Aliases for RTCA Gene
External Ids for RTCA Gene
Previous HGNC Symbols for RTCA Gene
Previous GeneCards Identifiers for RTCA Gene
This gene encodes a member of the RNA 3'-phosphate cyclase family. The encoded protein plays a role in RNA metabolism by catalyzing the ATP-dependent conversion of the 3'-phosphate of RNA substrates to a 2',3'-cyclic phosphodiester. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
GeneCards Summary for RTCA Gene
RTCA (RNA 3'-Terminal Phosphate Cyclase) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and RNA-3-phosphate cyclase activity. An important paralog of this gene is RCL1.
UniProtKB/Swiss-Prot for RTCA Gene
Catalyzes the conversion of 3-phosphate to a 2,3-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3P to produce RNA-N3PP5A; (C) and attack of the adjacent 2-hydroxyl on the 3-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.