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RTCA Gene

protein-coding   GIFtS: 43
GCID: GC01P100732

RNA 3'-Terminal Phosphate Cyclase

(Previous names: RTC domain containing 1, RNA terminal phosphate cyclase...)
(Previous symbol: RTCD1)
Microbiology & Infectious Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RNA 3'-Terminal Phosphate Cyclase1 2     RTC Domain-Containing Protein 12 3
RTCD11 2 3 5     RTC Domain Containing 11
RPC2 3 5     EC 6.5.1.43
RNA Terminal Phosphate Cyclase Domain 11 2     RPC13
RTC12 3     RNA Cyclase3
RNA Terminal Phosphate Cyclase Domain-Containing Protein 12 3     RNA-3'-Phosphate Cyclase3

External Ids:    HGNC: 179811   Entrez Gene: 86342   Ensembl: ENSG000001379967   OMIM: 6112865   UniProtKB: O004423   

Export aliases for RTCA gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RTCA Gene:
This gene encodes a member of the RNA 3'-phosphate cyclase family. The encoded protein plays a role in RNA
metabolism by catalyzing the ATP-dependent conversion of the 3'-phosphate of RNA substrates to a 2',3'-cyclic
phosphodiester. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this
gene. (provided by RefSeq, Feb 2012)

GeneCards Summary for RTCA Gene:
RTCA (RNA 3'-terminal phosphate cyclase) is a protein-coding gene. Diseases associated with RTCA include malaria. GO annotations related to this gene include RNA-3'-phosphate cyclase activity and RNA binding. An important paralog of this gene is RCL1.

UniProtKB/Swiss-Prot: RTCA_HUMAN, O00442
Function: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The
mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of
adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus
in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is
likely to function in some aspects of cellular RNA processing




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for RTCA
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRTCA promoter sequence
   Search Chromatin IP Primers for RTCA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RTCA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p21.2   Ensembl cytogenetic band:  1p21.2   HGNC cytogenetic band: 1p13.3

RTCA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RTCA gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P100732:  view genomic region     (about GC identifiers)

Start:
100,731,714 bp from pter      End:
100,758,325 bp from pter
Size:
26,612 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RTCA_HUMAN, O00442 (See protein sequence)
Recommended Name: RNA 3'-terminal phosphate cyclase  
Size: 366 amino acids; 39337 Da
Subunit: Monomer
Secondary accessions: Q5VVL5 Q5VVL6 Q96E99
Alternative splicing: 2 isoforms:  O00442-1   O00442-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RTCA: NX_O00442

Explore proteomics data for RTCA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys163
  • Modification sites at PhosphoSitePlus

  • See RTCA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001124313.1  NP_003720.1  

    ENSEMBL proteins: 
     ENSP00000359146   ENSP00000260563   ENSP00000359144  

    RTCA Human Recombinant Protein Products:

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    Novus Biologicals RTCA Protein
    Novus Biologicals RTCA Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

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    LSBio Antibodies in human, mouse, rat for RTCA

    RTCA Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR013791 RNA3'-term_phos_cycl_insert
     IPR017770 RNA3'_term_phos_cyc_type_1
     IPR020719 RNA3'_term_phos_cycl-like_CS
     IPR023797 RNA3'_phos_cyclase_dom
     IPR000228 RNA3'_term_phos_cyc

    Graphical View of Domain Structure for InterPro Entry O00442

    ProtoNet protein and cluster: O00442

    1 Blocks protein domain: IPB000228 _term_cycl

    UniProtKB/Swiss-Prot: RTCA_HUMAN, O00442
    Similarity: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily


    RTCA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RTCA_HUMAN, O00442
    Function: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The
    mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of
    adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus
    in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is
    likely to function in some aspects of cellular RNA processing
    Catalytic activity: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate

         Enzyme Number (IUBMB): EC 6.5.1.41

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS9184239
    GO:0003824catalytic activity ----
    GO:0003963RNA-3'-phosphate cyclase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    RTCA for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RTCA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RTCA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RTCA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RTCA

    miRNA
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    miRTarBase miRNAs that target RTCA:
    hsa-mir-17-5p (MIRT051005), hsa-let-7b-5p (MIRT032266), hsa-mir-106a-5p (MIRT048340), hsa-mir-615-3p (MIRT040040), hsa-mir-98-5p (MIRT027548)

    Block miRNA regulation of human, mouse, rat RTCA using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RTCA
    SwitchGear 3'UTR luciferase reporter plasmidRTCA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RTCA

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for RTCA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for RTCA
    Sino Biological Human cDNA Clone for RTCA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RTCA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTCA

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTCA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RTCA_HUMAN, O00442: Nucleus, nucleoplasm

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IEA--

    RTCA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RTCA
    Interactions:

        Search GeneGlobe Interaction Network for RTCA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RTCA (O004423 ENSP000002605634) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FBLP220873, ENSP000002218014I2D: score=2 STRING: ENSP00000221801
    RPL23AP627503, ENSP000003891034I2D: score=2 STRING: ENSP00000389103
    CDC5LQ994593, ENSP000003605324I2D: score=1 STRING: ENSP00000360532
    COPB2P356063, ENSP000003294194I2D: score=1 STRING: ENSP00000329419
    RPL21P467783, ENSP000003460274I2D: score=1 STRING: ENSP00000346027
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing IEA--

    RTCA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RTCA



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RTCA gene (2 alternative transcripts): 
    NM_001130841.1  NM_003729.3  

    Unigene Cluster for RTCA:

    RNA 3'-terminal phosphate cyclase
    Hs.484222  [show with all ESTs]
    Unigene Representative Sequence: NM_001130841
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370128(uc010ouh.1 uc001dtd.3 uc001dtc.3) ENST00000498617
    ENST00000483474 ENST00000260563 ENST00000370126
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat RTCA using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RTCA
    SwitchGear 3'UTR luciferase reporter plasmidRTCA 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RTCA
    Predesigned siRNA for gene silencing in human, mouse, rat RTCA
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    OriGene clones in human, mouse for RTCA (see all 11)
    OriGene ORF clones in mouse, rat for RTCA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for RTCA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RTCA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RTCA
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RTCA
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat RTCA
      QuantiTect SYBR Green Assays in human, mouse, rat RTCA
      QuantiFast Probe-based Assays in human, mouse, rat RTCA

    Additional mRNA sequence: 

    AK292366.1 AK299793.1 AK307445.1 BC012604.1 Y11651.1 

    16 DOTS entries:

    DT.114635  DT.100026340  DT.95270615  DT.453671  DT.100788769  DT.102830319  DT.95235323  DT.97804649 
    DT.87015655  DT.100788766  DT.100788767  DT.121335640  DT.121335641  DT.75188785  DT.95204866  DT.97846291 

    Selected AceView cDNA sequences (see all 193):

    CF265160 BQ014646 BQ012496 CF528443 BG177155 F01796 CR606775 AA487844 
    BM674295 CR595704 BM826352 CB113075 BF196802 AA635825 CD724107 CA454545 
    BU621790 BQ775339 CR620930 CR595281 BX103770 CA418432 AU130186 AA878646 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RTCA    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                      -     -                       -                                       
    SP2:                                -     -     -                       -                                       
    SP3:                                -     -                             -                                       
    SP4:                                -     -                                                                     
    SP5:                                -                                                                           


    ECgene alternative splicing isoforms for RTCA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RTCA expression in normal human tissues (normalized intensities)      RTCA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCATTAGCCA
    RTCA Expression
    About this image


    RTCA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    RTCA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RTCA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.484222

    UniProtKB/Swiss-Prot: RTCA_HUMAN, O00442
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RTCA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RTCA gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rtca1 , 5 RNA terminal phosphate cyclase domain 15
    RNA 3'-terminal phosphate cyclase1
    85.79(n)1
    90.71(a)1
      3 (50.35 cM)5
    663681  NM_025517.31  NP_079793.21 
     1164889635 
    chicken
    (Gallus gallus)
    Aves RTCA1 RNA 3'-terminal phosphate cyclase 78.9(n)
    83.56(a)
      424468  XM_422311.2  XP_422311.1 
    lizard
    (Anolis carolinensis)
    Reptilia RTCA6
    RNA 3'-terminal phosphate cyclase
    82(a)
    1 ↔ 1
    4(87721367-87728259)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.79442 Xenopus laevis transcribed sequence with moderate similarity more 73.67(n)    CA789383.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb1582 sbcb158 72.62(n)   321129  BC046087.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG40611 CG4061 46.5(n)
    39.49(a)
      31175  NM_130621.3  NP_569977.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RCL16
    Endonuclease that cleaves pre-rRNA at site A2 for ...
    21(a)
    1 → many
    XV(307938-309041) YOL010W


    ENSEMBL Gene Tree for RTCA (if available)
    TreeFam Gene Tree for RTCA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RTCA gene
    RCL12  

    RTCA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RTCA (see all 498)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1884102901,2
    --100729716(+) GATGTA/GCAAGT 2 -- us2k10--------
    rs1419573241,2
    C--100733845(+) CAAGAC/TAGCAG 4 T I mis11Minor allele frequency- T:0.00NA 4520
    rs1856604351,2
    C--100733891(+) GGGTTA/TAAGTC 2 -- int10--------
    rs1997359641,2
    --100733896(+) TAAGTC/TCAGGT 2 -- int10--------
    rs1900748711,2
    --100733935(+) TGTCTA/GTGAGC 2 -- int10--------
    rs729820921,2
    C--100734127(+) TTGTAG/TTTTTT 2 -- int11Minor allele frequency- T:0.50WA 2
    rs1415512421,2
    --100734171(+) GTCTCA/GAATTC 2 -- int10--------
    rs1509110771,2
    --100734366(+) GCTAAC/GAGGCT 2 -- int10--------
    rs1133256661,2
    C,F--100734483(+) CTCACG/ACCTGT 2 -- int14Minor allele frequency- A:0.05WA CSA EA 241
    rs1830072861,2
    --100734561(+) GCAACA/GTGGCA 2 -- int10--------

    HapMap Linkage Disequilibrium report for RTCA (100731714 - 100758325 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RTCA: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RTCA
    DNA2.0 Custom Variant and Variant Library Synthesis for RTCA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611286    OMIM disorders: --

    1 disease for RTCA:    About MalaCards
    malaria


    RTCA for disorders           About GeneDecksing


    Export disorders for RTCA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RTCA gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with RTCA)
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    1. The human RNA 3'-terminal phosphate cyclase is a member of a new family of proteins conserved in Eucarya, Bacteria and Archaea. (PubMed id 9184239)1, 2, 3 Genschik P.... Filipowicz W. (EMBO J. 1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. RNA 3'-terminal phosphate cyclase from HeLa cells. (PubMed id 2199762)1, 2 Filipowicz W. and Vincente O. (Methods Enzymol. 1990)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8634 HGNC: 17981 AceView: RTCD1 Ensembl:ENSG00000137996 euGenes: HUgn8634
    ECgene: RTCA H-InvDB: RTCA

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RTCA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RTCA gene:
    Search GeneIP for patents involving RTCA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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