Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RTKN Gene

Aliases for RTKN Gene

  • Rhotekin 2 3 3 5
  • RTKN1 4

External Ids for RTKN Gene

Previous GeneCards Identifiers for RTKN Gene

  • GC02M074790
  • GC02M074865
  • GC02M074610
  • GC02M074627
  • GC02M074564
  • GC02M074506
  • GC02M074653
  • GC02M074389
  • GC02M074660
  • GC02M074667

Summaries for RTKN Gene

Entrez Gene Summary for RTKN Gene

  • This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for RTKN Gene

RTKN (Rhotekin) is a Protein Coding gene. Among its related pathways are Actin Nucleation by ARP-WASP Complex and Signaling by GPCR. GO annotations related to this gene include GTP binding and GTP-Rho binding. An important paralog of this gene is RTKN2.

UniProtKB/Swiss-Prot for RTKN Gene

  • Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures.

Gene Wiki entry for RTKN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTKN Gene

Genomics for RTKN Gene

Regulatory Elements for RTKN Gene

Enhancers for RTKN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F074570 1.5 FANTOM5 Ensembl ENCODE 10.5 -132.4 -132379 8.8 HDGF PKNOX1 ARID4B SIN3A BMI1 RAD21 ZBTB40 RARA CHAMP1 YY1 MOGS DOK1 LBX2-AS1 AUP1 HTRA2 TLX2 PCGF1 CCDC142 TTC31 DQX1
GH02F074566 1.3 FANTOM5 Ensembl ENCODE 10 -125.3 -125257 3.4 ZFP64 EBF1 CBX5 SCRT2 FOS NFE2L2 MTA2 HLF CEBPB ZNF781 SEMA4F LBX2 BOLA3-AS1 WBP1 HTRA2 AUP1 TLX2 PCGF1 MRPL53 MOGS
GH02F074204 1.2 Ensembl ENCODE 9.8 +236.7 236651 2.9 PKNOX1 ATF1 CREB3L1 WRNIP1 FEZF1 ZNF121 NCOA1 JUNB TBX21 ZNF592 BOLA3-AS1 MOB1A BOLA3 RTKN LOC107985899 MTHFD2 GC02P074217
GH02F074266 1.1 Ensembl ENCODE 9.9 +175.1 175118 1.2 ELF3 PKNOX1 ATF1 RAD21 RARA CEBPB GATAD2B REST PPARG KLF16 ENSG00000273245 SLC4A5 C2orf81 WDR54 RTKN KRT18P26 GC02P074217
GH02F074372 1 Ensembl ENCODE 10.6 +68.4 68433 2.5 KLF1 ATF1 ZFHX2 POLR2A ZNF600 CREM EGR2 RFX1 SP3 MAZ SLC4A5 C2orf81 WDR54 RTKN BOLA3 BOLA3-AS1 ENSG00000272183 MOGS GC02M074371 ENSG00000264324
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RTKN on UCSC Golden Path with GeneCards custom track

Promoters for RTKN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000122848 1222 2801 HDGF MLX ZFP64 SIN3A ARID4B DMAP1 ZNF2 YY1 SLC30A9 SP3

Genomic Location for RTKN Gene

Chromosome:
2
Start:
74,425,836 bp from pter
End:
74,442,422 bp from pter
Size:
16,587 bases
Orientation:
Minus strand

Genomic View for RTKN Gene

Genes around RTKN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTKN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTKN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTKN Gene

Proteins for RTKN Gene

  • Protein details for RTKN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BST9-RTKN_HUMAN
    Recommended name:
    Rhotekin
    Protein Accession:
    Q9BST9
    Secondary Accessions:
    • H7BXD4
    • Q8WVN1
    • Q96PT6
    • Q9HB05

    Protein attributes for RTKN Gene

    Size:
    563 amino acids
    Molecular mass:
    62667 Da
    Quaternary structure:
    • Interacts via its C-terminal region with the TAX1BP3 PDZ domain. This interaction facilitates Rho-mediated activation of the c-Fos serum response element (SRE). Interacts with SEPT9. Specifically binds to GTP-bound RHOA, RHOB and RHOC and inhibits their GTPase activity.
    SequenceCaution:
    • Sequence=AAL16767.1; Type=Frameshift; Positions=15, 20; Evidence={ECO:0000305};

    Alternative splice isoforms for RTKN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RTKN Gene

Post-translational modifications for RTKN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RTKN Gene

Domains & Families for RTKN Gene

Gene Families for RTKN Gene

Protein Domains for RTKN Gene

Suggested Antigen Peptide Sequences for RTKN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BST9

UniProtKB/Swiss-Prot:

RTKN_HUMAN :
  • Contains 1 PH domain.
  • Contains 1 REM (Hr1) repeat.
Domain:
  • Contains 1 PH domain.
Similarity:
  • Contains 1 REM (Hr1) repeat.
genes like me logo Genes that share domains with RTKN: view

Function for RTKN Gene

Molecular function for RTKN Gene

GENATLAS Biochemistry:
rhotekin,61kDa,expressed in many tissues including brain,muscle,binding GTP bound form of Rho inhibiting its GTPase activity
UniProtKB/Swiss-Prot Function:
Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures.

Gene Ontology (GO) - Molecular Function for RTKN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005095 GTPase inhibitor activity IDA 10940294
GO:0005515 protein binding IPI 10940294
GO:0005525 GTP binding IEA --
GO:0017048 Rho GTPase binding IEA --
GO:0017049 GTP-Rho binding IDA 10940294
genes like me logo Genes that share ontologies with RTKN: view
genes like me logo Genes that share phenotypes with RTKN: view

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RTKN Gene

Localization for RTKN Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTKN gene
Compartment Confidence
cytosol 5
mitochondrion 3
nucleus 3
cytoskeleton 2
plasma membrane 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RTKN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RTKN: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RTKN Gene

Pathways & Interactions for RTKN Gene

genes like me logo Genes that share pathways with RTKN: view

Pathways by source for RTKN Gene

1 GeneGo (Thomson Reuters) pathway for RTKN Gene
1 Qiagen pathway for RTKN Gene

SIGNOR curated interactions for RTKN Gene

Inactivates:

Gene Ontology (GO) - Biological Process for RTKN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IDA 10940294
GO:0007266 Rho protein signal transduction IDA 15480428
GO:0034260 negative regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RTKN: view

Drugs & Compounds for RTKN Gene

(2) Drugs for RTKN Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for RTKN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RTKN: view

Transcripts for RTKN Gene

Unigene Clusters for RTKN Gene

Rhotekin:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTKN Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a ·
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - -
SP5: - -
SP6: - - -
SP7:
SP8: - - - - -
SP9:
SP10: - - - -

ExUns: 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for RTKN Gene

GeneLoc Exon Structure for
RTKN
ECgene alternative splicing isoforms for
RTKN

Expression for RTKN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RTKN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RTKN Gene

This gene is overexpressed in Liver (x5.7) and Brain - Spinal cord (cervical c-1) (x4.2).

Protein differential expression in normal tissues from HIPED for RTKN Gene

This gene is overexpressed in Plasma (32.0), Pancreas (8.6), Islet of Langerhans (7.3), and Pancreatic juice (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RTKN Gene



NURSA nuclear receptor signaling pathways regulating expression of RTKN Gene:

RTKN

SOURCE GeneReport for Unigene cluster for RTKN Gene:

Hs.192854

mRNA Expression by UniProt/SwissProt for RTKN Gene:

Q9BST9-RTKN_HUMAN
Tissue specificity: Highly expressed in prostate, moderately in kidney, heart, brain, spleen, testis, placenta, small intestine, pancreas, skeletal muscle and peripheral blood leukocytes, and weakly in ovary, colon and thymus. Weakly expressed in all normal cell lines tested. Overexpressed in various cancer cell lines.
genes like me logo Genes that share expression patterns with RTKN: view

No data available for Protein tissue co-expression partners for RTKN Gene

Orthologs for RTKN Gene

This gene was present in the common ancestor of animals.

Orthologs for RTKN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RTKN 34 35
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia RTKN 34 35
  • 92.13 (n)
cow
(Bos Taurus)
Mammalia RTKN 34 35
  • 91 (n)
mouse
(Mus musculus)
Mammalia Rtkn 34 16 35
  • 87.21 (n)
rat
(Rattus norvegicus)
Mammalia Rtkn 34
  • 87.15 (n)
oppossum
(Monodelphis domestica)
Mammalia RTKN 35
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RTKN 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rtkn 34
  • 63.17 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-40c11.1 34
  • 62.06 (n)
rtkn2b 35
  • 51 (a)
OneToMany
RTKN (1 of 2) 35
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C07B5.4 35
  • 18 (a)
OneToMany
Species where no ortholog for RTKN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RTKN Gene

ENSEMBL:
Gene Tree for RTKN (if available)
TreeFam:
Gene Tree for RTKN (if available)

Paralogs for RTKN Gene

Paralogs for RTKN Gene

(1) SIMAP similar genes for RTKN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RTKN: view

Variants for RTKN Gene

Sequence variations from dbSNP and Humsavar for RTKN Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1001123 -- 74,432,696(-) CATTT(A/C)CTTCT intron-variant
rs1003729 -- 74,432,262(-) ACTTA(C/G)AAAAG intron-variant
rs1003730 -- 74,431,328(-) CTGCA(A/G)TGGGG intron-variant
rs1048376 -- 74,425,928(-) ACATA(A/C)CTCCC intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs111522074 -- 74,434,304(+) GAGAC(C/T)GAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RTKN Gene

Variant ID Type Subtype PubMed ID
esv2759061 CNV loss 17122850
nsv458185 CNV loss 19166990
nsv515851 CNV loss 19592680
nsv582214 CNV loss 21841781

Variation tolerance for RTKN Gene

Residual Variation Intolerance Score: 21.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RTKN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RTKN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTKN Gene

Disorders for RTKN Gene

Relevant External Links for RTKN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RTKN

No disorders were found for RTKN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RTKN Gene

Publications for RTKN Gene

  1. The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element. (PMID: 10940294) Reynaud C. … Jalinot P. (J. Biol. Chem. 2000) 2 3 4 22 64
  2. Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis. (PMID: 15480428) Liu C.-A. … Chen J.-Y. (Oncogene 2004) 3 4 22 64
  3. Molecular cloning, expression characterization, and mapping of a novel putative inhibitor of rho GTPase activity, RTKN, to D2S145- D2S286. (PMID: 10873388) Fu Q. … Zhao S. (Genomics 2000) 3 4 22 64
  4. Interaction of a multi-domain adaptor protein, vinexin, with a Rho-effector, Rhotekin. (PMID: 19294487) Nagata K. … Asano T. (Med Mol Morphol 2009) 3 22 64
  5. Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons. (PMID: 16979770) Sudo K. … Nagata K. (Neurosci. Res. 2006) 3 22 64

Products for RTKN Gene

Sources for RTKN Gene

Content
Loading form....