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Aliases for RTBDN Gene

Aliases for RTBDN Gene

  • Retbindin 2 3

External Ids for RTBDN Gene

Previous GeneCards Identifiers for RTBDN Gene

  • GC19M013067
  • GC19M013159
  • GC19M012781
  • GC19M012936
  • GC19M012507

Summaries for RTBDN Gene

Entrez Gene Summary for RTBDN Gene

  • This gene was first identified in a study of human eye tissues. The protein encoded by this gene is preferentially expressed in the retina and may play a role in binding retinoids and other carotenoids as it shares homology with riboflavin binding proteins. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for RTBDN Gene

RTBDN (Retbindin) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RTBDN Gene

Genomics for RTBDN Gene

Regulatory Elements for RTBDN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RTBDN Gene

12,825,477 bp from pter
12,835,428 bp from pter
9,952 bases
Minus strand

Genomic View for RTBDN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RTBDN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RTBDN Gene

Proteins for RTBDN Gene

  • Protein details for RTBDN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • F1T0I8
    • Q9BWT5

    Protein attributes for RTBDN Gene

    229 amino acids
    Molecular mass:
    24615 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RTBDN Gene


neXtProt entry for RTBDN Gene

Proteomics data for RTBDN Gene at MOPED

Post-translational modifications for RTBDN Gene

  • Glycosylation at Asn183
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RTBDN Gene

Domains for RTBDN Gene

Protein Domains for RTBDN Gene


Suggested Antigen Peptide Sequences for RTBDN Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9BSG5
  • Belongs to the folate receptor family.
genes like me logo Genes that share domains with RTBDN: view

No data available for Gene Families for RTBDN Gene

Function for RTBDN Gene

Phenotypes for RTBDN Gene

MGI mutant phenotypes for RTBDN:
inferred from 1 alleles
GenomeRNAi human phenotypes for RTBDN:
genes like me logo Genes that share phenotypes with RTBDN: view

Animal Model Products

miRNA for RTBDN Gene

miRTarBase miRNAs that target RTBDN

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RTBDN

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for RTBDN Gene

Localization for RTBDN Gene

Subcellular locations from UniProtKB/Swiss-Prot for RTBDN Gene


Subcellular locations from

Jensen Localization Image for RTBDN Gene COMPARTMENTS Subcellular localization image for RTBDN gene
Compartment Confidence
extracellular 3
cytosol 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RTBDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with RTBDN: view

Pathways for RTBDN Gene

SuperPathways for RTBDN Gene

No Data Available

Interacting Proteins for RTBDN Gene

Gene Ontology (GO) - Biological Process for RTBDN Gene


No data available for Pathways by source for RTBDN Gene

Transcripts for RTBDN Gene

Unigene Clusters for RTBDN Gene

Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RTBDN

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RTBDN Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - -
SP8: - - - - - - -
SP9: - - - - -
SP10: - -
SP11: - - - - - - -
SP12: - -

Relevant External Links for RTBDN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RTBDN Gene

mRNA expression in normal human tissues for RTBDN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RTBDN Gene

This gene is overexpressed in Pituitary (11.1), Brain - Amygdala (6.2), Brain - Frontal Cortex (BA9) (5.9), Brain - Cortex (5.9), Brain - Anterior cingulate cortex (BA24) (5.7), and Brain - Hippocampus (4.6).

Protein differential expression in normal tissues for RTBDN Gene

This gene is overexpressed in Vitreous humor (66.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RTBDN Gene

SOURCE GeneReport for Unigene cluster for RTBDN Gene Hs.21162

mRNA Expression by UniProt/SwissProt for RTBDN Gene

Tissue specificity: Expressed in retina
genes like me logo Genes that share expressions with RTBDN: view

Expression partners for RTBDN Gene

In Situ Assay Products

Orthologs for RTBDN Gene

This gene was present in the common ancestor of mammals.

Orthologs for RTBDN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RTBDN 35
  • 76.62 (n)
  • 65.88 (a)
  • 60 (a)
(Canis familiaris)
Mammalia RTBDN 35
  • 79.05 (n)
  • 70 (a)
  • 71 (a)
(Mus musculus)
Mammalia Rtbdn 35
  • 73.03 (n)
  • 60.67 (a)
Rtbdn 16
Rtbdn 36
  • 51 (a)
(Pan troglodytes)
Mammalia RTBDN 35
  • 99.36 (n)
  • 98.85 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Rtbdn 35
  • 73.77 (n)
  • 63.93 (a)
Species with no ortholog for RTBDN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RTBDN Gene

Gene Tree for RTBDN (if available)
Gene Tree for RTBDN (if available)

Paralogs for RTBDN Gene Pseudogenes for RTBDN Gene

genes like me logo Genes that share paralogs with RTBDN: view

No data available for Paralogs for RTBDN Gene

Variants for RTBDN Gene

Sequence variations from dbSNP and Humsavar for RTBDN Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs11104 -- 12,825,766(+) GAGGT(A/G)CGAGG reference, synonymous-codon, utr-variant-3-prime
rs13628 - 12,825,803(+) CCCGG(C/G)CCCGT missense, reference, utr-variant-3-prime
rs1466306 -- 12,828,978(-) ACCCT(A/G)GCTCA intron-variant, reference, missense
rs1993467 -- 12,830,738(-) GGTCA(G/T)CTGGA upstream-variant-2KB, intron-variant
rs3745648 -- 12,832,824(-) GGTAA(C/G)AGCGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RTBDN Gene

Variant ID Type Subtype PubMed ID
dgv3733n71 CNV Loss 21882294
nsv911082 CNV Loss 21882294
nsv2420 CNV Insertion 18451855
nsv911083 CNV Loss 21882294

Relevant External Links for RTBDN Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RTBDN Gene

Disorders for RTBDN Gene

Relevant External Links for RTBDN

Genetic Association Database (GAD)

No disorders were found for RTBDN Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RTBDN Gene

Publications for RTBDN Gene

  1. Expressed sequence tag analysis of human retina for the NEIBank project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. (PMID: 12107411) Wistow G. … Peterson K. (Mol. Vis. 2002) 2 3 4
  2. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PMID: 19862010) Ganesh S.K. … Lin J.P. (Nat. Genet. 2009) 3 48
  3. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M. … Kato S. (Invest. Ophthalmol. Vis. Sci. 2011) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for RTBDN Gene

Sources for RTBDN Gene

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