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Aliases for RTEL1-TNFRSF6B Gene

Subcategory (RNA class) for RTEL1-TNFRSF6B Gene


Quality Score for this RNA gene is


Aliases for RTEL1-TNFRSF6B Gene

  • RTEL1-TNFRSF6B Readthrough (NMD Candidate) 2 3
  • Decoy Receptor For Fas Ligand 4
  • Decoy Receptor 3 4
  • TNFRSF6B 4
  • DCR3 4
  • M68 4
  • TR6 4

External Ids for RTEL1-TNFRSF6B Gene

Previous GeneCards Identifiers for RTEL1-TNFRSF6B Gene

  • GC20U900647
  • GC20P062291

Summaries for RTEL1-TNFRSF6B Gene

Entrez Gene Summary for RTEL1-TNFRSF6B Gene

  • This locus represents naturally occurring read-through transcription between the neighboring RTEL1 (regulator of telomere elongation helicase 1) and TNFRSF6B (tumor necrosis factor receptor superfamily, member 6b, decoy) genes on chromosome 20. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, Feb 2011]

GeneCards Summary for RTEL1-TNFRSF6B Gene

RTEL1-TNFRSF6B (RTEL1-TNFRSF6B Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. Diseases associated with RTEL1-TNFRSF6B include ulcerative colitis. An important paralog of this gene is BRIP1.

UniProtKB/Swiss-Prot for RTEL1-TNFRSF6B Gene

  • Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTEL1-TNFRSF6B Gene

Genomics for RTEL1-TNFRSF6B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RTEL1-TNFRSF6B Gene

63,657,810 bp from pter
63,698,698 bp from pter
40,889 bases
Plus strand

Genomic View for RTEL1-TNFRSF6B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RTEL1-TNFRSF6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTEL1-TNFRSF6B Gene

No data available for Regulatory Elements for RTEL1-TNFRSF6B Gene

Proteins for RTEL1-TNFRSF6B Gene

  • Protein details for RTEL1-TNFRSF6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 6B
    Protein Accession:
    Secondary Accessions:

    Protein attributes for RTEL1-TNFRSF6B Gene

    300 amino acids
    Molecular mass:
    32680 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RTEL1-TNFRSF6B Gene

neXtProt entry for RTEL1-TNFRSF6B Gene

Proteomics data for RTEL1-TNFRSF6B Gene at MOPED

Protein Expression for RTEL1-TNFRSF6B Gene

Post-translational modifications for RTEL1-TNFRSF6B Gene

  • Glycosylation at Asn173
  • Modification sites at PhosphoSitePlus

Other Protein References for RTEL1-TNFRSF6B Gene

No data available for DME Specific Peptides for RTEL1-TNFRSF6B Gene

Domains for RTEL1-TNFRSF6B Gene

Protein Domains for RTEL1-TNFRSF6B Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 TNFR-Cys repeats.
  • Contains 4 TNFR-Cys repeats.
genes like me logo Genes that share domains with RTEL1-TNFRSF6B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for RTEL1-TNFRSF6B Gene

Function for RTEL1-TNFRSF6B Gene

Molecular function for RTEL1-TNFRSF6B Gene

UniProtKB/Swiss-Prot Function:
Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.

Gene Ontology (GO) - Molecular Function for RTEL1-TNFRSF6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding --
GO:0004003 ATP-dependent DNA helicase activity --
GO:0004872 receptor activity --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with RTEL1-TNFRSF6B: view

Phenotypes for RTEL1-TNFRSF6B Gene

GenomeRNAi human phenotypes for RTEL1-TNFRSF6B:
genes like me logo Genes that share phenotypes with RTEL1-TNFRSF6B: view


miRTarBase miRNAs that target RTEL1-TNFRSF6B

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RTEL1-TNFRSF6B Gene

Localization for RTEL1-TNFRSF6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTEL1-TNFRSF6B Gene


Gene Ontology (GO) - Cellular Components for RTEL1-TNFRSF6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space --
GO:0005634 nucleus --
genes like me logo Genes that share ontologies with RTEL1-TNFRSF6B: view

No data available for Subcellular locations from COMPARTMENTS for RTEL1-TNFRSF6B Gene

Pathways for RTEL1-TNFRSF6B Gene

SuperPathways for RTEL1-TNFRSF6B Gene

No Data Available

Interacting Proteins for RTEL1-TNFRSF6B Gene

Gene Ontology (GO) - Biological Process for RTEL1-TNFRSF6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process --
GO:0006200 obsolete ATP catabolic process --
GO:0006915 apoptotic process --
GO:0032508 DNA duplex unwinding --
GO:0043066 negative regulation of apoptotic process --
genes like me logo Genes that share ontologies with RTEL1-TNFRSF6B: view

No data available for Pathways by source for RTEL1-TNFRSF6B Gene

Transcripts for RTEL1-TNFRSF6B Gene


(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RTEL1-TNFRSF6B Gene

No ASD Table

Relevant External Links for RTEL1-TNFRSF6B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RTEL1-TNFRSF6B Gene

mRNA expression in normal human tissues for RTEL1-TNFRSF6B Gene

Protein differential expression in normal tissues for RTEL1-TNFRSF6B Gene

This gene is overexpressed in Breast (41.3) and Cervix (27.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RTEL1-TNFRSF6B Gene

mRNA Expression by UniProt/SwissProt for RTEL1-TNFRSF6B Gene

Tissue specificity: Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells
genes like me logo Genes that share expressions with RTEL1-TNFRSF6B: view

Expression partners for RTEL1-TNFRSF6B Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RTEL1-TNFRSF6B Gene

Orthologs for RTEL1-TNFRSF6B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RTEL1-TNFRSF6B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RTEL1 36
  • 87 (a)
(Canis familiaris)
Mammalia -- 36
  • 77 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 63 (a)
(Mus musculus)
Mammalia Rtel1 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
-- 36
  • 53 (a)
(Pan troglodytes)
Mammalia -- 36
  • 98 (a)
(Gallus gallus)
Aves -- 36
  • 56 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 57 (a)
(Danio rerio)
Actinopterygii rtel1 36
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4078 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea rtel-1 36
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CHL1 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for RTEL1-TNFRSF6B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RTEL1-TNFRSF6B Gene

Gene Tree for RTEL1-TNFRSF6B (if available)
Gene Tree for RTEL1-TNFRSF6B (if available)

Paralogs for RTEL1-TNFRSF6B Gene

Paralogs for RTEL1-TNFRSF6B Gene

(2) SIMAP similar genes for RTEL1-TNFRSF6B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RTEL1-TNFRSF6B: view

Variants for RTEL1-TNFRSF6B Gene

Structural Variations from Database of Genomic Variants (DGV) for RTEL1-TNFRSF6B Gene

Variant ID Type Subtype PubMed ID
dgv4618n71 CNV Loss 21882294
nsv913190 CNV Loss 21882294
dgv1344e1 CNV Complex 17122850
nsv913213 CNV Loss 21882294
nsv470563 CNV Loss 18288195
dgv4641n71 CNV Loss 21882294
dgv4644n71 CNV Loss 21882294
dgv1345e1 CNV Complex 17122850
nsv428381 CNV Gain+Loss 18775914
nsv913241 CNV Loss 21882294
nsv9828 CNV Gain+Loss 18304495
esv2722952 CNV Deletion 23290073
esv29168 CNV Loss 19812545
nsv820558 CNV Deletion 20802225
esv988534 CNV Gain 20482838
esv2722953 CNV Deletion 23290073
esv2722954 CNV Deletion 23290073
esv2722955 CNV Deletion 23290073
esv2722956 CNV Deletion 23290073
nsv189 CNV Insertion 15895083
nsv3449 CNV Insertion 18451855
nsv179257 CNV Loss 16902084
esv2006909 CNV Deletion 18987734
esv5108 CNV Deletion 18987735
esv2722957 CNV Deletion 23290073
dgv4645n71 CNV Loss 21882294
dgv4646n71 CNV Loss 21882294
dgv4647n71 CNV Loss 21882294
nsv913249 CNV Loss 21882294
nsv913250 CNV Loss 21882294
esv2722958 CNV Deletion 23290073
esv992110 CNV Insertion 20482838
nsv913253 CNV Loss 21882294

Relevant External Links for RTEL1-TNFRSF6B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RTEL1-TNFRSF6B Gene

Disorders for RTEL1-TNFRSF6B Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for RTEL1-TNFRSF6B Gene in MalaCards »

(1) Disease for RTEL1-TNFRSF6B Gene

genes like me logo Genes that share disorders with RTEL1-TNFRSF6B: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RTEL1-TNFRSF6B Gene

Publications for RTEL1-TNFRSF6B Gene

  1. Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster. (PMID: 10655513) Bai C. … Caskey C.T. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility. (PMID: 19578366) Wrensch M. … Wiencke J.K. (Nat. Genet. 2009) 3
  4. Genome-wide association study identifies five susceptibility loci for glioma. (PMID: 19578367) Shete S. … Houlston R.S. (Nat. Genet. 2009) 3
  5. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3

Products for RTEL1-TNFRSF6B Gene

Sources for RTEL1-TNFRSF6B Gene

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