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Aliases for RTFDC1 Gene

Aliases for RTFDC1 Gene

  • Replication Termination Factor 2 Domain Containing 1 2 3 5
  • Replication Termination Factor 2 Domain-Containing Protein 1 3 4
  • C20orf43 3 4
  • Chromosome 20 Open Reading Frame 43 2
  • UPF0549 Protein C20orf43 3
  • SHUJUN-3 3
  • HSPC164 3
  • CDAO5 3

External Ids for RTFDC1 Gene

Previous HGNC Symbols for RTFDC1 Gene

  • C20orf43

Previous GeneCards Identifiers for RTFDC1 Gene

  • GC20P055045

Summaries for RTFDC1 Gene

GeneCards Summary for RTFDC1 Gene

RTFDC1 (Replication Termination Factor 2 Domain Containing 1) is a Protein Coding gene.

Gene Wiki entry for RTFDC1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTFDC1 Gene

Genomics for RTFDC1 Gene

Regulatory Elements for RTFDC1 Gene

Enhancers for RTFDC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RTFDC1 on UCSC Golden Path with GeneCards custom track

Promoters for RTFDC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RTFDC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RTFDC1 Gene

Chromosome:
20
Start:
56,468,585 bp from pter
End:
56,519,449 bp from pter
Size:
50,865 bases
Orientation:
Plus strand

Genomic View for RTFDC1 Gene

Genes around RTFDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTFDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTFDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTFDC1 Gene

Proteins for RTFDC1 Gene

  • Protein details for RTFDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY42-RTF2_HUMAN
    Recommended name:
    Protein RTF2 homolog
    Protein Accession:
    Q9BY42
    Secondary Accessions:
    • E1P5Z9
    • Q9BYL7
    • Q9HCV9
    • Q9NX29
    • Q9NZZ8
    • Q9P002
    • Q9UHW3

    Protein attributes for RTFDC1 Gene

    Size:
    306 amino acids
    Molecular mass:
    33887 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RTFDC1 Gene

Proteomics data for RTFDC1 Gene at MOPED

Post-translational modifications for RTFDC1 Gene

  • Ubiquitination at Lys 59
  • Modification sites at PhosphoSitePlus

Other Protein References for RTFDC1 Gene

No data available for DME Specific Peptides for RTFDC1 Gene

Domains & Families for RTFDC1 Gene

Protein Domains for RTFDC1 Gene

Suggested Antigen Peptide Sequences for RTFDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BY42

UniProtKB/Swiss-Prot:

RTF2_HUMAN :
  • Belongs to the rtf2 family.
Family:
  • Belongs to the rtf2 family.
genes like me logo Genes that share domains with RTFDC1: view

No data available for Gene Families for RTFDC1 Gene

Function for RTFDC1 Gene

Phenotypes for RTFDC1 Gene

genes like me logo Genes that share phenotypes with RTFDC1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RTFDC1 Gene

Localization for RTFDC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RTFDC1 Gene COMPARTMENTS Subcellular localization image for RTFDC1 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 1
extracellular 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RTFDC1 Gene

Pathways & Interactions for RTFDC1 Gene

SuperPathways for RTFDC1 Gene

No Data Available

Interacting Proteins for RTFDC1 Gene

Gene Ontology (GO) - Biological Process for RTFDC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RTFDC1 Gene

Drugs & Compounds for RTFDC1 Gene

No Compound Related Data Available

Transcripts for RTFDC1 Gene

Unigene Clusters for RTFDC1 Gene

Replication termination factor 2 domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RTFDC1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: -
SP2: - - - - -
SP3: -

Relevant External Links for RTFDC1 Gene

GeneLoc Exon Structure for
RTFDC1
ECgene alternative splicing isoforms for
RTFDC1

Expression for RTFDC1 Gene

mRNA expression in normal human tissues for RTFDC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RTFDC1 Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for RTFDC1 Gene

This gene is overexpressed in Breast (23.1), Adrenal (12.8), and Peripheral blood mononuclear cells (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RTFDC1 Gene



SOURCE GeneReport for Unigene cluster for RTFDC1 Gene Hs.517134

genes like me logo Genes that share expression patterns with RTFDC1: view

Protein tissue co-expression partners for RTFDC1 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RTFDC1 Gene

Orthologs for RTFDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RTFDC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RTFDC1 35
  • 89.97 (n)
  • 92.98 (a)
RTFDC1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RTFDC1 35
  • 88.85 (n)
  • 91.48 (a)
RTFDC1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rtfdc1 35
  • 84.1 (n)
  • 87.58 (a)
Rtfdc1 16
Rtfdc1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RTFDC1 35
  • 99.24 (n)
  • 99.35 (a)
RTFDC1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rtfdc1 35
  • 83.77 (n)
  • 88.24 (a)
oppossum
(Monodelphis domestica)
Mammalia RTFDC1 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RTFDC1 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves C20H20ORF43 35
  • 67.98 (n)
  • 69.51 (a)
RTFDC1 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RTFDC1 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rtfdc1 35
  • 68.11 (n)
  • 68.44 (a)
Str.6685 35
African clawed frog
(Xenopus laevis)
Amphibia MGC64388 35
zebrafish
(Danio rerio)
Actinopterygii rtfdc1 35
  • 63.05 (n)
  • 59.21 (a)
wufd99e08 35
rtfdc1 36
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012690 35
  • 50.58 (n)
  • 45.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6443 35
  • 51.95 (n)
  • 42.41 (a)
CG6443 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C01A2.5 35
  • 49.03 (n)
  • 40.21 (a)
C01A2.5 36
  • 35 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2260 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4832 36
  • 37 (a)
OneToOne
Species with no ortholog for RTFDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RTFDC1 Gene

ENSEMBL:
Gene Tree for RTFDC1 (if available)
TreeFam:
Gene Tree for RTFDC1 (if available)

Paralogs for RTFDC1 Gene

No data available for Paralogs for RTFDC1 Gene

Variants for RTFDC1 Gene

Sequence variations from dbSNP and Humsavar for RTFDC1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_028134 -
VAR_028135 -
rs1884421 -- 56,470,108(+) AATAA(A/G)TATGT intron-variant, upstream-variant-2KB
rs910658 -- 56,489,779(+) TGTAA(G/T)CTTTT intron-variant
rs1474890 -- 56,474,852(+) TAAAG(A/G)CTGAA intron-variant

Variation tolerance for RTFDC1 Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.16% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for RTFDC1 Gene

Disorders for RTFDC1 Gene

Relevant External Links for RTFDC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RTFDC1

No disorders were found for RTFDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RTFDC1 Gene

Publications for RTFDC1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus. (PMID: 25130324) Cai D.C. … Hagoort P. (Genes Brain Behav. 2014) 3

Products for RTFDC1 Gene

Sources for RTFDC1 Gene

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