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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RTKN Gene

protein-coding   GIFtS: 59
GCID: GC02M074660

Rhotekin

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
rhotekin1 2
RTKN13

External Ids:    HGNC: 104661   Entrez Gene: 62422   Ensembl: ENSG000001149937   OMIM: 6022885   UniProtKB: Q9BST93   

Export aliases for RTKN gene to outside databases

Previous GC identifers: GC02M074790 GC02M074865 GC02M074610 GC02M074627 GC02M074564 GC02M074506 GC02M074653 GC02M074389


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RTKN Gene:
This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits
the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to
the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including
cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho
signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple
transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for RTKN Gene: 
RTKN (rhotekin) is a protein-coding gene. Diseases associated with RTKN include amyotrophic neuralgia, and hereditary neuralgic amyotrophy, and among its related super-pathways are G-protein signaling RhoB regulation pathway and Actin Nucleation by ARP-WASP Complex. GO annotations related to this gene include GTP binding and GTPase inhibitor activity. An important paralog of this gene is RTKN2.

UniProtKB/Swiss-Prot: RTKN_HUMAN, Q9BST9
Function: Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells
in gastric tumorigenesis. May play a novel role in the organization of septin structures

Gene Wiki entry for RTKN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RTKN gene promoter:
         GR   Pax-5   p53   GR-alpha   Cdc5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RTKN promoter sequence
   Search SABiosciences Chromatin IP Primers for RTKN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RTKN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.1   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p13.1

RTKN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTKN gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M074660:  view genomic region     (about GC identifiers)

Start:
74,652,963 bp from pter      End:
74,669,549 bp from pter
Size:
16,587 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RTKN_HUMAN, Q9BST9 (See protein sequence)
Recommended Name: Rhotekin  
Size: 563 amino acids; 62667 Da
Subunit: Interacts via its C-terminal region with the TAX1BP3 PDZ domain. This interaction facilitates
Rho-mediated activation of the c-Fos serum response element (SRE). Interacts with SEPT9. Specifically binds to
GTP-bound RHOA, RHOB and RHOC and inhibits their GTPase activity
Sequence caution: Sequence=AAL16767.1; Type=Frameshift; Positions=15, 20;
Secondary accessions: H7BXD4 Q8WVN1 Q96PT6 Q9HB05
Alternative splicing: 3 isoforms:  Q9BST9-1   Q9BST9-2   Q9BST9-3   (Incomplete sequence)

Explore the universe of human proteins at neXtProt for RTKN: NX_Q9BST9

Explore proteomics data for RTKN at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BST9

  • RTKN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RTKN Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001015055.1  NP_001015056.1  NP_149035.1  

    ENSEMBL proteins: 
     ENSP00000305298   ENSP00000272430   ENSP00000233330  

    Human Recombinant Protein Products for RTKN: 
    EMD Millipore Purified and/or Recombinant RTKN Protein
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    OriGene Protein Over-expression Lysate for RTKN
    OriGene MassSpec for RTKN 
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    Novus Biologicals RTKN Protein
    Novus Biologicals RTKN Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RTKN 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    RTKN for ontologies           About GeneDecksing



    RTKN Antibody Products: 
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    Cloud-Clone Corp. CLIAs for RTKN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing

    4 InterPro protein domains:
     IPR011072 HR1_rho-bd
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR012966 DUF1709

    Graphical View of Domain Structure for InterPro Entry Q9BST9

    ProtoNet protein and cluster: Q9BST9

    2 Blocks protein domains:
    IPB001849 Pleckstrin-like
    IPB011072 Protein kinase PKN/PRK1


    UniProtKB/Swiss-Prot: RTKN_HUMAN, Q9BST9
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 REM (Hr1) repeat


    RTKN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RTKN_HUMAN, Q9BST9
    Function: Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells
    in gastric tumorigenesis. May play a novel role in the organization of septin structures

         Genatlas biochemistry entry for RTKN:
    rhotekin,61kDa,expressed in many tissues including brain,muscle,binding GTP bound form of Rho inhibiting its
    GTPase activity

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005095GTPase inhibitor activity IDA10940294
    GO:0005515protein binding IPI10940294
    GO:0005525GTP binding IEA--
    GO:0005543phospholipid binding IEA--
    GO:0017048Rho GTPase binding ----
         
    RTKN for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RTKN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RTKN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RTKN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RTKN 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RTKN
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate RTKN (see all 24):
    hsa-miR-1321 hsa-let-7d hsa-miR-4328 hsa-miR-301a hsa-let-7c hsa-miR-520a-5p hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidRTKN 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): RTKN (NM_001015055)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTKN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RTKN About                                                                                                See pathways by source

    SuperPathContained pathways About
    1G-protein signaling RhoB regulation pathway
    G-protein signaling RhoB regulation pathway1.00
    2Actin Nucleation by ARP-WASP Complex
    RhoA Pathway0.35
    3Alpha6-Beta4 Integrin Signaling Pathway
    Alpha6-Beta4 Integrin Signaling Pathway
    4G13 Signaling Pathway
    G13 Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RTKN
        G-protein signaling RhoB regulation pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RTKN
        RhoA Pathway

    1 GeneGo (Thomson Reuters) Pathway for RTKN
        G-protein signaling RhoB regulation pathway

    2 BioSystems Pathways for RTKN
        G13 Signaling Pathway
    Alpha6-Beta4 Integrin Signaling Pathway




    RTKN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RTKN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/19 Interacting proteins for RTKN (Q9BST92, 3 ENSP000002724304) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SORBS3O605042, 3, ENSP000002401234MINT-7215715 MINT-7215651 MINT-7215594 MINT-7215608 MINT-7215695 MINT-7215670 I2D: score=1 STRING: ENSP00000240123
    RHOAP615862, 3, ENSP000004001754MINT-6504377 MINT-7301170 MINT-7146266 MINT-8378406 MINT-8380722 I2D: score=8 STRING: ENSP00000400175
    RAC1P630002, 3, ENSP000003484614MINT-6504419 I2D: score=1 STRING: ENSP00000348461
    SMURF1Q9HCE73, ENSP000003546214I2D: score=2 STRING: ENSP00000354621
    TAX1BP3O149073, ENSP000002255254I2D: score=2 STRING: ENSP00000225525
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction IDA10940294
    GO:0007266Rho protein signal transduction IDA15480428

    RTKN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RTKN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RTKN

    1 HMDB Compound for RTKN    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 Novoseek inferred chemical compound relationships for RTKN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    butyrate 38.6 4 15480428 (1)
    serine 5.98 1 10940294 (1)

    Search CenterWatch for drugs/clinical trials and news about RTKN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RTKN gene (3 alternative transcripts): 
    NM_001015055.1  NM_001015056.1  NM_033046.2  

    Unigene Cluster for RTKN:

    Rhotekin
    Hs.192854  [show with all ESTs]
    Unigene Representative Sequence: NM_033046
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305557(uc002slc.3 uc002sld.3) ENST00000272430(uc002sle.3)
    ENST00000233330 ENST00000492013 ENST00000469859 ENST00000479256 ENST00000472518(uc010ffe.1 uc010ffg.1)
    ENST00000464094(uc010fff.1) ENST00000460968 ENST00000484453

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RTKN
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate RTKN (see all 24):
    hsa-miR-1321 hsa-let-7d hsa-miR-4328 hsa-miR-301a hsa-let-7c hsa-miR-520a-5p hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidRTKN 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RTKN
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RTKN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTKN
    Sirion Biotech Customized lentivirus for stable overexpression of RTKN 
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    OriGene qPCR primer pairs and template standards for RTKN
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RTKN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RTKN

    Additional mRNA sequence: 

    AF049227.1 AF290512.1 AK307302.1 AK308519.1 AK310036.1 BC004558.2 BC017727.1 

    13 DOTS entries:

    DT.444757  DT.308997  DT.100813635  DT.95323126  DT.100813632  DT.100813631  DT.120962463  DT.91816878 
    DT.100813627  DT.102825351  DT.92027421  DT.95323124  DT.75114775 

    24/236 AceView cDNA sequences (see all 236):

    BM666431 BM555731 AI061102 BC004558 BU521885 BC017727 BM799779 AA366268 
    BU542771 BM544606 BQ225902 BM795548 BG818751 CA946352 AI880313 BF594415 
    BI712161 BM921551 AA341645 BQ006183 BQ936904 BU165989 BM272585 CA848925 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RTKN (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a ·
    SP1:                    -     -     -     -                       -     -     -                                                           -                     
    SP2:                                                              -     -     -                                                           -                     
    SP3:                                -     -                       -     -     -                                                                                 
    SP4:                                                              -     -     -     -                                                                           
    SP5:                                                                                                                          -           -                     

    ExUns: 15b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for RTKN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RTKN expression in normal human tissues (normalized intensities)      RTKN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACCGAGGG
    RTKN Expression
    About this image


    RTKN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Cartilage (Muscoskeletal System)
             fetal cartilage   
     
     Brain (Nervous System)
             corpus callosum   

     -- (Nervous System)
             nodose nucleus   

    See RTKN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RTKN

    SOURCE GeneReport for Unigene cluster: Hs.192854

    UniProtKB/Swiss-Prot: RTKN_HUMAN, Q9BST9
    Tissue specificity: Highly expressed in prostate, moderately in kidney, heart, brain, spleen, testis, placenta,
    small intestine, pancreas, skeletal muscle and peripheral blood leukocytes, and weakly in ovary, colon and
    thymus. Weakly expressed in all normal cell lines tested. Overexpressed in various cancer cell lines

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTKN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RTKN gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rtkn1 , 5 rhotekin1, 5 87.21(n)1
    86.86(a)1
      6 (35.94 cM)5
    201661  NM_001136227.11  NP_001129699.11 
     831354635 
    lizard
    (Anolis carolinensis)
    Reptilia RTKN6
    --
    Uncharacterized protein
    56(a)
    49(a)
    1 ↔ 1
    possible ortholog
    GL344233.1(39717-53822)
    GL344264.1(9655-12841)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ043112.12   -- 75.4(n)    BJ043112.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM571991.12   -- 73.33(n)    BM571991.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C07B5.46
    Protein C07B5.4, isoform a
    18(a)
    1 → many
    X(9529533-9536634)


    ENSEMBL Gene Tree for RTKN (if available)
    TreeFam Gene Tree for RTKN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RTKN gene
    RTKN22  
    1 SIMAP similar gene for RTKN using alignment to 1 protein entry:     RTKN_HUMAN:
    RTKN2

    RTKN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/425 SNPs in RTKN are shown (see all 425)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2013471981,2
    --74653395(+) AAGTGC/TGAGGT 6 H R mis10--------
    rs2000434861,2
    C--74653398(+) TGCGAG/AGTTGG 6 /P /L mis11Minor allele frequency- A:0.00EU 751
    rs767722551,2
    C,F--74653400(+) CGAGGT/CTGGCC 6 /Q syn12Minor allele frequency- C:0.04WA NA 4106
    rs1428422511,2
    C,F--74653413(+) TGCTGC/TAGAGG 6 Y C mis11Minor allele frequency- T:0.00NA 4038
    rs1423664891,2
    --74653480(+) GGAGTA/GGTCTG 6 H Y mis10--------
    rs2005473331,2
    --74653598(+) GGCTGG/TTCTGT 6 E D mis10--------
    rs1996737041,2
    --74653615(+) TGCCAG/TCCAGG 6 M L mis10--------
    rs1459496531,2
    C,F--74653642(+) CCTTGC/TGCCCT 6 T A mis11Minor allele frequency- T:0.00NA 3640
    rs2016335311,2
    --74653643(+) CTTGCA/GCCCTC 6 G syn10--------
    rs750082081,2
    C,F--74653661(+) GTCAGG/TATGTC 6 I syn12Minor allele frequency- T:0.00NA EU 4595

    HapMap Linkage Disequilibrium report for RTKN (74652963 - 74669549 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RTKN:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv458185CNV Loss19166990
    nsv515851CNV Loss19592680
    dgv4166n71CNV Loss21882294
    dgv1199e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602288    OMIM disorders: --

    15 diseases for RTKN:    About MalaCards
    amyotrophic neuralgia    hereditary neuralgic amyotrophy    gastric adenocarcinoma    bladder carcinoma
    pancreatic cancer    adenocarcinoma    alzheimer's disease    gastric cancer
    pancreatitis    prostate cancer    prostatitis    endotheliitis
    breast cancer    leukemia    neuronitis


    RTKN for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for RTKN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastric cancer 16.9 3 15480428 (1)
    metastasis 9.84 2 15316142 (1)


    Export disorders for RTKN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RTKN gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with RTKN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element. (PubMed id 10940294)1, 2, 3, 9 Reynaud C.... Jalinot P. (2000)
    2. Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis. (PubMed id 15480428)1, 2, 9 Liu C.-A.... Chen J.-Y. (2004)
    3. Molecular cloning, expression characterization, and mapping of a novel putative inhibitor of rho GTPase activity, RTKN, to D2S145- D2S286. (PubMed id 10873388)1, 2, 9 Fu Q.... Zhao S. (2000)
    4. Possible role of Rho/Rhotekin signaling in mammalian septin organization. (PubMed id 16007136)1, 2 Ito H....Nagata K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Localization of the rhotekin gene RTKN on the physical maps of mouse chromosome 6 and human chromosome 2p13 and exclusion as a candidate for mnd2 and LGMD2B. (PubMed id 9073523)1, 3 Jang W....Meisler M.H. (1997)
    7. Overexpression of rho effector rhotekin confers increased survival in gastric adenocarcinoma. (PubMed id 15316142)1, 9 Liu C.A....Chen J.Y. (2004)
    8. Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons. (PubMed id 16979770)1, 9 Sudo K.... Nagata K. (2006)
    9. Interaction of a multi-domain adaptor protein, vinexin, with a Rho-effector, Rhotekin. (PubMed id 19294487)1, 9 Nagata K....Asano T. (2009)
    10. Protein kinase D regulates RhoA activity via rhotekin phosphorylation. (PubMed id 22228765)1 Pusapati G.V....Seufferlein T. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6242 HGNC: 10466 AceView: RTKN Ensembl:ENSG00000114993 euGenes: HUgn6242
    ECgene: RTKN H-InvDB: RTKN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RTKN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RTKN gene:
    Search GeneIP for patents involving RTKN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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