     
    SP2:                                                              -     -     -                                                           -                     
    SP3:                                -     -                       -     -     -                                                                                 
    SP4:                                                              -     -     -     -                                                                           
    SP5:                                                                                                                          -           -                     

    ExUns: 15b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for RTKN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RTKN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACCGAGGG
    RTKN Expression
    About this image


    RTKN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Kidney (Urinary System)
    RTKN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RTKN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.192854

    UniProtKB/Swiss-Prot: RTKN_HUMAN, Q9BST9
    Tissue specificity: Highly expressed in prostate, moderately in kidney, heart, brain, spleen, testis, placenta,
    small intestine, pancreas, skeletal muscle and peripheral blood leukocytes, and weakly in ovary, colon and
    thymus. Weakly expressed in all normal cell lines tested. Overexpressed in various cancer cell lines

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    QuantiFast Probe-based Assays in human, mouse, rat RTKN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTKN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RTKN gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rtkn1 , 5 rhotekin1, 5 87.21(n)1
    86.86(a)1
      6 (35.94 cM)5
    201661  NM_001136227.11  NP_001129699.11 
     831354635 
    lizard
    (Anolis carolinensis)
    Reptilia RTKN6
    rhotekin
    57(a)
    1 ↔ 1
    GL344233.1(39717-53822)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ043112.12   -- 75.4(n)    BJ043112.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM571991.12   -- 73.33(n)    BM571991.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C07B5.46
    Protein C07B5.4, isoform a
    18(a)
    1 → many
    X(9529533-9536634) WBGene00007409


    ENSEMBL Gene Tree for RTKN (if available)
    TreeFam Gene Tree for RTKN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RTKN gene
    RTKN22  
    1 SIMAP similar gene for RTKN using alignment to 1 protein entry:     RTKN_HUMAN:
    RTKN2

    Find genes that share paralogs with RTKN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RTKN (see all 425)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2013471981,2
    --74653395(+) AAGTGC/TGAGGT 6 H R mis10--------
    rs2000434861,2
    C--74653398(+) TGCGAG/AGTTGG 6 /P /L mis11Minor allele frequency- A:0.00EU 751
    rs767722551,2
    C,F--74653400(+) CGAGGT/CTGGCC 6 /Q syn12Minor allele frequency- C:0.04WA NA 4106
    rs1428422511,2
    C,F--74653413(+) TGCTGC/TAGAGG 6 Y C mis11Minor allele frequency- T:0.00NA 4038
    rs1423664891,2
    --74653480(+) GGAGTA/GGTCTG 6 H Y mis10--------
    rs2005473331,2
    --74653598(+) GGCTGG/TTCTGT 6 E D mis10--------
    rs1996737041,2
    --74653615(+) TGCCAG/TCCAGG 6 M L mis10--------
    rs1459496531,2
    C,F--74653642(+) CCTTGC/TGCCCT 6 T A mis11Minor allele frequency- T:0.00NA 3640
    rs2016335311,2
    --74653643(+) CTTGCA/GCCCTC 6 G syn10--------
    rs750082081,2
    C,F--74653661(+) GTCAGG/TATGTC 6 I syn12Minor allele frequency- T:0.00NA EU 4595

    HapMap Linkage Disequilibrium report for RTKN (74652963 - 74669549 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RTKN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv458185CNV Loss19166990
    nsv515851CNV Loss19592680
    dgv4166n71CNV Loss21882294
    dgv1199e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602288    OMIM disorders: --

    1 disease for RTKN:    
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    hereditary neuralgic amyotrophy


    Find genes that share disorders with RTKN           About GenesLikeMe

    2 Novoseek inferred disease relationships for RTKN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastric cancer 16.9 3 15480428 (1)
    metastasis 9.84 2 15316142 (1)


    Export disorders for RTKN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RTKN gene, integrated from 10 sources (see all 57):
    (articles sorted by number of sources associating them with RTKN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element. (PubMed id 10940294)1, 2, 3, 9 Reynaud C.... Jalinot P. (J. Biol. Chem. 2000)
    2. Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis. (PubMed id 15480428)1, 2, 9 Liu C.-A.... Chen J.-Y. (Oncogene 2004)
    3. Molecular cloning, expression characterization, and mapping of a novel putative inhibitor of rho GTPase activity, RTKN, to D2S145- D2S286. (PubMed id 10873388)1, 2, 9 Fu Q.... Zhao S. (Genomics 2000)
    4. Possible role of Rho/Rhotekin signaling in mammalian septin organization. (PubMed id 16007136)1, 2 Ito H....Nagata K. (Oncogene 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Localization of the rhotekin gene RTKN on the physical maps of mouse chromosome 6 and human chromosome 2p13 and exclusion as a candidate for mnd2 and LGMD2B. (PubMed id 9073523)1, 3 Jang W....Meisler M.H. (Genomics 1997)
    7. Overexpression of rho effector rhotekin confers increased survival in gastric adenocarcinoma. (PubMed id 15316142)1, 9 Liu C.A....Chen J.Y. (J. Biomed. Sci. 2004)
    8. Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons. (PubMed id 16979770)1, 9 Sudo K.... Nagata K. (Neurosci. Res. 2006)
    9. Interaction of a multi-domain adaptor protein, vinexin, with a Rho-effector, Rhotekin. (PubMed id 19294487)1, 9 Nagata K....Asano T. (Med Mol Morphol 2009)
    10. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6242 HGNC: 10466 AceView: RTKN Ensembl:ENSG00000114993 euGenes: HUgn6242
    ECgene: RTKN H-InvDB: RTKN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RTKN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RTKN gene:
    Search GeneIP for patents involving RTKN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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