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Aliases for RTF2 Gene

Aliases for RTF2 Gene

  • Replication Termination Factor 2 2 3
  • Replication Termination Factor 2 Domain Containing 1 2 3 5
  • RTFDC1 3 4 5
  • Replication Termination Factor 2 Domain-Containing Protein 1 3 4
  • C20orf43 3 4
  • Chromosome 20 Open Reading Frame 43 2
  • UPF0549 Protein C20orf43 3
  • Protein RTF2 Homolog 3
  • SHUJUN-3 3
  • HSPC164 3
  • CDAO5 3

External Ids for RTF2 Gene

Previous HGNC Symbols for RTF2 Gene

  • C20orf43
  • RTFDC1

Summaries for RTF2 Gene

GeneCards Summary for RTF2 Gene

RTF2 (Replication Termination Factor 2) is a Protein Coding gene.

Gene Wiki entry for RTF2 Gene

Additional gene information for RTF2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTF2 Gene

Genomics for RTF2 Gene

GeneHancer (GH) Regulatory Elements for RTF2 Gene

Promoters and enhancers for RTF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I056467 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 558.1 +0.3 331 3 HDGF PKNOX1 MLX ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B IRF4 RTF2 LOC105372681
GH20I056408 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 29.6 -51.5 -51471 17 HNRNPUL1 PKNOX1 SMAD1 FOXA2 ARNT ZFP64 YBX1 YY1 POLR2B ZNF766 CASS4 RTF2 RPL39P CSTF1 ENSG00000280387 FAM210B GCNT7 FAM209B
GH20I056432 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 18.1 -34.3 -34281 3.8 ZFHX2 EGR1 ZMYM3 ZNF24 SPI1 EGR2 CASS4 RTF2 RPL39P
GH20I056436 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 15.2 -27.7 -27713 8.4 PKNOX1 FOXA2 EBF1 IRF4 RELA E2F1 GATA3 POLR2A NFATC1 SCRT2 CASS4 RTF2 FAM209A RPL39P
GH20I056426 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.1 -39.7 -39659 5.8 HDAC1 NCOA2 TCF12 EGR1 FOS ETV6 CREM EGR2 SMARCA5 ZBTB2 CASS4 RTF2 RPL39P FAM209A FAM210B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RTF2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RTF2 Gene

Genomic Locations for RTF2 Gene
chr20:56,468,585-56,519,449
(GRCh38/hg38)
Size:
50,865 bases
Orientation:
Plus strand
chr20:55,043,647-55,093,943
(GRCh37/hg19)

Genomic View for RTF2 Gene

Genes around RTF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RTF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RTF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTF2 Gene

Proteins for RTF2 Gene

  • Protein details for RTF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY42-RTF2_HUMAN
    Recommended name:
    Protein RTF2 homolog
    Protein Accession:
    Q9BY42
    Secondary Accessions:
    • E1P5Z9
    • Q9BYL7
    • Q9HCV9
    • Q9NX29
    • Q9NZZ8
    • Q9P002
    • Q9UHW3

    Protein attributes for RTF2 Gene

    Size:
    306 amino acids
    Molecular mass:
    33887 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RTF2 Gene

Post-translational modifications for RTF2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RTF2 Gene

Domains & Families for RTF2 Gene

Gene Families for RTF2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RTF2 Gene

Suggested Antigen Peptide Sequences for RTF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BY42

UniProtKB/Swiss-Prot:

RTF2_HUMAN :
  • Belongs to the rtf2 family.
Family:
  • Belongs to the rtf2 family.
genes like me logo Genes that share domains with RTF2: view

Function for RTF2 Gene

Phenotypes From GWAS Catalog for RTF2 Gene

Gene Ontology (GO) - Molecular Function for RTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with RTF2: view

Phenotypes for RTF2 Gene

genes like me logo Genes that share phenotypes with RTF2: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RTF2 Gene

Localization for RTF2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RTF2 gene
Compartment Confidence
nucleus 5
mitochondrion 2
plasma membrane 1
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with RTF2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RTF2 Gene

Pathways & Interactions for RTF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0071171 site-specific DNA replication termination at RTS1 barrier IBA --
GO:1902979 mitotic DNA replication termination IEA --
genes like me logo Genes that share ontologies with RTF2: view

No data available for Pathways by source and SIGNOR curated interactions for RTF2 Gene

Drugs & Compounds for RTF2 Gene

No Compound Related Data Available

Transcripts for RTF2 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTF2 Gene

No ASD Table

Relevant External Links for RTF2 Gene

GeneLoc Exon Structure for
RTF2
ECgene alternative splicing isoforms for
RTF2

Expression for RTF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RTF2 Gene:

RTF2

Evidence on tissue expression from TISSUES for RTF2 Gene

  • Nervous system(4.6)
  • Blood(4.4)
  • Adrenal gland(4.3)
  • Skin(3.6)
  • Lung(3.2)
  • Intestine(2.9)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RTF2 Gene

Orthologs for RTF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RTF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RTFDC1 33 34
  • 99.24 (n)
cow
(Bos Taurus)
Mammalia RTFDC1 33 34
  • 89.97 (n)
dog
(Canis familiaris)
Mammalia RTFDC1 33 34
  • 88.85 (n)
mouse
(Mus musculus)
Mammalia Rtfdc1 33 34
  • 84.1 (n)
Rtf2 16
rat
(Rattus norvegicus)
Mammalia Rtfdc1 33
  • 83.77 (n)
oppossum
(Monodelphis domestica)
Mammalia RTFDC1 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RTFDC1 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves RTFDC1 34
  • 69 (a)
OneToOne
C20H20ORF43 33
  • 67.98 (n)
lizard
(Anolis carolinensis)
Reptilia RTFDC1 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rtfdc1 33
  • 68.11 (n)
Str.6685 33
African clawed frog
(Xenopus laevis)
Amphibia MGC64388 33
zebrafish
(Danio rerio)
Actinopterygii rtfdc1 33 34
  • 63.05 (n)
wufd99e08 33
fruit fly
(Drosophila melanogaster)
Insecta CG6443 33 34
  • 51.95 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010176 33
  • 50.58 (n)
worm
(Caenorhabditis elegans)
Secernentea C01A2.5 33 34
  • 49.03 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4832 34
  • 37 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2260 33
Species where no ortholog for RTF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RTF2 Gene

ENSEMBL:
Gene Tree for RTF2 (if available)
TreeFam:
Gene Tree for RTF2 (if available)

Paralogs for RTF2 Gene

No data available for Paralogs for RTF2 Gene

Variants for RTF2 Gene

Sequence variations from dbSNP and Humsavar for RTF2 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000143480 -- 56,492,244(+) A/G intron_variant
rs1000220069 -- 56,489,307(+) A/C intron_variant
rs1000233454 -- 56,480,694(+) A/G intron_variant
rs1000319060 -- 56,512,968(+) A/G intron_variant
rs1000326944 -- 56,491,566(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RTF2 Gene

Variant ID Type Subtype PubMed ID
dgv787e214 CNV gain 21293372
esv2722575 CNV deletion 23290073
esv29810 CNV gain 19812545
esv3646189 CNV loss 21293372
nsv1056574 CNV gain 25217958
nsv525425 CNV gain 19592680
nsv834013 CNV gain 17160897
nsv834015 CNV loss 17160897

Variation tolerance for RTF2 Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RTF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RTF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTF2 Gene

Disorders for RTF2 Gene

Additional Disease Information for RTF2

No disorders were found for RTF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RTF2 Gene

Publications for RTF2 Gene

  1. Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity. (PMID: 29290612) Kottemann MC … Smogorzewska A (Molecular cell 2018) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu RM … Chen JL (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 58

Products for RTF2 Gene

Sources for RTF2 Gene

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