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Aliases for RTFDC1 Gene

Aliases for RTFDC1 Gene

  • Replication Termination Factor 2 Domain Containing 1 2 3
  • Replication Termination Factor 2 Domain-Containing Protein 1 3 4
  • C20orf43 3 4
  • Chromosome 20 Open Reading Frame 43 2
  • UPF0549 Protein C20orf43 3
  • Protein RTF2 Homolog 3
  • SHUJUN-3 3
  • HSPC164 3
  • CDAO5 3
  • P 6

External Ids for RTFDC1 Gene

Previous HGNC Symbols for RTFDC1 Gene

  • C20orf43

Previous GeneCards Identifiers for RTFDC1 Gene

  • GC20P055045

Summaries for RTFDC1 Gene

GeneCards Summary for RTFDC1 Gene

RTFDC1 (Replication Termination Factor 2 Domain Containing 1) is a Protein Coding gene.

Gene Wiki entry for RTFDC1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTFDC1 Gene

Genomics for RTFDC1 Gene

Genomic Location for RTFDC1 Gene

56,468,585 bp from pter
56,519,449 bp from pter
50,865 bases
Plus strand

Genomic View for RTFDC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RTFDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTFDC1 Gene

No data available for Regulatory Elements for RTFDC1 Gene

Proteins for RTFDC1 Gene

  • Protein details for RTFDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein RTF2 homolog
    Protein Accession:
    Secondary Accessions:
    • E1P5Z9
    • Q9BYL7
    • Q9HCV9
    • Q9NX29
    • Q9NZZ8
    • Q9P002
    • Q9UHW3

    Protein attributes for RTFDC1 Gene

    306 amino acids
    Molecular mass:
    33887 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RTFDC1 Gene

Proteomics data for RTFDC1 Gene at MOPED

Post-translational modifications for RTFDC1 Gene

  • Ubiquitination at Lys59
  • Modification sites at PhosphoSitePlus

Other Protein References for RTFDC1 Gene

No data available for DME Specific Peptides for RTFDC1 Gene

Domains for RTFDC1 Gene

Protein Domains for RTFDC1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9BY42
  • Belongs to the rtf2 family.
genes like me logo Genes that share domains with RTFDC1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for RTFDC1 Gene

Function for RTFDC1 Gene

Gene Ontology (GO) - Molecular Function for RTFDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with RTFDC1: view

Phenotypes for RTFDC1 Gene

GenomeRNAi human phenotypes for RTFDC1:
genes like me logo Genes that share phenotypes with RTFDC1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RTFDC1 Gene

Localization for RTFDC1 Gene

Gene Ontology (GO) - Cellular Components for RTFDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with RTFDC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for RTFDC1 Gene

Pathways for RTFDC1 Gene

SuperPathways for RTFDC1 Gene

No Data Available

Interacting Proteins for RTFDC1 Gene

Gene Ontology (GO) - Biological Process for RTFDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with RTFDC1: view

No data available for Pathways by source for RTFDC1 Gene

Transcripts for RTFDC1 Gene

Unigene Clusters for RTFDC1 Gene

Replication termination factor 2 domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RTFDC1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: -
SP2: - - - - -
SP3: -

Relevant External Links for RTFDC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RTFDC1 Gene

mRNA expression in normal human tissues for RTFDC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RTFDC1 Gene

This gene is overexpressed in Whole Blood (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RTFDC1 Gene

SOURCE GeneReport for Unigene cluster for RTFDC1 Gene Hs.517134

genes like me logo Genes that share expressions with RTFDC1: view

No data available for mRNA Expression by UniProt/SwissProt for RTFDC1 Gene

Orthologs for RTFDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RTFDC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RTFDC1 35
  • 99.24 (n)
  • 99.35 (a)
  • 99 (a)
(Bos Taurus)
Mammalia RTFDC1 35
  • 89.97 (n)
  • 92.98 (a)
  • 93 (a)
(Canis familiaris)
Mammalia RTFDC1 35
  • 88.85 (n)
  • 91.48 (a)
  • 91 (a)
(Mus musculus)
Mammalia Rtfdc1 35
  • 84.1 (n)
  • 87.58 (a)
Rtfdc1 16
Rtfdc1 36
  • 88 (a)
(Monodelphis domestica)
Mammalia RTFDC1 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia RTFDC1 36
  • 59 (a)
(Rattus norvegicus)
Mammalia Rtfdc1 35
  • 83.77 (n)
  • 88.24 (a)
(Gallus gallus)
Aves C20H20ORF43 35
  • 67.98 (n)
  • 69.51 (a)
  • 69 (a)
(Anolis carolinensis)
Reptilia RTFDC1 36
  • 71 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC64388 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rtfdc1 35
  • 68.11 (n)
  • 68.44 (a)
Str.6685 35
(Danio rerio)
Actinopterygii rtfdc1 35
  • 63.05 (n)
  • 59.21 (a)
rtfdc1 36
  • 56 (a)
wufd99e08 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012690 35
  • 50.58 (n)
  • 45.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6443 35
  • 51.95 (n)
  • 42.41 (a)
CG6443 36
  • 40 (a)
(Caenorhabditis elegans)
Secernentea C01A2.5 35
  • 49.03 (n)
  • 40.21 (a)
C01A2.5 36
  • 35 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2260 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4832 36
  • 37 (a)
Species with no ortholog for RTFDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RTFDC1 Gene

Gene Tree for RTFDC1 (if available)
Gene Tree for RTFDC1 (if available)

Paralogs for RTFDC1 Gene

No data available for Paralogs for RTFDC1 Gene

Variants for RTFDC1 Gene

Sequence variations from dbSNP and Humsavar for RTFDC1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs910658 -- 56,489,779(+) TGTAA(G/T)CTTTT intron-variant
rs1474890 -- 56,474,852(+) TAAAG(A/G)CTGAA intron-variant
rs1884421 -- 56,470,108(+) AATAA(A/G)TATGT intron-variant
rs2273327 -- 56,477,291(+) TTTCC(A/G)TCAGC intron-variant
rs3044252 -- 56,469,784(+) CATCT(-/TCT)GCCCC intron-variant

Relevant External Links for RTFDC1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RTFDC1 Gene

Disorders for RTFDC1 Gene

No disorders were found for RTFDC1 Gene.

No data available for UniProtKB/Swiss-Prot for RTFDC1 Gene

Publications for RTFDC1 Gene

  1. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for RTFDC1 Gene

Sources for RTFDC1 Gene

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