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Aliases for RTCA Gene

Aliases for RTCA Gene

  • RNA 3'-Terminal Phosphate Cyclase 2
  • RTCD1 3 4 6
  • RPC 3 4 6
  • RNA Terminal Phosphate Cyclase Domain-Containing Protein 1 3 4
  • RNA Terminal Phosphate Cyclase Domain 1 2 3
  • RNA 3-Terminal Phosphate Cyclase 2 3
  • RTC Domain-Containing Protein 1 3 4
  • RTC1 3 4
  • RTC Domain Containing 1 2
  • RNA-3-Phosphate Cyclase 4
  • RNA Cyclase 4
  • EC 6.5.1.4 4
  • RPC1 4

External Ids for RTCA Gene

Previous HGNC Symbols for RTCA Gene

  • RTCD1

Previous GeneCards Identifiers for RTCA Gene

  • GC01P100732

Summaries for RTCA Gene

Entrez Gene Summary for RTCA Gene

  • This gene encodes a member of the RNA 3'-phosphate cyclase family. The encoded protein plays a role in RNA metabolism by catalyzing the ATP-dependent conversion of the 3'-phosphate of RNA substrates to a 2',3'-cyclic phosphodiester. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for RTCA Gene

RTCA (RNA 3'-Terminal Phosphate Cyclase) is a Protein Coding gene. GO annotations related to this gene include RNA binding and RNA-3-phosphate cyclase activity. An important paralog of this gene is RCL1.

UniProtKB/Swiss-Prot for RTCA Gene

  • Catalyzes the conversion of 3-phosphate to a 2,3-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3P to produce RNA-N3PP5A; (C) and attack of the adjacent 2-hydroxyl on the 3-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTCA Gene

Genomics for RTCA Gene

Genomic Location for RTCA Gene

Start:
100,266,158 bp from pter
End:
100,292,769 bp from pter
Size:
26,612 bases
Orientation:
Plus strand

Genomic View for RTCA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RTCA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTCA Gene

No data available for Regulatory Elements for RTCA Gene

Proteins for RTCA Gene

  • Protein details for RTCA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00442-RTCA_HUMAN
    Recommended name:
    RNA 3-terminal phosphate cyclase
    Protein Accession:
    O00442
    Secondary Accessions:
    • Q5VVL5
    • Q5VVL6
    • Q96E99

    Protein attributes for RTCA Gene

    Size:
    366 amino acids
    Molecular mass:
    39337 Da
    Quaternary structure:
    • Monomer

    Alternative splice isoforms for RTCA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RTCA Gene

Proteomics data for RTCA Gene at MOPED

Post-translational modifications for RTCA Gene

  • Ubiquitination at Lys163
  • Modification sites at PhosphoSitePlus

Other Protein References for RTCA Gene

No data available for DME Specific Peptides for RTCA Gene

Domains for RTCA Gene

Graphical View of Domain Structure for InterPro Entry

O00442

UniProtKB/Swiss-Prot:

RTCA_HUMAN :
  • O00442
Family:
  • Belongs to the RNA 3-terminal cyclase family. Type 1 subfamily.
genes like me logo Genes that share domains with RTCA: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for RTCA Gene

Function for RTCA Gene

Molecular function for RTCA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + RNA 3-terminal-phosphate = AMP + diphosphate + RNA terminal-2,3-cyclic-phosphate
UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of 3-phosphate to a 2,3-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3P to produce RNA-N3PP5A; (C) and attack of the adjacent 2-hydroxyl on the 3-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing

Enzyme Numbers (IUBMB) for RTCA Gene

Gene Ontology (GO) - Molecular Function for RTCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 9184239
GO:0003824 catalytic activity --
GO:0003963 RNA-3-phosphate cyclase activity IEA --
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RTCA: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RTCA

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RTCA Gene

Localization for RTCA Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTCA Gene

Nucleus, nucleoplasm.

Gene Ontology (GO) - Cellular Components for RTCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with RTCA: view

No data available for Subcellular locations from COMPARTMENTS for RTCA Gene

Pathways for RTCA Gene

SuperPathways for RTCA Gene

No Data Available

Gene Ontology (GO) - Biological Process for RTCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with RTCA: view

No data available for Pathways by source for RTCA Gene

Transcripts for RTCA Gene

Unigene Clusters for RTCA Gene

RNA 3-terminal phosphate cyclase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RTCA

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTCA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for RTCA Gene

GeneLoc Exon Structure for
RTCA
ECgene alternative splicing isoforms for
RTCA

Expression for RTCA Gene

mRNA expression in normal human tissues for RTCA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RTCA Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RTCA Gene

SOURCE GeneReport for Unigene cluster for RTCA Gene Hs.484222

mRNA Expression by UniProt/SwissProt for RTCA Gene

O00442-RTCA_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with RTCA: view

Expression partners for RTCA Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RTCA Gene

Orthologs for RTCA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RTCA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RTCA 35
  • 92.81 (n)
  • 95.63 (a)
RTCA 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RTCA 35
  • 92.62 (n)
  • 95.63 (a)
RTCA 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rtca 35
  • 85.79 (n)
  • 90.71 (a)
Rtca 16
Rtca 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RTCD1 35
  • 99.38 (n)
  • 98.94 (a)
RTCA 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rtcd1 35
  • 86.52 (n)
  • 90.98 (a)
oppossum
(Monodelphis domestica)
Mammalia RTCA 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RTCA 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves RTCA 35
  • 78.9 (n)
  • 83.56 (a)
RTCA 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RTCA 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rtca 35
  • 68.61 (n)
  • 75.28 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7944 35
zebrafish
(Danio rerio)
Actinopterygii rtca 35
  • 67.77 (n)
  • 74.93 (a)
sbcb158 35
rtca 36
  • 72 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10661 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004820 35
  • 52.27 (n)
  • 44.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4061 35
  • 46.5 (n)
  • 39.49 (a)
CG4061 36
  • 40 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RCL1 36
  • 21 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5419 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToOne
Species with no ortholog for RTCA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RTCA Gene

ENSEMBL:
Gene Tree for RTCA (if available)
TreeFam:
Gene Tree for RTCA (if available)

Paralogs for RTCA Gene

Paralogs for RTCA Gene

genes like me logo Genes that share paralogs with RTCA: view

Variants for RTCA Gene

Sequence variations from dbSNP and Humsavar for RTCA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3131832 -- 100,276,352(-) GTGAA(C/T)TGATT intron-variant
rs3131833 -- 100,275,138(-) GTTCC(C/T)ACATT intron-variant
rs3131834 -- 100,270,208(-) taaaa(C/T)CTTCT intron-variant
rs4268370 -- 100,278,549(+) AGGAT(C/T)ACTGA intron-variant
rs4325147 -- 100,283,633(+) GCATA(A/G)TTATT intron-variant

Relevant External Links for RTCA Gene

HapMap Linkage Disequilibrium report
RTCA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RTCA Gene

Disorders for RTCA Gene

No disorders were found for RTCA Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RTCA Gene

Publications for RTCA Gene

  1. The human RNA 3'-terminal phosphate cyclase is a member of a new family of proteins conserved in Eucarya, Bacteria and Archaea. (PMID: 9184239) Genschik P. … Filipowicz W. (EMBO J. 1997) 2 3 4
  2. RNA 3'-terminal phosphate cyclase from HeLa cells. (PMID: 2199762) Filipowicz W. … Vincente O. (Methods Enzymol. 1990) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3

Products for RTCA Gene

Sources for RTCA Gene

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